Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc53_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 9 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003729 mRNA binding 4.691E-5 4.222E-4 1.194E-3 4.222E-4 3 179
2 GO:0042162 telomeric DNA binding 1.322E-2 4.853E-2
1.373E-1
1.189E-1
 1 31
3 GO:0008536 Ran GTPase binding 1.618E-2 4.853E-2
1.373E-1
1.456E-1
 1 38
4 GO:0003730 mRNA 3'-UTR binding 2.208E-2 4.968E-2
1.405E-1
1.987E-1
 1 52

2: GO: Biological Process [Display Chart] 8 input genes in category / 69 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006406 mRNA export from nucleus 1.260E-15 4.348E-14 2.095E-13 8.696E-14 7 106
2 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 1.260E-15 4.348E-14 2.095E-13 8.696E-14 7 106
3 GO:0006405 RNA export from nucleus 3.075E-15 5.065E-14 2.441E-13 2.121E-13 7 120
4 GO:0071426 ribonucleoprotein complex export from nucleus 3.075E-15 5.065E-14 2.441E-13 2.121E-13 7 120
5 GO:0071166 ribonucleoprotein complex localization 3.670E-15 5.065E-14 2.441E-13 2.533E-13 7 123
6 GO:0051028 mRNA transport 1.592E-14 1.830E-13 8.820E-13 1.098E-12 7 151
7 GO:0050658 RNA transport 5.347E-14 4.612E-13 2.222E-12 3.689E-12 7 179
8 GO:0050657 nucleic acid transport 5.347E-14 4.612E-13 2.222E-12 3.689E-12 7 179
9 GO:0051236 establishment of RNA localization 6.018E-14 4.614E-13 2.223E-12 4.152E-12 7 182
10 GO:0051168 nuclear export 7.578E-14 5.229E-13 2.519E-12 5.229E-12 7 188
11 GO:0006403 RNA localization 1.900E-13 1.129E-12 5.442E-12 1.311E-11 7 214
12 GO:0015931 nucleobase-containing compound transport 1.964E-13 1.129E-12 5.442E-12 1.355E-11 7 215
13 GO:0006913 nucleocytoplasmic transport 6.930E-11 3.678E-10 1.772E-9 4.782E-9 7 494
14 GO:0006369 termination of RNA polymerase II transcription 7.717E-9 3.803E-8 1.833E-7 5.325E-7 4 62
15 GO:0031124 mRNA 3'-end processing 3.845E-8 1.769E-7 8.523E-7 2.653E-6 4 92
16 GO:0006353 DNA-templated transcription, termination 5.838E-8 2.518E-7 1.213E-6 4.028E-6 4 102
17 GO:0031123 RNA 3'-end processing 1.125E-7 4.459E-7 2.149E-6 7.763E-6 4 120
18 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1.163E-7 4.459E-7 2.149E-6 8.027E-6 4 121
19 GO:0000956 nuclear-transcribed mRNA catabolic process 9.091E-7 3.302E-6 1.591E-5 6.273E-5 4 202
20 GO:0006402 mRNA catabolic process 1.233E-6 4.252E-6 2.049E-5 8.505E-5 4 218
21 GO:0006401 RNA catabolic process 2.028E-6 6.662E-6 3.210E-5 1.399E-4 4 247
22 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4.689E-6 1.407E-5 6.778E-5 3.235E-4 4 305
23 GO:0000398 mRNA splicing, via spliceosome 4.689E-6 1.407E-5 6.778E-5 3.235E-4 4 305
24 GO:0000375 RNA splicing, via transesterification reactions 4.938E-6 1.420E-5 6.840E-5 3.407E-4 4 309
25 GO:0008380 RNA splicing 1.398E-5 3.859E-5 1.859E-4 9.646E-4 4 402
26 GO:0034655 nucleobase-containing compound catabolic process 1.631E-5 4.327E-5 2.085E-4 1.125E-3 4 418
27 GO:0044270 cellular nitrogen compound catabolic process 2.418E-5 6.061E-5 2.920E-4 1.668E-3 4 462
28 GO:0046700 heterocycle catabolic process 2.459E-5 6.061E-5 2.920E-4 1.697E-3 4 464
29 GO:0019439 aromatic compound catabolic process 2.675E-5 6.364E-5 3.066E-4 1.845E-3 4 474
30 GO:0006397 mRNA processing 2.787E-5 6.410E-5 3.089E-4 1.923E-3 4 479
31 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 1.010E-4 2.248E-4 1.083E-3 6.968E-3 2 36
32 GO:0000380 alternative mRNA splicing, via spliceosome 1.729E-4 3.728E-4 1.796E-3 1.193E-2 2 47
33 GO:0048024 regulation of mRNA splicing, via spliceosome 3.954E-4 8.267E-4 3.983E-3 2.728E-2 2 71
34 GO:0043484 regulation of RNA splicing 9.288E-4 1.885E-3 9.083E-3
6.409E-2
 2 109
35 GO:0050684 regulation of mRNA processing 9.630E-4 1.898E-3 9.148E-3
6.645E-2
 2 111
36 GO:0044838 cell quiescence 1.288E-3 2.456E-3 1.184E-2
8.889E-2
 1 3
37 GO:1903311 regulation of mRNA metabolic process 1.317E-3 2.456E-3 1.184E-2
9.089E-2
 2 130
38 GO:0006986 response to unfolded protein 2.342E-3 4.253E-3 2.049E-2
1.616E-1
 2 174
39 GO:0035966 response to topologically incorrect protein 2.614E-3 4.625E-3 2.229E-2
1.804E-1
 2 184
40 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 3.004E-3 5.181E-3 2.497E-2
2.073E-1
 1 7
41 GO:0016973 poly(A)+ mRNA export from nucleus 5.999E-3 1.010E-2 4.865E-2
4.140E-1
 1 14
42 GO:0022403 cell cycle phase 7.281E-3 1.196E-2
5.764E-2
5.024E-1
 1 17
43 GO:0006417 regulation of translation 9.000E-3 1.444E-2
6.959E-2
6.210E-1
 2 347
44 GO:0034248 regulation of cellular amide metabolic process 1.072E-2 1.681E-2
8.100E-2
7.396E-1
 2 380
45 GO:0048025 negative regulation of mRNA splicing, via spliceosome 1.112E-2 1.705E-2
8.213E-2
7.670E-1
 1 26
46 GO:0033119 negative regulation of RNA splicing 1.324E-2 1.986E-2
9.571E-2
9.137E-1
 1 31
47 GO:0050686 negative regulation of mRNA processing 1.579E-2 2.296E-2
1.106E-1
1.000E0
 1 37
48 GO:2000779 regulation of double-strand break repair 1.621E-2 2.296E-2
1.106E-1
1.000E0
 1 38
49 GO:0010608 posttranscriptional regulation of gene expression 1.642E-2 2.296E-2
1.106E-1
1.000E0
 2 475
50 GO:0044848 biological phase 1.663E-2 2.296E-2
1.106E-1
1.000E0
 1 39
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 14 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035145 exon-exon junction complex 1.124E-10 1.573E-9 5.115E-9 1.573E-9 4 23
2 GO:0016607 nuclear speck 6.771E-9 4.740E-8 1.541E-7 9.480E-8 5 201
