Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc415_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 33 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004407 histone deacetylase activity 1.727E-19 3.404E-18 1.392E-17 5.700E-18 7 42
2 GO:0033558 protein deacetylase activity 2.063E-19 3.404E-18 1.392E-17 6.809E-18 7 43
3 GO:0019213 deacetylase activity 3.543E-18 3.897E-17 1.593E-16 1.169E-16 7 63
4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4.784E-17 3.947E-16 1.614E-15 1.579E-15 7 90
5 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.711E-15 1.129E-14 4.617E-14 5.646E-14 7 148
6 GO:0031492 nucleosomal DNA binding 1.893E-10 1.041E-9 4.256E-9 6.246E-9 4 30
7 GO:0031491 nucleosome binding 1.027E-9 4.841E-9 1.980E-8 3.389E-8 4 45
8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 6.675E-9 2.753E-8 1.126E-7 2.203E-7 4 71
9 GO:0031490 chromatin DNA binding 1.388E-8 5.091E-8 2.082E-7 4.582E-7 4 85
10 GO:0001158 enhancer sequence-specific DNA binding 2.000E-8 6.600E-8 2.699E-7 6.600E-7 4 93
11 GO:0035326 enhancer binding 3.397E-8 1.019E-7 4.167E-7 1.121E-6 4 106
12 GO:0001103 RNA polymerase II repressing transcription factor binding 1.055E-7 2.900E-7 1.186E-6 3.480E-6 3 28
13 GO:0070491 repressing transcription factor binding 1.096E-6 2.782E-6 1.137E-5 3.617E-5 3 60
14 GO:0008094 DNA-dependent ATPase activity 4.134E-6 9.744E-6 3.984E-5 1.364E-4 3 93
15 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 5.585E-6 1.229E-5 5.024E-5 1.843E-4 4 379
16 GO:0000987 proximal promoter sequence-specific DNA binding 6.780E-6 1.398E-5 5.718E-5 2.238E-4 4 398
17 GO:0001085 RNA polymerase II transcription factor binding 8.469E-6 1.644E-5 6.722E-5 2.795E-4 3 118
18 GO:0004003 ATP-dependent DNA helicase activity 1.293E-4 2.371E-4 9.696E-4 4.268E-3 2 47
19 GO:0042623 ATPase activity, coupled 1.852E-4 3.217E-4 1.315E-3 6.113E-3 3 332
20 GO:0003678 DNA helicase activity 2.481E-4 4.093E-4 1.674E-3 8.186E-3 2 65
21 GO:0016887 ATPase activity 4.418E-4 6.943E-4 2.839E-3 1.458E-2 3 446
22 GO:0070035 purine NTP-dependent helicase activity 7.351E-4 1.047E-3 4.281E-3 2.426E-2 2 112
23 GO:0008026 ATP-dependent helicase activity 7.351E-4 1.047E-3 4.281E-3 2.426E-2 2 112
24 GO:0042826 histone deacetylase binding 7.615E-4 1.047E-3 4.281E-3 2.513E-2 2 114
25 GO:0004386 helicase activity 1.721E-3 2.271E-3 9.287E-3
5.678E-2
 2 172
26 GO:0008327 methyl-CpG binding 8.225E-3 1.044E-2 4.268E-2
2.714E-1
 1 22
Show 21 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 104 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016575 histone deacetylation 3.795E-17 3.947E-15 2.063E-14 3.947E-15 7 87
2 GO:0006476 protein deacetylation 1.040E-16 4.115E-15 2.151E-14 1.081E-14 7 100
3 GO:0035601 protein deacylation 1.478E-16 4.115E-15 2.151E-14 1.537E-14 7 105
4 GO:0098732 macromolecule deacylation 1.583E-16 4.115E-15 2.151E-14 1.646E-14 7 106
5 GO:1901796 regulation of signal transduction by p53 class mediator 3.302E-12 6.868E-11 3.590E-10 3.434E-10 6 167
6 GO:0016570 histone modification 4.383E-12 7.598E-11 3.971E-10 4.559E-10 7 447
7 GO:0016569 covalent chromatin modification 5.531E-12 8.217E-11 4.295E-10 5.752E-10 7 462
8 GO:0043044 ATP-dependent chromatin remodeling 1.931E-11 2.510E-10 1.312E-9 2.008E-9 5 75
9 GO:0072331 signal transduction by p53 class mediator 5.185E-11 5.992E-10 3.132E-9 5.393E-9 6 263
10 GO:0006338 chromatin remodeling 1.032E-9 1.073E-8 5.607E-8 1.073E-7 5 164
11 GO:0071103 DNA conformation change 1.660E-8 1.570E-7 8.204E-7 1.727E-6 5 285
12 GO:0006333 chromatin assembly or disassembly 3.438E-7 2.980E-6 1.557E-5 3.576E-5 4 188
13 GO:0040029 regulation of gene expression, epigenetic 1.357E-6 1.085E-5 5.672E-5 1.411E-4 4 265
14 GO:0045814 negative regulation of gene expression, epigenetic 1.334E-5 9.910E-5 5.180E-4 1.387E-3 3 137
15 GO:0006323 DNA packaging 4.518E-5 3.133E-4 1.637E-3 4.699E-3 3 206
16 GO:0061641 CENP-A containing chromatin organization 1.035E-4 6.334E-4 3.310E-3 1.077E-2 2 42
17 GO:0034080 CENP-A containing nucleosome assembly 1.035E-4 6.334E-4 3.310E-3 1.077E-2 2 42
18 GO:0031055 chromatin remodeling at centromere 1.244E-4 7.185E-4 3.755E-3 1.293E-2 2 46
19 GO:0006336 DNA replication-independent nucleosome assembly 1.654E-4 8.117E-4 4.242E-3 1.720E-2 2 53
20 GO:0034508 centromere complex assembly 1.654E-4 8.117E-4 4.242E-3 1.720E-2 2 53
21 GO:0034724 DNA replication-independent nucleosome organization 1.654E-4 8.117E-4 4.242E-3 1.720E-2 2 53
22 GO:0043486 histone exchange 1.717E-4 8.117E-4 4.242E-3 1.786E-2 2 54
23 GO:0006306 DNA methylation 2.647E-4 1.147E-3 5.994E-3 2.753E-2 2 67
24 GO:0006305 DNA alkylation 2.647E-4 1.147E-3 5.994E-3 2.753E-2 2 67
25 GO:0032508 DNA duplex unwinding 3.406E-4 1.417E-3 7.406E-3 3.542E-2 2 76
26 GO:0032392 DNA geometric change 3.869E-4 1.490E-3 7.788E-3 4.024E-2 2 81
27 GO:0044728 DNA methylation or demethylation 3.869E-4 1.490E-3 7.788E-3 4.024E-2 2 81
28 GO:0006304 DNA modification 6.008E-4 2.232E-3 1.166E-2
6.249E-2
 2 101
29 GO:1902499 positive regulation of protein autoubiquitination 7.516E-4 2.696E-3 1.409E-2
7.817E-2
 1 2
30 GO:1902498 regulation of protein autoubiquitination 1.127E-3 3.908E-3 2.042E-2
1.172E-1
 1 3
31 GO:0006334 nucleosome assembly 1.216E-3 4.078E-3 2.131E-2
1.264E-1
 2 144
32 GO:0007051 spindle organization 1.283E-3 4.171E-3 2.180E-2
1.335E-1
 2 148
33 GO:0070370 cellular heat acclimation 1.503E-3 4.694E-3 2.453E-2
1.563E-1
 1 4
34 GO:0031497 chromatin assembly 1.535E-3 4.694E-3 2.453E-2
1.596E-1
 2 162
35 GO:0034728 nucleosome organization 1.708E-3 5.075E-3 2.652E-2
1.776E-1
 2 171
36 GO:0072553 terminal button organization 1.878E-3 5.279E-3 2.759E-2
1.953E-1
 1 5
37 GO:0010286 heat acclimation 1.878E-3 5.279E-3 2.759E-2
1.953E-1
 1 5
38 GO:0065004 protein-DNA complex assembly 2.932E-3 8.025E-3 4.194E-2
3.050E-1
 2 225
39 GO:0071824 protein-DNA complex subunit organization 3.662E-3 9.766E-3
