Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc51_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 29 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004977 melanocortin receptor activity 3.692E-10 1.071E-8 4.242E-8 1.071E-8 3 6
2 GO:0004980 melanocyte-stimulating hormone receptor activity 2.584E-7 3.747E-6 1.484E-5 7.494E-6 2 3
3 GO:0008528 G protein-coupled peptide receptor activity 6.813E-6 5.284E-5 2.093E-4 1.976E-4 3 132
4 GO:0001653 peptide receptor activity 7.289E-6 5.284E-5 2.093E-4 2.114E-4 3 135
5 GO:0042923 neuropeptide binding 2.173E-5 1.260E-4 4.993E-4 6.302E-4 2 23
6 GO:0005184 neuropeptide hormone activity 4.529E-5 2.189E-4 8.672E-4 1.313E-3 2 33
7 GO:0017046 peptide hormone binding 8.477E-5 3.512E-4 1.391E-3 2.458E-3 2 45
8 GO:0042562 hormone binding 2.898E-4 1.036E-3 4.104E-3 8.404E-3 2 83
9 GO:0004978 corticotropin receptor activity 3.215E-4 1.036E-3 4.104E-3 9.324E-3 1 1
10 GO:0005179 hormone activity 6.456E-4 1.872E-3 7.418E-3 1.872E-2 2 124
11 GO:0070996 type 1 melanocortin receptor binding 9.643E-4 2.330E-3 9.232E-3 2.797E-2 1 3
12 GO:0050682 AF-2 domain binding 9.643E-4 2.330E-3 9.232E-3 2.797E-2 1 3
13 GO:0031782 type 4 melanocortin receptor binding 1.286E-3 2.485E-3 9.847E-3 3.728E-2 1 4
14 GO:0031779 melanocortin receptor binding 1.286E-3 2.485E-3 9.847E-3 3.728E-2 1 4
15 GO:0031781 type 3 melanocortin receptor binding 1.286E-3 2.485E-3 9.847E-3 3.728E-2 1 4
16 GO:0003708 retinoic acid receptor activity 2.249E-3 4.076E-3 1.615E-2
6.522E-2
 1 7
17 GO:0042277 peptide binding 3.188E-3 5.439E-3 2.155E-2
9.247E-2
 2 278
18 GO:0033218 amide binding 3.923E-3 6.321E-3 2.504E-2
1.138E-1
 2 309
19 GO:0071855 neuropeptide receptor binding 9.927E-3 1.515E-2
6.003E-2
2.879E-1
 1 31
20 GO:0008188 neuropeptide receptor activity 1.470E-2 2.105E-2
8.340E-2
4.263E-1
 1 46
21 GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding 1.597E-2 2.105E-2
8.340E-2
4.632E-1
 1 50
22 GO:0004879 nuclear receptor activity 1.597E-2 2.105E-2
8.340E-2
4.632E-1
 1 50
23 GO:0003707 steroid hormone receptor activity 1.882E-2 2.373E-2
9.402E-2
5.459E-1
 1 59
24 GO:0005496 steroid binding 3.267E-2 3.947E-2
1.564E-1
9.474E-1
 1 103
Show 19 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 145 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060259 regulation of feeding behavior 9.185E-8 1.332E-5 7.401E-5 1.332E-5 3 32
2 GO:0050795 regulation of behavior 1.630E-6 1.148E-4 6.380E-4 2.364E-4 3 82
3 GO:0007218 neuropeptide signaling pathway 3.642E-6 1.148E-4 6.380E-4 5.281E-4 3 107
4 GO:1900373 positive regulation of purine nucleotide biosynthetic process 3.959E-6 1.148E-4 6.380E-4 5.740E-4 3 110
5 GO:0030810 positive regulation of nucleotide biosynthetic process 3.959E-6 1.148E-4 6.380E-4 5.740E-4 3 110
6 GO:0006171 cAMP biosynthetic process 6.103E-6 1.287E-4 7.153E-4 8.849E-4 3 127
7 GO:0007631 feeding behavior 7.333E-6 1.287E-4 7.153E-4 1.063E-3 3 135
8 GO:0045981 positive regulation of nucleotide metabolic process 8.357E-6 1.287E-4 7.153E-4 1.212E-3 3 141
9 GO:1900544 positive regulation of purine nucleotide metabolic process 8.357E-6 1.287E-4 7.153E-4 1.212E-3 3 141
10 GO:1900371 regulation of purine nucleotide biosynthetic process 1.006E-5 1.287E-4 7.153E-4 1.459E-3 3 150
11 GO:0030808 regulation of nucleotide biosynthetic process 1.027E-5 1.287E-4 7.153E-4 1.489E-3 3 151
12 GO:0052652 cyclic purine nucleotide metabolic process 1.132E-5 1.287E-4 7.153E-4 1.642E-3 3 156
13 GO:0009190 cyclic nucleotide biosynthetic process 1.154E-5 1.287E-4 7.153E-4 1.673E-3 3 157
14 GO:0046058 cAMP metabolic process 1.244E-5 1.289E-4 7.163E-4 1.804E-3 3 161
15 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1.857E-5 1.795E-4 9.975E-4 2.692E-3 3 184
16 GO:0009187 cyclic nucleotide metabolic process 2.603E-5 2.359E-4 1.311E-3 3.775E-3 3 206
17 GO:1900542 regulation of purine nucleotide metabolic process 3.479E-5 2.967E-4 1.649E-3 5.045E-3 3 227
18 GO:0006140 regulation of nucleotide metabolic process 3.858E-5 3.108E-4 1.727E-3 5.594E-3 3 235
19 GO:0009152 purine ribonucleotide biosynthetic process 4.922E-5 3.756E-4 2.088E-3 7.137E-3 3 255
20 GO:0006164 purine nucleotide biosynthetic process 5.275E-5 3.802E-4 2.113E-3 7.649E-3 3 261
21 GO:0009260 ribonucleotide biosynthetic process 5.708E-5 3.802E-4 2.113E-3 8.277E-3 3 268
22 GO:0046390 ribose phosphate biosynthetic process 5.966E-5 3.802E-4 2.113E-3 8.650E-3 3 272
23 GO:0072522 purine-containing compound biosynthetic process 6.031E-5 3.802E-4 2.113E-3 8.745E-3 3 273
24 GO:0009165 nucleotide biosynthetic process 9.764E-5 5.822E-4 3.235E-3 1.416E-2 3 321
25 GO:1901293 nucleoside phosphate biosynthetic process 1.004E-4 5.822E-4 3.235E-3 1.455E-2 3 324
26 GO:0006112 energy reserve metabolic process 4.479E-4 2.498E-3 1.388E-2
6.494E-2
 2 103
27 GO:0042309 homoiothermy 6.443E-4 3.460E-3 1.923E-2
9.342E-2
 1 2
28 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1.036E-3 5.365E-3 2.982E-2
1.502E-1
 2 157
29 GO:2000852 regulation of corticosterone secretion 1.288E-3 6.441E-3 3.580E-2
1.868E-1
 1 4
30 GO:0035934 corticosterone secretion 1.610E-3 7.359E-3 4.090E-2
2.335E-1
 1 5
31 GO:2000821 regulation of grooming behavior 1.610E-3 7.359E-3 4.090E-2
2.335E-1
 1 5
32 GO:0008217 regulation of blood pressure 1.624E-3 7.359E-3 4.090E-2
2.355E-1
 2 197
33 GO:0007623 circadian rhythm 1.912E-3 8.403E-3 4.670E-2
2.773E-1
 2 214
34 GO:0009755 hormone-mediated signaling pathway 2.186E-3 9.322E-3
5.181E-2
3.170E-1
 2 229
35 GO:2000253 positive regulation of feeding behavior 2.575E-3 1.067E-2
5.929E-2
3.734E-1
 1 8
36 GO:0032868 response to insulin 2.935E-3 1.182E-2
6.571E-2
4.256E-1
 2 266