3 GO:0016604 nuclear body 1.320E-7 6.160E-7 2.003E-6 1.848E-6 5 364
4 GO:0005643 nuclear pore 5.282E-4 1.697E-3 5.518E-3 7.394E-3 2 84
5 GO:0071013 catalytic step 2 spliceosome 6.060E-4 1.697E-3 5.518E-3 8.484E-3 2 90
6 GO:0061574 ASAP complex 1.259E-3 2.937E-3 9.549E-3 1.762E-2 1 3
7 GO:0005681 spliceosomal complex 2.212E-3 4.425E-3 1.439E-2 3.097E-2 2 173
8 GO:0042405 nuclear inclusion body 5.026E-3 8.469E-3 2.754E-2
7.037E-2
 1 12
9 GO:0000346 transcription export complex 5.444E-3 8.469E-3 2.754E-2
7.622E-2
 1 13
10 GO:0005635 nuclear envelope 1.441E-2 2.018E-2
6.561E-2
2.018E-1
 2 454
11 GO:0016234 inclusion body 3.064E-2 3.900E-2
1.268E-1
4.290E-1
 1 74
Show 6 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 132 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 116 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 8 input genes in category / 54 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR018222 Nuclear transport factor 2 euk InterPro 4.462E-6 7.743E-5 3.543E-4 2.409E-4 2 8
2 PF02136 NTF2 Pfam 4.462E-6 7.743E-5 3.543E-4 2.409E-4 2 8
3 IPR002075 NTF2 InterPro 5.735E-6 7.743E-5 3.543E-4 3.097E-4 2 9
4 PS50177 NTF2 DOMAIN PROSITE 5.735E-6 7.743E-5 3.543E-4 3.097E-4 2 9
5 3.10.450.50 - Gene3D 1.242E-5 1.341E-4 6.135E-4 6.705E-4 2 13
6 IPR032710 NTF2-like dom InterPro 1.671E-5 1.504E-4 6.880E-4 9.022E-4 2 15
7 3.30.70.330 - Gene3D 1.164E-4 8.982E-4 4.110E-3 6.287E-3 3 244
8 IPR012677 Nucleotide-bd a/b plait InterPro 1.374E-4 9.271E-4 4.242E-3 7.417E-3 3 258
9 IPR007193 Up-fram suppressor-2 InterPro 4.270E-4 2.306E-3 1.055E-2 2.306E-2 1 1
10 PF04050 Upf2 Pfam 4.270E-4 2.306E-3 1.055E-2 2.306E-2 1 1
11 3.30.1560.10 - Gene3D 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
12 PS51281 TAP C PROSITE 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
13 SM00804 TAP C SMART 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
14 IPR005120 Nonsense mediated decay UPF3 InterPro 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
15 PF03467 Smg4 UPF3 Pfam 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
16 IPR005637 TAP C dom InterPro 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
17 PF03943 TAP C Pfam 8.539E-4 2.712E-3 1.241E-2 4.611E-2 1 2
18 SM00311 PWI SMART 1.281E-3 3.143E-3 1.438E-2
6.915E-2
 1 3
19 PF02792 Mago nashi Pfam 1.281E-3 3.143E-3 1.438E-2
6.915E-2
 1 3
20 IPR013822 Signal recog particl SRP54 hlx InterPro 1.281E-3 3.143E-3 1.438E-2
6.915E-2
 1 3
21 IPR004023 Mago nashi InterPro 1.281E-3 3.143E-3 1.438E-2
6.915E-2
 1 3
22 PS51025 PWI PROSITE 1.281E-3 3.143E-3 1.438E-2
6.915E-2
 1 3
23 PF09162 Tap-RNA bind Pfam 1.707E-3 3.414E-3 1.562E-2
9.218E-2
 1 4
24 PD043466 Tap RNA bd ProDom 1.707E-3 3.414E-3 1.562E-2
9.218E-2
 1 4
25 IPR014876 DEK C InterPro 1.707E-3 3.414E-3 1.562E-2
9.218E-2
 1 4
26 IPR015245 Tap RNA-bd InterPro 1.707E-3 3.414E-3 1.562E-2
9.218E-2
 1 4
27 PF08766 DEK C Pfam 1.707E-3 3.414E-3 1.562E-2
9.218E-2
 1 4
28 1.20.1390.10 - Gene3D 2.133E-3 3.840E-3 1.757E-2
1.152E-1
 1 5
29 IPR002483 PWI dom InterPro 2.133E-3 3.840E-3 1.757E-2
1.152E-1
 1 5
30 PF01480 PWI Pfam 2.133E-3 3.840E-3 1.757E-2
1.152E-1
 1 5
31 IPR000504 RRM dom InterPro 3.900E-3 6.577E-3 3.009E-2
2.106E-1
 2 227
32 PS50102 RRM PROSITE 4.002E-3 6.577E-3 3.009E-2
2.161E-1
 2 230
33 SM00543 MIF4G SMART 4.263E-3 6.577E-3 3.009E-2
2.302E-1
 1 10
34 IPR003890 MIF4G-like typ-3 InterPro 4.263E-3 6.577E-3 3.009E-2
2.302E-1
 1 10
35 PF02854 MIF4G Pfam 4.263E-3 6.577E-3 3.009E-2
2.302E-1
 1 10
36 IPR003603 U2A' phosphoprotein32A C InterPro 4.688E-3 6.842E-3 3.131E-2
2.532E-1
 1 11
37 SM00446 LRRcap SMART 4.688E-3 6.842E-3 3.131E-2
2.532E-1
 1 11
38 IPR016021 MIF4-like InterPro 6.388E-3 8.845E-3 4.047E-2
3.450E-1
 1 15
39 1.25.40.180 - Gene3D 6.388E-3 8.845E-3 4.047E-2
3.450E-1
 1 15
40 PF02037 SAP Pfam 9.357E-3 1.263E-2
5.780E-2
5.053E-1
 1 22
41 SM00513 SAP SMART 9.781E-3 1.288E-2
5.894E-2
5.282E-1
 1 23
42 IPR003034 SAP dom InterPro 1.063E-2 1.335E-2
6.106E-2
5.739E-1
 1 25
43 PS50800 SAP PROSITE 1.063E-2 1.335E-2
6.106E-2
5.739E-1
 1 25
44 IPR009060 UBA-like InterPro 2.701E-2 3.315E-2
1.517E-1
1.000E0
 1 64
Show 39 more annotations

7: Pathway [Display Chart] 8 input genes in category / 26 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 193328 mRNA surveillance pathway BioSystems: KEGG 7.009E-15 1.822E-13 7.024E-13 1.822E-13 7 91
2 177876 RNA transport BioSystems: KEGG 6.450E-13 8.385E-12 3.232E-11 1.677E-11 7 171
3 1269694 Transport of Mature mRNA derived from an Intron-Containing Transcript BioSystems: REACTOME 1.174E-12 1.017E-11 3.920E-11 3.051E-11 6 76
4 1269693 Transport of Mature Transcript to Cytoplasm BioSystems: REACTOME 2.904E-12 1.888E-11 7.276E-11 7.551E-11 6 88
5 1269688 Processing of Capped Intron-Containing Pre-mRNA BioSystems: REACTOME 1.593E-9 8.285E-9 3.194E-8 4.143E-8 6 248
6 1269692 mRNA 3'-end processing BioSystems: REACTOME 4.104E-8 1.779E-7 6.855E-7 1.067E-6 4 63
7 1269685 RNA Polymerase II Transcription Termination BioSystems: REACTOME 7.072E-8 2.298E-7 8.859E-7 1.839E-6 4 72
8 1269686 Cleavage of Growing Transcript in the Termination Region BioSystems: REACTOME 7.072E-8 2.298E-7 8.859E-7 1.839E-6 4 72
9 1269716 Nonsense-Mediated Decay (NMD) BioSystems: REACTOME 5.767E-7 1.499E-6 5.779E-6 1.499E-5 4 121