5.104E-2
3.809E-1
 2 252
40 GO:0043414 macromolecule methylation 4.283E-3 1.114E-2
5.820E-2
4.454E-1
 2 273
41 GO:0045475 locomotor rhythm 6.373E-3 1.617E-2
8.449E-2
6.628E-1
 1 17
42 GO:0006260 DNA replication 6.795E-3 1.671E-2
8.735E-2
7.067E-1
 2 346
43 GO:0032259 methylation 6.910E-3 1.671E-2
8.735E-2
7.187E-1
 2 349
44 GO:0043153 entrainment of circadian clock by photoperiod 7.121E-3 1.683E-2
8.797E-2
7.406E-1
 1 19
45 GO:0044030 regulation of DNA methylation 8.241E-3 1.905E-2
9.955E-2
8.571E-1
 1 22
46 GO:0009648 photoperiodism 8.988E-3 1.989E-2
1.039E-1
9.347E-1
 1 24
47 GO:0006346 methylation-dependent chromatin silencing 8.988E-3 1.989E-2
1.039E-1
9.347E-1
 1 24
48 GO:0009649 entrainment of circadian clock 9.734E-3 2.109E-2
1.102E-1
1.000E0
 1 26
49 GO:0018205 peptidyl-lysine modification 1.016E-2 2.156E-2
1.127E-1
1.000E0
 2 426
50 GO:0006335 DNA replication-dependent nucleosome assembly 1.197E-2 2.394E-2
1.251E-1
1.000E0
 1 32
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 23 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0090545 CHD-type complex 2.781E-22 3.198E-21 1.194E-20 6.397E-21 7 19
2 GO:0016581 NuRD complex 2.781E-22 3.198E-21 1.194E-20 6.397E-21 7 19
3 GO:0090568 nuclear transcriptional repressor complex 3.631E-21 2.783E-20 1.039E-19 8.350E-20 7 26
4 GO:0000118 histone deacetylase complex 3.054E-18 1.756E-17 6.557E-17 7.024E-17 7 63
5 GO:0070603 SWI/SNF superfamily-type complex 9.933E-18 4.569E-17 1.706E-16 2.284E-16 7 74
6 GO:0017053 transcriptional repressor complex 1.600E-17 6.133E-17 2.290E-16 3.680E-16 7 79
7 GO:0000790 nuclear chromatin 2.755E-6 9.052E-6 3.380E-5 6.336E-5 4 324
8 GO:0035098 ESC/E(Z) complex 1.384E-5 3.542E-5 1.323E-4 3.183E-4 2 16
9 GO:0000785 chromatin 1.386E-5 3.542E-5 1.323E-4 3.187E-4 4 487
10 GO:0031519 PcG protein complex 1.136E-4 2.613E-4 9.756E-4 2.613E-3 2 45
11 GO:0035097 histone methyltransferase complex 3.001E-4 6.274E-4 2.343E-3 6.901E-3 2 73
12 GO:0034708 methyltransferase complex 4.764E-4 9.130E-4 3.410E-3 1.096E-2 2 92
13 GO:0033186 CAF-1 complex 1.101E-3 1.949E-3 7.277E-3 2.533E-2 1 3
14 GO:0016589 NURF complex 2.202E-3 3.617E-3 1.351E-2
5.064E-2
 1 6
15 GO:0031010 ISWI-type complex 3.667E-3 5.623E-3 2.100E-2
8.435E-2
 1 10
16 GO:0016580 Sin3 complex 5.131E-3 7.376E-3 2.754E-2
1.180E-1
 1 14
17 GO:0070822 Sin3-type complex 6.227E-3 8.425E-3 3.146E-2
1.432E-1
 1 17
18 GO:0000792 heterochromatin 3.152E-2 4.028E-2
1.504E-1
7.250E-1
 1 87
Show 13 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 67 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 165 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 7 input genes in category / 89 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR012958 CHD N InterPro 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
2 IPR012957 CHD C2 InterPro 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
3 PF06465 DUF1087 Pfam 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
4 PF06461 DUF1086 Pfam 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
5 SM01147 DUF1087 SMART 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
6 PF12265 CAF1C H4-bd Pfam 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
7 IPR022052 Histone-bd RBBP4 N InterPro 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
8 PF08074 CHDCT2 Pfam 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
9 SM01146 DUF1086 SMART 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
10 IPR009462 DUF1086 InterPro 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
11 IPR009463 DUF1087 InterPro 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
12 PF08073 CHDNT Pfam 3.589E-7 2.662E-6 1.350E-5 3.194E-5 2 3
13 SM00439 BAH SMART 6.571E-6 3.655E-5 1.854E-4 5.848E-4 2 11
14 PF01426 BAH Pfam 6.571E-6 3.655E-5 1.854E-4 5.848E-4 2 11
15 PS51038 BAH PROSITE 6.571E-6 3.655E-5 1.854E-4 5.848E-4 2 11
16 IPR001025 BAH dom InterPro 6.571E-6 3.655E-5 1.854E-4 5.848E-4 2 11
17 SM00401 ZnF GATA SMART 7.884E-6 3.948E-5 2.002E-4 7.017E-4 2 12
18 SM01189 ELM2 SMART 9.316E-6 3.948E-5 2.002E-4 8.291E-4 2 13
19 IPR000949 ELM2 dom InterPro 9.316E-6 3.948E-5 2.002E-4 8.291E-4 2 13
20 PF01448 ELM2 Pfam 9.316E-6 3.948E-5 2.002E-4 8.291E-4 2 13
21 PS51156 ELM2 PROSITE 9.316E-6 3.948E-5 2.002E-4 8.291E-4 2 13
22 PF00320 GATA Pfam 1.254E-5 4.851E-5 2.460E-4 1.116E-3 2 15
23 IPR000679 Znf GATA InterPro 1.254E-5 4.851E-5 2.460E-4 1.116E-3 2 15
24 PS50114 GATA ZN FINGER 2 PROSITE 1.432E-5 5.099E-5 2.586E-4 1.275E-3 2 16
25 PS00344 GATA ZN FINGER 1 PROSITE 1.432E-5 5.099E-5 2.586E-4 1.275E-3 2 16
26 IPR023780 Chromo domain InterPro 3.290E-5 1.126E-4 5.711E-4 2.928E-3 2 24
27 IPR017884 SANT dom InterPro 3.873E-5 1.231E-4 6.242E-4 3.447E-3 2 26
28 PF00385 Chromo Pfam 3.873E-5 1.231E-4 6.242E-4 3.447E-3 2 26
29 PS51293 SANT PROSITE 4.502E-5 1.293E-4 6.556E-4 4.007E-3 2 28
30 PS50013 CHROMO 2 PROSITE 4.502E-5 1.293E-4 6.556E-4 4.007E-3 2 28
31 PS00598 CHROMO 1 PROSITE 4.502E-5 1.293E-4 6.556E-4 4.007E-3 2 28
32 IPR000330 SNF2 N InterPro 5.904E-5 1.545E-4 7.837E-4 5.254E-3 2 32
33 IPR016197 Chromodomain-like InterPro 5.904E-5 1.545E-4 7.837E-4 5.254E-3 2 32
34 PF00176 SNF2 N Pfam 5.904E-5 1.545E-4 7.837E-4 5.254E-3 2 32
35 SM00298 CHROMO SMART 6.284E-5 1.553E-4 7.878E-4 5.592E-3 2 33
36 IPR000953 Chromo/shadow dom InterPro 6.284E-5 1.553E-4 7.878E-4 5.592E-3 2 33
37 IPR002464 DNA/RNA helicase DEAH CS InterPro 7.078E-5 1.658E-4 8.408E-4 6.300E-3 2 35
38 PF00249 Myb DNA-binding Pfam 7.078E-5 1.658E-4 8.408E-4 6.300E-3 2 35
39 PS00690 DEAH ATP HELICASE PROSITE 8.359E-5 1.860E-4 9.432E-4 7.439E-3 2 38
40 PS50090 MYB LIKE PROSITE 8.359E-5 1.860E-4 9.432E-4 7.439E-3 2 38
41 SM00717 SANT SMART 1.453E-4 3.155E-4 1.600E-3 1.294E-2 2 50
42 IPR001005 SANT/Myb InterPro 1.573E-4 3.333E-4 1.690E-3 1.400E-2 2 52
43 IPR009071 HMG box dom InterPro 2.461E-4 4.978E-4 2.525E-3 2.191E-2 2 65
