Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc44_24, positive side

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1: GO: Molecular Function [Display Chart] 24 input genes in category / 33 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008017 microtubule binding 3.439E-26 6.957E-25 2.845E-24 1.135E-24 16 214
2 GO:0015631 tubulin binding 4.216E-26 6.957E-25 2.845E-24 1.391E-24 17 293
3 GO:0051011 microtubule minus-end binding 2.832E-13 3.115E-12 1.274E-11 9.345E-12 5 9
4 GO:0043015 gamma-tubulin binding 1.787E-10 1.474E-9 6.028E-9 5.897E-9 5 27
5 GO:0005200 structural constituent of cytoskeleton 2.524E-7 1.666E-6 6.812E-6 8.331E-6 5 110
6 GO:0051010 microtubule plus-end binding 3.063E-7 1.685E-6 6.889E-6 1.011E-5 3 11
7 GO:0030276 clathrin binding 3.234E-3 1.524E-2
6.233E-2
1.067E-1
 2 66
8 GO:0061676 importin-alpha family protein binding 3.854E-3 1.540E-2
6.299E-2
1.272E-1
 1 3
9 GO:0005519 cytoskeletal regulatory protein binding 5.135E-3 1.540E-2
6.299E-2
1.695E-1
 1 4
10 GO:0043515 kinetochore binding 5.135E-3 1.540E-2
6.299E-2
1.695E-1
 1 4
11 GO:0032051 clathrin light chain binding 5.135E-3 1.540E-2
6.299E-2
1.695E-1
 1 4
12 GO:0010997 anaphase-promoting complex binding 7.693E-3 2.116E-2
8.650E-2
2.539E-1
 1 6
13 GO:0003774 motor activity 1.238E-2 3.015E-2
1.233E-1
4.085E-1
 2 132
14 GO:0002162 dystroglycan binding 1.279E-2 3.015E-2
1.233E-1
4.221E-1
 1 10
15 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2.291E-2 4.770E-2
1.950E-1
7.560E-1
 1 18
16 GO:0010857 calcium-dependent protein kinase activity 2.417E-2 4.770E-2
1.950E-1
7.975E-1
 1 19
17 GO:0005516 calmodulin binding 2.457E-2 4.770E-2
1.950E-1
8.109E-1
 2 190
18 GO:0030506 ankyrin binding 2.668E-2 4.891E-2
2.000E-1
8.804E-1
 1 21
Show 13 more annotations

2: GO: Biological Process [Display Chart] 24 input genes in category / 514 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000226 microtubule cytoskeleton organization 8.978E-27 4.615E-24 3.147E-23 4.615E-24 19 464
2 GO:0007052 mitotic spindle organization 3.886E-22 9.986E-20 6.811E-19 1.997E-19 12 95
3 GO:0007051 spindle organization 6.822E-22 1.169E-19 7.972E-19 3.507E-19 13 148
4 GO:0046785 microtubule polymerization 7.179E-20 8.134E-18 5.548E-17 3.690E-17 10 58
5 GO:0031109 microtubule polymerization or depolymerization 7.912E-20 8.134E-18 5.548E-17 4.067E-17 11 95
6 GO:0090307 mitotic spindle assembly 1.813E-17 1.331E-15 9.081E-15 9.320E-15 9 58
7 GO:1902850 microtubule cytoskeleton organization involved in mitosis 1.813E-17 1.331E-15 9.081E-15 9.320E-15 9 58
8 GO:0051225 spindle assembly 1.597E-15 1.026E-13 6.996E-13 8.206E-13 9 93
9 GO:0051418 microtubule nucleation by microtubule organizing center 2.278E-15 1.171E-13 7.987E-13 1.171E-12 5 5
10 GO:0051415 microtubule nucleation by interphase microtubule organizing center 2.278E-15 1.171E-13 7.987E-13 1.171E-12 5 5
11 GO:0007020 microtubule nucleation 1.246E-13 5.822E-12 3.971E-11 6.405E-11 6 21
12 GO:0051258 protein polymerization 1.987E-13 8.509E-12 5.803E-11 1.021E-10 10 243
13 GO:0031023 microtubule organizing center organization 1.694E-12 6.697E-11 4.568E-10 8.706E-10 8 121
14 GO:0070507 regulation of microtubule cytoskeleton organization 6.577E-12 2.415E-10 1.647E-9 3.381E-9 8 143
15 GO:0031122 cytoplasmic microtubule organization 2.413E-11 8.268E-10 5.639E-9 1.240E-8 6 47
16 GO:0032886 regulation of microtubule-based process 2.782E-11 8.937E-10 6.095E-9 1.430E-8 8 171
17 GO:0000086 G2/M transition of mitotic cell cycle 8.651E-11 2.616E-9 1.784E-8 4.447E-8 8 197
18 GO:0044839 cell cycle G2/M phase transition 1.189E-10 3.337E-9 2.276E-8 6.111E-8 8 205
19 GO:0031110 regulation of microtubule polymerization or depolymerization 1.233E-10 3.337E-9 2.276E-8 6.339E-8 6 61
20 GO:0031113 regulation of microtubule polymerization 5.280E-10 1.357E-8 9.255E-8 2.714E-7 5 33
21 GO:0031111 negative regulation of microtubule polymerization or depolymerization 6.185E-10 1.514E-8 1.032E-7 3.179E-7 5 34
22 GO:0051298 centrosome duplication 1.524E-8 3.561E-7 2.429E-6 7.834E-6 5 63
23 GO:0001578 microtubule bundle formation 4.821E-8 1.077E-6 7.348E-6 2.478E-5 5 79
24 GO:0007098 centrosome cycle 5.138E-8 1.100E-6 7.505E-6 2.641E-5 5 80
25 GO:0051493 regulation of cytoskeleton organization 5.919E-8 1.217E-6 8.300E-6 3.042E-5 8 452
26 GO:1903046 meiotic cell cycle process 1.404E-7 2.775E-6 1.893E-5 7.216E-5 6 195
27 GO:0010639 negative regulation of organelle organization 1.586E-7 3.019E-6 2.059E-5 8.152E-5 7 337
28 GO:0007019 microtubule depolymerization 2.531E-7 4.646E-6 3.169E-5 1.301E-4 4 43
29 GO:0051321 meiotic cell cycle 4.430E-7 7.852E-6 5.355E-5 2.277E-4 6 237
30 GO:0007062 sister chromatid cohesion 5.220E-7 8.944E-6 6.100E-5 2.683E-4 5 127
31 GO:0051494 negative regulation of cytoskeleton organization 5.863E-7 9.720E-6 6.630E-5 3.013E-4 5 130
32 GO:0031116 positive regulation of microtubule polymerization 1.798E-6 2.888E-5 1.969E-4 9.240E-4 3 19
33 GO:0007163 establishment or maintenance of cell polarity 3.002E-6 4.676E-5 3.189E-4 1.543E-3 5 181
34 GO:0032271 regulation of protein polymerization 3.168E-6 4.790E-5 3.267E-4 1.629E-3 5 183
35 GO:0031112 positive regulation of microtubule polymerization or depolymerization 3.739E-6 5.339E-5 3.641E-4 1.922E-3 3 24
36 GO:0007026 negative regulation of microtubule depolymerization 3.739E-6 5.339E-5 3.641E-4 1.922E-3 3 24
37 GO:0031114 regulation of microtubule depolymerization 5.390E-6 7.488E-5 5.107E-4 2.770E-3 3 27
38 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 5.986E-6 8.097E-5 5.522E-4 3.077E-3 4 94
39 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 7.358E-6 9.697E-5 6.614E-4 3.782E-3 4 99
40 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 7.657E-6 9.840E-5 6.711E-4 3.936E-3 4 100
41 GO:0000819 sister chromatid segregation 8.678E-6 1.088E-4 7.420E-4 4.460E-3 5 225
42 GO:0043254 regulation of protein complex assembly 9.171E-6 1.122E-4 7.655E-4 4.714E-3 6 400
43 GO:0051261 protein depolymerization 1.078E-5 1.289E-4 8.789E-4 5.541E-3 4 109
44 GO:0098813 nuclear chromosome segregation 2.624E-5 3.065E-4 2.090E-3 1.349E-2 5 283
45 GO:0002478 antigen processing and presentation of exogenous peptide antigen 5.629E-5 6.370E-4 4.344E-3 2.893E-2 4 166
46 GO:0007059 chromosome segregation 5.701E-5 6.370E-4 4.344E-3 2.930E-2 5 333
47 GO:0019884 antigen processing and presentation of exogenous antigen 6.610E-5 7.229E-4 4.930E-3 3.397E-2 4 173
48 GO:1901880 negative regulation of protein depolymerization 8.534E-5 8.936E-4 6.095E-3 4.386E-2 3 67
49 GO:0048002 antigen processing and presentation of peptide antigen 8.574E-5 8.936E-4 6.095E-3 4.407E-2 4 185
50 GO:0031115 negative regulation of microtubule polymerization 8.693E-5 8.936E-4 6.095E-3 4.468E-2 2 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 24 input genes in category / 125 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005874 microtubule 7.458E-35 9.322E-33 5.043E-32 9.322E-33 22 426
2 GO:0005819 spindle 8.465E-18 5.291E-16 2.862E-15 1.058E-15 13 308
3 GO:0000923 equatorial microtubule organizing center 2.028E-15 8.451E-14 4.571E-13 2.535E-13 5 5
4 GO:0000922 spindle pole 3.566E-14 1.063E-12 5.751E-12 4.458E-12 9 133
5 GO:0005816 spindle pole body 4.252E-14 1.063E-12 5.751E-12 5.315E-12 5 7
6 GO:0000930 gamma-tubulin complex 7.750E-14 1.615E-12 8.734E-12 9.687E-12 6 20
7 GO:1990752 microtubule end 7.484E-13 1.336E-11 7.229E-11 9.355E-11 6 28
8 GO:0005875 microtubule associated complex 1.106E-11 1.728E-10 9.347E-10 1.382E-9 8 156
9 GO:0035371 microtubule plus-end 3.106E-11 4.313E-10 2.333E-9 3.882E-9 5 20
10 GO:0044450 microtubule organizing center part 4.358E-10 5.448E-9 2.947E-8 5.448E-8 7 147
11 GO:0032153 cell division site 8.133E-9 8.472E-8 4.583E-7 1.017E-6 5 57
12 GO:0032155 cell division site part 8.133E-9 8.472E-8 4.583E-7 1.017E-6 5 57
13 GO:0000931 gamma-tubulin large complex 9.781E-8 8.733E-7 4.724E-6 1.223E-5 3 8
14 GO:0008274 gamma-tubulin ring complex 9.781E-8 8.733E-7 4.724E-6 1.223E-5 3 8
15 GO:0005869 dynactin complex 1.466E-7 1.222E-6 6.608E-6 1.832E-5 3 9
16 GO:0000776 kinetochore 4.136E-7 3.231E-6 1.748E-5 5.170E-5 5 124
17 GO:0005876 spindle microtubule 8.991E-7 6.611E-6 3.576E-5 1.124E-4 4 60
18 GO:0005881 cytoplasmic microtubule 1.095E-6 7.608E-6 4.115E-5 1.369E-4 4 63
19 GO:0000775 chromosome, centromeric region 2.986E-6 1.964E-5 1.063E-4 3.732E-4 5 185
20 GO:0008275 gamma-tubulin small complex 4.555E-6 2.711E-5 1.467E-4 5.693E-4 2 3
21 GO:0030981 cortical microtubule cytoskeleton 4.555E-6 2.711E-5 1.467E-4 5.693E-4 2 3
22 GO:0098687 chromosomal region 5.960E-5 3.386E-4 1.832E-3 7.450E-3 5 344
23 GO:0031592 centrosomal corona 1.259E-3 6.843E-3 3.702E-2
1.574E-1
 1 1
24 GO:0030286 dynein complex 1.455E-3 7.580E-3 4.100E-2
1.819E-1
 2 45
25 GO:0044732 mitotic spindle pole body 2.517E-3 1.258E-2
6.807E-2
3.146E-1
 1 2
26 GO:0072686 mitotic spindle 2.921E-3 1.331E-2
7.203E-2
3.651E-1
 2 64
27 GO:0014069 postsynaptic density 2.983E-3 1.331E-2
7.203E-2
3.728E-1
 3 232
28 GO:0099572 postsynaptic specialization 2.983E-3 1.331E-2
7.203E-2
3.728E-1
 3 232
29 GO:0060076 excitatory synapse 3.764E-3 1.572E-2
8.504E-2
4.705E-1
 3 252
30 GO:0031523 Myb complex 3.773E-3 1.572E-2
8.504E-2
4.716E-1
 1 3
31 GO:0001750 photoreceptor outer segment 4.859E-3 1.959E-2
1.060E-1
6.073E-1
 2 83
32 GO:0000942 condensed nuclear chromosome outer kinetochore 5.027E-3 1.964E-2
1.062E-1
6.284E-1
 1 4
33 GO:0005827 polar microtubule 6.280E-3 2.304E-2
1.246E-1
7.851E-1
 1 5
34 GO:0000777 condensed chromosome kinetochore 6.317E-3 2.304E-2
1.246E-1
7.896E-1
 2 95
35 GO:0030863 cortical cytoskeleton 6.577E-3 2.304E-2
1.246E-1
8.221E-1
 2 97
36 GO:0033267 axon part 6.635E-3 2.304E-2
1.246E-1
8.294E-1
 3 309
37 GO:0005828 kinetochore microtubule 7.532E-3 2.337E-2
1.264E-1
9.415E-1
 1 6
38 GO:0044352 pinosome 7.532E-3 2.337E-2
1.264E-1
9.415E-1
 1 6
39 GO:0005818 aster 7.532E-3 2.337E-2
1.264E-1
9.415E-1
 1 6
40 GO:0044354 macropinosome 7.532E-3 2.337E-2
1.264E-1
9.415E-1
 1 6
41 GO:0000779 condensed chromosome, centromeric region 7.665E-3 2.337E-2
1.264E-1
9.582E-1
 2 105
42 GO:0045180 basal cortex 8.782E-3 2.614E-2
1.414E-1
1.000E0
 1 7
43 GO:0043203 axon hillock 1.003E-2 2.916E-2
1.577E-1
1.000E0
 1 8
44 GO:0071439 clathrin complex 1.128E-2 3.204E-2
1.733E-1
1.000E0
 1 9
45 GO:0000778 condensed nuclear chromosome kinetochore 1.252E-2 3.479E-2
1.882E-1
1.000E0
 1 10
46 GO:0044448 cell cortex part 1.294E-2 3.516E-2
1.902E-1
1.000E0
 2 138
47 GO:0036020 endolysosome membrane 1.501E-2 3.909E-2
2.114E-1
1.000E0
 1 12
48 GO:0030130 clathrin coat of trans-Golgi network vesicle 1.501E-2 3.909E-2
2.114E-1
1.000E0
 1 12
49 GO:0000940 condensed chromosome outer kinetochore 1.625E-2 4.146E-2
2.243E-1
1.000E0
 1 13
50 GO:0030136 clathrin-coated vesicle 1.753E-2 4.382E-2
2.370E-1
1.000E0
 2 162
Show 45 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 247 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008052 Retinal fold 6.067E-5 1.499E-2
9.124E-2
 1.499E-2 2 10
2 HP:0001302 Pachygyria 2.764E-4 2.788E-2
1.697E-1
6.826E-2
 3 116
3 HP:0007731 Chorioretinal dysplasia 3.386E-4 2.788E-2
1.697E-1
8.363E-2
 2 23

