Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc42_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 38 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen 3.231E-10 1.228E-8 5.191E-8 1.228E-8 3 7
2 GO:0004497 monooxygenase activity 3.416E-9 6.491E-8 2.744E-7 1.298E-7 4 97
3 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.710E-8 4.699E-7 1.987E-6 1.410E-6 4 175
4 GO:0004505 phenylalanine 4-monooxygenase activity 1.723E-7 1.637E-6 6.920E-6 6.547E-6 2 3
5 GO:0031406 carboxylic acid binding 2.061E-5 1.355E-4 5.729E-4 7.833E-4 3 240
6 GO:0043177 organic acid binding 2.139E-5 1.355E-4 5.729E-4 8.130E-4 3 243
7 GO:0048037 cofactor binding 3.165E-5 1.718E-4 7.264E-4 1.203E-3 3 277
8 GO:0004155 6,7-dihydropteridine reductase activity 2.679E-4 1.018E-3 4.305E-3 1.018E-2 1 1
9 GO:0004500 dopamine beta-monooxygenase activity 2.679E-4 1.018E-3 4.305E-3 1.018E-2 1 1
10 GO:0004511 tyrosine 3-monooxygenase activity 2.679E-4 1.018E-3 4.305E-3 1.018E-2 1 1
11 GO:0016597 amino acid binding 4.323E-4 1.493E-3 6.314E-3 1.643E-2 2 124
12 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity 5.358E-4 1.697E-3 7.174E-3 2.036E-2 1 2
13 GO:0005506 iron ion binding 7.272E-4 2.126E-3 8.988E-3 2.764E-2 2 161
14 GO:0070404 NADH binding 8.036E-4 2.181E-3 9.222E-3 3.054E-2 1 3
15 GO:0050662 coenzyme binding 1.032E-3 2.545E-3 1.076E-2 3.921E-2 2 192
16 GO:0034617 tetrahydrobiopterin binding 1.071E-3 2.545E-3 1.076E-2 4.071E-2 1 4
17 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen 1.339E-3 2.993E-3 1.266E-2
5.089E-2
 1 5
18 GO:0008199 ferric iron binding 2.677E-3 5.651E-3 2.389E-2
1.017E-1
 1 10
19 GO:0035240 dopamine binding 3.211E-3 6.423E-3 2.716E-2
1.220E-1
 1 12
20 GO:0070402 NADPH binding 4.013E-3 7.625E-3 3.224E-2
1.525E-1
 1 15
21 GO:1901338 catecholamine binding 4.280E-3 7.745E-3 3.275E-2
1.626E-1
 1 16
22 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5.081E-3 8.776E-3 3.711E-2
1.931E-1
 1 19
23 GO:0031418 L-ascorbic acid binding 5.615E-3 9.276E-3 3.922E-2
2.134E-1
 1 21
24 GO:0008198 ferrous iron binding 5.881E-3 9.312E-3 3.937E-2
2.235E-1
 1 22
25 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 8.013E-3 1.218E-2
5.150E-2
3.045E-1
 1 30
26 GO:0050661 NADP binding 1.280E-2 1.870E-2
7.907E-2
4.863E-1
 1 48
27 GO:0019825 oxygen binding 1.359E-2 1.913E-2
8.088E-2
5.165E-1
 1 51
28 GO:0051287 NAD binding 1.518E-2 2.060E-2
8.711E-2
5.769E-1
 1 57
29 GO:0005507 copper ion binding 1.597E-2 2.093E-2
8.850E-2
6.070E-1
 1 60
30 GO:0016836 hydro-lyase activity 1.756E-2 2.224E-2
9.405E-2
6.673E-1
 1 66
31 GO:0070405 ammonium ion binding 2.099E-2 2.524E-2
1.067E-1
7.977E-1
 1 79
32 GO:0048029 monosaccharide binding 2.125E-2 2.524E-2
1.067E-1
8.077E-1
 1 80
33 GO:0016835 carbon-oxygen lyase activity 2.310E-2 2.660E-2
1.124E-1
8.777E-1
 1 87
34 GO:0019842 vitamin binding 2.389E-2 2.670E-2
1.129E-1
9.076E-1
 1 90
35 GO:0009055 electron transfer activity 3.070E-2 3.333E-2
1.409E-1
1.000E0
 1 116
Show 30 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 230 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0009072 aromatic amino acid family metabolic process 2.732E-11 6.283E-9 3.781E-8 6.283E-9 4 30
2 GO:0046146 tetrahydrobiopterin metabolic process 7.801E-10 7.830E-8 4.712E-7 1.794E-7 3 9
3 GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 1.532E-9 7.830E-8 4.712E-7 3.524E-7 3 11
4 GO:0006559 L-phenylalanine catabolic process 1.532E-9 7.830E-8 4.712E-7 3.524E-7 3 11
5 GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 2.043E-9 7.830E-8 4.712E-7 4.698E-7 3 12
6 GO:0006558 L-phenylalanine metabolic process 2.043E-9 7.830E-8 4.712E-7 4.698E-7 3 12
7 GO:0009074 aromatic amino acid family catabolic process 1.058E-8 3.475E-7 2.091E-6 2.433E-6 3 20
8 GO:0009713 catechol-containing compound biosynthetic process 1.643E-8 4.198E-7 2.526E-6 3.778E-6 3 23
9 GO:0042423 catecholamine biosynthetic process 1.643E-8 4.198E-7 2.526E-6 3.778E-6 3 23
10 GO:0042133 neurotransmitter metabolic process 3.764E-8 8.657E-7 5.209E-6 8.657E-6 3 30
11 GO:0042558 pteridine-containing compound metabolic process 7.200E-8 1.505E-6 9.058E-6 1.656E-5 3 37
12 GO:0046189 phenol-containing compound biosynthetic process 1.143E-7 2.191E-6 1.318E-5 2.629E-5 3 43
13 GO:1901605 alpha-amino acid metabolic process 1.495E-7 2.644E-6 1.591E-5 3.438E-5 4 247
14 GO:0006584 catecholamine metabolic process 2.565E-7 3.932E-6 2.366E-5 5.898E-5 3 56
15 GO:0009712 catechol-containing compound metabolic process 2.565E-7 3.932E-6 2.366E-5 5.898E-5 3 56
16 GO:1901565 organonitrogen compound catabolic process 7.147E-7 1.027E-5 6.182E-5 1.644E-4 4 365
17 GO:0006520 cellular amino acid metabolic process 1.052E-6 1.423E-5 8.561E-5 2.419E-4 4 402
18 GO:1901606 alpha-amino acid catabolic process 1.491E-6 1.856E-5 1.117E-4 3.429E-4 3 100
19 GO:0042421 norepinephrine biosynthetic process 1.614E-6 1.856E-5 1.117E-4 3.712E-4 2 8
20 GO:0006729 tetrahydrobiopterin biosynthetic process 1.614E-6 1.856E-5 1.117E-4 3.712E-4 2 8
21 GO:0018958 phenol-containing compound metabolic process 1.778E-6 1.947E-5 1.172E-4 4.089E-4 3 106
22 GO:0019439 aromatic compound catabolic process 2.031E-6 2.123E-5 1.278E-4 4.671E-4 4 474
23 GO:0009063 cellular amino acid catabolic process 2.334E-6 2.334E-5 1.404E-4 5.367E-4 3 116
24 GO:0006570 tyrosine metabolic process 3.169E-6 3.037E-5 1.827E-4 7.288E-4 2 11
25 GO:0042136 neurotransmitter biosynthetic process 5.241E-6 4.822E-5 2.902E-4 1.205E-3 2 14
26 GO:0042415 norepinephrine metabolic process 6.047E-6 5.349E-5 3.219E-4 1.391E-3 2 15
27 GO:0042559 pteridine-containing compound biosynthetic process 8.808E-6 7.503E-5 4.515E-4 2.026E-3 2 18
28 GO:0001505 regulation of neurotransmitter levels 1.471E-5 1.208E-4 7.271E-4 3.384E-3 3 214
29 GO:0046395 carboxylic acid catabolic process 1.874E-5 1.437E-4 8.644E-4 4.310E-3 3 232
30 GO:0016054 organic acid catabolic process 1.874E-5 1.437E-4 8.644E-4 4.310E-3 3 232
31 GO:1901617 organic hydroxy compound biosynthetic process 2.100E-5 1.558E-4 9.375E-4 4.830E-3 3 241
32 GO:0001975 response to amphetamine 3.224E-5 2.317E-4 1.394E-3 7.416E-3 2 34
33 GO:0042417 dopamine metabolic process 3.826E-5 2.667E-4 1.605E-3 8.801E-3 2 37
34 GO:0019098 reproductive behavior 4.480E-5 3.031E-4 1.824E-3 1.030E-2 2 40
35 GO:0006732 coenzyme metabolic process 5.517E-5 3.626E-4 2.182E-3 1.269E-2 3 333
36 GO:0044282 small molecule catabolic process 7.552E-5 4.728E-4 2.845E-3 1.737E-2 3 370
37 GO:0014075 response to amine 7.606E-5 4.728E-4 2.845E-3 1.749E-2 2 52
38 GO:0051186 cofactor metabolic process 1.018E-4 6.159E-4 3.706E-3 2.341E-2 3 409
39 GO:0035690 cellular response to drug 1.718E-4 1.013E-3 6.096E-3 3.951E-2 2 78
40 GO:0006571 tyrosine biosynthetic process 2.685E-4 1.372E-3 8.258E-3
6.175E-2
 1 1
41 GO:0006585 dopamine biosynthetic process from tyrosine 2.685E-4 1.372E-3 8.258E-3
6.175E-2
 1 1
42 GO:0035900 response to isolation stress 2.685E-4 1.372E-3 8.258E-3
6.175E-2
 1 1
43 GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway 2.685E-4 1.372E-3 8.258E-3
6.175E-2
 1 1
44 GO:0046333 octopamine metabolic process 2.685E-4 1.372E-3 8.258E-3
6.175E-2
 1 1
45 GO:0009073 aromatic amino acid family biosynthetic process 2.685E-4 1.372E-3 8.258E-3
6.175E-2
 1 1
46 GO:0007613 memory 4.411E-4 2.205E-3 1.327E-2
1.014E-1
 2 125
47 GO:0051066 dihydrobiopterin metabolic process 5.369E-4 2.423E-3 1.458E-2
1.235E-1
 1 2
48 GO:0052314 phytoalexin metabolic process 5.369E-4 2.423E-3 1.458E-2
1.235E-1
 1 2
49 GO:0042418 epinephrine biosynthetic process 5.369E-4 2.423E-3 1.458E-2
1.235E-1
 1 2
50 GO:0042309 homoiothermy 5.369E-4 2.423E-3 1.458E-2
1.235E-1
 1 2
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034466 chromaffin granule lumen 2.623E-4 4.736E-3 1.860E-2 7.345E-3 1 1
2 GO:0043195 terminal bouton 3.383E-4 4.736E-3 1.860E-2 9.471E-3 2 112
3 GO:0043679 axon terminus 9.290E-4 7.436E-3 2.920E-2 2.601E-2 2 186
4 GO:0044306 neuron projection terminus 1.062E-3 7.436E-3 2.920E-2 2.974E-2 2 199
5 GO:0042584 chromaffin granule membrane 1.573E-3 7.891E-3 3.099E-2 4.405E-2 1 6
6 GO:0042583 chromaffin granule 2.359E-3 7.891E-3 3.099E-2
6.605E-2
 1 9
7 GO:0045009 chitosome 2.359E-3 7.891E-3 3.099E-2
6.605E-2
 1 9
8 GO:0033162 melanosome membrane 2.359E-3 7.891E-3 3.099E-2
6.605E-2
 1 9
9 GO:0033267 axon part 2.536E-3 7.891E-3 3.099E-2
7.102E-2
 2 309
10 GO:0098793 presynapse 3.079E-3 8.622E-3 3.386E-2
8.622E-2
 2 341
11 GO:0030133 transport vesicle 3.692E-3 9.168E-3 3.600E-2
1.034E-1
 2 374
12 GO:0043196 varicosity 3.929E-3 9.168E-3 3.600E-2
1.100E-1
 1 15
13 GO:0005790 smooth endoplasmic reticulum 1.019E-2 2.195E-2
8.619E-2