37 GO:2000849 regulation of glucocorticoid secretion 3.218E-3 1.252E-2
6.956E-2
4.666E-1
 1 10
38 GO:0015980 energy derivation by oxidation of organic compounds 3.385E-3 1.252E-2
6.956E-2
4.908E-1
 2 286
39 GO:0035933 glucocorticoid secretion 3.539E-3 1.252E-2
6.956E-2
5.132E-1
 1 11
40 GO:0008343 adult feeding behavior 3.539E-3 1.252E-2
6.956E-2
5.132E-1
 1 11
41 GO:0002024 diet induced thermogenesis 3.539E-3 1.252E-2
6.956E-2
5.132E-1
 1 11
42 GO:1990845 adaptive thermogenesis 3.860E-3 1.333E-2
7.407E-2
5.598E-1
 1 12
43 GO:2000252 negative regulation of feeding behavior 4.182E-3 1.410E-2
7.836E-2
6.063E-1
 1 13
44 GO:0046879 hormone secretion 5.224E-3 1.692E-2
9.402E-2
7.574E-1
 2 357
45 GO:0045475 locomotor rhythm 5.465E-3 1.692E-2
9.402E-2
7.925E-1
 1 17
46 GO:2000846 regulation of corticosteroid hormone secretion 5.465E-3 1.692E-2
9.402E-2
7.925E-1
 1 17
47 GO:0048511 rhythmic process 5.483E-3 1.692E-2
9.402E-2
7.951E-1
 2 366
48 GO:0009914 hormone transport 5.601E-3 1.692E-2
9.403E-2
8.121E-1
 2 370
49 GO:0035930 corticosteroid hormone secretion 5.786E-3 1.693E-2
9.411E-2
8.390E-1
 1 18
50 GO:0048871 multicellular organismal homeostasis 5.839E-3 1.693E-2
9.411E-2
8.467E-1
 2 378
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 11 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005782 peroxisomal matrix 1.502E-2 4.609E-2
1.392E-1
1.652E-1
 1 48
2 GO:0031907 microbody lumen 1.502E-2 4.609E-2
1.392E-1
1.652E-1
 1 48
3 GO:0034774 secretory granule lumen 2.646E-2 4.609E-2
1.392E-1
2.911E-1
 1 85
4 GO:0044439 peroxisomal part 2.984E-2 4.609E-2
1.392E-1
3.283E-1
 1 96
5 GO:0005796 Golgi lumen 2.984E-2 4.609E-2
1.392E-1
3.283E-1
 1 96
6 GO:0044438 microbody part 2.984E-2 4.609E-2
1.392E-1
3.283E-1
 1 96
7 GO:0060205 cytoplasmic vesicle lumen 3.230E-2 4.609E-2
1.392E-1
3.553E-1
 1 104
8 GO:0031983 vesicle lumen 3.352E-2 4.609E-2
1.392E-1
3.687E-1
 1 108
9 GO:0005777 peroxisome 4.388E-2 4.827E-2
1.458E-1
4.827E-1
 1 142
10 GO:0042579 microbody 4.388E-2 4.827E-2
1.458E-1
4.827E-1
 1 142
Show 5 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 73 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012337 Abnormal homeostasis 6.527E-7 1.588E-5 7.742E-5 4.765E-5 3 20
2 HP:0012338 Abnormal energy expenditure 6.527E-7 1.588E-5 7.742E-5 4.765E-5 3 20
3 HP:0012340 Decreased resting energy expenditure 6.527E-7 1.588E-5 7.742E-5 4.765E-5 3 20
4 HP:0008915 Childhood-onset truncal obesity 9.017E-6 1.646E-4 8.022E-4 6.583E-4 2 5
5 HP:0009126 Increased adipose tissue 4.049E-5 5.912E-4 2.882E-3 2.956E-3 2 10
6 HP:0001513 Obesity 3.018E-4 3.270E-3 1.594E-2 2.203E-2 4 424
7 HP:0009025 Increased connective tissue 3.136E-4 3.270E-3 1.594E-2 2.289E-2 2 27
8 HP:0004324 Increased body weight 4.087E-4 3.729E-3 1.818E-2 2.983E-2 4 458
9 HP:0000956 Acanthosis nigricans 6.586E-4 5.058E-3 2.466E-2 4.808E-2 2 39
10 HP:0002591 Polyphagia 6.929E-4 5.058E-3 2.466E-2
5.058E-2
 2 40
11 HP:0100738 Abnormal eating behavior 1.041E-3 6.907E-3 3.367E-2
7.597E-2
 2 49
12 HP:0001956 Truncal obesity 1.664E-3 1.012E-2 4.935E-2
1.215E-1
 2 62
13 HP:0040202 Abnormal consumption behavior 3.637E-3 2.042E-2
9.955E-2
2.655E-1
 2 92
14 HP:0000842 Hyperinsulinemia 6.433E-3 3.029E-2
1.476E-1
4.696E-1
 2 123
15 HP:0040215 Abnormal circulating insulin level 6.639E-3 3.029E-2
1.476E-1
4.846E-1
 2 125
16 HP:0040214 Abnormal insulin level 6.639E-3 3.029E-2
1.476E-1
4.846E-1
 2 125
17 HP:0002297 Red hair 1.058E-2 4.544E-2
2.215E-1
7.725E-1
 1 10
Show 12 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 340 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001261 obese 1.652E-7 5.617E-5 3.599E-4 5.617E-5 4 108
2 MP:0005449 abnormal food intake 1.113E-6 1.893E-4 1.213E-3 3.786E-4 5 472
3 MP:0005667 abnormal circulating leptin level 3.147E-6 2.485E-4 1.592E-3 1.070E-3 4 225
4 MP:0010024 increased total body fat amount 3.376E-6 2.485E-4 1.592E-3 1.148E-3 4 229
5 MP:0005658 increased susceptibility to diet-induced obesity 3.654E-6 2.485E-4 1.592E-3 1.242E-3 3 60
6 MP:0005450 abnormal energy expenditure 4.867E-6 2.638E-4 1.690E-3 1.655E-3 4 251
7 MP:0005448 abnormal energy homeostasis 5.431E-6 2.638E-4 1.690E-3 1.846E-3 4 258
8 MP:0011117 abnormal susceptibility to weight gain 6.319E-6 2.685E-4 1.721E-3 2.148E-3 4 268
9 MP:0004890 decreased energy expenditure 9.411E-6 3.555E-4 2.278E-3 3.200E-3 3 82
10 MP:0005661 decreased circulating adrenaline level 1.535E-5 4.818E-4 3.087E-3 5.220E-3 2 11
11 MP:0001260 increased body weight 1.824E-5 4.818E-4 3.087E-3 6.201E-3 4 350
12 MP:0012323 increased total tissue mass 1.824E-5 4.818E-4 3.087E-3 6.201E-3 4 350
13 MP:0009302 increased renal fat pad weight 1.842E-5 4.818E-4 3.087E-3 6.263E-3 2 12
14 MP:0001264 increased body size 2.885E-5 6.589E-4 4.222E-3 9.809E-3 4 393
15 MP:0005455 increased susceptibility to weight gain 3.034E-5 6.589E-4 4.222E-3 1.032E-2 3 121
16 MP:0005669 increased circulating leptin level 3.265E-5 6.589E-4 4.222E-3 1.110E-2 3 124
17 MP:0011957 decreased compensatory feeding amount 3.346E-5 6.589E-4 4.222E-3 1.138E-2 2 16
18 MP:0001748 increased circulating adrenocorticotropin level 3.791E-5 6.589E-4 4.222E-3 1.289E-2 2 17
19 MP:0011940 decreased food intake 4.119E-5 6.589E-4 4.222E-3 1.401E-2 3 134
20 MP:0008294 abnormal adrenal gland zona fasciculata morphology 4.263E-5 6.589E-4 4.222E-3 1.450E-2 2 18
21 MP:0003374 decreased circulating mineralocorticoid level 4.263E-5 6.589E-4 4.222E-3 1.450E-2 2 18
22 MP:0002667 decreased circulating aldosterone level 4.263E-5 6.589E-4 4.222E-3 1.450E-2 2 18
23 MP:0005457 abnormal percent body fat/body weight 5.545E-5 8.197E-4 5.252E-3 1.885E-2 3 148
24 MP:0011956 abnormal compensatory feeding amount 5.847E-5 8.284E-4 5.308E-3 1.988E-2 2 21