5: Mouse Phenotype [Display Chart] 15 input genes in category / 348 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004169 abnormal fornicate gyrus morphology 2.034E-4 4.252E-2
2.735E-1
7.079E-2
 2 15
2 MP:0008223 absent hippocampal commissure 2.957E-4 4.252E-2
2.735E-1
1.029E-1
 2 18
3 MP:0008226 decreased anterior commissure size 3.666E-4 4.252E-2
2.735E-1
1.276E-1
 2 20
4 MP:0000813 abnormal hippocampus layer morphology 5.369E-4 4.671E-2
3.004E-1
1.869E-1
 3 114

6: Domain [Display Chart] 24 input genes in category / 118 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR007259 GCP InterPro 2.211E-15 1.304E-13 6.982E-13 2.609E-13 5 5
2 PF04130 Spc97 Spc98 Pfam 2.211E-15 1.304E-13 6.982E-13 2.609E-13 5 5
3 PF03271 EB1 Pfam 4.715E-6 7.947E-5 4.254E-4 5.563E-4 2 3
4 IPR027328 MAPRE InterPro 4.715E-6 7.947E-5 4.254E-4 5.563E-4 2 3
5 PS51230 EB1 C PROSITE 4.715E-6 7.947E-5 4.254E-4 5.563E-4 2 3
6 IPR026074 MAP1 InterPro 4.715E-6 7.947E-5 4.254E-4 5.563E-4 2 3
7 IPR004953 EB1 C InterPro 4.715E-6 7.947E-5 4.254E-4 5.563E-4 2 3
8 PF12348 CLASP N Pfam 9.422E-6 1.235E-4 6.611E-4 1.112E-3 2 4
9 IPR024395 CLASP N dom InterPro 9.422E-6 1.235E-4 6.611E-4 1.112E-3 2 4
10 IPR000938 CAP-Gly domain InterPro 7.033E-5 5.533E-4 2.961E-3 8.299E-3 2 10
11 2.30.30.190 - Gene3D 7.033E-5 5.533E-4 2.961E-3 8.299E-3 2 10
12 SM01052 CAP GLY SMART 7.033E-5 5.533E-4 2.961E-3 8.299E-3 2 10
13 PS00845 CAP GLY 1 PROSITE 7.033E-5 5.533E-4 2.961E-3 8.299E-3 2 10
14 PF01302 CAP GLY Pfam 7.033E-5 5.533E-4 2.961E-3 8.299E-3 2 10
15 PS50245 CAP GLY 2 PROSITE 7.033E-5 5.533E-4 2.961E-3 8.299E-3 2 10
16 IPR021133 HEAT type 2 InterPro 2.114E-4 1.559E-3 8.344E-3 2.494E-2 2 17
17 3.60.15.10 - Gene3D 2.946E-4 1.932E-3 1.034E-2 3.477E-2 2 20
18 IPR001279 Metallo-B-lactamas InterPro 2.946E-4 1.932E-3 1.034E-2 3.477E-2 2 20
19 IPR015656 MAP1A InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
20 PF16641 CLIP1 ZNF Pfam 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
21 PF09041 Aurora-A bind Pfam 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
22 PF12455 Dynactin Pfam 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
23 IPR033702 PLK1 cat InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
24 IPR027330 TPX2 central dom InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
25 IPR027735 RP1/EB2 vertebrate InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
26 IPR027329 TPX2 C InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
27 PS00230 MAP1B NEURAXIN PROSITE 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
28 PF06886 TPX2 Pfam 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
29 IPR027323 MAP4 InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
30 PF12214 TPX2 importin Pfam 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
31 IPR030707 MAP7 InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
32 IPR017302 Doublecortin chordata InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
33 IPR027321 MAP1B InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
34 IPR032108 CLIP1 ZNF InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
35 IPR022157 Dynactin InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
36 PF00414 MAP1B neuraxin Pfam 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
37 IPR030544 CLINT1 InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
38 IPR015128 Aurora-A-bd InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
39 IPR028399 CLASP metazoan InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
40 IPR028133 Dynamitin InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
41 IPR027663 DCTN1 InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
42 IPR009675 TPX2 fam InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
43 IPR000102 MAP1B neuraxin InterPro 1.281E-3 3.515E-3 1.881E-2
1.512E-1
 1 1
44 PF02985 HEAT Pfam 1.711E-3 4.590E-3 2.456E-2
2.019E-1
 2 48
45 IPR000357 HEAT InterPro 2.488E-3 5.493E-3 2.940E-2
2.936E-1
 2 58
46 IPR029909 Arp1 InterPro 2.560E-3 5.493E-3 2.940E-2
3.021E-1
 1 2
47 IPR015348 Clathrin H-chain linker core InterPro 2.560E-3 5.493E-3 2.940E-2
3.021E-1
 1 2
48 PF01394 Clathrin propel Pfam 2.560E-3 5.493E-3 2.940E-2
3.021E-1
 1 2
49 IPR007882 MAP6 InterPro 2.560E-3 5.493E-3 2.940E-2
3.021E-1
 1 2
50 IPR016341 Clathrin heavy chain InterPro 2.560E-3 5.493E-3 2.940E-2
3.021E-1
 1 2
Show 45 more annotations

