Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc45_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 53 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031625 ubiquitin protein ligase binding 1.038E-4 2.871E-3 1.308E-2 5.500E-3 3 273
2 GO:0044389 ubiquitin-like protein ligase binding 1.084E-4 2.871E-3 1.308E-2 5.743E-3 3 277
3 GO:0036139 peptidyl-histidine dioxygenase activity 3.751E-4 4.970E-3 2.265E-2 1.988E-2 1 1
4 GO:0036140 peptidyl-asparagine 3-dioxygenase activity 3.751E-4 4.970E-3 2.265E-2 1.988E-2 1 1
5 GO:0019826 oxygen sensor activity 1.125E-3 1.192E-2
5.434E-2
5.962E-2
 1 3
6 GO:0071532 ankyrin repeat binding 1.500E-3 1.325E-2
6.037E-2
7.949E-2
 1 4
7 GO:0017160 Ral GTPase binding 4.867E-3 3.685E-2
1.679E-1
2.580E-1
 1 13
8 GO:0005112 Notch binding 7.479E-3 4.955E-2
2.258E-1
3.964E-1
 1 20
Show 3 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 562 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 2.665E-13 1.498E-10 1.035E-9 1.498E-10 5 33
2 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 8.537E-12 2.399E-9 1.658E-8 4.798E-9 5 64
3 GO:0043620 regulation of DNA-templated transcription in response to stress 1.354E-11 2.537E-9 1.753E-8 7.612E-9 5 70
4 GO:0071456 cellular response to hypoxia 5.162E-10 7.252E-8 5.011E-7 2.901E-7 5 143
5 GO:0036294 cellular response to decreased oxygen levels 6.573E-10 7.388E-8 5.105E-7 3.694E-7 5 150
6 GO:0071453 cellular response to oxygen levels 8.546E-10 8.005E-8 5.531E-7 4.803E-7 5 158
7 GO:0001666 response to hypoxia 2.612E-8 2.097E-6 1.449E-5 1.468E-5 5 312
8 GO:0036293 response to decreased oxygen levels 3.011E-8 2.115E-6 1.462E-5 1.692E-5 5 321
9 GO:0070482 response to oxygen levels 3.898E-8 2.434E-6 1.682E-5 2.191E-5 5 338
10 GO:1903928 cellular response to cyanide 3.759E-4 1.509E-2
1.043E-1
2.112E-1
 1 1
11 GO:0042265 peptidyl-asparagine hydroxylation 3.759E-4 1.509E-2
1.043E-1
2.112E-1
 1 1
12 GO:0036138 peptidyl-histidine hydroxylation 3.759E-4 1.509E-2
1.043E-1
2.112E-1
 1 1
13 GO:0021502 neural fold elevation formation 3.759E-4 1.509E-2
1.043E-1
2.112E-1
 1 1
14 GO:1903927 response to cyanide 3.759E-4 1.509E-2
1.043E-1
2.112E-1
 1 1
15 GO:0006368 transcription elongation from RNA polymerase II promoter 5.544E-4 2.077E-2
1.435E-1
3.116E-1
 2 97
16 GO:0072347 response to anesthetic 7.516E-4 2.112E-2
1.459E-1
4.224E-1
 1 2
17 GO:0071250 cellular response to nitrite 7.516E-4 2.112E-2
1.459E-1
4.224E-1
 1 2
18 GO:0080033 response to nitrite 7.516E-4 2.112E-2
1.459E-1
4.224E-1
 1 2
19 GO:0071245 cellular response to carbon monoxide 7.516E-4 2.112E-2
1.459E-1
4.224E-1
 1 2
20 GO:0042264 peptidyl-aspartic acid hydroxylation 7.516E-4 2.112E-2
1.459E-1
4.224E-1
 1 2
21 GO:0006354 DNA-templated transcription, elongation 9.181E-4 2.457E-2
1.698E-1
5.160E-1
 2 125
22 GO:0070101 positive regulation of chemokine-mediated signaling pathway 1.127E-3 2.754E-2
1.903E-1
6.335E-1
 1 3
23 GO:0018197 peptidyl-aspartic acid modification 1.127E-3 2.754E-2
1.903E-1
6.335E-1
 1 3
24 GO:1904018 positive regulation of vasculature development 1.301E-3 3.046E-2
2.104E-1
7.309E-1
 2 149
25 GO:0060574 intestinal epithelial cell maturation 1.503E-3 3.128E-2
2.161E-1
8.446E-1
 1 4
26 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development 1.503E-3 3.128E-2
2.161E-1
8.446E-1
 1 4
27 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia 1.503E-3 3.128E-2
2.161E-1
8.446E-1
 1 4
28 GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia 1.878E-3 3.199E-2
2.210E-1
1.000E0
 1 5
29 GO:0051541 elastin metabolic process 1.878E-3 3.199E-2
2.210E-1
1.000E0
 1 5
30 GO:0001922 B-1 B cell homeostasis 1.878E-3 3.199E-2
2.210E-1
1.000E0
 1 5
31 GO:0071279 cellular response to cobalt ion 1.878E-3 3.199E-2
2.210E-1
1.000E0
 1 5
32 GO:0034465 response to carbon monoxide 1.878E-3 3.199E-2
2.210E-1
1.000E0
 1 5
33 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.878E-3 3.199E-2
2.210E-1
1.000E0
 1 5
34 GO:1903599 positive regulation of autophagy of mitochondrion 2.253E-3 3.333E-2
2.303E-1
1.000E0
 1 6
35 GO:0019896 axonal transport of mitochondrion 2.253E-3 3.333E-2
2.303E-1
1.000E0
 1 6
36 GO:0097709 connective tissue replacement 2.253E-3 3.333E-2
2.303E-1
1.000E0
 1 6
37 GO:0032364 oxygen homeostasis 2.253E-3 3.333E-2
2.303E-1
1.000E0
 1 6
38 GO:0002248 connective tissue replacement involved in inflammatory response wound healing 2.253E-3 3.333E-2
2.303E-1
1.000E0
 1 6
39 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway 2.629E-3 3.592E-2
2.482E-1
1.000E0
 1 7
40 GO:1903715 regulation of aerobic respiration 2.629E-3 3.592E-2
2.482E-1
1.000E0
 1 7
41 GO:0001842 neural fold formation 2.629E-3 3.592E-2
2.482E-1
1.000E0
 1 7
42 GO:0002069 columnar/cuboidal epithelial cell maturation 3.004E-3 3.592E-2
2.482E-1
1.000E0
 1 8
43 GO:0032909 regulation of transforming growth factor beta2 production 3.004E-3 3.592E-2
2.482E-1
1.000E0
 1 8
44 GO:0032906 transforming growth factor beta2 production 3.004E-3 3.592E-2
2.482E-1
1.000E0
 1 8
45 GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress 3.004E-3 3.592E-2
2.482E-1
1.000E0
 1 8
46 GO:0070099 regulation of chemokine-mediated signaling pathway 3.004E-3 3.592E-2
2.482E-1
1.000E0
 1 8
47 GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 3.004E-3 3.592E-2
2.482E-1
1.000E0
 1 8
48 GO:0090594 inflammatory response to wounding 3.379E-3 3.723E-2
2.572E-1
1.000E0
 1 9
49 GO:0033483 gas homeostasis 3.379E-3 3.723E-2
2.572E-1
1.000E0
 1 9
50 GO:0002246 wound healing involved in inflammatory response 3.379E-3 3.723E-2
2.572E-1
1.000E0
 1 9
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 32 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030891 VCB complex 4.454E-13 1.425E-11 5.784E-11 1.425E-11 4 8
2 GO:0000153 cytoplasmic ubiquitin ligase complex 8.677E-12 1.388E-10 5.634E-10 2.777E-10 4 15
3 GO:0000151 ubiquitin ligase complex 1.413E-6 1.507E-5 6.118E-5 4.522E-5 4 274
4 GO:0070449 elongin complex 2.426E-6 1.940E-5 7.875E-5 7.762E-5 2 7
5 GO:0031462 Cul2-RING ubiquitin ligase complex 6.348E-6 4.063E-5 1.649E-4 2.031E-4 2 11
