Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc41_14, positive side

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1: GO: Molecular Function [Display Chart] 14 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.240E-7 3.101E-6 1.183E-5 3.101E-6 6 357
2 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 4.823E-6 6.028E-5 2.300E-4 1.206E-4 5 365
3 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 3.253E-5 2.711E-4 1.034E-3 8.132E-4 4 259
4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 5.854E-5 3.659E-4 1.396E-3 1.463E-3 3 104
5 GO:0001205 distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific 2.246E-4 1.123E-3 4.286E-3 5.616E-3 2 30
6 GO:0050681 androgen receptor binding 4.215E-4 1.756E-3 6.701E-3 1.054E-2 2 41
7 GO:0046332 SMAD binding 1.481E-3 4.930E-3 1.881E-2 3.702E-2 2 77
8 GO:0031490 chromatin DNA binding 1.801E-3 4.930E-3 1.881E-2 4.502E-2 2 85
9 GO:0008013 beta-catenin binding 1.972E-3 4.930E-3 1.881E-2 4.930E-2 2 89
10 GO:0035258 steroid hormone receptor binding 1.972E-3 4.930E-3 1.881E-2 4.930E-2 2 89
11 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 2.561E-3 5.821E-3 2.221E-2
6.403E-2
 3 379
12 GO:0000987 proximal promoter sequence-specific DNA binding 2.942E-3 6.130E-3 2.339E-2
7.356E-2
 3 398
13 GO:0035257 nuclear hormone receptor binding 6.289E-3 1.209E-2 4.615E-2
1.572E-1
 2 161
14 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 7.970E-3 1.342E-2
5.123E-2
1.993E-1
 2 182
15 GO:0051427 hormone receptor binding 8.055E-3 1.342E-2
5.123E-2
2.014E-1
 2 183
16 GO:0070410 co-SMAD binding 8.968E-3 1.401E-2
5.347E-2
2.242E-1
 1 12
17 GO:1990841 promoter-specific chromatin binding 1.268E-2 1.865E-2
7.117E-2
3.171E-1
 1 17
18 GO:0070412 R-SMAD binding 1.786E-2 2.481E-2
9.467E-2
4.465E-1
 1 24
19 GO:0001221 transcription cofactor binding 2.228E-2 2.785E-2
1.063E-1
5.570E-1
 1 30
20 GO:0043425 bHLH transcription factor binding 2.228E-2 2.785E-2
1.063E-1
5.570E-1
 1 30
21 GO:0043621 protein self-association 4.122E-2 4.907E-2
1.872E-1
1.000E0
 1 56
Show 16 more annotations

2: GO: Biological Process [Display Chart] 14 input genes in category / 779 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045165 cell fate commitment 1.194E-6 9.301E-4 6.730E-3 9.301E-4 5 274
2 GO:0010721 negative regulation of cell development 4.195E-6 1.011E-3 7.319E-3 3.268E-3 5 354
3 GO:0003002 regionalization 5.205E-6 1.011E-3 7.319E-3 4.055E-3 5 370
4 GO:0060562 epithelial tube morphogenesis 5.414E-6 1.011E-3 7.319E-3 4.217E-3 5 373
5 GO:0060428 lung epithelium development 6.492E-6 1.011E-3 7.319E-3 5.057E-3 3 50
6 GO:0007517 muscle organ development 8.081E-6 1.012E-3 7.326E-3 6.295E-3 5 405
7 GO:0035239 tube morphogenesis 9.098E-6 1.012E-3 7.326E-3 7.087E-3 5 415
8 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1.100E-5 1.071E-3 7.749E-3 8.567E-3 2 7
9 GO:0060425 lung morphogenesis 1.505E-5 1.303E-3 9.426E-3 1.172E-2 3 66
10 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 1.956E-5 1.511E-3 1.094E-2 1.524E-2 3 72
11 GO:0007389 pattern specification process 2.134E-5 1.511E-3 1.094E-2 1.662E-2 5 495
12 GO:0048663 neuron fate commitment 2.489E-5 1.616E-3 1.169E-2 1.939E-2 3 78
13 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 2.875E-5 1.720E-3 1.245E-2 2.240E-2 2 11
14 GO:0042593 glucose homeostasis 3.329E-5 1.720E-3 1.245E-2 2.593E-2 4 260
15 GO:0033500 carbohydrate homeostasis 3.329E-5 1.720E-3 1.245E-2 2.593E-2 4 260
16 GO:0060485 mesenchyme development 3.533E-5 1.720E-3 1.245E-2 2.752E-2 4 264
17 GO:0060766 negative regulation of androgen receptor signaling pathway 4.751E-5 2.177E-3 1.575E-2 3.701E-2 2 14
18 GO:0044331 cell-cell adhesion mediated by cadherin 5.480E-5 2.372E-3 1.716E-2 4.269E-2 2 15
19 GO:0048863 stem cell differentiation 6.046E-5 2.479E-3 1.794E-2 4.710E-2 4 303
20 GO:0009953 dorsal/ventral pattern formation 7.742E-5 3.015E-3 2.182E-2
6.031E-2
 3 114
21 GO:0030518 intracellular steroid hormone receptor signaling pathway 1.307E-4 4.850E-3 3.509E-2
1.018E-1
 3 136
22 GO:0060765 regulation of androgen receptor signaling pathway 1.559E-4 5.280E-3 3.821E-2
1.214E-1
 2 25
23 GO:0010719 negative regulation of epithelial to mesenchymal transition 1.559E-4 5.280E-3 3.821E-2
1.214E-1
 2 25
24 GO:0045880 positive regulation of smoothened signaling pathway 1.962E-4 6.367E-3 4.607E-2
1.528E-1
 2 28
25 GO:0021904 dorsal/ventral neural tube patterning 2.106E-4 6.563E-3 4.749E-2
1.641E-1
 2 29
26 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 2.570E-4 7.297E-3
5.280E-2
2.002E-1
 2 32
27 GO:0060487 lung epithelial cell differentiation 2.734E-4 7.297E-3
5.280E-2
2.130E-1
 2 33
28 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 2.734E-4 7.297E-3
5.280E-2
2.130E-1
 2 33
29 GO:0007219 Notch signaling pathway 2.845E-4 7.297E-3
5.280E-2
2.216E-1
 3 177
30 GO:0060479 lung cell differentiation 2.904E-4 7.297E-3
5.280E-2
2.262E-1
 2 34
31 GO:0048665 neuron fate specification 2.904E-4 7.297E-3
5.280E-2
2.262E-1
 2 34
32 GO:0048754 branching morphogenesis of an epithelial tube 3.188E-4 7.539E-3
5.455E-2
2.483E-1
 3 184
33 GO:0060441 epithelial tube branching involved in lung morphogenesis 3.258E-4 7.539E-3
5.455E-2
2.538E-1
 2 36
34 GO:0014031 mesenchymal cell development 3.290E-4 7.539E-3
5.455E-2
2.563E-1
 3 186
35 GO:0043401 steroid hormone mediated signaling pathway 3.449E-4 7.676E-3
5.554E-2
2.686E-1
 3 189
36 GO:0048864 stem cell development 3.612E-4 7.815E-3
5.655E-2
2.813E-1
 3 192
37 GO:0071542 dopaminergic neuron differentiation 3.827E-4 8.058E-3
5.831E-2
2.982E-1
 2 39
38 GO:0048762 mesenchymal cell differentiation 4.070E-4 8.344E-3
6.037E-2
3.171E-1
 3 200
39 GO:0021532 neural tube patterning 5.330E-4 9.296E-3
6.726E-2
4.152E-1
 2 46
40 GO:0055010 ventricular cardiac muscle tissue morphogenesis 5.330E-4 9.296E-3
6.726E-2
4.152E-1
 2 46
41 GO:0030324 lung development 5.448E-4 9.296E-3
6.726E-2
4.244E-1
 3 221
42 GO:0061138 morphogenesis of a branching epithelium 5.448E-4 9.296E-3
6.726E-2
4.244E-1
 3 221
43 GO:2000737 negative regulation of stem cell differentiation 5.564E-4 9.296E-3
6.726E-2
4.335E-1
 2 47
44 GO:0009952 anterior/posterior pattern specification 5.667E-4 9.296E-3
6.726E-2
4.414E-1
 3 224
45 GO:0030323 respiratory tube development 5.741E-4 9.296E-3
6.726E-2
4.472E-1
 3 225
46 GO:0045665 negative regulation of neuron differentiation 5.891E-4 9.296E-3
6.726E-2
4.589E-1
 3 227
47 GO:0009755 hormone-mediated signaling pathway 6.043E-4 9.296E-3
6.726E-2
4.708E-1
 3 229
48 GO:0030520 intracellular estrogen receptor signaling pathway 6.298E-4 9.296E-3
6.726E-2
4.906E-1
 2 50
49 GO:0001763 morphogenesis of a branching structure 6.678E-4 9.296E-3
6.726E-2
5.202E-1
 3 237
50 GO:0003229 ventricular cardiac muscle tissue development 7.344E-4 9.296E-3
