Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc40_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 23 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 1.421E-4 3.268E-3 1.220E-2 3.268E-3 3 365
2 GO:0010736 serum response element binding 6.430E-4 7.394E-3 2.761E-2 1.479E-2 1 2
3 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1.383E-3 9.239E-3 3.450E-2 3.181E-2 2 182
4 GO:0070878 primary miRNA binding 1.607E-3 9.239E-3 3.450E-2 3.696E-2 1 5
5 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 2.774E-3 1.121E-2 4.184E-2
6.381E-2
 2 259
6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding 3.211E-3 1.121E-2 4.184E-2
7.386E-2
 1 10
7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 4.173E-3 1.121E-2 4.184E-2
9.598E-2
 1 13
8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding 4.494E-3 1.121E-2 4.184E-2
1.034E-1
 1 14
9 GO:0044213 intronic transcription regulatory region DNA binding 4.494E-3 1.121E-2 4.184E-2
1.034E-1
 1 14
10 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 5.203E-3 1.121E-2 4.184E-2
1.197E-1
 2 357
11 GO:1990841 promoter-specific chromatin binding 5.454E-3 1.121E-2 4.184E-2
1.254E-1
 1 17
12 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 5.846E-3 1.121E-2 4.184E-2
1.345E-1
 2 379
13 GO:0000987 proximal promoter sequence-specific DNA binding 6.430E-3 1.138E-2 4.248E-2
1.479E-1
 2 398
14 GO:0017091 AU-rich element binding 7.373E-3 1.211E-2 4.523E-2
1.696E-1
 1 23
15 GO:0035035 histone acetyltransferase binding 9.608E-3 1.473E-2
5.502E-2
2.210E-1
 1 30
16 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2.104E-2 3.024E-2
1.129E-1
4.838E-1
 1 66
17 GO:0031490 chromatin DNA binding 2.702E-2 3.656E-2
1.365E-1
6.216E-1
 1 85
18 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 3.298E-2 3.988E-2
1.489E-1
7.586E-1
 1 104
19 GO:0042826 histone deacetylase binding 3.610E-2 3.988E-2
1.489E-1
8.304E-1
 1 114
20 GO:0001078 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific 3.610E-2 3.988E-2
1.489E-1
8.304E-1
 1 114
21 GO:0001046 core promoter sequence-specific DNA binding 3.642E-2 3.988E-2
1.489E-1
8.376E-1
 1 115
Show 16 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 398 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007616 long-term memory 4.272E-5 8.694E-3
5.707E-2
 1.700E-2 2 32
2 GO:0030217 T cell differentiation 4.369E-5 8.694E-3
5.707E-2
 1.739E-2 3 245
3 GO:0030098 lymphocyte differentiation 1.327E-4 1.761E-2
1.156E-1
5.283E-2
 3 356
4 GO:0033077 T cell differentiation in thymus 3.197E-4 1.873E-2
1.229E-1
1.272E-1
 2 87
5 GO:0071594 thymocyte aggregation 3.197E-4 1.873E-2
1.229E-1
1.272E-1
 2 87
6 GO:0072303 positive regulation of glomerular metanephric mesangial cell proliferation 3.222E-4 1.873E-2
1.229E-1
1.282E-1
 1 1
7 GO:0003343 septum transversum development 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
8 GO:0072301 regulation of metanephric glomerular mesangial cell proliferation 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
9 GO:0061145 lung smooth muscle development 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
10 GO:0071506 cellular response to mycophenolic acid 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
11 GO:0060532 bronchus cartilage development 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
12 GO:0003342 proepicardium development 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
13 GO:0071505 response to mycophenolic acid 6.443E-4 1.873E-2
1.229E-1
2.564E-1
 1 2
14 GO:0007613 memory 6.587E-4 1.873E-2
1.229E-1
2.622E-1
 2 125
15 GO:1900222 negative regulation of amyloid-beta clearance 9.663E-4 2.173E-2
1.427E-1
3.846E-1
 1 3
16 GO:0048167 regulation of synaptic plasticity 1.199E-3 2.173E-2
1.427E-1
4.772E-1
 2 169
17 GO:0046016 positive regulation of transcription by glucose 1.288E-3 2.173E-2
1.427E-1
5.127E-1
 1 4
18 GO:0010735 positive regulation of transcription via serum response element binding 1.288E-3 2.173E-2
1.427E-1
5.127E-1
 1 4
19 GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation 1.288E-3 2.173E-2
1.427E-1
5.127E-1
 1 4
20 GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development 1.288E-3 2.173E-2
1.427E-1
5.127E-1
 1 4
21 GO:0072300 positive regulation of metanephric glomerulus development 1.610E-3 2.173E-2
1.427E-1
6.408E-1
 1 5
22 GO:0071504 cellular response to heparin 1.610E-3 2.173E-2
1.427E-1
6.408E-1
 1 5
23 GO:0072223 metanephric glomerular mesangium development 1.610E-3 2.173E-2
1.427E-1
6.408E-1
 1 5
24 GO:0035912 dorsal aorta morphogenesis 1.610E-3 2.173E-2
1.427E-1
6.408E-1
 1 5
25 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development 1.610E-3 2.173E-2
1.427E-1
6.408E-1
 1 5
26 GO:0045991 carbon catabolite activation of transcription 1.610E-3 2.173E-2
1.427E-1
6.408E-1
 1 5
27 GO:0009749 response to glucose 1.740E-3 2.173E-2
1.427E-1
6.925E-1
 2 204
28 GO:0009746 response to hexose 1.825E-3 2.173E-2
1.427E-1
7.264E-1
 2 209
29 GO:0072298 regulation of metanephric glomerulus development 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
30 GO:0035907 dorsal aorta development 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
31 GO:0072126 positive regulation of glomerular mesangial cell proliferation 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
32 GO:1900221 regulation of amyloid-beta clearance 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
33 GO:0071503 response to heparin 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
34 GO:0046015 regulation of transcription by glucose 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
35 GO:0045990 carbon catabolite regulation of transcription 1.932E-3 2.173E-2
1.427E-1
7.689E-1
 1 6
36 GO:0034284 response to monosaccharide 1.966E-3 2.173E-2
1.427E-1
7.824E-1
 2 217
37 GO:0097242 amyloid-beta clearance 2.253E-3 2.300E-2
1.510E-1
8.969E-1
 1 7
38 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 2.253E-3 2.300E-2
1.510E-1
8.969E-1
 1 7
39 GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation 2.253E-3 2.300E-2
1.510E-1
8.969E-1
 1 7
40 GO:0009743 response to carbohydrate 2.437E-3 2.329E-2
1.529E-1
9.700E-1
 2 242
41 GO:0072239 metanephric glomerulus vasculature development 2.575E-3 2.329E-2
1.529E-1
1.000E0
 1 8
42 GO:0060710 chorio-allantoic fusion 2.575E-3 2.329E-2
1.529E-1
1.000E0
 1 8
43 GO:1901724 positive regulation of cell proliferation involved in kidney development 2.575E-3 2.329E-2
1.529E-1
1.000E0
 1 8
44 GO:0060534 trachea cartilage development 2.575E-3 2.329E-2
1.529E-1
1.000E0
 1 8
45 GO:0061448 connective tissue development 2.935E-3 2.561E-2
1.681E-1
1.000E0
 2 266
46 GO:0007611 learning or memory 3.045E-3 2.561E-2
1.681E-1
1.000E0
 2 271
47 GO:0050803 regulation of synapse structure or activity 3.067E-3 2.561E-2
1.681E-1
1.000E0
 2 272
48 GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 3.218E-3 2.561E-2
1.681E-1
1.000E0
 1 10
49 GO:0022028 tangential migration from the subventricular zone to the olfactory bulb 3.218E-3 2.561E-2