2.853E-1
 1 39
14 GO:0044304 main axon 1.926E-2 3.853E-2
1.513E-1
5.394E-1
 1 74
15 GO:0034774 secretory granule lumen 2.210E-2 3.922E-2
1.540E-1
6.188E-1
 1 85
16 GO:0030667 secretory granule membrane 2.313E-2 3.922E-2
1.540E-1
6.477E-1
 1 89
17 GO:0060205 cytoplasmic vesicle lumen 2.699E-2 3.922E-2
1.540E-1
7.557E-1
 1 104
18 GO:0042470 melanosome 2.724E-2 3.922E-2
1.540E-1
7.628E-1
 1 105
19 GO:0048770 pigment granule 2.724E-2 3.922E-2
1.540E-1
7.628E-1
 1 105
20 GO:0031983 vesicle lumen 2.801E-2 3.922E-2
1.540E-1
7.844E-1
 1 108
21 GO:0043204 perikaryon 3.670E-2 4.894E-2
1.922E-1
1.000E0
 1 142
22 GO:0008021 synaptic vesicle 4.026E-2 4.963E-2
1.949E-1
1.000E0
 1 156
23 GO:0030658 transport vesicle membrane 4.077E-2 4.963E-2
1.949E-1
1.000E0
 1 158
24 GO:0009898 cytoplasmic side of plasma membrane 4.356E-2 4.963E-2
1.949E-1
1.000E0
 1 169
25 GO:0070382 exocytic vesicle 4.432E-2 4.963E-2
1.949E-1
1.000E0
 1 172
Show 20 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 172 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004923 Hyperphenylalaninemia 1.150E-8 1.731E-6 9.912E-6 1.979E-6 3 6
2 HP:0010893 Abnormality of phenylalanine metabolism 2.012E-8 1.731E-6 9.912E-6 3.461E-6 3 7
3 HP:0004338 Abnormality of aromatic amino acid family metabolism 3.211E-7 1.841E-5 1.054E-4 5.522E-5 3 16
4 HP:0008297 Transient hyperphenylalaninemia 5.413E-6 2.327E-4 1.333E-3 9.310E-4 2 4
5 HP:0001337 Tremor 2.193E-4 7.543E-3 4.320E-2 3.772E-2 4 391
6 HP:0004920 Phenylpyruvic acidemia 1.062E-3 2.030E-2
1.163E-1
1.827E-1
 1 1
7 HP:0100610 Maternal hyperphenylalaninemia 1.062E-3 2.030E-2
1.163E-1
1.827E-1
 1 1
8 HP:0004922 Atypical hyperphenylalaninemia 1.062E-3 2.030E-2
1.163E-1
1.827E-1
 1 1
9 HP:0005982 Reduced phenylalanine hydroxylase activity 1.062E-3 2.030E-2
1.163E-1
1.827E-1
 1 1
10 HP:0002344 Progressive neurologic deterioration 1.942E-3 2.435E-2
1.395E-1
3.340E-1
 2 67
11 HP:0004337 Abnormality of amino acid metabolism 2.005E-3 2.435E-2
1.395E-1
3.448E-1
 3 285
12 HP:0004354 Abnormality of carboxylic acid metabolism 2.109E-3 2.435E-2
1.395E-1
3.628E-1
 3 290
13 HP:0010906 Hyperhistidinemia 2.124E-3 2.435E-2
1.395E-1
3.653E-1
 1 2
14 HP:0012877 Retrograde ejaculation 2.124E-3 2.435E-2
1.395E-1
3.653E-1
 1 2
15 HP:0012875 Abnormal ejaculation 2.124E-3 2.435E-2
1.395E-1
3.653E-1
 1 2
16 HP:0001332 Dystonia 2.808E-3 3.019E-2
1.729E-1
4.830E-1
 3 320
17 HP:0010905 Abnormality of histidine metabolism 3.184E-3 3.221E-2
1.845E-1
5.477E-1
 1 3
18 HP:0003781 Excessive salivation 3.407E-3 3.255E-2
1.865E-1
5.860E-1
 2 89
19 HP:0010904 Abnormality of histidine metabolism 4.244E-3 3.476E-2
1.991E-1
7.299E-1
 1 4
20 HP:0005964 Intermittent hypothermia 4.244E-3 3.476E-2
1.991E-1
7.299E-1
 1 4
21 HP:0003785 Decreased CSF homovanillic acid 4.244E-3 3.476E-2
1.991E-1
7.299E-1
 1 4
22 HP:0001270 Motor delay 4.581E-3 3.581E-2
2.051E-1
7.879E-1
 3 379
23 HP:0000744 Low frustration tolerance 6.360E-3 4.756E-2
2.724E-1
1.000E0
 1 6
24 HP:0002514 Cerebral calcification 6.848E-3 4.908E-2
2.811E-1
1.000E0
 2 127
Show 19 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 205 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001428 adipsia 1.119E-6 1.147E-4 6.769E-4 2.294E-4 2 4
2 MP:0030670 increased circulating phenylalanine level 1.119E-6 1.147E-4 6.769E-4 2.294E-4 2 4
3 MP:0030669 abnormal circulating phenylalanine level 2.796E-6 1.605E-4 9.471E-4 5.732E-4 2 6
4 MP:0030697 increased phenylalanine level 3.914E-6 1.605E-4 9.471E-4 8.023E-4 2 7
5 MP:0003908 decreased stereotypic behavior 3.914E-6 1.605E-4 9.471E-4 8.023E-4 2 7
6 MP:0030696 abnormal phenylalanine level 6.706E-6 2.291E-4 1.353E-3 1.375E-3 2 9
7 MP:0002822 catalepsy 8.381E-6 2.455E-4 1.449E-3 1.718E-3 2 10
8 MP:0011957 decreased compensatory feeding amount 2.232E-5 5.085E-4 3.001E-3 4.576E-3 2 16
9 MP:0001443 poor grooming 2.232E-5 5.085E-4 3.001E-3 4.576E-3 2 16
10 MP:0011956 abnormal compensatory feeding amount 3.903E-5 8.001E-4 4.723E-3 8.001E-3 2 21
11 MP:0002690 akinesia 5.127E-5 9.554E-4 5.640E-3 1.051E-2 2 24
12 MP:0003962 abnormal adrenaline level 9.790E-5 1.546E-3 9.124E-3 2.007E-2 2 33
13 MP:0002204 abnormal neurotransmitter level 9.802E-5 1.546E-3 9.124E-3 2.010E-2 3 225
14 MP:0001409 increased stereotypic behavior 1.914E-4 2.683E-3 1.584E-2 3.924E-2 2 46
15 MP:0005311 abnormal circulating amino acid level 2.064E-4 2.683E-3 1.584E-2 4.231E-2 3 289
16 MP:0009750 impaired behavioral response to addictive substance 2.356E-4 2.683E-3 1.584E-2 4.830E-2 2 51
17 MP:0005156 bradykinesia 2.356E-4 2.683E-3 1.584E-2 4.830E-2 2 51
18 MP:0005498 hyporesponsive to tactile stimuli 2.356E-4 2.683E-3 1.584E-2 4.830E-2 2 51
19 MP:0005643 decreased dopamine level 2.946E-4 3.178E-3 1.876E-2
6.039E-2
 2 57
20 MP:0003964 abnormal noradrenaline level 3.375E-4 3.459E-3 2.042E-2
6.919E-2
 2 61
21 MP:0005332 abnormal amino acid level 3.891E-4 3.798E-3 2.242E-2
7.977E-2
 3 358
22 MP:0002797 increased thigmotaxis 4.704E-4 4.074E-3 2.405E-2
9.643E-2
 2 72
23 MP:0005408 hypopigmentation 4.704E-4 4.074E-3 2.405E-2
9.643E-2
 2 72
24 MP:0001743 absent circulating noradrenaline 4.829E-4 4.074E-3 2.405E-2
9.899E-2
 1 1
25 MP:0005322 abnormal serotonin level 4.969E-4 4.074E-3 2.405E-2
1.019E-1
 2 74
26 MP:0009747 impaired behavioral response to xenobiotic 7.023E-4 5.454E-3 3.219E-2
1.440E-1
 2 88
27 MP:0001462 abnormal avoidance learning behavior 7.183E-4 5.454E-3 3.219E-2
1.472E-1
 2 89
28 MP:0005316 abnormal response to tactile stimuli 9.609E-4 6.396E-3 3.775E-2
1.970E-1
 2 103
29 MP:0012079 abnormal spinal reflex 9.609E-4 6.396E-3 3.775E-2
1.970E-1
 2 103
30 MP:0001742 absent circulating adrenaline 9.655E-4 6.396E-3 3.775E-2
1.979E-1
 1 2
31 MP:0001905 abnormal dopamine level 9.796E-4 6.396E-3 3.775E-2
2.008E-1
 2 104
32 MP:0009748 abnormal behavioral response to addictive substance 9.984E-4 6.396E-3 3.775E-2
2.047E-1
 2 105
33 MP:0001505 hunched posture 1.238E-3 7.690E-3 4.539E-2
2.538E-1
 2 117
34 MP:0005321 abnormal neopterin level 1.448E-3 8.481E-3
5.006E-2
2.968E-1
 1 3
35 MP:0005320 abnormal biopterin level 1.448E-3 8.481E-3
5.006E-2
2.968E-1
 1 3
36 MP:0001440 abnormal grooming behavior 1.503E-3 8.557E-3
5.051E-2
3.080E-1
 2 129
37 MP:0011940 decreased food intake 1.620E-3 8.977E-3
5.299E-2
3.322E-1
 2 134
38 MP:0003674 oxidative stress 1.868E-3 1.008E-2
5.950E-2
3.830E-1
 2 144
39 MP:0010021 heart vascular congestion 1.930E-3 1.015E-2
5.989E-2
3.957E-1
 1 4
40 MP:0001438 aphagia 2.052E-3 1.040E-2
6.137E-2
4.207E-1
 2 151
41 MP:0001422 abnormal drinking behavior 2.079E-3 1.040E-2
6.137E-2
4.263E-1
 2 152
42 MP:0011479 abnormal catecholamine level 2.189E-3 1.068E-2
6.306E-2
4.487E-1
 2 156
43 MP:0003043 hypoalgesia 2.358E-3 1.077E-2
6.356E-2
4.835E-1
 2 162
44 MP:0003186 abnormal redox activity 2.387E-3 1.077E-2
6.356E-2
4.894E-1
 2 163
45 MP:0002316 anoxia 2.412E-3 1.077E-2
6.356E-2
4.945E-1
 1 5
46 MP:0011939 increased food intake 2.416E-3 1.077E-2
6.356E-2
4.953E-1
 2 164
47 MP:0002039 increased neuroblastoma incidence 2.894E-3 1.262E-2
7.452E-2
5.933E-1
 1 6
48 MP:0009078 adrenal gland hyperplasia 3.376E-3 1.442E-2
8.511E-2
6.921E-1
 1 7
49 MP:0001388 abnormal stationary movement 3.968E-3 1.660E-2
9.800E-2
8.135E-1
 2 211
50 MP:0001297 microphthalmia 4.193E-3 1.698E-2
1.002E-1
8.596E-1
 2 217
Show 45 more annotations

6: Domain [Display Chart] 5 input genes in category / 42 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS51410 BH4 AAA HYDROXYL 2 PROSITE 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
2 PS00367 BH4 AAA HYDROXYL 1 PROSITE 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
3 IPR019773 Tyrosine 3-monooxygenase-like InterPro 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
4 PF00351 Biopterin H Pfam 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
5 IPR019774 Aromatic-AA hydroxylase C InterPro 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
6 IPR001273 ArAA hydroxylase InterPro 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
7 IPR018301 ArAA hydroxylase Fe/CU BS InterPro 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
8 1.10.800.10 - Gene3D 3.418E-7 1.795E-6 7.765E-6 1.436E-5 2 4
9 PF12549 TOH N Pfam 2.669E-4 8.622E-4 3.731E-3 1.121E-2 1 1
10 IPR005962 Tyr 3 mOase InterPro 2.669E-4 8.622E-4 3.731E-3 1.121E-2 1 1
11 IPR021164 Tyrosine hydroxylase CS InterPro 2.669E-4 8.622E-4 3.731E-3 1.121E-2 1 1
12 IPR005961 Phe-4-hydroxylase tetra InterPro 2.669E-4 8.622E-4 3.731E-3 1.121E-2 1 1
13 IPR028460 Tbh/DBH InterPro 2.669E-4 8.622E-4 3.731E-3 1.121E-2 1 1
14 IPR014783 Cu2 ascorb mOase CS-2 InterPro 5.337E-4 1.051E-3 4.546E-3 2.242E-2 1 2