6 GO:0008023 transcription elongation factor complex 1.404E-4 7.490E-4 3.040E-3 4.494E-3 2 50
7 GO:0031461 cullin-RING ubiquitin ligase complex 1.326E-3 6.063E-3 2.460E-2 4.244E-2 2 154
8 GO:0031466 Cul5-RING ubiquitin ligase complex 2.202E-3 8.807E-3 3.574E-2
7.045E-2
 1 6
9 GO:0030914 STAGA complex 5.131E-3 1.824E-2
7.404E-2
1.642E-1
 1 14
10 GO:0070822 Sin3-type complex 6.227E-3 1.993E-2
8.088E-2
1.993E-1
 1 17
11 GO:0070461 SAGA-type complex 1.242E-2 3.506E-2
1.423E-1
3.975E-1
 1 34
12 GO:1904115 axon cytoplasm 1.315E-2 3.506E-2
1.423E-1
4.207E-1
 1 36
Show 7 more annotations

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 421 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 7 input genes in category / 72 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001321 HIF-1 alpha InterPro 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
2 IPR024137 His deAcase cplx SAP130 InterPro 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
3 1.10.287.1010 - Gene3D 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
4 PF16014 SAP130 C Pfam 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
5 IPR031963 SAP130 C InterPro 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
6 IPR027452 FIH-1 domII InterPro 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
7 IPR027445 FIH-1 InterPro 3.736E-4 3.843E-3 1.868E-2 2.690E-2 1 1
8 PF03931 Skp1 POZ Pfam 7.471E-4 4.138E-3 2.011E-2
5.379E-2
 1 2
9 PF08778 HIF-1a CTAD Pfam 7.471E-4 4.138E-3 2.011E-2
5.379E-2
 1 2
10 IPR001232 SKP1-like InterPro 7.471E-4 4.138E-3 2.011E-2
5.379E-2
 1 2
11 IPR014887 HIF-1 TAD C InterPro 7.471E-4 4.138E-3 2.011E-2
5.379E-2
 1 2
12 SM00512 Skp1 SMART 7.471E-4 4.138E-3 2.011E-2
5.379E-2
 1 2
13 IPR016073 Skp1 comp POZ InterPro 7.471E-4 4.138E-3 2.011E-2
5.379E-2
 1 2
14 PF11413 HIF-1 Pfam 1.121E-3 5.379E-3 2.614E-2
8.068E-2
 1 3
15 IPR021537 HIF alpha subunit InterPro 1.121E-3 5.379E-3 2.614E-2
8.068E-2
 1 3
16 SM00695 DUSP SMART 2.240E-3 8.180E-3 3.976E-2
1.613E-1
 1 6
17 PF06337 DUSP Pfam 2.240E-3 8.180E-3 3.976E-2
1.613E-1
 1 6
18 PS51283 DUSP PROSITE 2.613E-3 8.180E-3 3.976E-2
1.881E-1
 1 7
19 IPR016157 Cullin CS InterPro 2.613E-3 8.180E-3 3.976E-2
1.881E-1
 1 7
20 IPR006615 Pept C19 DUSP InterPro 2.613E-3 8.180E-3 3.976E-2
1.881E-1
 1 7
21 SM00182 CULLIN SMART 2.613E-3 8.180E-3 3.976E-2
1.881E-1
 1 7
22 3.30.2230.10 - Gene3D 2.613E-3 8.180E-3 3.976E-2
1.881E-1
 1 7
23 PF08007 Cupin 4 Pfam 2.613E-3 8.180E-3 3.976E-2
1.881E-1
 1 7
24 PF10557 Cullin Nedd8 Pfam 2.986E-3 8.268E-3 4.019E-2
2.150E-1
 1 8
25 IPR019559 Cullin neddylation domain InterPro 2.986E-3 8.268E-3 4.019E-2
2.150E-1
 1 8
26 SM00884 Cullin Nedd8 SMART 2.986E-3 8.268E-3 4.019E-2
2.150E-1
 1 8
27 IPR016158 Cullin homology InterPro 3.358E-3 8.665E-3 4.212E-2
2.418E-1
 1 9
28 PS50069 CULLIN 2 PROSITE 3.731E-3 8.665E-3 4.212E-2
2.686E-1
 1 10
29 IPR001373 Cullin N InterPro 3.731E-3 8.665E-3 4.212E-2
2.686E-1
 1 10
30 PS01256 CULLIN 1 PROSITE 3.731E-3 8.665E-3 4.212E-2
2.686E-1
 1 10
31 PF00888 Cullin Pfam 3.731E-3 8.665E-3 4.212E-2
2.686E-1
 1 10
32 SM00290 ZnF UBP SMART 4.103E-3 9.233E-3 4.488E-2
2.954E-1
 1 11
33 IPR016159 Cullin repeat-like dom InterPro 4.476E-3 9.765E-3 4.747E-2
3.223E-1
 1 12
34 IPR001607 Znf UBP InterPro 5.220E-3 1.044E-2
5.075E-2
3.758E-1
 1 14
35 PF02148 zf-UBP Pfam 5.220E-3 1.044E-2
5.075E-2
3.758E-1
 1 14
36 PS50271 ZF UBP PROSITE 5.220E-3 1.044E-2
5.075E-2
3.758E-1
 1 14
37 IPR013655 PAS fold 3 InterPro 8.563E-3 1.583E-2
7.696E-2
6.166E-1
 1 23
38 PF08447 PAS 3 Pfam 8.563E-3 1.583E-2
7.696E-2
6.166E-1
 1 23
39 IPR000700 PAS-assoc C InterPro 8.934E-3 1.583E-2
7.696E-2
6.433E-1
 1 24
40 PF00989 PAS Pfam 9.305E-3 1.583E-2
7.696E-2
6.700E-1
 1 25
41 IPR013767 PAS fold InterPro 9.305E-3 1.583E-2
7.696E-2
6.700E-1
 1 25
42 SM00086 PAC SMART 9.676E-3 1.583E-2
7.696E-2
6.966E-1
 1 26
43 PS50113 PAC PROSITE 9.676E-3 1.583E-2
7.696E-2
6.966E-1
 1 26
44 IPR001610 PAC InterPro 9.676E-3 1.583E-2
7.696E-2
6.966E-1
 1 26
45 IPR003347 JmjC dom InterPro 1.190E-2 1.820E-2
8.845E-2
8.566E-1
 1 32
46 SM00091 PAS SMART 1.190E-2 1.820E-2
8.845E-2
8.566E-1
 1 32
47 PS51184 JMJC PROSITE 1.190E-2 1.820E-2
8.845E-2
8.566E-1
 1 32
48 SM00558 JmjC SMART 1.227E-2 1.820E-2
8.845E-2
8.832E-1
 1 33
49 PS50112 PAS PROSITE 1.264E-2 1.820E-2
8.845E-2
9.098E-1
 1 34
50 IPR000014 PAS InterPro 1.264E-2 1.820E-2
8.845E-2
9.098E-1
 1 34
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 75 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138056 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha BioSystems: Pathway Interaction Database 2.529E-14 1.896E-12 9.295E-12 1.896E-12 5 15
2 1270415 Cellular response to hypoxia BioSystems: REACTOME 1.881E-10 4.704E-9 2.305E-8 1.411E-8 5 79
3 1270416 Regulation of Hypoxia-inducible Factor (HIF) by oxygen BioSystems: REACTOME 1.881E-10 4.704E-9 2.305E-8 1.411E-8 5 79
4 83107 Renal cell carcinoma BioSystems: KEGG 2.340E-8 4.388E-7 2.151E-6 1.755E-6 4 65
5 1270418 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 2.986E-8 4.479E-7 2.195E-6 2.240E-6 4 69
6 695200 HIF-1 signaling pathway BioSystems: KEGG 1.402E-7 1.752E-6 8.587E-6 1.051E-5 4 101
7 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 6.465E-7 6.927E-6 3.395E-5 4.849E-5 3 34
8 1270417 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 8.127E-7 7.619E-6 3.735E-5 6.096E-5 2 3
9 1270414 Cellular responses to stress BioSystems: REACTOME 1.247E-6 1.039E-5 5.094E-5 9.353E-5 5 454
10 PW:0000360 the chronic hypoxic response - the hypoxia inducible factor - alpha Pathway Ontology 4.060E-6 3.045E-5 1.493E-4 3.045E-4 2 6
11 83105 Pathways in cancer BioSystems: KEGG 3.238E-5 2.208E-4 1.082E-3 2.428E-3 4 395
12 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 4.418E-5 2.761E-4 1.353E-3 3.313E-3 3 137
13 1269082 Tat-mediated HIV elongation arrest and recovery BioSystems: REACTOME 2.092E-4 1.082E-3 5.303E-3 1.569E-2 2 40
14 1269083 Pausing and recovery of Tat-mediated HIV elongation BioSystems: REACTOME 2.092E-4 1.082E-3 5.303E-3 1.569E-2 2 40
15 1269079 HIV elongation arrest and recovery BioSystems: REACTOME 2.308E-4 1.082E-3 5.303E-3 1.731E-2 2 42