1.681E-1
1.000E0
 1 10
50 GO:0072124 regulation of glomerular mesangial cell proliferation 3.539E-3 2.561E-2
1.681E-1
1.000E0
 1 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 1 input genes in category / 52 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 362 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000295 trabecula carnea hypoplasia 1.901E-4 2.426E-2
1.569E-1
6.882E-2
 2 59
2 MP:0003720 abnormal neural tube closure 2.125E-4 2.426E-2
1.569E-1
7.694E-2
 3 394
3 MP:0010503 myocardial trabeculae hypoplasia 2.915E-4 2.426E-2
1.569E-1
1.055E-1
 2 73
4 MP:0010502 ventricle myocardium hypoplasia 3.861E-4 2.426E-2
1.569E-1
1.398E-1
 2 84
5 MP:0013599 Leydig cell atrophy 3.863E-4 2.426E-2
1.569E-1
1.398E-1
 1 1
6 MP:0004067 abnormal trabecula carnea morphology 4.334E-4 2.426E-2
1.569E-1
1.569E-1
 2 89
7 MP:0010500 myocardium hypoplasia 5.803E-4 2.426E-2
1.569E-1
2.101E-1
 2 103
8 MP:0002024 increased T cell derived lymphoma incidence 5.916E-4 2.426E-2
1.569E-1
2.142E-1
 2 104
9 MP:0010365 increased thymus tumor incidence 6.030E-4 2.426E-2
1.569E-1
2.183E-1
 2 105
10 MP:0010499 abnormal ventricle myocardium morphology 7.870E-4 2.721E-2
1.760E-1
2.849E-1
 2 120
11 MP:0002740 heart hypoplasia 8.267E-4 2.721E-2
1.760E-1
2.993E-1
 2 123
12 MP:0012432 decreased prostate gland tumor incidence 1.159E-3 3.495E-2
2.261E-1
4.194E-1
 1 3
13 MP:0002189 abnormal myocardial trabeculae morphology 1.395E-3 3.884E-2
2.513E-1
5.049E-1
 2 160
14 MP:0002976 vascular smooth muscle hypotrophy 1.544E-3 3.994E-2
2.584E-1
5.591E-1
 1 4
Show 9 more annotations

6: Domain [Display Chart] 6 input genes in category / 26 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR021839 DUF3432 InterPro 3.203E-4 2.776E-3 1.070E-2 8.327E-3 1 1
2 IPR033897 MADS SRF-like InterPro 3.203E-4 2.776E-3 1.070E-2 8.327E-3 1 1
3 PF11914 DUF3432 Pfam 3.203E-4 2.776E-3 1.070E-2 8.327E-3 1 1
4 PF04553 Tis11B N Pfam 6.404E-4 3.330E-3 1.284E-2 1.665E-2 1 2
5 IPR007635 Tis11B N InterPro 6.404E-4 3.330E-3 1.284E-2 1.665E-2 1 2
6 IPR021849 DUF3446 InterPro 9.605E-4 3.568E-3 1.375E-2 2.497E-2 1 3
7 PF11928 DUF3446 Pfam 9.605E-4 3.568E-3 1.375E-2 2.497E-2 1 3
8 PS50066 MADS BOX 2 PROSITE 1.920E-3 4.539E-3 1.749E-2 4.993E-2 1 6
9 PS00350 MADS BOX 1 PROSITE 1.920E-3 4.539E-3 1.749E-2 4.993E-2 1 6
10 PF00319 SRF-TF Pfam 1.920E-3 4.539E-3 1.749E-2 4.993E-2 1 6
11 SM00432 MADS SMART 1.920E-3 4.539E-3 1.749E-2 4.993E-2 1 6
12 IPR002100 TF MADSbox InterPro 2.240E-3 4.853E-3 1.871E-2
5.824E-2
 1 7
13 4.10.1000.10 - Gene3D 1.274E-2 2.216E-2
8.541E-2
3.313E-1
 1 40
14 SM00356 ZnF C3H1 SMART 1.528E-2 2.216E-2
8.541E-2
3.972E-1
 1 48
15 PF00642 zf-CCCH Pfam 1.559E-2 2.216E-2
8.541E-2
4.054E-1
 1 49
16 SM00431 SCAN SMART 1.780E-2 2.216E-2
8.541E-2
4.629E-1
 1 56
17 PF02023 SCAN Pfam 1.843E-2 2.216E-2
8.541E-2
4.793E-1
 1 58
18 PS50804 SCAN BOX PROSITE 1.843E-2 2.216E-2
8.541E-2
4.793E-1
 1 58
19 IPR003309 SCAN dom InterPro 1.843E-2 2.216E-2
8.541E-2
4.793E-1
 1 58
20 IPR000571 Znf CCCH InterPro 1.843E-2 2.216E-2
8.541E-2
4.793E-1
 1 58
21 PS50103 ZF C3H1 PROSITE 1.843E-2 2.216E-2
8.541E-2
4.793E-1
 1 58
22 IPR008916 Retrov capsid C InterPro 1.875E-2 2.216E-2
8.541E-2
4.875E-1
 1 59
Show 17 more annotations

7: Pathway [Display Chart] 4 input genes in category / 46 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138044 Trk receptor signaling mediated by the MAPK pathway BioSystems: Pathway Interaction Database 3.134E-5 1.442E-3 6.368E-3 1.442E-3 2 29
2 138057 ErbB1 downstream signaling BioSystems: Pathway Interaction Database 3.946E-4 9.075E-3 4.008E-2 1.815E-2 2 102
3 373901 HTLV-I infection BioSystems: KEGG 2.459E-3 2.367E-2
1.046E-1
1.131E-1
 2 256
4 PW:0000060 long term potentiation Pathway Ontology 2.889E-3 2.367E-2
1.046E-1
1.329E-1
 1 9
5 M89 Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway MSigDB C2 BIOCARTA (v6.0) 3.530E-3 2.367E-2
1.046E-1
1.624E-1
 1 11
6 1269727 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA BioSystems: REACTOME 5.771E-3 2.367E-2
1.046E-1
2.655E-1
 1 18
7 M10547 Role of MAL in Rho-Mediated Activation of SRF MSigDB C2 BIOCARTA (v6.0) 6.091E-3 2.367E-2
1.046E-1
2.802E-1
 1 19
8 138078 p38 signaling mediated by MAPKAP kinases BioSystems: Pathway Interaction Database 6.411E-3 2.367E-2
1.046E-1
2.949E-1
 1 20
9 M2623 IGF-1 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 6.731E-3 2.367E-2
1.046E-1
3.096E-1
 1 21
10 M5489 IL 6 signaling pathway MSigDB C2 BIOCARTA (v6.0) 7.050E-3 2.367E-2
1.046E-1
3.243E-1
 1 22
11 M765 Insulin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 7.050E-3 2.367E-2
1.046E-1
3.243E-1
 1 22
12 138049 PDGFR-alpha signaling pathway BioSystems: Pathway Interaction Database 7.050E-3 2.367E-2
1.046E-1
3.243E-1
 1 22
13 137969 Signaling events mediated by PRL BioSystems: Pathway Interaction Database 7.370E-3 2.367E-2
1.046E-1
3.390E-1
 1 23
14 M9043 Growth Hormone Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 8.967E-3 2.367E-2
1.046E-1
4.125E-1
 1 28
15 M1909 EGF Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.924E-3 2.367E-2
1.046E-1
4.565E-1
 1 31
16 M2529 PDGF Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.024E-2 2.367E-2
1.046E-1
4.712E-1
 1 32
17 137967 Trk receptor signaling mediated by PI3K and PLC-gamma BioSystems: Pathway Interaction Database 1.024E-2 2.367E-2
1.046E-1
4.712E-1
 1 32
18 138062 Signaling events mediated by HDAC Class II BioSystems: Pathway Interaction Database 1.088E-2 2.367E-2
1.046E-1
5.005E-1
 1 34
19 101144 Prion diseases BioSystems: KEGG 1.120E-2 2.367E-2
1.046E-1
5.152E-1
 1 35
20 P05911 Angiotensin II-stimulated signaling through G proteins and beta-arrestin PantherDB 1.120E-2 2.367E-2
1.046E-1
5.152E-1
 1 35
21 P05918 p38 MAPK pathway PantherDB 1.152E-2 2.367E-2
1.046E-1
5.298E-1
 1 36
22 M12012 p38 MAPK Pathway MSigDB C2 BIOCARTA (v6.0) 1.184E-2 2.367E-2
1.046E-1
5.445E-1
 1 37
23 M12645 G alpha 13 Pathway MSigDB C2 BIOCARTA (v6.0) 1.184E-2 2.367E-2
1.046E-1
5.445E-1
 1 37
24 169356 RhoA signaling pathway BioSystems: Pathway Interaction Database 1.311E-2 2.513E-2
1.110E-1
6.030E-1
 1 41
25 M2579 Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v6.0) 1.438E-2 2.624E-2
1.159E-1
6.615E-1
 1 45
26 137993 Calcineurin-regulated NFAT-dependent transcription in lymphocytes BioSystems: Pathway Interaction Database 1.533E-2 2.624E-2
1.159E-1
7.054E-1
 1 48
27 138027 Regulation of Androgen receptor activity BioSystems: Pathway Interaction Database 1.597E-2 2.624E-2
1.159E-1
7.346E-1
 1 50
28 138018 Downstream signaling in naive CD8+ T cells BioSystems: Pathway Interaction Database 1.597E-2 2.624E-2
1.159E-1
7.346E-1
 1 50
29 138085 Coregulation of Androgen receptor activity BioSystems: Pathway Interaction Database 1.819E-2 2.885E-2
1.274E-1
8.367E-1
 1 57
30 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 1.946E-2 2.983E-2
1.318E-1
8.950E-1
 1 61
31 P04393 Ras Pathway PantherDB 2.167E-2 3.161E-2