15 PF01329 Pterin 4a Pfam 5.337E-4 1.051E-3 4.546E-3 2.242E-2 1 2
16 3.30.1360.20 - Gene3D 5.337E-4 1.051E-3 4.546E-3 2.242E-2 1 2
17 IPR000945 DBH-rel InterPro 5.337E-4 1.051E-3 4.546E-3 2.242E-2 1 2
18 IPR001533 Trans/pterin deHydtase InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
19 IPR024548 Cu2 monoox C InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
20 IPR002912 ACT dom InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
21 2.60.120.230 - Gene3D 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
22 PS51671 ACT PROSITE 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
23 PS00085 CU2 MONOOXYGENASE 2 PROSITE 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
24 2.60.120.310 - Gene3D 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
25 PF01842 ACT Pfam 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
26 PS00084 CU2 MONOOXYGENASE 1 PROSITE 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
27 PF03712 Cu2 monoox C Pfam 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
28 IPR014784 Cu2 ascorb mOase-like C InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
29 IPR020611 Cu2 ascorb mOase CS-1 InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
30 PF01082 Cu2 monooxygen Pfam 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
31 IPR000323 Cu2 ascorb mOase N InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
32 IPR008977 PHM/PNGase F dom InterPro 8.005E-4 1.051E-3 4.546E-3 3.362E-2 1 3
33 PF03351 DOMON Pfam 1.067E-3 1.245E-3 5.387E-3 4.482E-2 1 4
34 SM00664 DoH SMART 1.067E-3 1.245E-3 5.387E-3 4.482E-2 1 4
35 IPR005018 DOMON domain InterPro 1.067E-3 1.245E-3 5.387E-3 4.482E-2 1 4
36 PS50836 DOMON PROSITE 1.067E-3 1.245E-3 5.387E-3 4.482E-2 1 4
37 IPR020904 Sc DH/Rdtase CS InterPro 9.307E-3 1.056E-2 4.571E-2
3.909E-1
 1 35
38 PS00061 ADH SHORT PROSITE 1.407E-2 1.555E-2
6.727E-2
5.908E-1
 1 53
39 PF00106 adh short Pfam 1.459E-2 1.560E-2
6.750E-2
6.129E-1
 1 55
40 IPR002347 SDR fam InterPro 1.486E-2 1.560E-2
6.750E-2
6.240E-1
 1 56
41 3.40.50.720 - Gene3D 4.430E-2 4.533E-2
1.961E-1
1.000E0
 1 169
42 IPR016040 NAD(P)-bd dom InterPro 4.533E-2 4.533E-2
1.961E-1
1.000E0
 1 173
Show 37 more annotations

7: Pathway [Display Chart] 5 input genes in category / 54 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270164 Phenylalanine and tyrosine catabolism BioSystems: REACTOME 5.126E-9 2.768E-7 1.267E-6 2.768E-7 3 11
2 1270158 Metabolism of amino acids and derivatives BioSystems: REACTOME 2.167E-8 5.852E-7 2.678E-6 1.170E-6 5 367
3 142375 phenylalanine degradation/tyrosine biosynthesis BioSystems: BIOCYC 3.871E-7 5.927E-6 2.712E-5 2.090E-5 2 3
4 1309221 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism BioSystems: REACTOME 4.391E-7 5.927E-6 2.712E-5 2.371E-5 3 45
5 1270176 Catecholamine biosynthesis BioSystems: REACTOME 7.740E-7 6.966E-6 3.187E-5 4.180E-5 2 4
6 SMP00012 Catecholamine Biosynthesis SMPDB 7.740E-7 6.966E-6 3.187E-5 4.180E-5 2 4
7 413357 Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline BioSystems: KEGG 1.290E-6 9.950E-6 4.552E-5 6.965E-5 2 5
8 M4557 Biosynthesis of neurotransmitters MSigDB C2 BIOCARTA (v6.0) 1.934E-6 1.306E-5 5.974E-5 1.045E-4 2 6
9 SMP00306 Pindolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
10 SMP00304 Oxprenolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
11 SMP00301 Esmolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
12 SMP00303 Nadolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
13 SMP00297 Alprenolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
14 SMP00366 Nebivolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
15 SMP00307 Propranolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
16 SMP00299 Betaxolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
17 SMP00300 Bisoprolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
18 SMP00305 Penbutolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
19 SMP00298 Atenolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
20 SMP00296 Acebutolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
21 SMP00302 Metoprolol Pathway SMPDB 1.751E-5 4.502E-5 2.060E-4 9.454E-4 2 17
22 1270175 Amine-derived hormones BioSystems: REACTOME 1.969E-5 4.834E-5 2.212E-4 1.063E-3 2 18
23 SMP00368 Labetalol Pathway SMPDB 2.702E-5 6.079E-5 2.781E-4 1.459E-3 2 21
24 SMP00367 Carvedilol Pathway SMPDB 2.702E-5 6.079E-5 2.781E-4 1.459E-3 2 21
25 SMP00006 Tyrosine Metabolism SMPDB 3.549E-5 7.666E-5 3.507E-4 1.916E-3 2 24
26 P00001 Adrenaline and noradrenaline biosynthesis PantherDB 4.857E-5 1.009E-4 4.616E-4 2.623E-3 2 28
27 MAP00350 Tyrosine metabolism MAP00350 Tyrosine metabolism GenMAPP 5.588E-5 1.118E-4 5.114E-4 3.018E-3 2 30
28 82959 Tyrosine metabolism BioSystems: KEGG 7.637E-5 1.473E-4 6.739E-4 4.124E-3 2 35
29 P05912 Dopamine receptor mediated signaling pathway PantherDB 1.697E-4 3.161E-4 1.446E-3 9.166E-3 2 52
30 SMP00206 Phenylketonuria SMPDB 4.016E-4 7.229E-4 3.308E-3 2.169E-2 1 1
31 82965 Phenylalanine, tyrosine and tryptophan biosynthesis BioSystems: KEGG 2.007E-3 3.496E-3 1.599E-2
1.084E-1
 1 5
32 PW:0000075 phenylalanine, tyrosine and tryptophan biosynthetic Pathway Ontology 2.408E-3 4.063E-3 1.859E-2
1.300E-1
 1 6
33 MAP00400 Phenylalanine tyrosine and tryptophan biosynthesis MAP00400 Phenylalanine tyrosine and tryptophan biosynthesis GenMAPP 3.209E-3 5.251E-3 2.403E-2
1.733E-1
 1 8
34 SMP00005 Folate and Pterine Biosynthesis SMPDB 3.610E-3 5.733E-3 2.623E-2
1.949E-1
 1 9
35 SMP00008 Phenylalanine and Tyrosine Metabolism SMPDB 4.411E-3 6.805E-3 3.114E-2
2.382E-1
 1 11
36 MAP00790 Folate biosynthesis MAP00790 Folate biosynthesis GenMAPP 4.811E-3 7.216E-3 3.302E-2
2.598E-1
 1 12
37 83018 Folate biosynthesis BioSystems: KEGG 6.011E-3 8.772E-3 4.014E-2
3.246E-1
 1 15
38 PW:0000052 tyrosine metabolic Pathway Ontology 6.410E-3 8.876E-3 4.061E-2
3.462E-1
 1 16
39 PW:0000018 Parkinson disease Pathway Ontology 6.410E-3 8.876E-3 4.061E-2
3.462E-1
 1 16
40 82960 Phenylalanine metabolism BioSystems: KEGG 6.810E-3 9.193E-3 4.206E-2
3.677E-1
 1 17
41 138078 p38 signaling mediated by MAPKAP kinases BioSystems: Pathway Interaction Database 8.008E-3 1.055E-2 4.826E-2
4.324E-1
 1 20
42 PW:0000140 pathway of folate cycle/metabolism Pathway Ontology 8.407E-3 1.081E-2 4.945E-2
4.540E-1
 1 21
43 P06587 Nicotine pharmacodynamics pathway PantherDB 1.159E-2 1.456E-2
6.662E-2
6.261E-1
 1 29
44 137913 Alpha-synuclein signaling BioSystems: Pathway Interaction Database 1.279E-2 1.569E-2
7.181E-2
6.905E-1
 1 32
45 M2579 Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v6.0) 1.794E-2 2.153E-2
9.853E-2
9.690E-1
 1 45
46 546258 Cocaine addiction BioSystems: KEGG 1.953E-2 2.292E-2
1.049E-1
1.000E0
 1 49
47 138006 ATF-2 transcription factor network BioSystems: Pathway Interaction Database 2.190E-2 2.516E-2
1.151E-1
1.000E0
 1 55
48 547607 Amphetamine addiction BioSystems: KEGG 2.702E-2 3.039E-2
1.391E-1
1.000E0
 1 68
49 814182 Prolactin signaling pathway BioSystems: KEGG 2.780E-2 3.064E-2
1.402E-1
1.000E0
 1 70
50 790012 Biosynthesis of amino acids BioSystems: KEGG 2.976E-2 3.215E-2
1.471E-1
1.000E0
 1 75
Show 45 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 1795 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19674121 Examination of tetrahydrobiopterin pathway genes in autism. Pubmed 7.106E-15 1.276E-11 1.029E-10 1.276E-11 4 9
2 11461190 Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia. Pubmed 4.308E-12 3.866E-9 3.120E-8 7.733E-9 3 4
3 19491146 Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. Pubmed 3.769E-11 2.255E-8 1.820E-7 6.765E-8 3 7
4 19360691 Examination of association to autism of common genetic variationin genes related to dopamine. Pubmed 9.045E-11 4.059E-8 3.276E-7 1.624E-7 3 9
5 20468064 Association study of 182 candidate genes in anorexia nervosa. Pubmed 2.485E-9 8.922E-7 7.200E-6 4.461E-6 4 182
6 15317940 Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
7 16221852 Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
8 16226228 Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
9 8548806 Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
10 9151744 Norepinephrine facilitates the development of the murine sweat response but is not essential. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
11 12604788 Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
12 16723393 Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
13 10518589 Feeding behavior in dopamine-deficient mice. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
14 11430814 Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
