Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc54_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 46 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008083 growth factor activity 7.376E-10 3.393E-8 1.498E-7 3.393E-8 6 166
2 GO:0005088 Ras guanyl-nucleotide exchange factor activity 5.523E-9 1.270E-7 5.610E-7 2.541E-7 6 232
3 GO:0005085 guanyl-nucleotide exchange factor activity 2.884E-8 4.422E-7 1.953E-6 1.327E-6 6 306
4 GO:0030116 glial cell-derived neurotrophic factor receptor binding 4.480E-7 5.152E-6 2.275E-5 2.061E-5 2 2
5 GO:0005126 cytokine receptor binding 1.000E-6 9.205E-6 4.065E-5 4.602E-5 5 289
6 GO:0005166 neurotrophin p75 receptor binding 2.686E-6 2.059E-5 9.095E-5 1.236E-4 2 4
7 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1.233E-5 8.103E-5 3.579E-4 5.672E-4 3 67
8 GO:0019199 transmembrane receptor protein kinase activity 3.097E-5 1.781E-4 7.865E-4 1.425E-3 3 91
9 GO:0005165 neurotrophin receptor binding 4.058E-5 2.074E-4 9.160E-4 1.867E-3 2 14
10 GO:0070851 growth factor receptor binding 1.191E-4 5.480E-4 2.420E-3 5.480E-3 3 143
11 GO:0004713 protein tyrosine kinase activity 2.429E-4 1.016E-3 4.486E-3 1.117E-2 3 182
12 GO:0005147 oncostatin-M receptor binding 1.393E-3 5.339E-3 2.358E-2
6.407E-2
 1 2
13 GO:0016167 glial cell-derived neurotrophic factor receptor activity 2.089E-3 7.390E-3 3.264E-2
9.607E-2
 1 3
14 GO:0038085 vascular endothelial growth factor binding 3.479E-3 1.067E-2 4.712E-2
1.600E-1
 1 5
15 GO:0005127 ciliary neurotrophic factor receptor binding 3.479E-3 1.067E-2 4.712E-2
1.600E-1
 1 5
16 GO:0019838 growth factor binding 4.245E-3 1.178E-2
5.204E-2
1.953E-1
 2 142
17 GO:0048406 nerve growth factor binding 4.867E-3 1.178E-2
5.204E-2
2.239E-1
 1 7
18 GO:0005021 vascular endothelial growth factor-activated receptor activity 4.867E-3 1.178E-2
5.204E-2
2.239E-1
 1 7
19 GO:0005138 interleukin-6 receptor binding 4.867E-3 1.178E-2
5.204E-2
2.239E-1
 1 7
20 GO:0004985 opioid receptor activity 5.561E-3 1.218E-2
5.380E-2
2.558E-1
 1 8
21 GO:0008046 axon guidance receptor activity 5.561E-3 1.218E-2
5.380E-2
2.558E-1
 1 8
22 GO:0043121 neurotrophin binding 7.638E-3 1.597E-2
7.054E-2
3.514E-1
 1 11
23 GO:0032036 myosin heavy chain binding 9.712E-3 1.932E-2
8.533E-2
4.468E-1
 1 14
24 GO:0005125 cytokine activity 1.008E-2 1.932E-2
8.533E-2
4.637E-1
 2 222
25 GO:0042056 chemoattractant activity 2.002E-2 3.684E-2
1.627E-1
9.210E-1
 1 29
26 GO:0001786 phosphatidylserine binding 2.275E-2 4.026E-2
1.778E-1
1.000E0
 1 33
27 GO:0051879 Hsp90 protein binding 2.480E-2 4.225E-2
1.866E-1
1.000E0
 1 36
28 GO:0043548 phosphatidylinositol 3-kinase binding 2.616E-2 4.298E-2
1.898E-1
1.000E0
 1 38
29 GO:0015026 coreceptor activity 2.888E-2 4.580E-2
2.023E-1
1.000E0
 1 42
Show 24 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 701 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043523 regulation of neuron apoptotic process 7.724E-11 5.415E-8 3.861E-7 5.415E-8 7 236
2 GO:0051402 neuron apoptotic process 1.565E-10 5.487E-8 3.912E-7 1.097E-7 7 261
3 GO:1901214 regulation of neuron death 4.872E-10 1.008E-7 7.191E-7 3.415E-7 7 307
4 GO:0043524 negative regulation of neuron apoptotic process 5.755E-10 1.008E-7 7.191E-7 4.034E-7 6 159
5 GO:0070997 neuron death 1.122E-9 1.572E-7 1.121E-6 7.862E-7 7 346
6 GO:0007422 peripheral nervous system development 1.614E-9 1.886E-7 1.345E-6 1.132E-6 5 80
7 GO:1901215 negative regulation of neuron death 2.584E-9 2.588E-7 1.845E-6 1.811E-6 6 204
8 GO:0048483 autonomic nervous system development 2.093E-8 1.834E-6 1.308E-5 1.467E-5 4 45
9 GO:0048484 enteric nervous system development 7.569E-8 5.896E-6 4.204E-5 5.306E-5 3 13
10 GO:0018108 peptidyl-tyrosine phosphorylation 1.140E-7 7.490E-6 5.341E-5 7.991E-5 6 385
11 GO:0018212 peptidyl-tyrosine modification 1.175E-7 7.490E-6 5.341E-5 8.239E-5 6 387
12 GO:0033138 positive regulation of peptidyl-serine phosphorylation 4.386E-7 2.562E-5 1.827E-4 3.075E-4 4 95
13 GO:0050927 positive regulation of positive chemotaxis 8.618E-7 4.647E-5 3.314E-4 6.041E-4 3 28
14 GO:0050926 regulation of positive chemotaxis 9.609E-7 4.811E-5 3.431E-4 6.736E-4 3 29
15 GO:0097021 lymphocyte migration into lymphoid organs 1.349E-6 5.799E-5 4.135E-4 9.456E-4 2 3
16 GO:0061146 Peyer's patch morphogenesis 1.349E-6 5.799E-5 4.135E-4 9.456E-4 2 3
17 GO:0033135 regulation of peptidyl-serine phosphorylation 1.406E-6 5.799E-5 4.135E-4 9.858E-4 4 127
18 GO:0032103 positive regulation of response to external stimulus 1.884E-6 7.337E-5 5.232E-4 1.321E-3 5 328
19 GO:0046425 regulation of JAK-STAT cascade 3.532E-6 1.238E-4 8.828E-4 2.476E-3 4 160
20 GO:1904892 regulation of STAT cascade 3.532E-6 1.238E-4 8.828E-4 2.476E-3 4 160
21 GO:0007259 JAK-STAT cascade 6.840E-6 2.180E-4 1.554E-3 4.795E-3 4 189
22 GO:0097696 STAT cascade 6.840E-6 2.180E-4 1.554E-3 4.795E-3 4 189
23 GO:0050918 positive chemotaxis 8.446E-6 2.574E-4 1.835E-3 5.920E-3 3 59
24 GO:0021675 nerve development 1.814E-5 5.298E-4 3.778E-3 1.272E-2 3 76
25 GO:0018105 peptidyl-serine phosphorylation 2.552E-5 7.156E-4 5.103E-3 1.789E-2 4 264
26 GO:0018209 peptidyl-serine modification 3.125E-5 8.425E-4 6.007E-3 2.190E-2 4 278
27 GO:0048537 mucosal-associated lymphoid tissue development 3.494E-5 8.746E-4 6.236E-3 2.449E-2 2 13
28 GO:0048541 Peyer's patch development 3.494E-5 8.746E-4 6.236E-3 2.449E-2 2 13
29 GO:0072216 positive regulation of metanephros development 4.074E-5 9.848E-4 7.022E-3 2.856E-2 2 14
30 GO:0050930 induction of positive chemotaxis 5.368E-5 1.254E-3 8.944E-3 3.763E-2 2 16
31 GO:0050921 positive regulation of chemotaxis 9.032E-5 2.042E-3 1.456E-2
6.331E-2
 3 130
32 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein 9.376E-5 2.054E-3 1.465E-2
6.573E-2
 2 21