6.726E-2
5.721E-1
 2 54
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 14 input genes in category / 8 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0032444 activin responsive factor complex 2.202E-3 1.762E-2 4.788E-2 1.762E-2 1 3

4: Human Phenotype [Display Chart] 6 input genes in category / 278 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 12 input genes in category / 1401 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003934 abnormal pancreas development 2.937E-7 1.547E-4 1.210E-3 4.115E-4 4 53
2 MP:0008019 increased liver tumor incidence 2.978E-7 1.547E-4 1.210E-3 4.172E-4 5 139
3 MP:0010297 increased hepatobiliary system tumor incidence 3.313E-7 1.547E-4 1.210E-3 4.642E-4 5 142
4 MP:0005217 abnormal pancreatic beta cell morphology 4.806E-7 1.683E-4 1.317E-3 6.733E-4 5 153
5 MP:0003564 abnormal insulin secretion 1.107E-6 2.087E-4 1.633E-3 1.551E-3 5 181
6 MP:0009175 abnormal pancreatic beta cell differentiation 1.140E-6 2.087E-4 1.633E-3 1.598E-3 3 19
7 MP:0014195 abnormal endocrine pancreas secretion 1.201E-6 2.087E-4 1.633E-3 1.683E-3 5 184
8 MP:0002725 abnormal vein morphology 1.301E-6 2.087E-4 1.633E-3 1.823E-3 5 187
9 MP:0006031 abnormal pharyngeal pouch morphology 1.341E-6 2.087E-4 1.633E-3 1.878E-3 3 20
10 MP:0002694 abnormal pancreas secretion 1.561E-6 2.186E-4 1.710E-3 2.186E-3 5 194
11 MP:0003562 abnormal pancreatic beta cell physiology 2.149E-6 2.309E-4 1.806E-3 3.011E-3 5 207
12 MP:0002018 increased malignant tumor incidence 2.189E-6 2.309E-4 1.806E-3 3.067E-3 6 393
13 MP:0004502 decreased incidence of tumors by chemical induction 2.289E-6 2.309E-4 1.806E-3 3.206E-3 4 88
14 MP:0010147 abnormal endocrine pancreas physiology 2.307E-6 2.309E-4 1.806E-3 3.233E-3 5 210
15 MP:0013561 abnormal endocrine gland physiology 2.535E-6 2.368E-4 1.852E-3 3.552E-3 6 403
16 MP:0011932 abnormal endocrine pancreas development 3.833E-6 3.356E-4 2.625E-3 5.370E-3 3 28
17 MP:0005215 abnormal pancreatic islet morphology 4.270E-6 3.393E-4 2.654E-3 5.982E-3 5 238
18 MP:0009165 abnormal endocrine pancreas morphology 4.359E-6 3.393E-4 2.654E-3 6.107E-3 5 239
19 MP:0002053 decreased incidence of induced tumors 5.005E-6 3.691E-4 2.887E-3 7.012E-3 4 107
20 MP:0001177 atelectasis 6.672E-6 4.674E-4 3.656E-3 9.347E-3 4 115
21 MP:0009442 increased ovarian teratoma incidence 7.377E-6 4.922E-4 3.850E-3 1.034E-2 2 4
22 MP:0002190 disorganized myocardium 1.062E-5 6.495E-4 5.081E-3 1.487E-2 3 39
23 MP:0008874 decreased physiological sensitivity to xenobiotic 1.066E-5 6.495E-4 5.081E-3 1.494E-2 5 287
24 MP:0005492 exocrine pancreas hypoplasia 1.229E-5 6.886E-4 5.387E-3 1.722E-2 2 5
25 MP:0009169 pancreatic islet hypoplasia 1.229E-5 6.886E-4 5.387E-3 1.722E-2 2 5
26 MP:0001559 hyperglycemia 1.498E-5 8.073E-4 6.315E-3 2.099E-2 4 141
27 MP:0002693 abnormal pancreas physiology 1.677E-5 8.699E-4 6.805E-3 2.349E-2 5 315
28 MP:0011018 pulmonary hyaline membrane formation 1.842E-5 9.217E-4 7.210E-3 2.581E-2 2 6
29 MP:0004247 small pancreas 2.126E-5 1.027E-3 8.035E-3 2.979E-2 3 49
30 MP:0001944 abnormal pancreas morphology 2.791E-5 1.304E-3 1.020E-2 3.911E-2 5 350
31 MP:0009172 small pancreatic islets 3.184E-5 1.439E-3 1.126E-2 4.461E-2 3 56
32 MP:0003339 decreased pancreatic beta cell number 3.359E-5 1.458E-3 1.140E-2 4.706E-2 3 57
33 MP:0012437 increased Harderian gland tumor incidence 3.434E-5 1.458E-3 1.140E-2 4.811E-2 2 8
34 MP:0002048 increased lung adenoma incidence 3.727E-5 1.536E-3 1.201E-2
5.222E-2
 3 59
35 MP:0020190 abnormal lung adenoma incidence 3.921E-5 1.569E-3 1.228E-2
5.493E-2
 3 60
36 MP:0004554 small pharynx 4.412E-5 1.717E-3 1.343E-2
6.182E-2
 2 9
37 MP:0002672 abnormal pharyngeal arch artery morphology 4.541E-5 1.719E-3 1.345E-2
6.362E-2
 3 63
38 MP:0002047 increased hepatic hemangioma incidence 5.512E-5 2.032E-3 1.590E-2
7.722E-2
 2 10
39 MP:0009106 abnormal pancreas size 7.066E-5 2.538E-3 1.986E-2
9.899E-2
 3 73
40 MP:0020578 abnormal pancreatic beta cell number 7.661E-5 2.666E-3 2.085E-2
1.073E-1
 3 75
41 MP:0012176 abnormal head development 7.971E-5 2.666E-3 2.085E-2
1.117E-1
 3 76
42 MP:0002052 decreased tumor incidence 7.992E-5 2.666E-3 2.085E-2
1.120E-1
 4 216
43 MP:0010306 increased hamartoma incidence 9.535E-5 3.107E-3 2.430E-2
1.336E-1
 2 13
44 MP:0005220 abnormal exocrine pancreas morphology 1.000E-4 3.185E-3 2.491E-2
1.401E-1
 3 82
45 MP:0010816 decreased type I pneumocyte number 1.112E-4 3.319E-3 2.596E-2
1.558E-1
 2 14
46 MP:0010993 decreased surfactant secretion 1.112E-4 3.319E-3 2.596E-2
1.558E-1
 2 14
47 MP:0030385 absent facial bone 1.113E-4 3.319E-3 2.596E-2
1.560E-1
 3 85
48 MP:0009111 pancreas hypoplasia 1.282E-4 3.742E-3 2.927E-2
1.796E-1
 2 15
49 MP:0013151 abnormal incidence of induced tumors 1.409E-4 4.030E-3 3.152E-2
1.975E-1
 4 250
50 MP:0009331 absent primitive node 1.464E-4 4.047E-3 3.166E-2
2.051E-1
 2 16
Show 45 more annotations

6: Domain [Display Chart] 14 input genes in category / 27 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR030456 TF fork head CS 2 InterPro 3.202E-38 4.224E-37 1.644E-36 8.644E-37 14 46
2 IPR018122 TF fork head CS 1 InterPro 6.437E-38 4.224E-37 1.644E-36 1.738E-36 14 48
3 PF00250 Forkhead Pfam 1.252E-37 4.224E-37 1.644E-36 3.380E-36 14 50
4 PS00658 FORK HEAD 2 PROSITE 1.252E-37 4.224E-37 1.644E-36 3.380E-36 14 50
5 IPR001766 Fork head dom InterPro 1.252E-37 4.224E-37 1.644E-36 3.380E-36 14 50
6 PS00657 FORK HEAD 1 PROSITE 1.252E-37 4.224E-37 1.644E-36 3.380E-36 14 50
7 PS50039 FORK HEAD 3 PROSITE 1.252E-37 4.224E-37 1.644E-36 3.380E-36 14 50
8 SM00339 FH SMART 1.252E-37 4.224E-37 1.644E-36 3.380E-36 14 50
9 1.10.10.10 - Gene3D 5.473E-28 1.642E-27 6.389E-27 1.478E-26 14 218
10 IPR011991 WHTH DNA-bd dom InterPro 2.616E-27 7.064E-27 2.749E-26 7.064E-26 14 243
11 PF09354 HNF C Pfam 3.322E-10 6.406E-10 2.493E-9 8.969E-9 3 3
12 IPR013638 Fork-head N InterPro 3.322E-10 6.406E-10 2.493E-9 8.969E-9 3 3
13 IPR018533 Forkhead box C InterPro 3.322E-10 6.406E-10 2.493E-9 8.969E-9 3 3
14 PF08430 Forkhead N Pfam 3.322E-10 6.406E-10 2.493E-9 8.969E-9 3 3
15 IPR032067 FOXO-TAD InterPro 1.555E-6 2.624E-6 1.021E-5 4.198E-5 2 3
16 PF16676 FOXO-TAD Pfam 1.555E-6 2.624E-6 1.021E-5 4.198E-5 2 3
17 IPR032354 FOXP-CC InterPro 3.109E-6 4.663E-6 1.815E-5 8.393E-5 2 4
18 PF16159 FOXP-CC Pfam 3.109E-6 4.663E-6 1.815E-5 8.393E-5 2 4
19 SM00240 FHA SMART 1.938E-4 2.755E-4 1.072E-3 5.234E-3 2 28
20 PS50006 FHA DOMAIN PROSITE 2.382E-4 3.062E-4 1.192E-3 6.430E-3 2 31
21 PF00498 FHA Pfam 2.382E-4 3.062E-4 1.192E-3 6.430E-3 2 31
22 IPR000253 FHA dom InterPro 3.220E-4 3.780E-4 1.471E-3 8.693E-3 2 36
23 2.60.200.20 - Gene3D 3.220E-4 3.780E-4 1.471E-3 8.693E-3 2 36
24 IPR008984 SMAD FHA domain InterPro 6.731E-4 7.572E-4 2.947E-3 1.817E-2 2 52