25 MP:0005660 abnormal circulating adrenaline level 6.430E-5 8.485E-4 5.437E-3 2.186E-2 2 22
26 MP:0011479 abnormal catecholamine level 6.489E-5 8.485E-4 5.437E-3 2.206E-2 3 156
27 MP:0011939 increased food intake 7.533E-5 9.325E-4 5.975E-3 2.561E-2 3 164
28 MP:0005129 increased adrenocorticotropin level 7.679E-5 9.325E-4 5.975E-3 2.611E-2 2 24
29 MP:0008902 abnormal renal fat pad morphology 8.345E-5 9.783E-4 6.269E-3 2.837E-2 2 25
30 MP:0005288 abnormal oxygen consumption 1.205E-4 1.365E-3 8.748E-3 4.096E-2 3 192
31 MP:0003962 abnormal adrenaline level 1.466E-4 1.607E-3 1.030E-2 4.983E-2 2 33
32 MP:0002665 decreased circulating corticosterone level 1.847E-4 1.820E-3 1.166E-2
6.279E-2
 2 37
33 MP:0002079 increased circulating insulin level 1.904E-4 1.820E-3 1.166E-2
6.473E-2
 3 224
34 MP:0002204 abnormal neurotransmitter level 1.929E-4 1.820E-3 1.166E-2
6.559E-2
 3 225
35 MP:0002768 small adrenal glands 1.949E-4 1.820E-3 1.166E-2
6.626E-2
 2 38
36 MP:0003368 decreased circulating glucocorticoid level 1.949E-4 1.820E-3 1.166E-2
6.626E-2
 2 38
37 MP:0009115 abnormal fat cell morphology 1.980E-4 1.820E-3 1.166E-2
6.733E-2
 3 227
38 MP:0003966 abnormal adrenocorticotropin level 2.271E-4 2.032E-3 1.302E-2
7.723E-2
 2 41
39 MP:0003372 abnormal circulating mineralocorticoid level 2.500E-4 2.125E-3 1.362E-2
8.500E-2
 2 43
40 MP:0005346 abnormal circulating aldosterone level 2.500E-4 2.125E-3 1.362E-2
8.500E-2
 2 43
41 MP:0000010 abnormal abdominal fat pad morphology 2.730E-4 2.264E-3 1.450E-2
9.281E-2
 3 253
42 MP:0011415 abnormal aldosterone level 3.251E-4 2.632E-3 1.686E-2
1.105E-1
 2 49
43 MP:0008288 abnormal adrenal cortex morphology 3.386E-4 2.677E-3 1.715E-2
1.151E-1
 2 50
44 MP:0005334 abnormal fat pad morphology 4.602E-4 3.556E-3 2.278E-2
1.565E-1
 3 302
45 MP:0005475 abnormal circulating thyroxine level 5.551E-4 4.182E-3 2.680E-2
1.888E-1
 2 64
46 MP:0005458 increased percent body fat/body weight 5.726E-4 4.182E-3 2.680E-2
1.947E-1
 2 65
47 MP:0013565 abnormal adrenal gland capsule morphology 5.794E-4 4.182E-3 2.680E-2
1.970E-1
 1 1
48 MP:0009116 abnormal brown fat cell morphology 5.904E-4 4.182E-3 2.680E-2
2.007E-1
 2 66
49 MP:0005469 abnormal thyroxine level 7.024E-4 4.776E-3 3.060E-2
2.388E-1
 2 72
50 MP:0001433 polyphagia 7.024E-4 4.776E-3 3.060E-2
2.388E-1
 2 72
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 39 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001671 Melcrt ACTH rcpt InterPro 3.649E-10 1.423E-8 6.053E-8 1.423E-8 3 6
2 IPR001908 Melancort rcpt InterPro 2.564E-7 5.000E-6 2.127E-5 9.999E-6 2 3
3 SM01381 7TM GPCR Srsx SMART 4.106E-6 5.337E-5 2.270E-4 1.601E-4 3 112
4 SM01365 Op neuropeptide SMART 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
5 SM01363 ACTH domain SMART 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
6 IPR000155 Mcort rcpt 4 InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
7 IPR001168 ACTH rcpt InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
8 PF00976 ACTH domain Pfam 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
9 IPR013532 Opioid neuropept InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
10 PF08384 NPP Pfam 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
11 IPR013593 Melanocortin N InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
12 IPR002122 Mcort 3 rcpt InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
13 IPR001941 Mcortin ACTH InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
14 PF08035 Op neuropeptide Pfam 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
15 IPR013531 Mcrtin ACTH cent InterPro 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
16 SM01364 NPP SMART 3.203E-4 7.806E-4 3.320E-3 1.249E-2 1 1
17 IPR027300 Agouti dom InterPro 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
18 4.10.760.10 - Gene3D 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
19 IPR007733 Agouti InterPro 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
20 PS60024 AGOUTI 1 PROSITE 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
21 PS51150 AGOUTI 2 PROSITE 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
22 PF05039 Agouti Pfam 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
23 SM00792 Agouti SMART 6.404E-4 1.086E-3 4.619E-3 2.498E-2 1 2
24 IPR027289 Oest-rel rcp InterPro 9.605E-4 1.561E-3 6.639E-3 3.746E-2 1 3
25 IPR003078 Retinoic acid rcpt InterPro 1.281E-3 1.998E-3 8.497E-3 4.994E-2 1 4
26 IPR024178 Oest rcpt/oest-rel rcp InterPro 1.600E-3 2.401E-3 1.021E-2
6.242E-2
 1 5
27 IPR000003 Retinoid-X rcpt/HNF4 InterPro 3.199E-3 4.620E-3 1.965E-2
1.247E-1
 1 10
28 PS00031 NUCLEAR REC DBD 1 PROSITE 1.464E-2 1.610E-2
6.849E-2
5.711E-1
 1 46
29 IPR001628 Znf hrmn rcpt InterPro 1.464E-2 1.610E-2
6.849E-2
5.711E-1
 1 46
30 IPR001723 Nuclear hrmn rcpt InterPro 1.464E-2 1.610E-2
6.849E-2
5.711E-1
 1 46
31 PF00105 zf-C4 Pfam 1.464E-2 1.610E-2
6.849E-2
5.711E-1
 1 46
32 PS51030 NUCLEAR REC DBD 2 PROSITE 1.464E-2 1.610E-2
6.849E-2
5.711E-1
 1 46
33 SM00399 ZnF C4 SMART 1.464E-2 1.610E-2
6.849E-2
5.711E-1
 1 46
34 1.10.565.10 - Gene3D 1.496E-2 1.610E-2
6.849E-2
5.834E-1
 1 47
35 IPR000536 Nucl hrmn rcpt lig-bd InterPro 1.528E-2 1.610E-2
6.849E-2
5.958E-1
 1 48
36 SM00430 HOLI SMART 1.528E-2 1.610E-2
6.849E-2
5.958E-1
 1 48
37 PF00104 Hormone recep Pfam 1.528E-2 1.610E-2
6.849E-2
5.958E-1
 1 48
38 3.30.50.10 - Gene3D 1.812E-2 1.843E-2
7.841E-2
7.066E-1
 1 57
39 IPR013088 Znf NHR/GATA InterPro 1.843E-2 1.843E-2
7.841E-2
7.189E-1
 1 58
Show 34 more annotations

7: Pathway [Display Chart] 6 input genes in category / 35 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000366 altered melanocortin system Pathway Ontology 6.218E-10 2.176E-8 9.024E-8 2.176E-8 3 5