15 10027299 Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
16 14684249 The role of dopamine in learning, memory, and performance of a water escape task. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
17 2872999 Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
18 7715704 Noradrenaline is essential for mouse fetal development. Pubmed 1.371E-8 1.367E-6 1.103E-5 2.461E-5 2 2
19 12538862 Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
20 19864633 Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
21 10802666 Dopamine is required for hyperphagia in Lep(ob/ob) mice. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
22 22992525 Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
23 15135070 Different stabilities and denaturation pathways for structurally related aromatic amino acid hydroxylases. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
24 23959937 Restoration of dopamine signaling to the dorsal striatum is sufficient for aspects of active maternal behavior in female mice. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
25 11517332 Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation. Pubmed 4.113E-8 2.953E-6 2.383E-5 7.383E-5 2 3
26 11937441 [Screening of tetrahydrobiopterin deficiency among hyperphenylalaninemic patients]. Pubmed 8.226E-8 4.763E-6 3.844E-5 1.477E-4 2 4
27 10336693 Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform. Pubmed 8.226E-8 4.763E-6 3.844E-5 1.477E-4 2 4
28 9829800 Dopamine-stimulated sexual behavior is testosterone dependent in mice. Pubmed 8.226E-8 4.763E-6 3.844E-5 1.477E-4 2 4
29 19741115 Dopamine is necessary for cue-dependent fear conditioning. Pubmed 8.226E-8 4.763E-6 3.844E-5 1.477E-4 2 4
30 10835639 Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Pubmed 8.226E-8 4.763E-6 3.844E-5 1.477E-4 2 4
31 15374756 A role for dopamine in feeding responses produced by orexigenic agents. Pubmed 8.226E-8 4.763E-6 3.844E-5 1.477E-4 2 4
32 15233745 c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Pubmed 1.371E-7 7.457E-6 6.018E-5 2.461E-4 2 5
33 24565998 Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Pubmed 1.371E-7 7.457E-6 6.018E-5 2.461E-4 2 5
34 22323723 A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. Pubmed 2.056E-7 1.055E-5 8.511E-5 3.691E-4 2 6
35 20875861 Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells. Pubmed 2.056E-7 1.055E-5 8.511E-5 3.691E-4 2 6
36 19545628 In vivo role for CREB signaling in the noradrenergic differentiation of sympathetic neurons. Pubmed 2.879E-7 1.260E-5 1.017E-4 5.167E-4 2 7
37 9435281 Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Pubmed 2.879E-7 1.260E-5 1.017E-4 5.167E-4 2 7
38 22860215 Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain. Pubmed 2.879E-7 1.260E-5 1.017E-4 5.167E-4 2 7
39 16943277 Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation. Pubmed 2.879E-7 1.260E-5 1.017E-4 5.167E-4 2 7
40 17376811 Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Pubmed 2.879E-7 1.260E-5 1.017E-4 5.167E-4 2 7
41 9115735 Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Pubmed 2.879E-7 1.260E-5 1.017E-4 5.167E-4 2 7
42 25093893 Nicotinic receptor Alpha7 expression during mouse adrenal gland development. Pubmed 3.838E-7 1.640E-5 1.324E-4 6.889E-4 2 8
43 18162309 Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. Pubmed 4.934E-7 1.884E-5 1.521E-4 8.857E-4 2 9
44 20702712 The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. Pubmed 4.934E-7 1.884E-5 1.521E-4 8.857E-4 2 9
45 19772578 Two-stage case-control association study of dopamine-related genes and migraine. Pubmed 4.934E-7 1.884E-5 1.521E-4 8.857E-4 2 9
46 7588260 Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Pubmed 4.934E-7 1.884E-5 1.521E-4 8.857E-4 2 9
47 18424435 Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta. Pubmed 4.934E-7 1.884E-5 1.521E-4 8.857E-4 2 9
48 21148012 Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. Pubmed 6.167E-7 2.129E-5 1.718E-4 1.107E-3 2 10
49 7533563 Stage-specific expression of alkaline phosphatase during neural development in the mouse. Pubmed 6.167E-7 2.129E-5 1.718E-4 1.107E-3 2 10
50 22922260 Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression. Pubmed 6.167E-7 2.129E-5 1.718E-4 1.107E-3 2 10
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 121 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PAH PAH interactions 4.326E-11 5.235E-9 2.815E-8 5.235E-9 3 4
2 int:QDPR QDPR interactions 2.234E-5 1.351E-3 7.267E-3 2.703E-3 2 27
3 int:PCBD1 PCBD1 interactions 1.949E-4 7.862E-3 4.228E-2 2.359E-2 2 79
4 int:GPR75-ASB3 GPR75-ASB3 interactions 8.471E-4 1.775E-2
9.543E-2
1.025E-1
 1 3
5 int:RPS24 RPS24 interactions 8.786E-4 1.775E-2
9.543E-2
1.063E-1
 2 168
6 int:ZNF567 ZNF567 interactions 1.129E-3 1.775E-2
9.543E-2
1.367E-1
 1 4
7 int:DIP2C DIP2C interactions 1.412E-3 1.775E-2
9.543E-2
1.708E-1
 1 5
8 int:ZNF714 ZNF714 interactions 1.694E-3 1.775E-2
9.543E-2
2.049E-1
 1 6
9 int:DBH DBH interactions 1.694E-3 1.775E-2
9.543E-2
2.049E-1
 1 6
10 int:TFF3 TFF3 interactions 1.694E-3 1.775E-2
9.543E-2
2.049E-1
 1 6
11 int:HES4 HES4 interactions 1.976E-3 1.775E-2
9.543E-2
2.391E-1
 1 7
12 int:AFMID AFMID interactions 1.976E-3 1.775E-2
9.543E-2
2.391E-1
 1 7
13 int:NCAM2 NCAM2 interactions 1.976E-3 1.775E-2
9.543E-2
2.391E-1
 1 7
14 int:PRADC1 PRADC1 interactions 2.258E-3 1.775E-2
9.543E-2
2.732E-1
 1 8
15 int:SOWAHC SOWAHC interactions 2.540E-3 1.775E-2
9.543E-2
3.073E-1
 1 9
16 int:UAP1L1 UAP1L1 interactions 2.540E-3 1.775E-2
9.543E-2
3.073E-1
 1 9
17 int:ZNF195 ZNF195 interactions 2.822E-3 1.775E-2
9.543E-2
3.414E-1
 1 10
18 int:PAPOLG PAPOLG interactions 2.822E-3 1.775E-2
9.543E-2
3.414E-1
 1 10
19 int:ZBTB34 ZBTB34 interactions 2.822E-3 1.775E-2
9.543E-2
3.414E-1
 1 10
20 int:ZNF23 ZNF23 interactions 3.103E-3 1.775E-2
9.543E-2
3.755E-1
 1 11
21 int:TYSND1 TYSND1 interactions 3.103E-3 1.775E-2
9.543E-2
3.755E-1
 1 11
22 int:ZDHHC13 ZDHHC13 interactions 3.385E-3 1.775E-2
9.543E-2
4.096E-1
 1 12
23 int:PUDP PUDP interactions 3.385E-3 1.775E-2
9.543E-2
4.096E-1
 1 12
24 int:ZNF202 ZNF202 interactions 3.667E-3 1.775E-2
9.543E-2
4.437E-1
 1 13
25 int:KLF13 KLF13 interactions 3.667E-3 1.775E-2
9.543E-2
4.437E-1
 1 13
26 int:MTFR2 MTFR2 interactions 4.793E-3 2.090E-2
1.124E-1
5.799E-1
 1 17
27 int:DNAJC12 DNAJC12 interactions 4.793E-3 2.090E-2
1.124E-1
5.799E-1
 1 17
28 int:ZNF274 ZNF274 interactions 5.074E-3 2.090E-2
1.124E-1
6.140E-1
 1 18
29 int:HSD17B8 HSD17B8 interactions 5.074E-3 2.090E-2
1.124E-1
6.140E-1
 1 18
30 int:ZFP36L1 ZFP36L1 interactions 5.355E-3 2.090E-2
1.124E-1
6.480E-1
 1 19
31 int:RELL1 RELL1 interactions 5.355E-3 2.090E-2
1.124E-1
6.480E-1
 1 19
32 int:TLE6 TLE6 interactions 5.637E-3 2.131E-2
1.146E-1
6.820E-1
 1 20
33 int:ASB15 ASB15 interactions 6.761E-3 2.215E-2
1.191E-1
8.181E-1
 1 24
34 int:TANGO2 TANGO2 interactions 6.761E-3 2.215E-2
1.191E-1
8.181E-1
 1 24
35 int:CACNA1C CACNA1C interactions 7.042E-3 2.215E-2
1.191E-1
8.521E-1
 1 25
36 int:BRPF1 BRPF1 interactions 7.042E-3 2.215E-2
1.191E-1
8.521E-1
 1 25
37 int:MIS18BP1 MIS18BP1 interactions 7.042E-3 2.215E-2
1.191E-1
8.521E-1
 1 25
38 int:TAOK2 TAOK2 interactions 7.042E-3 2.215E-2
1.191E-1
8.521E-1
 1 25
39 int:TH TH interactions 7.323E-3 2.215E-2
1.191E-1
8.860E-1
 1 26
40 int:ZBTB25 ZBTB25 interactions 7.323E-3 2.215E-2
1.191E-1
8.860E-1
 1 26
41 int:SCMH1 SCMH1 interactions 8.445E-3 2.492E-2
1.340E-1
1.000E0
 1 30
42 int:ZNF451 ZNF451 interactions 9.006E-3 2.535E-2
1.363E-1
1.000E0
 1 32
43 int:KDM3B KDM3B interactions 9.567E-3 2.535E-2
1.363E-1
1.000E0
 1 34
44 int:HNF1B HNF1B interactions 9.567E-3 2.535E-2
1.363E-1
1.000E0
 1 34
45 int:PREP PREP interactions 9.567E-3 2.535E-2
1.363E-1
1.000E0
 1 34
46 int:ABAT ABAT interactions 9.847E-3 2.535E-2
1.363E-1
1.000E0
 1 35
47 int:PCBD2 PCBD2 interactions 9.847E-3 2.535E-2
1.363E-1
1.000E0
 1 35
48 int:ANKRD13A ANKRD13A interactions 1.041E-2 2.570E-2
1.382E-1
1.000E0
 1 37
49 int:NUDT18 NUDT18 interactions 1.041E-2 2.570E-2
1.382E-1
1.000E0
 1 37
50 int:CALCOCO1 CALCOCO1 interactions 1.181E-2 2.771E-2
1.490E-1
1.000E0
 1 42
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q22-q24.2 12q22-q24.2 1.443E-4 7.213E-4 1.647E-3 7.213E-4 1 1
2 4p15.31 4p15.31 1.442E-3 3.604E-3 8.230E-3 7.209E-3 1 10
3 10q22 10q22 2.738E-3 4.563E-3 1.042E-2 1.369E-2 1 19
4 9q34 9q34 7.766E-3 9.707E-3 2.217E-2 3.883E-2 1 54
5 11p15.5 11p15.5 1.819E-2 1.819E-2 4.153E-2
9.094E-2
 1 127

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 13 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 1 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 743 Short chain dehydrogenase/reductase superfamily genenames.org 4.177E-3 4.177E-3 4.177E-3 4.177E-3 1 76

