Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc43_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 29 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005540 hyaluronic acid binding 4.395E-10 7.144E-9 2.830E-8 1.275E-8 4 24
2 GO:0005539 glycosaminoglycan binding 4.927E-10 7.144E-9 2.830E-8 1.429E-8 6 219
3 GO:0005201 extracellular matrix structural constituent 5.818E-8 5.624E-7 2.228E-6 1.687E-6 4 78
4 GO:0030246 carbohydrate binding 1.099E-5 7.971E-5 3.158E-4 3.188E-4 4 289
5 GO:0030380 interleukin-17E receptor binding 5.359E-4 3.108E-3 1.231E-2 1.554E-2 1 1
6 GO:0005518 collagen binding 6.475E-4 3.130E-3 1.240E-2 1.878E-2 2 72
7 GO:0005178 integrin binding 1.814E-3 7.514E-3 2.977E-2
5.260E-2
 2 121
8 GO:0045340 mercury ion binding 2.142E-3 7.765E-3 3.076E-2
6.212E-2
 1 4
9 GO:0030368 interleukin-17 receptor activity 4.280E-3 1.379E-2
5.463E-2
1.241E-1
 1 8
10 GO:0050839 cell adhesion molecule binding 5.246E-3 1.521E-2
6.027E-2
1.521E-1
 2 208
11 GO:0046625 sphingolipid binding 8.543E-3 2.252E-2
8.923E-2
2.477E-1
 1 16
Show 6 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 367 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030208 dermatan sulfate biosynthetic process 1.068E-14 2.123E-12 1.376E-11 3.920E-12 5 12
2 GO:0044273 sulfur compound catabolic process 1.384E-14 2.123E-12 1.376E-11 5.078E-12 6 40
3 GO:0030205 dermatan sulfate metabolic process 1.735E-14 2.123E-12 1.376E-11 6.368E-12 5 13
4 GO:0030207 chondroitin sulfate catabolic process 2.699E-14 2.476E-12 1.605E-11 9.904E-12 5 14
5 GO:0050651 dermatan sulfate proteoglycan biosynthetic process 4.047E-14 2.971E-12 1.926E-11 1.485E-11 5 15
6 GO:0050655 dermatan sulfate proteoglycan metabolic process 5.885E-14 3.600E-12 2.334E-11 2.160E-11 5 16
7 GO:0006027 glycosaminoglycan catabolic process 1.994E-13 1.045E-11 6.778E-11 7.317E-11 6 61
8 GO:0006026 aminoglycan catabolic process 3.925E-13 1.801E-11 1.168E-10 1.441E-10 6 68
9 GO:0030206 chondroitin sulfate biosynthetic process 7.144E-13 2.913E-11 1.889E-10 2.622E-10 5 25
10 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 2.282E-12 8.374E-11 5.430E-10 8.374E-10 5 31
11 GO:0006024 glycosaminoglycan biosynthetic process 1.000E-11 3.069E-10 1.990E-9 3.671E-9 6 115
12 GO:0006023 aminoglycan biosynthetic process 1.055E-11 3.069E-10 1.990E-9 3.871E-9 6 116
13 GO:0030204 chondroitin sulfate metabolic process 1.140E-11 3.069E-10 1.990E-9 4.182E-9 5 42
14 GO:1903510 mucopolysaccharide metabolic process 1.171E-11 3.069E-10 1.990E-9 4.297E-9 6 118
15 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1.636E-11 4.002E-10 2.595E-9 6.002E-9 5 45
16 GO:0030166 proteoglycan biosynthetic process 8.630E-11 1.903E-9 1.234E-8 3.167E-8 5 62
17 GO:0030198 extracellular matrix organization 9.661E-11 1.903E-9 1.234E-8 3.545E-8 7 354
18 GO:0030203 glycosaminoglycan metabolic process 9.687E-11 1.903E-9 1.234E-8 3.555E-8 6 167
19 GO:0043062 extracellular structure organization 9.853E-11 1.903E-9 1.234E-8 3.616E-8 7 355
20 GO:0006022 aminoglycan metabolic process 1.331E-10 2.443E-9 1.584E-8 4.886E-8 6 176
21 GO:1901136 carbohydrate derivative catabolic process 1.742E-10 3.045E-9 1.974E-8 6.394E-8 6 184
22 GO:0044272 sulfur compound biosynthetic process 5.126E-10 8.551E-9 5.544E-8 1.881E-7 6 220
23 GO:0006029 proteoglycan metabolic process 5.502E-10 8.779E-9 5.692E-8 2.019E-7 5 89
24 GO:1901565 organonitrogen compound catabolic process 1.069E-8 1.635E-7 1.060E-6 3.925E-6 6 365
25 GO:0006790 sulfur compound metabolic process 1.960E-8 2.877E-7 1.866E-6 7.193E-6 6 404
26 GO:0072330 monocarboxylic acid biosynthetic process 4.817E-8 6.800E-7 4.409E-6 1.768E-5 5 216
27 GO:0022617 extracellular matrix disassembly 1.145E-7 1.556E-6 1.009E-5 4.202E-5 4 92
28 GO:0016053 organic acid biosynthetic process 3.153E-7 3.991E-6 2.587E-5 1.157E-4 5 315
29 GO:0046394 carboxylic acid biosynthetic process 3.153E-7 3.991E-6 2.587E-5 1.157E-4 5 315
30 GO:0009101 glycoprotein biosynthetic process 6.110E-7 7.474E-6 4.846E-5 2.242E-4 5 360
31 GO:0009100 glycoprotein metabolic process 1.107E-6 1.310E-5 8.494E-5 4.061E-4 5 406
32 GO:0032634 interleukin-5 production 5.420E-5 6.216E-4 4.031E-3 1.989E-2 2 21
33 GO:0032616 interleukin-13 production 5.961E-5 6.629E-4 4.298E-3 2.188E-2 2 22
34 GO:0035924 cellular response to vascular endothelial growth factor stimulus 2.209E-4 2.384E-3 1.546E-2
8.107E-2
 2 42
35 GO:0008347 glial cell migration 3.136E-4 3.288E-3 2.132E-2
1.151E-1
 2 50
36 GO:0050803 regulation of synapse structure or activity 3.427E-4 3.494E-3 2.265E-2
1.258E-1
 3 272
37 GO:0018149 peptide cross-linking 4.077E-4 4.044E-3 2.622E-2
1.496E-1
 2 57
38 GO:0048692 negative regulation of axon extension involved in regeneration 5.370E-4 5.053E-3 3.276E-2
1.971E-1
 1 1
39 GO:0048688 negative regulation of sprouting of injured axon 5.370E-4 5.053E-3 3.276E-2
1.971E-1
 1 1
40 GO:0032103 positive regulation of response to external stimulus 5.926E-4 5.437E-3 3.526E-2
2.175E-1
 3 328
41 GO:0050804 modulation of chemical synaptic transmission 7.584E-4 6.789E-3 4.402E-2
2.783E-1
 3 357
42 GO:0048690 regulation of axon extension involved in regeneration 1.074E-3 8.756E-3
5.678E-2
3.940E-1
 1 2
43 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate 1.074E-3 8.756E-3
5.678E-2
3.940E-1
 1 2
44 GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate 1.074E-3 8.756E-3
5.678E-2
3.940E-1
 1 2
45 GO:0048686 regulation of sprouting of injured axon 1.074E-3 8.756E-3
5.678E-2
3.940E-1
 1 2
46 GO:0030516 regulation of axon extension 1.350E-3 1.077E-2
6.983E-2
4.954E-1
 2 104
47 GO:0001558 regulation of cell growth 1.435E-3 1.120E-2
7.265E-2
5.266E-1
 3 445
48 GO:0038044 transforming growth factor-beta secretion 1.610E-3 1.136E-2
7.368E-2
5.909E-1
 1 3
49 GO:2001202 negative regulation of transforming growth factor-beta secretion 1.610E-3 1.136E-2
7.368E-2
5.909E-1
 1 3
50 GO:0048677 axon extension involved in regeneration 1.610E-3 1.136E-2
7.368E-2
5.909E-1
 1 3
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 10 input genes in category / 27 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043202 lysosomal lumen 1.685E-12 3.885E-11 1.512E-10 4.549E-11 6 88
2 GO:0005796 Golgi lumen 2.878E-12 3.885E-11 1.512E-10 7.770E-11 6 96
3 GO:0005775 vacuolar lumen 9.178E-12 8.260E-11 3.214E-10 2.478E-10 6 116
4 GO:0031012 extracellular matrix 4.011E-10 2.708E-9 1.054E-8 1.083E-8 7 444
5 GO:0044420 extracellular matrix component 4.578E-5 2.472E-4 9.619E-4 1.236E-3 3 141
6 GO:0072534 perineuronal net 1.049E-3 4.721E-3 1.837E-2 2.832E-2 1 2
7 GO:0098647 collagen beaded filament 1.573E-3 5.309E-3 2.066E-2 4.248E-2 1 3
8 GO:0005589 collagen type VI trimer 1.573E-3 5.309E-3 2.066E-2 4.248E-2 1 3
9 GO:0005577 fibrinogen complex 4.713E-3 1.414E-2
5.502E-2
1.272E-1
 1 9
10 GO:0098644 complex of collagen trimers 1.200E-2 3.241E-2
1.261E-1
3.241E-1
 1 23