7: Pathway [Display Chart] 19 input genes in category / 124 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269806 Recruitment of mitotic centrosome proteins and complexes BioSystems: REACTOME 1.398E-22 8.665E-21 4.680E-20 1.733E-20 12 82
2 1269805 Centrosome maturation BioSystems: REACTOME 1.398E-22 8.665E-21 4.680E-20 1.733E-20 12 82
3 1269799 G2/M Transition BioSystems: REACTOME 2.629E-20 9.415E-19 5.085E-18 3.260E-18 13 184
4 1269797 Mitotic G2-G2/M phases BioSystems: REACTOME 3.037E-20 9.415E-19 5.085E-18 3.766E-18 13 186
5 1383018 AURKA Activation by TPX2 BioSystems: REACTOME 8.468E-14 2.100E-12 1.134E-11 1.050E-11 8 75
6 1269807 Recruitment of NuMA to mitotic centrosomes BioSystems: REACTOME 2.145E-12 4.433E-11 2.394E-10 2.660E-10 5 11
7 1269809 Loss of Nlp from mitotic centrosomes BioSystems: REACTOME 7.650E-12 1.186E-10 6.405E-10 9.486E-10 7 72
8 1269808 Loss of proteins required for interphase microtubule organization from the centrosome BioSystems: REACTOME 7.650E-12 1.186E-10 6.405E-10 9.486E-10 7 72
9 1269803 Regulation of PLK1 Activity at G2/M Transition BioSystems: REACTOME 3.821E-11 5.265E-10 2.844E-9 4.738E-9 7 90
10 1268847 Anchoring of the basal body to the plasma membrane BioSystems: REACTOME 8.118E-11 1.007E-9 5.437E-9 1.007E-8 7 100
11 1268846 Cilium Assembly BioSystems: REACTOME 8.012E-9 9.032E-8 4.879E-7 9.935E-7 7 192
12 1269821 Resolution of Sister Chromatid Cohesion BioSystems: REACTOME 3.727E-7 3.852E-6 2.080E-5 4.622E-5 5 103
13 1268838 Organelle biogenesis and maintenance BioSystems: REACTOME 4.127E-7 3.936E-6 2.126E-5 5.117E-5 7 341
14 1269820 Mitotic Prometaphase BioSystems: REACTOME 5.416E-7 4.797E-6 2.591E-5 6.716E-5 5 111
15 1269519 RHO GTPases Activate Formins BioSystems: REACTOME 7.041E-7 5.820E-6 3.144E-5 8.730E-5 5 117
16 1269826 Separation of Sister Chromatids BioSystems: REACTOME 4.457E-6 3.454E-5 1.866E-4 5.527E-4 5 170
17 1269825 Mitotic Anaphase BioSystems: REACTOME 6.057E-6 4.286E-5 2.315E-4 7.511E-4 5 181
18 1269823 Mitotic Metaphase and Anaphase BioSystems: REACTOME 6.222E-6 4.286E-5 2.315E-4 7.715E-4 5 182
19 137984 Lissencephaly gene (LIS1) in neuronal migration and development BioSystems: Pathway Interaction Database 1.318E-5 8.605E-5 4.648E-4 1.635E-3 3 31
20 1269200 MHC class II antigen presentation BioSystems: REACTOME 1.556E-5 9.650E-5 5.213E-4 1.930E-3 4 103
21 1269509 RHO GTPase Effectors BioSystems: REACTOME 6.390E-5 3.773E-4 2.038E-3 7.923E-3 5 295
22 1269810 M Phase BioSystems: REACTOME 8.210E-5 4.627E-4 2.500E-3 1.018E-2 5 311
23 1269507 Signaling by Rho GTPases BioSystems: REACTOME 3.738E-4 2.015E-3 1.088E-2 4.635E-2 5 430
24 1383043 COPI-independent Golgi-to-ER retrograde traffic BioSystems: REACTOME 8.146E-4 4.209E-3 2.273E-2
1.010E-1
 2 28
25 137925 Aurora A signaling BioSystems: Pathway Interaction Database 9.993E-4 4.957E-3 2.677E-2
1.239E-1
 2 31
26 137919 N-cadherin signaling events BioSystems: Pathway Interaction Database 1.133E-3 5.402E-3 2.918E-2
1.405E-1
 2 33
27 143700 Vasopressin-regulated water reabsorption BioSystems: KEGG 2.009E-3 8.898E-3 4.806E-2
2.491E-1
 2 44
28 138007 PLK1 signaling events BioSystems: Pathway Interaction Database 2.009E-3 8.898E-3 4.806E-2
2.491E-1
 2 44
29 83100 Huntington's disease BioSystems: KEGG 2.960E-3 1.220E-2
6.590E-2
3.670E-1
 3 193
30 1269824 Mitotic Metaphase/Anaphase Transition BioSystems: REACTOME 3.050E-3 1.220E-2
6.590E-2
3.782E-1
 1 2
31 1269110 Entry of Influenza Virion into Host Cell via Endocytosis BioSystems: REACTOME 3.050E-3 1.220E-2
6.590E-2
3.782E-1
 1 2
32 1269882 Golgi Associated Vesicle Biogenesis BioSystems: REACTOME 3.350E-3 1.298E-2
7.012E-2
4.154E-1
 2 57
33 1383017 The role of GTSE1 in G2/M progression after G2 checkpoint BioSystems: REACTOME 4.077E-3 1.532E-2
8.275E-2
5.055E-1
 2 63
34 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 5.436E-3 1.926E-2
1.040E-1
6.741E-1
 2 73
35 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 5.436E-3 1.926E-2
1.040E-1
6.741E-1
 2 73
36 138077 Polo-like kinase signaling events in the cell cycle BioSystems: Pathway Interaction Database 6.091E-3 2.098E-2
1.133E-1
7.553E-1
 1 4
37 1339109 COPI-mediated anterograde transport BioSystems: REACTOME 6.339E-3 2.124E-2
1.148E-1
7.860E-1
 2 79
38 1269840 Phosphorylation of Emi1 BioSystems: REACTOME 9.124E-3 2.977E-2
1.608E-1
1.000E0
 1 6
39 1270323 L1CAM interactions BioSystems: REACTOME 1.038E-2 3.217E-2
1.738E-1
1.000E0
 2 102
40 1269816 Activation of NIMA Kinases NEK9, NEK6, NEK7 BioSystems: REACTOME 1.064E-2 3.217E-2
1.738E-1
1.000E0
 1 7
41 1270328 Neurofascin interactions BioSystems: REACTOME 1.064E-2 3.217E-2
1.738E-1
1.000E0
 1 7
42 1383041 Golgi-to-ER retrograde transport BioSystems: REACTOME 1.220E-2 3.602E-2
1.946E-1
1.000E0
 2 111
43 1269892 Formation of annular gap junctions BioSystems: REACTOME 1.366E-2 3.848E-2
2.079E-1
1.000E0
 1 9
44 1270322 Role of Abl in Robo-Slit signaling BioSystems: REACTOME 1.366E-2 3.848E-2
2.079E-1
1.000E0
 1 9
45 M17370 Role of Ran in mitotic spindle regulation MSigDB C2 BIOCARTA (v6.0) 1.516E-2 4.087E-2
2.208E-1
1.000E0
 1 10
46 1269891 Gap junction degradation BioSystems: REACTOME 1.516E-2 4.087E-2
2.208E-1
1.000E0
 1 10
47 138043 Signaling mediated by p38-gamma and p38-delta BioSystems: Pathway Interaction Database 1.667E-2 4.397E-2
2.375E-1
1.000E0
 1 11
48 1268726 ER to Golgi Anterograde Transport BioSystems: REACTOME 1.744E-2 4.506E-2
2.434E-1
1.000E0
 2 134
49 1427853 VLDLR internalisation and degradation BioSystems: REACTOME 1.817E-2 4.598E-2
2.483E-1
1.000E0
 1 12
50 1269614 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 BioSystems: REACTOME 1.967E-2 4.782E-2
2.583E-1
1.000E0
 1 13
Show 45 more annotations