16 1269081 Pausing and recovery of HIV elongation BioSystems: REACTOME 2.308E-4 1.082E-3 5.303E-3 1.731E-2 2 42
17 1269076 Tat-mediated elongation of the HIV-1 transcript BioSystems: REACTOME 3.545E-4 1.400E-3 6.860E-3 2.659E-2 2 52
18 1269077 Formation of HIV-1 elongation complex containing HIV-1 Tat BioSystems: REACTOME 3.545E-4 1.400E-3 6.860E-3 2.659E-2 2 52
19 1269074 HIV Transcription Elongation BioSystems: REACTOME 3.545E-4 1.400E-3 6.860E-3 2.659E-2 2 52
20 1269080 Formation of HIV elongation complex in the absence of HIV Tat BioSystems: REACTOME 3.824E-4 1.434E-3 7.029E-3 2.868E-2 2 54
21 1269098 Vif-mediated degradation of APOBEC3G BioSystems: REACTOME 4.262E-4 1.522E-3 7.460E-3 3.196E-2 2 57
22 1269193 Antigen processing: Ubiquitination & Proteasome degradation BioSystems: REACTOME 5.158E-4 1.758E-3 8.619E-3 3.869E-2 3 314
23 1269682 RNA Polymerase II Transcription Elongation BioSystems: REACTOME 5.888E-4 1.840E-3 9.018E-3 4.416E-2 2 67
24 1269684 Formation of RNA Pol II elongation complex BioSystems: REACTOME 5.888E-4 1.840E-3 9.018E-3 4.416E-2 2 67
25 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 6.798E-4 2.039E-3 9.995E-3
5.098E-2
 2 72
26 1269070 Transcription of the HIV genome BioSystems: REACTOME 8.178E-4 2.359E-3 1.156E-2
6.134E-2
 2 79
27 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 8.737E-4 2.427E-3 1.190E-2
6.553E-2
 3 376
28 1269676 RNA Polymerase II Pre-transcription Events BioSystems: REACTOME 1.060E-3 2.839E-3 1.392E-2
7.950E-2
 2 90
29 1269091 Host Interactions of HIV factors BioSystems: REACTOME 2.400E-3 6.206E-3 3.042E-2
1.800E-1
 2 136
30 1269069 Late Phase of HIV Life Cycle BioSystems: REACTOME 2.577E-3 6.442E-3 3.157E-2
1.933E-1
 2 141
31 1383026 PTK6 Expression BioSystems: REACTOME 2.809E-3 6.795E-3 3.330E-2
2.106E-1
 1 5
32 1269058 HIV Life Cycle BioSystems: REACTOME 3.065E-3 7.183E-3 3.521E-2
2.299E-1
 2 154
33 1383032 PTK6 promotes HIF1A stabilization BioSystems: REACTOME 3.369E-3 7.468E-3 3.660E-2
2.527E-1
 1 6
34 1269675 RNA Polymerase II Transcription BioSystems: REACTOME 3.385E-3 7.468E-3 3.660E-2
2.539E-1
 2 162
35 PW:0000435 neddylation Pathway Ontology 6.170E-3 1.251E-2
6.130E-2
4.627E-1
 1 11
36 M6917 Erythropoietin mediated neuroprotection through NF-kB MSigDB C2 BIOCARTA (v6.0) 6.170E-3 1.251E-2
6.130E-2
4.627E-1
 1 11
37 PW:0000415 proteasome degradation involving cullin-dependent ubiquitin ligases Pathway Ontology 6.170E-3 1.251E-2
6.130E-2
4.627E-1
 1 11
38 1427862 Ub-specific processing proteases BioSystems: REACTOME 6.432E-3 1.269E-2
6.222E-2
4.824E-1
 2 225
39 1270419 Regulation of gene expression by Hypoxia-inducible Factor BioSystems: REACTOME 6.729E-3 1.294E-2
6.343E-2
5.047E-1
 1 12
40 1269057 HIV Infection BioSystems: REACTOME 7.290E-3 1.367E-2
6.700E-2
5.468E-1
 2 240
41 M13324 Hypoxia-Inducible Factor in the Cardiovascular System MSigDB C2 BIOCARTA (v6.0) 8.405E-3 1.538E-2
7.536E-2
6.304E-1
 1 15
42 1427860 Deubiquitination BioSystems: REACTOME 1.143E-2 2.042E-2
1.001E-1
8.576E-1
 2 303
43 M5202 Hypoxia and p53 in the Cardiovascular system MSigDB C2 BIOCARTA (v6.0) 1.286E-2 2.244E-2
1.100E-1
9.648E-1
 1 23
44 PW:0000243 vascular endothelial growth factor signaling Pathway Ontology 1.342E-2 2.287E-2
1.121E-1
1.000E0
 1 24
45 P00030 Hypoxia response via HIF activation PantherDB 1.453E-2 2.422E-2
1.187E-1
1.000E0
 1 26
46 M12975 VEGF, Hypoxia, and Angiogenesis MSigDB C2 BIOCARTA (v6.0) 1.620E-2 2.584E-2
1.267E-1
1.000E0
 1 29
47 137924 VEGFR1 specific signals BioSystems: Pathway Interaction Database 1.620E-2 2.584E-2
1.267E-1
1.000E0
 1 29
48 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 1.710E-2 2.672E-2
1.310E-1
1.000E0
 2 374
49 1269056 Infectious disease BioSystems: REACTOME 1.879E-2 2.876E-2
1.409E-1
1.000E0
 2 393
50 169347 Notch-mediated HES/HEY network BioSystems: Pathway Interaction Database 2.668E-2 3.849E-2
1.886E-1
1.000E0
 1 48
Show 45 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 4258 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19940151 Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. Pubmed 1.433E-17 6.100E-14 5.450E-13 6.100E-14 5 11
2 12004076 Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Pubmed 5.922E-15 6.537E-12 5.840E-11 2.521E-11 4 6
3 15060148 pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Pubmed 5.922E-15 6.537E-12 5.840E-11 2.521E-11 4 6
4 10973499 Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Pubmed 1.382E-14 6.537E-12 5.840E-11 5.883E-11 4 7
5 26743088 Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. Pubmed 1.382E-14 6.537E-12 5.840E-11 5.883E-11 4 7
6 17244529 RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Pubmed 1.382E-14 6.537E-12 5.840E-11 5.883E-11 4 7
7 10823831 Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. Pubmed 1.382E-14 6.537E-12 5.840E-11 5.883E-11 4 7
8 19030229 VHL type 2B mutations retain VBC complex form and function. Pubmed 1.382E-14 6.537E-12 5.840E-11 5.883E-11 4 7
9 18323857 NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. Pubmed 1.382E-14 6.537E-12 5.840E-11 5.883E-11 4 7
10 28775317 Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Pubmed 4.973E-14 2.118E-11 1.892E-10 2.118E-10 4 9
11 11006129 Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. Pubmed 3.770E-12 1.459E-9 1.304E-8 1.605E-8 3 3
12 25661653 Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex. Pubmed 1.508E-11 3.776E-9 3.374E-8 6.420E-8 3 4
13 11739384 Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. Pubmed 1.508E-11 3.776E-9 3.374E-8 6.420E-8 3 4
14 12050673 Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Pubmed 1.508E-11 3.776E-9 3.374E-8 6.420E-8 3 4
15 10535940 Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Pubmed 1.508E-11 3.776E-9 3.374E-8 6.420E-8 3 4
16 9122164 The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Pubmed 1.508E-11 3.776E-9 3.374E-8 6.420E-8 3 4
17 7660130 Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Pubmed 1.508E-11 3.776E-9 3.374E-8 6.420E-8 3 4
18 19327355 Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