10 1269717 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) BioSystems: REACTOME 5.767E-7 1.499E-6 5.779E-6 1.499E-5 4 121
11 1269675 RNA Polymerase II Transcription BioSystems: REACTOME 1.857E-6 4.389E-6 1.692E-5 4.828E-5 4 162
12 1269690 mRNA Splicing - Major Pathway BioSystems: REACTOME 3.362E-6 7.285E-6 2.808E-5 8.742E-5 4 188
13 1269689 mRNA Splicing BioSystems: REACTOME 3.969E-6 7.939E-6 3.060E-5 1.032E-4 4 196
14 199378 Ribosome biogenesis in eukaryotes BioSystems: KEGG 1.945E-3 3.611E-3 1.392E-2
5.056E-2
 2 106
15 217173 Influenza A BioSystems: KEGG 5.088E-3 8.819E-3 3.399E-2
1.323E-1
 2 173
16 M1529 Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. MSigDB C2 BIOCARTA (v6.0) 9.601E-3 1.560E-2
6.013E-2
2.496E-1
 1 15
17 1269697 Transport of the SLBP independent Mature mRNA BioSystems: REACTOME 2.165E-2 3.218E-2
1.240E-1
5.628E-1
 1 34
18 1269696 Transport of the SLBP Dependant Mature mRNA BioSystems: REACTOME 2.228E-2 3.218E-2
1.240E-1
5.792E-1
 1 35
19 1427839 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors BioSystems: REACTOME 2.542E-2 3.479E-2
1.341E-1
6.610E-1
 1 40
20 1269698 Transport of Mature mRNA Derived from an Intronless Transcript BioSystems: REACTOME 2.793E-2 3.536E-2
1.363E-1
7.263E-1
 1 44
21 1269695 Transport of Mature mRNAs Derived from Intronless Transcripts BioSystems: REACTOME 2.856E-2 3.536E-2
1.363E-1
7.426E-1
 1 45
Show 16 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 450 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11546874 Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Pubmed 1.364E-21 6.139E-19 4.106E-18 6.139E-19 6 10
2 9933612 The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. Pubmed 4.631E-18 6.946E-16 4.645E-15 2.084E-15 5 8
3 12093754 The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. Pubmed 4.631E-18 6.946E-16 4.645E-15 2.084E-15 5 8
4 16209946 Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Pubmed 5.526E-14 6.217E-12 4.157E-11 2.487E-11 4 8
5 11707413 Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. Pubmed 6.030E-11 4.523E-9 3.025E-8 2.714E-8 3 5
6 11118221 The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. Pubmed 6.030E-11 4.523E-9 3.025E-8 2.714E-8 3 5
7 20479275 Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. Pubmed 1.206E-10 7.752E-9 5.185E-8 5.427E-8 3 6
8 11546873 Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Pubmed 2.110E-10 9.496E-9 6.350E-8 9.496E-8 3 7
9 19478851 The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. Pubmed 2.110E-10 9.496E-9 6.350E-8 9.496E-8 3 7
10 18066079 NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Pubmed 2.110E-10 9.496E-9 6.350E-8 9.496E-8 3 7
11 16601204 Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. Pubmed 3.376E-10 1.381E-8 9.236E-8 1.519E-7 3 8
12 23788676 The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Pubmed 7.233E-10 2.712E-8 1.814E-7 3.255E-7 3 10
13 20930030 SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Pubmed 9.944E-10 3.442E-8 2.302E-7 4.475E-7 3 11
14 16452507 Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Pubmed 2.193E-9 7.049E-8 4.714E-7 9.869E-7 3 14
15 12226669 Comprehensive proteomic analysis of the human spliceosome. Pubmed 4.355E-9 1.306E-7 8.736E-7 1.960E-6 4 109
16 19417104 SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Pubmed 6.864E-9 1.931E-7 1.291E-6 3.089E-6 3 20
17 20371770 AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Pubmed 2.198E-8 5.819E-7 3.891E-6 9.892E-6 3 29
18 23084401 The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Pubmed 2.554E-8 6.385E-7 4.270E-6 1.149E-5 4 169
19 25628361 The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA. Pubmed 3.839E-8 8.227E-7 5.502E-6 1.728E-5 2 2
20 11583626 Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Pubmed 3.839E-8 8.227E-7 5.502E-6 1.728E-5 2 2
21 11256625 Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. Pubmed 3.839E-8 8.227E-7 5.502E-6 1.728E-5 2 2
22 15004547 The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Pubmed 1.152E-7 2.073E-6 1.386E-5 5.182E-5 2 3
23 17333237 XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1. Pubmed 1.152E-7 2.073E-6 1.386E-5 5.182E-5 2 3
24 12718880 Y14 and hUpf3b form an NMD-activating complex. Pubmed 1.152E-7 2.073E-6 1.386E-5 5.182E-5 2 3
25 11579093 RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex. Pubmed 1.152E-7 2.073E-6 1.386E-5 5.182E-5 2 3
26 22203037 Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Pubmed 2.303E-7 3.343E-6 2.236E-5 1.036E-4 2 4
27 19503078 A UPF3-mediated regulatory switch that maintains RNA surveillance. Pubmed 2.303E-7 3.343E-6 2.236E-5 1.036E-4 2 4
28 14730019 eIF4A3 is a novel component of the exon junction complex. Pubmed 2.303E-7 3.343E-6 2.236E-5 1.036E-4 2 4
29 11113196 Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Pubmed 2.303E-7 3.343E-6 2.236E-5 1.036E-4 2 4
30 14729961 RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Pubmed 2.303E-7 3.343E-6 2.236E-5 1.036E-4 2 4
31 10908574 The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. Pubmed 2.303E-7 3.343E-6 2.236E-5 1.036E-4 2 4
32 12723973 Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
33 12944400 An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
34 16314397 Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
35 18369367 NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