8: Pubmed [Display Chart] 24 input genes in category / 2726 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12221128 Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. Pubmed 6.527E-28 1.779E-24 1.510E-23 1.779E-24 12 66
2 21399614 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Pubmed 5.182E-26 7.064E-23 5.996E-22 1.413E-22 13 146
3 12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Pubmed 1.233E-17 1.121E-14 9.511E-14 3.362E-14 8 58
4 11694571 GCP5 and GCP6: two new members of the human gamma-tubulin complex. Pubmed 6.278E-17 4.278E-14 3.631E-13 1.711E-13 5 5
5 11076968 The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. Pubmed 3.350E-15 1.734E-12 1.472E-11 9.132E-12 7 56
6 16462731 The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. Pubmed 3.817E-15 1.734E-12 1.472E-11 1.041E-11 7 57
7 7790358 Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. Pubmed 6.289E-15 2.392E-12 2.030E-11 1.714E-11 7 61
8 8838651 Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis. Pubmed 7.897E-15 2.392E-12 2.030E-11 2.153E-11 5 9
9 11956313 Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. Pubmed 7.897E-15 2.392E-12 2.030E-11 2.153E-11 5 9
10 21135143 CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. Pubmed 1.579E-14 4.304E-12 3.653E-11 4.304E-11 5 10
11 20508983 Centrosome-related genes, genetic variation, and risk of breast cancer. Pubmed 2.620E-13 6.493E-11 5.511E-10 7.142E-10 7 102
12 20114047 Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Pubmed 5.524E-13 1.255E-10 1.065E-9 1.506E-9 6 51
13 21646404 SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. Pubmed 1.797E-12 3.767E-10 3.198E-9 4.897E-9 4 6
14 18614564 Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. Pubmed 5.916E-12 1.152E-9 9.778E-9 1.613E-8 7 158
15 28581483 Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Pubmed 1.056E-11 1.919E-9 1.629E-8 2.879E-8 9 495
16 17828277 Structure-function relationship of CAP-Gly domains. Pubmed 2.180E-10 3.301E-8 2.802E-7 5.943E-7 3 3
17 28039481 Phosphorylation of EB1 regulates the recruitment of CLIP-170 and p150glued to the plus ends of astral microtubules. Pubmed 2.180E-10 3.301E-8 2.802E-7 5.943E-7 3 3
18 20679239 Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Pubmed 2.180E-10 3.301E-8 2.802E-7 5.943E-7 3 3
19 30217970 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Pubmed 3.025E-10 4.339E-8 3.683E-7 8.245E-7 6 142
20 28685749 The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Pubmed 8.314E-10 1.130E-7 9.589E-7 2.266E-6 7 320
21 26950368 Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain. Pubmed 8.703E-10 1.130E-7 9.589E-7 2.372E-6 4 22
22 14514668 Characterization of functional domains of human EB1 family proteins. Pubmed 2.178E-9 2.284E-7 1.938E-6 5.938E-6 3 5
23 12388762 Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. Pubmed 2.178E-9 2.284E-7 1.938E-6 5.938E-6 3 5
24 11290329 Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Pubmed 2.178E-9 2.284E-7 1.938E-6 5.938E-6 3 5
25 10671518 A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. Pubmed 2.178E-9 2.284E-7 1.938E-6 5.938E-6 3 5
26 15631994 CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. Pubmed 2.178E-9 2.284E-7 1.938E-6 5.938E-6 3 5
27 14718566 TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Pubmed 4.354E-9 4.093E-7 3.474E-6 1.187E-5 3 6
28 11483508 Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. Pubmed 4.354E-9 4.093E-7 3.474E-6 1.187E-5 3 6
29 16455083 Microtubule binding proteins CLIP-170, EB1, and p150Glued form distinct plus-end complexes. Pubmed 4.354E-9 4.093E-7 3.474E-6 1.187E-5 3 6
30 19531213 Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. Pubmed 6.705E-9 6.093E-7 5.171E-6 1.828E-5 5 108
31 11085878 Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. Pubmed 7.617E-9 6.698E-7 5.685E-6 2.076E-5 3 7
32 18854161 ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Pubmed 1.218E-8 1.038E-6 8.809E-6 3.321E-5 3 8
33 28561026 R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Pubmed 2.670E-8 2.205E-6 1.872E-5 7.278E-5 6 300
34 23184937 Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. Pubmed 6.929E-8 5.556E-6 4.716E-5 1.889E-4 5 172
35 20562859 Network organization of the human autophagy system. Pubmed 2.322E-7 1.394E-5 1.183E-4 6.331E-4 6 433
36 15345747 Phosphoproteomic analysis of the developing mouse brain. Pubmed 3.334E-7 1.394E-5 1.183E-4 9.089E-4 5 236
37 9724749 The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
38 2355215 Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): identification of distinct genes and their differential expression in developing brain. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
39 22424550 Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
40 26972003 α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
41 23874158 Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
42 9615228 The mouse and rat MAP1B genes: genomic organization and alternative transcription. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
43 24451569 Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
44 19126680 Microtubule plus-end tracking by CLIP-170 requires EB1. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
45 21822276 MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
46 7806212 Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
47 12475954 EB1 targets to kinetochores with attached, polymerizing microtubules. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
48 23414759 The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
49 23251535 Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
50 10226031 The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. Pubmed 3.784E-7 1.394E-5 1.183E-4 1.032E-3 2 2
Show 45 more annotations

9: Interaction [Display Chart] 24 input genes in category / 1521 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DCTN1 DCTN1 interactions 6.430E-13 6.091E-10 4.815E-9 9.780E-10 10 260
2 int:MAPRE1 MAPRE1 interactions 8.009E-13 6.091E-10 4.815E-9 1.218E-9 9 174
3 int:MAPRE3 MAPRE3 interactions 8.459E-12 4.289E-9 3.390E-8 1.287E-8 6 38
4 int:CLASP1 CLASP1 interactions 2.152E-11 8.182E-9 6.468E-8 3.273E-8 6 44
5 int:PAFAH1B1 PAFAH1B1 interactions 8.208E-11 2.497E-8 1.974E-7 1.248E-7 7 108
6 int:TUBG2 TUBG2 interactions 1.226E-10 3.109E-8 2.458E-7 1.865E-7 5 24
7 int:TUBB TUBB interactions 2.700E-10 5.373E-8 4.247E-7 4.107E-7 9 333
8 int:TUBGCP5 TUBGCP5 interactions 2.826E-10 5.373E-8 4.247E-7 4.298E-7 5 28
9 int:TUBGCP6 TUBGCP6 interactions 3.411E-10 5.765E-8 4.557E-7 5.189E-7 5 29
10 int:TXNDC12 TXNDC12 interactions 4.090E-10 6.221E-8 4.918E-7 6.221E-7 5 30
11 int:MZT2B MZT2B interactions 4.872E-10 6.737E-8 5.325E-7 7.411E-7 5 31
12 int:CLIP1 CLIP1 interactions 1.639E-9 2.078E-7 1.642E-6 2.493E-6 5 39
13 int:SCAF11 SCAF11 interactions 4.836E-9 5.658E-7 4.472E-6 7.355E-6 5 48
14 int:MZT1 MZT1 interactions 8.068E-9 8.766E-7 6.929E-6 1.227E-5 5 53
15 int:ZNF598 ZNF598 interactions 1.403E-8 1.423E-6 1.125E-5 2.135E-5 8 357
16 int:MZT2A MZT2A interactions 1.531E-8 1.455E-6 1.150E-5 2.328E-5 4 21
17 int:NEDD1 NEDD1 interactions 2.985E-8 2.671E-6 2.111E-5 4.541E-5 6 143
18 int:CDK5RAP2 CDK5RAP2 interactions 3.602E-8 3.044E-6 2.406E-5 5.479E-5 5 71
19 int:CNTRL CNTRL interactions 5.837E-8 4.673E-6 3.693E-5 8.878E-5 6 160
20 int:BICD2 BICD2 interactions 9.107E-8 6.926E-6 5.474E-5 1.385E-4 4 32
21 int:KCNMA1 KCNMA1 interactions 1.670E-7 1.204E-5 9.519E-5 2.539E-4 6 191
22 int:TUBGCP2 TUBGCP2 interactions 1.742E-7 1.204E-5 9.519E-5 2.649E-4 5 97
23 int:TUBGCP4 TUBGCP4 interactions 2.717E-7 1.797E-5 1.420E-4 4.133E-4 5 106
24 int:NINL NINL interactions 3.740E-7 2.370E-5 1.873E-4 5.688E-4 6 219
25 int:SH3KBP1 SH3KBP1 interactions 4.499E-7 2.737E-5 2.164E-4 6.843E-4 6 226
26 int:NIN NIN interactions 6.182E-7 3.504E-5 2.770E-4 9.403E-4 5 125
27 int:CLASP2 CLASP2 interactions 6.221E-7 3.504E-5 2.770E-4 9.462E-4 4 51
28 int:MAPRE2 MAPRE2 interactions 7.276E-7 3.907E-5 3.088E-4 1.107E-3 4 53
29 int:BTRC BTRC interactions 7.449E-7 3.907E-5 3.088E-4 1.133E-3 7 403
30 int:TUBG1 TUBG1 interactions 8.315E-7 4.216E-5 3.332E-4 1.265E-3 6 251
31 int:CD2BP2 CD2BP2 interactions 1.334E-6 6.547E-5 5.175E-4 2.029E-3 5 146
32 int:GTSE1 GTSE1 interactions 1.380E-6 6.560E-5 5.185E-4 2.099E-3 5 147
33 int:TUBGCP3 TUBGCP3 interactions 1.736E-6 8.001E-5 6.325E-4 2.640E-3 5 154
34 int:TUBA1A TUBA1A interactions 2.086E-6 9.332E-5 7.377E-4 3.173E-3 6 294
35 int:SEC16A SEC16A interactions 2.161E-6 9.390E-5 7.422E-4 3.286E-3 5 161
36 int:NME7 NME7 interactions 2.244E-6 9.479E-5 7.493E-4 3.412E-3 4 70
37 int:LGALS3BP LGALS3BP interactions 2.823E-6 1.147E-4 9.066E-4 4.293E-3 5 170
38 int:PDGFD PDGFD interactions 2.865E-6 1.147E-4 9.066E-4 4.358E-3 3 21
39 int:BICD1 BICD1 interactions 3.315E-6 1.272E-4 1.006E-3 5.042E-3 3 22
40 int:AURKB AURKB interactions 3.346E-6 1.272E-4 1.006E-3 5.089E-3 5 176
41 int:ACTR1A ACTR1A interactions 3.647E-6 1.353E-4 1.069E-3 5.546E-3 4 79
42 int:DYNC1H1 DYNC1H1 interactions 4.385E-6 1.572E-4 1.243E-3 6.670E-3 5 186
43 int:SPAG5 SPAG5 interactions 4.444E-6 1.572E-4 1.243E-3 6.759E-3 4 83
44 int:INAVA INAVA interactions 4.938E-6 1.707E-4 1.349E-3 7.510E-3 3 25
45 int:DCTN5 DCTN5 interactions 5.577E-6 1.885E-4 1.490E-3 8.482E-3 3 26
46 int:MAP1LC3B MAP1LC3B interactions 9.338E-6 3.088E-4 2.441E-3 1.420E-2 4 100
47 int:DCTN6 DCTN6 interactions 1.938E-5 6.271E-4 4.957E-3 2.947E-2 3 39
48 int:MAP1LC3A MAP1LC3A interactions 2.402E-5 7.535E-4 5.956E-3 3.653E-2 4 127
49 int:GGA2 GGA2 interactions 2.428E-5 7.535E-4 5.956E-3 3.692E-2 3 42
50 int:CAPZA2 CAPZA2 interactions 2.618E-5 7.965E-4 6.296E-3 3.983E-2 5 269
Show 45 more annotations