1.396E-1
9.969E-1
 1 68
32 1269312 Interferon alpha/beta signaling BioSystems: REACTOME 2.199E-2 3.161E-2
1.396E-1
1.000E0
 1 69
33 137930 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) BioSystems: Pathway Interaction Database 2.294E-2 3.197E-2
1.412E-1
1.000E0
 1 72
34 138014 Glucocorticoid receptor regulatory network BioSystems: Pathway Interaction Database 2.609E-2 3.530E-2
1.559E-1
1.000E0
 1 82
35 P00036 Interleukin signaling pathway PantherDB 2.924E-2 3.776E-2
1.668E-1
1.000E0
 1 92
36 1269725 Regulation of mRNA stability by proteins that bind AU-rich elements BioSystems: REACTOME 2.955E-2 3.776E-2
1.668E-1
1.000E0
 1 93
37 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 3.143E-2 3.908E-2
1.726E-1
1.000E0
 1 99
38 1269519 RHO GTPases Activate Formins BioSystems: REACTOME 3.707E-2 4.487E-2
1.982E-1
1.000E0
 1 117
39 P00047 PDGF signaling pathway PantherDB 4.019E-2 4.740E-2
2.094E-1
1.000E0
 1 127
Show 34 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1361 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15310743 Regulation of Egr-1, SRF, and Sp1 mRNA expression in contracting skeletal muscle cells. Pubmed 6.170E-8 4.198E-5 3.272E-4 8.397E-5 2 3
2 21479245 Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells. Pubmed 6.170E-8 4.198E-5 3.272E-4 8.397E-5 2 3
3 18780286 Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway. Pubmed 2.056E-7 9.328E-5 7.270E-4 2.799E-4 2 5
4 15749018 Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Pubmed 1.130E-6 3.077E-4 2.398E-3 1.539E-3 2 11
5 25020278 SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Pubmed 1.130E-6 3.077E-4 2.398E-3 1.539E-3 2 11
6 9799237 Serum response factor is essential for mesoderm formation during mouse embryogenesis. Pubmed 1.603E-6 3.181E-4 2.479E-3 2.182E-3 2 13
7 24623780 SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. Pubmed 1.870E-6 3.181E-4 2.479E-3 2.545E-3 2 14
8 15610731 The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Pubmed 1.870E-6 3.181E-4 2.479E-3 2.545E-3 2 14
9 9858769 Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Pubmed 3.143E-6 4.753E-4 3.704E-3 4.278E-3 2 18
10 27930960 Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Pubmed 1.084E-5 5.152E-4 4.015E-3 1.475E-2 2 33
11 21135125 Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
12 28072746 ZNF148 modulates TOP2A expression and cell proliferation via ceRNA regulatory mechanism in colorectal cancer. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
13 7845671 A biological role for Egr-1 in cell survival following ultra-violet irradiation. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
14 28206953 Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
15 12065847 Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
16 12818197 Constraints for zinc finger linker design as inferred from X-ray crystal structure of tandem Zif268-DNA complexes. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
17 23151675 Analysis of ZNF350/ZBRK1 promoter variants and breast cancer susceptibility in non-BRCA1/2 French Canadian breast cancer families. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
18 20204305 The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
19 12798262 How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning? Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
20 10710348 Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
21 16828713 Maternal aggression: new insights from Egr-1. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
22 24603130 Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
23 19112164 Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
24 3130602 A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
25 7929290 Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
26 20811575 Global Egr1-miRNAs binding analysis in PMA-induced K562 cells using ChIP-Seq. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
27 21533960 Early growth response gene 1 regulates bone properties in mice. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
28 25378406 Nucleosome-specific, time-dependent changes in histone modifications during activation of the early growth response 1 (Egr1) gene. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
29 11060034 Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
30 18171299 Microarray analysis of a Chlamydia pneumoniae-infected human epithelial cell line by use of gene ontology hierarchy. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
31 18054567 Inducible mouse model of chronic intestinal pseudo-obstruction by smooth muscle-specific inactivation of the SRF gene. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
32 8754857 Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1). Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
33 28716058 SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
34 18557893 Regulation of SRF/CArG-dependent gene transcription during chronic partial obstruction of murine small intestine. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
35 29643333 Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
36 22140445 Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
37 17629633 Alternative splicing and nonsense-mediated mRNA decay regulate gene expression of serum response factor. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
38 24787739 The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
39 17122890 Maintaining serum response factor activity in the older heart equal to that of the young adult is associated with better cardiac response to isoproterenol stress. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
40 18636116 Evaluation of EGR1 as a candidate gene for high myopia. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
41 20009530 Early growth response 1 (EGR1): a gene with as many names as biological functions. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
42 22597533 Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
43 15207639 Identification of a functional serum response element in the HTLV-I LTR. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
44 22593050 Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
45 17559061 Radiofrequency radiation (900 MHz) induces Egr-1 gene expression and affects cell-cycle control in human neuroblastoma cells. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
46 23632636 Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
47 26502071 Influence of quasi-specific sites on kinetics of target DNA search by a sequence-specific DNA-binding protein. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
48 16344600 Ethanol-induced liver injury: potential roles for egr-1. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
49 15699019 Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
50 19151320 Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Pubmed 1.571E-4 5.152E-4 4.015E-3