13: Coexpression [Display Chart] 5 input genes in category / 388 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14767469-Table3 Human Kidney Bourdeau04 31genes GeneSigDB 1.119E-5 4.340E-3 2.838E-2 4.340E-3 2 25
2 19305503-Table2 Rat Brain Greco09 84genes GeneSigDB 1.143E-4 1.517E-2
9.919E-2
 4.437E-2 2 79
3 M9911 Genes negatively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.173E-4 1.517E-2
9.919E-2
 4.550E-2 2 80
4 M5654 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute E. coli infection. MSigDB C7: Immunologic Signatures (v6.0) 4.924E-4 2.363E-2
1.545E-1
1.911E-1
 2 164
5 M3282 Genes up-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 3 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 6.879E-4 2.363E-2
1.545E-1
2.669E-1
 2 194
6 M5252 Genes up-regulated in comparison of macrophages exposed to L. major versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 7.021E-4 2.363E-2
1.545E-1
2.724E-1
 2 196
7 M3731 Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.363E-2
1.545E-1
2.808E-1
 2 199
8 M3703 Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with LPS (TLR4 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.363E-2
1.545E-1
2.808E-1
 2 199
9 M9632 Genes down-regulated in CD4 [GeneID=920] T helper cells (42h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.363E-2
1.545E-1
2.836E-1
 2 200
10 M3757 Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with CpG DNA (TLR9 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.363E-2
1.545E-1
2.836E-1
 2 200
11 M6395 Genes up-regulated in plasma cells versus memory B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.363E-2
1.545E-1
2.836E-1
 2 200
12 M9535 Genes down-regulated in skin: uninfected versus S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.363E-2
1.545E-1
2.836E-1
 2 200
13 M1286 Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.287E-3 3.592E-2
2.349E-1
4.994E-1
 2 266
14 M1290 Genes involved in serotonin [PubChem=5202] function, orthologs computed from D. melanogaster genes using InsParanoid resource. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 3.592E-2
2.349E-1
5.029E-1
 1 6
15 M1762 Genes up-regulated in EpiSC cells (epiblast stem cells) after treatment with the ALK [GeneID=238] inhibitor SB-431542 [PubChem=4521392]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.512E-3 3.911E-2
2.558E-1
5.866E-1
 1 7
16 16166195-Table2b Mouse Testicular Denolet06 12genes GeneSigDB 2.159E-3 4.950E-2
3.237E-1
8.378E-1
 1 10
17 18959789-Table3 Human Viral Zekri08 11genes BiologicalProcessUpRegulated GeneSigDB 2.375E-3 4.950E-2
3.237E-1
9.215E-1
 1 11
18 19305503-TableS1 Rat Brain Greco09 425genes GeneSigDB 2.699E-3 4.950E-2
3.237E-1
1.000E0
 2 387
19 M12228 Down-regulated genes in hepatocellular carcinoma (HCC) subclass G12, defined by unsupervised clustering MSigDB C2: CGP Curated Gene Sets (v6.0) 3.238E-3 4.950E-2
3.237E-1
1.000E0
 1 15
20 17855657-Table2b Human Breast Abba07 24genes GeneSigDB 3.453E-3 4.950E-2
3.237E-1
1.000E0
 1 16
21 M12393 Selected genes down-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.669E-3 4.950E-2
3.237E-1
1.000E0
 1 17
22 12631704-table1 Human StemCell Qi03 534genes GeneSigDB 4.070E-3 4.950E-2
3.237E-1
1.000E0
 2 477
23 M11814 Genes down-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.100E-3 4.950E-2
3.237E-1
1.000E0
 1 19
24 15843827-TableS12 Human Leukemia Andersson05 23genes GeneSigDB 4.100E-3 4.950E-2
3.237E-1
1.000E0
 1 19
25 17234769-TableS5b Human StemCell West07 29genes GeneSigDB 5.176E-3 4.950E-2
3.237E-1
1.000E0
 1 24
26 M18519 Down-regulated genes in pediatric adrenocortical carcinoma (ACC) compared to the adenoma (ACA) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.176E-3 4.950E-2
3.237E-1
1.000E0
 1 24
27 M9096 Genes up-regulated during transition from G2 (moderately differentiated tumor, infected with HCV) to G3 (poorly differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.037E-3 4.950E-2
3.237E-1
1.000E0
 1 28
28 15791284-Table2 Human Pancreas Fukushima05 20genes Parenchyma GeneSigDB 6.467E-3 4.950E-2
3.237E-1
1.000E0
 1 30
29 M15762 Neuroblastoma markers down-regulated in neuroblastoma cell lines expressing ESWR1-FLI1 [GeneID=2130;2313] fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.467E-3 4.950E-2
3.237E-1
1.000E0
 1 30
30 15546871-Table2 Mouse Liver White05 60genes GeneSigDB 6.897E-3 4.950E-2
3.237E-1
1.000E0
 1 32
31 18691415-Table5b Human Colon Solmi08 36genes GeneSigDB 6.897E-3 4.950E-2
3.237E-1
1.000E0
 1 32
32 M13220 Genes down-regulated in pirmary cultures of epithelial ovarian cancer (EOC): invasive (TOV) vs low malignant potential (LMP) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.541E-3 4.950E-2
3.237E-1
1.000E0
 1 35
33 M10245 Genes up-regulated in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of congenic D.B. Chr 3 (DB, small HSC population) vs parental D2 strain (huge HSC population). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.186E-3 4.950E-2
3.237E-1
1.000E0
 1 38
34 M2003 Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 K27 trimethylation mark (H3K27me3) in embryonic stem cells (ES). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.044E-3 4.950E-2
3.237E-1
1.000E0
 1 42
35 M3471 Genes whose expression peaked at 120 min after stimulation of MCF10A cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.950E-2
3.237E-1
1.000E0
 1 43
36 18395814-Table1b Human StemCell Yang08 49genes GeneSigDB 9.473E-3 4.950E-2
3.237E-1
1.000E0
 1 44
37 M1240 Genes down-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.688E-3 4.950E-2
3.237E-1
1.000E0
 1 45
38 M13059 The v2LDG set: 50 most variable late differentiation genes (LDG) with similar expression patterns in bone marrow plasma cells (BPC) and multiple myeloma (MM) samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.688E-3 4.950E-2
3.237E-1
1.000E0
 1 45
39 M8604 Genes down-regulated in H358 cells (lung cancer) by inducible expression of CEBPA [GeneID=1050] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.902E-3 4.950E-2
3.237E-1
1.000E0
 1 46
40 12393520-Table6 Human Bone Marrow Zhan03 50genes v2LDGs GeneSigDB 1.033E-2 4.950E-2
3.237E-1
1.000E0
 1 48
41 M1702 High-grade amplification (copy number, CN >= 5) detected in primary neuroblastoma samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.076E-2 4.950E-2
3.237E-1
1.000E0
 1 50
42 M8655 'Cancer prone response profile' (CPRP): genes changed in response to bisphenol A [PubChem=6623] in epithelial cell cultures from patients at high risk of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.097E-2 4.950E-2
3.237E-1
1.000E0
 1 51
43 16473350-Table1 Human Brain Jrgensen05 59genes GeneSigDB 1.119E-2 4.950E-2
3.237E-1
1.000E0
 1 52
44 M19948 Genes whose DNA was methylated both in primary tumors and across a panel of cancer cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.204E-2 4.950E-2
3.237E-1
1.000E0
 1 56
45 M500 Genes whose expression is significantly and positively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.204E-2 4.950E-2
3.237E-1
1.000E0
 1 56
46 M3447 Genes whose expression peaked at 60 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.226E-2 4.950E-2
3.237E-1
1.000E0
 1 57
47 M1758 Wnt target genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine that require functional MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.247E-2 4.950E-2
3.237E-1
1.000E0
 1 58
48 11493696-TableS3 Human Kidney Takahashi01 77genes GeneSigDB 1.269E-2 4.950E-2
3.237E-1
1.000E0
 1 59
49 15750623-Table1 Mouse Brain Johansson05 60genes GeneSigDB 1.269E-2 4.950E-2
3.237E-1
1.000E0
 1 59
50 18413728-Table2a Human Brain Molenaar08 69genes GeneSigDB 1.290E-2 4.950E-2
3.237E-1
1.000E0
 1 60
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 571 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k3 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.685E-8 6.008E-6 4.161E-5 9.620E-6 3 27
2 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k4 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.104E-8 6.008E-6 4.161E-5 1.202E-5 3 29
3 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k3 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.752E-7 4.273E-5 2.959E-4 1.571E-4 3 67
4 Kidney10XCellRanger Six2TGC TSC1 E14 NPC NPC Subtype E14-Six2TGC Tsc1-NPCU-C3-KC10 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 NPC NPC Subtype E14-Six2TGC Tsc1-NPCU-C3-KC10 Top 200 Genes 2.993E-7 4.273E-5 2.959E-4 1.709E-4 4 344