19 26751167 CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
20 10449727 Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
21 24402281 Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
22 10587522 Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
23 17304241 The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
24 9751722 pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
25 20049704 Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex. Pubmed 3.769E-11 6.419E-9 5.735E-8 1.605E-7 3 5
26 19706539 Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. Pubmed 7.538E-11 1.146E-8 1.024E-7 3.209E-7 3 6
27 26846855 Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. Pubmed 7.538E-11 1.146E-8 1.024E-7 3.209E-7 3 6
28 25500545 RSUME inhibits VHL and regulates its tumor suppressor function. Pubmed 7.538E-11 1.146E-8 1.024E-7 3.209E-7 3 6
29 21822215 The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
30 22537386 UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
31 23401859 DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
32 17786314 MM-1 facilitates degradation of c-Myc by recruiting proteasome and a novel ubiquitin E3 ligase. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
33 12604794 von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
34 15611064 Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
35 15966899 Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. Pubmed 1.319E-10 1.605E-8 1.434E-7 5.616E-7 3 7
36 23460923 PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs. Pubmed 2.110E-10 2.246E-8 2.007E-7 8.985E-7 3 8
37 24469044 The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Pubmed 2.110E-10 2.246E-8 2.007E-7 8.985E-7 3 8
38 17069461 EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. Pubmed 2.110E-10 2.246E-8 2.007E-7 8.985E-7 3 8
39 17636018 ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Pubmed 2.110E-10 2.246E-8 2.007E-7 8.985E-7 3 8
40 12149480 Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Pubmed 2.110E-10 2.246E-8 2.007E-7 8.985E-7 3 8
41 18775313 UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Pubmed 2.195E-10 2.279E-8 2.036E-7 9.344E-7 4 62
42 17339318 Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor. Pubmed 6.216E-10 6.302E-8 5.630E-7 2.647E-6 3 11
43 21119685 Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Pubmed 8.287E-10 8.020E-8 7.165E-7 3.529E-6 3 12
44 11384984 Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. Pubmed 8.287E-10 8.020E-8 7.165E-7 3.529E-6 3 12
45 22286099 The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Pubmed 1.077E-9 9.972E-8 8.909E-7 4.587E-6 3 13
46 17986458 A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Pubmed 1.077E-9 9.972E-8 8.909E-7 4.587E-6 3 13
47 24076655 TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. Pubmed 1.371E-9 1.216E-7 1.087E-6 5.838E-6 3 14
48 18173839 Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. Pubmed 1.371E-9 1.216E-7 1.087E-6 5.838E-6 3 14
49 15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Pubmed 2.561E-9 2.225E-7 1.988E-6 1.090E-5 3 17
50 18187417 Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. Pubmed 3.072E-9 2.616E-7 2.338E-6 1.308E-5 3 18
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 1141 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ELOB ELOB interactions 6.971E-16 7.953E-13 6.058E-12 7.953E-13 7 124
2 int:VHL VHL interactions 1.385E-12 7.899E-10 6.017E-9 1.580E-9 7 361
3 int:ELOC ELOC interactions 2.625E-12 9.984E-10 7.605E-9 2.995E-9 6 153
4 int:FEM1B FEM1B interactions 2.489E-9 7.099E-7 5.407E-6 2.840E-6 4 53
5 int:LRRC14 LRRC14 interactions 6.238E-9 1.424E-6 1.084E-5 7.118E-6 3 11
6 int:DIO2 DIO2 interactions 1.719E-8 3.269E-6 2.490E-5 1.961E-5 3 15
7 int:ASB13 ASB13 interactions 3.658E-8 5.963E-6 4.542E-5 4.174E-5 3 19
8 int:PCMTD2 PCMTD2 interactions 5.020E-8 7.127E-6 5.429E-5 5.727E-5 3 21
9 int:ASB16 ASB16 interactions 5.811E-8 7.127E-6 5.429E-5 6.631E-5 3 22
10 int:UBXN7 UBXN7 interactions 6.246E-8 7.127E-6 5.429E-5 7.127E-5 4 117
11 int:ASB5 ASB5 interactions 7.635E-8 7.614E-6 5.800E-5 8.712E-5 3 24
12 int:HIF1A HIF1A interactions 8.312E-8 7.614E-6 5.800E-5 9.484E-5 5 374
13 int:ASB8 ASB8 interactions 8.675E-8 7.614E-6 5.800E-5 9.898E-5 3 25
14 int:ASB4 ASB4 interactions 1.103E-7 8.289E-6 6.314E-5 1.258E-4 3 27
15 int:ASB10 ASB10 interactions 1.103E-7 8.289E-6 6.314E-5 1.258E-4 3 27
16 int:LRR1 LRR1 interactions 1.235E-7 8.289E-6 6.314E-5 1.409E-4 3 28
17 int:ZER1 ZER1 interactions 1.235E-7 8.289E-6 6.314E-5 1.409E-4 3 28
18 int:CUL2 CUL2 interactions 2.461E-7 1.533E-5 1.168E-4 2.808E-4 5 465
19 int:CISH CISH interactions 2.688E-7 1.533E-5 1.168E-4 3.067E-4 3 36
20 int:ASB9 ASB9 interactions 2.688E-7 1.533E-5 1.168E-4 3.067E-4 3 36
21 int:ARNT ARNT interactions 3.084E-7 1.647E-5 1.254E-4 3.519E-4 4 174
22 int:ASB2 ASB2 interactions 3.175E-7 1.647E-5 1.254E-4 3.622E-4 3 38
23 int:RBX1 RBX1 interactions 3.455E-7 1.714E-5 1.306E-4 3.942E-4 4 179
24 int:ASB7 ASB7 interactions 5.334E-7 2.536E-5 1.932E-4 6.086E-4 3 45
25 int:EPOR EPOR interactions 6.093E-7 2.648E-5 2.017E-4 6.952E-4 3 47
26 int:USP33 USP33 interactions 6.498E-7 2.648E-5 2.017E-4 7.414E-4 3 48
27 int:LAGE3 LAGE3 interactions 6.498E-7 2.648E-5 2.017E-4 7.414E-4 3 48
28 int:ZYG11B ZYG11B interactions 6.498E-7 2.648E-5 2.017E-4 7.414E-4 3 48
29 int:PRAME PRAME interactions 7.361E-7 2.896E-5 2.206E-4 8.399E-4 3 50
30 int:KLHDC2 KLHDC2 interactions 7.820E-7 2.958E-5 2.254E-4 8.923E-4 3 51
31 int:ELOA3 ELOA3 interactions 8.038E-7 2.958E-5 2.254E-4 9.172E-4 2 4
32 int:ASB6 ASB6 interactions 8.297E-7 2.958E-5 2.254E-4 9.467E-4 3 52
33 int:SAP130 SAP130 interactions 9.309E-7 3.219E-5 2.452E-4 1.062E-3 3 54
34 int:KLHDC3 KLHDC3 interactions 1.040E-6 3.490E-5 2.659E-4 1.187E-3 3 56
35 int:DCUN1D1 DCUN1D1 interactions 1.098E-6 3.581E-5 2.728E-4 1.253E-3 4 239
36 int:FAF2 FAF2 interactions 1.357E-6 4.301E-5 3.276E-4 1.548E-3 4 252
37 int:ASB3 ASB3 interactions 1.488E-6 4.468E-5 3.404E-4 1.698E-3 3 63
38 int:RNF7 RNF7 interactions 1.488E-6 4.468E-5 3.404E-4 1.698E-3 3 63