33 GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein 1.031E-4 2.190E-3 1.562E-2
7.227E-2
 2 22
34 GO:0048485 sympathetic nervous system development 1.129E-4 2.327E-3 1.659E-2
7.912E-2
 2 23
35 GO:0072215 regulation of metanephros development 1.231E-4 2.465E-3 1.758E-2
8.628E-2
 2 24
36 GO:0060384 innervation 1.337E-4 2.604E-3 1.857E-2
9.375E-2
 2 25
37 GO:0042501 serine phosphorylation of STAT protein 1.563E-4 2.962E-3 2.112E-2
1.096E-1
 2 27
38 GO:0048469 cell maturation 2.213E-4 4.019E-3 2.866E-2
1.552E-1
 3 176
39 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2.251E-4 4.019E-3 2.866E-2
1.578E-1
 3 177
40 GO:0050769 positive regulation of neurogenesis 2.293E-4 4.019E-3 2.866E-2
1.608E-1
 4 465
41 GO:0007409 axonogenesis 2.488E-4 4.220E-3 3.009E-2
1.744E-1
 4 475
42 GO:0040017 positive regulation of locomotion 2.528E-4 4.220E-3 3.009E-2
1.772E-1
 4 477
43 GO:0050920 regulation of chemotaxis 3.176E-4 5.178E-3 3.692E-2
2.227E-1
 3 199
44 GO:0048265 response to pain 3.285E-4 5.234E-3 3.732E-2
2.303E-1
 2 39
45 GO:0072210 metanephric nephron development 3.632E-4 5.658E-3 4.035E-2
2.546E-1
 2 41
46 GO:0090184 positive regulation of kidney development 4.186E-4 6.378E-3 4.548E-2
2.934E-1
 2 44
47 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 5.495E-4 7.887E-3
5.624E-2
3.852E-1
 3 240
48 GO:0007411 axon guidance 5.495E-4 7.887E-3
5.624E-2
3.852E-1
 3 240
49 GO:0097485 neuron projection guidance 5.562E-4 7.887E-3
5.624E-2
3.899E-1
 3 241
50 GO:0001709 cell fate determination 5.626E-4 7.887E-3
5.624E-2
3.944E-1
 2 51
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 36 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044228 host cell surface 6.820E-4 2.455E-2
1.025E-1
 2.455E-2 1 1
2 GO:0097058 CRLF-CLCF1 complex 2.045E-3 3.271E-2
1.365E-1
7.361E-2
 1 3
3 GO:0097443 sorting endosome 2.726E-3 3.271E-2
1.365E-1
9.812E-2
 1 4
4 GO:0031225 anchored component of membrane 5.140E-3 4.626E-2
1.931E-1
1.850E-1
 2 160
5 GO:0033643 host cell part 9.509E-3 4.678E-2
1.953E-1
3.423E-1
 1 14
6 GO:0018995 host 1.289E-2 4.678E-2
1.953E-1
4.639E-1
 1 19
7 GO:0043657 host cell 1.289E-2 4.678E-2
1.953E-1
4.639E-1
 1 19
8 GO:0019898 extrinsic component of membrane 1.487E-2 4.678E-2
1.953E-1
5.353E-1
 2 278
9 GO:0044216 other organism cell 1.625E-2 4.678E-2
1.953E-1
5.850E-1
 1 24
10 GO:0044215 other organism 1.625E-2 4.678E-2
1.953E-1
5.850E-1
 1 24
11 GO:0044217 other organism part 1.625E-2 4.678E-2
1.953E-1
5.850E-1
 1 24
12 GO:0005640 nuclear outer membrane 1.692E-2 4.678E-2
1.953E-1
6.092E-1
 1 25
13 GO:0009897 external side of plasma membrane 1.827E-2 4.678E-2
1.953E-1
6.577E-1
 2 310
14 GO:0005769 early endosome 1.872E-2 4.678E-2
1.953E-1
6.738E-1
 2 314
15 GO:0043235 receptor complex 2.161E-2 4.678E-2
1.953E-1
7.781E-1
 2 339
16 GO:0098857 membrane microdomain 2.209E-2 4.678E-2
1.953E-1
7.953E-1
 2 343
17 GO:0045121 membrane raft 2.209E-2 4.678E-2
1.953E-1
7.953E-1
 2 343
Show 12 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 526 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003345 Elevated urinary norepinephrine 2.522E-5 1.357E-3 9.287E-3 1.326E-2 2 8
2 HP:0011665 Takotsubo cardiomyopathy 2.522E-5 1.357E-3 9.287E-3 1.326E-2 2 8
3 HP:0000875 Episodic hypertension 2.522E-5 1.357E-3 9.287E-3 1.326E-2 2 8
4 HP:0003639 Elevated urinary epinephrine 2.522E-5 1.357E-3 9.287E-3 1.326E-2 2 8
5 HP:0003574 Positive regitine blocking test 2.522E-5 1.357E-3 9.287E-3 1.326E-2 2 8
6 HP:0006723 Intestinal carcinoid 3.241E-5 1.357E-3 9.287E-3 1.705E-2 2 9
7 HP:0006737 Extraadrenal pheochromocytoma 3.241E-5 1.357E-3 9.287E-3 1.705E-2 2 9
8 HP:0009712 Tumor of the spinal cord 3.241E-5 1.357E-3 9.287E-3 1.705E-2 2 9
9 HP:0009711 Retinal capillary hemangioma 3.241E-5 1.357E-3 9.287E-3 1.705E-2 2 9
10 HP:0009713 Spinal hemangioblastoma 3.241E-5 1.357E-3 9.287E-3 1.705E-2 2 9
11 HP:0002640 Hypertension associated with pheochromocytoma 4.049E-5 1.357E-3 9.287E-3 2.130E-2 2 10
12 HP:0006880 Cerebellar hemangioblastoma 4.049E-5 1.357E-3 9.287E-3 2.130E-2 2 10
13 HP:0008261 Pancreatic islet cell adenoma 4.049E-5 1.357E-3 9.287E-3 2.130E-2 2 10
14 HP:0030405 Pancreatic endocrine tumor 4.049E-5 1.357E-3 9.287E-3 2.130E-2 2 10
15 HP:0003528 Elevated calcitonin 4.947E-5 1.357E-3 9.287E-3 2.602E-2 2 11
16 HP:0008208 Parathyroid hyperplasia 4.947E-5 1.357E-3 9.287E-3 2.602E-2 2 11
17 HP:0002864 Paraganglioma of head and neck 4.947E-5 1.357E-3 9.287E-3 2.602E-2 2 11
18 HP:0006748 Adrenal pheochromocytoma 4.947E-5 1.357E-3 9.287E-3 2.602E-2 2 11
19 HP:0100642 Neoplasm of the adrenal medulla 4.947E-5 1.357E-3 9.287E-3 2.602E-2 2 11
20 HP:0005234 Neonatal intestinal obstruction 5.934E-5 1.357E-3 9.287E-3 3.121E-2 2 12
21 HP:0002044 Zollinger-Ellison syndrome 5.934E-5 1.357E-3 9.287E-3 3.121E-2 2 12
22 HP:0005241 Total intestinal aganglionosis 5.934E-5 1.357E-3 9.287E-3 3.121E-2 2 12
23 HP:0010448 Colonic atresia 5.934E-5 1.357E-3 9.287E-3 3.121E-2 2 12
24 HP:0011102 Ileal atresia 7.010E-5 1.418E-3 9.705E-3 3.687E-2 2 13
25 HP:0011736 Primary hyperaldosteronism 7.010E-5 1.418E-3 9.705E-3 3.687E-2 2 13
26 HP:0006780 Parathyroid carcinoma 7.010E-5 1.418E-3 9.705E-3 3.687E-2 2 13
27 HP:0011286 Total colonic aganglionosis 8.174E-5 1.433E-3 9.808E-3 4.300E-2 2 14
28 HP:0001095 Hypertensive retinopathy 8.174E-5 1.433E-3 9.808E-3 4.300E-2 2 14
29 HP:0009594 Retinal hamartoma 8.174E-5 1.433E-3 9.808E-3 4.300E-2 2 14
30 HP:0007544 Piebaldism 8.174E-5 1.433E-3 9.808E-3 4.300E-2 2 14
31 HP:0005249 Functional intestinal obstruction 9.428E-5 1.550E-3 1.061E-2 4.959E-2 2 15
32 HP:0010956 Fetal megacystis 9.428E-5 1.550E-3 1.061E-2 4.959E-2 2 15
33 HP:0011979 Elevated urinary dopamine 1.077E-4 1.666E-3 1.140E-2
5.665E-2
 2 16