2.138E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 198 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ELK1 ELK1 interactions 9.843E-5 1.223E-2
7.175E-2
 1.949E-2 2 46
2 int:EGR1 EGR1 interactions 1.462E-4 1.223E-2
7.175E-2
 2.895E-2 2 56
3 int:MAPKAPK2 MAPKAPK2 interactions 1.853E-4 1.223E-2
7.175E-2
 3.668E-2 2 63
4 int:SRF SRF interactions 3.617E-4 1.740E-2
1.021E-1
7.162E-2
 2 88
5 int:CEBPB CEBPB interactions 4.394E-4 1.740E-2
1.021E-1
8.700E-2
 2 97
6 int:NFATC2 NFATC2 interactions 1.671E-3 3.726E-2
2.186E-1
3.308E-1
 2 190
7 int:NUTM2F NUTM2F interactions 1.694E-3 3.726E-2
2.186E-1
3.353E-1
 1 5
8 int:PRRX1 PRRX1 interactions 2.709E-3 3.726E-2
2.186E-1
5.363E-1
 1 8
9 int:NKX2-3 NKX2-3 interactions 2.709E-3 3.726E-2
2.186E-1
5.363E-1
 1 8
10 int:CIDEC CIDEC interactions 2.709E-3 3.726E-2
2.186E-1
5.363E-1
 1 8
11 int:HDAC3 HDAC3 interactions 2.758E-3 3.726E-2
2.186E-1
5.461E-1
 2 245
12 int:MIDN MIDN interactions 3.047E-3 3.726E-2
2.186E-1
6.033E-1
 1 9
13 int:TBX2 TBX2 interactions 3.047E-3 3.726E-2
2.186E-1
6.033E-1
 1 9
14 int:ZIC3 ZIC3 interactions 3.047E-3 3.726E-2
2.186E-1
6.033E-1
 1 9
15 int:SP1 SP1 interactions 3.147E-3 3.726E-2
2.186E-1
6.231E-1
 2 262
16 int:BARX2 BARX2 interactions 3.385E-3 3.726E-2
2.186E-1
6.702E-1
 1 10
17 int:ZNF350 ZNF350 interactions 3.385E-3 3.726E-2
2.186E-1
6.702E-1
 1 10
18 int:SMARCA4 SMARCA4 interactions 3.387E-3 3.726E-2
2.186E-1
6.707E-1
 2 272
19 int:HOPX HOPX interactions 4.061E-3 4.020E-2
2.359E-1
8.040E-1
 1 12
20 int:EDN1 EDN1 interactions 4.061E-3 4.020E-2
2.359E-1
8.040E-1
 1 12
21 int:ZNF316 ZNF316 interactions 5.074E-3 4.067E-2
2.387E-1
1.000E0
 1 15
22 int:NAB1 NAB1 interactions 5.411E-3 4.067E-2
2.387E-1
1.000E0
 1 16
23 int:MRTFB MRTFB interactions 5.411E-3 4.067E-2
2.387E-1
1.000E0
 1 16
24 int:SRFBP1 SRFBP1 interactions 5.749E-3 4.067E-2
2.387E-1
1.000E0
 1 17
25 int:RELA RELA interactions 5.987E-3 4.067E-2
2.387E-1
1.000E0
 2 364
26 int:ELOA2 ELOA2 interactions 6.086E-3 4.067E-2
2.387E-1
1.000E0
 1 18
27 int:CCDC130 CCDC130 interactions 6.086E-3 4.067E-2
2.387E-1
1.000E0
 1 18
28 int:ALDH3A1 ALDH3A1 interactions 6.423E-3 4.067E-2
2.387E-1
1.000E0
 1 19
29 int:ETV4 ETV4 interactions 6.423E-3 4.067E-2
2.387E-1
1.000E0
 1 19
30 int:ZFP36L1 ZFP36L1 interactions 6.423E-3 4.067E-2
2.387E-1
1.000E0
 1 19
31 int:MINPP1 MINPP1 interactions 6.760E-3 4.067E-2
2.387E-1
1.000E0
 1 20
32 int:ELK4 ELK4 interactions 6.760E-3 4.067E-2
2.387E-1
1.000E0
 1 20
33 int:CREBBP CREBBP interactions 7.123E-3 4.067E-2
2.387E-1
1.000E0
 2 398
34 int:CCN2 CCN2 interactions 7.771E-3 4.067E-2
2.387E-1
1.000E0
 1 23
35 int:ZNF165 ZNF165 interactions 7.771E-3 4.067E-2
2.387E-1
1.000E0
 1 23
36 int:CRIP2 CRIP2 interactions 8.444E-3 4.067E-2
2.387E-1
1.000E0
 1 25
37 int:FHL5 FHL5 interactions 8.444E-3 4.067E-2
2.387E-1
1.000E0
 1 25
38 int:FLI1 FLI1 interactions 8.444E-3 4.067E-2
2.387E-1
1.000E0
 1 25
39 int:TRIM10 TRIM10 interactions 8.781E-3 4.067E-2
2.387E-1
1.000E0
 1 26
40 int:CD63 CD63 interactions 9.117E-3 4.067E-2
2.387E-1
1.000E0
 1 27
41 int:IL1B IL1B interactions 9.117E-3 4.067E-2
2.387E-1
1.000E0
 1 27
42 int:TEAD1 TEAD1 interactions 9.454E-3 4.067E-2
2.387E-1
1.000E0
 1 28
43 int:MRTFA MRTFA interactions 9.454E-3 4.067E-2
2.387E-1
1.000E0
 1 28
44 int:FAM124A FAM124A interactions 9.790E-3 4.067E-2
2.387E-1
1.000E0
 1 29
45 int:ZKSCAN8 ZKSCAN8 interactions 9.790E-3 4.067E-2
2.387E-1
1.000E0
 1 29
46 int:GADD45B GADD45B interactions 1.046E-2 4.067E-2
2.387E-1
1.000E0
 1 31
47 int:ZNF148 ZNF148 interactions 1.046E-2 4.067E-2
2.387E-1
1.000E0
 1 31
48 int:MYOCD MYOCD interactions 1.046E-2 4.067E-2
2.387E-1
1.000E0
 1 31
49 int:SCAND1 SCAND1 interactions 1.046E-2 4.067E-2
2.387E-1
1.000E0
 1 31
50 int:MAGEB2 MAGEB2 interactions 1.046E-2 4.067E-2
2.387E-1
1.000E0
 1 31
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q22-q24 14q22-q24 3.462E-4 2.077E-3 5.089E-3 2.077E-3 1 2
2 3q21 3q21 4.148E-3 1.244E-2 3.049E-2 2.489E-2 1 24
3 5q31.1 5q31.1 1.120E-2 1.693E-2 4.149E-2
6.720E-2
 1 65
4 19q13.41 19q13.41 1.377E-2 1.693E-2 4.149E-2
8.262E-2
 1 80
5 6p21.1 6p21.1 1.411E-2 1.693E-2 4.149E-2
8.467E-2
 1 82
6 6p21.3 6p21.3 4.367E-2 4.367E-2
1.070E-1
2.620E-1
 1 257
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 102 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CCAWWNAAGG V$SRF Q4 CCAWWNAAGG V$SRF Q4 3.363E-4 2.800E-2
1.458E-1
 3.430E-2 2 74
2 V$EGR2 01 V$EGR2 01 1.526E-3 2.800E-2
1.458E-1
1.557E-1
 2 158
3 V$SRF C V$SRF C 1.998E-3 2.800E-2
1.458E-1
2.038E-1
 2 181
4 V$SRF Q4 V$SRF Q4 2.246E-3 2.800E-2
1.458E-1
2.291E-1
 2 192
5 V$HNF1 C V$HNF1 C 2.246E-3 2.800E-2
1.458E-1
2.291E-1
 2 192
6 V$SRF Q5 01 V$SRF Q5 01 2.293E-3 2.800E-2
1.458E-1
2.338E-1
 2 194
7 V$HNF1 01 V$HNF1 01 2.340E-3 2.800E-2
1.458E-1
2.386E-1
 2 196
8 V$SRF Q6 V$SRF Q6 2.707E-3 2.800E-2
1.458E-1
2.761E-1
 2 211
9 V$TFIIA Q6 V$TFIIA Q6 2.758E-3 2.800E-2
1.458E-1
2.813E-1
 2 213
10 V$MYCMAX B V$MYCMAX B 2.887E-3 2.800E-2
1.458E-1
2.945E-1
 2 218
11 V$EGR Q6 V$EGR Q6 3.019E-3 2.800E-2
1.458E-1
3.079E-1
 2 223
12 GTGGGTGK UNKNOWN GTGGGTGK UNKNOWN 3.320E-3 2.822E-2
1.469E-1
3.386E-1
 2 234
13 V$AHRARNT 02 V$AHRARNT 02 5.720E-3 4.488E-2
2.337E-1
5.835E-1
 1 14
Show 8 more annotations

12: Gene Family [Display Chart] 6 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1086 Myocyte enhancer factor 2 proteins|MADS box family genenames.org 1.648E-3 3.296E-3 4.944E-3 3.296E-3 1 5

13: Coexpression [Display Chart] 6 input genes in category / 949 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17211 Transcription factors down-regulated in LNCaP cells (prostate cancer) by expression of GR [GeneID=2908] off a lentiviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.520E-6 1.451E-3 1.078E-2 2.391E-3 2 10
2 M2696 Genes up-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of RELA [Gene ID=5970] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 5.161E-6 1.451E-3 1.078E-2 4.898E-3 3 149
3 M7892 Genes up-regulated in macrophages (12h): IFNG, TNF [GeneID=3458;7124] and rosiglitazone [PubChem=77999] versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.451E-3 1.078E-2 1.185E-2 3 200
4 M9830 Genes down-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.451E-3 1.078E-2 1.185E-2 3 200
5 M4524 Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.451E-3 1.078E-2 1.185E-2 3 200
6 M7881 Genes down-regulated in B cells: dark zone versus naïve. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.451E-3 1.078E-2 1.185E-2 3 200
7 M7885 Genes up-regulated in B cells: light zone versus naïve. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.451E-3 1.078E-2 1.185E-2 3 200
8 M4182 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.451E-3 1.078E-2 1.185E-2 3 200
9 19147588-Table2 Human Prostate Scharer09 23genes GeneSigDB 1.414E-5 1.451E-3 1.078E-2 1.342E-2 2 23
10 M9128 Genes up-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.529E-5 1.451E-3 1.078E-2 1.451E-2 3 214