36 22522823 The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
37 17978099 Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
38 11163187 Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Pubmed 3.838E-7 4.545E-6 3.039E-5 1.727E-4 2 5
39 25662211 Luzp4 defines a new mRNA export pathway in cancer cells. Pubmed 4.918E-7 5.675E-6 3.795E-5 2.213E-4 3 80
40 19864460 Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export. Pubmed 5.756E-7 6.167E-6 4.125E-5 2.590E-4 2 6
41 10228171 The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. Pubmed 5.756E-7 6.167E-6 4.125E-5 2.590E-4 2 6
42 12554878 Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. Pubmed 5.756E-7 6.167E-6 4.125E-5 2.590E-4 2 6
43 12417715 Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Pubmed 8.058E-7 7.554E-6 5.052E-5 3.626E-4 2 7
44 19410547 Disassembly of exon junction complexes by PYM. Pubmed 8.058E-7 7.554E-6 5.052E-5 3.626E-4 2 7
45 20123736 TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. Pubmed 8.058E-7 7.554E-6 5.052E-5 3.626E-4 2 7
46 18256688 Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. Pubmed 8.058E-7 7.554E-6 5.052E-5 3.626E-4 2 7
47 22961380 Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Pubmed 8.058E-7 7.554E-6 5.052E-5 3.626E-4 2 7
48 23299939 Chtop is a component of the dynamic TREX mRNA export complex. Pubmed 8.058E-7 7.554E-6 5.052E-5 3.626E-4 2 7
49 15680326 Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Pubmed 1.074E-6 9.866E-6 6.598E-5 4.834E-4 2 8
50 15361857 eIF4G is required for the pioneer round of translation in mammalian cells. Pubmed 1.381E-6 1.219E-5 8.149E-5 6.215E-4 2 9
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 1550 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RBM8A RBM8A interactions 2.028E-12 1.962E-9 1.555E-8 3.144E-9 6 117
2 int:UPF3A UPF3A interactions 2.532E-12 1.962E-9 1.555E-8 3.925E-9 5 40
3 int:UPF3B UPF3B interactions 8.141E-12 4.206E-9 3.333E-8 1.262E-8 5 50
4 int:PYM1 PYM1 interactions 5.753E-11 2.084E-8 1.651E-7 8.917E-8 5 73
5 int:RNPS1 RNPS1 interactions 6.722E-11 2.084E-8 1.651E-7 1.042E-7 6 208
6 int:SRSF2 SRSF2 interactions 1.640E-9 4.236E-7 3.357E-6 2.542E-6 5 141
7 int:MAGOH MAGOH interactions 8.399E-9 1.860E-6 1.474E-5 1.302E-5 5 195
8 int:EIF4A3 EIF4A3 interactions 5.720E-8 1.108E-5 8.782E-5 8.866E-5 5 286
9 int:SRSF7 SRSF7 interactions 3.655E-7 6.295E-5 4.988E-4 5.666E-4 4 153
10 int:SMG1 SMG1 interactions 4.295E-7 6.657E-5 5.275E-4 6.657E-4 3 36
11 int:SRRM1 SRRM1 interactions 5.981E-7 8.205E-5 6.502E-4 9.270E-4 4 173
12 int:SRPK2 SRPK2 interactions 6.353E-7 8.205E-5 6.502E-4 9.846E-4 5 464
13 int:RBM39 RBM39 interactions 7.167E-7 8.545E-5 6.771E-4 1.111E-3 4 181
14 int:PRPF19 PRPF19 interactions 1.068E-6 1.183E-4 9.370E-4 1.656E-3 4 200
15 int:CASC3 CASC3 interactions 1.249E-6 1.290E-4 1.022E-3 1.935E-3 3 51
16 int:DHX15 DHX15 interactions 1.479E-6 1.433E-4 1.135E-3 2.293E-3 4 217
17 int:SRSF4 SRSF4 interactions 2.735E-6 2.422E-4 1.919E-3 4.239E-3 3 66
18 int:UPF1 UPF1 interactions 2.813E-6 2.422E-4 1.919E-3 4.360E-3 4 255
19 int:SNRNP40 SNRNP40 interactions 3.712E-6 2.767E-4 2.192E-3 5.753E-3 3 73
20 int:NXF3 NXF3 interactions 3.748E-6 2.767E-4 2.192E-3 5.810E-3 2 7
21 int:XIST XIST interactions 3.748E-6 2.767E-4 2.192E-3 5.810E-3 2 7
22 int:SRSF6 SRSF6 interactions 4.713E-6 3.321E-4 2.631E-3 7.306E-3 3 79
23 int:EXOSC2 EXOSC2 interactions 6.307E-6 4.216E-4 3.341E-3 9.776E-3 3 87
24 int:RBM25 RBM25 interactions 6.528E-6 4.216E-4 3.341E-3 1.012E-2 3 88
25 int:NKAPD1 NKAPD1 interactions 6.986E-6 4.306E-4 3.412E-3 1.083E-2 3 90
26 int:LUZP4 LUZP4 interactions 7.222E-6 4.306E-4 3.412E-3 1.119E-2 3 91
27 int:UPF2 UPF2 interactions 8.485E-6 4.871E-4 3.860E-3 1.315E-2 3 96
28 int:HNRNPM HNRNPM interactions 1.044E-5 5.781E-4 4.581E-3 1.619E-2 4 355
29 int:EPB41L3 EPB41L3 interactions 1.460E-5 7.806E-4 6.185E-3 2.264E-2 3 115
30 int:NXT1 NXT1 interactions 1.622E-5 8.379E-4 6.639E-3 2.514E-2 2 14
31 int:BMI1 BMI1 interactions 1.808E-5 9.042E-4 7.165E-3 2.803E-2 4 408
32 int:SAP18 SAP18 interactions 1.875E-5 9.084E-4 7.198E-3 2.907E-2 3 125
33 int:PNN PNN interactions 2.109E-5 9.745E-4 7.721E-3 3.270E-2 3 130
34 int:AGPAT1 AGPAT1 interactions 2.138E-5 9.745E-4 7.721E-3 3.313E-2 2 16
35 int:ACIN1 ACIN1 interactions 2.259E-5 1.000E-3 7.925E-3 3.501E-2 3 133
36 int:ZC3H18 ZC3H18 interactions 2.748E-5 1.183E-3 9.373E-3 4.259E-2 3 142
37 int:TADA2A TADA2A interactions 3.237E-5 1.356E-3 1.074E-2
5.017E-2
 3 150
38 int:ALYREF ALYREF interactions 3.639E-5 1.474E-3 1.168E-2
5.640E-2
 3 156
39 int:SRSF3 SRSF3 interactions 3.709E-5 1.474E-3 1.168E-2
5.749E-2
 3 157
40 int:RBMX RBMX interactions 3.998E-5 1.512E-3 1.198E-2
6.198E-2
 3 161
41 int:THRAP3 THRAP3 interactions 3.998E-5 1.512E-3 1.198E-2
6.198E-2
 3 161
42 int:SMG6 SMG6 interactions 4.109E-5 1.517E-3 1.202E-2
6.369E-2
 2 22
43 int:RAN RAN interactions 4.460E-5 1.608E-3 1.274E-2
6.912E-2
 3 167
44 int:RIOX2 RIOX2 interactions 5.776E-5 2.035E-3 1.612E-2
8.953E-2
 2 26
45 int:HNRNPC HNRNPC interactions 6.969E-5 2.369E-3 1.877E-2
1.080E-1
 3 194
46 int:SRSF1 SRSF1 interactions 7.076E-5 2.369E-3 1.877E-2
1.097E-1
 3 195
47 int:SNRNP200 SNRNP200 interactions 7.185E-5 2.369E-3 1.877E-2
1.114E-1
 3 196
48 int:TRA2B TRA2B interactions 8.330E-5 2.673E-3 2.118E-2
1.291E-1
 3 206