34 HP:0010797 Hemangioblastoma 1.077E-4 1.666E-3 1.140E-2
5.665E-2
 2 16
35 HP:0008200 Primary hyperparathyroidism 1.533E-4 2.304E-3 1.576E-2
8.063E-2
 2 19
36 HP:0011281 Abnormality of urine catecholamine concentration 1.702E-4 2.420E-3 1.656E-2
8.955E-2
 2 20
37 HP:0011976 Elevated urinary catecholamines 1.702E-4 2.420E-3 1.656E-2
8.955E-2
 2 20
38 HP:0010955 Dilatation of the bladder 1.881E-4 2.603E-3 1.782E-2
9.893E-2
 2 21
39 HP:0007110 Central hypoventilation 2.068E-4 2.789E-3 1.909E-2
1.088E-1
 2 22
40 HP:0004388 Microcolon 2.469E-4 3.020E-3 2.067E-2
1.299E-1
 2 24
41 HP:0010568 Hamartoma of the eye 2.469E-4 3.020E-3 2.067E-2
1.299E-1
 2 24
42 HP:0030670 Hamartoma of the orbital region 2.469E-4 3.020E-3 2.067E-2
1.299E-1
 2 24
43 HP:0006747 Ganglioneuroblastoma 2.469E-4 3.020E-3 2.067E-2
1.299E-1
 2 24
44 HP:0100811 Aplasia/Hypoplasia of the colon 2.682E-4 3.118E-3 2.134E-2
1.411E-1
 2 25
45 HP:0001953 Diabetic ketoacidosis 2.682E-4 3.118E-3 2.134E-2
1.411E-1
 2 25
46 HP:0002580 Volvulus 2.905E-4 3.118E-3 2.134E-2
1.528E-1
 2 26
47 HP:0012620 Cloacal abnormality 2.905E-4 3.118E-3 2.134E-2
1.528E-1
 2 26
48 HP:0009732 Plexiform neurofibroma 2.905E-4 3.118E-3 2.134E-2
1.528E-1
 2 26
49 HP:0010475 Cloacal exstrophy 2.905E-4 3.118E-3 2.134E-2
1.528E-1
 2 26
50 HP:0008256 Adrenocortical adenoma 3.136E-4 3.299E-3 2.257E-2
1.649E-1
 2 27
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 13 input genes in category / 690 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002751 abnormal autonomic nervous system morphology 3.183E-11 1.220E-8 8.679E-8 2.196E-8 7 117
2 MP:0001011 abnormal superior cervical ganglion morphology 3.536E-11 1.220E-8 8.679E-8 2.440E-8 6 57
3 MP:0008317 abnormal paravertebral ganglion morphology 5.972E-11 1.374E-8 9.773E-8 4.121E-8 6 62
4 MP:0001008 abnormal sympathetic ganglion morphology 9.667E-11 1.668E-8 1.186E-7 6.670E-8 6 67
5 MP:0001007 abnormal sympathetic system morphology 2.472E-10 3.412E-8 2.427E-7 1.706E-7 6 78
6 MP:0000964 small dorsal root ganglion 3.027E-10 3.481E-8 2.476E-7 2.088E-7 5 33
7 MP:0001015 small superior cervical ganglion 6.380E-10 6.289E-8 4.474E-7 4.402E-7 5 38
8 MP:0000960 abnormal sensory ganglion morphology 7.654E-9 6.601E-7 4.697E-6 5.281E-6 7 255
9 MP:0000961 abnormal dorsal root ganglion morphology 1.076E-8 8.248E-7 5.868E-6 7.424E-6 6 145
10 MP:0001052 abnormal innervation pattern to muscle 3.066E-7 2.116E-5 1.505E-4 2.116E-4 4 49
11 MP:0001025 abnormal sympathetic neuron morphology 1.041E-6 5.984E-5 4.257E-4 7.180E-4 3 17
12 MP:0003290 intestinal hypoperistalsis 1.041E-6 5.984E-5 4.257E-4 7.180E-4 3 17
13 MP:0008313 abnormal parasympathetic postganglionic fiber morphology 1.455E-6 7.723E-5 5.494E-4 1.004E-3 2 2
14 MP:0000990 abnormal skeletal muscle mechanoreceptor morphology 1.741E-6 8.008E-5 5.697E-4 1.201E-3 3 20
15 MP:0004069 abnormal muscle spindle morphology 1.741E-6 8.008E-5 5.697E-4 1.201E-3 3 20
16 MP:0000939 decreased motor neuron number 2.995E-6 1.292E-4 9.189E-4 2.067E-3 4 86
17 MP:0001344 blepharoptosis 3.953E-6 1.604E-4 1.142E-3 2.728E-3 3 26
18 MP:0003289 abnormal intestinal peristalsis 4.444E-6 1.703E-4 1.212E-3 3.066E-3 3 27
19 MP:0002184 abnormal innervation 8.002E-6 2.847E-4 2.026E-3 5.521E-3 5 246
20 MP:0001046 abnormal enteric neuron morphology 8.253E-6 2.847E-4 2.026E-3 5.695E-3 3 33
21 MP:0001044 abnormal enteric nervous system morphology 1.853E-5 6.089E-4 4.332E-3 1.279E-2 3 43
22 MP:0001021 small L4 dorsal root ganglion 3.045E-5 9.549E-4 6.794E-3 2.101E-2 2 7
23 MP:0001019 abnormal L4 dorsal root ganglion morphology 4.057E-5 1.166E-3 8.298E-3 2.799E-2 2 8
24 MP:0001017 abnormal stellate ganglion morphology 4.057E-5 1.166E-3 8.298E-3 2.799E-2 2 8
25 MP:0001092 abnormal trigeminal ganglion morphology 4.826E-5 1.332E-3 9.476E-3 3.330E-2 3 59
26 MP:0001014 absent superior cervical ganglion 5.212E-5 1.383E-3 9.841E-3 3.596E-2 2 9
27 MP:0000937 abnormal motor neuron morphology 6.348E-5 1.497E-3 1.065E-2 4.380E-2 4 186
28 MP:0011082 abnormal gastrointestinal motility 6.456E-5 1.497E-3 1.065E-2 4.454E-2 3 65
29 MP:0001048 absent enteric neurons 6.511E-5 1.497E-3 1.065E-2 4.492E-2 2 10
30 MP:0001088 small nodose ganglion 6.511E-5 1.497E-3 1.065E-2 4.492E-2 2 10
31 MP:0020491 abnormal ovary topology 7.952E-5 1.715E-3 1.220E-2
5.487E-2
 2 11
32 MP:0001085 small petrosal ganglion 7.952E-5 1.715E-3 1.220E-2
5.487E-2
 2 11
33 MP:0001087 abnormal nodose ganglion morphology 1.126E-4 2.220E-3 1.579E-2
7.770E-2
 2 13
34 MP:0001034 abnormal parasympathetic ganglion morphology 1.126E-4 2.220E-3 1.579E-2
7.770E-2
 2 13
35 MP:0001083 small geniculate ganglion 1.126E-4 2.220E-3 1.579E-2
7.770E-2
 2 13
36 MP:0001081 abnormal cranial ganglia morphology 1.497E-4 2.792E-3 1.987E-2
1.033E-1
 4 232
37 MP:0008503 abnormal spinal cord grey matter morphology 1.497E-4 2.792E-3 1.987E-2
1.033E-1
 4 232
38 MP:0008948 decreased neuron number 1.721E-4 2.982E-3 2.122E-2
1.188E-1
 5 466
39 MP:0010983 abnormal ureteric bud invasion 1.729E-4 2.982E-3 2.122E-2
1.193E-1
 2 16
40 MP:0001084 abnormal petrosal ganglion morphology 1.729E-4 2.982E-3 2.122E-2
1.193E-1
 2 16
41 MP:0001033 abnormal parasympathetic system morphology 1.958E-4 3.295E-3 2.344E-2
1.351E-1
 2 17
42 MP:0001045 abnormal enteric ganglia morphology 2.201E-4 3.616E-3 2.573E-2
1.519E-1
 2 18
43 MP:0006404 abnormal lumbar dorsal root ganglion morphology 2.458E-4 3.945E-3 2.806E-2
1.696E-1
 2 19
44 MP:0003202 abnormal neuron apoptosis 2.722E-4 4.269E-3 3.037E-2
1.878E-1
 4 271
45 MP:0010982 abnormal ureteric bud elongation 3.015E-4 4.622E-3 3.289E-2
2.080E-1
 2 21
46 MP:0001093 small trigeminal ganglion 3.627E-4 5.440E-3 3.871E-2
2.503E-1
 2 23
47 MP:0001082 abnormal geniculate ganglion morphology 3.954E-4 5.804E-3 4.130E-2