39 int:MED8 MED8 interactions 1.561E-6 4.567E-5 3.479E-4 1.781E-3 3 64
40 int:RACK1 RACK1 interactions 1.609E-6 4.590E-5 3.496E-4 1.836E-3 4 263
41 int:NEDD8 NEDD8 interactions 1.813E-6 5.046E-5 3.844E-4 2.069E-3 4 271
42 int:HIF1AN HIF1AN interactions 2.095E-6 5.676E-5 4.323E-4 2.390E-3 4 281
43 int:DNAJB6 DNAJB6 interactions 2.139E-6 5.676E-5 4.323E-4 2.441E-3 3 71
44 int:COMMD1 COMMD1 interactions 2.525E-6 6.549E-5 4.988E-4 2.881E-3 3 75
45 int:OSGEP OSGEP interactions 2.629E-6 6.665E-5 5.077E-4 2.999E-3 3 76
46 int:ANKRD39 ANKRD39 interactions 2.812E-6 6.975E-5 5.313E-4 3.208E-3 2 7
47 int:SOCS1 SOCS1 interactions 3.308E-6 8.031E-5 6.117E-4 3.774E-3 3 82
48 int:SQSTM1 SQSTM1 interactions 3.427E-6 8.146E-5 6.205E-4 3.910E-3 4 318
49 int:SAT2 SAT2 interactions 3.748E-6 8.728E-5 6.649E-4 4.277E-3 2 8
50 int:RBM3 RBM3 interactions 6.022E-6 1.347E-4 1.026E-3 6.871E-3 3 100
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10p11.21 10p11.21 3.831E-3 8.222E-3 2.132E-2 2.682E-2 1 19
2 14q23.2 14q23.2 4.032E-3 8.222E-3 2.132E-2 2.823E-2 1 20
3 2q14.3 2q14.3 5.642E-3 8.222E-3 2.132E-2 3.949E-2 1 28
4 8q21.11 8q21.11 5.843E-3 8.222E-3 2.132E-2 4.090E-2 1 29
5 16p12.3 16p12.3 6.847E-3 8.222E-3 2.132E-2 4.793E-2 1 34
6 10q24 10q24 7.048E-3 8.222E-3 2.132E-2 4.933E-2 1 35
7 1p31.1 1p31.1 1.425E-2 1.425E-2 3.695E-2
9.977E-2
 1 71
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 52 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1032 Cullins genenames.org 1.319E-3 3.956E-3 7.252E-3 3.956E-3 1 8
2 366 Ubiquitin specific peptidases genenames.org 9.206E-3 1.381E-2 2.532E-2 2.762E-2 1 56
3 420 Basic helix-loop-helix proteins genenames.org 1.803E-2 1.803E-2 3.305E-2
5.409E-2
 1 110

13: Coexpression [Display Chart] 7 input genes in category / 662 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19074895-Table3 Human Liver Sakai08 86genes GeneSigDB 1.486E-6 5.104E-4 3.610E-3 9.840E-4 3 82
2 M9224 Selected genes up-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.542E-6 5.104E-4 3.610E-3 1.021E-3 3 83
3 17234769-TableS5a Human StemCell West07 23genes GeneSigDB 1.198E-5 2.643E-3 1.869E-2 7.929E-3 2 18
4 M14030 Up-regulated genes in pediatric adrenocortical carcinoma (ACC) compared to the adenoma (ACA) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.643E-5 2.719E-3 1.924E-2 1.088E-2 2 21
5 15467184-Table1a Human Stomach Lee04 37genes GeneSigDB 5.199E-5 6.884E-3 4.869E-2 3.442E-2 2 37
6 M870 Genes down-regulated in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of congenic B.D. chr3 (BD, large HSC size) vs parental B6 strain (tiny HSC size). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.720E-5 8.517E-3
6.025E-2
5.110E-2
 2 45
7 16269079-TableS4 Human StemCell Cui05 113genes GeneSigDB 4.301E-4 2.870E-2
2.030E-1
2.848E-1
 2 106
8 12714683-Table5 Human Breast Ma02 200genes grade GeneSigDB 1.087E-3 2.870E-2
2.030E-1
7.198E-1
 2 169
9 M2943 Genes up-regulated in gamma delta intraepithelial lymphocytes from colon: control versus colitis induced by dextran sulfate sodium (DSS). MSigDB C7: Immunologic Signatures (v6.0) 1.205E-3 2.870E-2
2.030E-1
7.977E-1
 2 178
10 M6878 Genes down-regulated during B lymphocyte differentiation: large pre-B II versus VPREB1+ [GeneID=7441] pre-B Il. MSigDB C7: Immunologic Signatures (v6.0) 1.218E-3 2.870E-2
2.030E-1
8.066E-1
 2 179
11 18691415-Table5e Human Colon Solmi08 204genes GeneSigDB 1.259E-3 2.870E-2
2.030E-1
8.336E-1
 2 182
12 M7929 Genes down-regulated in wildtype bone marrow-derived macrophages: control versus treated with IL4 [GeneID=3565] and rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 1.443E-3 2.870E-2
2.030E-1
9.555E-1
 2 195
13 M4926 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee before vaccination versus that after the vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.458E-3 2.870E-2
2.030E-1
9.652E-1
 2 196
14 M10017 Genes down-regulated in tumor associated macrophages conditioned by: glioblastoma versus colorectal adenocarcinoma. MSigDB C7: Immunologic Signatures (v6.0) 1.473E-3 2.870E-2
2.030E-1
9.750E-1
 2 197
15 M4930 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 2.870E-2
2.030E-1
9.848E-1
 2 198
16 M7835 Genes up-regulated in dendritic cells: plasmacytoid versus cultured common progenitors treated by TGFB1 [GeneID=7040] for 4h. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.870E-2
2.030E-1
9.946E-1
 2 199
17 M9942 Genes up-regulated in B lymphocytes treated by anti IgM for 6h: wildtype versus MAP3K7 [GeneID=6885] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
18 M7211 Genes up-regulated inmouse embryonic fibroblasts (MEF): control versus LPS and heat shock. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
19 M7365 Genes up-regulated in the activated CD4 [GeneID=920] T cells (48h): control versus IL-12. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
20 M8978 Genes up-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468]: untreated versus GW1929 [PubChem=6518171]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
21 M5394 Genes up-regulated in comparison of macrophages stimulated with LPS (TLR4 agonist) at 4 h versus neutrophils stimulated with LPS (TLR4 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
22 M9970 Genes down-regulated in CD8A [GeneID=925] dendritic cells with IFNAR1 [GeneID=3454] knockout: control versus primary acute viral infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
23 M7489 Genes up-regulated in NCAM+ [GeneID=4684] NK cells: SELL bright [GeneID=6402] versus SELL dim [GeneID=6402]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
24 M5560 Genes down-regulated in comparison of basophils versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
25 M9039 Genes down-regulated in macrophages with knockout of HDAC3 [GeneID=8841]: heterozygous versus homozygous. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
26 M9288 Genes down-regulated in Lung dendritic cell from Ad5 infection wildtype mice versus Lung dendritic cell from Ad5 inf IL-1R mice. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