44 IPR019786 Zinc finger PHD-type CS InterPro 2.461E-4 4.978E-4 2.525E-3 2.191E-2 2 65
45 PF00628 PHD Pfam 3.278E-4 6.483E-4 3.288E-3 2.917E-2 2 75
46 IPR019787 Znf PHD-finger InterPro 3.637E-4 6.928E-4 3.513E-3 3.237E-2 2 79
47 IPR028722 CHD3 InterPro 3.736E-4 6.928E-4 3.513E-3 3.325E-2 1 1
48 IPR028725 CHD4 InterPro 3.736E-4 6.928E-4 3.513E-3 3.325E-2 1 1
49 IPR020472 G-protein beta WD-40 rep InterPro 4.209E-4 7.646E-4 3.877E-3 3.746E-2 2 85
50 SM00249 PHD SMART 4.614E-4 8.213E-4 4.165E-3 4.106E-2 2 89
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 43 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269660 RNA Polymerase I Transcription Initiation BioSystems: REACTOME 8.017E-18 3.447E-16 1.500E-15 3.447E-16 7 48
2 1383084 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression BioSystems: REACTOME 2.619E-16 5.630E-15 2.449E-14 1.126E-14 7 77
3 1383083 Regulation of TP53 Activity through Acetylation BioSystems: REACTOME 9.959E-16 1.198E-14 5.212E-14 4.283E-14 6 31
4 1270436 HDACs deacetylate histones BioSystems: REACTOME 1.115E-15 1.198E-14 5.212E-14 4.793E-14 7 94
5 1339125 Positive epigenetic regulation of rRNA expression BioSystems: REACTOME 3.244E-15 2.583E-14 1.124E-13 1.395E-13 7 109
6 1269658 RNA Polymerase I Promoter Clearance BioSystems: REACTOME 3.698E-15 2.583E-14 1.124E-13 1.590E-13 7 111
7 1269657 RNA Polymerase I Transcription BioSystems: REACTOME 4.205E-15 2.583E-14 1.124E-13 1.808E-13 7 113
8 1269656 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription BioSystems: REACTOME 3.358E-14 1.682E-13 7.316E-13 1.444E-12 7 151
9 1269734 Epigenetic regulation of gene expression BioSystems: REACTOME 3.520E-14 1.682E-13 7.316E-13 1.514E-12 7 152
10 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 1.226E-13 5.272E-13 2.293E-12 5.272E-12 6 66
11 1270433 Chromatin organization BioSystems: REACTOME 2.635E-12 9.443E-12 4.108E-11 1.133E-10 7 279
12 1270434 Chromatin modifying enzymes BioSystems: REACTOME 2.635E-12 9.443E-12 4.108E-11 1.133E-10 7 279
13 1383076 Regulation of TP53 Activity BioSystems: REACTOME 3.064E-11 1.014E-10 4.409E-10 1.318E-9 6 162
14 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 4.821E-9 1.481E-8 6.442E-8 2.073E-7 6 374
15 M225 Downregulated of MTA-3 in ER-negative Breast Tumors MSigDB C2 BIOCARTA (v6.0) 4.613E-5 1.322E-4 5.752E-4 1.984E-3 2 19
16 137912 Hedgehog signaling events mediated by Gli proteins BioSystems: Pathway Interaction Database 2.535E-4 6.812E-4 2.963E-3 1.090E-2 2 44
17 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 5.714E-4 1.445E-3 6.287E-3 2.457E-2 2 66
18 1270438 PKMTs methylate histone lysines BioSystems: REACTOME 6.987E-4 1.502E-3 6.535E-3 3.005E-2 2 73
19 1269855 Deposition of new CENPA-containing nucleosomes at the centromere BioSystems: REACTOME 6.987E-4 1.502E-3 6.535E-3 3.005E-2 2 73
20 1269854 Nucleosome assembly BioSystems: REACTOME 6.987E-4 1.502E-3 6.535E-3 3.005E-2 2 73
21 1269735 PRC2 methylates histones and DNA BioSystems: REACTOME 7.374E-4 1.510E-3 6.568E-3 3.171E-2 2 75
22 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 7.771E-4 1.519E-3 6.607E-3 3.342E-2 2 77
23 1269853 Chromosome Maintenance BioSystems: REACTOME 1.578E-3 2.951E-3 1.283E-2
6.786E-2
 2 110
24 1339139 Activation of HOX genes during differentiation BioSystems: REACTOME 2.097E-3 3.468E-3 1.508E-2
9.016E-2
 2 127
25 1339140 Activation of anterior HOX genes in hindbrain development during early embryogenesis BioSystems: REACTOME 2.097E-3 3.468E-3 1.508E-2
9.016E-2
 2 127
26 1270428 Oxidative Stress Induced Senescence BioSystems: REACTOME 2.097E-3 3.468E-3 1.508E-2
9.016E-2
 2 127
27 1270426 Cellular Senescence BioSystems: REACTOME 4.965E-3 7.907E-3 3.439E-2
2.135E-1
 2 197
28 1269804 Polo-like kinase mediated events BioSystems: REACTOME 9.521E-3 1.412E-2
6.141E-2
4.094E-1
 1 17
29 1339110 SUMOylation of transcription factors BioSystems: REACTOME 9.521E-3 1.412E-2
6.141E-2
4.094E-1
 1 17
30 1269765 G0 and Early G1 BioSystems: REACTOME 1.398E-2 2.003E-2
8.714E-2
6.009E-1
 1 25
31 1270414 Cellular responses to stress BioSystems: REACTOME 2.467E-2 3.422E-2
1.489E-1
1.000E0
 2 454
32 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 3.107E-2 4.175E-2
1.816E-1
1.000E0
 1 56
Show 27 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 789 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19703393 LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Pubmed 7.300E-26 5.759E-23 4.175E-22 5.759E-23 7 13
2 10444591 Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Pubmed 2.737E-25 1.080E-22 7.828E-22 2.160E-22 7 15
3 20127688 Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress. Pubmed 3.411E-22 6.728E-20 4.877E-19 2.691E-19 6 10
4 16091750 BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. Pubmed 3.411E-22 6.728E-20 4.877E-19 2.691E-19 6 10
5 15456747 MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. Pubmed 7.504E-22 1.184E-19 8.583E-19 5.921E-19 6 11
6 9885572 NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Pubmed 1.501E-21 1.974E-19 1.431E-18 1.184E-18 6 12
7 9804427 Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Pubmed 4.877E-21 4.810E-19 3.487E-18 3.848E-18 6 14
8 25150861 NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Pubmed 4.877E-21 4.810E-19 3.487E-18 3.848E-18 6 14
9 15701600 MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. Pubmed 8.129E-21 6.413E-19 4.649E-18 6.413E-18 6 15
10 25247294 The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. Pubmed 8.129E-21 6.413E-19 4.649E-18 6.413E-18 6 15
11 12493763 A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. Pubmed 3.015E-20 2.162E-18 1.567E-17 2.379E-17 6 18
12 21670149 Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Pubmed 1.639E-19 1.078E-17 7.812E-17 1.293E-16 6 23
13 17626165 Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Pubmed 1.861E-19 1.129E-17 8.187E-17 1.468E-16 5 6