2.728E-1
 2 24
48 MP:0003722 absent ureter 4.649E-4 6.683E-3 4.755E-2
3.208E-1
 2 26
49 MP:0002731 megacolon 5.400E-4 7.603E-3
5.410E-2
3.726E-1
 2 28
50 MP:0000955 abnormal spinal cord morphology 6.453E-4 8.905E-3
6.336E-2
4.453E-1
 4 340
Show 45 more annotations

6: Domain [Display Chart] 13 input genes in category / 85 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2.10.90.10 - Gene3D 1.042E-7 4.430E-6 2.226E-5 8.860E-6 4 67
2 IPR029034 Cystine-knot cytokine InterPro 1.042E-7 4.430E-6 2.226E-5 8.860E-6 4 67
3 IPR019846 Nerve growth factor CS InterPro 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
4 PS00248 NGF 1 PROSITE 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
5 SM00140 NGF SMART 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
6 PS50270 NGF 2 PROSITE 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
7 IPR002072 Nerve growth factor-rel InterPro 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
8 PD002052 Nerve growth factor-rel ProDom 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
9 PF00243 NGF Pfam 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
10 IPR020408 Nerve growth factor-like InterPro 2.665E-6 2.265E-5 1.138E-4 2.265E-4 2 4
11 IPR003438 GDNF rcpt InterPro 4.439E-6 3.430E-5 1.724E-4 3.774E-4 2 5
12 PF02351 GDNF Pfam 6.657E-6 4.041E-5 2.031E-4 5.658E-4 2 6
13 SM00907 GDNF SMART 6.657E-6 4.041E-5 2.031E-4 5.658E-4 2 6
14 IPR016017 GDNF/GAS1 InterPro 6.657E-6 4.041E-5 2.031E-4 5.658E-4 2 6
15 SM00219 TyrKc SMART 2.768E-5 1.471E-4 7.391E-4 2.353E-3 3 88
16 IPR020635 Tyr kinase cat dom InterPro 2.768E-5 1.471E-4 7.391E-4 2.353E-3 3 88
17 IPR008266 Tyr kinase AS InterPro 3.706E-5 1.750E-4 8.795E-4 3.150E-3 3 97
18 PS00109 PROTEIN KINASE TYR PROSITE 3.706E-5 1.750E-4 8.795E-4 3.150E-3 3 97
19 PF07714 Pkinase Tyr Pfam 8.672E-5 3.880E-4 1.950E-3 7.372E-3 3 129
20 IPR001245 Ser-Thr/Tyr kinase cat dom InterPro 1.060E-4 4.503E-4 2.263E-3 9.006E-3 3 138
21 PS00250 TGF BETA 1 PROSITE 2.920E-4 9.928E-4 4.989E-3 2.482E-2 2 37
22 IPR001839 TGF-b C InterPro 2.920E-4 9.928E-4 4.989E-3 2.482E-2 2 37
23 PS51362 TGF BETA 2 PROSITE 2.920E-4 9.928E-4 4.989E-3 2.482E-2 2 37
24 PF00019 TGF beta Pfam 2.920E-4 9.928E-4 4.989E-3 2.482E-2 2 37
25 SM00204 TGFB SMART 2.920E-4 9.928E-4 4.989E-3 2.482E-2 2 37
26 1.20.1250.10 - Gene3D 5.343E-4 1.512E-3 7.601E-3 4.542E-2 2 50
27 IPR012351 4 helix cytokine core InterPro 5.559E-4 1.512E-3 7.601E-3 4.725E-2 2 51
28 IPR003504 GDNF rcpt a2 InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
29 PF04622 ERG2 Sigma1R Pfam 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
30 IPR009136 VEGFR2 rcpt InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
31 IPR000151 Ciliary neurotrophic fac CNTF InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
32 IPR029593 Shc3/ShcC/N-Shc InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
33 IPR015578 Neurotrophin-3 InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
34 IPR016649 GDNF InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
35 IPR003505 GDNF rcpt A3 InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
36 IPR006716 ERG2 sigma1 rcpt-like InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
37 IPR016249 Tyr kinase Ret rcpt InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
38 IPR020432 Neurotrophin-4 InterPro 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
39 PF01110 CNTF Pfam 6.939E-4 1.512E-3 7.601E-3
5.898E-2
 1 1
40 IPR009079 4 helix cytokine-like core InterPro 1.167E-3 2.480E-3 1.246E-2
9.921E-2
 2 74
41 SM00080 LIF OSM SMART 1.387E-3 2.564E-3 1.288E-2
1.179E-1
 1 2
42 IPR001581 Leukemia IF/oncostatin InterPro 1.387E-3 2.564E-3 1.288E-2
1.179E-1
 1 2
43 IPR017372 Glial neurotroph fac rcpt a1/2 InterPro 1.387E-3 2.564E-3 1.288E-2
1.179E-1
 1 2
44 PF01291 LIF OSM Pfam 1.387E-3 2.564E-3 1.288E-2
1.179E-1
 1 2
45 PS00590 LIF OSM PROSITE 1.387E-3 2.564E-3 1.288E-2
1.179E-1
 1 2
46 IPR019827 Leukemia IF/oncostatin CS InterPro 1.387E-3 2.564E-3 1.288E-2
1.179E-1
 1 2
47 IPR017441 Protein kinase ATP BS InterPro 2.020E-3 3.653E-3 1.836E-2
1.717E-1
 3 379
48 IPR006019 PID Shc-like InterPro 2.773E-3 4.910E-3 2.468E-2
2.357E-1
 1 4
49 PS00107 PROTEIN KINASE ATP PROSITE 3.479E-3 6.035E-3 3.033E-2
2.957E-1
 3 459
50 IPR000719 Prot kinase dom InterPro 4.158E-3 7.069E-3 3.553E-2
3.534E-1
 3 489
Show 45 more annotations

7: Pathway [Display Chart] 12 input genes in category / 101 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269483 VEGFA-VEGFR2 Pathway BioSystems: REACTOME 1.087E-10 6.635E-9 3.448E-8 1.098E-8 8 333
2 1269480 Signaling by VEGF BioSystems: REACTOME 1.314E-10 6.635E-9 3.448E-8 1.327E-8 8 341
3 1269485 VEGFR2 mediated cell proliferation BioSystems: REACTOME 1.190E-9 4.005E-8 2.081E-7 1.201E-7 7 261
4 1269440 SOS-mediated signalling BioSystems: REACTOME 4.916E-8 4.286E-7 2.228E-6 4.966E-6 6 248
5 1269383 SHC1 events in EGFR signaling BioSystems: REACTOME 4.916E-8 4.286E-7 2.228E-6 4.966E-6 6 248
6 1269382 GRB2 events in EGFR signaling BioSystems: REACTOME 4.916E-8 4.286E-7 2.228E-6 4.966E-6 6 248
7 1269285 RAF/MAP kinase cascade BioSystems: REACTOME 4.916E-8 4.286E-7 2.228E-6 4.966E-6 6 248
8 1269471 ARMS-mediated activation BioSystems: REACTOME 5.408E-8 4.286E-7 2.228E-6 5.462E-6 6 252
9 1269468 Signalling to p38 via RIT and RIN BioSystems: REACTOME 5.408E-8 4.286E-7 2.228E-6 5.462E-6 6 252
10 1269470 Frs2-mediated activation BioSystems: REACTOME 5.537E-8 4.286E-7 2.228E-6 5.592E-6 6 253
11 1269502 MAPK1/MAPK3 signaling BioSystems: REACTOME 5.669E-8 4.286E-7 2.228E-6 5.725E-6 6 254
12 1269469 Prolonged ERK activation events BioSystems: REACTOME 5.803E-8 4.286E-7 2.228E-6 5.861E-6 6 255
13 1269632 Signaling by Leptin BioSystems: REACTOME 5.940E-8 4.286E-7 2.228E-6 5.999E-6 6 256