27 M8705 Genes up-regulated in bone marrow-derived macrophages with heterozygous MLL4 [GeneID=9757] knockout: control versus treated with LPS for 4h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
28 M6030 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (48h) versus IL4 [GeneID=3565] (48h). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
29 M6243 Genes down-regulated in thymocytes: double negative versus CD4 [GeneID=920] single positive. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
30 M8264 Genes up-regulated in B lymphocytes stimulated by anti-IgM: 3h versus 16h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
31 M3690 Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with LPS (TLR4 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
32 M5157 Genes up-regulated in comparison of macrophages versus macrophages exposed to L.donovani. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
33 M6000 Genes down-regulated in macrophages with SOCS3 [GeneID=9021]: untreated versus IL6 [GeneID=3569] for 100min. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
34 M6558 Genes up-regulated in monocyte-derived dendritic cells: untreated versus rosiglitazone and AM580 [PubChem=77999;2126]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
35 M9614 Genes up-regulated in T reg: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.870E-2
2.030E-1
1.000E0
 2 200
36 M1185 Genes down-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing aberrant mitosis and necrosis after treatment wiht 4 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.116E-3 3.891E-2
2.752E-1
1.000E0
 1 7
37 18722011-SuppTable2d Human Leukemia Sanchez-Guijo08 08genes GeneSigDB 2.418E-3 4.327E-2
3.060E-1
1.000E0
 1 8
38 17295094-GeneList Human Breast VandenEynden07 269genes-hypoxia angiogenesis GeneSigDB 2.603E-3 4.535E-2
3.208E-1
1.000E0
 2 263
39 M2357 Genes up-regulated in hearts of E18.5 embryos upon knockout of VEGFA [GeneID=7422]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.720E-3 4.617E-2
3.266E-1
1.000E0
 1 9
Show 34 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 246 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 6 input genes in category / 61 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11059 MODULE 150 Ttranslation elongation. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.116E-5 1.901E-3 8.927E-3 1.901E-3 2 15
2 M5900 GCM BAG5 Neighborhood of BAG5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.074E-4 6.325E-3 2.970E-2 1.265E-2 2 38
3 M18480 MODULE 159 Translation regulation. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.449E-4 1.921E-2
9.023E-2
5.764E-2
 2 81
4 M5805 GCM UBE2N Neighborhood of UBE2N MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.412E-3 2.761E-2
1.297E-1
2.082E-1
 2 155
5 M10555 GCM GSPT1 Neighborhood of GSPT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.950E-3 2.761E-2
1.297E-1
2.410E-1
 2 167
6 M7181 MORF PPP1CA Neighborhood of PPP1CA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.044E-3 2.761E-2
1.297E-1
2.467E-1
 2 169
7 M2457 GCM MLL Neighborhood of MLL MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.233E-3 2.761E-2
1.297E-1
2.582E-1
 2 173
8 M8150 GCM MYST2 Neighborhood of MYST2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.233E-3 2.761E-2
1.297E-1
2.582E-1
 2 173
9 M2731 GCM RAB10 Neighborhood of RAB10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.378E-3 2.761E-2
1.297E-1
2.671E-1
 2 176
10 M18803 MORF RAD23B Neighborhood of RAD23B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.526E-3 2.761E-2
1.297E-1
2.761E-1
 2 179
11 M19325 MORF PSMC1 Neighborhood of PSMC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.086E-3 2.820E-2
1.324E-1
3.102E-1
 2 190
12 M7466 MODULE 32 Genes in the cancer module 32. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.080E-3 4.108E-2
1.929E-1
4.929E-1
 2 241
Show 7 more annotations

16: MicroRNA [Display Chart] 7 input genes in category / 406 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-556-5p:PITA hsa-miR-556-5p:PITA TOP PITA 2.029E-7 8.237E-5 5.424E-4 8.237E-5 3 131
2 ACTGCAG,MIR-17-3P:MSigDB ACTGCAG,MIR-17-3P:MSigDB MSigDB 3.966E-5 8.051E-3
5.301E-2
 1.610E-2 2 100
3 hsa-miR-429:Functional MTI Functional MTI miRTarbase 9.052E-5 1.206E-2
7.940E-2
 3.675E-2 2 151
4 hsa-miR-767-3p:PITA hsa-miR-767-3p:PITA TOP PITA 1.816E-4 1.206E-2
7.940E-2
7.374E-2
 2 214
5 hsa-miR-1272:PITA hsa-miR-1272:PITA TOP PITA 1.919E-4 1.206E-2
7.940E-2
7.793E-2
 2 220
6 hsa-miR-18b-5p:TargetScan hsa-miR-18b-5p TargetScan 2.079E-4 1.206E-2
7.940E-2
8.441E-2
 2 229
7 hsa-miR-18a-5p:TargetScan hsa-miR-18a-5p TargetScan 2.079E-4 1.206E-2
7.940E-2
8.441E-2
 2 229
8 hsa-miR-542-3p:TargetScan hsa-miR-542-3p TargetScan 2.637E-4 1.327E-2
8.740E-2
1.071E-1
 2 258
9 hsa-miR-488-3p:TargetScan hsa-miR-488-3p TargetScan 3.703E-4 1.327E-2
8.740E-2
1.504E-1
 2 306
10 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 3.849E-4 1.327E-2
8.740E-2
1.563E-1
 2 312
11 AAGCCAT,MIR-135A:MSigDB AAGCCAT,MIR-135A:MSigDB MSigDB 3.923E-4 1.327E-2
8.740E-2
1.593E-1
 2 315
12 AAGCCAT,MIR-135B:MSigDB AAGCCAT,MIR-135B:MSigDB MSigDB 3.923E-4 1.327E-2
8.740E-2
1.593E-1
 2 315
13 hsa-miR-1276:PITA hsa-miR-1276:PITA TOP PITA 4.647E-4 1.423E-2
9.373E-2
1.887E-1
 2 343
14 hsa-miR-214*:mirSVR highEffct hsa-miR-214*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.996E-4 1.423E-2
9.373E-2
2.435E-1
 2 390
15 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 6.399E-4 1.423E-2
9.373E-2
2.598E-1
 2 403
16 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 6.979E-4 1.423E-2
9.373E-2
2.833E-1
 2 421
17 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 6.979E-4 1.423E-2
9.373E-2
2.833E-1
 2 421
18 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 6.979E-4 1.423E-2
9.373E-2
2.833E-1
 2 421
19 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 7.012E-4 1.423E-2
9.373E-2
2.847E-1
 2 422
20 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 7.012E-4 1.423E-2
9.373E-2
2.847E-1
 2 422
21 hsa-miR-4757-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.750E-4 1.448E-2