49 int:PUF60 PUF60 interactions 8.450E-5 2.673E-3 2.118E-2
1.310E-1
 3 207
50 int:PPIE PPIE interactions 9.328E-5 2.892E-3 2.291E-2
1.446E-1
 3 214
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20p12-p11.2 20p12-p11.2 4.616E-4 2.461E-3 6.689E-3 3.693E-3 1 2
2 10p14-p13 10p14-p13 9.229E-4 2.461E-3 6.689E-3 7.384E-3 1 4
3 Xq25-q26 Xq25-q26 9.229E-4 2.461E-3 6.689E-3 7.384E-3 1 4
4 11q12-q13 11q12-q13 1.384E-3 2.768E-3 7.524E-3 1.107E-2 1 6
5 6p22.3 6p22.3 1.057E-2 1.691E-2 4.596E-2
8.455E-2
 1 46
6 1p32.3 1p32.3 1.399E-2 1.782E-2 4.842E-2
1.120E-1
 1 61
7 1p36.11 1p36.11 1.559E-2 1.782E-2 4.842E-2
1.247E-1
 1 68
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 49 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1236 RNA binding motif containing|ASAP complex genenames.org 4.946E-4 1.319E-3 2.748E-3 1.978E-3 1 3
2 1238 Exon junction complex genenames.org 6.594E-4 1.319E-3 2.748E-3 2.638E-3 1 4
3 103 X-linked mental retardation|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 1.444E-2 1.925E-2 4.011E-2
5.776E-2
 1 88
4 725 RNA binding motif containing genenames.org 3.471E-2 3.471E-2
7.232E-2
1.389E-1
 1 213

13: Coexpression [Display Chart] 8 input genes in category / 715 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18535662-TableS1b Mouse Lymphoma Wu08 1114genes GeneSigDB 1.353E-5 4.935E-3 3.529E-2 9.676E-3 4 495
2 M1913 Genes down-regulated in neural stem cells (NSC) at 36 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.735E-5 4.935E-3 3.529E-2 1.955E-2 3 185
3 M4050 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 4.935E-3 3.529E-2 2.468E-2 3 200
4 M6619 Genes down-regulated in bone marrow-derived macrophages with IL6 [GeneID=3569] knockout and 45 min of stimulation by: LPS versus IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 4.935E-3 3.529E-2 2.468E-2 3 200
5 M8597 Genes up-regulated in dendritic cells versus macrophages sorted as ITGAX int [GeneID=3687] and EMR1 high [GeneID=2015]. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 4.935E-3 3.529E-2 2.468E-2 3 200
6 M29 Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.196E-4 3.808E-2
2.723E-1
2.285E-1
 3 424
7 18535662-TableS2b Mouse Lymphoma Wu08 1016genes GeneSigDB 4.059E-4 3.995E-2
2.857E-1
2.902E-1
 3 460
8 14767473-Table3 Human Pancreas Nakamura04 168genes GeneSigDB 1.155E-3 3.995E-2
2.857E-1
8.255E-1
 2 151
9 M17225 Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not up-regulated at the previous time point, 12 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.232E-3 3.995E-2
2.857E-1
8.805E-1
 2 156
10 M368 Genes up-regulated in macrophages differentiated for 5 days in the presence of: IL4 [GeneID=3565] versus IL4 [GeneID=3565] and dexamethasone [PubChem=5743]. MSigDB C7: Immunologic Signatures (v6.0) 1.443E-3 3.995E-2
2.857E-1
1.000E0
 2 169
11 M6564 Genes up-regulated in lesional skin biopsies from mycosis fundoides patients compared to the normal skin samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.581E-3 3.995E-2
2.857E-1
1.000E0
 2 177
12 M2641 Genes up-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 24h. MSigDB C6: Oncogenic Signatures (v6.0) 1.688E-3 3.995E-2
2.857E-1
1.000E0
 2 183
13 M2674 Genes up-regulated in HUVEC cells (endothelium) by treatment with PIGF [Gene ID=5281]. MSigDB C6: Oncogenic Signatures (v6.0) 1.837E-3 3.995E-2
2.857E-1
1.000E0
 2 191
14 M6114 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (48h) versus IL4 [GeneID=3565] (48h). MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.995E-2
2.857E-1
1.000E0
 2 198
15 M5335 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 12 h versus PMN treated with F. tularensis vaccine at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.995E-2
2.857E-1
1.000E0
 2 199
16 M3355 Genes down-regulated in comparison of dendritic cells (DC) at 4 h after LPS (TLR4 agonist) stimulation versus those at 16 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
17 M8559 Genes up-regulated in effector CD8 T cells: CXCR1+ [GeneID=3577] versus CXCR1- [GeneID=3577]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
18 M9477 Genes down-regulated in CD8 T effector cells at day 6 of chronic infection: LCMV-Armstrong versus LCMV-Clone 13. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
19 M5274 Genes down-regulated in comparison of type 2 myeloid (T2M) cells treated with IL25 [GeneID=64806] versus macrophages treated with IL25 [GeneID=64806]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
20 M9055 Genes down-regulated in Ly6C monocytes: high versus low. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
21 M5781 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from patients with type 2 diabetes at the time of diagnosis. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
22 M8528 Genes up-regulated in macrophages: alternatively activated M2 versus MYC [GeneID=4609] inhibited. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
23 M8524 Genes down-regulated in macrophages: resting differentiated versus alternatively activated M2. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
24 M4249 Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h versus those at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
25 M8506 Genes down-regulated in CD8 T cells: over-expressing ID3 [GeneID=3399] versus ID3 [GeneID=3399] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