10: Cytoband [Display Chart] 24 input genes in category / 24 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22q13.31-q13.33 22q13.31-q13.33 1.384E-3 1.246E-2 4.703E-2 3.323E-2 1 2
2 2q14.2-q14.3 2q14.2-q14.3 1.384E-3 1.246E-2 4.703E-2 3.323E-2 1 2
3 Xq22.3-q23 Xq22.3-q23 2.076E-3 1.246E-2 4.703E-2 4.982E-2 1 3
4 20q11.1-q11.23 20q11.1-q11.23 2.076E-3 1.246E-2 4.703E-2 4.982E-2 1 3
5 12q24.3 12q24.3 4.148E-3 1.991E-2
7.517E-2
9.954E-2
 1 6
6 15q15 15q15 8.279E-3 3.074E-2
1.161E-1
1.987E-1
 1 12
7 17q11 17q11 8.966E-3 3.074E-2
1.161E-1
2.152E-1
 1 13
8 5q13 5q13 1.513E-2 3.183E-2
1.202E-1
3.631E-1
 1 22
9 11q13.5 11q13.5 1.581E-2 3.183E-2
1.202E-1
3.794E-1
 1 23
10 2p13 2p13 1.649E-2 3.183E-2
1.202E-1
3.958E-1
 1 24
11 15q15.3 15q15.3 1.785E-2 3.183E-2
1.202E-1
4.285E-1
 1 26
12 10q24.32 10q24.32 1.785E-2 3.183E-2
1.202E-1
4.285E-1
 1 26
13 20q11.2 20q11.2 1.853E-2 3.183E-2
1.202E-1
4.448E-1
 1 27
14 6q23.3 6q23.3 1.989E-2 3.183E-2
1.202E-1
4.775E-1
 1 29
15 18q12.1 18q12.1 1.989E-2 3.183E-2
1.202E-1
4.775E-1
 1 29
16 3p21 3p21 2.329E-2 3.375E-2
1.275E-1
5.589E-1
 1 34
17 5q33.3 5q33.3 2.464E-2 3.375E-2
1.275E-1
5.914E-1
 1 36
18 16p12.2 16p12.2 2.532E-2 3.375E-2
1.275E-1
6.076E-1
 1 37
19 12q13.3 12q13.3 3.540E-2 4.409E-2
1.665E-1
8.497E-1
 1 52
20 10q26.3 10q26.3 3.674E-2 4.409E-2
1.665E-1
8.818E-1
 1 54
21 13q34 13q34 4.074E-2 4.656E-2
1.758E-1
9.778E-1
 1 60
Show 16 more annotations

11: Transcription Factor Binding Site [Display Chart] 18 input genes in category / 268 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$ER Q6 02 V$ER Q6 02 5.100E-4 4.654E-2
2.871E-1
1.367E-1
 4 211
2 V$PAX4 03 V$PAX4 03 5.285E-4 4.654E-2
2.871E-1
1.416E-1
 4 213
3 V$NFE2 01 V$NFE2 01 6.075E-4 4.654E-2
2.871E-1
1.628E-1
 4 221
4 V$AP1 Q2 V$AP1 Q2 6.946E-4 4.654E-2
2.871E-1
1.862E-1
 4 229

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 943 Dynactin genenames.org 9.059E-7 3.624E-6 7.549E-6 3.624E-6 2 6
2 1138 Stathmins genenames.org 1.099E-3 2.198E-3 4.579E-3 4.396E-3 1 4
3 1369 Doublecortin superfamily genenames.org 3.020E-3 4.026E-3 8.388E-3 1.208E-2 1 11
4 694 Protein phosphatase 1 regulatory subunits genenames.org 4.877E-2 4.877E-2
1.016E-1
1.951E-1
 1 181