14 1269322 Interleukin receptor SHC signaling BioSystems: REACTOME 6.221E-8 4.286E-7 2.228E-6 6.283E-6 6 258
15 1269465 Signalling to RAS BioSystems: REACTOME 6.366E-8 4.286E-7 2.228E-6 6.430E-6 6 259
16 1269321 Interleukin-2 signaling BioSystems: REACTOME 7.295E-8 4.432E-7 2.304E-6 7.368E-6 6 265
17 1269464 Signalling to ERKs BioSystems: REACTOME 7.460E-8 4.432E-7 2.304E-6 7.535E-6 6 266
18 1427866 RET signaling BioSystems: REACTOME 8.706E-8 4.493E-7 2.335E-6 8.793E-6 6 273
19 1269299 FCERI mediated MAPK activation BioSystems: REACTOME 8.897E-8 4.493E-7 2.335E-6 8.986E-6 6 274
20 1269323 Interleukin-3, 5 and GM-CSF signaling BioSystems: REACTOME 8.897E-8 4.493E-7 2.335E-6 8.986E-6 6 274
21 1270312 NCAM signaling for neurite out-growth BioSystems: REACTOME 9.905E-8 4.764E-7 2.476E-6 1.000E-5 6 279
22 1269501 MAPK family signaling cascades BioSystems: REACTOME 1.324E-7 6.044E-7 3.141E-6 1.338E-5 6 293
23 1269431 IRS-mediated signalling BioSystems: REACTOME 1.464E-7 6.044E-7 3.141E-6 1.479E-5 6 298
24 1269429 Insulin receptor signalling cascade BioSystems: REACTOME 1.554E-7 6.044E-7 3.141E-6 1.569E-5 6 301
25 1269618 IGF1R signaling cascade BioSystems: REACTOME 1.584E-7 6.044E-7 3.141E-6 1.600E-5 6 302
26 1269620 IRS-related events triggered by IGF1R BioSystems: REACTOME 1.584E-7 6.044E-7 3.141E-6 1.600E-5 6 302
27 1269617 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) BioSystems: REACTOME 1.616E-7 6.044E-7 3.141E-6 1.632E-5 6 303
28 1269428 Signaling by Insulin receptor BioSystems: REACTOME 2.491E-7 8.985E-7 4.670E-6 2.516E-5 6 326
29 1269487 Signaling by SCF-KIT BioSystems: REACTOME 3.193E-7 1.112E-6 5.780E-6 3.225E-5 6 340
30 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 3.421E-7 1.152E-6 5.986E-6 3.455E-5 6 344
31 1269479 Downstream signal transduction BioSystems: REACTOME 4.119E-7 1.342E-6 6.974E-6 4.160E-5 6 355
32 1269284 DAP12 signaling BioSystems: REACTOME 4.400E-7 1.389E-6 7.217E-6 4.444E-5 6 359
33 1269380 Signaling by EGFR BioSystems: REACTOME 5.010E-7 1.533E-6 7.969E-6 5.060E-5 6 367
34 1269283 DAP12 interactions BioSystems: REACTOME 5.599E-7 1.663E-6 8.644E-6 5.655E-5 6 374
35 1269478 Signaling by PDGF BioSystems: REACTOME 6.053E-7 1.747E-6 9.079E-6 6.114E-5 6 379
36 1269298 Fc epsilon receptor (FCERI) signaling BioSystems: REACTOME 6.244E-7 1.752E-6 9.104E-6 6.306E-5 6 381
37 1269460 NGF signalling via TRKA from the plasma membrane BioSystems: REACTOME 7.162E-7 1.955E-6 1.016E-5 7.233E-5 6 390
38 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 1.572E-6 4.178E-6 2.171E-5 1.588E-4 6 446
39 1269443 Signalling by NGF BioSystems: REACTOME 2.503E-6 6.481E-6 3.369E-5 2.528E-4 6 483
40 1270313 NCAM1 interactions BioSystems: REACTOME 5.219E-6 1.318E-5 6.849E-5 5.271E-4 3 37
41 137977 Neurotrophic factor-mediated Trk receptor signaling BioSystems: Pathway Interaction Database 1.843E-5 4.539E-5 2.359E-4 1.861E-3 3 56
42 1404798 EGFR tyrosine kinase inhibitor resistance BioSystems: KEGG 5.192E-5 1.248E-4 6.489E-4 5.244E-3 3 79
43 1339143 IL-6-type cytokine receptor ligand interactions BioSystems: REACTOME 1.603E-4 3.764E-4 1.956E-3 1.619E-2 2 20
44 101143 Neurotrophin signaling pathway BioSystems: KEGG 1.759E-4 4.038E-4 2.098E-3 1.777E-2 3 119
45 1339142 Interleukin-6 family signaling BioSystems: REACTOME 2.950E-4 6.620E-4 3.441E-3 2.979E-2 2 27
46 137915 Signaling events regulated by Ret tyrosine kinase BioSystems: Pathway Interaction Database 5.873E-4 1.289E-3 6.702E-3
5.932E-2
 2 38
47 138019 p75(NTR)-mediated signaling BioSystems: Pathway Interaction Database 1.510E-3 3.245E-3 1.687E-2
1.525E-1
 2 61
48 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 1.919E-3 3.892E-3 2.023E-2
1.938E-1
 3 270
49 PW:0000495 Gas6 - Axl signaling axis Pathway Ontology 1.927E-3 3.892E-3 2.023E-2
1.946E-1
 1 2
50 PW:0000353 altered vascular endothelial growth factor signaling involving proteins affecting its expression Pathway Ontology 1.927E-3 3.892E-3 2.023E-2
1.946E-1
 1 2
Show 45 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 4939 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11003834 Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins. Pubmed 3.990E-17 9.854E-14 8.950E-13 1.971E-13 5 7
2 9448325 Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. Pubmed 3.990E-17 9.854E-14 8.950E-13 1.971E-13 5 7
3 22855506 Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems. Pubmed 1.504E-15 2.476E-12 2.248E-11 7.427E-12 5 12
4 10712625 A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development. Pubmed 1.209E-13 1.195E-10 1.085E-9 5.973E-10 4 6
5 9786421 Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation. Pubmed 1.209E-13 1.195E-10 1.085E-9 5.973E-10 4 6
6 15204970 The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Pubmed 2.821E-13 1.991E-10 1.808E-9 1.394E-9 4 7
7 17322904 Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Pubmed 2.821E-13 1.991E-10 1.808E-9 1.394E-9 4 7
8 10331972 A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation. Pubmed 1.015E-12 6.268E-10 5.693E-9 5.015E-9 4 9
9 10482239 GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion. Pubmed 3.987E-12 2.188E-9 1.987E-8 1.969E-8 4 12
10 12810600 Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Pubmed 8.059E-12 3.980E-9 3.615E-8 3.980E-8 4 14
11 19580811 Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. Pubmed 3.080E-11 1.268E-8 1.151E-7 1.521E-7 3 3
12 18313696 Altered expression of neurotrophic factors in patients with major depression. Pubmed 3.080E-11 1.268E-8 1.151E-7 1.521E-7 3 3
13 9415430 Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis. Pubmed 1.232E-10 3.380E-8 3.070E-7 6.084E-7 3 4