14 11297506 The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Pubmed 1.737E-18 8.060E-17 5.843E-16 1.370E-15 5 8
15 18182442 Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex. Pubmed 1.737E-18 8.060E-17 5.843E-16 1.370E-15 5 8
16 10471500 Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Pubmed 1.737E-18 8.060E-17 5.843E-16 1.370E-15 5 8
17 12705869 MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Pubmed 1.737E-18 8.060E-17 5.843E-16 1.370E-15 5 8
18 22926524 RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Pubmed 3.907E-18 1.713E-16 1.242E-15 3.083E-15 5 9
19 21258344 Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Pubmed 1.322E-17 5.490E-16 3.979E-15 1.043E-14 6 45
20 20720167 Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Pubmed 1.433E-17 5.652E-16 4.097E-15 1.130E-14 5 11
21 23708667 The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Pubmed 2.456E-17 8.807E-16 6.384E-15 1.938E-14 5 12
22 21937684 Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Pubmed 2.456E-17 8.807E-16 6.384E-15 1.938E-14 5 12
23 21532573 Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Pubmed 3.725E-17 1.211E-15 8.778E-15 2.939E-14 6 53
24 12124384 The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. Pubmed 3.990E-17 1.211E-15 8.778E-15 3.148E-14 5 13
25 9790534 The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Pubmed 3.990E-17 1.211E-15 8.778E-15 3.148E-14 5 13
26 12920132 The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. Pubmed 3.990E-17 1.211E-15 8.778E-15 3.148E-14 5 13
27 20585571 Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. Pubmed 6.207E-17 1.749E-15 1.268E-14 4.897E-14 5 14
28 15920471 GATA-1 forms distinct activating and repressive complexes in erythroid cells. Pubmed 6.207E-17 1.749E-15 1.268E-14 4.897E-14 5 14
29 27806305 A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Pubmed 1.354E-16 3.561E-15 2.582E-14 1.068E-13 5 16
30 11102443 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. Pubmed 1.354E-16 3.561E-15 2.582E-14 1.068E-13 5 16
31 23281010 Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. Pubmed 1.918E-16 4.882E-15 3.539E-14 1.514E-13 5 17
32 23201013 Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development. Pubmed 2.656E-16 6.549E-15 4.747E-14 2.096E-13 5 18
33 23752268 The functional interactome landscape of the human histone deacetylase family. Pubmed 1.257E-15 3.007E-14 2.179E-13 9.922E-13 7 287
34 16462733 The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Pubmed 1.974E-15 4.581E-14 3.321E-13 1.558E-12 4 5
35 20547755 Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. Pubmed 5.922E-15 1.335E-13 9.676E-13 4.672E-12 4 6
36 18067919 The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. Pubmed 2.763E-14 6.056E-13 4.390E-12 2.180E-11 4 8
37 20362541 An Oct4-centered protein interaction network in embryonic stem cells. Pubmed 3.563E-14 7.599E-13 5.508E-12 2.812E-11 6 161
38 22770845 The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Pubmed 4.244E-14 8.812E-13 6.387E-12 3.349E-11 5 46
39 11756549 Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Pubmed 4.973E-14 1.006E-12 7.293E-12 3.924E-11 4 9
40 27705803 A High-Density Map for Navigating the Human Polycomb Complexome. Pubmed 5.890E-14 1.162E-12 8.421E-12 4.647E-11 7 495
41 19644445 ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. Pubmed 8.288E-14 1.595E-12 1.156E-11 6.540E-11 4 10
42 19454010 In vitro nuclear interactome of the HIV-1 Tat protein. Pubmed 1.143E-13 2.147E-12 1.556E-11 9.017E-11 6 195
43 20362542 An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pubmed 1.437E-12 2.637E-11 1.911E-10 1.134E-9 5 91
44 16217013 Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Pubmed 1.529E-12 2.742E-11 1.987E-10 1.206E-9 4 19
45 27773593 FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Pubmed 1.911E-12 3.351E-11 2.429E-10 1.508E-9 4 20
46 18454139 Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Pubmed 2.361E-12 3.963E-11 2.872E-10 1.862E-9 4 21
47 12453419 ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Pubmed 2.361E-12 3.963E-11 2.872E-10 1.862E-9 4 21
48 19394292 Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Pubmed 3.129E-12 5.144E-11 3.729E-10 2.469E-9 5 106
49 27144666 The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7. Pubmed 3.770E-12 6.070E-11 4.400E-10 2.974E-9 3 3
50 22325351 Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Pubmed 1.828E-11 2.884E-10 2.090E-9 1.442E-8 4 34
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 1070 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MBD3L1 MBD3L1 interactions 4.451E-21 2.173E-18 1.641E-17 4.763E-18 7 25
2 int:CHD5 CHD5 interactions 6.091E-21 2.173E-18 1.641E-17 6.518E-18 7 26
3 int:BCL11B BCL11B interactions 6.091E-21 2.173E-18 1.641E-17 6.518E-18 7 26
4 int:BCL11A BCL11A interactions 4.982E-20 1.333E-17 1.007E-16 5.330E-17 7 34
5 int:MBD3L2 MBD3L2 interactions 7.569E-20 1.620E-17 1.223E-16 8.099E-17 6 11
6 int:MBD2 MBD2 interactions 1.239E-18 2.182E-16 1.648E-15 1.326E-15 7 52
7 int:ZNF219 ZNF219 interactions 1.427E-18 2.182E-16 1.648E-15 1.527E-15 7 53
8 int:CDK2AP1 CDK2AP1 interactions 1.879E-18 2.513E-16 1.898E-15 2.011E-15 7 55
9 int:GATAD2A GATAD2A interactions 3.576E-18 4.252E-16 3.211E-15 3.827E-15 7 60
10 int:ZNF827 ZNF827 interactions 8.886E-18 9.508E-16 7.182E-15 9.508E-15 6 21
11 int:MTA3 MTA3 interactions 1.364E-17 1.327E-15 1.002E-14 1.460E-14 7 72
12 int:MBD3 MBD3 interactions 8.112E-17 7.221E-15 5.454E-14 8.680E-14 7 92
13 int:GATAD2B GATAD2B interactions 8.773E-17 7.221E-15 5.454E-14 9.387E-14 7 93
14 int:NR2C1 NR2C1 interactions 9.719E-17 7.428E-15 5.611E-14 1.040E-13 6 30
15 int:PHF20L1 PHF20L1 interactions 1.813E-16 1.293E-14 9.766E-14 1.940E-13 6 33
16 int:MTA1 MTA1 interactions 7.384E-16 4.938E-14 3.730E-13 7.901E-13 7 125