13: Coexpression [Display Chart] 24 input genes in category / 2290 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5893 Genes important for mitotic spindle assembly. MSigDB H: Hallmark Gene Sets (v6.0) 3.279E-15 7.509E-12 6.243E-11 7.509E-12 10 200
2 M2969 Genes down-regulated in T reg: induced versus natural. MSigDB C7: Immunologic Signatures (v6.0) 9.617E-7 1.101E-3 9.155E-3 2.202E-3 5 178
3 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.670E-6 2.184E-3 1.816E-2 8.403E-3 6 423
4 18271932-GeneList Human Breast Takahashi08 33genes TP53 GeneSigDB 3.909E-6 2.184E-3 1.816E-2 8.951E-3 3 30
5 M1595 Up-regulated genes in non-neoplastic mucosa samples from colon cancer patients who developed recurrence of the disease. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.769E-6 2.184E-3 1.816E-2 1.092E-2 3 32
6 15896717-Table7 Human Leukemia Bal05 36genes GeneSigDB 6.846E-6 2.613E-3 2.172E-2 1.568E-2 3 36
7 M1470 Cluster 5: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.446E-5 4.417E-3 3.672E-2 3.310E-2 3 46
8 16513838-Table1 Human HeadandNeck Cloos06 52genes ExposureToBleomycin GeneSigDB 1.543E-5 4.417E-3 3.672E-2 3.534E-2 3 47
9 M8235 Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.153E-5 5.478E-3 4.555E-2 4.930E-2 4 161
10 16091735-Table1 Human Colon Barrier05 70genes GeneSigDB 3.069E-5 6.178E-3
5.136E-2
7.027E-2
 3 59
11 17899371-GeneTable4 Human Breast Lauss08 374genes GeneSigDB 3.116E-5 6.178E-3
5.136E-2
7.135E-2
 5 364
12 M8580 Genes up-regulated in T helper cells 15 days post polarization and stimulated with anti-CD3 and anti-CD28: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v6.0) 4.834E-5 6.178E-3
5.136E-2
1.107E-1
 4 198
13 M8299 Genes down-regulated in thymocytes: double positive versus CD4 [GeneID=920] single positive. MSigDB C7: Immunologic Signatures (v6.0) 4.930E-5 6.178E-3
5.136E-2
1.129E-1
 4 199
14 M4622 Genes up-regulated in comparison of untreated CD25+ T effector cells at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v6.0) 5.027E-5 6.178E-3
5.136E-2
1.151E-1
 4 200
15 M8855 Genes up-regulated in lymphoid primed multipotent progenitors versus pro-B cells. MSigDB C7: Immunologic Signatures (v6.0) 5.027E-5 6.178E-3
5.136E-2
1.151E-1
 4 200
16 M5303 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 5.027E-5 6.178E-3
5.136E-2
1.151E-1
 4 200
17 M9037 Genes down-regulated in macrophages with knockout of HDAC3 [GeneID=8841]: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 5.027E-5 6.178E-3
5.136E-2
1.151E-1
 4 200
18 M3580 Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those from mice defficient for TRAF6 [GeneID=7189] at day 10. MSigDB C7: Immunologic Signatures (v6.0) 5.027E-5 6.178E-3
5.136E-2
1.151E-1
 4 200
19 16513838-TableS1 Human HeadandNeck Cloos06 52genes GeneListBleoComparison GeneSigDB 5.126E-5 6.178E-3
5.136E-2
1.174E-1
 4 201
20 M10739 Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing a constantly active form of NRAS [GeneID=4893] off a plasmid vector compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.580E-5 6.389E-3
5.312E-2
1.278E-1
 3 72
21 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.189E-4 1.216E-2
1.011E-1
2.722E-1
 5 483
22 M3898 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.212E-4 1.216E-2
1.011E-1
2.775E-1
 5 485
23 15467184-Table1b Human Stomach Lee04 16genes GeneSigDB 1.227E-4 1.216E-2
1.011E-1
2.809E-1
 2 16
24 12874028-Table1 Human Esophagus Barrett03 104genes GeneSigDB 1.275E-4 1.216E-2
1.011E-1
2.920E-1
 3 95
25 M18506 Genes down-regulated in the ANBL-6 cell line (multiple myeloma, MM) after withdrawal of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.398E-4 1.281E-2
1.065E-1
3.202E-1
 3 98
26 17234769-TableS2a Human StemCell West07 350genes GeneSigDB 2.080E-4 1.788E-2
1.486E-1
4.763E-1
 4 289
27 M14985 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.108E-4 1.788E-2
1.486E-1
4.827E-1
 4 290
28 M1918 Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.192E-4 1.793E-2
1.491E-1
5.020E-1
 4 293
29 M9402 Cell cycle genes down-regulated in H1299 cells (lung cancer) after overexpression of either P53 or P73 [GeneID=7157;7161]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.352E-4 1.795E-2
1.493E-1
5.386E-1
 2 22
30 M2355 Proteins associated with ZNF143 [GeneID=7702] in HeLa cells, based on MudPIT analysis. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.352E-4 1.795E-2
1.493E-1
5.386E-1
 2 22
31 15073113-Table4 Human Testicular Sugimura04 30genes NeuroectodermalTumor GeneSigDB 3.563E-4 2.632E-2
2.188E-1
8.158E-1
 2 27
32 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.945E-4 2.750E-2
2.286E-1
9.034E-1
 4 342
33 18662380-S3-AURKA Human Breast Wirapati08 355genes AURKA Module GeneSigDB 4.033E-4 2.750E-2
2.286E-1
9.235E-1
 4 344
34 18427120-DataS5 Human Breast Crawford08 187genes GeneSigDB 4.082E-4 2.750E-2
2.286E-1
9.349E-1
 3 141
35 15358818-table1 Human Stomach Yuan04 32genes GeneSigDB 4.407E-4 2.804E-2
2.331E-1
1.000E0
 2 30
36 17982488-Table1 Human Colon Scian08 31genes CellCyle GeneSigDB 4.708E-4 2.804E-2
2.331E-1
1.000E0
 2 31
37 M3766 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.987E-4 2.804E-2
2.331E-1
1.000E0
 3 151
38 M438 Genes up-regulated in CAL1 cells (plasmacytoid dendritic cells) versus MOLT4 (immature T cells). MSigDB C7: Immunologic Signatures (v6.0) 4.987E-4 2.804E-2
2.331E-1
1.000E0
 3 151
39 M13108 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.232E-4 2.804E-2
2.331E-1
1.000E0
 3 163
40 M3000 Genes up-regulated in B lymphocytes with ZFX [GeneID=7543] knockout: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v6.0) 6.232E-4 2.804E-2
2.331E-1
1.000E0
 3 163
41 20436685-ST6-2 Human Breast Pothuri10 180genes GeneSigDB 6.686E-4 2.804E-2
2.331E-1
1.000E0
 3 167
42 19043454-TableS2 Human Breast Thorner09 217genes GeneSigDB 6.686E-4 2.804E-2
2.331E-1
1.000E0
 3 167
43 M1726 Transcripts showing subcellular localization only to proximal dendrites in the adult mouse brain. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.717E-4 2.804E-2
2.331E-1
1.000E0
 2 37
44 M6499 Genes down-regulated in monocyte-derived dendritic cells: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 6.922E-4 2.804E-2
2.331E-1
1.000E0
 3 169
45 19185848-Table1 Mouse StemCell Read09 41genes GeneSigDB 7.464E-4 2.804E-2
2.331E-1
1.000E0
 2 39
46 M8127 Genes up-regulated in AGS cells (gastric adenocarcinoma): control versus H. pylori LPS. MSigDB C7: Immunologic Signatures (v6.0) 7.659E-4 2.804E-2
2.331E-1
1.000E0
 3 175
47 M2115 Genes correlated with proneural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.915E-4 2.804E-2
2.331E-1
1.000E0
 3 177
48 M2959 Genes up-regulated in induced T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 8.045E-4 2.804E-2
2.331E-1
1.000E0
 3 178
49 M2993 Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v6.0) 8.310E-4 2.804E-2
2.331E-1
1.000E0
 3 180
50 M2961 Genes down-regulated in natural T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 8.310E-4 2.804E-2
2.331E-1
1.000E0
 3 180
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 24 input genes in category / 1624 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 7.623E-7 6.521E-4 5.197E-3 1.238E-3 7 498
2 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRN Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRN Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 1.504E-6 6.521E-4 5.197E-3 2.442E-3 5 184
3 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRN Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hRN Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.504E-6 6.521E-4 5.197E-3 2.442E-3 5 184
4 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbML1 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbML1 Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.606E-6 6.521E-4 5.197E-3 2.608E-3 6 346
5 gudmap developingLowerUrinaryTract P1 bladder J 500 k5 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.144E-6 1.624E-3 1.295E-2 8.353E-3 3 31
6 gudmap developingGonad e11.5 ovary + mesonephros k3 1000 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.001E-6 1.624E-3 1.295E-2 9.745E-3 4 110
7 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 1.240E-5 2.662E-3 2.122E-2 2.014E-2 6 494
8 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type A/3/5 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type A/3/5 TCGA-Thymus 1.311E-5 2.662E-3 2.122E-2 2.130E-2 4 134
9 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 200 k3 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.834E-5 3.310E-3 2.638E-2 2.979E-2 3 47
10 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k5 200 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.081E-5 3.380E-3 2.694E-2 3.380E-2 3 49
11 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbML5 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbML5 Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.763E-5 4.079E-3 3.251E-2 4.487E-2 5 335
12 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb3 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb3 Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 3.269E-5 4.424E-3 3.526E-2
5.309E-2
 5 347
13 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.454E-5 4.618E-3 3.681E-2
7.234E-2
 4 183
14 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 4.454E-5 4.618E-3 3.681E-2
7.234E-2
 4 183
15 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Overall Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 4.550E-5 4.618E-3 3.681E-2
7.389E-2
 4 184
16 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.550E-5 4.618E-3 3.681E-2
7.389E-2
 4 184
17 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 1000 k3 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.192E-5 6.871E-3
5.476E-2
1.168E-1
 4 207
18 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.368E-5 7.550E-3
6.017E-2
1.359E-1
 5 423
19 Lungmap Mouse Lung PND1 Endothelial Subtype Primitive Proliferative Endothelial Lungmap Mouse Lung PND1 Endothelial Subtype Primitive Proliferative Endothelial Lungmap CCHMC 9.105E-5 7.647E-3
6.095E-2
1.479E-1
 4 220
20 GSM605781 100 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 9.417E-5 7.647E-3
6.095E-2
1.529E-1
 3 81
21 GSM538348 100 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.013E-4 7.749E-3
6.176E-2
1.645E-1
 3 83
22 GSM538350 100 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.165E-4 7.749E-3
6.176E-2
1.892E-1
 3 87
23 GSM476658 100 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 1.165E-4 7.749E-3
6.176E-2
1.892E-1
 3 87
24 GSM538357 100 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.205E-4 7.749E-3
6.176E-2
1.957E-1
 3 88
25 GSM538355 100 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.246E-4 7.749E-3
6.176E-2
2.024E-1
 3 89
26 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 100 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.246E-4 7.749E-3
6.176E-2
2.024E-1
 3 89
27 gudmap developingLowerUrinaryTract P1 bladder J 1000 k4 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.288E-4 7.749E-3
6.176E-2
2.092E-1
 3 90
28 facebase RNAseq e8.5 NeuroEpith hindBrain 2500 K2 facebase RNAseq e8.5 NeuroEpith hindBrain 2500 K2 Gudmap RNAseq 1.512E-4 8.160E-3
6.503E-2
2.456E-1
 3 95
29 6mo cortical organoids wt 6mo cortical organoids wt Subtype mature neuron 1 Top 100 6mo cortical organoids wt 6mo cortical organoids wt Subtype mature neuron 1 Top 100 1.529E-4 8.160E-3
6.503E-2
2.483E-1
 5 481
30 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 500 k1 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.560E-4 8.160E-3
6.503E-2
2.534E-1
 3 96
31 6mo cortical organoids wt 6mo cortical organoids wt Subtype 2 static Subtype 2 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype 2 static Subtype 2 Top 100 Genes 1.560E-4 8.160E-3
6.503E-2
2.534E-1
 3 96
32 Lungmap Mouse Lung PND3 MatrixFB Subtype MatrixFB-B Lungmap Mouse Lung PND3 MatrixFB Subtype MatrixFB-B Lungmap CCHMC 1.608E-4 8.160E-3
6.503E-2
2.611E-1
 4 255
33 6mo cortical organoids wt 6mo cortical organoids wt pan subtypes immature neuro precursors Overall Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt pan subtypes immature neuro precursors Overall Top 100 Genes 1.658E-4 8.161E-3
6.504E-2
2.693E-1
 3 98
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma/Kidney Normal fetal kidney T10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma/Kidney Normal fetal kidney T10 Adult, Development, and Cancer types 2.402E-4 1.147E-2
9.144E-2
3.901E-1
 2 21
35 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D Lungmap CCHMC 2.915E-4 1.291E-2
1.029E-1
4.735E-1
 4 298
36 Facebase RNAseq e10.5 Neural Epithelium Overlying Central Eminence 1000 K4 FacebaseRNAseq e10.5 Neural Epithelium Overlying Central Eminence top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 2.915E-4 1.291E-2
1.029E-1
4.735E-1
 4 298
37 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s7 immature neuro precursors Subtype immature neuro precursors s7 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s7 immature neuro precursors Subtype immature neuro precursors s7 Top 100 Genes 2.941E-4 1.291E-2
1.029E-1
4.776E-1
 3 119
38 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb1 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb1 Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 3.106E-4 1.317E-2
1.050E-1
5.044E-1
 4 303
39 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s6 immature neuro precursors Subtype immature neuro precursors s6 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s6 immature neuro precursors Subtype immature neuro precursors s6 Top 100 Genes 3.164E-4 1.317E-2
1.050E-1
5.138E-1
 3 122
40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkF Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkF Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.513E-4 1.426E-2
1.137E-1
5.705E-1
 4 313
41 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbM Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNbM Subtype hNbM Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.686E-4 1.433E-2
1.142E-1
5.986E-1
 4 317
42 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k5 100 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.705E-4 1.433E-2
1.142E-1
6.017E-1
 2 26
43 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb2 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb2 Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 4.291E-4 1.605E-2
1.279E-1
6.968E-1
 4 330
44 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k2 1000 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.540E-4 1.605E-2
1.279E-1
7.372E-1
 3 138
45 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb4 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb4 Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 4.593E-4 1.605E-2
1.279E-1
7.459E-1
 4 336
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour RCC EN-U/Kidney Tumour RCC EN15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour RCC EN-U/Kidney Tumour RCC EN15 Adult, Development, and Cancer types 4.619E-4 1.605E-2
1.279E-1
7.501E-1
 2 29
47 GSM777024 500 B cells, B.Pl.AA4+220+.BM, CD138+ AA4.1+ CD43- CD45R+, Bone marrow, avg-3 Immgen.org, GSE15907 4.644E-4 1.605E-2
1.279E-1
7.543E-1
 4 337
48 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Subtype iProg1 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Subtype iProg1 Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 4.964E-4 1.679E-2
1.339E-1
8.061E-1
 4 343
49 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hGaba Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hGaba Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 5.299E-4 1.756E-2
1.400E-1
8.605E-1
 4 349
50 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes 5.790E-4 1.881E-2
1.499E-1
9.403E-1
 3 150
Show 45 more annotations