5 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k4 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.190E-7 9.353E-5 6.478E-4 4.677E-4 3 96
6 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k2 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.558E-6 2.434E-4 1.686E-3 1.461E-3 3 140
7 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium 4.194E-6 3.275E-4 2.268E-3 2.395E-3 3 165
8 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.588E-6 3.275E-4 2.268E-3 2.620E-3 3 170
9 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/epithelial cell of proximal tubule Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/epithelial cell of proximal tubule Tabula Muris Consortium 6.307E-6 3.895E-4 2.698E-3 3.602E-3 3 189
10 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 6.822E-6 3.895E-4 2.698E-3 3.895E-3 3 194
11 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 200 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.799E-6 4.568E-4 3.163E-3 5.024E-3 2 21
12 BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Noradrenergic Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Noradrenergic Top 200 Genes BrainMap 2.160E-5 1.028E-3 7.118E-3 1.233E-2 3 285
13 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k2 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.757E-5 2.529E-3 1.751E-2 3.287E-2 2 53
14 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.019E-5 2.863E-3 1.983E-2 4.008E-2 3 423
15 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.946E-5 3.003E-3 2.080E-2 4.537E-2 3 441
16 BM Top 100 - substantia nigra BM Top 100 - substantia nigra Body Map 8.414E-5 3.003E-3 2.080E-2 4.804E-2 2 64
17 BM Top 100 - ventral tegmental area BM Top 100 - ventral tegmental area Body Map 9.504E-5 3.192E-3 2.211E-2
5.427E-2
 2 68
18 gudmap kidney single cell adult RenalCortexMixed Scamp 100 kidney single cell adult RenalCortexMixed StemCellamp top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.487E-4 4.717E-3 3.267E-2
8.491E-2
 2 85
19 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k3 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.372E-4 1.014E-2
7.019E-2
1.926E-1
 2 128
20 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney Tabula Muris Consortium 3.640E-4 1.039E-2
7.198E-2
2.079E-1
 2 133
21 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 200 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.505E-4 1.101E-2
7.624E-2
2.572E-1
 2 148
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal VHL RCC U U/Kidney Normal VHL RCC U9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal VHL RCC U U/Kidney Normal VHL RCC U9 Adult, Development, and Cancer types 4.581E-4 1.101E-2
7.624E-2
2.616E-1
 1 2
23 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/SubstantiaNigra BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/SubstantiaNigra BrainMap 4.581E-4 1.101E-2
7.624E-2
2.616E-1
 1 2
24 gudmap kidney single cell adult RenalCortexMixed Scamp k3 200 kidney single cell adult RenalCortexMixed StemCellamp k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.627E-4 1.101E-2
7.624E-2
2.642E-1
 2 150
25 gudmap kidney adult RenalCortexMixed Std 200 kidney adult RenalCortexMixed Std top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.262E-4 1.127E-2
7.806E-2
3.005E-1
 2 160
26 gudmap kidney adult JuxtaGlom Ren1 200 kidney adult JuxtaGlom Ren1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.461E-4 1.127E-2
7.806E-2
3.118E-1
 2 163
27 gudmap RNAseq e15.5 Mesangium 2500 K4 gudmap RNAseq e15.5 Mesangium 2500 K4 Gudmap RNAseq 5.461E-4 1.127E-2
7.806E-2
3.118E-1
 2 163
28 gudmap kidney single cell adult RenalCortexMixed Scamp 200 kidney single cell adult RenalCortexMixed StemCellamp top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.527E-4 1.127E-2
7.806E-2
3.156E-1
 2 164
29 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup5/Pvalb/Pvalb,Megf11,Pvalb BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup5/Pvalb/Pvalb,Megf11,Pvalb BrainMap 6.148E-4 1.134E-2
7.852E-2
3.510E-1
 2 173
30 gudmap kidney adult JuxtaGlom Ren1 k1 500 kidney adult JuxtaGlom Ren1 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.290E-4 1.134E-2
7.852E-2
3.592E-1
 2 175
31 Extraglomerular mesangium (EM)/Extraglomerular mesangium (EM) e Extraglomerular mesangium (EM)/Extraglomerular mesangium (EM) e 6.726E-4 1.134E-2
7.852E-2
3.841E-1
 2 181
32 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup1 Inhibitory.subGroup1 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup1 Inhibitory.subGroup1 Overall Top 200 Genes BrainMap 6.950E-4 1.134E-2
7.852E-2
3.968E-1
 2 184
33 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup1 Inhibitory.subGroup1 Top 200 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup1 Inhibitory.subGroup1 Top 200 BrainMap 6.950E-4 1.134E-2
7.852E-2
3.968E-1
 2 184
34 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Th Neuron.inhibitory.Th Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Th Neuron.inhibitory.Th Overall Top 200 Genes BrainMap 6.950E-4 1.134E-2
7.852E-2
3.968E-1
 2 184
35 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Th Neuron.inhibitory.Th Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Th Neuron.inhibitory.Th Top 200 BrainMap 6.950E-4 1.134E-2
7.852E-2
3.968E-1
 2 184
36 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal fetal kidney Nephron epithelium/Kidney Normal fetal kidney N13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal fetal kidney Nephron epithelium/Kidney Normal fetal kidney N13 Adult, Development, and Cancer types 7.253E-4 1.143E-2
7.917E-2
4.142E-1
 2 188
37 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal PapRCC EN-B Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal PapRCC EN-B Adult, Development, and Cancer types 7.407E-4 1.143E-2
7.917E-2
4.230E-1
 2 190
38 Kidney10XCellRanger Six2TGC TSC1 P0 RV RV Subtype P0-Six2TGC Tsc1-RV-C3-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 RV RV Subtype P0-Six2TGC Tsc1-RV-C3-KC7 Top 200 Genes 1.111E-3 1.669E-2
1.156E-1
6.342E-1
 2 233
39 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Medulla Wilms U U/Kidney Normal-Medulla Wilms U7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Medulla Wilms U U/Kidney Normal-Medulla Wilms U7 Adult, Development, and Cancer types 1.145E-3 1.676E-2
1.161E-1
6.537E-1
 1 5
40 adrenal gland adrenal gland Human Protein Atlas 1.257E-3 1.794E-2
1.243E-1
7.177E-1
 2 248
41 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.oligodendrocytes.Mbp Oligodendrocyte.oligodendrocytes.Mbp Subtype Oligodendrocyte.oligodendrocytes.Mbp.Tfr Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.oligodendrocytes.Mbp Oligodendrocyte.oligodendrocytes.Mbp Subtype Oligodendrocyte.oligodendrocytes.Mbp.Tfr Top 200 Genes BrainMap 1.476E-3 2.056E-2
1.424E-1
8.430E-1
 2 269
42 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr SubstantiaNigra Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr SubstantiaNigra Top 200 Genes BrainMap 1.598E-3 2.103E-2
1.457E-1
9.125E-1
 2 280
43 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes Oligodendrocyte.Pdgfa-hi oligodendrocytes Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes Oligodendrocyte.Pdgfa-hi oligodendrocytes Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Top 200 Genes BrainMap 1.621E-3 2.103E-2
1.457E-1
9.255E-1
 2 282
44 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup4 Inhibitory.subGroup4 Subtype Inhibitory.subGroup4 SubstantiaNigra Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup4 Inhibitory.subGroup4 Subtype Inhibitory.subGroup4 SubstantiaNigra Top 200 Genes BrainMap 1.621E-3 2.103E-2
1.457E-1
9.255E-1
 2 282
45 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 100 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.831E-3 2.324E-2
1.609E-1
1.000E0
 1 8
46 gudmap kidney adult JuxtaGlom Ren1 k4 1000 kidney adult JuxtaGlom Ren1 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.892E-3 2.349E-2
1.627E-1
1.000E0
 2 305
47 gudmap kidney adult CortVasc Tie2 k1 1000 kidney adult CortVasc Tie2 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.017E-3 2.376E-2
1.645E-1
1.000E0
 2 315
48 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s8 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s8 Top 200 Genes StanfordMouse+HumanSingleCells 2.042E-3 2.376E-2
1.645E-1
1.000E0
 2 317
49 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Th Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Th Top 200 Genes 2.184E-3 2.376E-2
1.645E-1
1.000E0
 2 328
50 Kidney10XCellRanger Six2KI P0 RV RV Subtype P0-Six2KI-RV-C1-KC10 Top 200 Genes Kidney10XCellRanger Six2KI P0 RV RV Subtype P0-Six2KI-RV-C1-KC10 Top 200 Genes 2.251E-3 2.376E-2