11 12623842-Table1 Human BoneMarrow Magrangeas03 60genes GeneSigDB 6.288E-5 5.425E-3 4.033E-2
5.968E-2
 2 48
12 14749762-Table2 Human Leukemia Staber04 58genes GeneSigDB 7.678E-5 6.072E-3 4.513E-2
7.286E-2
 2 53
13 M14829 Genes down-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [GeneID=3205;4211]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.626E-4 1.131E-2
8.406E-2
1.543E-1
 2 77
14 M17082 Genes up-regulated in hematopoietic progenitor cells (HPC) of T lymphocyte and NK (natural killer) lineage. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.668E-4 1.131E-2
8.406E-2
1.583E-1
 2 78
15 M15565 Up-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 2.373E-4 1.501E-2
1.116E-1
2.252E-1
 2 93
16 18689800-TableS6 Human EmbryonicStemCell Thomas08 113genes GeneSigDB 3.379E-4 1.696E-2
1.261E-1
3.206E-1
 2 111
17 M19630 Up-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 3.947E-4 1.696E-2
1.261E-1
3.746E-1
 2 120
18 M16336 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.914E-4 1.696E-2
1.261E-1
5.613E-1
 2 147
19 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.364E-4 1.696E-2
1.261E-1
7.937E-1
 2 175
20 M2763 Genes down-regulated during early stages of differentiation of embryoid bodies from J1 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 8.651E-4 1.696E-2
1.261E-1
8.210E-1
 2 178
21 M377 Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v6.0) 9.239E-4 1.696E-2
1.261E-1
8.768E-1
 2 184
22 M384 Genes down-regulated in dendritic cell NIK NFkB2-KO versus dendritic cell NIK NFkB2-KO LPS and anti-CD40 stimulated. MSigDB C7: Immunologic Signatures (v6.0) 9.642E-4 1.696E-2
1.261E-1
9.150E-1
 2 188
23 M6495 Genes up-regulated in monocyte-derived dendritic cells: control versus treated with LGALS1 [GeneID=3956]. MSigDB C7: Immunologic Signatures (v6.0) 1.026E-3 1.696E-2
1.261E-1
9.739E-1
 2 194
24 M11350 Genes with GO annotation and down-regulated after DNA damage in cell lines from young donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.037E-3 1.696E-2
1.261E-1
9.838E-1
 2 195
25 M4958 Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (pDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.047E-3 1.696E-2
1.261E-1
9.939E-1
 2 196
26 M4940 Genes up-regulated in comparison of B cells versus plasmacytoid dendritic cells (pDC) . MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 1.696E-2
1.261E-1
1.000E0
 2 197
27 M6493 Genes up-regulated in monocyte-derived dendritic cells: LPS (3h) versus LPS and LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 1.696E-2
1.261E-1
1.000E0
 2 198
28 M5490 Up-regulated by induction of exogenous BRCA1 in EcR-293 cells MSigDB C2: CGP Curated Gene Sets (v6.0) 1.069E-3 1.696E-2
1.261E-1
1.000E0
 2 198
29 M9616 Genes down-regulated in CD42 high [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.261E-1
1.000E0
 2 199
30 M4055 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.261E-1
1.000E0
 2 199
31 M4157 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.261E-1
1.000E0
 2 199
32 M3028 Genes down-regulated in comparison of naive versus memory CD8 T cells (day 40+ following LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.261E-1
1.000E0
 2 199
33 M7264 Genes up-regulated in bone marrow-derived macrophages: control versus Listeria infected. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.261E-1
1.000E0
 2 199
34 M8421 Genes up-regulated in brain microglia versus spleen CD8- dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.261E-1
1.000E0
 2 199
35 M9621 Genes down-regulated in T reg: wildtype versus DNMT1 [GeneID=1786] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
36 M9895 Genes up-regulated in dendritic cells: untreated versus 24h after infection of Leishmania major. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
37 M4768 Genes down-regulated in comparison of lineage negative versus B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
38 M4567 Genes down-regulated in adult DN2 thymocytes versus adult DN3 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
39 M7271 Genes down-regulated in double positive thymocytes: TCF12 [GeneID=6939] knockout versus TCF3 and TCF12 [GeneID=6929;6938] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
40 M4139 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
41 M3491 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 20 min. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
42 M9610 Genes up-regulated in T reg: peripheral lymph nodes versus thymic CD24 high [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
43 M4971 Genes down-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 7 post-vaccination versus myeloid DCs at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
44 M3470 Genes up-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
45 M8769 Genes up-regulated in dendritic cells in response to LPS: wildtype versus NLRP10 [GeneID=338322] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
46 M7269 Genes down-regulated in double positive thymocytes: wildtype versus TCF3 and TCF12 [GeneID=6929;6938] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
47 M9545 Genes down-regulated dendritic cells: Ly6G+ versus Ly6G-. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
48 M5690 Genes up-regulated in comparsion of ActTreg versus ActCD4 (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
49 M5592 Genes down-regulated in comparison of central memory CD4 [GeneID=920] T cells versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
50 M4963 Genes up-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.261E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 1008 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6/3 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6/3 TCGA-Kidney 1.176E-5 1.185E-2
8.880E-2
 1.185E-2 3 185
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium/Ureter Normal RCC Ureter epithelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium/Ureter Normal RCC Ureter epithelium Adult, Development, and Cancer types 6.482E-5 1.373E-2
1.029E-1
6.533E-2
 2 46
3 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s2 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s2 Top 200 Genes StanfordMouse+HumanSingleCells 6.984E-5 1.373E-2
1.029E-1
7.040E-2
 3 336
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter T U/Ureter Normal Wilms T U/Ureter Normal Wilms T21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter T U/Ureter Normal Wilms T U/Ureter Normal Wilms T21 Adult, Development, and Cancer types 7.668E-5 1.373E-2
1.029E-1
7.729E-2
 2 50
5 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.121E-4 1.373E-2
1.029E-1
2.138E-1
 2 83
6 PCBC ratio EB from-OSK-L-l-p53KD vs EB from-ESC cfr-2X-p05 Embryoid Body Cells-reprogram OSK-L-l-p53KD vs Embryoid Body Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.173E-4 1.373E-2
1.029E-1
2.190E-1
 2 84