17 int:MTA2 MTA2 interactions 2.474E-15 1.557E-13 1.176E-12 2.648E-12 7 148
18 int:NACC2 NACC2 interactions 2.901E-15 1.724E-13 1.302E-12 3.104E-12 5 14
19 int:SALL4 SALL4 interactions 5.308E-15 2.989E-13 2.258E-12 5.679E-12 6 56
20 int:ZMYND8 ZMYND8 interactions 8.183E-15 4.378E-13 3.307E-12 8.756E-12 6 60
21 int:RBBP7 RBBP7 interactions 2.041E-14 1.040E-12 7.854E-12 2.184E-11 7 199
22 int:SIN3A SIN3A interactions 6.066E-14 2.950E-12 2.228E-11 6.491E-11 7 232
23 int:RBBP4 RBBP4 interactions 6.447E-14 2.999E-12 2.265E-11 6.898E-11 7 234
24 int:L3MBTL2 L3MBTL2 interactions 2.196E-13 9.792E-12 7.396E-11 2.350E-10 6 102
25 int:DNMT1 DNMT1 interactions 4.119E-13 1.763E-11 1.332E-10 4.407E-10 6 113
26 int:SOX2 SOX2 interactions 1.555E-12 6.284E-11 4.746E-10 1.664E-9 7 367
27 int:KDM1A KDM1A interactions 1.586E-12 6.284E-11 4.746E-10 1.697E-9 7 368
28 int:HDAC2 HDAC2 interactions 1.916E-12 7.321E-11 5.530E-10 2.050E-9 7 378
29 int:PARK7 PARK7 interactions 7.546E-12 2.784E-10 2.103E-9 8.075E-9 6 182
30 int:KDM5B KDM5B interactions 1.392E-11 4.966E-10 3.751E-9 1.490E-8 5 67
31 int:PCNT PCNT interactions 1.620E-11 5.591E-10 4.223E-9 1.733E-8 5 69
32 int:SUMO2 SUMO2 interactions 2.016E-11 6.591E-10 4.978E-9 2.157E-8 6 214
33 int:TCF19 TCF19 interactions 2.033E-11 6.591E-10 4.978E-9 2.175E-8 4 17
34 int:ZNF512B ZNF512B interactions 3.040E-11 9.568E-10 7.227E-9 3.253E-8 5 78
35 int:ZFPM1 ZFPM1 interactions 3.309E-11 1.012E-9 7.642E-9 3.541E-8 4 19
36 int:ZFPM2 ZFPM2 interactions 4.136E-11 1.229E-9 9.285E-9 4.426E-8 4 20
37 int:DNMT3B DNMT3B interactions 4.721E-11 1.365E-9 1.031E-8 5.051E-8 5 85
38 int:HIST3H3 HIST3H3 interactions 6.254E-11 1.761E-9 1.330E-8 6.691E-8 6 258
39 int:TFCP2L1 TFCP2L1 interactions 7.893E-11 2.166E-9 1.636E-8 8.446E-8 5 94
40 int:GATA1 GATA1 interactions 1.028E-10 2.750E-9 2.077E-8 1.100E-7 5 99
41 int:ZEB2 ZEB2 interactions 1.275E-10 3.328E-9 2.514E-8 1.364E-7 4 26
42 int:KMT2A KMT2A interactions 2.203E-10 5.611E-9 4.238E-8 2.357E-7 5 115
43 int:CPNE5 CPNE5 interactions 3.065E-10 7.453E-9 5.629E-8 3.279E-7 4 32
44 int:HIC1 HIC1 interactions 3.065E-10 7.453E-9 5.629E-8 3.279E-7 4 32
45 int:IKZF1 IKZF1 interactions 3.644E-10 8.666E-9 6.545E-8 3.900E-7 5 127
46 int:FOXK2 FOXK2 interactions 5.155E-10 1.199E-8 9.058E-8 5.516E-7 5 136
47 int:ZNF296 ZNF296 interactions 7.568E-10 1.723E-8 1.301E-7 8.097E-7 3 6
48 int:SMARCA5 SMARCA5 interactions 8.751E-10 1.951E-8 1.473E-7 9.364E-7 5 151
49 int:PHF6 PHF6 interactions 1.958E-9 4.190E-8 3.165E-7 2.095E-6 4 50
50 int:TWIST1 TWIST1 interactions 1.958E-9 4.190E-8 3.165E-7 2.095E-6 4 50
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q12-q13.1 11q12-q13.1 1.211E-3 7.063E-3 1.831E-2 8.478E-3 1 6
2 14q32.3 14q32.3 2.018E-3 7.063E-3 1.831E-2 1.413E-2 1 10
3 1p35.1 1p35.1 6.445E-3 1.479E-2 3.835E-2 4.512E-2 1 32
4 Xp22.2 Xp22.2 8.452E-3 1.479E-2 3.835E-2
5.916E-2
 1 42
5 12p13 12p13 1.325E-2 1.856E-2 4.811E-2
9.278E-2
 1 66
6 17p13.1 17p13.1 2.438E-2 2.845E-2
7.376E-2
1.707E-1
 1 122
7 19p13.3 19p13.3 4.883E-2 4.883E-2
1.266E-1
3.418E-1
 1 247
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 113 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1305 Histone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex genenames.org 6.056E-24 5.450E-23 1.542E-22 5.450E-23 7 12
2 1347 Lysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2 genenames.org 1.902E-6 8.559E-6 2.421E-5 1.712E-5 2 6
3 1306 EMSY complex|SIN3 histone deacetylase complex genenames.org 4.562E-6 1.369E-5 3.872E-5 4.106E-5 2 9
4 1243 EMSY complex genenames.org 8.359E-6 1.881E-5 5.321E-5 7.523E-5 2 12
5 82 GATA zinc finger domain containing genenames.org 1.329E-5 2.392E-5 6.768E-5 1.196E-4 2 15
6 532 GATA zinc finger domain containing|Myb/SANT domain containing genenames.org 1.732E-4 2.598E-4 7.351E-4 1.559E-3 2 53
7 88 Zinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases genenames.org 5.000E-4 6.429E-4 1.819E-3 4.500E-3 2 90
8 362 Ring finger proteins|WD repeat domain containing genenames.org 4.136E-3 4.225E-3 1.195E-2 3.722E-2 2 262
9 1025 Methyl-CpG binding domain containing|NuRD complex genenames.org 4.225E-3 4.225E-3 1.195E-2 3.803E-2 1 11
Show 4 more annotations

13: Coexpression [Display Chart] 7 input genes in category / 634 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15604209-Table1a Human Uterine Luo05 110genes 2Hr GeneSigDB 2.960E-6 1.877E-3 1.319E-2 1.877E-3 3 103
2 16121216-TableS1 Human Leukemia Bradbury05 23genes AssociatedProteinsPMBC GeneSigDB 1.643E-5 3.473E-3 2.441E-2 1.042E-2 2 21
3 16121216-TableS2 Human Leukemia Bradbury05 23genes RelatedProteinsMC GeneSigDB 1.643E-5 3.473E-3 2.441E-2 1.042E-2 2 21
4 16254190-Table2 Mouse Skin Zhang05 74genes GeneSigDB 1.770E-4 2.312E-2
1.625E-1
1.122E-1
 2 68
5 M836 Genes up-regulated in pirmary cultures of epithelial ovarian cancer (EOC): invasive (TOV) vs low malignant potential (LMP) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.823E-4 2.312E-2
1.625E-1
1.156E-1
 2 69
6 M2208 Potential targets of MIR302A [GeneID=407028]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.271E-4 2.400E-2
1.687E-1
1.440E-1
 2 77
7 M14665 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.883E-4 2.532E-2
1.780E-1
1.828E-1
 3 478
8 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.906E-4 2.532E-2
1.780E-1
2.476E-1
 2 101
9 15940270-Figure2D Human Ovarian Ouellet05 116genes GeneSigDB 4.548E-4 2.532E-2
1.780E-1
2.883E-1
 2 109
10 M8880 Genes down-regulated during pubertal mammary gland development between week 5 and 6. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.168E-4 2.532E-2
1.780E-1
4.545E-1
 2 137
11 12925741-Figure8 Human Lymphoma Jenner03 279genes GeneSigDB 8.927E-4 2.532E-2
1.780E-1
5.660E-1
 2 153
12 M5655 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 1.113E-3 2.532E-2
1.780E-1
7.056E-1
 2 171