Show 5 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 160 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0005285 Absent nasal bridge 8.498E-4 4.532E-2
2.563E-1
1.360E-1
 1 1
2 HP:0008636 Lobular glomerulopathy 8.498E-4 4.532E-2
2.563E-1
1.360E-1
 1 1
3 HP:0004916 Generalized distal tubular acidosis 8.498E-4 4.532E-2
2.563E-1
1.360E-1
 1 1

5: Mouse Phenotype [Display Chart] 9 input genes in category / 344 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008712 decreased interleukin-9 secretion 1.875E-5 6.451E-3 4.141E-2 6.451E-3 2 8
2 MP:0008710 abnormal interleukin-9 secretion 4.412E-5 7.589E-3 4.872E-2 1.518E-2 2 12
3 MP:0010181 decreased susceptibility to weight loss 7.010E-5 8.038E-3
5.160E-2
 2.411E-2 2 15
4 MP:0008703 decreased interleukin-5 secretion 2.331E-4 1.604E-2
1.029E-1
8.018E-2
 2 27
5 MP:0008673 decreased interleukin-13 secretion 2.331E-4 1.604E-2
1.029E-1
8.018E-2
 2 27
6 MP:0008539 decreased susceptibility to induced colitis 3.497E-4 2.005E-2
1.287E-1
1.203E-1
 2 33
7 MP:0008701 abnormal interleukin-5 secretion 7.732E-4 3.737E-2
2.399E-1
2.660E-1
 2 49
8 MP:0003669 periodontal ligament hypercellularity 8.691E-4 3.737E-2
2.399E-1
2.990E-1
 1 1
9 MP:0008671 abnormal interleukin-13 secretion 1.009E-3 3.858E-2
2.476E-1
3.472E-1
 2 56
10 MP:0008722 abnormal chemokine secretion 1.316E-3 4.509E-2
2.895E-1
4.529E-1
 2 64
11 MP:0011118 abnormal susceptibility to weight loss 1.442E-3 4.509E-2
2.895E-1
4.960E-1
 2 67
12 MP:0012277 increased tail bud apoptosis 1.738E-3 4.898E-2
3.144E-1
5.977E-1
 1 2
13 MP:0005012 decreased eosinophil cell number 1.851E-3 4.898E-2
3.144E-1
6.368E-1
 2 76
Show 8 more annotations

6: Domain [Display Chart] 9 input genes in category / 94 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00022 EGF 1 PROSITE 4.983E-10 2.693E-8 1.380E-7 4.684E-8 6 256
2 IPR013032 EGF-like CS InterPro 5.730E-10 2.693E-8 1.380E-7 5.386E-8 6 262
3 PF00193 Xlink Pfam 2.187E-8 2.937E-7 1.505E-6 2.056E-6 3 13
4 PS01241 LINK 1 PROSITE 2.187E-8 2.937E-7 1.505E-6 2.056E-6 3 13
5 IPR000538 Link dom InterPro 2.187E-8 2.937E-7 1.505E-6 2.056E-6 3 13
6 SM00445 LINK SMART 2.187E-8 2.937E-7 1.505E-6 2.056E-6 3 13
7 PS50963 LINK 2 PROSITE 2.187E-8 2.937E-7 1.505E-6 2.056E-6 3 13
8 SM00181 EGF SMART 3.676E-8 3.840E-7 1.968E-6 3.456E-6 5 236
9 PS50026 EGF 3 PROSITE 3.676E-8 3.840E-7 1.968E-6 3.456E-6 5 236
10 IPR000742 EGF-like dom InterPro 4.904E-8 4.609E-7 2.363E-6 4.609E-6 5 250
11 PS01186 EGF 2 PROSITE 6.684E-8 5.712E-7 2.928E-6 6.283E-6 5 266
12 IPR018378 C-type lectin CS InterPro 9.369E-7 7.339E-6 3.762E-5 8.807E-5 3 43
13 PF00084 Sushi Pfam 1.674E-6 1.211E-5 6.205E-5 1.574E-4 3 52
14 SM00032 CCP SMART 1.878E-6 1.261E-5 6.464E-5 1.765E-4 3 54
15 PS50923 SUSHI PROSITE 2.098E-6 1.301E-5 6.667E-5 1.972E-4 3 56
16 IPR000436 Sushi SCR CCP dom InterPro 2.214E-6 1.301E-5 6.667E-5 2.081E-4 3 57
17 PS00615 C TYPE LECTIN 1 PROSITE 6.182E-6 3.419E-5 1.752E-4 5.811E-4 3 80
18 SM00034 CLECT SMART 7.163E-6 3.442E-5 1.764E-4 6.733E-4 3 84
19 PF00059 Lectin C Pfam 7.163E-6 3.442E-5 1.764E-4 6.733E-4 3 84
20 PS50041 C TYPE LECTIN 2 PROSITE 7.423E-6 3.442E-5 1.764E-4 6.978E-4 3 85
21 IPR001304 C-type lectin-like InterPro 7.690E-6 3.442E-5 1.764E-4 7.228E-4 3 86
22 3.10.100.10 - Gene3D 1.105E-5 4.721E-5 2.420E-4 1.039E-3 3 97
23 IPR016186 C-type lectin-like/link InterPro 1.175E-5 4.802E-5 2.461E-4 1.104E-3 3 99
24 IPR016187 CTDL fold InterPro 1.484E-5 5.812E-5 2.979E-4 1.395E-3 3 107
25 PF00008 EGF Pfam 2.422E-5 9.108E-5 4.669E-4 2.277E-3 3 126
26 PF07686 V-set Pfam 7.617E-5 2.754E-4 1.412E-3 7.160E-3 3 185
27 IPR013106 Ig V-set InterPro 9.601E-5 3.343E-4 1.713E-3 9.025E-3 3 200
28 IPR009505 Neural ProG Cyt InterPro 4.804E-4 1.368E-3 7.014E-3 4.516E-2 1 1
29 PF06566 Chon Sulph att Pfam 4.804E-4 1.368E-3 7.014E-3 4.516E-2 1 1
30 PF06567 Neural ProG Cyt Pfam 4.804E-4 1.368E-3 7.014E-3 4.516E-2 1 1
31 IPR028549 Decorin InterPro 4.804E-4 1.368E-3 7.014E-3 4.516E-2 1 1
32 IPR033079 TNR InterPro 4.804E-4 1.368E-3 7.014E-3 4.516E-2 1 1
33 IPR010555 Chon Sulph att InterPro 4.804E-4 1.368E-3 7.014E-3 4.516E-2 1 1
34 IPR003599 Ig sub InterPro 8.556E-4 2.298E-3 1.178E-2
8.043E-2
 3 421
35 SM00409 IG SMART 8.556E-4 2.298E-3 1.178E-2
8.043E-2
 3 421
36 IPR018097 EGF Ca-bd CS InterPro 9.328E-4 2.329E-3 1.194E-2
8.768E-2
 2 97
37 IPR032356 IL17R fnIII D1 InterPro 9.606E-4 2.329E-3 1.194E-2
9.029E-2
 1 2
38 PF16556 IL17R fnIII D1 Pfam 9.606E-4 2.329E-3 1.194E-2
9.029E-2
 1 2
39 PS01187 EGF CA PROSITE 9.714E-4 2.329E-3 1.194E-2
9.131E-2
 2 99
40 PS00010 ASX HYDROXYL PROSITE 9.909E-4 2.329E-3 1.194E-2
9.315E-2
 2 100
41 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 1.112E-3 2.550E-3 1.307E-2
1.046E-1
 2 106
42 PS50835 IG LIKE PROSITE 1.344E-3 3.007E-3 1.541E-2
1.263E-1
 3 492
43 IPR016352 SLRP I decor/aspor/byglycan InterPro 1.441E-3 3.139E-3 1.609E-2
1.354E-1
 1 3
44 SM00179 EGF CA SMART 1.470E-3 3.139E-3 1.609E-2
1.381E-1
 2 122
45 IPR001881 EGF-like Ca-bd dom InterPro 1.518E-3 3.170E-3 1.625E-2
1.426E-1
 2 124
46 PS51091 FN1 2 PROSITE 1.920E-3 3.610E-3 1.851E-2
1.805E-1
 1 4
47 IPR000083 Fibronectin type1 InterPro 1.920E-3 3.610E-3 1.851E-2
1.805E-1
 1 4
48 PS01253 FN1 1 PROSITE 1.920E-3 3.610E-3 1.851E-2
1.805E-1
 1 4
49 SM00058 FN1 SMART 1.920E-3 3.610E-3 1.851E-2
1.805E-1
 1 4
50 PF00039 fn1 Pfam 1.920E-3 3.610E-3 1.851E-2
1.805E-1
 1 4
Show 45 more annotations

7: Pathway [Display Chart] 10 input genes in category / 117 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269016 Defective CHSY1 causes TPBS BioSystems: REACTOME 2.123E-15 8.281E-14 4.425E-13 2.484E-13 5 7
2 1269017 Defective CHST3 causes SEDCJD BioSystems: REACTOME 2.123E-15 8.281E-14 4.425E-13 2.484E-13 5 7
3 1269018 Defective CHST14 causes EDS, musculocontractural type BioSystems: REACTOME 2.123E-15 8.281E-14 4.425E-13 2.484E-13 5 7
4 1269011 Diseases associated with glycosaminoglycan metabolism BioSystems: REACTOME 9.307E-15 2.722E-13 1.455E-12 1.089E-12 6 26
5 1269986 Dermatan sulfate biosynthesis BioSystems: REACTOME 4.665E-14 1.092E-12 5.833E-12 5.458E-12 5 11
6 1269987 CS/DS degradation BioSystems: REACTOME 2.019E-13 3.938E-12 2.104E-11 2.363E-11 5 14
7 1269015 Defective B3GAT3 causes JDSSDHD BioSystems: REACTOME 1.171E-12 1.522E-11 8.135E-11 1.370E-10 5 19
8 1309217 Defective B3GALT6 causes EDSP2 and SEMDJL1 BioSystems: REACTOME 1.171E-12 1.522E-11 8.135E-11 1.370E-10 5 19
9 1269014 Defective B4GALT7 causes EDS, progeroid type BioSystems: REACTOME 1.171E-12 1.522E-11 8.135E-11 1.370E-10 5 19
10 1270256 ECM proteoglycans BioSystems: REACTOME 1.454E-12 1.702E-11 9.094E-11 1.702E-10 6 57
11 1269985 Chondroitin sulfate biosynthesis BioSystems: REACTOME 2.649E-12 2.818E-11 1.506E-10 3.100E-10 5 22
12 1269981 A tetrasaccharide linker sequence is required for GAG synthesis BioSystems: REACTOME 6.609E-12 6.444E-11 3.443E-10 7.732E-10 5 26
13 1269010 Diseases of glycosylation BioSystems: REACTOME 1.869E-11 1.682E-10 8.990E-10 2.187E-9 6 86