9.537E-2
3.146E-1
 1 8
22 hsa-miR-1305:PITA hsa-miR-1305:PITA TOP PITA 8.070E-4 1.448E-2
9.537E-2
3.276E-1
 2 453
23 hsa-miR-1277:mirSVR lowEffct hsa-miR-1277:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.247E-4 1.448E-2
9.537E-2
3.348E-1
 2 458
24 hsa-miR-424-5p:Functional MTI Functional MTI miRTarbase 8.717E-4 1.448E-2
9.537E-2
3.539E-1
 2 471
25 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 9.050E-4 1.448E-2
9.537E-2
3.674E-1
 2 480
26 hsa-miR-138-5p:TargetScan hsa-miR-138-5p TargetScan 9.275E-4 1.448E-2
9.537E-2
3.766E-1
 2 486
27 hsa-miR-4671-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.646E-3 2.475E-2
1.630E-1
6.683E-1
 1 17
28 hsa-miR-184:TargetScan hsa-miR-184 TargetScan 1.743E-3 2.527E-2
1.664E-1
7.076E-1
 1 18
29 hsa-miR-574-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.613E-3 3.582E-2
2.359E-1
1.000E0
 1 27
30 CACGTTT,MIR-302A:MSigDB CACGTTT,MIR-302A:MSigDB MSigDB 2.807E-3 3.582E-2
2.359E-1
1.000E0
 1 29
31 hsa-miR-744-5p:TargetScan hsa-miR-744-5p TargetScan 3.000E-3 3.582E-2
2.359E-1
1.000E0
 1 31
32 hsa-miR-208b:PITA hsa-miR-208b:PITA TOP PITA 3.000E-3 3.582E-2
2.359E-1
1.000E0
 1 31
33 hsa-miR-4800-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.000E-3 3.582E-2
2.359E-1
1.000E0
 1 31
34 hsa-miR-208a:PITA hsa-miR-208a:PITA TOP PITA 3.000E-3 3.582E-2
2.359E-1
1.000E0
 1 31
35 hsa-miR-574-3p:PITA hsa-miR-574-3p:PITA TOP PITA 3.097E-3 3.592E-2
2.365E-1
1.000E0
 1 32
36 hsa-miR-6816-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 3.593E-2
2.366E-1
1.000E0
 1 35
37 hsa-miR-24-1-5p:Functional MTI Functional MTI miRTarbase 3.483E-3 3.593E-2
2.366E-1
1.000E0
 1 36
38 hsa-miR-625-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.773E-3 3.593E-2
2.366E-1
1.000E0
 1 39
39 hsa-miR-5195-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.593E-2
2.366E-1
1.000E0
 1 40
40 hsa-miR-5089-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.256E-3 3.593E-2
2.366E-1
1.000E0
 1 44
41 hsa-miR-4713-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.449E-3 3.593E-2
2.366E-1
1.000E0
 1 46
42 hsa-miR-4474-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.449E-3 3.593E-2
2.366E-1
1.000E0
 1 46
43 hsa-miR-3138:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.546E-3 3.593E-2
2.366E-1
1.000E0
 1 47
44 hsa-miR-200c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-3 3.593E-2
2.366E-1
1.000E0
 1 50
45 hsa-miR-5681b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.593E-2
2.366E-1
1.000E0
 1 53
46 hsa-miR-6755-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.593E-2
2.366E-1
1.000E0
 1 53
47 hsa-miR-1322:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.593E-2
2.366E-1
1.000E0
 1 53
48 hsa-miR-638:Functional MTI Functional MTI miRTarbase 5.125E-3 3.593E-2
2.366E-1
1.000E0
 1 53
49 hsa-miR-6806-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.593E-2
2.366E-1
1.000E0
 1 54
50 hsa-miR-5094:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.593E-2
2.366E-1
1.000E0
 1 55
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1842 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000656932 OH-H Stitch 1.160E-12 1.779E-9 1.441E-8 2.136E-9 5 53
2 CID004634040 AC1NDZBW Stitch 1.932E-12 1.779E-9 1.441E-8 3.559E-9 6 187
3 CID000123015 AC1L3VO5 Stitch 6.452E-11 3.961E-8 3.207E-7 1.188E-7 5 116
4 CID000443071 C11105 Stitch 1.698E-8 7.822E-6 6.332E-5 3.129E-5 4 109
5 CID000000977 oxygen Stitch 9.881E-8 3.640E-5 2.947E-4 1.820E-4 5 499
6 CID000160754 RI-331 Stitch 2.841E-7 8.723E-5 7.062E-4 5.234E-4 3 47
7 CID005357439 1 SRE Stitch 3.433E-7 9.034E-5 7.314E-4 6.324E-4 3 50
8 CID000002318 benfluorex Stitch 5.399E-7 1.243E-4 1.006E-3 9.945E-4 3 58
9 CID000066393 estradiol-2,3-quinone Stitch 1.722E-6 3.525E-4 2.854E-3 3.172E-3 3 85
10 ctd:C034269 tetraethylenepentamine CTD 9.641E-6 1.776E-3 1.438E-2 1.776E-2 2 16
11 CID000148191 NSC-683864 Stitch 1.315E-5 2.202E-3 1.783E-2 2.422E-2 3 167
12 ctd:D010433 Pentylenetetrazole CTD 2.289E-5 3.337E-3 2.701E-2 4.217E-2 3 201
13 CID000151069 AC1L45LU Stitch 2.428E-5 3.337E-3 2.701E-2 4.473E-2 3 205
14 CID000000994 phenylalanine Stitch 2.536E-5 3.337E-3 2.701E-2 4.671E-2 3 208
15 CID000006326 vinylene Stitch 4.133E-5 5.076E-3 4.109E-2
7.613E-2
 3 245
16 CID000000768 cyanide Stitch 4.602E-5 5.298E-3 4.290E-2
8.477E-2
 3 254
17 CID009543495 2d3z Stitch 6.564E-5 7.112E-3
5.758E-2
1.209E-1
 2 41
18 ctd:D000666 Amphotericin B CTD 7.920E-5 8.105E-3
6.562E-2
1.459E-1
 2 45
19 CID003080614 oxalylglycine Stitch 1.143E-4 1.108E-2
8.974E-2
2.106E-1
 2 54
20 ctd:D007464 Clioquinol CTD 1.509E-4 1.390E-2
1.125E-1
2.780E-1
 2 62
21 CID009549278 K00051 Stitch 1.981E-4 1.711E-2
1.385E-1
3.648E-1
 2 71
22 CID006437867 D dB Stitch 2.330E-4 1.711E-2
1.385E-1
4.292E-1
 2 77
23 CID000004561 AC1L1IFV Stitch 2.453E-4 1.711E-2
1.385E-1
4.518E-1
 2 79
24 ctd:C006995 2-chloroethyl isocyanate CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
25 ctd:C119788 dodecaborate CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
26 ctd:C048923 crystal violet lactone CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
27 DB08263 N-(CARBOXYCARBONYL)-D-PHENYLALANINE Drug Bank 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
28 CID000068571 2FEE2 Stitch 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
29 ctd:C000536 cyclohexylisocyanate CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
30 ctd:C077304 glutathione glycylethyl ester CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
31 ctd:D064800 Prolyl-Hydroxylase Inhibitors CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
32 ctd:C431648 peptide 5F CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
33 ctd:C533794 EZN 2968 CTD 3.065E-4 1.711E-2
1.385E-1
5.645E-1
 1 1
34 ctd:D020888 Vigabatrin CTD 3.399E-4 1.814E-2
1.469E-1
6.260E-1
 2 93
35 CID000005519 TPEN Stitch 3.928E-4 1.814E-2
1.469E-1
7.236E-1
 2 100
36 CID000444218 AC1L9FY1 Stitch 4.007E-4 1.814E-2
1.469E-1
7.381E-1
 2 101
37 CID000002788 clioquinol Stitch 5.101E-4 1.814E-2
1.469E-1
9.397E-1
 2 114
38 ctd:C080890 terpestacin CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