2 PW:0000540 obesity disease Pathway Ontology 3.480E-9 6.090E-8 2.525E-7 1.218E-7 3 8
3 PW:0000365 melanocortin system Pathway Ontology 7.454E-9 8.697E-8 3.606E-7 2.609E-7 3 10
4 137952 Syndecan-3-mediated signaling events BioSystems: Pathway Interaction Database 4.219E-8 3.691E-7 1.531E-6 1.477E-6 3 17
5 1269004 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) BioSystems: REACTOME 1.936E-7 1.355E-6 5.619E-6 6.775E-6 2 2
6 1269575 G alpha (s) signalling events BioSystems: REACTOME 2.673E-7 1.560E-6 6.467E-6 9.357E-6 4 146
7 1269546 Peptide ligand-binding receptors BioSystems: REACTOME 7.379E-7 3.689E-6 1.530E-5 2.583E-5 4 188
8 PW:0000359 altered energy homeostasis Pathway Ontology 1.934E-6 7.523E-6 3.119E-5 6.770E-5 2 5
9 SMP00310 Corticotropin Activation of Cortisol Production SMPDB 1.934E-6 7.523E-6 3.119E-5 6.770E-5 2 5
10 1268977 Metabolic disorders of biological oxidation enzymes BioSystems: REACTOME 2.901E-6 1.015E-5 4.210E-5 1.015E-4 2 6
11 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 6.324E-6 2.012E-5 8.344E-5 2.213E-4 4 322
12 1269544 GPCR ligand binding BioSystems: REACTOME 2.491E-5 7.266E-5 3.013E-4 8.719E-4 4 455
13 1268939 Diseases of metabolism BioSystems: REACTOME 1.899E-4 5.112E-4 2.120E-3 6.645E-3 2 45
14 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 2.096E-4 5.239E-4 2.173E-3 7.335E-3 3 278
15 83093 Adipocytokine signaling pathway BioSystems: KEGG 4.476E-4 1.044E-3 4.331E-3 1.567E-2 2 69
16 1270048 Glucocorticoid biosynthesis BioSystems: REACTOME 4.330E-3 9.473E-3 3.928E-2
1.516E-1
 1 9
17 1270050 Androgen biosynthesis BioSystems: REACTOME 5.291E-3 1.089E-2 4.517E-2
1.852E-1
 1 11
18 1268753 Peptide hormone biosynthesis BioSystems: REACTOME 6.729E-3 1.308E-2
5.426E-2
2.355E-1
 1 14
19 1270192 Endogenous sterols BioSystems: REACTOME 1.342E-2 2.332E-2
9.671E-2
4.697E-1
 1 28
20 1269585 G-protein activation BioSystems: REACTOME 1.390E-2 2.332E-2
9.671E-2
4.864E-1
 1 29
21 P04380 Cortocotropin releasing factor receptor signaling pathway PantherDB 1.437E-2 2.332E-2
9.671E-2
5.031E-1
 1 30
22 1270046 Metabolism of steroid hormones BioSystems: REACTOME 1.533E-2 2.332E-2
9.671E-2
5.364E-1
 1 32
23 P05917 Opioid proopiomelanocortin pathway PantherDB 1.533E-2 2.332E-2
9.671E-2
5.364E-1
 1 32
24 1269652 Nuclear Receptor transcription pathway BioSystems: REACTOME 2.433E-2 3.549E-2
1.472E-1
8.516E-1
 1 51
25 1270191 Cytochrome P450 - arranged by substrate type BioSystems: REACTOME 3.327E-2 4.658E-2
1.932E-1
1.000E0
 1 70
Show 20 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1722 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18551113 Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns. Pubmed 2.538E-15 3.399E-12 2.729E-11 4.370E-12 4 6
2 9058374 Effects of recombinant agouti-signaling protein on melanocortin action. Pubmed 5.922E-15 3.399E-12 2.729E-11 1.020E-11 4 7
3 15597110 Melanocortin-4 receptor gene and physical activity in the Québec Family Study. Pubmed 5.922E-15 3.399E-12 2.729E-11 1.020E-11 4 7
4 10321434 Rodent mutant models of obesity and their correlations to human obesity. Pubmed 2.132E-14 9.177E-12 7.368E-11 3.671E-11 4 9
5 17041250 The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. Pubmed 2.154E-12 4.637E-10 3.723E-9 3.709E-9 3 3
6 21544212 Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice. Pubmed 2.154E-12 4.637E-10 3.723E-9 3.709E-9 3 3
7 11747427 High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein. Pubmed 2.154E-12 4.637E-10 3.723E-9 3.709E-9 3 3
8 15927146 Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness. Pubmed 2.154E-12 4.637E-10 3.723E-9 3.709E-9 3 3
9 26226973 Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians. Pubmed 8.616E-12 1.349E-9 1.083E-8 1.484E-8 3 4
10 28426141 Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8(+) T Cytotoxic Lymphocytes and CD19(+) B Lymphocytes in Rheumatoid Arthritis Responding to TNF-α Inhibition. Pubmed 8.616E-12 1.349E-9 1.083E-8 1.484E-8 3 4
11 19743876 Novel binding motif of ACTH analogues at the melanocortin receptors. Pubmed 8.616E-12 1.349E-9 1.083E-8 1.484E-8 3 4
12 8185570 Molecular cloning, expression, and characterization of a fifth melanocortin receptor. Pubmed 2.154E-11 2.853E-9 2.291E-8 3.709E-8 3 5
13 12865302 Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. Pubmed 2.154E-11 2.853E-9 2.291E-8 3.709E-8 3 5
14 14962995 Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Pubmed 4.307E-11 5.298E-9 4.254E-8 7.417E-8 3 6
15 12620396 The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Pubmed 7.538E-11 7.635E-9 6.130E-8 1.298E-7 3 7
16 19329486 MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Pubmed 7.538E-11 7.635E-9 6.130E-8 1.298E-7 3 7
17 19570576 Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice. Pubmed 7.538E-11 7.635E-9 6.130E-8 1.298E-7 3 7
18 9763877 Agouti/melanocortin interactions with leptin pathways in obesity. Pubmed 1.206E-10 1.093E-8 8.775E-8 2.077E-7 3 8
19 7949735 Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Pubmed 1.206E-10 1.093E-8 8.775E-8 2.077E-7 3 8
20 12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. Pubmed 1.547E-10 1.332E-8 1.070E-7 2.664E-7 4 70
21 18162531 A model for obesity and gigantism due to disruption of the Ankrd26 gene. Pubmed 1.809E-10 1.483E-8 1.191E-7 3.115E-7 3 9
22 23197713 BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior. Pubmed 7.836E-10 6.133E-8 4.924E-7 1.349E-6 3 14
23 19058789 A common variant in DRD3 receptor is associated with autism spectrum disorder. Pubmed 1.853E-9 1.387E-7 1.114E-6 3.191E-6 4 129
24 19737523 A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Pubmed 4.948E-9 3.550E-7 2.850E-6 8.520E-6 3 25