25 PF16675 FOXO KIX bdg Pfam 1.494E-3 1.551E-3 6.037E-3 4.034E-2 1 2
26 IPR032068 FOXO KIX-bd InterPro 1.494E-3 1.551E-3 6.037E-3 4.034E-2 1 2
27 IPR011051 RmlC Cupin InterPro 1.263E-2 1.263E-2 4.916E-2
3.411E-1
 1 17
Show 22 more annotations

7: Pathway [Display Chart] 12 input genes in category / 80 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138065 FOXA transcription factor networks BioSystems: Pathway Interaction Database 6.842E-10 5.473E-8 2.718E-7 5.473E-8 3 3
2 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 6.448E-7 2.579E-5 1.281E-4 5.158E-5 4 77
3 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 1.757E-6 4.685E-5 2.326E-4 1.405E-4 3 26
4 137979 FOXA1 transcription factor network BioSystems: Pathway Interaction Database 8.262E-6 1.418E-4 7.041E-4 6.610E-4 3 43
5 137911 FOXA2 and FOXA3 transcription factor networks BioSystems: Pathway Interaction Database 8.862E-6 1.418E-4 7.041E-4 7.089E-4 3 44
6 1269190 AKT phosphorylates targets in the nucleus BioSystems: REACTOME 3.055E-5 4.073E-4 2.022E-3 2.444E-3 2 9
7 1270343 Signaling by NODAL BioSystems: REACTOME 1.770E-4 1.730E-3 8.591E-3 1.416E-2 2 21
8 1270341 Regulation of gene expression in beta cells BioSystems: REACTOME 1.770E-4 1.730E-3 8.591E-3 1.416E-2 2 21
9 M15258 AKT Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.946E-4 1.730E-3 8.591E-3 1.557E-2 2 22
10 921162 FoxO signaling pathway BioSystems: KEGG 2.390E-4 1.822E-3 9.046E-3 1.912E-2 3 132
11 1268881 Constitutive Signaling by AKT1 E17K in Cancer BioSystems: REACTOME 2.524E-4 1.822E-3 9.046E-3 2.019E-2 2 25
12 83096 Maturity onset diabetes of the young BioSystems: KEGG 2.733E-4 1.822E-3 9.046E-3 2.186E-2 2 26
13 1270337 Regulation of beta-cell development BioSystems: REACTOME 4.423E-4 2.684E-3 1.333E-2 3.538E-2 2 33
14 138020 Class I PI3K signaling events mediated by Akt BioSystems: Pathway Interaction Database 4.697E-4 2.684E-3 1.333E-2 3.757E-2 2 34
15 137972 Signaling events mediated by HDAC Class III BioSystems: Pathway Interaction Database 6.187E-4 3.300E-3 1.638E-2 4.950E-2 2 39
16 138036 FoxO family signaling BioSystems: Pathway Interaction Database 9.373E-4 4.411E-3 2.190E-2
7.498E-2
 2 48
17 P00048 PI3 kinase pathway PantherDB 9.373E-4 4.411E-3 2.190E-2
7.498E-2
 2 48
18 1340713 Longevity regulating pathway - multiple species BioSystems: KEGG 1.560E-3 6.931E-3 3.442E-2
1.248E-1
 2 62
19 1427860 Deubiquitination BioSystems: REACTOME 2.667E-3 1.123E-2
5.577E-2
2.134E-1
 3 303
20 1268879 PI3K/AKT Signaling in Cancer BioSystems: REACTOME 3.254E-3 1.302E-2
6.463E-2
2.603E-1
 2 90
21 1427861 UCH proteinases BioSystems: REACTOME 4.566E-3 1.739E-2
8.637E-2
3.653E-1
 2 107
22 1269188 PIP3 activates AKT signaling BioSystems: REACTOME 6.180E-3 2.157E-2
1.071E-1
4.944E-1
 2 125
23 1269473 PI3K/AKT activation BioSystems: REACTOME 6.471E-3 2.157E-2
1.071E-1
5.177E-1
 2 128
24 1269384 GAB1 signalosome BioSystems: REACTOME 6.471E-3 2.157E-2
1.071E-1
5.177E-1
 2 128
25 1269302 Role of LAT2/NTAL/LAB on calcium mobilization BioSystems: REACTOME 7.381E-3 2.362E-2
1.173E-1
5.905E-1
 2 137
26 1269621 Signaling by Activin BioSystems: REACTOME 1.246E-2 3.835E-2
1.904E-1
9.971E-1
 1 13
27 M13158 The IGF-1 Receptor and Longevity MSigDB C2 BIOCARTA (v6.0) 1.437E-2 4.226E-2
2.098E-1
1.000E0
 1 15
28 1269185 Downstream signaling events of B Cell Receptor (BCR) BioSystems: REACTOME 1.510E-2 4.226E-2
2.098E-1
1.000E0
 2 199
29 M16884 Role of nicotinic acetylcholine receptors in the regulation of apoptosis MSigDB C2 BIOCARTA (v6.0) 1.532E-2 4.226E-2
2.098E-1
1.000E0
 1 16
30 1269804 Polo-like kinase mediated events BioSystems: REACTOME 1.627E-2 4.339E-2
2.154E-1
1.000E0
 1 17
31 M10145 PTEN dependent cell cycle arrest and apoptosis MSigDB C2 BIOCARTA (v6.0) 1.722E-2 4.444E-2
2.207E-1
1.000E0
 1 18
32 1269183 Signaling by the B Cell Receptor (BCR) BioSystems: REACTOME 2.084E-2 4.879E-2
2.423E-1
1.000E0
 2 236
33 1269800 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 2.101E-2 4.879E-2
2.423E-1
1.000E0
 1 22
34 M17294 Ras Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 2.195E-2 4.879E-2
2.423E-1
1.000E0
 1 23
35 1457788 Neurodegenerative Diseases BioSystems: REACTOME 2.195E-2 4.879E-2
2.423E-1
1.000E0
 1 23
36 1457789 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models BioSystems: REACTOME 2.195E-2 4.879E-2
2.423E-1
1.000E0
 1 23
Show 31 more annotations

8: Pubmed [Display Chart] 14 input genes in category / 4193 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16376864 Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain. Pubmed 1.194E-18 5.008E-15 4.466E-14 5.008E-15 6 13
2 9152011 Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Pubmed 2.527E-14 5.298E-11 4.725E-10 1.060E-10 5 18
3 9032290 Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Pubmed 5.645E-14 7.890E-11 7.036E-10 2.367E-10 4 5
4 7689224 Six members of the mouse forkhead gene family are developmentally regulated. Pubmed 1.421E-12 1.490E-9 1.329E-8 5.960E-9 4 9
5 15084259 Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Pubmed 3.721E-12 3.120E-9 2.783E-8 1.560E-8 4 11
6 8248124 Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
7 1672118 Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
8 8034310 The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
9 19415718 Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
10 8187630 Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
11 10899756 The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
12 9119385 Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. Pubmed 3.920E-11 1.370E-8 1.222E-7 1.644E-7 3 3
13 25402684 Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Pubmed 1.568E-10 4.696E-8 4.188E-7 6.574E-7 3 4
14 20880840 FoxOs function synergistically to promote glucose production. Pubmed 1.568E-10 4.696E-8 4.188E-7 6.574E-7 3 4
15 20932939 Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Pubmed 1.794E-10 5.016E-8 4.474E-7 7.524E-7 6 243
16 15737987 A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism. Pubmed 3.919E-10 1.027E-7 9.159E-7 1.643E-6 3 5
17 29056338 Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Pubmed 7.836E-10 1.729E-7 1.542E-6 3.286E-6 3 6
18 8375339 Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Pubmed 7.836E-10 1.729E-7 1.542E-6 3.286E-6 3 6
19 15389796 Expression of Foxa transcription factors in the developing and adult murine prostate. Pubmed 7.836E-10 1.729E-7 1.542E-6 3.286E-6 3 6
20 8306889 The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Pubmed 2.193E-9 4.598E-7 4.101E-6 9.196E-6 3 8
21 10818213 Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals. Pubmed 3.289E-9 6.567E-7 5.857E-6 1.379E-5 3 9