15: Computational [Display Chart] 20 input genes in category / 166 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8466 MODULE 253 Intracellular transport (MT cytoskeleton and motors). MSigDb: C4 - CM: Cancer Modules (v6.0) 6.714E-8 8.224E-6 4.681E-5 1.115E-5 4 21
2 M2815 MODULE 196 Genes in the cancer module 196. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.908E-8 8.224E-6 4.681E-5 1.645E-5 4 23
3 M5260 MODULE 72 Testis genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.922E-4 1.617E-2
9.204E-2
 4.851E-2 5 311
4 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.260E-4 2.354E-2
1.340E-1
1.039E-1
 5 367
5 M9199 MODULE 3 Genes in the cancer module 3. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.784E-4 2.354E-2
1.340E-1
1.292E-1
 5 385
6 M375 MODULE 222 Genes in the cancer module 222. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.508E-4 2.354E-2
1.340E-1
1.412E-1
 2 22
7 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.165E-3 2.742E-2
1.561E-1
1.934E-1
 5 421
8 M10190 MODULE 52 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.322E-3 2.742E-2
1.561E-1
2.194E-1
 5 433
9 M15619 MODULE 18 Genes in the cancer module 18. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.585E-3 2.923E-2
1.664E-1
2.631E-1
 5 451
10 M2127 GCM FANCC Neighborhood of FANCC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.799E-3 2.987E-2
1.700E-1
2.987E-1
 3 124
11 M664 GNF2 ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.158E-3 3.256E-2
1.854E-1
3.582E-1
 2 35
Show 6 more annotations

16: MicroRNA [Display Chart] 24 input genes in category / 1010 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-199a-5p:PITA hsa-miR-199a-5p:PITA TOP PITA 1.621E-6 8.187E-4 6.136E-3 1.637E-3 4 259
2 hsa-miR-199b-5p:PITA hsa-miR-199b-5p:PITA TOP PITA 1.621E-6 8.187E-4 6.136E-3 1.637E-3 4 259
3 hsa-miR-6809-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.413E-6 1.017E-3 7.620E-3 5.467E-3 3 102
4 hsa-miR-504:PITA hsa-miR-504:PITA TOP PITA 5.738E-6 1.017E-3 7.620E-3 5.796E-3 3 104
5 hsa-miR-6758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.428E-6 1.017E-3 7.620E-3 6.492E-3 3 108
6 hsa-miR-583:PITA hsa-miR-583:PITA TOP PITA 7.217E-6 1.017E-3 7.620E-3 7.289E-3 4 378
7 hsa-miR-210-3p:Functional MTI Functional MTI miRTarbase 9.497E-6 1.017E-3 7.620E-3 9.592E-3 3 123
8 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 1.102E-5 1.017E-3 7.620E-3 1.113E-2 4 421
9 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 1.102E-5 1.017E-3 7.620E-3 1.113E-2 4 421
10 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 1.102E-5 1.017E-3 7.620E-3 1.113E-2 4 421
11 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 1.208E-5 1.017E-3 7.620E-3 1.220E-2 4 431
12 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 1.208E-5 1.017E-3 7.620E-3 1.220E-2 4 431
13 ACCAAAG,MIR-9:MSigDB ACCAAAG,MIR-9:MSigDB MSigDB 1.709E-5 1.328E-3 9.955E-3 1.727E-2 4 471
14 hsa-miR-99a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.550E-5 3.871E-3 2.902E-2
5.605E-2
 2 33
15 TAGCTTT,MIR-9:MSigDB TAGCTTT,MIR-9:MSigDB MSigDB 5.749E-5 3.871E-3 2.902E-2
5.807E-2
 3 225
16 hsa-miR-409-3p:TargetScan hsa-miR-409-3p TargetScan 6.215E-5 3.923E-3 2.941E-2
6.278E-2
 3 231
17 hsa-miR-433-3p:TargetScan hsa-miR-433-3p TargetScan 6.706E-5 3.984E-3 2.986E-2
6.773E-2
 3 237
18 hsa-miR-4766-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.382E-5 4.142E-3 3.105E-2
7.456E-2
 2 38
19 hsa-miR-542-3p:TargetScan hsa-miR-542-3p TargetScan 8.621E-5 4.250E-3 3.186E-2
8.707E-2
 3 258
20 CACTGCC,MIR-34A:MSigDB CACTGCC,MIR-34A:MSigDB MSigDB 9.540E-5 4.250E-3 3.186E-2
9.635E-2
 3 267
21 CACTGCC,MIR-449:MSigDB CACTGCC,MIR-449:MSigDB MSigDB 9.540E-5 4.250E-3 3.186E-2
9.635E-2
 3 267
22 CACTGCC,MIR-34C:MSigDB CACTGCC,MIR-34C:MSigDB MSigDB 9.540E-5 4.250E-3 3.186E-2
9.635E-2
 3 267
23 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 9.752E-5 4.250E-3 3.186E-2
9.850E-2
 3 269
24 hsa-miR-302f:PITA hsa-miR-302f:PITA TOP PITA 1.019E-4 4.250E-3 3.186E-2
1.029E-1
 3 273
25 hsa-miR-1207-3p:PITA hsa-miR-1207-3p:PITA TOP PITA 1.052E-4 4.250E-3 3.186E-2
1.063E-1
 3 276
26 hsa-miR-34a:PITA hsa-miR-34a:PITA TOP PITA 1.280E-4 4.459E-3 3.342E-2
1.293E-1
 3 295
27 hsa-miR-449a:PITA hsa-miR-449a:PITA TOP PITA 1.280E-4 4.459E-3 3.342E-2
1.293E-1
 3 295
28 hsa-miR-34c-5p:PITA hsa-miR-34c-5p:PITA TOP PITA 1.280E-4 4.459E-3 3.342E-2
1.293E-1
 3 295
29 hsa-miR-449b:PITA hsa-miR-449b:PITA TOP PITA 1.280E-4 4.459E-3 3.342E-2
1.293E-1
 3 295
30 hsa-miR-487a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.498E-4 5.042E-3 3.779E-2
1.513E-1
 2 54
31 hsa-miR-488:PITA hsa-miR-488:PITA TOP PITA 1.718E-4 5.596E-3 4.195E-2
1.735E-1
 3 326
32 hsa-miR-4708-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.106E-4 6.476E-3 4.854E-2
2.127E-1
 2 64
33 hsa-miR-9-5p:Functional MTI Functional MTI miRTarbase 2.116E-4 6.476E-3 4.854E-2
2.137E-1
 3 350
34 hsa-miR-922:PITA hsa-miR-922:PITA TOP PITA 2.818E-4 8.372E-3
6.276E-2
2.847E-1
 3 386
35 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 3.015E-4 8.458E-3
6.340E-2
3.045E-1
 3 395
36 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 3.015E-4 8.458E-3
6.340E-2
3.045E-1
 3 395
37 hsa-miR-339-5p:PITA hsa-miR-339-5p:PITA TOP PITA 3.456E-4 8.962E-3
6.718E-2
3.491E-1
 2 82
38 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 3.606E-4 8.962E-3
6.718E-2
3.642E-1
 3 420
39 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 3.657E-4 8.962E-3
6.718E-2
3.693E-1
 3 422
40 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 3.657E-4 8.962E-3
6.718E-2
3.693E-1
 3 422
41 hsa-miR-645:PITA hsa-miR-645:PITA TOP PITA 3.713E-4 8.962E-3
6.718E-2
3.750E-1
 2 85
42 hsa-miR-576-5p:PITA hsa-miR-576-5p:PITA TOP PITA 3.968E-4 8.962E-3
6.718E-2
4.008E-1
 3 434
43 hsa-miR-877-5p:TargetScan hsa-miR-877-5p TargetScan 4.070E-4 8.962E-3
6.718E-2
4.110E-1
 2 89
44 hsa-miR-571:PITA hsa-miR-571:PITA TOP PITA 4.348E-4 8.962E-3
6.718E-2
4.391E-1
 2 92
45 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 4.437E-4 8.962E-3
6.718E-2
4.482E-1
 3 451
46 AACTGAC,MIR-223:MSigDB AACTGAC,MIR-223:MSigDB MSigDB 4.442E-4 8.962E-3
6.718E-2
4.487E-1
 2 93
47 hsa-miR-103a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 4.495E-4 8.962E-3
6.718E-2
4.540E-1
 3 453
48 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 4.641E-4 8.962E-3
6.718E-2
4.687E-1
 3 458
49 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 4.670E-4 8.962E-3
6.718E-2
4.717E-1
 3 459
50 TGAATGT,MIR-181A:MSigDB TGAATGT,MIR-181A:MSigDB MSigDB 4.850E-4 8.962E-3
6.718E-2
4.898E-1
 3 465
Show 45 more annotations