14 M5882 Genes encoding proteoglycans MSigDB C2 BIOCARTA (v6.0) 3.252E-11 2.717E-10 1.452E-9 3.804E-9 5 35
15 1269972 Glycosaminoglycan metabolism BioSystems: REACTOME 1.845E-10 1.439E-9 7.690E-9 2.159E-8 6 125
16 1269984 Chondroitin sulfate/dermatan sulfate metabolism BioSystems: REACTOME 2.588E-10 1.856E-9 9.918E-9 3.028E-8 5 52
17 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v6.0) 2.697E-10 1.856E-9 9.918E-9 3.155E-8 7 275
18 1269980 Heparan sulfate/heparin (HS-GAG) metabolism BioSystems: REACTOME 3.148E-10 2.046E-9 1.093E-8 3.683E-8 5 54
19 1270244 Extracellular matrix organization BioSystems: REACTOME 4.737E-10 2.917E-9 1.559E-8 5.542E-8 7 298
20 1269957 Metabolism of carbohydrates BioSystems: REACTOME 3.397E-8 1.987E-7 1.062E-6 3.974E-6 6 297
21 1383037 Interleukin-17 signaling BioSystems: REACTOME 1.622E-5 9.035E-5 4.828E-4 1.897E-3 2 8
22 1270257 Degradation of the extracellular matrix BioSystems: REACTOME 8.123E-5 4.320E-4 2.308E-3 9.504E-3 3 112
23 83068 ECM-receptor interaction BioSystems: KEGG 1.863E-3 9.479E-3
5.065E-2
2.180E-1
 2 82
24 1474301 IL-17 signaling pathway BioSystems: KEGG 2.389E-3 1.165E-2
6.224E-2
2.795E-1
 2 93
25 1270250 Fibronectin matrix formation BioSystems: REACTOME 4.811E-3 2.251E-2
1.203E-1
5.628E-1
 1 6
26 1269019 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) BioSystems: REACTOME 5.610E-3 2.344E-2
1.253E-1
6.564E-1
 1 7
27 1269020 Defective CHST6 causes MCDC1 BioSystems: REACTOME 5.610E-3 2.344E-2
1.253E-1
6.564E-1
 1 7
28 1309216 Defective ST3GAL3 causes MCT12 and EIEE15 BioSystems: REACTOME 5.610E-3 2.344E-2
1.253E-1
6.564E-1
 1 7
29 1269979 Keratan sulfate degradation BioSystems: REACTOME 9.600E-3 3.873E-2
2.070E-1
1.000E0
 1 12
30 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v6.0) 1.021E-2 3.968E-2
2.120E-1
1.000E0
 2 196
31 83067 Focal adhesion BioSystems: KEGG 1.051E-2 3.968E-2
2.120E-1
1.000E0
 2 199
32 782000 Proteoglycans in cancer BioSystems: KEGG 1.092E-2 3.994E-2
2.134E-1
1.000E0
 2 203
33 1269361 p130Cas linkage to MAPK signaling for integrins BioSystems: REACTOME 1.278E-2 4.398E-2
2.350E-1
1.000E0
 1 16
34 1269360 GRB2:SOS provides linkage to MAPK signaling for Integrins BioSystems: REACTOME 1.278E-2 4.398E-2
2.350E-1
1.000E0
 1 16
35 137952 Syndecan-3-mediated signaling events BioSystems: Pathway Interaction Database 1.358E-2 4.538E-2
2.425E-1
1.000E0
 1 17
Show 30 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 2291 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26472242 Muscleblind-like 1 is required for normal heart valve development in vivo. Pubmed 7.444E-16 1.705E-12 1.418E-11 1.705E-12 5 14
2 11038354 The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. Pubmed 1.184E-14 1.357E-11 1.128E-10 2.713E-11 4 5
3 12684764 Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Pubmed 5.629E-12 4.299E-9 3.574E-8 1.290E-8 4 17
4 10766023 Lecticans: organizers of the brain extracellular matrix. Pubmed 1.292E-11 5.922E-9 4.924E-8 2.961E-8 3 3
5 9294172 The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Pubmed 1.292E-11 5.922E-9 4.924E-8 2.961E-8 3 3
6 25344368 Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes. Pubmed 1.729E-11 6.602E-9 5.489E-8 3.961E-8 4 22
7 15694392 Extracellular matrix alterations in brains lacking four of its components. Pubmed 5.169E-11 1.184E-8 9.846E-8 1.184E-7 3 4
8 29367009 Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components. Pubmed 5.169E-11 1.184E-8 9.846E-8 1.184E-7 3 4
9 23637166 Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. Pubmed 5.169E-11 1.184E-8 9.846E-8 1.184E-7 3 4
10 28512860 Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules. Pubmed 5.169E-11 1.184E-8 9.846E-8 1.184E-7 3 4
11 20950796 Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. Pubmed 1.549E-9 3.227E-7 2.683E-6 3.550E-6 3 10
12 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 9.555E-9 1.824E-6 1.517E-5 2.189E-5 4 101
13 27068509 Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Pubmed 4.227E-8 5.235E-6 4.353E-5 9.684E-5 4 146
14 23201264 Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
15 27000993 Non-CSCs nourish CSCs through interleukin-17E-mediated activation of NF-κB and JAK/STAT3 signaling in human hepatocellular carcinoma. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
16 19683574 Differential proteoglycan expression in two spinal cord regions after dorsal root injury. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
17 24407884 IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
18 11058597 IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
19 21570719 Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
20 11714825 Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
21 9188753 A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
22 21791066 Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
23 21224775 Outcome of lumbar epidural steroid injection is predicted by assay of a complex of fibronectin and aggrecan from epidural lavage. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
24 11932252 Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
25 19015310 A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
26 19342692 Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
27 1747115 Interaction of the small proteoglycan decorin with fibronectin. Involvement of the sequence NKISK of the core protein. Pubmed 6.170E-8 5.235E-6 4.353E-5 1.414E-4 2 2
28 18621549 Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
29 26560039 IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
30 21997179 Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
31 14724283 Link protein has greater affinity for versican than aggrecan. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
32 15336555 Pancreatic tumor cells influence the composition of the extracellular matrix. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
33 18768888 Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
34 19141078 Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
35 28421819 IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
36 1696875 TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
37 22329809 Regional variation in human supraspinatus tendon proteoglycans: decorin, biglycan, and aggrecan. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
38 10400671 Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
39 12888576 Distinct interaction of versican/PG-M with hyaluronan and link protein. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
40 15590670 Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
41 24247484 IL-25 and IL-25 receptor expression on eosinophils from subjects with allergic asthma. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
42 17097211 Pre-eclampsia-associated alterations in decorin, biglycan and versican of the umbilical cord vein wall. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