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK21 Adult, Development, and Cancer types 2.385E-4 1.373E-2
1.029E-1
2.404E-1
 2 88
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R14 Adult, Development, and Cancer types 2.385E-4 1.373E-2
1.029E-1
2.404E-1
 2 88
9 6mo cortical organoids wt 6mo cortical organoids wt pan subtypes intermediate neurons Overall Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt pan subtypes intermediate neurons Overall Top 100 Genes 2.958E-4 1.373E-2
1.029E-1
2.981E-1
 2 98
10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A Adult, Development, and Cancer types 3.725E-4 1.373E-2
1.029E-1
3.755E-1
 2 110
11 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k3 500 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.213E-4 1.373E-2
1.029E-1
4.247E-1
 2 117
12 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s10 intermediate neurons Subtype intermediate neurons s10 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s10 intermediate neurons Subtype intermediate neurons s10 Top 100 Genes 5.521E-4 1.373E-2
1.029E-1
5.565E-1
 2 134
13 Sample Type by Project: Shred 1/TCGA-Endometrium/Endometrial Adenocarcinoma/Mixed Serous and Endometrioid/1/4 Sample Type by Project: Shred 1/TCGA-Endometrium/Endometrial Adenocarcinoma/Mixed Serous and Endometrioid/1/4 TCGA-Endometrium 6.548E-4 1.373E-2
1.029E-1
6.600E-1
 2 146
14 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup4/Nptxr/Nptxr,Fos BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup4/Nptxr/Nptxr,Fos BrainMap 6.638E-4 1.373E-2
1.029E-1
6.691E-1
 2 147
15 gudmap dev gonad e11.5 F GonMes Sma k3 500 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.818E-4 1.373E-2
1.029E-1
6.873E-1
 2 149
16 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s9 intermediate neurons Subtype intermediate neurons s9 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s9 intermediate neurons Subtype intermediate neurons s9 Top 100 Genes 7.187E-4 1.373E-2
1.029E-1
7.245E-1
 2 153
17 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s1 intermediate neurons Subtype intermediate neurons s1 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s1 intermediate neurons Subtype intermediate neurons s1 Top 100 Genes 7.565E-4 1.373E-2
1.029E-1
7.626E-1
 2 157
18 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s11 intermediate neurons Subtype intermediate neurons s11 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s11 intermediate neurons Subtype intermediate neurons s11 Top 100 Genes 7.565E-4 1.373E-2
1.029E-1
7.626E-1
 2 157
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R21 Adult, Development, and Cancer types 7.661E-4 1.373E-2
1.029E-1
7.723E-1
 2 158
20 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s12 intermediate neurons Subtype intermediate neurons s12 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s12 intermediate neurons Subtype intermediate neurons s12 Top 100 Genes 7.953E-4 1.373E-2
1.029E-1
8.017E-1
 2 161
21 Kidney10XCellRanger Six2KI P0 unknown unknown Overall Top 200 Genes Kidney10XCellRanger Six2KI P0 unknown unknown Overall Top 200 Genes 8.451E-4 1.373E-2
1.029E-1
8.519E-1
 2 166
22 Kidney10XCellRanger Six2KI P0 unknown unknown Top 200 Kidney10XCellRanger Six2KI P0 unknown unknown Top 200 8.451E-4 1.373E-2
1.029E-1
8.519E-1
 2 166
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Adult, Development, and Cancer types 8.451E-4 1.373E-2
1.029E-1
8.519E-1
 2 166
24 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.0.4 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.0.4 Top 100 Genes 8.451E-4 1.373E-2
1.029E-1
8.519E-1
 2 166
25 BrainMap BrainAtlas - Human / Mouse Linnarsson Enteric glia Enteric glia Top 200 BrainMap BrainAtlas - Human / Mouse Linnarsson Enteric glia Enteric glia Top 200 BrainMap 8.553E-4 1.373E-2
1.029E-1
8.621E-1
 2 167
26 BrainMap BrainAtlas - Human / Mouse Linnarsson Enteric glia Enteric glia Overall Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Enteric glia Enteric glia Overall Top 200 Genes BrainMap 8.553E-4 1.373E-2
1.029E-1
8.621E-1
 2 167
27 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s2 intermediate neurons Subtype intermediate neurons s2 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s2 intermediate neurons Subtype intermediate neurons s2 Top 100 Genes 8.655E-4 1.373E-2
1.029E-1
8.724E-1
 2 168
28 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/A/subGroup3//Myoc/Astrocyte.Gja1.Myoc/PosteriorCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/A/subGroup3//Myoc/Astrocyte.Gja1.Myoc/PosteriorCortex BrainMap 8.757E-4 1.373E-2
1.029E-1
8.827E-1
 2 169
29 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s5 intermediate neurons Subtype intermediate neurons s5 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s5 intermediate neurons Subtype intermediate neurons s5 Top 100 Genes 8.860E-4 1.373E-2
1.029E-1
8.931E-1
 2 170
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Medulla post-natal kidney Renal cell carcinoma/Kidney Normal-Medulla post-natal kidney T12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Medulla post-natal kidney Renal cell carcinoma/Kidney Normal-Medulla post-natal kidney T12 Adult, Development, and Cancer types 8.964E-4 1.373E-2
1.029E-1
9.036E-1
 2 171
31 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 4 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 4 Top 200 Genes StanfordMouse+HumanSingleCells 9.173E-4 1.373E-2
1.029E-1
9.247E-1
 2 173
32 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 5 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 5 Top 200 Genes StanfordMouse+HumanSingleCells 9.385E-4 1.373E-2
1.029E-1
9.460E-1
 2 175
33 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s3 intermediate neurons Subtype intermediate neurons s3 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s3 intermediate neurons Subtype intermediate neurons s3 Top 100 Genes 9.385E-4 1.373E-2
1.029E-1
9.460E-1
 2 175
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter CD8 T cell/Ureter Normal RCC CD8 T cell/Ureter Normal RCC IN10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter CD8 T cell/Ureter Normal RCC CD8 T cell/Ureter Normal RCC IN10 Adult, Development, and Cancer types 9.815E-4 1.373E-2
1.029E-1
9.894E-1
 2 179
35 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R15 Adult, Development, and Cancer types 9.815E-4 1.373E-2
1.029E-1
9.894E-1
 2 179
36 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Mast cell/Ureter Normal RCC Mast cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Mast cell/Ureter Normal RCC Mast cell Adult, Development, and Cancer types 9.924E-4 1.373E-2
1.029E-1
1.000E0
 2 180
37 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg10 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg10 BrainMap 9.924E-4 1.373E-2
1.029E-1
1.000E0
 2 180