25 20468064 Association study of 182 candidate genes in anorexia nervosa. Pubmed 7.428E-9 5.116E-7 4.108E-6 1.279E-5 4 182
26 19077438 Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Pubmed 8.732E-9 5.208E-7 4.182E-6 1.504E-5 3 30
27 21363936 Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
28 15642615 Meal patterns and foraging in melanocortin receptor knockout mice. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
29 16459314 A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
30 15256492 Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
31 10973258 Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
32 10318826 Contribution of melanocortin receptor exoloops to Agouti-related protein binding. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
33 17545153 Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
34 11101306 Molecular determinants of ligand binding to the human melanocortin-4 receptor. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
35 25013995 Clinical utility of plasma POMC and AgRP measurements in the differential diagnosis of ACTH-dependent Cushing's syndrome. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
36 15951321 Six novel mutations in the proopiomelanocortin and melanocortin receptor 4 genes in severely obese adults living in southern Italy. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
37 17989225 Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
38 12213892 Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
39 23007189 Unraveling the brain regulation of appetite: lessons from genetics. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
40 15034587 Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
41 22544740 Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH). Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
42 19646498 Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
43 19074037 Monitoring FoxO1 localization in chemically identified neurons. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
44 26782456 Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
45 20800636 Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
46 25446108 Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
47 16005545 Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
48 19770186 Hormone and glucose signalling in POMC and AgRP neurons. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
49 12851322 Knockout studies defining different roles for melanocortin receptors in energy homeostasis. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
50 12815165 Molecular determination of agouti-related protein binding to human melanocortin-4 receptor. Pubmed 2.057E-8 5.208E-7 4.182E-6 3.542E-5 2 2
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 73 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:POMC POMC interactions 2.191E-11 1.599E-9 7.797E-9 1.599E-9 4 21
2 int:MC3R MC3R interactions 2.163E-10 7.894E-9 3.848E-8 1.579E-8 3 5
3 int:ASIP ASIP interactions 7.568E-10 1.841E-8 8.976E-8 5.524E-8 3 7
4 int:MC4R MC4R interactions 6.179E-9 9.022E-8 4.398E-7 4.511E-7 3 13
5 int:AGRP AGRP interactions 6.179E-9 9.022E-8 4.398E-7 4.511E-7 3 13
6 int:MC5R MC5R interactions 9.569E-7 9.979E-6 4.864E-5 6.985E-5 2 5
7 int:MC2R MC2R interactions 9.569E-7 9.979E-6 4.864E-5 6.985E-5 2 5
8 int:MC1R MC1R interactions 1.461E-5 1.333E-4 6.499E-4 1.067E-3 2 18
9 int:MSX1 MSX1 interactions 4.432E-5 3.595E-4 1.752E-3 3.235E-3 2 31
10 int:MGRN1 MGRN1 interactions 1.028E-4 7.503E-4 3.658E-3 7.503E-3 2 47
11 int:ATRNL1 ATRNL1 interactions 6.778E-4 4.498E-3 2.192E-2 4.948E-2 1 2
12 int:MRAP MRAP interactions 1.016E-3 6.184E-3 3.014E-2
7.420E-2
 1 3
13 int:TTL TTL interactions 2.370E-3 1.331E-2
6.489E-2
1.730E-1
 1 7
14 int:HLF HLF interactions 3.047E-3 1.560E-2
7.605E-2
2.224E-1
 1 9
15 int:ARHGEF15 ARHGEF15 interactions 3.723E-3 1.560E-2
7.605E-2
2.718E-1
 1 11
16 int:FGF10 FGF10 interactions 3.723E-3 1.560E-2
7.605E-2
2.718E-1
 1 11
17 int:NHLRC3 NHLRC3 interactions 4.061E-3 1.560E-2
7.605E-2
2.964E-1
 1 12
18 int:GHRL GHRL interactions 4.061E-3 1.560E-2
7.605E-2
2.964E-1
 1 12
19 int:TSPAN11 TSPAN11 interactions 4.061E-3 1.560E-2
7.605E-2
2.964E-1
 1 12
20 int:NPY NPY interactions 5.411E-3 1.881E-2
9.169E-2
3.950E-1
 1 16
21 int:HLA-DRB3 HLA-DRB3 interactions 5.411E-3 1.881E-2
9.169E-2
3.950E-1
 1 16
22 int:PNRC1 PNRC1 interactions 6.423E-3 2.131E-2
1.039E-1
4.689E-1
 1 19
23 int:PNRC2 PNRC2 interactions 7.434E-3 2.269E-2
1.106E-1
5.427E-1
 1 22
24 int:MEP1A MEP1A interactions 7.771E-3 2.269E-2
1.106E-1
5.673E-1
 1 23
25 int:PROX1 PROX1 interactions 7.771E-3 2.269E-2
1.106E-1
5.673E-1
 1 23
26 int:IL1RAP IL1RAP interactions 8.444E-3 2.371E-2
1.156E-1
6.164E-1
 1 25
27 int:PPARGC1B PPARGC1B interactions 8.781E-3 2.374E-2
1.157E-1
6.410E-1
 1 26
28 int:NEUROD1 NEUROD1 interactions 1.013E-2 2.634E-2
1.284E-1
7.392E-1
 1 30
29 int:AMD1 AMD1 interactions 1.046E-2 2.634E-2
1.284E-1
7.637E-1
 1 31
30 int:SUMO1P1 SUMO1P1 interactions 1.147E-2 2.701E-2
1.317E-1
8.373E-1
 1 34
31 int:NR0B1 NR0B1 interactions 1.147E-2 2.701E-2
1.317E-1
8.373E-1
 1 34
32 int:ESRRG ESRRG interactions 1.214E-2 2.770E-2
1.350E-1
8.863E-1
 1 36
33 int:ESRRA ESRRA interactions 1.348E-2 2.983E-2
1.454E-1
9.842E-1
 1 40
34 int:SHTN1 SHTN1 interactions 1.449E-2 2.990E-2
1.458E-1
1.000E0
 1 43
35 int:SRA1 SRA1 interactions 1.449E-2 2.990E-2
1.458E-1
1.000E0
 1 43
36 int:EBP EBP interactions 1.482E-2 2.990E-2
1.458E-1
1.000E0
 1 44
37 int:ASB7 ASB7 interactions 1.516E-2 2.990E-2
1.458E-1
1.000E0
 1 45
38 int:KLHL15 KLHL15 interactions 1.583E-2 3.040E-2
1.482E-1
1.000E0
 1 47