43 21185747 Differential proteoglycan and hyaluronan distribution in calcified aortic valves. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
44 11486035 Neurocan is dispensable for brain development. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
45 19669783 Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Pubmed 1.851E-7 9.422E-6 7.834E-5 4.240E-4 2 3
46 23945235 Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. Pubmed 3.701E-7 1.631E-5 1.356E-4 8.479E-4 2 4
47 19828636 Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. Pubmed 3.701E-7 1.631E-5 1.356E-4 8.479E-4 2 4
48 22543263 Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology. Pubmed 3.701E-7 1.631E-5 1.356E-4 8.479E-4 2 4
49 11027579 The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Pubmed 3.701E-7 1.631E-5 1.356E-4 8.479E-4 2 4
50 9676579 Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations. Pubmed 3.701E-7 1.631E-5 1.356E-4 8.479E-4 2 4
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 872 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TNR TNR interactions 1.398E-12 1.219E-9 8.956E-9 1.219E-9 5 27
2 int:FBLN2 FBLN2 interactions 5.425E-10 2.365E-7 1.738E-6 4.731E-7 4 24
3 int:MMP2 MMP2 interactions 1.999E-8 5.810E-6 4.269E-5 1.743E-5 4 57
4 int:BCAN BCAN interactions 7.241E-8 1.578E-5 1.160E-4 6.314E-5 3 16
5 int:MMP3 MMP3 interactions 4.706E-7 6.840E-5 5.026E-4 4.104E-4 3 29
6 int:VCAN VCAN interactions 4.706E-7 6.840E-5 5.026E-4 4.104E-4 3 29
7 int:IL25 IL25 interactions 8.613E-7 1.000E-4 7.351E-4 7.511E-4 2 3
8 int:ADAMTS4 ADAMTS4 interactions 9.177E-7 1.000E-4 7.351E-4 8.003E-4 3 36
9 int:FBLN1 FBLN1 interactions 6.381E-6 6.182E-4 4.543E-3 5.564E-3 3 68
10 int:MMP8 MMP8 interactions 8.027E-6 6.363E-4 4.676E-3 6.999E-3 2 8
11 int:TNC TNC interactions 8.027E-6 6.363E-4 4.676E-3 6.999E-3 2 8
12 int:HAPLN1 HAPLN1 interactions 1.032E-5 7.497E-4 5.509E-3 8.997E-3 2 9
13 int:CXCL12 CXCL12 interactions 1.890E-5 1.268E-3 9.315E-3 1.648E-2 2 12
14 int:COL4A4 COL4A4 interactions 2.233E-5 1.298E-3 9.538E-3 1.947E-2 2 13
15 int:NCAN NCAN interactions 2.233E-5 1.298E-3 9.538E-3 1.947E-2 2 13
16 int:FBN1 FBN1 interactions 3.888E-5 2.118E-3 1.557E-2 3.391E-2 2 17
17 int:COL4A6 COL4A6 interactions 4.373E-5 2.118E-3 1.557E-2 3.813E-2 2 18
18 int:ACAN ACAN interactions 4.373E-5 2.118E-3 1.557E-2 3.813E-2 2 18
19 int:MMP1 MMP1 interactions 4.886E-5 2.242E-3 1.648E-2 4.261E-2 2 19
20 int:COL4A3 COL4A3 interactions 5.997E-5 2.615E-3 1.921E-2
5.229E-2
 2 21
21 int:ADAMTS1 ADAMTS1 interactions 7.874E-5 3.270E-3 2.403E-2
6.866E-2
 2 24
22 int:IL17RB IL17RB interactions 1.157E-4 4.584E-3 3.369E-2
1.009E-1
 2 29
23 int:PLA2G2A PLA2G2A interactions 1.239E-4 4.697E-3 3.451E-2
1.080E-1
 2 30
24 int:COL4A5 COL4A5 interactions 1.412E-4 5.129E-3 3.769E-2
1.231E-1
 2 32
25 int:C1QA C1QA interactions 1.502E-4 5.240E-3 3.851E-2
1.310E-1
 2 33
26 int:COL4A1 COL4A1 interactions 1.596E-4 5.352E-3 3.933E-2
1.391E-1
 2 34
27 int:DCN DCN interactions 1.791E-4 5.784E-3 4.250E-2
1.562E-1
 2 36
28 int:MMP7 MMP7 interactions 1.997E-4 6.220E-3 4.571E-2
1.742E-1
 2 38
29 int:PLAT PLAT interactions 2.215E-4 6.659E-3 4.893E-2
1.931E-1
 2 40
30 int:PEX5L PEX5L interactions 2.807E-4 8.158E-3
5.995E-2
2.447E-1
 2 45
31 int:COL1A2 COL1A2 interactions 2.933E-4 8.251E-3
6.063E-2
2.558E-1
 2 46
32 int:TAFA4 TAFA4 interactions 3.897E-4 1.062E-2
7.804E-2
3.398E-1
 2 53
33 int:THBS1 THBS1 interactions 4.046E-4 1.069E-2
7.856E-2
3.528E-1
 2 54
34 int:RPS6KA5 RPS6KA5 interactions 6.795E-4 1.741E-2
1.280E-1
5.925E-1
 2 70
35 int:COL1A1 COL1A1 interactions 6.990E-4 1.741E-2
1.280E-1
6.095E-1
 2 71
36 int:MMP19 MMP19 interactions 1.129E-3 2.592E-2
1.905E-1
9.849E-1
 1 2
37 int:MMP20 MMP20 interactions 1.129E-3 2.592E-2
1.905E-1
9.849E-1
 1 2
38 int:RPL23AP42 RPL23AP42 interactions 1.129E-3 2.592E-2
1.905E-1
9.849E-1
 1 2
39 int:TNFAIP6 TNFAIP6 interactions 1.694E-3 3.357E-2
2.467E-1
1.000E0
 1 3
40 int:TIMD4 TIMD4 interactions 1.694E-3 3.357E-2
2.467E-1
1.000E0
 1 3
41 int:IL17B IL17B interactions 1.694E-3 3.357E-2
2.467E-1
1.000E0
 1 3
42 int:FAM86B3P FAM86B3P interactions 1.694E-3 3.357E-2
2.467E-1
1.000E0
 1 3
43 int:ADAMTS5 ADAMTS5 interactions 1.694E-3 3.357E-2
2.467E-1
1.000E0
 1 3
44 int:IGKV3-20 IGKV3-20 interactions 1.694E-3 3.357E-2
2.467E-1
1.000E0
 1 3
45 int:HMGB1 HMGB1 interactions 2.145E-3 3.938E-2
2.894E-1
1.000E0
 2 125
46 int:CCN4 CCN4 interactions 2.258E-3 3.938E-2
2.894E-1
1.000E0
 1 4
47 int:MIA MIA interactions 2.258E-3 3.938E-2
2.894E-1
1.000E0
 1 4
48 int:CCL20 CCL20 interactions 2.258E-3 3.938E-2
2.894E-1
1.000E0
 1 4
49 int:SIGLEC1 SIGLEC1 interactions 2.258E-3 3.938E-2
2.894E-1
1.000E0
 1 4
50 int:PPIAP22 PPIAP22 interactions 2.258E-3 3.938E-2
2.894E-1
1.000E0
 1 4
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q21.33 12q21.33 3.745E-3 1.782E-2
5.219E-2
 3.745E-2 1 13
2 1q31 1q31 5.469E-3 1.782E-2
5.219E-2
5.469E-2
 1 19
3 1q24 1q24 6.043E-3 1.782E-2
5.219E-2
6.043E-2
 1 21
4 2q34 2q34 8.336E-3 1.782E-2
5.219E-2
8.336E-2
 1 29
5 5q14.3 5q14.3 8.909E-3 1.782E-2
5.219E-2
8.909E-2
 1 31
6 3p21.1 3p21.1 1.291E-2 2.151E-2
6.302E-2
1.291E-1
 1 45
7 3p21.3 3p21.3 1.718E-2 2.218E-2
6.497E-2
1.718E-1
 1 60
8 15q26.1 15q26.1 1.775E-2 2.218E-2
6.497E-2
1.775E-1
 1 62
9 19p12 19p12 2.623E-2 2.915E-2
8.537E-2
2.623E-1
 1 92
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 52 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 9 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 574 Hyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing genenames.org 2.761E-14 2.761E-13 8.086E-13 2.761E-13 4 4
2 1298 C-type lectin domain containing genenames.org 2.773E-9 1.387E-8 4.061E-8 2.773E-8 4 41
3 1179 Apolipoproteins|Sushi domain containing genenames.org 1.078E-8 3.593E-8 1.052E-7 1.078E-7 4 57
4 590 Receptor Tyrosine Kinases|CD molecules|V-set domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 7.555E-7 1.889E-6 5.532E-6 7.555E-6 4 163
5 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 2.657E-3 5.314E-3 1.556E-2 2.657E-2 2 160
6 542 Endogenous ligands genenames.org 5.727E-3 8.460E-3 2.478E-2
5.727E-2
 2 237
7 573 Small leucine rich repeat proteoglycans genenames.org 5.922E-3 8.460E-3 2.478E-2
5.922E-2
 1 12
8 554 Fibrinogen C domain containing|Fibronectin type III domain containing genenames.org 1.230E-2 1.538E-2 4.504E-2
1.230E-1
 1 25
9 602 Fibronectin type III domain containing|Interleukin receptors genenames.org 2.059E-2 2.108E-2
6.173E-2
2.059E-1
 1 42
10 601 Interleukins|PDZ domain containing genenames.org 2.108E-2 2.108E-2
6.173E-2
2.108E-1
 1 43
Show 5 more annotations

13: Coexpression [Display Chart] 10 input genes in category / 1184 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12679940-Table1 Human Pancreas Tan03 30genes OverExpressed GeneSigDB 1.894E-7 2.242E-4 1.716E-3 2.242E-4 3 28
2 15318932-Table3 Human Breast Abba04 52genes DCIS v IDC GeneSigDB 1.127E-6 6.674E-4 5.109E-3 1.335E-3 3 50