22 11934848 The onecut transcription factor HNF6 is required for normal development of the biliary tract. Pubmed 4.697E-9 8.564E-7 7.637E-6 1.970E-5 3 10
23 11846474 Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants. Pubmed 4.697E-9 8.564E-7 7.637E-6 1.970E-5 3 10
24 7683413 Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Pubmed 6.458E-9 1.128E-6 1.006E-5 2.708E-5 3 11
25 1612587 Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. Pubmed 8.608E-9 1.388E-6 1.238E-5 3.609E-5 3 12
26 19270025 Requirement for Shh and Fox family genes at different stages in sweat gland development. Pubmed 8.608E-9 1.388E-6 1.238E-5 3.609E-5 3 12
27 10866673 Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Pubmed 1.119E-8 1.737E-6 1.550E-5 4.691E-5 3 13
28 10049364 Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Pubmed 3.189E-8 4.775E-6 4.259E-5 1.337E-4 3 18
29 25249461 Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Pubmed 3.786E-8 5.474E-6 4.882E-5 1.587E-4 3 19
30 12471260 Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Pubmed 4.453E-8 6.224E-6 5.551E-5 1.867E-4 3 20
31 21571225 β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4. Pubmed 5.194E-8 7.025E-6 6.265E-5 2.178E-4 3 21
32 18635606 Crucial role of vHNF1 in vertebrate hepatic specification. Pubmed 7.899E-8 7.369E-6 6.572E-5 3.312E-4 3 24
33 9260895 Differential induction of HNF-3 transcription factors during neuronal differentiation. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
34 28938408 Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
35 11884591 Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
36 28466777 The clinicopathological significance of forkhead box P1 and forkhead box O3a in pancreatic ductal adenocarcinomas. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
37 25805136 FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
38 19276163 Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
39 20934750 Expression and localisation of FoxO3 and FoxO4 in human placenta and fetal membranes. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
40 19737569 Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
41 24893771 Investigating protein-protein interactions in live cells using bioluminescence resonance energy transfer. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
42 25211022 Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
43 29180117 The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
44 26283356 Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
45 27224915 FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
46 9108152 The winged-helix transcription factor Trident is expressed in cycling cells. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
47 19436110 Foxa1 and Foxa2 regulate bile duct development in mice. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
48 19907493 Human-specific transcriptional regulation of CNS development genes by FOXP2. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
49 9441747 The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
50 26890743 Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks. Pubmed 1.248E-7 7.369E-6 6.572E-5 5.232E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 14 input genes in category / 772 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:HOXD13 HOXD13 interactions 7.902E-18 4.243E-15 3.066E-14 6.100E-15 8 51
2 int:SATB2 SATB2 interactions 1.099E-17 4.243E-15 3.066E-14 8.486E-15 8 53
3 int:SATB1 SATB1 interactions 3.522E-10 9.063E-8 6.550E-7 2.719E-7 5 52
4 int:ADAR ADAR interactions 1.880E-9 3.629E-7 2.622E-6 1.451E-6 5 72
5 int:UBP1 UBP1 interactions 1.263E-8 1.951E-6 1.410E-5 9.753E-6 4 35
6 int:ZBTB33 ZBTB33 interactions 1.086E-7 1.283E-5 9.272E-5 8.386E-5 4 59
7 int:CUX1 CUX1 interactions 1.163E-7 1.283E-5 9.272E-5 8.981E-5 4 60
8 int:HOXC13 HOXC13 interactions 3.190E-7 3.079E-5 2.225E-4 2.463E-4 3 18
9 int:HOXB13 HOXB13 interactions 4.453E-7 3.820E-5 2.760E-4 3.438E-4 3 20
10 int:VARS VARS interactions 6.013E-7 4.412E-5 3.189E-4 4.642E-4 4 90
11 int:FOXG1 FOXG1 interactions 6.287E-7 4.412E-5 3.189E-4 4.854E-4 4 91
12 int:SMPD4 SMPD4 interactions 1.275E-6 7.996E-5 5.779E-4 9.842E-4 3 28
13 int:RB1 RB1 interactions 1.347E-6 7.996E-5 5.779E-4 1.040E-3 5 267
14 int:SALL1 SALL1 interactions 1.578E-6 8.704E-5 6.290E-4 1.219E-3 3 30
15 int:TLE1 TLE1 interactions 1.724E-6 8.870E-5 6.411E-4 1.331E-3 4 117
16 int:NR2F1 NR2F1 interactions 3.011E-6 1.453E-4 1.050E-3 2.325E-3 3 37
17 int:SMARCA5 SMARCA5 interactions 4.764E-6 2.163E-4 1.564E-3 3.678E-3 4 151
18 int:ALX4 ALX4 interactions 5.116E-6 2.194E-4 1.586E-3 3.949E-3 3 44
19 int:HDAC2 HDAC2 interactions 7.384E-6 3.000E-4 2.168E-3 5.700E-3 5 378
20 int:SMAD3 SMAD3 interactions 7.871E-6 3.038E-4 2.196E-3 6.076E-3 5 383
21 int:HOXB9 HOXB9 interactions 9.011E-6 3.312E-4 2.394E-3 6.956E-3 3 53
22 int:KIAA0513 KIAA0513 interactions 1.217E-5 4.270E-4 3.086E-3 9.394E-3 2 7
23 int:ZBTB39 ZBTB39 interactions 1.622E-5 5.443E-4 3.934E-3 1.252E-2 2 8
24 int:ONECUT1 ONECUT1 interactions 2.084E-5 6.451E-4 4.662E-3 1.609E-2 2 9
25 int:SCRIB SCRIB interactions 2.089E-5 6.451E-4 4.662E-3 1.613E-2 3 70
26 int:AKAP8 AKAP8 interactions 2.469E-5 7.331E-4 5.298E-3 1.906E-2 3 74
27 int:FOXO3 FOXO3 interactions 2.892E-5 8.270E-4 5.976E-3 2.233E-2 3 78
28 int:GSC GSC interactions 3.181E-5 8.771E-4 6.339E-3 2.456E-2 2 11
29 int:TLE3 TLE3 interactions 3.612E-5 9.503E-4 6.867E-3 2.789E-2 3 84
30 int:FOXO6 FOXO6 interactions 3.816E-5 9.503E-4 6.867E-3 2.946E-2 2 12
31 int:UBA7 UBA7 interactions 3.816E-5 9.503E-4 6.867E-3 2.946E-2 2 12
32 int:SMAD4 SMAD4 interactions 4.176E-5 1.007E-3 7.281E-3 3.224E-2 4 262
33 int:DDX39A DDX39A interactions 4.591E-5 1.074E-3 7.761E-3 3.544E-2 3 91
34 int:GATAD2B GATAD2B interactions 4.899E-5 1.112E-3 8.039E-3 3.782E-2 3 93
35 int:TFCP2 TFCP2 interactions 5.556E-5 1.225E-3 8.856E-3 4.289E-2 3 97
36 int:ABHD10 ABHD10 interactions 6.062E-5 1.270E-3 9.175E-3 4.680E-2 2 15
37 int:FOXK1 FOXK1 interactions 6.085E-5 1.270E-3 9.175E-3 4.697E-2 3 100
38 int:RCC1 RCC1 interactions 7.445E-5 1.512E-3 1.093E-2
5.747E-2
 3 107
39 int:TFAP4 TFAP4 interactions 7.867E-5 1.557E-3 1.125E-2
6.073E-2
 3 109
40 int:ZNF428 ZNF428 interactions 8.822E-5 1.703E-3 1.230E-2
6.810E-2
 2 18
41 int:FOXP4 FOXP4 interactions 9.855E-5 1.856E-3 1.341E-2
7.608E-2
 2 19
42 int:ASXL2 ASXL2 interactions 1.095E-4 2.012E-3 1.454E-2
8.450E-2
 2 20
43 int:CHEK2 CHEK2 interactions 1.154E-4 2.072E-3 1.497E-2
8.909E-2
 3 124
44 int:IKZF1 IKZF1 interactions 1.239E-4 2.173E-3 1.571E-2
9.563E-2
 3 127
45 int:NFIX NFIX interactions 1.455E-4 2.497E-3 1.804E-2
1.124E-1
 2 23
46 int:FOXO4 FOXO4 interactions 1.867E-4 3.134E-3 2.265E-2
1.441E-1
 2 26
47 int:BRMS1L BRMS1L interactions 2.016E-4 3.284E-3 2.373E-2
1.556E-1