39 int:DEUP1 DEUP1 interactions 1.883E-2 3.525E-2
1.718E-1
1.000E0
 1 56
40 int:BIRC6 BIRC6 interactions 2.183E-2 3.795E-2
1.850E-1
1.000E0
 1 65
41 int:NOTCH2 NOTCH2 interactions 2.183E-2 3.795E-2
1.850E-1
1.000E0
 1 65
42 int:NUP160 NUP160 interactions 2.183E-2 3.795E-2
1.850E-1
1.000E0
 1 65
43 int:FBLN1 FBLN1 interactions 2.283E-2 3.876E-2
1.889E-1
1.000E0
 1 68
44 int:NRIP1 NRIP1 interactions 2.349E-2 3.898E-2
1.900E-1
1.000E0
 1 70
45 int:KCTD10 KCTD10 interactions 2.449E-2 3.927E-2
1.914E-1
1.000E0
 1 73
46 int:PPARGC1A PPARGC1A interactions 2.549E-2 3.927E-2
1.914E-1
1.000E0
 1 76
47 int:NR0B2 NR0B2 interactions 2.549E-2 3.927E-2
1.914E-1
1.000E0
 1 76
48 int:GRK2 GRK2 interactions 2.582E-2 3.927E-2
1.914E-1
1.000E0
 1 77
49 int:NRDC NRDC interactions 2.781E-2 4.122E-2
2.009E-1
1.000E0
 1 83
50 int:RBL1 RBL1 interactions 2.847E-2 4.122E-2
2.009E-1
1.000E0
 1 85
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18q22 18q22 5.192E-4 3.114E-3 7.630E-3 3.115E-3 1 3
2 20q13.2-q13.3 20q13.2-q13.3 1.038E-3 3.114E-3 7.630E-3 6.230E-3 1 6
3 18p11.2 18p11.2 1.557E-3 3.114E-3 7.630E-3 9.342E-3 1 9
4 16q22 16q22 3.112E-3 4.668E-3 1.144E-2 1.867E-2 1 18
5 1q41 1q41 1.154E-2 1.189E-2 2.912E-2
6.926E-2
 1 67
6 2p23.3 2p23.3 1.189E-2 1.189E-2 2.912E-2
7.131E-2
 1 69
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 101 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 236 Melanocortin receptors genenames.org 1.992E-10 5.977E-10 1.096E-9 5.977E-10 3 5
2 542 Endogenous ligands genenames.org 2.449E-3 3.673E-3 6.734E-3 7.346E-3 2 237
3 71 Nuclear hormone receptors genenames.org 1.605E-2 1.605E-2 2.943E-2 4.816E-2 1 49

13: Coexpression [Display Chart] 6 input genes in category / 272 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 4.237E-7 1.153E-4 7.128E-4 1.153E-4 4 303
2 M4509 Genes down-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 12 h versus stimulated CD4 [GeneID=920] Th2 cells at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.698E-3 1.050E-2 3.396E-3 3 200
3 14673169-TableA1-2 Human Breast Hendricks04 64genes BRG1 down GeneSigDB 5.276E-5 4.784E-3 2.959E-2 1.435E-2 2 44
4 M7914 Genes down-regulated in ALAB cells (breast cancer) upon reintroduction of SMARCA4 [GeneID=6597] expressed off adenoviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.678E-5 5.221E-3 3.229E-2 2.088E-2 2 53
5 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 1.513E-4 8.229E-3
5.090E-2
 4.115E-2 3 462
6 M8142 Genes down-regulated in CD8 T cells: IL10+ [GeneID=3586] versus IL10- [GeneID=3586]. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 4.236E-2
2.620E-1
2.936E-1
 2 199
7 M5323 Genes up-regulated in comparison of memory CD4 [GeneID=920] T cells from young donors treated with TSST at 72 h versus those from old donors treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.236E-2
2.620E-1
2.965E-1
 2 200
Show 2 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 281 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 39 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 233 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-488-3p:Functional MTI Functional MTI miRTarbase 4.872E-5 1.135E-2
6.845E-2
 1.135E-2 2 131
2 hsa-miR-488-3p:TargetScan hsa-miR-488-3p TargetScan 2.653E-4 2.337E-2
1.409E-1
6.181E-2
 2 306
3 hsa-miR-488:PITA hsa-miR-488:PITA TOP PITA 3.009E-4 2.337E-2
1.409E-1
7.011E-2
 2 326
4 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 6.682E-4 3.114E-2
1.878E-1
1.557E-1
 2 487
5 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 6.682E-4 3.114E-2
1.878E-1
1.557E-1
 2 487
6 hsa-miR-139-3p:PITA hsa-miR-139-3p:PITA TOP PITA 1.743E-3 3.479E-2
2.098E-1
4.061E-1
 1 21
7 hsa-miR-375:PITA hsa-miR-375:PITA TOP PITA 2.158E-3 3.479E-2
2.098E-1
5.027E-1
 1 26
8 hsa-miR-409-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 3.479E-2
2.098E-1
5.993E-1
 1 31
9 hsa-miR-487a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.152E-3 3.479E-2
2.098E-1
7.344E-1
 1 38
10 hsa-miR-487b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 3.479E-2
2.098E-1
7.730E-1
 1 40
11 GCAAGAC,MIR-431:MSigDB GCAAGAC,MIR-431:MSigDB MSigDB 3.566E-3 3.479E-2
2.098E-1
8.309E-1
 1 43
12 hsa-miR-5580-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.228E-3 3.479E-2
2.098E-1
9.852E-1
 1 51
13 hsa-miR-616-3p:Functional MTI Functional MTI miRTarbase 4.394E-3 3.479E-2
2.098E-1
1.000E0
 1 53
14 CTAGGAA,MIR-384:MSigDB CTAGGAA,MIR-384:MSigDB MSigDB 4.973E-3 3.479E-2
2.098E-1
1.000E0
 1 60
15 hsa-miR-6815-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 3.479E-2
2.098E-1
1.000E0
 1 61
16 hsa-miR-499a-5p:Functional MTI Functional MTI miRTarbase 5.304E-3 3.479E-2
2.098E-1
1.000E0
 1 64
17 hsa-miR-659-3p:Functional MTI Functional MTI miRTarbase 5.635E-3 3.479E-2
2.098E-1
1.000E0
 1 68
18 AGTCTTA,MIR-499:MSigDB AGTCTTA,MIR-499:MSigDB MSigDB 5.883E-3 3.479E-2
2.098E-1
1.000E0
 1 71
19 AATGGAG,MIR-136:MSigDB AATGGAG,MIR-136:MSigDB MSigDB 5.965E-3 3.479E-2
2.098E-1
1.000E0
 1 72
20 hsa-miR-6852-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.296E-3 3.479E-2
2.098E-1
1.000E0
 1 76
21 hsa-miR-6760-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.626E-3 3.479E-2
2.098E-1
1.000E0
 1 80
22 hsa-miR-103a-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.709E-3 3.479E-2
2.098E-1
1.000E0
 1 81
23 hsa-miR-3909:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.709E-3 3.479E-2
2.098E-1
1.000E0
 1 81
24 hsa-miR-4470:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.791E-3 3.479E-2
2.098E-1
1.000E0
 1 82
25 hsa-miR-769-5p:PITA hsa-miR-769-5p:PITA TOP PITA 6.874E-3 3.479E-2
2.098E-1
1.000E0
 1 83
26 hsa-miR-133b:Functional MTI Functional MTI miRTarbase 6.957E-3 3.479E-2