26 M4830 Genes up-regulated in comparison of CD4 [GeneID=920] T cells versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
27 M8278 Genes down-regulated in B lymphocytes stimulated by anti-IgM for 8h: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
28 M5070 Genes down-regulated in comparison of CD4+ [GeneID=920] CD8- thymocytes versus CD4- [GeneID=920] CD8+ thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
29 M6653 Genes up-regulated in bone marrow-derived macrophages at 45 min of stimulation by LPS: IL6 [GeneID=3469] knockout versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
30 M7606 Genes up-regulated in CD11b Tumor from BALBc mouse versus CD11b Tumor from C57BL6 mouse. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
31 M5128 Genes down-regulated in comparison of CD8 dendritic cells (DC) versus CD4- [GeneID=920] CD8- DCs. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
32 M5285 Genes up-regulated in comparison of macrophages treated with IL25 [GeneID=64806] versus neutrophils treated with IL25 [GeneID=64806]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
33 M7965 Genes down-regulated in wildtype bone marrow-derived macrophages treated with IL4 [GeneID=3565]: control versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
34 M5159 Genes down-regulated in comparison of macrophages versus macrophages exposed to L.donovani. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
35 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
36 M3363 Genes down-regulated in comparison of Th2 cells versus Th17 cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.995E-2
2.857E-1
1.000E0
 2 200
37 M1444 Genes down-regulated in esophagus by the carcinogen NMBA [PubChem=13643] and brought back to normal by a diet with PEITC [PubChem=16741] or black raspberries. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.418E-3 4.673E-2
3.341E-1
1.000E0
 1 7
Show 32 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 331 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour Wilms Mast cell/Kidney Tumour Wilms IN15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour Wilms Mast cell/Kidney Tumour Wilms IN15 Adult, Development, and Cancer types 3.688E-5 1.221E-2
7.790E-2
 1.221E-2 3 193
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour VHL RCC U U/Kidney Tumour VHL RCC U15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour VHL RCC U U/Kidney Tumour VHL RCC U15 Adult, Development, and Cancer types 1.666E-4 2.388E-2
1.524E-1
5.514E-2
 2 54
3 10X Human 68K PBMC CD4+/CD45RA+/CD25- Naive T Subtype CD4+/CD45RA+/CD25- Naive T-CD4+/CD45RA+/CD25- Naive T c6 Top 200 Genes 10X Human 68K PBMC CD4+/CD45RA+/CD25- Naive T Subtype CD4+/CD45RA+/CD25- Naive T-CD4+/CD45RA+/CD25- Naive T c6 Top 200 Genes 2.898E-4 2.388E-2
1.524E-1
9.593E-2
 3 387
4 10X Human 8K PBMC Immune Subtype Immune-STMN1 TK1 KIAA0101 Top 200 Genes 10X Human 8K PBMC Immune Subtype Immune-STMN1 TK1 KIAA0101 Top 200 Genes 3.010E-4 2.388E-2
1.524E-1
9.962E-2
 3 392
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF21 Adult, Development, and Cancer types 4.945E-4 2.388E-2
1.524E-1
1.637E-1
 2 93
6 6mo cortical organoids wt 6mo cortical organoids wt Subtype 5 static Subtype 5 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype 5 static Subtype 5 Top 100 Genes 4.945E-4 2.388E-2
1.524E-1
1.637E-1
 2 93
7 6mo cortical organoids wt 6mo cortical organoids wt Subtype 6 static Subtype 6 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype 6 static Subtype 6 Top 100 Genes 5.051E-4 2.388E-2
1.524E-1
1.672E-1
 2 94
Show 2 more annotations

15: Computational [Display Chart] 7 input genes in category / 83 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7309 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.423E-5 3.671E-3 1.836E-2 3.671E-3 4 345
2 M3665 MORF CDC10 Neighborhood of CDC10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.505E-5 3.945E-3 1.973E-2 7.890E-3 3 143
3 M14651 GNF2 TDG Neighborhood of TDG MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.454E-4 4.930E-3 2.466E-2 2.037E-2 2 35
4 M15222 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.766E-4 4.930E-3 2.466E-2 2.296E-2 3 205
5 M2705 MORF ACP1 Neighborhood of ACP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.970E-4 4.930E-3 2.466E-2 2.465E-2 3 210
6 M18997 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.085E-4 5.251E-3 2.627E-2 3.391E-2 3 234
7 M18698 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.620E-4 5.251E-3 2.627E-2 3.835E-2 3 244
8 M11080 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.199E-4 5.251E-3 2.627E-2 4.315E-2 3 254
9 M7191 MORF DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.694E-4 5.251E-3 2.627E-2 4.726E-2 3 262
10 M11406 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.702E-4 5.562E-3 2.782E-2
5.563E-2
 3 277
11 M10882 MORF SNRP70 Neighborhood of SNRP70 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.482E-4 5.562E-3 2.782E-2
6.210E-2
 2 61
12 M1209 MORF TERF1 Neighborhood of TERF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.493E-4 5.562E-3 2.782E-2
7.049E-2
 2 65
13 M18398 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.711E-4 5.562E-3 2.782E-2
7.231E-2
 3 303