 2 27
48 int:FOXP2 FOXP2 interactions 2.170E-4 3.284E-3 2.373E-2
1.675E-1
 2 28
49 int:UHRF1BP1 UHRF1BP1 interactions 2.170E-4 3.284E-3 2.373E-2
1.675E-1
 2 28
50 int:ASXL1 ASXL1 interactions 2.170E-4 3.284E-3 2.373E-2
1.675E-1
 2 28
Show 45 more annotations

10: Cytoband [Display Chart] 14 input genes in category / 14 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q12-q13 14q12-q13 8.077E-4 7.908E-3 2.571E-2 1.131E-2 1 2
2 19q13.2-q13.4 19q13.2-q13.4 1.211E-3 7.908E-3 2.571E-2 1.696E-2 1 3
3 20p11 20p11 2.018E-3 7.908E-3 2.571E-2 2.825E-2 1 5
4 17q11-q12 17q11-q12 2.421E-3 7.908E-3 2.571E-2 3.390E-2 1 6
5 14q13 14q13 2.824E-3 7.908E-3 2.571E-2 3.954E-2 1 7
6 3p14.1 3p14.1 1.005E-2 2.171E-2
7.058E-2
1.407E-1
 1 25
7 7q31 7q31 1.085E-2 2.171E-2
7.058E-2
1.519E-1
 1 27
8 16q24.1 16q24.1 1.445E-2 2.433E-2
7.911E-2
2.022E-1
 1 36
9 17q25 17q25 1.564E-2 2.433E-2
7.911E-2
2.190E-1
 1 39
10 7p22.1 7p22.1 1.922E-2 2.547E-2
8.281E-2
2.690E-1
 1 48
11 Xq13.1 Xq13.1 2.001E-2 2.547E-2
8.281E-2
2.802E-1
 1 50
12 12p13 12p13 2.634E-2 3.072E-2
9.990E-2
3.687E-1
 1 66
13 6q21 6q21 4.082E-2 4.396E-2
1.429E-1
5.714E-1
 1 103
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 291 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$HNF3ALPHA Q6 V$HNF3ALPHA Q6 4.207E-5 5.650E-3 3.533E-2 1.224E-2 4 173
2 V$HNF3B 01 V$HNF3B 01 4.808E-5 5.650E-3 3.533E-2 1.399E-2 4 179
3 V$CEBPDELTA Q6 V$CEBPDELTA Q6 5.825E-5 5.650E-3 3.533E-2 1.695E-2 4 188
4 V$HLF 01 V$HLF 01 8.640E-5 6.286E-3 3.930E-2 2.514E-2 4 208
5 AAAYRNCTG UNKNOWN AAAYRNCTG UNKNOWN 4.275E-4 2.488E-2
1.555E-1
1.244E-1
 4 315
6 V$MSX1 01 V$MSX1 01 6.913E-4 2.905E-2
1.816E-1
2.012E-1
 3 149
7 V$FAC1 01 V$FAC1 01 9.972E-4 2.905E-2
1.816E-1
2.902E-1
 3 169
8 V$PAX2 01 V$PAX2 01 9.993E-4 2.905E-2
1.816E-1
2.908E-1
 2 39
9 V$SRF Q5 01 V$SRF Q5 01 1.486E-3 2.905E-2
1.816E-1
4.324E-1
 3 194
10 V$WHN B V$WHN B 1.622E-3 2.905E-2
1.816E-1
4.720E-1
 3 200
11 V$OCT1 04 V$OCT1 04 1.622E-3 2.905E-2
1.816E-1
4.720E-1
 3 200
12 V$ETS1 B V$ETS1 B 1.693E-3 2.905E-2
1.816E-1
4.927E-1
 3 203
13 V$HNF4 Q6 V$HNF4 Q6 1.766E-3 2.905E-2
1.816E-1
5.139E-1
 3 206
14 V$GATA6 01 V$GATA6 01 1.766E-3 2.905E-2
1.816E-1
5.139E-1
 3 206
15 V$TAL1BETAITF2 01 V$TAL1BETAITF2 01 1.791E-3 2.905E-2
1.816E-1
5.211E-1
 3 207
16 V$AREB6 04 V$AREB6 04 1.816E-3 2.905E-2
1.816E-1
5.283E-1
 3 208
17 V$FOXM1 01 V$FOXM1 01 1.816E-3 2.905E-2
1.816E-1
5.283E-1
 3 208
18 V$LMO2COM 02 V$LMO2COM 02 1.866E-3 2.905E-2
1.816E-1
5.430E-1
 3 210
19 V$CDC5 01 V$CDC5 01 1.970E-3 2.905E-2
1.816E-1
5.732E-1
 3 214
20 V$NFAT Q4 01 V$NFAT Q4 01 1.996E-3 2.905E-2
1.816E-1
5.809E-1
 3 215
21 V$OCT Q6 V$OCT Q6 2.132E-3 2.931E-2
1.833E-1
6.204E-1
 3 220
22 V$OCT1 Q5 01 V$OCT1 Q5 01 2.216E-3 2.931E-2
1.833E-1
6.449E-1
 3 223
23 V$LXR DR4 Q3 V$LXR DR4 Q3 3.556E-3 4.500E-2
2.813E-1
1.000E0
 2 74
Show 18 more annotations

12: Gene Family [Display Chart] 14 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 508 Forkhead boxes genenames.org 1.577E-38 3.154E-38 4.731E-38 3.154E-38 14 43
2 775 Myb/SANT domain containing|Trinucleotide repeat containing genenames.org 1.907E-2 1.907E-2 2.861E-2 3.815E-2 1 25

13: Coexpression [Display Chart] 14 input genes in category / 1271 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M1919 Genes up-regulated in MEF cells (embryonic fibroblast) with double knockout of the translation repressors 4EBP1 [GeneID=1978] and 4EBP2 [GeneID=1979]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.498E-6 1.904E-3 1.471E-2 1.904E-3 5 356
2 M14079 Breast cancer compendium: 100 transcription regulators showing most correlated expression with the 9 'embryonic stem cell' transcription factors that are preferentially and coordinately overexpressed in the high-grade, ER-negative breast cancer tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.755E-5 1.595E-2
1.232E-1
 3.501E-2 3 100
3 18689800-TableS6 Human EmbryonicStemCell Thomas08 113genes GeneSigDB 3.764E-5 1.595E-2
1.232E-1
 4.784E-2 3 111
4 17009876-tableS3b Mouse StemCell Ramos06 211genes GeneSigDB 1.117E-4 3.549E-2
2.742E-1
1.420E-1
 3 160
5 M7999 Selected gradually up-regulated genes whose expression profile follows that of HEMGN [GeneID=55363] in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.565E-4 3.690E-2
2.851E-1
1.989E-1
 2 31
6 M2682 Genes up-regulated in myometrial cells over-expressing a shortened splice form of ATF2 [Gene ID=1386] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.944E-4 3.690E-2
2.851E-1
2.471E-1
 3 193
7 M3435 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes stimulated with anti-Valpha2 antibodies versus CD4 [GeneID=920] CD8 thymocytes stimulated with anti-beta5 antibodies. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 3.690E-2
2.851E-1
2.744E-1
 3 200
8 M10480 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes down-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.487E-4 3.690E-2
2.851E-1
3.161E-1
 2 39
9 15572690-SuppTable5b Mouse Leukemia Walter04 62genes b GeneSigDB 2.887E-4 3.690E-2
2.851E-1
3.670E-1
 2 42
10 M1694 Genes from the brain cancer stem (cancer stem cell, CSC) signature. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.170E-4 3.690E-2
2.851E-1
4.029E-1
 2 44
11 11559565-Table2 Human Brain Rickman01 50genes GeneSigDB 3.619E-4 3.690E-2
2.851E-1
4.599E-1
 2 47
12 15572690-SuppTable5a Mouse Leukemia Walter04 62genes a GeneSigDB 3.775E-4 3.690E-2
2.851E-1
4.798E-1
 2 48
13 15548366-Table2 Mouse Bladder Yao04 53genes GeneSigDB 3.775E-4 3.690E-2
2.851E-1
4.798E-1
 2 48
Show 8 more annotations

14: Coexpression Atlas [Display Chart] 14 input genes in category / 1324 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 6.020E-6 4.785E-3 3.716E-2 7.971E-3 3 57
2 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgM Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgM Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 7.767E-6 4.785E-3 3.716E-2 1.028E-2 3 62
3 gudmap developingLowerUrinaryTract e14.5 urethra 100 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.083E-5 4.785E-3 3.716E-2 2.757E-2 3 86
4 ratio EB-blastocyst vs EB-cbCD34 1000 K2 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 2.979E-5 4.785E-3 3.716E-2 3.944E-2 4 296
5 PCBC MESO-5 100 Progenitor-Cell-Biology-Consortium induced-Mesoderm top-relative-expression-ranked 100 PCBC 3.176E-5 4.785E-3 3.716E-2 4.205E-2 3 99
6 PCBC MESO-5 fibroblast 100 Progenitor-Cell-Biology-Consortium induced-Mesoderm from inducedPluripotentialStemCells derived from from fibroblast top-relative-expression-ranked 100 PCBC 3.176E-5 4.785E-3 3.716E-2 4.205E-2 3 99
7 PCBC DE 100 Progenitor-Cell-Biology-Consortium induced-DefinitiveEndoderm top-relative-expression-ranked 100 PCBC 3.273E-5 4.785E-3 3.716E-2 4.334E-2 3 100