14 23884957 Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain. Pubmed 1.232E-10 3.380E-8 3.070E-7 6.084E-7 3 4
15 17490619 Crosstalk between VEGF-A/VEGFR2 and GDNF/RET signaling pathways. Pubmed 1.232E-10 3.380E-8 3.070E-7 6.084E-7 3 4
16 9749804 GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells. Pubmed 1.232E-10 3.380E-8 3.070E-7 6.084E-7 3 4
17 9452475 Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. Pubmed 1.232E-10 3.380E-8 3.070E-7 6.084E-7 3 4
18 9576965 GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Pubmed 1.232E-10 3.380E-8 3.070E-7 6.084E-7 3 4
19 27571008 Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Pubmed 2.525E-10 5.849E-8 5.312E-7 1.247E-6 4 31
20 10829012 Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
21 10415156 Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
22 9182803 TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
23 9334423 Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
24 25275256 Circulating levels of neurotrophic factors in autism spectrum disorders. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
25 18657279 Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
26 9407096 GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. Pubmed 3.079E-10 5.849E-8 5.312E-7 1.521E-6 3 5
27 23525041 Layer V cortical neurons require microglial support for survival during postnatal development. Pubmed 4.723E-10 8.639E-8 7.846E-7 2.332E-6 4 36
28 16953113 Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease. Pubmed 6.157E-10 1.014E-7 9.206E-7 3.041E-6 3 6
29 10860579 Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development. Pubmed 6.157E-10 1.014E-7 9.206E-7 3.041E-6 3 6
30 12397373 Expression patterns of neurotrophic factor mRNAs in developing human teeth. Pubmed 6.157E-10 1.014E-7 9.206E-7 3.041E-6 3 6
31 25525881 The cellular and molecular basis of direction selectivity of Aδ-LTMRs. Pubmed 1.077E-9 1.612E-7 1.464E-6 5.321E-6 3 7
32 16497798 Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Pubmed 1.077E-9 1.612E-7 1.464E-6 5.321E-6 3 7
33 18417692 Neurturin-mediated ret activation is required for retinal function. Pubmed 1.077E-9 1.612E-7 1.464E-6 5.321E-6 3 7
34 16193506 Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. Pubmed 1.723E-9 2.503E-7 2.274E-6 8.511E-6 3 8
35 12917363 Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion. Pubmed 2.584E-9 3.359E-7 3.051E-6 1.276E-5 3 9
36 12668632 GDNF availability determines enteric neuron number by controlling precursor proliferation. Pubmed 2.584E-9 3.359E-7 3.051E-6 1.276E-5 3 9
37 20139349 Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract. Pubmed 2.584E-9 3.359E-7 3.051E-6 1.276E-5 3 9
38 25838128 Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. Pubmed 2.584E-9 3.359E-7 3.051E-6 1.276E-5 3 9
39 11069590 Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Pubmed 3.691E-9 4.240E-7 3.851E-6 1.823E-5 3 10
40 20219210 Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. Pubmed 3.691E-9 4.240E-7 3.851E-6 1.823E-5 3 10
41 18203754 Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Pubmed 3.691E-9 4.240E-7 3.851E-6 1.823E-5 3 10
42 15748846 GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Pubmed 3.691E-9 4.240E-7 3.851E-6 1.823E-5 3 10
43 18216204 Retrograde signaling onto Ret during motor nerve terminal maturation. Pubmed 3.691E-9 4.240E-7 3.851E-6 1.823E-5 3 10
44 24107967 GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. Pubmed 5.075E-9 5.449E-7 4.949E-6 2.506E-5 3 11
45 18305247 The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. Pubmed 5.075E-9 5.449E-7 4.949E-6 2.506E-5 3 11
46 11044402 Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. Pubmed 5.075E-9 5.449E-7 4.949E-6 2.506E-5 3 11
47 29615468 Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver. Pubmed 1.119E-8 1.176E-6 1.068E-5 5.526E-5 3 14
48 29031500 Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Pubmed 1.313E-8 1.351E-6 1.227E-5 6.487E-5 5 246
49 24516396 Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. Pubmed 1.398E-8 1.381E-6 1.254E-5 6.906E-5 3 15
50 20064391 Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Pubmed 1.398E-8 1.381E-6 1.254E-5 6.906E-5 3 15
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 220 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GDNF GDNF interactions 2.091E-7 2.738E-5 1.635E-4 4.600E-5 3 17
2 int:SHC3 SHC3 interactions 4.083E-7 2.738E-5 1.635E-4 8.983E-5 3 21
3 int:ARTN ARTN interactions 4.978E-7 2.738E-5 1.635E-4 1.095E-4 2 2
4 int:GFRA3 GFRA3 interactions 4.978E-7 2.738E-5 1.635E-4 1.095E-4 2 2
5 int:NTRK2 NTRK2 interactions 2.571E-6 9.379E-5 5.602E-4 5.657E-4 3 38
6 int:GFRA2 GFRA2 interactions 2.984E-6 9.379E-5 5.602E-4 6.566E-4 2 4
7 int:NRTN NRTN interactions 2.984E-6 9.379E-5 5.602E-4 6.566E-4 2 4
8 int:RET RET interactions 1.141E-5 3.138E-4 1.874E-3 2.510E-3 3 62
9 int:GFRA1 GFRA1 interactions 1.390E-5 3.399E-4 2.030E-3 3.059E-3 2 8
10 int:SHC2 SHC2 interactions 5.939E-5 1.307E-3 7.804E-3 1.307E-2 2 16
11 int:BDNF BDNF interactions 9.388E-5 1.878E-3 1.122E-2 2.065E-2 2 20
12 int:LIFR LIFR interactions 1.140E-4 2.091E-3 1.249E-2 2.509E-2 2 22
13 int:SRC SRC interactions 1.638E-4 2.772E-3 1.656E-2 3.604E-2 4 405
14 int:PLCG1 PLCG1 interactions 2.239E-4 3.518E-3 2.101E-2 4.925E-2 3 168
15 int:AXL AXL interactions 2.439E-4 3.568E-3 2.131E-2
5.365E-2
 2 32
16 int:FLT4 FLT4 interactions 2.595E-4 3.568E-3 2.131E-2
5.709E-2
 2 33
17 int:FRS2 FRS2 interactions 3.268E-4 4.229E-3 2.526E-2
7.189E-2
 2 37
18 int:IL6ST IL6ST interactions 4.017E-4 4.909E-3 2.932E-2
8.836E-2
 2 41
19 int:PTPRR PTPRR interactions 4.419E-4 5.117E-3 3.057E-2
9.723E-2
 2 43
20 int:PTPN11 PTPN11 interactions 5.552E-4 6.015E-3 3.593E-2
1.221E-1
 3 229
21 int:GRB10 GRB10 interactions 5.741E-4 6.015E-3 3.593E-2