14 M11176 MORF CDK2 Neighborhood of CDK2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.013E-3 6.003E-3 3.003E-2
8.405E-2
 2 71
15 M12733 MORF CCNI Neighborhood of CCNI MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.551E-3 8.583E-3 4.293E-2
1.287E-1
 2 88
16 M1109 MORF UBE2N Neighborhood of UBE2N MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.768E-3 9.169E-3 4.586E-2
1.467E-1
 2 94
17 M1232 MORF RAF1 Neighborhood of RAF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.411E-3 1.112E-2
5.562E-2
2.001E-1
 2 110
18 M5178 GNF2 HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.411E-3 1.112E-2
5.562E-2
2.001E-1
 2 110
19 M16184 MORF ERH Neighborhood of ERH MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.587E-3 1.130E-2
5.654E-2
2.147E-1
 2 114
20 M3928 GNF2 DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.816E-3 1.168E-2
5.845E-2
2.337E-1
 2 119
21 M16886 MORF PPP2CA Neighborhood of PPP2CA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.200E-3 1.265E-2
6.327E-2
2.656E-1
 2 127
22 M334 MORF EIF4A2 Neighborhood of EIF4A2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.714E-3 1.379E-2
6.897E-2
3.082E-1
 2 137
23 M6545 MORF FBL Neighborhood of FBL MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.821E-3 1.379E-2
6.897E-2
3.171E-1
 2 139
24 M13545 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.435E-3 1.534E-2
7.673E-2
3.681E-1
 2 150
25 M12947 MORF CTBP1 Neighborhood of CTBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.534E-3 1.822E-2
9.112E-2
4.593E-1
 2 168
26 M19767 MORF G22P1 Neighborhood of G22P1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.729E-3 1.822E-2
9.112E-2
4.755E-1
 2 171
27 M446 MORF HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.926E-3 1.822E-2
9.112E-2
4.919E-1
 2 174
28 M19884 MORF ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.543E-3 2.236E-2
1.118E-1
6.261E-1
 2 197
29 M10939 MORF UBE2I Neighborhood of UBE2I MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.087E-2 3.111E-2
1.556E-1
9.021E-1
 2 238
30 M17615 MORF RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.365E-2 3.772E-2
1.887E-1
1.000E0
 2 268
31 M13419 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.444E-2 3.772E-2
1.887E-1
1.000E0
 2 276
32 M7895 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.454E-2 3.772E-2
1.887E-1
1.000E0
 2 277
33 M6308 GNF2 RPA1 Neighborhood of RPA1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.937E-2 4.872E-2
2.437E-1
1.000E0
 1 28
Show 28 more annotations

16: MicroRNA [Display Chart] 8 input genes in category / 291 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-652:mirSVR highEffct hsa-miR-652:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.277E-5 1.245E-2
7.781E-2
 1.245E-2 2 90
2 hsa-miR-874:PITA hsa-miR-874:PITA TOP PITA 1.174E-4 1.708E-2
1.068E-1
 3.415E-2 2 149
3 hsa-miR-576-3p:PITA hsa-miR-576-3p:PITA TOP PITA 2.417E-4 2.345E-2
1.466E-1
7.034E-2
 2 214
4 hsa-miR-149-5p:TargetScan hsa-miR-149-5p TargetScan 6.835E-4 3.835E-2
2.398E-1
1.989E-1
 2 361
5 hsa-miR-587:PITA hsa-miR-587:PITA TOP PITA 9.010E-4 3.835E-2
2.398E-1
2.622E-1
 2 415
6 hsa-miR-874:mirSVR highEffct hsa-miR-874:mirSVR conserved highEffect-0.5 MicroRNA.org 9.096E-4 3.835E-2
2.398E-1
2.647E-1
 2 417
7 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 9.226E-4 3.835E-2
2.398E-1
2.685E-1
 2 420
8 hsa-miR-125a-5p:mirSVR highEffct hsa-miR-125a-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 1.157E-3 3.865E-2
2.416E-1
3.368E-1
 2 471
9 hsa-miR-219-5p:mirSVR highEffct hsa-miR-219-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 1.196E-3 3.865E-2
2.416E-1
3.482E-1
 2 479
10 hsa-miR-652-3p:TargetScan hsa-miR-652-3p TargetScan 1.328E-3 3.865E-2
2.416E-1
3.865E-1
 1 12
11 hsa-miR-487b-3p:Functional MTI Functional MTI miRTarbase 2.213E-3 4.213E-2
2.634E-1
6.439E-1
 1 20
12 hsa-miR-151-5p:PITA hsa-miR-151-5p:PITA TOP PITA 3.318E-3 4.213E-2
2.634E-1
9.654E-1
 1 30
13 hsa-miR-6881-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.538E-3 4.213E-2
2.634E-1
1.000E0
 1 32
14 hsa-miR-99b-5p:TargetScan hsa-miR-99b-5p TargetScan 4.752E-3 4.213E-2
2.634E-1
1.000E0
 1 43
15 hsa-miR-99a-5p:TargetScan hsa-miR-99a-5p TargetScan 4.752E-3 4.213E-2
2.634E-1
1.000E0
 1 43
16 hsa-miR-100-5p:TargetScan hsa-miR-100-5p TargetScan 4.752E-3 4.213E-2
2.634E-1
1.000E0
 1 43
17 hsa-miR-133a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.752E-3 4.213E-2
2.634E-1
1.000E0
 1 43
18 hsa-miR-4774-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.083E-3 4.213E-2
2.634E-1
1.000E0
 1 46
19 hsa-miR-4299:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.193E-3 4.213E-2
2.634E-1
1.000E0
 1 47
20 hsa-miR-4693-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 4.213E-2
2.634E-1
1.000E0
 1 49
21 hsa-miR-7153-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.524E-3 4.213E-2
2.634E-1
1.000E0
 1 50
22 hsa-miR-7161-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.634E-3 4.213E-2
2.634E-1
1.000E0
 1 51
23 hsa-miR-1278:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.634E-3 4.213E-2
2.634E-1
1.000E0
 1 51
24 hsa-miR-3617-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.744E-3 4.213E-2
2.634E-1
1.000E0
 1 52
25 hsa-miR-592:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.075E-3 4.213E-2
2.634E-1
1.000E0
 1 55
26 hsa-miR-584-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 4.213E-2