8 PCBC DE fibroblast 100 Progenitor-Cell-Biology-Consortium inducedDefinitiveEndoderm fromFibroblast-derived-iPSC top-relative-expression-ranked 100 PCBC 3.273E-5 4.785E-3 3.716E-2 4.334E-2 3 100
9 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Top 40 GSE76381_iPSMoleculeCountsPMLog2 3.372E-5 4.785E-3 3.716E-2 4.465E-2 3 101
10 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.614E-5 4.785E-3 3.716E-2 4.785E-2 4 311
11 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgM Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgM Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.829E-5 5.813E-3 4.514E-2
6.394E-2
 4 335
12 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Subtype hRgl1 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Subtype hRgl1 Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 5.415E-5 5.975E-3 4.640E-2
7.170E-2
 4 345
13 gudmap developingLowerUrinaryTract e14.5 urethra 100 k2 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 9.590E-5 8.586E-3
6.668E-2
1.270E-1
 2 23
14 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 1.031E-4 8.586E-3
6.668E-2
1.366E-1
 3 147
15 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Top 40 GSE76381_iPSMoleculeCountsPMLog2 1.031E-4 8.586E-3
6.668E-2
1.366E-1
 3 147
16 gudmap developingLowerUrinaryTract e14.5 urethra 500 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.038E-4 8.586E-3
6.668E-2
1.374E-1
 4 408
17 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.259E-4 9.612E-3
7.465E-2
1.667E-1
 4 429
18 gudmap developingKidney e15.5 Peripheral blastema 200 k1 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.328E-4 9.612E-3
7.465E-2
1.759E-1
 2 27
19 Lungmap Mouse Lung E16.5 Epithelial Lungmap Mouse Lung E16.5 Epithelial Lungmap CCHMC 1.438E-4 9.612E-3
7.465E-2
1.903E-1
 4 444
20 gudmap developingLowerUrinaryTract e14.5 urethra 200 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.452E-4 9.612E-3
7.465E-2
1.922E-1
 3 165
21 PCBC ratio EB-blastocyst vs EB-cbCD34 500 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 PCBC 2.034E-4 1.244E-2
9.664E-2
2.693E-1
 4 486
22 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.068E-4 1.244E-2
9.664E-2
2.738E-1
 3 186
23 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.245E-4 1.259E-2
9.775E-2
2.973E-1
 2 35
24 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.377E-4 1.259E-2
9.775E-2
3.147E-1
 2 36
25 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 2.377E-4 1.259E-2
9.775E-2
3.147E-1
 2 36
26 gudmap developingLowerUrinaryTract e14.5 urethra 200 k4 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.792E-4 1.422E-2
1.104E-1
3.697E-1
 2 39
27 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 500 k5 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.237E-4 2.077E-2
1.613E-1
5.609E-1
 2 48
28 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k3 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.619E-4 3.011E-2
2.339E-1
8.763E-1
 2 60
29 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k1 500 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.840E-4 3.011E-2
2.339E-1
9.057E-1
 2 61
30 gudmap developingGonad e11.5 testes k4 1000 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.066E-4 3.011E-2
2.339E-1
9.355E-1
 2 62
31 gudmap developingGonad e11.5 testes and mesonephros k1 1000 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.295E-4 3.011E-2
2.339E-1
9.658E-1
 2 63
32 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hDA Subtype hDA1 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hDA Subtype hDA1 Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 7.764E-4 3.011E-2
2.339E-1
1.000E0
 2 65
33 ratio EB-blastocyst vs EB-cbCD34 500 K3 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 k-means-cluster#3 PCBC 8.246E-4 3.011E-2
2.339E-1
1.000E0
 2 67
34 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbML1 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbML1 Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 8.246E-4 3.011E-2
2.339E-1
1.000E0
 2 67
35 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPM Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPM Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 8.493E-4 3.011E-2
2.339E-1
1.000E0
 2 68
36 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgBP Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgBP Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 8.744E-4 3.011E-2
2.339E-1
1.000E0
 2 69
37 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 8.744E-4 3.011E-2
2.339E-1
1.000E0
 2 69
38 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAc Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAc Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 9.255E-4 3.011E-2
2.339E-1
1.000E0
 2 71
39 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN1 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN1 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 9.255E-4 3.011E-2
2.339E-1
1.000E0
 2 71
40 gudmap kidney single cell e11.5 MetanephMesench Scamp k2 500 kidney single cell e11.5 MetanephMesench StemCellamp k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.516E-4 3.011E-2
2.339E-1
1.000E0
 2 72
41 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Subtype iProg2 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Subtype iProg2 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 9.780E-4 3.011E-2
2.339E-1
1.000E0
 2 73
42 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 100 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 9.780E-4 3.011E-2
2.339E-1
1.000E0
 2 73
43 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Subtype iNb2 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Subtype iNb2 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 9.780E-4 3.011E-2
2.339E-1
1.000E0
 2 73
44 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAb Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAb Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 1.087E-3 3.156E-2
2.451E-1
1.000E0
 2 77
45 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgBP Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgBP Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.092E-3 3.156E-2
2.451E-1
1.000E0
 3 329
46 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPM Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPM Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.121E-3 3.156E-2
2.451E-1
1.000E0
 3 332
47 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 1000 k5 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.144E-3 3.156E-2
2.451E-1
1.000E0
 2 79
48 gudmap developingLowerUrinaryTract e14.5 urethra 500 k1 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.144E-3 3.156E-2
2.451E-1