2.098E-1
1.000E0
 1 84
27 hsa-miR-376c-3p:Functional MTI Functional MTI miRTarbase 6.957E-3 3.479E-2
2.098E-1
1.000E0
 1 84
28 AGGTGCA,MIR-500:MSigDB AGGTGCA,MIR-500:MSigDB MSigDB 7.369E-3 3.479E-2
2.098E-1
1.000E0
 1 89
29 hsa-miR-2115-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.700E-3 3.479E-2
2.098E-1
1.000E0
 1 93
30 hsa-miR-5587-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.700E-3 3.479E-2
2.098E-1
1.000E0
 1 93
31 hsa-miR-8087:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 3.479E-2
2.098E-1
1.000E0
 1 94
32 hsa-miR-431:PITA hsa-miR-431:PITA TOP PITA 7.782E-3 3.479E-2
2.098E-1
1.000E0
 1 94
33 hsa-miR-4432:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.479E-2
2.098E-1
1.000E0
 1 98
34 GGTGTGT,MIR-329:MSigDB GGTGTGT,MIR-329:MSigDB MSigDB 8.525E-3 3.479E-2
2.098E-1
1.000E0
 1 103
35 hsa-miR-139-3p:mirSVR highEffct hsa-miR-139-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.525E-3 3.479E-2
2.098E-1
1.000E0
 1 103
36 hsa-miR-483-3p:PITA hsa-miR-483-3p:PITA TOP PITA 8.937E-3 3.479E-2
2.098E-1
1.000E0
 1 108
37 hsa-miR-676-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.102E-3 3.479E-2
2.098E-1
1.000E0
 1 110
38 hsa-miR-99a*:mirSVR highEffct hsa-miR-99a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.514E-3 3.479E-2
2.098E-1
1.000E0
 1 115
39 hsa-miR-4492:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.843E-3 3.479E-2
2.098E-1
1.000E0
 1 119
40 hsa-miR-4498:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.843E-3 3.479E-2
2.098E-1
1.000E0
 1 119
41 hsa-miR-5001-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.843E-3 3.479E-2
2.098E-1
1.000E0
 1 119
42 ACAGGGT,MIR-10B:MSigDB ACAGGGT,MIR-10B:MSigDB MSigDB 9.926E-3 3.479E-2
2.098E-1
1.000E0
 1 120
43 hsa-miR-935:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.926E-3 3.479E-2
2.098E-1
1.000E0
 1 120
44 ACTGTAG,MIR-139:MSigDB ACTGTAG,MIR-139:MSigDB MSigDB 9.926E-3 3.479E-2
2.098E-1
1.000E0
 1 120
45 ACAGGGT,MIR-10A:MSigDB ACAGGGT,MIR-10A:MSigDB MSigDB 9.926E-3 3.479E-2
2.098E-1
1.000E0
 1 120
46 hsa-miR-762:Functional MTI Functional MTI miRTarbase 1.017E-2 3.479E-2
2.098E-1
1.000E0
 1 123
47 GTGCAAA,MIR-507:MSigDB GTGCAAA,MIR-507:MSigDB MSigDB 1.058E-2 3.479E-2
2.098E-1
1.000E0
 1 128
48 hsa-miR-1258:PITA hsa-miR-1258:PITA TOP PITA 1.075E-2 3.479E-2
2.098E-1
1.000E0
 1 130
49 hsa-miR-99b*:mirSVR highEffct hsa-miR-99b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.075E-2 3.479E-2
2.098E-1
1.000E0
 1 130
50 hsa-miR-133a-3p:Functional MTI Functional MTI miRTarbase 1.075E-2 3.479E-2
2.098E-1
1.000E0
 1 130
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1829 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006440621 Shu 9119 Stitch 7.616E-15 1.393E-11 1.127E-10 1.393E-11 5 26
2 CID003010021 His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Stitch 1.984E-14 1.815E-11 1.468E-10 3.629E-11 4 6
3 CID000160744 Acth (6-9) Stitch 4.629E-14 2.822E-11 2.283E-10 8.467E-11 4 7
4 CID005326858 4-amino 5-hydroxy pentanoic acid Stitch 6.663E-14 3.046E-11 2.464E-10 1.219E-10 5 39
5 CID005487257 Haatpln Stitch 1.666E-13 6.096E-11 4.931E-10 3.048E-10 4 9
6 CID000125672 Lys-pro-val Stitch 2.777E-13 7.854E-11 6.353E-10 5.079E-10 4 10
7 CID000092432 melanotan II Stitch 3.006E-13 7.854E-11 6.353E-10 5.498E-10 5 52
8 CID005311279 His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2 Stitch 4.364E-13 9.977E-11 8.070E-10 7.981E-10 4 11
9 CID005287594 A-A-U Stitch 6.315E-13 1.283E-10 1.038E-9 1.155E-9 5 60
10 CID000132380 Bim 22015 Stitch 9.453E-13 1.729E-10 1.399E-9 1.729E-9 4 13
11 CID000130595 Hp 228 Stitch 3.146E-12 5.231E-10 4.231E-9 5.754E-9 4 17
12 CID011841000 6-Formyltetrahydropterin Stitch 5.123E-12 7.808E-10 6.316E-9 9.369E-9 4 19
13 CID005748175 4pal Stitch 6.403E-12 9.008E-10 7.287E-9 1.171E-8 4 20
14 CID000123787 Acth (4-10) Stitch 7.909E-12 1.033E-9 8.358E-9 1.446E-8 4 21
15 CID003037130 Acth(11-24) Stitch 9.665E-12 1.179E-9 9.533E-9 1.768E-8 4 22
16 CID000002145 aminoglutethimide Stitch 4.307E-11 4.924E-9 3.983E-8 7.878E-8 5 137
17 CID000005928 embitol Stitch 1.007E-10 1.083E-8 8.763E-8 1.842E-7 3 5
18 CID000003337 fenfluramine Stitch 1.620E-10 1.646E-8 1.332E-7 2.963E-7 5 178
19 CID006325610 melanin Stitch 5.522E-10 5.316E-8 4.300E-7 1.010E-6 5 227
20 CID003080858 lysine salicylate Stitch 8.455E-10 7.732E-8 6.255E-7 1.546E-6 3 9
21 CID000132857 L-368,899 Stitch 1.660E-9 1.446E-7 1.170E-6 3.037E-6 3 11
22 CID000000076 ITdU Stitch 1.960E-9 1.629E-7 1.318E-6 3.584E-6 5 292
23 CID000094326 Yellow pigment Stitch 2.189E-9 1.741E-7 1.408E-6 4.004E-6 4 81
24 CID000018465 dhpta Stitch 6.041E-9 4.604E-7 3.724E-6 1.105E-5 4 104
25 CID000541493 aspartyl-phenylalanine Stitch 7.038E-9 5.003E-7 4.047E-6 1.287E-5 4 108
26 CID000005753 corticosterone Stitch 7.446E-9 5.003E-7 4.047E-6 1.362E-5 5 381
27 CID000006166 deoxycorticosterone Stitch 7.864E-9 5.003E-7 4.047E-6 1.438E-5 4 111
28 CID000023961 thulium Stitch 7.864E-9 5.003E-7 4.047E-6 1.438E-5 4 111
29 CID000000129 isocaproaldehyde Stitch 8.206E-9 5.003E-7 4.047E-6 1.501E-5 3 18
30 CID000123993 Acth 4-9 Stitch 8.206E-9 5.003E-7 4.047E-6 1.501E-5 3 18
31 CID000053657 P-F-H Stitch 9.744E-9 5.749E-7 4.650E-6 1.782E-5 3 19
32 CID000002753 cilostamide Stitch 1.078E-8 6.161E-7 4.984E-6 1.972E-5 4 120
33 CID004478051 AC1NAJM8 Stitch 1.735E-8 9.576E-7 7.746E-6 3.173E-5 4 135
34 CID006451163 PT 141 Stitch 1.780E-8 9.576E-7 7.746E-6 3.256E-5 3 23
35 CID000016157 PL 0 Stitch 2.034E-8 1.063E-6 8.599E-6 3.721E-5 3 24
36 ctd:C103272 SHU 9119 CTD 5.751E-8 2.843E-6 2.299E-5 1.052E-4 2 2
37 CID000009005 trimethoxymethane Stitch 5.751E-8 2.843E-6 2.299E-5 1.052E-4 2 2
38 CID000004736 pentazocine HCl Stitch 6.008E-8 2.892E-6 2.339E-5 1.099E-4 3 34