1.645E-1
1.000E0
 2 333
Show 45 more annotations

15: Computational [Display Chart] 4 input genes in category / 35 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3887 MODULE 78 AA metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.258E-5 7.903E-4 3.277E-3 7.903E-4 2 20
2 M2027 MODULE 212 Catalytic activities / metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.362E-4 2.384E-3 9.886E-3 4.768E-3 3 329
3 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.531E-4 2.740E-3 1.136E-2 1.236E-2 3 453
4 M3789 MODULE 235 AA and sulfur metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.819E-4 2.740E-3 1.136E-2 1.337E-2 2 81
5 M9683 MODULE 40 Organic acid metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.914E-4 2.740E-3 1.136E-2 1.370E-2 2 82
6 M10134 MODULE 93 Oxidoreductases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.916E-3 1.117E-2 4.634E-2
6.704E-2
 2 182
7 M2667 MODULE 19 Adrenal gland - metabolic genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.614E-3 2.807E-2
1.164E-1
1.965E-1
 2 314
8 M9013 MODULE 354 AA biosynthesis. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.155E-3 2.886E-2
1.197E-1
2.504E-1
 1 18
9 M14893 MODULE 295 Genes in the cancer module 295. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.344E-3 2.886E-2
1.197E-1
2.920E-1
 1 21
10 M741 MODULE 327 Genes in the cancer module 327. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.344E-3 2.886E-2
1.197E-1
2.920E-1
 1 21
11 M18696 MODULE 343 Nitrogen metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.927E-3 2.886E-2
1.197E-1
3.475E-1
 1 25
12 M8592 MODULE 135 Genes in the cancer module 135. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.927E-3 2.886E-2
1.197E-1
3.475E-1
 1 25
13 M14967 GCM ATM Neighborhood of ATM MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.072E-2 2.886E-2
1.197E-1
3.751E-1
 1 27
14 M19173 MODULE 280 Metal ion (zinc) binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.782E-2 4.249E-2
1.762E-1
6.236E-1
 1 45
15 M1621 GCM LTK Neighborhood of LTK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.821E-2 4.249E-2
1.762E-1
6.373E-1
 1 46
16 M18034 CAR IGFBP1 Neighborhood of IGFBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.253E-2 4.928E-2
2.043E-1
7.884E-1
 1 57
Show 11 more annotations

16: MicroRNA [Display Chart] 5 input genes in category / 59 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-648:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.699E-2
1.258E-1
3.016E-1
 1 74
2 hsa-miR-1911-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.699E-2
1.258E-1
3.056E-1
 1 75
3 hsa-miR-8077:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.249E-3 2.699E-2
1.258E-1
3.097E-1
 1 76
4 hsa-miR-541:PITA hsa-miR-541:PITA TOP PITA 5.387E-3 2.699E-2
1.258E-1
3.178E-1
 1 78
5 hsa-miR-4717-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 2.699E-2
1.258E-1
3.178E-1
 1 78
6 hsa-miR-4663:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.456E-3 2.699E-2
1.258E-1
3.219E-1
 1 79
7 hsa-miR-654-5p:PITA hsa-miR-654-5p:PITA TOP PITA 5.525E-3 2.699E-2
1.258E-1
3.260E-1
 1 80
8 hsa-miR-4693-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.453E-3 2.699E-2
1.258E-1
4.397E-1
 1 108
9 hsa-miR-655-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.553E-3 2.699E-2
1.258E-1
5.046E-1
 1 124
10 hsa-miR-95:mirSVR highEffct hsa-miR-95:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.828E-3 2.699E-2
1.258E-1
5.209E-1
 1 128
11 hsa-miR-4451:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.828E-3 2.699E-2
1.258E-1
5.209E-1
 1 128
12 hsa-miR-6132:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.828E-3 2.699E-2
1.258E-1
5.209E-1
 1 128
13 hsa-miR-6836-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.828E-3 2.699E-2
1.258E-1
5.209E-1
 1 128
14 hsa-miR-5584-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.859E-3 2.699E-2
1.258E-1
5.817E-1
 1 143
15 hsa-miR-4302:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.859E-3 2.699E-2
1.258E-1
5.817E-1
 1 143
16 hsa-miR-4645-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.996E-3 2.699E-2
1.258E-1
5.898E-1
 1 145
17 hsa-miR-4673:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.013E-2 2.699E-2
1.258E-1
5.979E-1
 1 147
18 hsa-miR-582-5p:Functional MTI Functional MTI miRTarbase 1.027E-2 2.699E-2
1.258E-1
6.060E-1
 1 149
19 hsa-miR-298:Functional MTI Functional MTI miRTarbase 1.137E-2 2.699E-2
1.258E-1
6.707E-1
 1 165
20 hsa-miR-6771-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.164E-2 2.699E-2
1.258E-1
6.869E-1
 1 169
21 hsa-miR-3186-3p:mirSVR lowEffct hsa-miR-3186-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.185E-2 2.699E-2
1.258E-1
6.991E-1
 1 172
22 hsa-miR-4692:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.212E-2 2.699E-2
1.258E-1
7.152E-1
 1 176
23 hsa-miR-4514:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.226E-2 2.699E-2
1.258E-1
7.233E-1
 1 178
24 hsa-miR-6722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.247E-2 2.699E-2
1.258E-1
7.354E-1
 1 181
25 hsa-miR-6124:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.247E-2 2.699E-2
1.258E-1
7.354E-1
 1 181
26 hsa-miR-1909-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.260E-2 2.699E-2
1.258E-1
7.435E-1
 1 183
27 hsa-miR-3927-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.267E-2 2.699E-2
1.258E-1
7.476E-1
 1 184
28 hsa-miR-6831-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.281E-2 2.699E-2
1.258E-1
7.557E-1
 1 186
29 hsa-miR-7851-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.370E-2 2.787E-2
1.300E-1
8.082E-1
 1 199
30 hsa-miR-6746-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.418E-2 2.788E-2
1.300E-1
8.365E-1
 1 206
31 hsa-miR-490-3p:Functional MTI Functional MTI miRTarbase 1.472E-2 2.802E-2
1.307E-1
8.687E-1
 1 214
32 hsa-miR-1973:mirSVR lowEffct hsa-miR-1973:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.787E-2 3.207E-2
1.496E-1
1.000E0
 1 260
33 hsa-miR-1273c:mirSVR lowEffct hsa-miR-1273c:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.828E-2 3.207E-2
1.496E-1
1.000E0
 1 266
34 hsa-miR-371a-5p:TargetScan hsa-miR-371a-5p TargetScan 1.889E-2 3.207E-2
1.496E-1
1.000E0
 1 275
35 hsa-miR-3192-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.903E-2 3.207E-2
1.496E-1
1.000E0
 1 277
36 hsa-miR-4458:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.141E-2 3.400E-2
1.585E-1
1.000E0
 1 312
37 hsa-miR-4500:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.141E-2 3.400E-2
1.585E-1
1.000E0
 1 312
38 hsa-miR-194-5p:TargetScan hsa-miR-194-5p TargetScan 2.263E-2 3.400E-2
1.585E-1
1.000E0
 1 330
39 hsa-let-7i-5p:Functional MTI Functional MTI miRTarbase 2.290E-2 3.400E-2
1.585E-1
1.000E0
 1 334
40 hsa-let-7g-5p:Functional MTI Functional MTI miRTarbase 2.338E-2 3.400E-2
1.585E-1
1.000E0
 1 341
41 hsa-miR-143-3p:TargetScan hsa-miR-143-3p TargetScan 2.365E-2 3.400E-2
1.585E-1
1.000E0
 1 345
42 hsa-miR-590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.670E-2 3.400E-2
1.585E-1
1.000E0
 1 390
43 hsa-miR-101-3p:Functional MTI Functional MTI miRTarbase 2.691E-2 3.400E-2
1.585E-1
1.000E0
 1 393
44 hsa-let-7d-5p:Functional MTI Functional MTI miRTarbase 2.697E-2 3.400E-2
1.585E-1
1.000E0
 1 394
45 hsa-let-7f-5p:Functional MTI Functional MTI miRTarbase 2.718E-2 3.400E-2
1.585E-1
1.000E0
 1 397
46 hsa-miR-638:mirSVR lowEffct hsa-miR-638:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.725E-2 3.400E-2
1.585E-1
1.000E0
 1 398
47 hsa-miR-4668-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.752E-2 3.400E-2
1.585E-1
1.000E0
 1 402
48 hsa-miR-331-3p:Functional MTI Functional MTI miRTarbase 2.779E-2 3.400E-2
1.585E-1
1.000E0
 1 406
49 hsa-miR-1234:mirSVR lowEffct hsa-miR-1234:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.894E-2 3.400E-2
1.585E-1
1.000E0
 1 423
50 hsa-miR-186-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.103E-2 3.400E-2
1.585E-1
1.000E0
 1 454
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 1783 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000156 H4biopterin Stitch 8.435E-17 1.504E-13 1.213E-12 1.504E-13 5 16
2 CID000002380 biopterin Stitch 5.269E-13 4.697E-10 3.788E-9 9.395E-10 5 82
3 CID006453850 DMPH2 Stitch 5.036E-12 1.958E-9 1.579E-8 8.979E-9 3 3
4 CID000129803 4alpha-hydroxytetrahydrobiopterin Stitch 5.574E-12 1.958E-9 1.579E-8 9.939E-9 4 25
5 CID000004455 neopterine Stitch 6.206E-12 1.958E-9 1.579E-8 1.107E-8 5 133
6 CID000104778 levodopa/carbidopa Stitch 6.588E-12 1.958E-9 1.579E-8 1.175E-8 4 26