13 14966907-table3 Human Liver Song04 4genes GeneSigDB 1.210E-3 2.532E-2
1.780E-1
7.670E-1
 1 4
14 M6732 Genes up-regulated in B lymphocytes versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.443E-3 2.532E-2
1.780E-1
9.151E-1
 2 195
15 M2155 Genes up-regulated during pubertal mammary gland development between week 6 and 7. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.473E-3 2.532E-2
1.780E-1
9.337E-1
 2 197
16 M5256 Genes up-regulated in comparison of macrophages exposed to T. gondii versus macrophages exposed to 5 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 2.532E-2
1.780E-1
9.431E-1
 2 198
17 M8571 Genes down-regulated in T helper cells 15 days post polarization and stimulated with anti-CD3 and anti-CD28: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.532E-2
1.780E-1
9.525E-1
 2 199
18 M8148 Genes down-regulated in HEK293 cells at 6h after stimulation by muramyl dipeptide [PubChem=11620162]: over-expressing mutant NOD2 [GeneID=64127] versus control. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.532E-2
1.780E-1
9.525E-1
 2 199
19 M4300 Genes down-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] high T cells at. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
20 M7077 Genes up-regulated in CD4 [GeneID=920] T cells from atopic patients: resting versus stimulated with allergen (house dust mite). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
21 M7350 Genes down-regulated in HMC-1 (mast leukemia) cells: incubated with the peptide ALL1 versus stimulated with T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
22 M8569 Genes up-regulated in Th1 cells 15 days post polarization: control versus stimulated with anti-CD3 and anti-CD28. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
23 M6262 Genes up-regulated in CD8 T cells: healthy versus CLL (chronic lymphocytic leukemia). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
24 M8312 Genes up-regulated in activated T cells: CD4 [GeneID=920] versus NKT. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
25 M7058 Genes down-regulated in lymphoid-primed multipotent progenitors: wildtype versus IKZF1 [GeneID=10320] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
26 M3407 Genes up-regulated in comparison of control microglia cells versus those 24 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
27 M5220 Genes up-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus DCs exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
28 M3769 Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
29 M7840 Genes down-regulated in resting T reg versus T conv cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
30 M3073 Genes up-regulated in comparison of memory CD8 T cells versus effector CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
31 M3379 Genes down-regulated in comparison of Th1 cells versus induced regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
32 M3197 Genes down-regulated in comparison of IgD- peripheral blood B cells versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
33 M5188 Genes down-regulated in comparison of dendritic cells (DC) exposed to 5 worm/well B. malayi versus macrophages exposed to 5 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
34 M7904 Genes down-regulated in monocytes (12h) versus macrophages (12h) treated with IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
35 M9652 Genes up-regulated in CD4 [GeneID=920] T helper cells (52h): Th0 versus Th17 treated with TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
36 M5602 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus those treated witl IL1B [GeneID=3553], IL6 [GeneID=3569] and IL23A [GeneID=51561]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
37 M7097 Genes down-regulated in CD4 [GeneID=920] T cells stimulated with allergen (house dust mite): atopy versus healthy. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
38 M3459 Genes up-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.532E-2
1.780E-1
9.620E-1
 2 200
39 17894856-SuppList4 Human Breast Yu07 298genes GeneSigDB 1.671E-3 2.716E-2
1.910E-1
1.000E0
 2 210
40 M1180 Candidate substrate proteins of AURKA [GeneID=6790]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.814E-3 2.875E-2
2.021E-1
1.000E0
 1 6
41 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.999E-3 3.092E-2
2.174E-1
1.000E0
 2 230
42 M2563 Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive ALL (B- and T-lineage ALL); here - genes up-regulated in the drug resistant samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.116E-3 3.194E-2
2.246E-1
1.000E0
 1 7
43 15650054-Table2 Human Lymphoma Ghobrial05 13genes GeneSigDB 2.418E-3 3.565E-2
2.506E-1
1.000E0
 1 8
44 M14648 Genes down-regulated in EVSA-T cells (breast cancer) treated with 3 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 8 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.258E-2
2.993E-1
1.000E0
 1 10
45 M2556 Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.258E-2
2.993E-1
1.000E0
 1 10
46 14767473-SuppTable2 Human Pancreas Nakamura04 346genes GeneSigDB 3.240E-3 4.465E-2
3.139E-1
1.000E0
 2 294
47 11906190-Table2b-1 Human Colon Iizaka02 14genes GeneSigDB 3.625E-3 4.890E-2
3.438E-1
1.000E0
 1 12
Show 42 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 439 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C4-KC3 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C4-KC3 Top 200 Genes 1.125E-4 4.939E-2
3.291E-1
 4.939E-2 3 328

15: Computational [Display Chart] 7 input genes in category / 81 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.652E-5 2.148E-3 1.069E-2 2.148E-3 4 303
2 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.376E-5 2.987E-3 1.487E-2 5.975E-3 4 393
3 M16797 MODULE 318 Genes in the cancer module 318. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.563E-4 4.219E-3 2.100E-2 1.266E-2 2 28