2.634E-1
1.000E0
 1 56
27 hsa-miR-718:mirSVR highEffct hsa-miR-718:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.295E-3 4.213E-2
2.634E-1
1.000E0
 1 57
28 hsa-miR-3074-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.515E-3 4.213E-2
2.634E-1
1.000E0
 1 59
29 hsa-miR-138-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.736E-3 4.213E-2
2.634E-1
1.000E0
 1 61
30 hsa-miR-499b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 4.213E-2
2.634E-1
1.000E0
 1 63
31 hsa-miR-6853-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 4.213E-2
2.634E-1
1.000E0
 1 63
32 AAGTCCA,MIR-422A:MSigDB AAGTCCA,MIR-422A:MSigDB MSigDB 7.066E-3 4.213E-2
2.634E-1
1.000E0
 1 64
33 AAGTCCA,MIR-422B:MSigDB AAGTCCA,MIR-422B:MSigDB MSigDB 7.066E-3 4.213E-2
2.634E-1
1.000E0
 1 64
34 hsa-miR-4277:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.066E-3 4.213E-2
2.634E-1
1.000E0
 1 64
35 hsa-miR-888-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.066E-3 4.213E-2
2.634E-1
1.000E0
 1 64
36 hsa-miR-4712-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.286E-3 4.213E-2
2.634E-1
1.000E0
 1 66
37 hsa-miR-499a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.396E-3 4.213E-2
2.634E-1
1.000E0
 1 67
38 hsa-miR-5100:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.946E-3 4.213E-2
2.634E-1
1.000E0
 1 72
39 hsa-miR-1225-3p:PITA hsa-miR-1225-3p:PITA TOP PITA 7.946E-3 4.213E-2
2.634E-1
1.000E0
 1 72
40 hsa-miR-888-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.496E-3 4.213E-2
2.634E-1
1.000E0
 1 77
41 hsa-miR-7156-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.716E-3 4.213E-2
2.634E-1
1.000E0
 1 79
42 hsa-miR-4273:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.825E-3 4.213E-2
2.634E-1
1.000E0
 1 80
43 hsa-miR-8076:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.825E-3 4.213E-2
2.634E-1
1.000E0
 1 80
44 hsa-miR-633:Functional MTI Functional MTI miRTarbase 8.935E-3 4.213E-2
2.634E-1
1.000E0
 1 81
45 hsa-miR-6739-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.045E-3 4.213E-2
2.634E-1
1.000E0
 1 82
46 hsa-miR-493:PITA hsa-miR-493:PITA TOP PITA 9.045E-3 4.213E-2
2.634E-1
1.000E0
 1 82
47 hsa-miR-5195-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.155E-3 4.213E-2
2.634E-1
1.000E0
 1 83
48 hsa-miR-769-5p:PITA hsa-miR-769-5p:PITA TOP PITA 9.155E-3 4.213E-2
2.634E-1
1.000E0
 1 83
49 hsa-miR-187-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.265E-3 4.213E-2
2.634E-1
1.000E0
 1 84
50 hsa-miR-1183:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.375E-3 4.213E-2
2.634E-1
1.000E0
 1 85
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 310 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000446186 1i32 Stitch 8.006E-13 2.482E-10 1.567E-9 2.482E-10 6 129
2 CID000125643 UDP-FGlc Stitch 6.954E-12 1.078E-9 6.807E-9 2.156E-9 5 62
3 CID000000617 DL-Serine Stitch 4.124E-7 4.261E-5 2.691E-4 1.278E-4 4 203
4 CID000465394 N-(aminomethyl)succinamic acid Stitch 8.317E-5 6.446E-3 4.071E-2 2.578E-2 2 40
5 CID003070537 RG-2 Stitch 2.009E-4 1.245E-2
7.865E-2
6.227E-2
 2 62
6 CID000098207 Phe-gly Stitch 2.786E-4 1.337E-2
8.446E-2
8.637E-2
 2 73
7 CID000643956 7-chloro-DL-tryptophan Stitch 3.020E-4 1.337E-2
8.446E-2
9.362E-2
 2 76
8 CID000008420 2-naphthalenesulfonate Stitch 4.423E-4 1.557E-2
9.831E-2
1.371E-1
 2 92
9 CID000073271 uracil-4-acetic acid Stitch 4.520E-4 1.557E-2
9.831E-2
1.401E-1
 2 93
10 CID000141030 MoF4 Stitch 1.050E-3 3.256E-2
2.056E-1
3.256E-1
 1 3
11 CID004604180 AC1NDNTH Stitch 1.695E-3 3.689E-2
2.330E-1
5.253E-1
 2 181
12 1765 UP Ellipticine [519-23-3]; Up 200; 16.2uM; HL60; HG-U133A Broad Institute CMAP Up 1.750E-3 3.689E-2
2.330E-1
5.426E-1
 2 184
13 CID006420160 2f34 Stitch 1.826E-3 3.689E-2
2.330E-1
5.662E-1
 2 188
14 7074 DN MS-275; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.846E-3 3.689E-2
2.330E-1
5.721E-1
 2 189
15 1409 DN Etofylline [519-37-9]; Down 200; 17.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.943E-3 3.689E-2
2.330E-1
6.023E-1
 2 194
16 1431 DN Oxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.963E-3 3.689E-2
2.330E-1
6.085E-1
 2 195
17 1443 DN Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP Down 2.023E-3 3.689E-2
2.330E-1
6.271E-1
 2 198
18 CID000015325 DNTB Stitch 2.401E-3 4.134E-2
2.611E-1
7.442E-1
 2 216
19 CID000200884 P-15 Stitch 2.534E-3 4.134E-2
2.611E-1
7.854E-1
 2 222
20 CID005288137 AC1NRAX5 Stitch 3.148E-3 4.880E-2
3.082E-1
9.760E-1
 1 9
Show 15 more annotations

18: Disease [Display Chart] 8 input genes in category / 116 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C1970822 X-linked mental retardation, syndromic 14 Clinical Variations 4.937E-4 1.909E-2
1.018E-1
5.727E-2
 1 1
2 C1970822 Mental Retardation, X-Linked, Syndromic 14 DisGeNET Curated 4.937E-4 1.909E-2
1.018E-1
5.727E-2
 1 1
3 OMIN:300676 MENTAL RETARDATION, X-LINKED, SYNDROMIC 14; MRXS14 OMIM 4.937E-4 1.909E-2
1.018E-1
5.727E-2
 1 1
4 C3714757 Juvenile rheumatoid arthritis DisGeNET Curated 1.654E-3 3.815E-2
2.035E-1
1.919E-1
 2 127
5 C0796022 Lujan Fryns syndrome DisGeNET Curated 1.973E-3 3.815E-2
2.035E-1
2.289E-1
 1 4
6 C0015269 Exhibitionism DisGeNET BeFree 1.973E-3 3.815E-2
2.035E-1
2.289E-1
 1 4
7 C0036346 Schizophrenia, Childhood DisGeNET Curated 2.466E-3 4.087E-2
2.180E-1
2.861E-1
 1 5
Show 2 more annotations