3 M2572 Invasiveness signature resulting from cancer cell/microenvironment interaction. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.389E-6 9.429E-4 7.217E-3 2.829E-3 3 64
4 16135788-Table13 Human Breast Wang05 410genes up BT-BAF57cells GeneSigDB 3.604E-6 9.858E-4 7.546E-3 4.267E-3 4 270
5 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.163E-6 9.858E-4 7.546E-3 4.929E-3 4 280
6 M9172 Genes down-regulated in primary keratinocytes at 1 h after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.552E-6 1.490E-3 1.141E-2 8.941E-3 2 10
7 14996721-Table1a Human Kidney Struckmann04 12genes GeneSigDB 1.107E-5 1.873E-3 1.433E-2 1.311E-2 2 12
8 M2070 Down-regulated genes common to all pretumorigenic cells with acquired drug resistance. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.308E-5 1.936E-3 1.482E-2 1.549E-2 2 13
9 M1767 Cluster B: genes down-regulated in primary lung tumors driven by KRAS [GeneID=3845] activation and loss of STK11 [GeneID=6794]; also up-regulated in human squamous cell carcinoma (SCC) vs adenocarcinoma subtype of NSCLC (non-small cell lung cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.279E-5 2.767E-3 2.118E-2 2.698E-2 2 17
10 15520187-Table2a Human Bladder Nicholson04 20genes Gain GeneSigDB 3.181E-5 2.767E-3 2.118E-2 3.767E-2 2 20
11 15950496-Table2b Human Leukemia Gebauer05 20genes PHCCells GeneSigDB 3.181E-5 2.767E-3 2.118E-2 3.767E-2 2 20
12 18724390-Table3 Human Bladder Wu08 24genes GeneSigDB 3.181E-5 2.767E-3 2.118E-2 3.767E-2 2 20
13 M2273 Genes up-regulated in A549 cells (lung adenocarcinoma) upon SKIL [GeneID=6498] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.181E-5 2.767E-3 2.118E-2 3.767E-2 2 20
14 15374961-TableS2 Human Brain Freije04 595genes GeneSigDB 3.312E-5 2.767E-3 2.118E-2 3.921E-2 4 474
15 20145155-TableS2 Human StemCell Lottaz10 24genes GeneSigDB 3.866E-5 2.767E-3 2.118E-2 4.577E-2 2 22
16 17952125-Table1a Human Pancreas Harada08 34genes GeneSigDB 3.866E-5 2.767E-3 2.118E-2 4.577E-2 2 22
17 17389037-Tab5 Human Breast Turashvili07 201genes GeneSigDB 3.972E-5 2.767E-3 2.118E-2 4.703E-2 3 163
18 17389037-Tab6 Human Breast Turashvili07 208genes GeneSigDB 4.582E-5 3.014E-3 2.307E-2
5.425E-2
 3 171
19 15355895-Table2a Human Bone Dring04 28genes GeneSigDB 5.434E-5 3.308E-3 2.532E-2
6.434E-2
 2 26
20 M3804 Genes up-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.791E-5 3.308E-3 2.532E-2
6.857E-2
 3 185
21 12644218-Table1 Human Bladder Ying-Hao02 30genes GeneSigDB 5.867E-5 3.308E-3 2.532E-2
6.947E-2
 2 27
22 17699763-Table2 Human Pancreas Nakamura07 43genes GeneSigDB 6.784E-5 3.458E-3 2.647E-2
8.032E-2
 2 29
23 M18395 Genes down-regulated in primary adipocytes compared to preadipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.267E-5 3.458E-3 2.647E-2
8.604E-2
 2 30
24 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v6.0) 7.301E-5 3.458E-3 2.647E-2
8.645E-2
 3 200
25 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v6.0) 7.301E-5 3.458E-3 2.647E-2
8.645E-2
 3 200
26 12136251-table4 Human Liver Li02 38genes GeneSigDB 8.814E-5 4.014E-3 3.072E-2
1.044E-1
 2 33
27 14583454-Table4 Human Brain Godard03 36genes GeneSigDB 9.928E-5 4.354E-3 3.332E-2
1.175E-1
 2 35
28 14583454-TableS1 Human Brain Godard03 239genes GeneSigDB 1.049E-4 4.436E-3 3.396E-2
1.242E-1
 3 226
29 M7883 Genes most strongly up-regulated in kidney glomeruli isolated from TCF21 [GeneID=6943] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.111E-4 4.535E-3 3.471E-2
1.315E-1
 2 37
30 14871811-Table3 Human Breast Amatschek04 39genes GeneSigDB 1.235E-4 4.875E-3 3.732E-2
1.463E-1
 2 39
31 M1713 Genes enriched in astrocytes in the adult mouse brain identified through correlation-based searches seeded with the astrocyte cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.434E-4 5.181E-3 3.965E-2
1.698E-1
 2 42
32 14767473-Table1 Human Pancreas Nakamura04 43genes GeneSigDB 1.434E-4 5.181E-3 3.965E-2
1.698E-1
 2 42
33 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.517E-4 5.181E-3 3.965E-2
1.796E-1
 3 256
34 M12085 Genes up-regulated by RUNX1-RUNX1T1 [GeneID=861;862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing erythroid lineage. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.575E-4 5.181E-3 3.965E-2
1.865E-1
 2 44
35 M7585 Genes up-regulated in ductal carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.575E-4 5.181E-3 3.965E-2
1.865E-1
 2 44
36 15374961-Table2 Human Brain Freije04 44genes GeneSigDB 1.575E-4 5.181E-3 3.965E-2
1.865E-1
 2 44
37 18702172-Table3 Human MesenchymalStemCells Boeuf08 51genes GeneSigDB 1.799E-4 5.756E-3 4.406E-2
2.130E-1
 2 47
38 17122647-Table3 Human Viral VanMeter06 56genes GeneSigDB 1.956E-4 5.938E-3 4.545E-2
2.316E-1
 2 49
39 14525759-Table2 Human Lung Singh04 53genes GeneSigDB 1.956E-4 5.938E-3 4.545E-2
2.316E-1
 2 49
40 11559565-Table3 Human Brain Rickman01 53genes GeneSigDB 2.204E-4 6.364E-3 4.871E-2
2.609E-1
 2 52
41 18308945-Table3 Human StemCell Huang08 60genes NSCs GeneSigDB 2.204E-4 6.364E-3 4.871E-2
2.609E-1
 2 52
42 17123152-Table3a Human Breast Feng07 58genesDownRegulated GeneSigDB 2.377E-4 6.702E-3
5.130E-2
2.815E-1
 2 54
43 M4737 ECM related genes up-regulated early (within 30 min) in dermal fibroblasts after addition of TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.744E-4 7.219E-3
5.525E-2
3.248E-1
 2 58
44 16203770-Table4 Human Prostate Best05 62genes GeneSigDB 2.744E-4 7.219E-3
5.525E-2
3.248E-1
 2 58
45 M17537 Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated MSigDB C2: CGP Curated Gene Sets (v6.0) 2.744E-4 7.219E-3
5.525E-2
3.248E-1
 2 58
46 12115547-Table3 Human Viral Ruutu02 63genes GeneSigDB 2.839E-4 7.308E-3
5.594E-2
3.362E-1
 2 59
47 19137020-SuppTable2a Human StemCell Fukuzawa09 114genes GeneSigDB 3.035E-4 7.646E-3
5.853E-2
3.594E-1
 2 61
48 17410534-Table1 Human Breast Klein07 63genes human Mouse GeneSigDB 3.238E-4 7.986E-3
6.113E-2
3.833E-1
 2 63
49 M1576 Selected genes down-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.341E-4 8.074E-3
6.180E-2
3.956E-1
 2 64
50 16489042-SuppTable1b Human HeadandNeck Roepman06 429genes GeneSigDB 3.496E-4 8.279E-3
6.337E-2
4.139E-1
 3 340
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 10 input genes in category / 1430 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte precursor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte precursor cell Tabula Muris Consortium 1.184E-8 1.693E-5 1.327E-4 1.693E-5 5 191
2 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Cspg5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Cspg5 Top 200 Genes BrainMap 2.262E-7 1.617E-4 1.269E-3 3.235E-4 5 345
3 Glioblastoma Single Cell Merged OPC Overall Top 200 Genes Glioblastoma Single Cell Merged OPC Overall Top 200 Genes 1.145E-6 4.092E-4 3.210E-3 1.637E-3 4 191
4 Glioblastoma Single Cell Merged OPC Top 200 Glioblastoma Single Cell Merged OPC Top 200 1.145E-6 4.092E-4 3.210E-3 1.637E-3 4 191