4 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.521E-3 3.079E-2
1.533E-1
1.232E-1
 3 367

16: MicroRNA [Display Chart] 7 input genes in category / 413 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-661:Functional MTI Functional MTI miRTarbase 8.752E-6 2.553E-3 1.685E-2 3.614E-3 3 459
2 TCCCCAC,MIR-491:MSigDB TCCCCAC,MIR-491:MSigDB MSigDB 1.236E-5 2.553E-3 1.685E-2 5.106E-3 2 56
3 hsa-miR-323-5p:PITA hsa-miR-323-5p:PITA TOP PITA 2.347E-5 3.231E-3 2.133E-2 9.692E-3 2 77
4 hsa-miR-491-5p:PITA hsa-miR-491-5p:PITA TOP PITA 4.542E-5 4.690E-3 3.096E-2 1.876E-2 2 107
5 hsa-miR-661:PITA hsa-miR-661:PITA TOP PITA 9.538E-5 4.840E-3 3.195E-2 3.939E-2 2 155
6 hsa-miR-873-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.004E-4 4.840E-3 3.195E-2 4.145E-2 2 159
7 hsa-miR-579-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.016E-4 4.840E-3 3.195E-2 4.197E-2 2 160
8 hsa-miR-664b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.042E-4 4.840E-3 3.195E-2 4.303E-2 2 162
9 hsa-miR-5696:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.055E-4 4.840E-3 3.195E-2 4.356E-2 2 163
10 hsa-miR-486-3p:Functional MTI Functional MTI miRTarbase 1.619E-4 6.199E-3 4.092E-2
6.686E-2
 2 202
11 hsa-miR-559:Functional MTI Functional MTI miRTarbase 1.651E-4 6.199E-3 4.092E-2
6.818E-2
 2 204
12 hsa-miR-423-3p:Functional MTI Functional MTI miRTarbase 2.097E-4 7.218E-3 4.765E-2
8.662E-2
 2 230
13 hsa-miR-194:PITA hsa-miR-194:PITA TOP PITA 2.908E-4 9.239E-3
6.099E-2
1.201E-1
 2 271
14 hsa-miR-652:mirSVR lowEffct hsa-miR-652:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.998E-4 1.042E-2
6.876E-2
1.651E-1
 2 318
15 hsa-miR-3672:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.149E-4 1.042E-2
6.876E-2
1.714E-1
 2 324
16 hsa-miR-6864-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.149E-4 1.042E-2
6.876E-2
1.714E-1
 2 324
17 hsa-miR-194-5p:TargetScan hsa-miR-194-5p TargetScan 4.303E-4 1.042E-2
6.876E-2
1.777E-1
 2 330
18 hsa-miR-6851-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.540E-4 1.042E-2
6.876E-2
1.875E-1
 2 339
19 hsa-miR-3689d:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.975E-4 1.056E-2
6.974E-2
2.055E-1
 2 355
20 hsa-miR-6134:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.115E-4 1.056E-2
6.974E-2
2.113E-1
 2 360
21 hsa-miR-1252:PITA hsa-miR-1252:PITA TOP PITA 5.430E-4 1.068E-2
7.051E-2
2.243E-1
 2 371
22 hsa-miR-7-5p:TargetScan hsa-miR-7-5p TargetScan 6.463E-4 1.212E-2
8.003E-2
2.669E-1
 2 405
23 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 6.751E-4 1.212E-2
8.003E-2
2.788E-1
 2 414
24 hsa-miR-135b*:mirSVR highEffct hsa-miR-135b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.651E-4 1.245E-2
8.220E-2
3.160E-1
 2 441
25 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 7.686E-4 1.245E-2
8.220E-2
3.174E-1
 2 442
26 hsa-miR-92b*:mirSVR lowEffct hsa-miR-92b*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.034E-4 1.245E-2
8.220E-2
3.318E-1
 2 452
27 hsa-miR-4252:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.140E-4 1.245E-2
8.220E-2
3.362E-1
 2 455
28 hsa-miR-886-5p:PITA hsa-miR-886-5p:PITA TOP PITA 1.162E-3 1.714E-2
1.132E-1
4.800E-1
 1 12
29 hsa-miR-147b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.033E-3 2.896E-2
1.912E-1
8.397E-1
 1 21
30 hsa-miR-887:PITA hsa-miR-887:PITA TOP PITA 2.323E-3 3.198E-2
2.112E-1
9.595E-1
 1 24
31 hsa-miR-1204:PITA hsa-miR-1204:PITA TOP PITA 2.420E-3 3.224E-2
2.129E-1
9.995E-1
 1 25
32 hsa-miR-6746-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.807E-3 3.564E-2
2.353E-1
1.000E0
 1 29
33 hsa-miR-5092:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.193E-3 3.564E-2
2.353E-1
1.000E0
 1 33
34 hsa-miR-4999-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.580E-3 3.564E-2
2.353E-1
1.000E0
 1 37
35 hsa-miR-4766-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 3.564E-2
2.353E-1
1.000E0
 1 38
36 hsa-miR-4288:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 3.564E-2
2.353E-1
1.000E0
 1 38
37 hsa-miR-632:Functional MTI Functional MTI miRTarbase 3.966E-3 3.564E-2
2.353E-1
1.000E0
 1 41
38 hsa-miR-6069:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.564E-2
2.353E-1
1.000E0
 1 42
39 hsa-miR-6772-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.564E-2
2.353E-1
1.000E0
 1 42
40 hsa-miR-6767-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.352E-3 3.564E-2
2.353E-1
1.000E0
 1 45
41 hsa-miR-4774-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.449E-3 3.564E-2
2.353E-1
1.000E0
 1 46
42 hsa-miR-210-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.546E-3 3.564E-2
2.353E-1
1.000E0
 1 47
43 hsa-miR-3141:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-3 3.564E-2
2.353E-1
1.000E0
 1 50
44 hsa-miR-6759-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.932E-3 3.564E-2
2.353E-1
1.000E0
 1 51
45 hsa-miR-609:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.028E-3 3.564E-2
2.353E-1
1.000E0
 1 52
46 hsa-miR-5681b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.564E-2
2.353E-1
1.000E0
 1 53
47 hsa-miR-3972:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.564E-2
2.353E-1
1.000E0
 1 55
48 hsa-miR-767-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.564E-2
2.353E-1
1.000E0
 1 55
49 hsa-miR-491-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.564E-2
2.353E-1
1.000E0
 1 58
50 hsa-miR-1202:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.564E-2
2.353E-1
1.000E0
 1 58
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 2364 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID009547945 DB08184 Stitch 9.842E-16 2.327E-12 1.942E-11 2.327E-12 7 167
2 CID000121875 trapoxin Stitch 1.302E-9 1.539E-6 1.285E-5 3.079E-6 4 58
3 CID000000340 3-methylcatechol Stitch 1.104E-8 8.301E-6 6.928E-5 2.610E-5 4 98
4 CID006368594 AC1OC6D1 Stitch 1.405E-8 8.301E-6 6.928E-5 3.320E-5 4 104