39 CID000122313 Pyr-his-gly Stitch 6.571E-8 3.082E-6 2.493E-5 1.202E-4 3 35
40 CID003035793 AH 21-132 Stitch 7.799E-8 3.530E-6 2.856E-5 1.427E-4 3 37
41 CID000002193 AC1Q6O8T Stitch 7.943E-8 3.530E-6 2.856E-5 1.453E-4 4 197
42 CID000449606 AC1L9NAZ Stitch 8.107E-8 3.530E-6 2.856E-5 1.483E-4 4 198
43 CID000040065 Iodogen Stitch 1.328E-7 5.651E-6 4.571E-5 2.430E-4 3 44
44 CID000008894 tetrahydropyran Stitch 1.423E-7 5.916E-6 4.786E-5 2.603E-4 3 45
45 CID000001027 3 -hydroxypregn-5-en-20-one Stitch 1.696E-7 6.859E-6 5.548E-5 3.103E-4 4 238
46 CID002724878 A804090 Stitch 1.725E-7 6.859E-6 5.548E-5 3.155E-4 2 3
47 CID000036523 Factrel Stitch 1.937E-7 7.536E-6 6.096E-5 3.542E-4 4 246
48 CID000123795 Deltorphin Ii Stitch 2.486E-7 9.471E-6 7.661E-5 4.546E-4 3 54
49 CID000005244 dehydroepiandrosterone sulfate Stitch 3.115E-7 1.163E-5 9.406E-5 5.698E-4 4 277
50 CID006918812 MB243 Stitch 3.450E-7 1.262E-5 1.021E-4 6.309E-4 2 4
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 421 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:601665 OBESITY OMIM 3.813E-11 1.605E-8 1.063E-7 1.605E-8 4 22
2 cv:C0028754 Obesity Clinical Variations 1.577E-8 3.319E-6 2.197E-5 6.637E-6 3 16
3 C0028756 Obesity, Morbid DisGeNET Curated 2.875E-8 4.035E-6 2.672E-5 1.210E-5 4 109
4 C0342541 Precocious pubarche DisGeNET Curated 5.692E-8 5.991E-6 3.966E-5 2.396E-5 3 24
5 C1857854 Proopiomelanocortin Deficiency DisGeNET Curated 1.142E-7 8.016E-6 5.308E-5 4.810E-5 2 2
6 C0009426 Combat Disorders DisGeNET BeFree 1.142E-7 8.016E-6 5.308E-5 4.810E-5 2 2
7 C4024583 Fat tissue increased DisGeNET Curated 3.427E-7 1.803E-5 1.194E-4 1.443E-4 2 3
8 C1859846 Truncal obesity apparent in childhood DisGeNET Curated 3.427E-7 1.803E-5 1.194E-4 1.443E-4 2 3
9 C0497406 Overweight DisGeNET Curated 6.651E-7 2.885E-5 1.910E-4 2.800E-4 4 238
10 C1955743 Mineralocorticoid deficiency DisGeNET BeFree 6.853E-7 2.885E-5 1.910E-4 2.885E-4 2 4
11 C2609247 Adrenal incidentaloma DisGeNET BeFree 1.142E-6 4.370E-5 2.894E-4 4.807E-4 2 5
12 C2362324 Pediatric Obesity DisGeNET Curated 1.530E-6 5.366E-5 3.553E-4 6.440E-4 3 70
13 C0003125 Anorexia Nervosa DisGeNET Curated 2.380E-6 7.209E-5 4.773E-4 1.002E-3 3 81
14 C0267990 Adult-onset obesity DisGeNET BeFree 2.397E-6 7.209E-5 4.773E-4 1.009E-3 2 7
15 C4054476 Monogenic Obesity DisGeNET BeFree 3.196E-6 8.970E-5 5.939E-4 1.345E-3 2 8
16 C0342546 Premature adrenarche DisGeNET Curated 4.108E-6 1.017E-4 6.736E-4 1.730E-3 2 9
17 C2675519 Hypoadiponectinemia DisGeNET BeFree 4.108E-6 1.017E-4 6.736E-4 1.730E-3 2 9
18 C0003123 Anorexia DisGeNET Curated 4.499E-6 1.052E-4 6.968E-4 1.894E-3 3 100
19 C0271742 Glucocorticoid deficiency with achalasia DisGeNET Curated 5.134E-6 1.081E-4 7.156E-4 2.162E-3 2 10
20 C0543698 hypersensitive syndrome DisGeNET BeFree 5.134E-6 1.081E-4 7.156E-4 2.162E-3 2 10
21 C1859974 GLUCOCORTICOID DEFICIENCY 1 DisGeNET Curated 6.274E-6 1.258E-4 8.328E-4 2.642E-3 2 11
22 C0005910 Body Weight DisGeNET Curated 1.038E-5 1.899E-4 1.258E-3 4.368E-3 2 14
23 C1955741 Glucocorticoid deficiency DisGeNET BeFree 1.038E-5 1.899E-4 1.258E-3 4.368E-3 2 14
24 C3178789 Widespread Chronic Pain DisGeNET BeFree 1.197E-5 2.100E-4 1.390E-3 5.040E-3 2 15
25 C1857451 Acth-Independent Macronodular Adrenal Hyperplasia DisGeNET Curated 1.948E-5 3.281E-4 2.172E-3 8.202E-3 2 19
26 C0020595 Hypoaldosteronism DisGeNET Curated 2.392E-5 3.873E-4 2.564E-3 1.007E-2 2 21
27 C0020175 Hunger DisGeNET BeFree 2.630E-5 3.955E-4 2.619E-3 1.107E-2 2 22
28 C0006370 Bulimia DisGeNET BeFree 2.630E-5 3.955E-4 2.619E-3 1.107E-2 2 22
29 C0342492 Adrenal hypertrophy or hyperplasia DisGeNET BeFree 3.142E-5 4.561E-4 3.020E-3 1.323E-2 2 24
30 C0020505 Hyperphagia DisGeNET Curated 3.698E-5 5.023E-4 3.326E-3 1.557E-2 2 26
31 C0232461 Increased appetite (finding) DisGeNET Curated 3.698E-5 5.023E-4 3.326E-3 1.557E-2 2 26
32 C0010276 Craniopharyngioma DisGeNET Curated 3.994E-5 5.254E-4 3.479E-3 1.681E-2 2 27
33 C1621895 Adrenal hyperplasia DisGeNET Curated 4.947E-5 6.311E-4 4.179E-3 2.083E-2 2 30
34 C0001623 Adrenal gland hypofunction DisGeNET Curated 5.639E-5 6.982E-4 4.623E-3 2.374E-2 2 32
35 C1306214 ACTH-Secreting Pituitary Adenoma DisGeNET Curated 7.157E-5 8.381E-4 5.549E-3 3.013E-2 2 36
36 C0346402 Malignant neoplasm of adrenal cortex DisGeNET BeFree 7.565E-5 8.381E-4 5.549E-3 3.185E-2 2 37
37 C2267227 Bulimia Nervosa DisGeNET Curated 7.565E-5 8.381E-4 5.549E-3 3.185E-2 2 37
38 C3887898 Infantile Spasm DisGeNET Curated 7.565E-5 8.381E-4 5.549E-3 3.185E-2 2 37
39 C0020625 Hyponatremia DisGeNET Curated 7.984E-5 8.619E-4 5.707E-3 3.361E-2 2 38
40 C0001618 Tumors of Adrenal Cortex DisGeNET Curated 1.073E-4 1.130E-3 7.480E-3 4.519E-2 2 44
41 C0001627 Congenital adrenal hyperplasia DisGeNET Curated 1.174E-4 1.197E-3 7.923E-3 4.942E-2 2 46
42 C0271650 Impaired glucose tolerance DisGeNET Curated 1.242E-4 1.197E-3 7.923E-3
5.227E-2
 3 303
43 C0206081 Hyperandrogenism DisGeNET Curated 1.279E-4 1.197E-3 7.923E-3
5.385E-2
 2 48
44 C0342443 Adrenal Cushing's syndrome DisGeNET BeFree 1.279E-4 1.197E-3 7.923E-3
5.385E-2
 2 48
45 C0221406 Pituitary-dependent Cushing's disease DisGeNET Curated 1.279E-4 1.197E-3 7.923E-3
5.385E-2
 2 48
46 C0221765 Chronic schizophrenia DisGeNET Curated 1.333E-4 1.220E-3 8.079E-3
5.613E-2
 2 49
47 C0010481 Cushing Syndrome DisGeNET Curated 1.503E-4 1.346E-3 8.911E-3
6.326E-2
 2 52
48 C0020459 Hyperinsulinism DisGeNET Curated 1.556E-4 1.365E-3 9.039E-3
6.553E-2
 3 327
49 C0037769 West Syndrome DisGeNET Curated 1.807E-4 1.553E-3 1.028E-2
7.607E-2
 2 57
50 C0001403 Addison Disease DisGeNET Curated 2.425E-4 2.042E-3 1.352E-2
1.021E-1
 2 66
Show 45 more annotations