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Mast cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Mast cell Adult, Development, and Cancer types 9.924E-4 1.373E-2
1.029E-1
1.000E0
 2 180
39 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium/Ureter Normal RCC Ureter epithelium/Ureter Normal RCC N15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium/Ureter Normal RCC Ureter epithelium/Ureter Normal RCC N15 Adult, Development, and Cancer types 1.003E-3 1.373E-2
1.029E-1
1.000E0
 2 181
40 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Papillary renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Papillary renal cell carcinoma Adult, Development, and Cancer types 1.003E-3 1.373E-2
1.029E-1
1.000E0
 2 181
41 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 6 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 6 Top 200 Genes StanfordMouse+HumanSingleCells 1.003E-3 1.373E-2
1.029E-1
1.000E0
 2 181
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT14 Adult, Development, and Cancer types 1.014E-3 1.373E-2
1.029E-1
1.000E0
 2 182
43 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s7 intermediate neurons Subtype intermediate neurons s7 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s7 intermediate neurons Subtype intermediate neurons s7 Top 100 Genes 1.014E-3 1.373E-2
1.029E-1
1.000E0
 2 182
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F10 Adult, Development, and Cancer types 1.014E-3 1.373E-2
1.029E-1
1.000E0
 2 182
45 BrainMap BrainAtlas - Human / Mouse Linnarsson Ependymal Ependymal Overall Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Ependymal Ependymal Overall Top 200 Genes BrainMap 1.014E-3 1.373E-2
1.029E-1
1.000E0
 2 182
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-U Adult, Development, and Cancer types 1.014E-3 1.373E-2
1.029E-1
1.000E0
 2 182
47 BrainMap BrainAtlas - Human / Mouse Linnarsson Ependymal Ependymal Top 200 BrainMap BrainAtlas - Human / Mouse Linnarsson Ependymal Ependymal Top 200 BrainMap 1.014E-3 1.373E-2
1.029E-1
1.000E0
 2 182
48 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s14 intermediate neurons Subtype intermediate neurons s14 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s14 intermediate neurons Subtype intermediate neurons s14 Top 100 Genes 1.026E-3 1.373E-2
1.029E-1
1.000E0
 2 183
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R10 Adult, Development, and Cancer types 1.026E-3 1.373E-2
1.029E-1
1.000E0
 2 183
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK10 Adult, Development, and Cancer types 1.026E-3 1.373E-2
1.029E-1
1.000E0
 2 183
Show 45 more annotations

15: Computational [Display Chart] 4 input genes in category / 15 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 483 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 2.389E-8 1.154E-5 7.797E-5 1.154E-5 4 459
2 TGTGTGA,MIR-377:MSigDB TGTGTGA,MIR-377:MSigDB MSigDB 3.233E-7 6.690E-5 4.521E-4 1.561E-4 3 184
3 hsa-miR-150:PITA hsa-miR-150:PITA TOP PITA 4.155E-7 6.690E-5 4.521E-4 2.007E-4 3 200
4 hsa-miR-885-5p:Functional MTI Functional MTI miRTarbase 1.156E-5 1.396E-3 9.436E-3 5.585E-3 2 64
5 hsa-miR-191:PITA hsa-miR-191:PITA TOP PITA 1.677E-5 1.620E-3 1.095E-2 8.102E-3 2 77
6 hsa-miR-3074-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.127E-5 2.443E-3 1.651E-2 1.510E-2 2 105
7 hsa-miR-548an:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.364E-5 2.443E-3 1.651E-2 2.108E-2 2 124
8 hsa-miR-486-5p:PITA hsa-miR-486-5p:PITA TOP PITA 4.724E-5 2.443E-3 1.651E-2 2.282E-2 2 129
9 hsa-miR-3185:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.825E-5 2.443E-3 1.651E-2 3.780E-2 2 166
10 hsa-miR-365:PITA hsa-miR-365:PITA TOP PITA 8.015E-5 2.443E-3 1.651E-2 3.871E-2 2 168
11 hsa-miR-496:PITA hsa-miR-496:PITA TOP PITA 8.207E-5 2.443E-3 1.651E-2 3.964E-2 2 170
12 hsa-miR-146b-5p:PITA hsa-miR-146b-5p:PITA TOP PITA 8.304E-5 2.443E-3 1.651E-2 4.011E-2 2 171
13 hsa-miR-146a:PITA hsa-miR-146a:PITA TOP PITA 8.304E-5 2.443E-3 1.651E-2 4.011E-2 2 171
14 hsa-miR-1207-5p:PITA hsa-miR-1207-5p:PITA TOP PITA 8.304E-5 2.443E-3 1.651E-2 4.011E-2 2 171
15 hsa-miR-1178:PITA hsa-miR-1178:PITA TOP PITA 8.401E-5 2.443E-3 1.651E-2 4.058E-2 2 172
16 hsa-miR-5692c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.597E-5 2.443E-3 1.651E-2 4.153E-2 2 174
17 hsa-miR-5692b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.597E-5 2.443E-3 1.651E-2 4.153E-2 2 174
18 hsa-miR-575:PITA hsa-miR-575:PITA TOP PITA 1.004E-4 2.693E-3 1.820E-2 4.847E-2 2 188
19 hsa-miR-630:PITA hsa-miR-630:PITA TOP PITA 1.124E-4 2.854E-3 1.929E-2
5.430E-2
 2 199
20 hsa-miR-760:PITA hsa-miR-760:PITA TOP PITA 1.252E-4 2.854E-3 1.929E-2
6.047E-2
 2 210
21 hsa-miR-767-3p:PITA hsa-miR-767-3p:PITA TOP PITA 1.300E-4 2.854E-3 1.929E-2
6.279E-2
 2 214
22 hsa-miR-1237:PITA hsa-miR-1237:PITA TOP PITA 1.300E-4 2.854E-3 1.929E-2
6.279E-2
 2 214
23 hsa-miR-143:PITA hsa-miR-143:PITA TOP PITA 1.374E-4 2.885E-3 1.950E-2
6.635E-2
 2 220
24 hsa-miR-216a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.689E-4 3.263E-3 2.205E-2
8.158E-2
 2 244
25 hsa-miR-3681-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.689E-4 3.263E-3 2.205E-2
8.158E-2
 2 244
26 hsa-miR-891b:PITA hsa-miR-891b:PITA TOP PITA 2.037E-4 3.783E-3 2.557E-2
9.837E-2
 2 268
27 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 2.160E-4 3.837E-3 2.593E-2
1.043E-1
 2 276
28 hsa-miR-4756-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.318E-4 3.837E-3 2.593E-2
1.120E-1
 2 286
29 hsa-miR-1321:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.335E-4 3.837E-3 2.593E-2
1.128E-1
 2 287
30 hsa-miR-4739:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.383E-4 3.837E-3 2.593E-2
1.151E-1
 2 290
31 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 2.757E-4 4.296E-3 2.903E-2
1.332E-1
 2 312
32 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 3.234E-4 4.733E-3 3.199E-2
1.562E-1
 2 338
33 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 3.234E-4 4.733E-3 3.199E-2
1.562E-1
 2 338
34 hsa-miR-183-5p:Functional MTI Functional MTI miRTarbase 3.486E-4 4.920E-3 3.325E-2
1.684E-1
 2 351
35 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 3.565E-4 4.920E-3 3.325E-2
1.722E-1
 2 355
36 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 3.892E-4 4.974E-3 3.361E-2
1.880E-1
 2 371
37 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 3.892E-4 4.974E-3 3.361E-2
1.880E-1
 2 371
38 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 3.913E-4 4.974E-3 3.361E-2
1.890E-1
 2 372
39 hsa-miR-4286:mirSVR highEffct hsa-miR-4286:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.342E-4 5.270E-3 3.562E-2
2.097E-1
 2 392
40 hsa-miR-101-3p:Functional MTI Functional MTI miRTarbase 4.364E-4 5.270E-3 3.562E-2
2.108E-1
 2 393
41 hsa-miR-27b-3p:Functional MTI Functional MTI miRTarbase 5.004E-4 5.835E-3 3.944E-2
2.417E-1
 2 421
42 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 5.147E-4 5.835E-3 3.944E-2
2.486E-1
 2 427
43 hsa-miR-27a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.195E-4 5.835E-3 3.944E-2