5 CID006098948 ISO-1 cpd Stitch 5.986E-7 2.830E-4 2.362E-3 1.415E-3 3 60
6 CID000159323 6-methylenetestosterone acetate Stitch 1.207E-6 4.755E-4 3.968E-3 2.853E-3 2 6
7 CID005474719 AC1NV99J Stitch 9.641E-6 3.256E-3 2.717E-2 2.279E-2 2 16
8 CID000002992 AC1L1EXH Stitch 1.229E-5 3.273E-3 2.731E-2 2.905E-2 2 18
9 CID000019103 NSC3852 Stitch 1.526E-5 3.273E-3 2.731E-2 3.607E-2 2 20
10 2869 DN Chloroquine diphosphate [50-63-5]; Down 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.935E-5 3.273E-3 2.731E-2 4.574E-2 3 190
11 1859 DN Sulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.091E-5 3.273E-3 2.731E-2 4.944E-2 3 195
12 1823 DN Amitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.091E-5 3.273E-3 2.731E-2 4.944E-2 3 195
13 4206 DN Pepstatin A [26305-03-3]; Down 200; 5.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.123E-5 3.273E-3 2.731E-2
5.020E-2
 3 196
14 2766 UP Pseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.156E-5 3.273E-3 2.731E-2
5.097E-2
 3 197
15 2392 DN Dyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.189E-5 3.273E-3 2.731E-2
5.174E-2
 3 198
16 CID000002706 AC1L1EA5 Stitch 2.215E-5 3.273E-3 2.731E-2
5.236E-2
 2 24
17 ctd:C013598 methoxyacetic acid CTD 5.643E-5 7.847E-3
6.548E-2
1.334E-1
 3 272
18 CID000137438 AC1L3ALC Stitch 1.060E-4 1.392E-2
1.162E-1
2.505E-1
 2 52
19 ctd:D006997 Hypochlorous Acid CTD 1.606E-4 1.719E-2
1.435E-1
3.796E-1
 3 387
20 CID000000597 cytosine Stitch 2.362E-4 1.719E-2
1.435E-1
5.583E-1
 3 441
21 CID000005532 Trapoxin B Stitch 2.453E-4 1.719E-2
1.435E-1
5.798E-1
 2 79
22 CID000001176 lotion Stitch 2.773E-4 1.719E-2
1.435E-1
6.556E-1
 2 84
23 CID010174526 2-[1-(benzyloxycarbonylamino)hexyl-hydroxy-phosphoryl]oxy-2-(3-guanidinophenyl)acetic acid Stitch 2.907E-4 1.719E-2
1.435E-1
6.871E-1
 2 86
24 CID006445533 LAQ824 Stitch 3.326E-4 1.719E-2
1.435E-1
7.863E-1
 2 92
25 CID000007628 borate Stitch 3.773E-4 1.719E-2
1.435E-1
8.920E-1
 2 98
26 CID006918837 LBH589 Stitch 4.665E-4 1.719E-2
1.435E-1
1.000E0
 2 109
27 CID000467801 Apicidin Stitch 5.013E-4 1.719E-2
1.435E-1
1.000E0
 2 113
28 CID000029051 NSC24559 Stitch 5.839E-4 1.719E-2
1.435E-1
1.000E0
 2 122
29 CID006914639 AC1OCADI Stitch 6.626E-4 1.719E-2
1.435E-1
1.000E0
 2 130
30 CID000004261 MS-275 Stitch 8.688E-4 1.719E-2
1.435E-1
1.000E0
 2 149
31 4237 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.168E-3 1.719E-2
1.435E-1
1.000E0
 2 173
32 ctd:C572247 thiamet G CTD 1.225E-3 1.719E-2
1.435E-1
1.000E0
 1 4
33 ctd:D015762 2-Chloroadenosine CTD 1.225E-3 1.719E-2
1.435E-1
1.000E0
 1 4
34 869 DN wortmannin; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.392E-3 1.719E-2
1.435E-1
1.000E0
 2 189
35 6770 UP Oxybutynin chloride [1508-65-2]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.392E-3 1.719E-2
1.435E-1
1.000E0
 2 189
36 CID000005350 sulforaphane Stitch 1.392E-3 1.719E-2
1.435E-1
1.000E0
 2 189
37 4322 DN Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.406E-3 1.719E-2
1.435E-1
1.000E0
 2 190
38 5084 DN Resveratrol [501-36-0]; Down 200; 17.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.406E-3 1.719E-2
1.435E-1
1.000E0
 2 190
39 4247 DN Piperine [94-62-2]; Down 200; 14uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.421E-3 1.719E-2
1.435E-1
1.000E0
 2 191
40 7438 DN Isotretinoin [4759-48-2]; Down 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.421E-3 1.719E-2
1.435E-1
1.000E0
 2 191
41 1008 DN geldanamycin; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.421E-3 1.719E-2
1.435E-1
1.000E0
 2 191
42 6746 DN Calciferol [50-14-6]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.421E-3 1.719E-2
1.435E-1
1.000E0
 2 191
43 7078 UP Alsterpaullone; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.421E-3 1.719E-2
1.435E-1
1.000E0
 2 191
44 3262 UP Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
45 1988 UP Captopril [62571-86-2]; Up 200; 17.2uM; HL60; HG-U133A Broad Institute CMAP Up 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
46 1464 DN Cimetidine [51481-61-9]; Down 200; 15.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
47 2142 DN Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
48 544 UP radicicol; Up 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP Up 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
49 6422 DN STOCK1N-35215; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
50 6512 UP Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.451E-3 1.719E-2
1.435E-1
1.000E0
 2 193
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 59 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0549175 Fibromatosis colli DisGeNET BeFree 1.295E-3 3.396E-2
1.584E-1
7.643E-2
 1 3
2 C1843256 IRAK4 Deficiency DisGeNET Curated 1.727E-3 3.396E-2
1.584E-1
1.019E-1
 1 4
3 C4024988 Intestinal carcinoid DisGeNET Curated 1.727E-3 3.396E-2
1.584E-1
1.019E-1
 1 4
4 C2936739 Hyper-Immunoglobulin E Syndrome, Autosomal Dominant DisGeNET Curated 2.589E-3 3.819E-2
1.781E-1
1.528E-1
 1 6
5 C0079352 Congenital torticollis DisGeNET Curated 3.882E-3 4.449E-2
2.075E-1
2.290E-1
 1 9
6 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 5.183E-3 4.449E-2
2.075E-1
3.058E-1
 2 262
7 C0042341 Varicocele DisGeNET Curated 6.033E-3 4.449E-2
2.075E-1
3.559E-1
 1 14
8 C0334277 Adenocarcinoma, metastatic DisGeNET BeFree 6.033E-3 4.449E-2
2.075E-1
3.559E-1
 1 14
9 C0272242 Complement deficiency disease DisGeNET Curated 6.892E-3 4.518E-2
2.107E-1
4.066E-1
 1 16
10 C1336905 Endometrial Endometrioid Adenocarcinoma DisGeNET BeFree 8.180E-3 4.654E-2
2.170E-1
4.826E-1
 1 19
11 C0340803 Capillary malformation (disorder) DisGeNET Curated 9.038E-3 4.654E-2
2.170E-1
5.332E-1
 1 21
12 C0024140 Lupus Erythematosus, Subacute Cutaneous DisGeNET BeFree 9.466E-3 4.654E-2
2.170E-1
5.585E-1
 1 22
13 C0003615 Appendicitis DisGeNET Curated 1.032E-2 4.685E-2
2.185E-1
6.091E-1
 1 24
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