5 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Subtype hRgl3 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Subtype hRgl3 Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.076E-5 2.847E-3 2.233E-2 1.539E-2 4 336
6 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Subtype hRgl1 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Subtype hRgl1 Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.194E-5 2.847E-3 2.233E-2 1.708E-2 4 345
7 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.607E-5 3.009E-3 2.360E-2 2.298E-2 4 372
8 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte BrainMap 1.843E-5 3.009E-3 2.360E-2 2.636E-2 3 119
9 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k4 1000 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.136E-5 3.009E-3 2.360E-2 3.055E-2 3 125
10 gudmap dev gonad e12.5 M InterstitTestis Sma k2 500 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.402E-5 3.009E-3 2.360E-2 3.435E-2 3 130
11 gudmap dev gonad e11.5 M GonadVasMes Flk k2 100 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.559E-5 3.009E-3 2.360E-2 3.660E-2 2 17
12 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Non-keratinizing Cervical Squamous Cell Carcinoma/3/3 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Non-keratinizing Cervical Squamous Cell Carcinoma/3/3 TCGA-Cervix 4.141E-5 3.009E-3 2.360E-2
5.922E-2
 3 156
13 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.164E-5 3.009E-3 2.360E-2
7.385E-2
 3 168
14 gudmap dev gonad e11.5 M GonMes Sma k3 200 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.635E-5 3.009E-3 2.360E-2
8.058E-2
 2 25
15 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 500 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.553E-5 3.009E-3 2.360E-2
9.370E-2
 3 182
16 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 6.879E-5 3.009E-3 2.360E-2
9.837E-2
 3 185
17 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 6.879E-5 3.009E-3 2.360E-2
9.837E-2
 3 185
18 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma /Diffuse Malignant/4 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma /Diffuse Malignant/4 TCGA-Mesothelium 6.879E-5 3.009E-3 2.360E-2
9.837E-2
 3 185
19 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Polydendrocyte Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Polydendrocyte Overall Top 200 Genes 7.216E-5 3.009E-3 2.360E-2
1.032E-1
 3 188
20 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 7.216E-5 3.009E-3 2.360E-2
1.032E-1
 3 188
21 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte Polydendrocyte Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte Polydendrocyte Overall Top 200 Genes BrainMap 7.216E-5 3.009E-3 2.360E-2
1.032E-1
 3 188
22 BrainMap BrainAtlas - Human / Mouse Linnarsson Astrocyte Astrocyte Overall Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Astrocyte Astrocyte Overall Top 200 Genes BrainMap 7.330E-5 3.009E-3 2.360E-2
1.048E-1
 3 189
23 BrainMap BrainAtlas - Human / Mouse Linnarsson Astrocyte Astrocyte Top 200 BrainMap BrainAtlas - Human / Mouse Linnarsson Astrocyte Astrocyte Top 200 BrainMap 7.330E-5 3.009E-3 2.360E-2
1.048E-1
 3 189
24 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Overall Top 200 Genes BrainMap 7.330E-5 3.009E-3 2.360E-2
1.048E-1
 3 189
25 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q Polydendrocyte.polydendrocytes.Bmp4 C1q Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q Polydendrocyte.polydendrocytes.Bmp4 C1q Overall Top 200 Genes BrainMap 7.330E-5 3.009E-3 2.360E-2
1.048E-1
 3 189
26 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q Polydendrocyte.polydendrocytes.Bmp4 C1q Top 200 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q Polydendrocyte.polydendrocytes.Bmp4 C1q Top 200 BrainMap 7.330E-5 3.009E-3 2.360E-2
1.048E-1
 3 189
27 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium 7.446E-5 3.009E-3 2.360E-2
1.065E-1
 3 190
28 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/mesenchymal stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/mesenchymal stem cell Tabula Muris Consortium 7.563E-5 3.009E-3 2.360E-2
1.082E-1
 3 191
29 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Mesangium (MG) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Mesangium (MG) Fetal, Development 7.563E-5 3.009E-3 2.360E-2
1.082E-1
 3 191
30 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 TCGA-Colorectal 7.563E-5 3.009E-3 2.360E-2
1.082E-1
 3 191
31 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Bladder/bladder cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Bladder/bladder cell Tabula Muris Consortium 7.681E-5 3.009E-3 2.360E-2
1.098E-1
 3 192
32 Glioblastoma Single Cell Merged Astocyte Top 200 Glioblastoma Single Cell Merged Astocyte Top 200 7.801E-5 3.009E-3 2.360E-2
1.116E-1
 3 193
33 Glioblastoma Single Cell Merged Astocyte Overall Top 200 Genes Glioblastoma Single Cell Merged Astocyte Overall Top 200 Genes 7.801E-5 3.009E-3 2.360E-2
1.116E-1
 3 193
34 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/astrocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/astrocyte Tabula Muris Consortium 7.921E-5 3.009E-3 2.360E-2
1.133E-1
 3 194
35 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium 8.043E-5 3.009E-3 2.360E-2
1.150E-1
 3 195
36 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/5 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/5 TCGA-Esophagus 8.043E-5 3.009E-3 2.360E-2
1.150E-1
 3 195
37 Mesangium (MG) Mesangium (MG) 8.291E-5 3.009E-3 2.360E-2
1.186E-1
 3 197
38 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 8.416E-5 3.009E-3 2.360E-2
1.204E-1
 3 198
39 Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes 8.416E-5 3.009E-3 2.360E-2
1.204E-1
 3 198
40 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal RCC U U/Ureter Normal RCC U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal RCC U U/Ureter Normal RCC U21 Adult, Development, and Cancer types 8.416E-5 3.009E-3 2.360E-2
1.204E-1
 3 198
41 gudmap dev gonad e11.5 F GonadVasMes Flk k3 100 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 1.180E-4 3.991E-3 3.130E-2
1.688E-1
 2 36
42 gudmap dev gonad e11.5 F GonadVasMes Flk k1 200 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.247E-4 3.991E-3 3.130E-2
1.784E-1
 2 37
43 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRgl Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.247E-4 3.991E-3 3.130E-2
1.784E-1
 2 37
44 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 100 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 1.247E-4 3.991E-3 3.130E-2
1.784E-1
 2 37
45 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte Polydendrocyte Subtype Polydendrocyte. Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte Polydendrocyte Subtype Polydendrocyte. Top 200 Genes BrainMap 1.312E-4 3.991E-3 3.130E-2
1.876E-1
 3 230