1.000E0
 2 79
49 Facebase ST1 e8.5 NeuroEpith FloorPlate 100 e8.5 NeuroEpith FloorPlate top-relative-expression-ranked 100 FaceBase_ST1 1.232E-3 3.329E-2
2.585E-1
1.000E0
 2 82
50 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Colon Adenocarcinoma/1/3 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Colon Adenocarcinoma/1/3 TCGA-Colorectal 1.282E-3 3.396E-2
2.637E-1
1.000E0
 1 2
Show 45 more annotations

15: Computational [Display Chart] 10 input genes in category / 99 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 14 input genes in category / 845 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-122-5p:TargetScan hsa-miR-122-5p TargetScan 2.708E-8 2.288E-5 1.674E-4 2.288E-5 4 167
2 hsa-miR-217:TargetScan hsa-miR-217 TargetScan 3.790E-7 1.219E-4 8.922E-4 3.203E-4 4 323
3 hsa-miR-132-3p:TargetScan hsa-miR-132-3p TargetScan 5.772E-7 1.219E-4 8.922E-4 4.877E-4 4 359
4 hsa-miR-212-3p:TargetScan hsa-miR-212-3p TargetScan 5.772E-7 1.219E-4 8.922E-4 4.877E-4 4 359
5 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 1.936E-6 2.726E-4 1.995E-3 1.636E-3 4 487
6 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 1.936E-6 2.726E-4 1.995E-3 1.636E-3 4 487
7 ATGTTAA,MIR-302C:MSigDB ATGTTAA,MIR-302C:MSigDB MSigDB 1.159E-5 1.400E-3 1.024E-2 9.797E-3 3 232
8 hsa-miR-23a-3p:Functional MTI Functional MTI miRTarbase 1.432E-5 1.512E-3 1.107E-2 1.210E-2 3 249
9 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 1.705E-5 1.601E-3 1.171E-2 1.441E-2 3 264
10 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 2.097E-5 1.628E-3 1.191E-2 1.772E-2 3 283
11 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 2.119E-5 1.628E-3 1.191E-2 1.791E-2 3 284
12 hsa-miR-499a-5p:TargetScan hsa-miR-499a-5p TargetScan 2.857E-5 2.012E-3 1.472E-2 2.414E-2 3 314
13 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 3.557E-5 2.147E-3 1.571E-2 3.005E-2 3 338
14 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 3.557E-5 2.147E-3 1.571E-2 3.005E-2 3 338
15 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 5.315E-5 2.922E-3 2.138E-2 4.491E-2 3 387
16 hsa-miR-555:PITA hsa-miR-555:PITA TOP PITA 5.532E-5 2.922E-3 2.138E-2 4.675E-2 2 57
17 hsa-miR-553:mirSVR highEffct hsa-miR-553:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.905E-5 2.935E-3 2.148E-2 4.989E-2 3 401
18 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 7.210E-5 3.339E-3 2.443E-2
6.093E-2
 3 429
19 hsa-miR-1273h-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.121E-5 3.339E-3 2.443E-2
6.862E-2
 2 69
20 hsa-miR-4504:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.359E-5 3.339E-3 2.443E-2
7.063E-2
 2 70
21 hsa-miR-218-2-3p:Functional MTI Functional MTI miRTarbase 8.600E-5 3.339E-3 2.443E-2
7.267E-2
 2 71
22 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 8.692E-5 3.339E-3 2.443E-2
7.345E-2
 3 457
23 hsa-miR-1290:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.600E-5 3.375E-3 2.470E-2
8.112E-2
 2 75
24 hsa-miR-630:Functional MTI Functional MTI miRTarbase 9.858E-5 3.375E-3 2.470E-2
8.330E-2
 2 76
25 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.023E-4 3.375E-3 2.470E-2
8.648E-2
 3 483
26 hsa-miR-7108-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.039E-4 3.375E-3 2.470E-2
8.775E-2
 2 78
27 TTGGGAG,MIR-150:MSigDB TTGGGAG,MIR-150:MSigDB MSigDB 1.093E-4 3.419E-3 2.502E-2
9.232E-2
 2 80
28 hsa-miR-376b-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.205E-4 3.636E-3 2.660E-2
1.018E-1
 2 84
29 hsa-miR-3607-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.674E-4 4.877E-3 3.568E-2
1.414E-1
 2 99
30 hsa-miR-497-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.742E-4 4.907E-3 3.590E-2
1.472E-1
 2 101
31 hsa-miR-122:PITA hsa-miR-122:PITA TOP PITA 1.883E-4 5.132E-3 3.755E-2
1.591E-1
 2 105
32 hsa-miR-4743-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.992E-4 5.259E-3 3.848E-2
1.683E-1
 2 108
33 hsa-miR-370-3p:Functional MTI Functional MTI miRTarbase 2.104E-4 5.322E-3 3.894E-2
1.778E-1
 2 111
34 hsa-miR-376a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 2.142E-4 5.322E-3 3.894E-2
1.810E-1
 2 112
35 hsa-miR-199a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.219E-4 5.356E-3 3.919E-2
1.875E-1
 2 114
36 hsa-miR-4694-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.458E-4 5.769E-3 4.221E-2
2.077E-1
 2 120
37 hsa-miR-6079:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.839E-4 6.382E-3 4.669E-2
2.399E-1
 2 129
38 hsa-miR-625:PITA hsa-miR-625:PITA TOP PITA 2.927E-4 6.382E-3 4.669E-2
2.474E-1
 2 131
39 hsa-miR-1275:PITA hsa-miR-1275:PITA TOP PITA 3.017E-4 6.382E-3 4.669E-2
2.550E-1
 2 133
40 hsa-miR-597:PITA hsa-miR-597:PITA TOP PITA 3.108E-4 6.382E-3 4.669E-2
2.627E-1
 2 135
41 hsa-miR-5681a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.201E-4 6.382E-3 4.669E-2
2.705E-1
 2 137
42 hsa-miR-6835-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.247E-4 6.382E-3 4.669E-2
2.744E-1
 2 138
43 hsa-miR-599:PITA hsa-miR-599:PITA TOP PITA 3.247E-4 6.382E-3 4.669E-2
2.744E-1
 2 138
44 hsa-miR-581:PITA hsa-miR-581:PITA TOP PITA 3.834E-4 6.956E-3
5.090E-2
3.240E-1
 2 150
45 hsa-miR-4795-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.936E-4 6.956E-3
5.090E-2
3.326E-1
 2 152
46 hsa-miR-147:PITA hsa-miR-147:PITA TOP PITA 4.040E-4 6.956E-3
5.090E-2
3.414E-1
 2 154
47 GACTGTT,MIR-212:MSigDB GACTGTT,MIR-212:MSigDB MSigDB 4.040E-4 6.956E-3
5.090E-2
3.414E-1
 2 154
48 hsa-miR-708:PITA hsa-miR-708:PITA TOP PITA 4.040E-4 6.956E-3
5.090E-2
3.414E-1
 2 154
49 GACTGTT,MIR-132:MSigDB GACTGTT,MIR-132:MSigDB MSigDB 4.040E-4 6.956E-3
5.090E-2
3.414E-1
 2 154
50 hsa-miR-28-5p:PITA hsa-miR-28-5p:PITA TOP PITA 4.145E-4 6.956E-3
5.090E-2
3.503E-1
 2 156
Show 45 more annotations

17: Drug [Display Chart] 14 input genes in category / 1995 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000139622 difluoroboron Stitch 1.163E-9 2.320E-6 1.897E-5 2.320E-6 5 84
2 CID000275966 NSC123116 Stitch 3.016E-8 3.008E-5 2.459E-4 6.016E-5 3 11
3 CID000003496 glyphosate Stitch 1.318E-7 8.764E-5 7.165E-4 2.629E-4 5 215
4 ctd:C040109 stanolone benzoate CTD 1.046E-6 5.218E-4 4.266E-3 2.087E-3 2 3
5 CID000124938 AC1L3ZDM Stitch 2.925E-6 1.034E-3 8.457E-3 5.836E-3 3 47
6 CID000000303 sodium cholate Stitch 3.111E-6 1.034E-3 8.457E-3 6.206E-3 5 408
7 CID004620597 Bmps Stitch 9.377E-6 2.673E-3 2.185E-2 1.871E-2 3 69
8 CID005381226 rifampicin Stitch 2.844E-5 7.092E-3
5.798E-2
5.674E-2
 4 306
9 ctd:D017382 Reactive Oxygen Species CTD 3.642E-5 8.074E-3
6.601E-2
7.266E-2
 4 326
10 CID000003488 glibenclamide Stitch 6.751E-5 1.347E-2
1.101E-1
1.347E-1
 4 382
11 CID010086763 (3-amino-3-carboxypropyl)-(2,4-dicarboxybutyl)phosphinate Stitch 8.003E-5 1.451E-2
1.187E-1
1.597E-1
 2 22
12 CID000435143 NSC-364372 Stitch 1.684E-4 2.799E-2