17: Drug [Display Chart] 24 input genes in category / 6137 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000066161 MAPS Stitch 2.042E-19 1.253E-15 1.165E-14 1.253E-15 12 191
2 CID000004122 nocodazole Stitch 4.146E-18 1.272E-14 1.183E-13 2.544E-14 14 478
3 CID000173651 ML-236A Stitch 2.505E-7 5.125E-4 4.766E-3 1.538E-3 5 134
4 CID000003800 NSC613009 Stitch 1.005E-5 1.514E-2
1.408E-1
6.165E-2
 4 131
5 CID000446537 C-cluster Stitch 1.270E-5 1.514E-2
1.408E-1
7.792E-2
 4 139
6 ctd:C014215 tetrahydropalmatine CTD 1.759E-5 1.514E-2
1.408E-1
1.080E-1
 4 151
7 CID006420118 62 p Stitch 1.819E-5 1.514E-2
1.408E-1
1.116E-1
 3 49
8 CID000794323 S)-monastrol Stitch 2.441E-5 1.514E-2
1.408E-1
1.498E-1
 3 54
9 5990 DN Thalidomide [50-35-1]; Down 200; 15.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.507E-5 1.514E-2
1.408E-1
2.766E-1
 4 192
10 1419 DN Oxolinic acid [14698-29-4]; Down 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP Down 4.507E-5 1.514E-2
1.408E-1
2.766E-1
 4 192
11 7084 DN MS-275; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 4.599E-5 1.514E-2
1.408E-1
2.823E-1
 4 193
12 6704 DN Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 4.599E-5 1.514E-2
1.408E-1
2.823E-1
 4 193
13 3747 DN Flunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 4.693E-5 1.514E-2
1.408E-1
2.880E-1
 4 194
14 1336 UP SR-95639A [115767-94-7]; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.693E-5 1.514E-2
1.408E-1
2.880E-1
 4 194
15 3755 DN N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 4.788E-5 1.514E-2
1.408E-1
2.938E-1
 4 195
16 631 DN benserazide hydrochloride; Down 200; 10uM; SKMEL5; HG-U133A Broad Institute CMAP Down 4.884E-5 1.514E-2
1.408E-1
2.997E-1
 4 196
17 1692 DN Nifedipine [21829-25-4]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.884E-5 1.514E-2
1.408E-1
2.997E-1
 4 196
18 253 DN cox-2 inhibitor I; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 4.884E-5 1.514E-2
1.408E-1
2.997E-1
 4 196
19 5326 UP Ioversol [87771-40-2]; Up 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.081E-5 1.514E-2
1.408E-1
3.118E-1
 4 198
20 1590 DN Betamethasone [378-44-9]; Down 200; 10.2uM; HL60; HG-U133A Broad Institute CMAP Down 5.081E-5 1.514E-2
1.408E-1
3.118E-1
 4 198
21 5321 DN Nitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.182E-5 1.514E-2
1.408E-1
3.180E-1
 4 199
22 CID000008711 cyanoacrylate Stitch 5.786E-5 1.614E-2
1.501E-1
3.551E-1
 2 11
23 CID000351065 bu-b Stitch 7.085E-5 1.890E-2
1.758E-1
4.348E-1
 3 77
24 CID000005668 NSC91998 Stitch 8.241E-5 2.107E-2
1.960E-1
5.057E-1
 3 81
25 CID000030956 AC1L1KMJ Stitch 1.179E-4 2.894E-2
2.691E-1
7.235E-1
 5 476
26 ctd:C011269 2,5-hexanedione CTD 1.541E-4 3.202E-2
2.978E-1
9.460E-1
 3 100
27 CID000093168 D 617 Stitch 1.790E-4 3.202E-2
2.978E-1
1.000E0
 2 19
28 CID000074395 tetrazolium violet Stitch 1.790E-4 3.202E-2
2.978E-1
1.000E0
 2 19
29 CID000008149 IDPN Stitch 1.987E-4 3.202E-2
2.978E-1
1.000E0
 2 20
30 CID003037130 Acth(11-24) Stitch 2.413E-4 3.202E-2
2.978E-1
1.000E0
 2 22
31 ctd:C005219 methyl cellosolve CTD 2.616E-4 3.202E-2
2.978E-1
1.000E0
 4 303
32 CID000506900 RO033-4649 Stitch 2.641E-4 3.202E-2
2.978E-1
1.000E0
 2 23
33 CID000005133 NSC-131122 Stitch 2.879E-4 3.202E-2
2.978E-1
1.000E0
 2 24
34 CID000005082 AC1L1JKL Stitch 2.879E-4 3.202E-2
2.978E-1
1.000E0
 2 24
35 CID000627503 link Er Stitch 2.879E-4 3.202E-2
2.978E-1
1.000E0
 2 24
36 CID000122665 TBZ1 Stitch 3.128E-4 3.202E-2
2.978E-1
1.000E0
 2 25
37 CID000104972 norverapamil Stitch 3.933E-4 3.202E-2
2.978E-1
1.000E0
 2 28
38 CID005192834 AC1NQAAM Stitch 4.507E-4 3.202E-2
2.978E-1
1.000E0
 3 144
39 ctd:C063002 2,3-dimethoxy-1,4-naphthoquinone CTD 5.379E-4 3.202E-2
2.978E-1
1.000E0
 3 153
40 CID000449279 TRIBIZ Stitch 5.477E-4 3.202E-2
2.978E-1
1.000E0
 2 33
41 CID000107918 oligoadenylate Stitch 5.799E-4 3.202E-2
2.978E-1
1.000E0
 3 157
42 CID000110719 PiMM Stitch 6.164E-4 3.202E-2
2.978E-1
1.000E0
 2 35
43 ctd:D015741 Metribolone CTD 6.278E-4 3.202E-2
2.978E-1
1.000E0
 4 382
44 CID000002833 colchine Stitch 6.340E-4 3.202E-2
2.978E-1
1.000E0
 4 383
45 CID006442852 AC1O5Y0F Stitch 6.890E-4 3.202E-2
2.978E-1
1.000E0
 2 37
46 1000 UP SAHA; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 7.184E-4 3.202E-2
2.978E-1
1.000E0
 3 169
47 3791 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.308E-4 3.202E-2
2.978E-1
1.000E0
 3 170
48 3746 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.308E-4 3.202E-2
2.978E-1
1.000E0
 3 170
49 ctd:C500026 palbociclib CTD 7.433E-4 3.202E-2
2.978E-1
1.000E0
 3 171
50 2330 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.560E-4 3.202E-2
2.978E-1
1.000E0
 3 172
Show 45 more annotations

18: Disease [Display Chart] 23 input genes in category / 415 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3278481 MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 1 DisGeNET Curated 1.927E-6 7.997E-4 5.283E-3 7.997E-4 2 2
2 C0270764 Motor Neuron Disease, Lower DisGeNET BeFree 1.489E-4 3.089E-2
2.041E-1
6.179E-2
 2 13
3 C0334121 Inflammatory Myofibroblastic Tumor DisGeNET Curated 1.179E-3 3.465E-2
2.289E-1
4.892E-1
 2 36
4 C0233522 Inappropriate behavior DisGeNET Curated 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
5 C1336160 Stage IIA Esophageal Squamous Cell Carcinoma DisGeNET BeFree 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
6 C2678117 Schizophrenia-like symptoms (uncommon) DisGeNET Curated 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
7 C0239831 Hand muscle weakness DisGeNET Curated 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
8 OMIN:607641 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VIIB; HMN7B OMIM 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
9 C1848070 Lissencephaly and agenesis of corpus callosum DisGeNET BeFree 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
10 C1843315 Neuronopathy, Distal Hereditary Motor, Type Viib DisGeNET Curated 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
11 cv:C1848199 X-linked lissencephaly Clinical Variations 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
12 C0431379 Laminar heterotopia DisGeNET BeFree 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
13 cv:C1868594 Perry syndrome Clinical Variations 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
14 cv:C1843315 Distal hereditary motor neuronopathy type 7B Clinical Variations 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
15 C1319314 Transitional cell carcinoma of kidney DisGeNET BeFree 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
16 C4225225 SKIN CREASES, CONGENITAL SYMMETRIC CIRCUMFERENTIAL, 2 DisGeNET Curated 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
17 cv:C1855056 Microcephaly with chorioretinopathy, autosomal recessive Clinical Variations 1.419E-3 3.465E-2
2.289E-1
5.890E-1
 1 1
18 C0431380 Cortical Dysplasia DisGeNET Curated 2.541E-3 4.905E-2
3.241E-1
1.000E0
 2 53
19 C0473586 Michelin tire baby syndrome DisGeNET Curated 2.837E-3 4.905E-2
3.241E-1
1.000E0
 1 2
20 C0270763 Familial Motor Neuron Disease DisGeNET BeFree 2.837E-3 4.905E-2
3.241E-1
1.000E0
 1 2
21 C0239830 Hand muscle atrophy DisGeNET Curated 2.837E-3 4.905E-2
3.241E-1
1.000E0
 1 2
22 C4024809 Chorioretinal dysplasia DisGeNET Curated 2.837E-3 4.905E-2
3.241E-1
1.000E0
 1 2
23 C4024853 Increased number of skin folds DisGeNET Curated 2.837E-3 4.905E-2
3.241E-1
1.000E0
 1 2
24 C2931857 Double cortex DisGeNET BeFree 2.837E-3 4.905E-2
3.241E-1
1.000E0
 1 2
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