2.509E-1
 2 429
44 hsa-miR-1915:mirSVR highEffct hsa-miR-1915:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.587E-4 6.133E-3 4.145E-2
2.698E-1
 2 445
45 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 5.915E-4 6.349E-3 4.291E-2
2.857E-1
 2 458
46 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 6.574E-4 6.902E-3 4.665E-2
3.175E-1
 2 483
47 TTCCGTT,MIR-191:MSigDB TTCCGTT,MIR-191:MSigDB MSigDB 2.240E-3 2.302E-2
1.556E-1
1.000E0
 1 27
48 hsa-miR-525-3p:PITA hsa-miR-525-3p:PITA TOP PITA 2.489E-3 2.454E-2
1.658E-1
1.000E0
 1 30
49 hsa-miR-524-3p:PITA hsa-miR-524-3p:PITA TOP PITA 2.489E-3 2.454E-2
1.658E-1
1.000E0
 1 30
50 hsa-miR-574-3p:PITA hsa-miR-574-3p:PITA TOP PITA 2.655E-3 2.565E-2
1.733E-1
1.000E0
 1 32
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 3529 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6051 UP Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.284E-10 4.532E-7 3.964E-6 4.532E-7 5 170
2 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.950E-8 5.205E-5 4.552E-4 1.041E-4 4 154
3 2211 UP Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.039E-6 1.777E-3 1.554E-2 2.131E-2 3 155
4 2210 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.643E-6 1.777E-3 1.554E-2 2.344E-2 3 160
5 1655 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.896E-6 1.777E-3 1.554E-2 2.434E-2 3 162
6 5324 UP Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.420E-6 1.777E-3 1.554E-2 2.618E-2 3 166
7 6680 UP Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.555E-6 1.777E-3 1.554E-2 2.666E-2 3 167
8 941 UP rottlerin; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 7.969E-6 1.777E-3 1.554E-2 2.812E-2 3 170
9 5026 UP Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 8.111E-6 1.777E-3 1.554E-2 2.862E-2 3 171
10 995 UP prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 8.399E-6 1.777E-3 1.554E-2 2.964E-2 3 173
11 949 UP 5255229; Up 200; 13uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 8.399E-6 1.777E-3 1.554E-2 2.964E-2 3 173
12 1141 UP AG-1478; Up 200; 31.6uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 9.941E-6 1.777E-3 1.554E-2 3.508E-2 3 183
13 3221 UP Metergoline [17692-51-2]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.941E-6 1.777E-3 1.554E-2 3.508E-2 3 183
14 4128 UP Azacytidine-5 [320-67-2]; Up 200; 16.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.027E-5 1.777E-3 1.554E-2 3.624E-2 3 185
15 6675 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.044E-5 1.777E-3 1.554E-2 3.683E-2 3 186
16 2218 UP Isoconazole [27523-40-6]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.061E-5 1.777E-3 1.554E-2 3.743E-2 3 187
17 5327 UP Benfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.130E-5 1.777E-3 1.554E-2 3.988E-2 3 191
18 4310 UP Dipyrone [5907-38-0]; Up 200; 12uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.184E-5 1.777E-3 1.554E-2 4.179E-2 3 194
19 4359 DN Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.221E-5 1.777E-3 1.554E-2 4.309E-2 3 196
20 4682 UP Clofazimine [2030-63-9]; Up 200; 8.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.221E-5 1.777E-3 1.554E-2 4.309E-2 3 196
21 7500 UP 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.240E-5 1.777E-3 1.554E-2 4.375E-2 3 197
22 6880 DN BAS 012416453; Down 200; 38uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.259E-5 1.777E-3 1.554E-2 4.442E-2 3 198
23 6481 DN Nilutamide [63612-50-0]; Down 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.259E-5 1.777E-3 1.554E-2 4.442E-2 3 198
24 6765 UP Ribostamycin sulfate salt [53797-35-6]; Up 200; 7.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.259E-5 1.777E-3 1.554E-2 4.442E-2 3 198
25 1670 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.259E-5 1.777E-3 1.554E-2 4.442E-2 3 198
26 CID000114822 AC1L3G0K Stitch 2.493E-5 3.384E-3 2.960E-2
8.799E-2
 2 30
27 CID000128814 AC1L2UHE Stitch 8.487E-5 1.084E-2
9.481E-2
2.995E-1
 2 55
28 ctd:D000841 Anisomycin CTD 2.081E-4 1.084E-2
9.481E-2
7.345E-1
 2 86
29 CID000010303 methyl red Stitch 2.081E-4 1.084E-2
9.481E-2
7.345E-1
 2 86
30 CID000360238 AC1L7G9I Stitch 2.627E-4 1.084E-2
9.481E-2
9.270E-1
 1 1
31 CID000007991 valerate Stitch 2.928E-4 1.084E-2
9.481E-2
1.000E0
 2 102
32 CID000005542 AC1L1KKT Stitch 3.529E-4 1.084E-2
9.481E-2
1.000E0
 2 112
33 CID000029051 NSC24559 Stitch 4.185E-4 1.084E-2
9.481E-2
1.000E0
 2 122
34 ctd:C035874 FG 7142 CTD 5.253E-4 1.084E-2
9.481E-2
1.000E0
 1 2
35 CID000327967 AC1L71LQ Stitch 5.428E-4 1.084E-2
9.481E-2
1.000E0
 2 139
36 6823 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.485E-4 1.084E-2
9.481E-2
1.000E0
 2 152
37 6807 UP Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.485E-4 1.084E-2
9.481E-2
1.000E0
 2 152
38 1068 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.742E-4 1.084E-2
9.481E-2
1.000E0
 2 155
39 1010 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.828E-4 1.084E-2
9.481E-2
1.000E0
 2 156
40 2651 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.916E-4 1.084E-2
9.481E-2
1.000E0
 2 157
41 1791 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.003E-4 1.084E-2
9.481E-2
1.000E0
 2 158
42 4136 UP Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.003E-4 1.084E-2
9.481E-2
1.000E0
 2 158
43 4325 UP Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.092E-4 1.084E-2
9.481E-2
1.000E0
 2 159
44 5275 UP Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.181E-4 1.084E-2
9.481E-2
1.000E0
 2 160
45 2896 UP Mometasone furoate [83919-23-7]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.181E-4 1.084E-2
9.481E-2
1.000E0
 2 160
46 2429 UP Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; HL60; HT HG-U133A Broad Institute CMAP Up 7.181E-4 1.084E-2
9.481E-2
1.000E0
 2 160
47 2886 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.270E-4 1.084E-2
9.481E-2
1.000E0
 2 161
48 2227 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.270E-4 1.084E-2
9.481E-2
1.000E0
 2 161
49 7340 UP Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.360E-4 1.084E-2
9.481E-2
1.000E0
 2 162
50 1498 UP Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.451E-4 1.084E-2
9.481E-2
1.000E0
 2 163
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 181 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 3.126E-4 2.226E-2
1.286E-1
5.658E-2
 3 414
2 C0866036 Postoperative peritoneal adhesions DisGeNET BeFree 3.703E-4 2.226E-2
1.286E-1
6.702E-2
 1 1
3 C0205698 Undifferentiated carcinoma DisGeNET BeFree 4.023E-4 2.226E-2
1.286E-1
7.282E-2
 2 85
4 C0014378 Enterovirus Infections DisGeNET Curated 4.919E-4 2.226E-2
1.286E-1
8.903E-2
 2 94
5 C0013949 Embryopathies DisGeNET BeFree 1.110E-3 4.020E-2
2.323E-1
2.010E-1
 1 3
6 C0861876 Recurrent Hepatocellular Carcinoma DisGeNET BeFree 1.480E-3 4.466E-2
2.580E-1
2.679E-1
 1 4
7 C1266134 Spindle cell rhabdomyosarcoma DisGeNET BeFree 1.850E-3 4.784E-2
2.764E-1
3.349E-1
 1 5
Show 2 more annotations