2.288E-1
3.359E-1
 4 484
13 CID000065370 Glat copolymer Stitch 2.052E-4 3.149E-2
2.574E-1
4.094E-1
 2 35
14 ctd:C072581 16-hydroxycleroda-3,13(14)-dien-15,16-olide CTD 2.552E-4 3.636E-2
2.973E-1
5.091E-1
 2 39
15 CID000003134 6-DMAP Stitch 3.105E-4 4.130E-2
3.377E-1
6.195E-1
 2 43
16 CID000448003 AC1L9LHO Stitch 3.712E-4 4.629E-2
3.784E-1
7.406E-1
 2 47
17 CID004568637 AC1ND2OB Stitch 5.113E-4 4.703E-2
3.845E-1
1.000E0
 3 265
18 ctd:C009687 wortmannin CTD 5.226E-4 4.703E-2
3.845E-1
1.000E0
 3 267
19 CID000072052 sprodiamide Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
20 CID000503323 Ro 09-0535 Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
21 CID003005982 Ro 09-0696 Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
22 CID000021723 Teclozan Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
23 CID003035776 Win 33377 Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
24 CID006438866 Ro 09-0410 Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
25 CID000503325 Ro 09-0881 Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
26 CID000405650 Perophora Stitch 6.129E-4 4.703E-2
3.845E-1
1.000E0
 1 1
Show 21 more annotations

18: Disease [Display Chart] 14 input genes in category / 516 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0038476 Supernumerary structure DisGeNET BeFree 2.078E-6 1.072E-3 7.318E-3 1.072E-3 2 3
2 C0023009 Speech and language disorder DisGeNET BeFree 6.921E-6 1.786E-3 1.219E-2 3.571E-3 2 5
3 C0079541 Holoprosencephaly DisGeNET Curated 1.043E-5 1.794E-3 1.224E-2 5.383E-3 3 51
4 C0037822 Speech Disorders DisGeNET Curated 2.956E-5 3.530E-3 2.409E-2 1.525E-2 3 72
5 C0013274 Patent ductus arteriosus DisGeNET Curated 3.420E-5 3.530E-3 2.409E-2 1.765E-2 4 228
6 C1535926 Neurodevelopmental Disorders DisGeNET Curated 1.801E-4 1.515E-2
1.034E-1
9.292E-2
 3 132
7 C0750927 Apraxia, Developmental Verbal DisGeNET Curated 2.056E-4 1.515E-2
1.034E-1
1.061E-1
 2 25
8 C0152101 Hypoplastic Left Heart Syndrome DisGeNET Curated 2.777E-4 1.537E-2
1.049E-1
1.433E-1
 2 29
9 C1510586 Autism Spectrum Disorders DisGeNET Curated 4.175E-4 1.537E-2
1.049E-1
2.154E-1
 4 436
10 C0238461 Anaplastic thyroid carcinoma DisGeNET Curated 4.339E-4 1.537E-2
1.049E-1
2.239E-1
 3 178
11 C0017168 Gastroesophageal reflux disease DisGeNET Curated 4.411E-4 1.537E-2
1.049E-1
2.276E-1
 3 179
12 C0003635 Apraxias DisGeNET Curated 4.787E-4 1.537E-2
1.049E-1
2.470E-1
 2 38
13 C0023015 Language Disorders DisGeNET Curated 5.575E-4 1.537E-2
1.049E-1
2.877E-1
 2 41
14 cv:C0265345 Distichiasis-lymphedema syndrome Clinical Variations 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
15 OMIN:601705 T-CELL IMMUNODEFICIENCY, CONGENITAL ALOPECIA, AND NAIL DYSTROPHY OMIM 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
16 cv:C1866426 T-cell immunodeficiency, congenital alopecia and nail dystrophy Clinical Variations 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
17 OMIN:602081 SPEECH-LANGUAGE DISORDER 1; SPCH1 OMIM 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
18 C2732697 Autoimmune inflammation of skeletal muscle DisGeNET BeFree 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
19 C0751050 Communication Disorders, Developmental DisGeNET BeFree 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
20 C0221348 Hereditary lymphedema and yellow nails DisGeNET Curated 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
21 C4024723 Reduced circulating T-helper cells DisGeNET Curated 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
22 C1866426 T-cell immunodeficiency, congenital alopecia and nail dystrophy DisGeNET Curated 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
23 OMIN:613454 RETT SYNDROME, CONGENITAL VARIANT OMIM 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
24 cv:CN032592 Speech-language disorder 1 Clinical Variations 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
25 C4013764 MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES DisGeNET Curated 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
26 cv:C3150705 Rett syndrome, congenital variant Clinical Variations 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
27 cv:C3150923 Mental retardation with language impairment and autistic features Clinical Variations 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
28 OMIN:153400 LYMPHEDEMA-DISTICHIASIS SYNDROME OMIM 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
29 C0599540 athymia DisGeNET BeFree 8.639E-4 1.537E-2
1.049E-1
4.458E-1
 1 1
30 C0279565 Invasive Lobular Breast Carcinoma DisGeNET BeFree 8.967E-4 1.542E-2
1.052E-1
4.627E-1
 2 52
31 C0598935 Tumor Initiation DisGeNET BeFree 9.738E-4 1.621E-2
1.106E-1
5.025E-1
 3 235
32 C0038271 Stereotyped Behavior DisGeNET Curated 1.272E-3 2.052E-2
1.400E-1
6.566E-1
 2 62
33 C0038273 Stereotypic Movement Disorder DisGeNET Curated 1.355E-3 2.119E-2
1.446E-1
6.993E-1
 2 64
34 C1829460 Tongue thrusting DisGeNET Curated 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
35 C0265992 alopecia congenita DisGeNET BeFree 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
36 C1862177 Diaphyseal medullary stenosis with malignant fibrous histiocytoma DisGeNET Curated 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
37 C3495530 Congenital alopecia X-linked DisGeNET BeFree 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
38 C4025175 Congenital alopecia totalis DisGeNET Curated 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
39 C0265345 Lymphedema distichiasis syndrome DisGeNET Curated 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
40 cv:C0079541 Holoprosencephaly sequence Clinical Variations 1.727E-3 2.228E-2
1.520E-1
8.912E-1
 1 2
41 C0278504 Non-small cell lung cancer stage I DisGeNET BeFree 1.905E-3 2.397E-2
1.636E-1
9.827E-1
 2 76
42 C0340014 Chylothorax, congenital DisGeNET BeFree 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
43 C0423848 Distichiasis DisGeNET Curated 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
44 C0220613 adult soft tissue sarcoma DisGeNET BeFree 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
45 C0006325 Bruxism DisGeNET Curated 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
46 C1262289 dysmetabolic syndrome DisGeNET BeFree 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
47 C3150705 FOXG1 syndrome DisGeNET Curated 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
48 C0009460 Communication impairment DisGeNET BeFree 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
49 C1835228 Lymphedema, predominantly in the lower limbs DisGeNET Curated 2.590E-3 2.727E-2
1.861E-1
1.000E0
 1 3
50 C0920646 Renal ischaemia DisGeNET BeFree 2.835E-3 2.868E-2
1.957E-1
1.000E0
 2 93
Show 45 more annotations