46 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte Polydendrocyte Subtype Polydendrocyte Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte Polydendrocyte Subtype Polydendrocyte Top 200 Genes BrainMap 1.312E-4 3.991E-3 3.130E-2
1.876E-1
 3 230
47 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Polydendrocyte Subtype Polydendrocyte unk Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Polydendrocyte Subtype Polydendrocyte unk Top 200 Genes 1.312E-4 3.991E-3 3.130E-2
1.876E-1
 3 230
48 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal fetal kidney CD8 T cell/Kidney Normal fetal kidney IT2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal fetal kidney CD8 T cell/Kidney Normal fetal kidney IT2 Adult, Development, and Cancer types 1.387E-4 4.132E-3 3.241E-2
1.983E-1
 2 39
49 Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-A Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-A Lungmap CCHMC 1.543E-4 4.454E-3 3.493E-2
2.207E-1
 3 243
50 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Thalamus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Thalamus Top 200 Genes BrainMap 1.562E-4 4.454E-3 3.493E-2
2.234E-1
 3 244
Show 45 more annotations

15: Computational [Display Chart] 7 input genes in category / 51 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3849 GNF2 AF1Q Neighborhood of AF1Q MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.241E-4 3.984E-3 1.800E-2 6.331E-3 2 25
2 M19777 MODULE 385 Heparin binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.563E-4 3.984E-3 1.800E-2 7.969E-3 2 28
3 M10137 GNF2 RTN1 Neighborhood of RTN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.438E-4 9.244E-3 4.177E-2 2.773E-2 2 52
4 M18929 MODULE 12 Spinal cord (neuro-development) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.438E-3 1.582E-2
7.149E-2
7.335E-2
 3 360
5 M2707 MODULE 426 Genes in the cancer module 426. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.551E-3 1.582E-2
7.149E-2
7.910E-2
 2 88
6 M414 MODULE 122 Adhesion molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.929E-3 3.340E-2
1.509E-1
2.004E-1
 2 141
Show 1 more annotation

16: MicroRNA [Display Chart] 10 input genes in category / 255 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1914*:mirSVR highEffct hsa-miR-1914*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.317E-5 4.985E-3 3.051E-2 8.457E-3 3 477
2 hsa-miR-4666b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.909E-5 4.985E-3 3.051E-2 9.969E-3 2 68
3 hsa-miR-6818-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.223E-4 1.470E-2
8.995E-2
5.668E-2
 2 162
4 hsa-miR-4455:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.305E-4 1.470E-2
8.995E-2
5.879E-2
 2 165
5 hsa-miR-4321:mirSVR lowEffct hsa-miR-4321:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.351E-4 2.219E-2
1.358E-1
1.109E-1
 2 227
6 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 6.095E-4 2.590E-2
1.585E-1
1.554E-1
 2 269
7 hsa-miR-1280:mirSVR lowEffct hsa-miR-1280:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.158E-3 3.014E-2
1.844E-1
2.953E-1
 2 372
8 hsa-miR-1225-5p:mirSVR highEffct hsa-miR-1225-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.278E-3 3.014E-2
1.844E-1
3.258E-1
 2 391
9 hsa-miR-574-5p:Functional MTI Functional MTI miRTarbase 1.437E-3 3.014E-2
1.844E-1
3.664E-1
 2 415
10 hsa-miR-325:mirSVR highEffct hsa-miR-325:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.451E-3 3.014E-2
1.844E-1
3.699E-1
 2 417
11 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 1.745E-3 3.014E-2
1.844E-1
4.450E-1
 2 458
12 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.753E-3 3.014E-2
1.844E-1
4.469E-1
 2 459
13 hsa-miR-1470:mirSVR lowEffct hsa-miR-1470:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.768E-3 3.014E-2
1.844E-1
4.507E-1
 2 461
14 hsa-miR-508-5p:Functional MTI Functional MTI miRTarbase 1.890E-3 3.014E-2
1.844E-1
4.820E-1
 2 477
15 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 1.914E-3 3.014E-2
1.844E-1
4.880E-1
 2 480
16 hsa-miR-3165:mirSVR highEffct hsa-miR-3165:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.937E-3 3.014E-2
1.844E-1
4.940E-1
 2 483
17 hsa-miR-661:mirSVR highEffct hsa-miR-661:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.009E-3 3.014E-2
1.844E-1
5.123E-1
 2 492
Show 12 more annotations

17: Drug [Display Chart] 10 input genes in category / 5219 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000024766 chondroitin sulfate Stitch 4.658E-13 2.431E-9 2.221E-8 2.431E-9 8 413
2 CID000122591 E 14 Stitch 2.784E-12 7.266E-9 6.639E-8 1.453E-8 5 39
3 CID000032756 dermatan sulfate Stitch 1.517E-10 2.638E-7 2.411E-6 7.915E-7 6 220
4 CID000024759 hyaluronan Stitch 4.448E-10 5.804E-7 5.303E-6 2.321E-6 6 263
5 CID000082482 p-Nitrophenyl alpha-D-xyloside Stitch 1.861E-9 1.943E-6 1.775E-5 9.713E-6 4 41
6 CID000121965 2-aminoacridone Stitch 8.004E-8 6.962E-5 6.361E-4 4.177E-4 3 21
7 CID000446236 B-Ni Stitch 1.383E-7 1.031E-4 9.421E-4 7.217E-4 3 25
8 CID005459389 DB04780 Stitch 6.149E-7 3.603E-4 3.292E-3 3.209E-3 4 171
9 CID002867154 AC1MF7BR Stitch 7.928E-7 3.603E-4 3.292E-3 4.138E-3 3 44
10 CID000002683 cetylpyridinium chloride Stitch 7.928E-7 3.603E-4 3.292E-3 4.138E-3 3 44
11 CID004149241 1zd2 Stitch 8.492E-7 3.603E-4 3.292E-3 4.432E-3 3 45
12 CID000000899 N-acetylhexosamine Stitch 8.535E-7 3.603E-4 3.292E-3 4.454E-3 5 472
13 CID006453989 AC1O58I7 Stitch 1.035E-6 3.603E-4 3.292E-3 5.400E-3 2 4
14 7300 UP Nortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.061E-6 3.603E-4 3.292E-3 5.535E-3 4 196
15 6603 UP Reserpinic acid hydrochloride; Up 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.104E-6 3.603E-4 3.292E-3 5.764E-3 4 198
16 4577 DN Prednisone [53-03-2]; Down 200; 11.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.104E-6 3.603E-4 3.292E-3 5.764E-3 4 198
17 CID000001165 UDP-alpha-d-xylopyranose Stitch 2.041E-6 6.266E-4 5.725E-3 1.065E-2 3 60
18 CID000004921 proglumetacin Stitch 2.585E-6 7.102E-4 6.489E-3 1.349E-2 2 6
19 CID000126678 desproglumideproglumetacin Stitch 2.585E-6 7.102E-4 6.489E-3 1.349E-2 2 6
20 CID000014819 lead sulfide Stitch 3.265E-6 8.519E-4 7.784E-3 1.704E-2 4 260
21 CID000074493 D-galactosamine hydrochloride Stitch 4.346E-6 1.080E-3 9.869E-3 2.268E-2 3 77
22 CID005289552 alpha-D-glucose 1-phosphate 6-vanadate Stitch 6.503E-6 1.543E-3 1.410E-2 3.394E-2 3 88
23 CID000004908 primaquine Stitch 6.958E-6 1.579E-3 1.443E-2 3.632E-2 3 90
24 CID005464587 D3273 Stitch 7.932E-6 1.696E-3 1.550E-2 4.140E-2 3 94
25 CID000349960 Sialic acids Stitch 8.289E-6 1.696E-3 1.550E-2 4.326E-2 4 329
26 CID000018845 iduronic acid Stitch 8.451E-6 1.696E-3 1.550E-2 4.411E-2 3 96
27 CID016019969 thiofulminic acid Stitch 9.468E-6 1.830E-3 1.672E-2 4.942E-2 2 11
28 CID000000840 rhamnose Stitch 1.131E-5 2.044E-3 1.868E-2
5.905E-2
 4 356
29 ctd:C000873 methylprednisolone acetate CTD 1.136E-5 2.044E-3 1.868E-2
5.929E-2
 2 12
30 CID000115346 Gdrgdsp Stitch 1.238E-5 2.154E-3 1.968E-2