7 CID000122134 tetrahydropterin Stitch 7.733E-12 1.970E-9 1.588E-8 1.379E-8 4 27
8 CID000001153 tyrosinate Stitch 1.067E-11 2.379E-9 1.918E-8 1.903E-8 5 148
9 CID000128973 dyspropterin Stitch 1.386E-11 2.746E-9 2.215E-8 2.472E-8 4 31
10 CID000000252 quinonoid dihydro-(6H)-biopterin Stitch 2.043E-11 3.643E-9 2.937E-8 3.643E-8 4 34
11 CID000001125 tetrahydrobiopterin Stitch 2.641E-11 4.280E-9 3.452E-8 4.709E-8 5 177
12 CID000001879 q-dihydrobiopterin Stitch 2.909E-11 4.323E-9 3.486E-8 5.187E-8 4 37
13 CID000005200 L-sepiapterin Stitch 1.617E-10 2.217E-8 1.788E-7 2.883E-7 4 56
14 CID000070488 0 FU Stitch 6.040E-10 7.693E-8 6.203E-7 1.077E-6 3 10
15 CID000073578 DMPH4 Stitch 8.305E-10 9.871E-8 7.960E-7 1.481E-6 3 11
16 CID000004652 p-chlorophenylalanine Stitch 9.338E-10 1.041E-7 8.391E-7 1.665E-6 4 86
17 CID000126227 7-BH4 Stitch 1.107E-9 1.161E-7 9.364E-7 1.974E-6 3 12
18 CID000114772 5-hydroxydopamine Stitch 1.439E-9 1.351E-7 1.089E-6 2.566E-6 3 13
19 CID005488923 7-biopterin Stitch 1.439E-9 1.351E-7 1.089E-6 2.566E-6 3 13
20 CID000001738 homovanillic acid Stitch 1.523E-9 1.358E-7 1.095E-6 2.716E-6 4 97
21 CID000000144 5-HTP Stitch 1.794E-9 1.484E-7 1.197E-6 3.199E-6 4 101
22 CID000011479 A26752 Stitch 1.832E-9 1.484E-7 1.197E-6 3.266E-6 3 14
23 CID000073000 pterin Stitch 2.355E-9 1.825E-7 1.472E-6 4.198E-6 4 108
24 CID000013153 TCAT Stitch 2.818E-9 2.010E-7 1.620E-6 5.024E-6 3 16
25 CID000003124 6-methyltetrahydropterin Stitch 2.818E-9 2.010E-7 1.620E-6 5.024E-6 3 16
26 CID000001826 5-HIAA Stitch 4.834E-9 3.222E-7 2.598E-6 8.619E-6 4 129
27 CID000000977 oxygen Stitch 4.880E-9 3.222E-7 2.598E-6 8.700E-6 5 499
28 CID000000682 AC1Q6BWO Stitch 7.745E-9 4.932E-7 3.977E-6 1.381E-5 3 22
29 CID000091738 AC1L3MP7 Stitch 2.041E-8 1.255E-6 1.012E-5 3.639E-5 3 30
30 CID000000836 3,4-dihydroxyphenylalanine Stitch 2.776E-8 1.650E-6 1.331E-5 4.950E-5 4 199
31 CID000000994 phenylalanine Stitch 3.317E-8 1.908E-6 1.538E-5 5.914E-5 4 208
32 CID000091528 DOPEG Stitch 3.588E-8 1.934E-6 1.559E-5 6.397E-5 3 36
33 CID000160199 oudenone Stitch 3.834E-8 1.934E-6 1.559E-5 6.835E-5 2 2
34 CID000100137 phenyl-TIQ Stitch 3.834E-8 1.934E-6 1.559E-5 6.835E-5 2 2
35 CID000134846 6,6-Me2PH4 Stitch 3.834E-8 1.934E-6 1.559E-5 6.835E-5 2 2
36 CID000002563 adjunct to levodopa in Parkinsonism Stitch 3.904E-8 1.934E-6 1.559E-5 6.961E-5 3 37
37 CID000009261 pyrazin Stitch 4.591E-8 2.213E-6 1.784E-5 8.186E-5 3 39
38 CID000004528 nomifensine Stitch 7.623E-8 3.577E-6 2.884E-5 1.359E-4 3 46
39 CID000006272 3-iodotyrosine Stitch 8.142E-8 3.722E-6 3.001E-5 1.452E-4 3 47
40 CID000016054 5-hydroxyindole Stitch 9.840E-8 4.386E-6 3.537E-5 1.754E-4 3 50
41 CID000003171 L-threo-DOPS Stitch 1.045E-7 4.546E-6 3.666E-5 1.864E-4 3 51
42 CID009570779 GYKI 11679 Stitch 1.150E-7 4.769E-6 3.845E-5 2.050E-4 2 3
43 DB04400 7,8-Dihydrobiopterin Drug Bank 1.150E-7 4.769E-6 3.845E-5 2.050E-4 2 3
44 CID000001245 vanillylmandelic acid Stitch 1.317E-7 5.335E-6 4.302E-5 2.348E-4 3 55
45 CID000010805 MHPG Stitch 1.468E-7 5.817E-6 4.691E-5 2.618E-4 3 57
46 CID000000665 AC1Q6S3P Stitch 1.992E-7 7.721E-6 6.226E-5 3.552E-4 3 63
47 CID000151513 L75-4 Stitch 2.300E-7 8.201E-6 6.613E-5 4.101E-4 2 4
48 CID000013122 aceperone Stitch 2.300E-7 8.201E-6 6.613E-5 4.101E-4 2 4
49 CID000195856 3'-hydroxysepiapterin Stitch 2.300E-7 8.201E-6 6.613E-5 4.101E-4 2 4
50 DB00360 Tetrahydrobiopterin Drug Bank 2.300E-7 8.201E-6 6.613E-5 4.101E-4 2 4
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18: Disease [Display Chart] 5 input genes in category / 289 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0031485 Phenylketonurias DisGeNET Curated 3.560E-11 1.029E-8 6.426E-8 1.029E-8 4 28
2 C0751434 Classical phenylketonuria DisGeNET Curated 9.577E-9 1.384E-6 8.643E-6 2.768E-6 3 17
3 C0751435 Hyperphenylalaninaemia DisGeNET Curated 2.168E-8 2.088E-6 1.304E-5 6.265E-6 3 22
4 C0040822 Tremor DisGeNET Curated 9.463E-8 6.837E-6 4.270E-5 2.735E-5 4 192
5 C0026826 Muscle Hypertonia DisGeNET Curated 1.535E-6 8.874E-5 5.542E-4 4.437E-4 3 88
6 C0751436 Hyperphenylalaninemia, Non-Phenylketonuric DisGeNET BeFree 2.131E-6 1.026E-4 6.411E-4 6.159E-4 2 8
7 C1847835 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) DisGeNET Curated 8.796E-6 3.296E-4 2.059E-3 2.542E-3 3 157
8 C1851920 Dopa-Responsive Dystonia DisGeNET Curated 9.124E-6 3.296E-4 2.059E-3 2.637E-3 2 16
9 C0042900 Vitiligo DisGeNET Curated 1.157E-5 3.715E-4 2.320E-3 3.343E-3 3 172
10 C0013421 Dystonia DisGeNET Curated 2.135E-5 6.170E-4 3.853E-3 6.170E-3 3 211
11 C4054122 Rat Adrenal Gland Pheochromocytoma DisGeNET BeFree 6.526E-5 1.675E-3 1.046E-2 1.886E-2 2 42
12 C0848332 Spots on skin DisGeNET BeFree 8.566E-5 1.675E-3 1.046E-2 2.476E-2 3 336
13 C0221765 Chronic schizophrenia DisGeNET Curated 8.905E-5 1.675E-3 1.046E-2 2.574E-2 2 49
14 C0270685 Cerebral calcification DisGeNET Curated 9.275E-5 1.675E-3 1.046E-2 2.681E-2 2 50
15 C0686347 Tardive Dyskinesia DisGeNET BeFree 9.275E-5 1.675E-3 1.046E-2 2.681E-2 2 50
16 C3714760 Drug-induced tardive dyskinesia DisGeNET BeFree 9.275E-5 1.675E-3 1.046E-2 2.681E-2 2 50
17 C0233514 Abnormal behavior DisGeNET Curated 1.096E-4 1.863E-3 1.164E-2 3.167E-2 3 365
18 C0015230 Exanthema DisGeNET Curated 1.675E-4 2.175E-3 1.358E-2 4.840E-2 3 421
19 C2700617 Irritation - emotion DisGeNET Curated 1.721E-4 2.175E-3 1.358E-2 4.974E-2 2 68
20 C0162835 Hypopigmentation disorder DisGeNET Curated 1.930E-4 2.175E-3 1.358E-2
5.578E-2
 2 72
21 C0030421 Paraganglioma DisGeNET Curated 2.566E-4 2.175E-3 1.358E-2
7.416E-2
 2 83
22 C0040517 Gilles de la Tourette syndrome DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.915E-2
 2 91
23 C0860515 Freezing of gait DisGeNET BeFree 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
24 C1849700 Hyperphenylalaninemia with primapterinuria DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
25 C0268463 Persistent hyperphenylalaninemia DisGeNET BeFree 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
26 C0403673 Retrograde ejaculation DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
27 cv:C1854299 Segawa syndrome, autosomal recessive Clinical Variations 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
28 cv:C0031485 Phenylketonuria Clinical Variations 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
29 OMIN:264070 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, D; HPABH4D OMIM 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
30 cv:C0268465 Dihydropteridine reductase deficiency Clinical Variations 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
31 OMIN:605407 SEGAWA SYNDROME, AUTOSOMAL RECESSIVE OMIM 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
32 C0085547 Phenylketonuria, Maternal DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
33 C0342687 dopamine beta hydroxylase deficiency DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
34 C4022014 Maternal hyperphenylalaninemia DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
35 C1849926 Phenylpyruvic acidemia DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
36 cv:C1857209 Dopamine beta hydroxylase deficiency Clinical Variations 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
37 cv:C1849700 Hyperphenylalaninemia, BH4-deficient, D Clinical Variations 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
38 OMIN:261630 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C; HPABH4C OMIM 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
39 C4025094 Reduced phenylalanine hydroxylase activity DisGeNET Curated 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
40 C0231367 Activity intolerance DisGeNET BeFree 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
41 OMIN:261600 PHENYLKETONURIA; PKU OMIM 3.085E-4 2.175E-3 1.358E-2
8.917E-2
 1 1
42 C0235031 Neurologic Symptoms DisGeNET BeFree 4.506E-4 3.100E-3 1.936E-2
1.302E-1
 2 110
43 C0028043 Nicotine Dependence DisGeNET BeFree 5.009E-4 3.367E-3 2.103E-2
1.448E-1
 2 116
44 C0393593 Dystonia Disorders DisGeNET Curated 5.814E-4 3.806E-3 2.377E-2
1.680E-1
 2 125
45 C1837639 Intermittent hypothermia DisGeNET Curated 6.170E-4 3.806E-3 2.377E-2
1.783E-1
 1 2
46 C0393610 Dystonia, Diurnal DisGeNET BeFree 6.170E-4 3.806E-3 2.377E-2
1.783E-1
 1 2
47 C0752347 Lewy Body Disease DisGeNET Curated 6.190E-4 3.806E-3 2.377E-2
1.789E-1
 2 129
48 C1854301 Motor delay DisGeNET Curated 8.468E-4 4.995E-3 3.119E-2
2.447E-1
 2 151
49 C4020874 No development of motor milestones DisGeNET Curated 8.468E-4 4.995E-3 3.119E-2
2.447E-1
 2 151
50 C0028734 Nocturia DisGeNET Curated 9.254E-4 5.143E-3 3.212E-2
2.674E-1
 1 3
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