1.263E-1
 2 49
22 int:CBL CBL interactions 9.056E-4 9.056E-3
5.409E-2
1.992E-1
 3 271
23 int:SHC1 SHC1 interactions 9.750E-4 9.326E-3
5.571E-2
2.145E-1
 3 278
24 int:TMEM204 TMEM204 interactions 2.202E-3 1.863E-2
1.113E-1
4.843E-1
 1 3
25 int:SCUBE2 SCUBE2 interactions 2.202E-3 1.863E-2
1.113E-1
4.843E-1
 1 3
26 int:VEGFC VEGFC interactions 2.202E-3 1.863E-2
1.113E-1
4.843E-1
 1 3
27 int:DOK6 DOK6 interactions 4.399E-3 3.584E-2
2.141E-1
9.677E-1
 1 6
28 int:RANBP9 RANBP9 interactions 4.638E-3 3.641E-2
2.175E-1
1.000E0
 2 141
29 int:TRPM3 TRPM3 interactions 5.130E-3 3.641E-2
2.175E-1
1.000E0
 1 7
30 int:C5orf22 C5orf22 interactions 5.130E-3 3.641E-2
2.175E-1
1.000E0
 1 7
31 int:NTF4 NTF4 interactions 5.130E-3 3.641E-2
2.175E-1
1.000E0
 1 7
32 int:ITIH3 ITIH3 interactions 5.861E-3 4.029E-2
2.407E-1
1.000E0
 1 8
33 int:SHC4 SHC4 interactions 6.591E-3 4.265E-2
2.547E-1
1.000E0
 1 9
34 int:P2RY2 P2RY2 interactions 6.591E-3 4.265E-2
2.547E-1
1.000E0
 1 9
35 int:CNTFR CNTFR interactions 7.321E-3 4.602E-2
2.749E-1
1.000E0
 1 10
36 int:FBXO25 FBXO25 interactions 8.607E-3 4.980E-2
2.975E-1
1.000E0
 2 194
37 int:OSMR OSMR interactions 8.779E-3 4.980E-2
2.975E-1
1.000E0
 1 12
38 int:NTF3 NTF3 interactions 8.779E-3 4.980E-2
2.975E-1
1.000E0
 1 12
39 int:ICA1 ICA1 interactions 9.508E-3 4.980E-2
2.975E-1
1.000E0
 1 13
40 int:VEGFD VEGFD interactions 9.508E-3 4.980E-2
2.975E-1
1.000E0
 1 13
41 int:COL4A4 COL4A4 interactions 9.508E-3 4.980E-2
2.975E-1
1.000E0
 1 13
42 int:TNFRSF25 TNFRSF25 interactions 9.508E-3 4.980E-2
2.975E-1
1.000E0
 1 13
Show 37 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5p13.1-p12 5p13.1-p12 3.751E-4 2.438E-3 7.753E-3 4.876E-3 1 1
2 5q31.1-q31.3 5q31.1-q31.3 3.751E-4 2.438E-3 7.753E-3 4.876E-3 1 1
3 4q11-q12 4q11-q12 1.125E-3 4.874E-3 1.550E-2 1.462E-2 1 3
4 1p33-p32 1p33-p32 3.745E-3 1.217E-2 3.870E-2 4.868E-2 1 10
5 10q11.2 10q11.2 6.358E-3 1.653E-2
5.257E-2
8.266E-2
 1 17
6 9q22.1 9q22.1 7.849E-3 1.701E-2
5.408E-2
1.020E-1
 1 21
7 8p21.3 8p21.3 1.453E-2 2.422E-2
7.701E-2
1.889E-1
 1 39
8 11q12.2 11q12.2 1.490E-2 2.422E-2
7.701E-2
1.937E-1
 1 40
9 19q13.1 19q13.1 2.044E-2 2.893E-2
9.199E-2
2.657E-1
 1 55
10 22q12.2 22q12.2 2.228E-2 2.893E-2
9.199E-2
2.896E-1
 1 60
11 12p13 12p13 2.448E-2 2.893E-2
9.199E-2
3.182E-1
 1 66
12 9p13.3 9p13.3 2.850E-2 3.088E-2
9.820E-2
3.705E-1
 1 77
13 19q13.3 19q13.3 3.106E-2 3.106E-2
9.876E-2
4.037E-1
 1 84
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 11 input genes in category / 190 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 321 Receptor Tyrosine Kinases|Protein phosphatase 1 regulatory subunits genenames.org 1.169E-6 1.169E-5 3.423E-5 1.169E-5 3 40
2 542 Endogenous ligands genenames.org 5.543E-6 1.901E-5 5.567E-5 5.543E-5 4 237
3 1264 Interleukin 6 cytokine family genenames.org 5.702E-6 1.901E-5 5.567E-5 5.702E-5 2 7
4 590 Receptor Tyrosine Kinases|CD molecules|V-set domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 3.424E-3 8.561E-3 2.507E-2 3.424E-2 2 163
5 594 Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing genenames.org 4.763E-3 9.527E-3 2.790E-2 4.763E-2 2 193
6 24 Cadherin related genenames.org 9.307E-3 1.551E-2 4.543E-2
9.307E-2
 1 17
Show 1 more annotation

13: Coexpression [Display Chart] 13 input genes in category / 1047 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 6.373E-8 6.672E-5 5.025E-4 6.672E-5 6 433
2 17638893-SuppTable4 Human Breast Larsson07 14genes GeneSigDB 2.265E-5 1.186E-2
8.931E-2
 2.372E-2 2 13
3 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 9.724E-5 3.381E-2
2.547E-1
1.018E-1
 4 462
4 M2824 Genes down-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL21 [Gene ID=59067]. MSigDB C6: Oncogenic Signatures (v6.0) 1.400E-4 3.381E-2
2.547E-1
1.466E-1
 3 187
5 M7478 Genes up-regulated in periperal blood monocytes (PBMC) from kidney transplant recipients: tolerant versus immunosuppressive therapy. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 3.381E-2
2.547E-1
1.787E-1
 3 200
6 17823238-TableS4a Mouse EmbryonicStemCell Soh07 224genes A GeneSigDB 2.027E-4 3.381E-2
2.547E-1
2.122E-1
 3 212
7 17823238-TableS4b Human EmbryonicStemCell Soh07 224genes B GeneSigDB 2.261E-4 3.381E-2
2.547E-1
2.367E-1
 3 220
Show 2 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 1353 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg5 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg5 BrainMap 8.478E-5 4.396E-2
3.423E-1
1.147E-1
 3 149
2 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.732E-5 4.396E-2
3.423E-1
1.181E-1
 4 424
3 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k1 100 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 9.746E-5 4.396E-2
3.423E-1
1.319E-1
 2 25

15: Computational [Display Chart] 10 input genes in category / 48 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5770 MODULE 63 Porins / transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.610E-5 1.733E-3 7.726E-3 1.733E-3 4 211
2 M19421 MODULE 85 Genes in the cancer module 85. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.110E-3 1.901E-2
8.478E-2
5.327E-2
 2 51
3 M17161 MODULE 199 Genes in the cancer module 199. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.385E-3 1.901E-2
8.478E-2
6.647E-2
 2 57
4 M7888 MODULE 433 Cytokines and GFs. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.585E-3 1.901E-2
8.478E-2
7.606E-2
 2 61

16: MicroRNA [Display Chart] 13 input genes in category / 298 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-147a:Functional MTI Functional MTI miRTarbase 3.247E-4 3.409E-2
2.139E-1
9.676E-2
 2 149
2 hsa-miR-6818-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.835E-4 3.409E-2
2.139E-1
1.143E-1
 2 162