6.461E-2
 3 109
31 CID000107801 poly(3-hydroxybutyrate-co-3-hydroxyvalerate Stitch 1.342E-5 2.260E-3 2.065E-2
7.005E-2
 2 13
32 CID000443070 C11104 Stitch 1.566E-5 2.476E-3 2.262E-2
8.170E-2
 2 14
33 CID000134580 progesterone acetate Stitch 1.566E-5 2.476E-3 2.262E-2
8.170E-2
 2 14
34 CID000065145 DSPG Stitch 1.806E-5 2.772E-3 2.533E-2
9.425E-2
 2 15
35 CID000005742 guanidine hydrochloride Stitch 2.052E-5 3.059E-3 2.795E-2
1.071E-1
 3 129
36 CID000020796 DMSe Stitch 2.198E-5 3.186E-3 2.911E-2
1.147E-1
 3 132
37 CID000066117 adipic acid dihydrazide Stitch 2.630E-5 3.709E-3 3.389E-2
1.372E-1
 2 18
38 CID000092229 4-methylumbelliferyl-beta-D-xyloside Stitch 3.607E-5 3.843E-3 3.512E-2
1.882E-1
 2 21
39 CID000520535 superoxide Stitch 3.965E-5 3.843E-3 3.512E-2
2.069E-1
 4 490
40 CID000043187 IF-6 Stitch 3.967E-5 3.843E-3 3.512E-2
2.070E-1
 2 22
41 CID000011294 malachite green Stitch 3.967E-5 3.843E-3 3.512E-2
2.070E-1
 2 22
42 CID000060870 darglitazone Stitch 4.737E-5 3.843E-3 3.512E-2
2.472E-1
 2 24
43 ctd:D006923 Hymecromone CTD 4.737E-5 3.843E-3 3.512E-2
2.472E-1
 2 24
44 CID000060842 SKF 104353 Stitch 4.737E-5 3.843E-3 3.512E-2
2.472E-1
 2 24
45 CID000000610 glucosiduronate Stitch 4.760E-5 3.843E-3 3.512E-2
2.484E-1
 3 171
46 CID000119365 NPC 15669 Stitch 5.148E-5 3.843E-3 3.512E-2
2.687E-1
 2 25
47 CID000002299 AC1L1DD6 Stitch 5.454E-5 3.843E-3 3.512E-2
2.847E-1
 3 179
48 CID000071749 hydrotalcite Stitch 5.575E-5 3.843E-3 3.512E-2
2.910E-1
 2 26
49 CID000133909 sulfo-NHS Stitch 6.020E-5 3.843E-3 3.512E-2
3.142E-1
 2 27
50 5841 UP Podophyllotoxin [518-28-5]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.212E-5 3.843E-3 3.512E-2
3.242E-1
 3 187
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 542 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1568363 Tendinosis DisGeNET BeFree 3.611E-11 1.957E-8 1.345E-7 1.957E-8 4 12
2 C0038012 Spondylitis DisGeNET BeFree 1.538E-5 4.169E-3 2.865E-2 8.338E-3 2 10
3 C0268747 Diffuse mesangial sclerosis (disorder) DisGeNET Curated 2.664E-5 4.813E-3 3.308E-2 1.444E-2 2 13
4 C0574960 Sacroiliitis DisGeNET Curated 3.583E-5 4.856E-3 3.337E-2 1.942E-2 2 15
5 C3887486 Interstitial lung fibrosis DisGeNET BeFree 5.419E-5 5.265E-3 3.619E-2 2.937E-2 3 127
6 C0410538 Pseudoachondroplasia DisGeNET Curated 5.828E-5 5.265E-3 3.619E-2 3.159E-2 2 19
7 C0432211 Spondyloepimetaphyseal disorder DisGeNET Curated 7.153E-5 5.538E-3 3.807E-2 3.877E-2 2 21
8 C1568272 Tendinopathy DisGeNET BeFree 9.391E-5 5.712E-3 3.926E-2
5.090E-2
 2 24
9 C1442903 Exostoses DisGeNET Curated 1.020E-4 5.712E-3 3.926E-2
5.531E-2
 2 25
10 C0001080 Achondroplasia DisGeNET Curated 1.105E-4 5.712E-3 3.926E-2
5.990E-2
 2 26
11 C0022548 Keloid DisGeNET Curated 1.159E-4 5.712E-3 3.926E-2
6.283E-2
 3 164
12 C0268731 Renal glomerular disease DisGeNET Curated 1.289E-4 5.824E-3 4.003E-2
6.989E-2
 3 170
13 C0079474 Hallopeau-Siemens Disease DisGeNET Curated 1.579E-4 6.582E-3 4.524E-2
8.556E-2
 2 31
14 C0265338 Coffin-Siris syndrome DisGeNET Curated 2.135E-4 6.826E-3 4.692E-2
1.157E-1
 2 36
15 C0008479 Chondrosarcoma DisGeNET Curated 3.146E-4 6.826E-3 4.692E-2
1.705E-1
 3 230
16 C0162323 Polyarthritis DisGeNET Curated 3.198E-4 6.826E-3 4.692E-2
1.733E-1
 2 44
17 C0598935 Tumor Initiation DisGeNET BeFree 3.351E-4 6.826E-3 4.692E-2
1.816E-1
 3 235
18 C0403416 Idiopathic crescentic glomerulonephritis DisGeNET BeFree 3.651E-4 6.826E-3 4.692E-2
1.979E-1
 2 47
19 C0029434 Osteogenesis Imperfecta DisGeNET Curated 3.969E-4 6.826E-3 4.692E-2
2.151E-1
 2 49
20 C0949691 Spondylarthropathies DisGeNET BeFree 4.471E-4 6.826E-3 4.692E-2
2.423E-1
 2 52
21 C0013720 Ehlers-Danlos Syndrome DisGeNET Curated 4.471E-4 6.826E-3 4.692E-2
2.423E-1
 2 52
22 C0011389 Dental Plaque DisGeNET BeFree 6.152E-4 6.826E-3 4.692E-2
3.334E-1
 2 61
23 C4024825 Peripheral traction retinal detachment DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
24 OMIN:610048 CORNEAL DYSTROPHY, CONGENITAL STROMAL; CSCD OMIM 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
25 C3899717 Canine Melanoma DisGeNET BeFree 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
26 C0268749 Fibrillary glomerulonephritis DisGeNET BeFree 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
27 C1842149 Spondyloepiphyseal Dysplasia, Kimberley Type DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
28 cv:C2675436 Plasma fibronectin deficiency Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
29 OMIN:608361 SPONDYLOEPIPHYSEAL DYSPLASIA, KIMBERLEY TYPE OMIM 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
30 OMIN:601894 GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 OMIM 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
31 C1611195 Congenital corneal dystrophy DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
32 cv:C1864738 Congenital Stromal Corneal Dystrophy Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
33 C1288350 Subretinal membrane DisGeNET BeFree 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
34 cv:C1866075 Glomerulopathy with fibronectin deposits 2 Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
35 C3810451 Increased corneal thickness DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
36 C1864738 Corneal Dystrophy, Congenital Stromal DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
37 OMIN:612813 SPONDYLOEPIMETAPHYSEAL DYSPLASIA, AGGRECAN TYPE OMIM 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
38 cv:C0029421 Osteochondritis dissecans Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
39 C2748544 Spondyloepimetaphyseal Dysplasia, Aggrecan Type DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
40 C1610605 Graft versus host disease in skin DisGeNET BeFree 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
41 OMIN:165800 OSTEOCHONDRITIS DISSECANS, SHORT STATURE, AND EARLY-ONSET OSTEOARTHRITIS; OD OMIM 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
42 C0036413 Scleredema Adultorum DisGeNET BeFree 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
43 C1866075 GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder) DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
44 C0403557 Glomerulopathy with Giant Fibrillar Deposits DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
45 cv:C1842149 Spondyloepiphyseal dysplasia, kimberley type Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
46 cv:C2748544 Spondyloepimetaphyseal dysplasia, Aggrecan type Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
47 cv:C0339540 Wagner syndrome Clinical Variations 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
48 OMIN:143200 WAGNER SYNDROME 1; WGN1 OMIM 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
49 C4025275 Generalized distal tubular acidosis DisGeNET Curated 6.171E-4 6.826E-3 4.692E-2
3.345E-1
 1 1
50 C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 8.109E-4 8.790E-3
6.042E-2
4.395E-1
 3 318
Show 45 more annotations