39 ctd:C000588561 tris(4-methyl-1-pyrazolyl)borohydride CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
40 ctd:D004448 Echinomycin CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
41 ctd:C098734 carbobenzoxy-leucyl-leucyl-leucine CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
42 DB08687 N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE Drug Bank 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
43 CID000128527 CCI-103F Stitch 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
44 ctd:C478783 ZM323881 CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
45 ctd:D002614 Chelating Agents CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
46 ctd:C521309 cobalt(II) acetate CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
47 CID000199094 SA-8 Stitch 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
48 CID005315865 3'-O-acetylhamaudol Stitch 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
49 ctd:C017139 1-(2-chloroethyl)-1-nitrosourea CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
50 ctd:D057846 Cell-Penetrating Peptides CTD 6.129E-4 1.814E-2
1.469E-1
1.000E0
 1 2
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 394 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0032461 Polycythemia DisGeNET Curated 1.106E-8 4.359E-6 2.857E-5 4.359E-6 4 70
2 C0019562 Von Hippel-Lindau Syndrome DisGeNET Curated 8.287E-8 1.632E-5 1.070E-4 3.265E-5 4 115
3 C0238284 Acute mountain sickness DisGeNET BeFree 8.781E-6 1.153E-3 7.559E-3 3.460E-3 2 11
4 C1860224 ABLEPHARON-MACROSTOMIA SYNDROME DisGeNET Curated 2.726E-5 2.170E-3 1.422E-2 1.074E-2 2 19
5 C0279702 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Curated 2.754E-5 2.170E-3 1.422E-2 1.085E-2 4 493
6 C0206734 Hemangioblastoma DisGeNET Curated 1.500E-4 9.851E-3
6.457E-2
5.910E-2
 2 44
7 C0031511 Pheochromocytoma DisGeNET Curated 1.751E-4 9.856E-3
6.461E-2
6.899E-2
 3 283
8 C0749557 toe necrosis DisGeNET BeFree 4.320E-4 1.702E-2
1.116E-1
1.702E-1
 1 1
9 C1960396 Epidermal growth factor receptor negative non-small cell lung cancer DisGeNET BeFree 4.320E-4 1.702E-2
1.116E-1
1.702E-1
 1 1
10 C0265807 Acyanotic congenital heart disease DisGeNET BeFree 4.320E-4 1.702E-2
1.116E-1
1.702E-1
 1 1
11 C0585129 Retroperitoneal sarcoma DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
12 C0751552 Malignant neoplasm of thymus DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
13 C3695318 Chronic kidney disease due to hypertension DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
14 C0302872 MYELOMA, ENDOTHELIAL DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
15 C0002351 Altitude Sickness DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
16 C0442887 Septal hypertrophy DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
17 C3887514 Chromophobe carcinoma DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
18 C4045968 Altitude Hypoxia DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
19 C0342245 Diabetic oculopathy DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
20 C0206653 Angiomyoma DisGeNET BeFree 1.295E-3 2.552E-2
1.673E-1
5.104E-1
 1 3
21 C2931852 Clear-cell metastatic renal cell carcinoma DisGeNET Curated 1.470E-3 2.722E-2
1.784E-1
5.793E-1
 2 138
22 C0342951 Hypervitaminosis DisGeNET BeFree 1.727E-3 2.722E-2
1.784E-1
6.804E-1
 1 4
23 C0032320 Pneumoperitoneum DisGeNET BeFree 1.727E-3 2.722E-2
1.784E-1
6.804E-1
 1 4
24 C0268146 Glucose-6-phosphate transport defect DisGeNET Curated 1.727E-3 2.722E-2
1.784E-1
6.804E-1
 1 4
25 C0879257 Hereditary Papillary Renal Carcinoma DisGeNET BeFree 1.727E-3 2.722E-2
1.784E-1
6.804E-1
 1 4
26 C0085119 Foot Ulcer DisGeNET BeFree 2.158E-3 2.833E-2
1.857E-1
8.503E-1
 1 5
27 C0342257 Complications of Diabetes Mellitus DisGeNET Curated 2.158E-3 2.833E-2
1.857E-1
8.503E-1
 1 5
28 C0752308 Hypoxia-Ischemia, Brain DisGeNET Curated 2.158E-3 2.833E-2
1.857E-1
8.503E-1
 1 5
29 C0577698 Exercise-induced angina DisGeNET BeFree 2.158E-3 2.833E-2
1.857E-1
8.503E-1
 1 5
30 C1861906 Breast Cancer, Familial Male DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
31 C1336078 Papillary renal cell carcinoma, sporadic DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
32 C0267370 Angiodysplasia of colon DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
33 C0085411 Angiodysplasia DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
34 C0154051 Hemangioma of retina DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
35 C0151970 Ulcer of esophagus DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
36 C0238246 Hemangioma of liver DisGeNET BeFree 2.589E-3 2.833E-2
1.857E-1
1.000E0
 1 6
37 C1456822 Claudication (finding) DisGeNET BeFree 3.020E-3 2.833E-2
1.857E-1
1.000E0
 1 7
38 C0272183 Qualitative abnormality of granulocyte DisGeNET BeFree 3.020E-3 2.833E-2
1.857E-1
1.000E0
 1 7
39 C0206725 Subependymal Glioma DisGeNET BeFree 3.020E-3 2.833E-2
1.857E-1
1.000E0
 1 7
40 C4054891 Grade III Chondrosarcoma DisGeNET BeFree 3.020E-3 2.833E-2
1.857E-1
1.000E0
 1 7
41 C0040761 Transposition of Great Vessels DisGeNET Curated 3.020E-3 2.833E-2
1.857E-1
1.000E0
 1 7
42 C0268494 Oculocutaneous albinism type 1 DisGeNET Curated 3.020E-3 2.833E-2
1.857E-1
1.000E0
 1 7
43 C0346010 Multiple fibrofolliculomas DisGeNET Curated 3.451E-3 2.956E-2
1.938E-1
1.000E0
 1 8
44 C0920715 myocardial hypoxia DisGeNET BeFree 3.451E-3 2.956E-2
1.938E-1
1.000E0
 1 8
45 C1304508 Spindle cell hemangioma DisGeNET BeFree 3.451E-3 2.956E-2
1.938E-1
1.000E0
 1 8
46 C0149781 Spontaneous pneumothorax DisGeNET Curated 3.451E-3 2.956E-2
1.938E-1
1.000E0
 1 8
47 C0279674 Small cell carcinoma of the cervix DisGeNET BeFree 3.882E-3 3.186E-2
2.089E-1
1.000E0
 1 9
48 C0431406 Asymmetric crying face association DisGeNET Curated 3.882E-3 3.186E-2
2.089E-1
1.000E0
 1 9
49 C1834523 ARTHROGRYPOSIS, DISTAL, TYPE 2B DisGeNET Curated 4.312E-3 3.199E-2
2.097E-1
1.000E0
 1 10
50 C0038505 Sturge-Weber Syndrome DisGeNET Curated 4.312E-3 3.199E-2
2.097E-1
1.000E0
 1 10
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