3 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 6.668E-4 3.409E-2
2.139E-1
1.987E-1
 2 214
4 hsa-miR-511-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.879E-4 3.409E-2
2.139E-1
2.944E-1
 2 261
5 hsa-miR-222:PITA hsa-miR-222:PITA TOP PITA 1.056E-3 3.409E-2
2.139E-1
3.148E-1
 2 270
6 hsa-miR-221:PITA hsa-miR-221:PITA TOP PITA 1.080E-3 3.409E-2
2.139E-1
3.218E-1
 2 273
7 hsa-miR-1253:PITA hsa-miR-1253:PITA TOP PITA 1.103E-3 3.409E-2
2.139E-1
3.288E-1
 2 276
8 hsa-miR-34a:PITA hsa-miR-34a:PITA TOP PITA 1.258E-3 3.409E-2
2.139E-1
3.750E-1
 2 295
9 hsa-miR-449a:PITA hsa-miR-449a:PITA TOP PITA 1.258E-3 3.409E-2
2.139E-1
3.750E-1
 2 295
10 hsa-miR-34c-5p:PITA hsa-miR-34c-5p:PITA TOP PITA 1.258E-3 3.409E-2
2.139E-1
3.750E-1
 2 295
11 hsa-miR-449b:PITA hsa-miR-449b:PITA TOP PITA 1.258E-3 3.409E-2
2.139E-1
3.750E-1
 2 295
12 hsa-miR-450a-5p:TargetScan hsa-miR-450a-5p TargetScan 1.439E-3 3.573E-2
2.242E-1
4.288E-1
 1 8
13 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 2.029E-3 4.246E-2
2.665E-1
6.046E-1
 2 376
14 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 2.029E-3 4.246E-2
2.665E-1
6.046E-1
 2 376
15 hsa-miR-33a-5p:TargetScan hsa-miR-33a-5p TargetScan 2.280E-3 4.246E-2
2.665E-1
6.794E-1
 2 399
16 hsa-miR-33b-5p:TargetScan hsa-miR-33b-5p TargetScan 2.280E-3 4.246E-2
2.665E-1
6.794E-1
 2 399
17 hsa-miR-574-5p:Functional MTI Functional MTI miRTarbase 2.463E-3 4.273E-2
2.682E-1
7.338E-1
 2 415
18 hsa-miR-520f:PITA hsa-miR-520f:PITA TOP PITA 2.911E-3 4.273E-2
2.682E-1
8.674E-1
 2 452
19 hsa-miR-1911*:mirSVR highEffct hsa-miR-1911*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.987E-3 4.273E-2
2.682E-1
8.901E-1
 2 458
20 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.000E-3 4.273E-2
2.682E-1
8.939E-1
 2 459
21 hsa-miR-369-3p:TargetScan hsa-miR-369-3p TargetScan 3.025E-3 4.273E-2
2.682E-1
9.015E-1
 2 461
22 ACCAAAG,MIR-9:MSigDB ACCAAAG,MIR-9:MSigDB MSigDB 3.155E-3 4.273E-2
2.682E-1
9.402E-1
 2 471
23 hsa-miR-4304:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.414E-3 4.423E-2
2.776E-1
1.000E0
 1 19
Show 18 more annotations

17: Drug [Display Chart] 13 input genes in category / 4477 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006419759 K00077 Stitch 8.352E-14 3.739E-10 3.359E-9 3.739E-10 8 221
2 CID000013296 4-ethylsulfonylnaphthalene-1-sulfonamide Stitch 3.588E-11 8.031E-8 7.215E-7 1.606E-7 6 123
3 CID000656979 O-Ln Stitch 9.353E-11 1.396E-7 1.254E-6 4.187E-7 5 56
4 CID000036511 Substance P Stitch 2.573E-10 2.880E-7 2.587E-6 1.152E-6 7 343
5 CID000021218 Aliquat 336 Stitch 2.897E-9 2.594E-6 2.330E-5 1.297E-5 4 34
6 CID006441213 LIGA20 Stitch 5.130E-9 3.729E-6 3.350E-5 2.297E-5 4 39
7 ctd:D010862 Pilocarpine CTD 5.830E-9 3.729E-6 3.350E-5 2.610E-5 6 286
8 CID005359521 lissamine Stitch 8.453E-9 4.731E-6 4.250E-5 3.785E-5 4 44
9 CID005326889 AC1NS19J Stitch 1.682E-8 8.365E-6 7.515E-5 7.529E-5 4 52
10 CID000005070 riluzole Stitch 2.967E-8 1.328E-5 1.193E-4 1.328E-4 5 174
11 CID000001401 PD173074 Stitch 4.188E-8 1.705E-5 1.531E-4 1.875E-4 4 65
12 CID000447028 1m0b Stitch 8.788E-8 3.279E-5 2.945E-4 3.934E-4 4 78
13 CID000000290 AC1Q6S1N Stitch 1.790E-7 6.165E-5 5.539E-4 8.015E-4 4 93
14 CID000004624 6-OHDA Stitch 1.995E-7 6.380E-5 5.732E-4 8.932E-4 5 255
15 CID005353676 hydroxystilbamidine Stitch 2.702E-7 8.066E-5 7.246E-4 1.210E-3 4 103
16 CID005289285 Reidispongiolide C Stitch 3.172E-7 8.661E-5 7.781E-4 1.420E-3 5 280
17 CID000068778 budipine Stitch 3.289E-7 8.661E-5 7.781E-4 1.472E-3 3 25
18 CID005289279 RET-RET Stitch 8.968E-7 2.231E-4 2.004E-3 4.015E-3 2 3
19 CID000126565 CEP-701 Stitch 1.754E-6 4.133E-4 3.713E-3 7.853E-3 3 43
20 CID000001066 quinolinic acid Stitch 2.468E-6 5.524E-4 4.963E-3 1.105E-2 4 179
21 CID000005291 imatinib Stitch 2.625E-6 5.597E-4 5.028E-3 1.175E-2 5 430
22 CID000150879 Cys-tyr Stitch 2.987E-6 6.079E-4 5.462E-3 1.337E-2 2 5
23 CID000004422 nalmefene HCl Stitch 3.132E-6 6.097E-4 5.477E-3 1.402E-2 3 52
24 CID000065749 13-methoxyibogamine Stitch 3.513E-6 6.553E-4 5.887E-3 1.573E-2 3 54
25 2890 UP Laudanosine (R,S) [1699-51-0]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.684E-6 6.598E-4 5.928E-3 1.649E-2 4 198
26 CID000000899 N-acetylhexosamine Stitch 4.140E-6 6.685E-4 6.006E-3 1.854E-2 5 472
27 CID000000119 gamma-aminobutyric acid Stitch 4.227E-6 6.685E-4 6.006E-3 1.892E-2 5 474
28 CID000440118 C03789 Stitch 4.364E-6 6.685E-4 6.006E-3 1.954E-2 3 58
29 CID000480137 TAT-4 Stitch 4.480E-6 6.685E-4 6.006E-3 2.006E-2 2 6
30 CID000817373 5-phenylpyrimidine Stitch 4.480E-6 6.685E-4 6.006E-3 2.006E-2 2 6
31 ctd:C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate CTD 4.741E-6 6.847E-4 6.151E-3 2.122E-2 4 211
32 CID006857724 platensimycin Stitch 5.608E-6 7.845E-4 7.048E-3 2.511E-2 3 63
33 CID006456015 sunitinib malate Stitch 5.881E-6 7.979E-4 7.169E-3 2.633E-2 3 64
34 CID000003386 fluoxetine Stitch 6.114E-6 8.020E-4 7.205E-3 2.737E-2 4 225
35 CID006481890 CA-12 Stitch 6.270E-6 8.020E-4 7.205E-3 2.807E-2 2 7
36 CID004369535 P-O-O Stitch 7.384E-6 9.183E-4 8.250E-3 3.306E-2 3 69
37 CID000167969 7 dpo Stitch 8.357E-6 1.011E-3 9.084E-3 3.741E-2 2 8
38 CID000001263 AC1L1B35 Stitch 9.121E-6 1.075E-3 9.654E-3 4.083E-2 3 74
39 CID006338557 O-EC Stitch 9.885E-6 1.135E-3 1.019E-2 4.425E-2 3 76
40 CID000003813 K 252 Stitch 1.537E-5 1.720E-3 1.545E-2
6.881E-2
 3 88
41 CID000164005 Krds peptide Stitch 1.640E-5 1.791E-3 1.609E-2
7.342E-2
 2 11
42 CID003081361 vandetanib Stitch 2.189E-5 2.333E-3 2.096E-2
9.799E-2
 3 99
43 ctd:D006025 Glycosaminoglycans CTD 2.711E-5 2.822E-3 2.536E-2
1.214E-1
 2 14
44 CID000003154 Cosopt Stitch 3.137E-5 3.192E-3 2.868E-2
1.405E-1
 4 341
45 CID000219132 3-Nitrobenzaldoxime Stitch 3.339E-5 3.322E-3 2.985E-2
1.495E-1
 3 114
46 CID000170192 Equithesin Stitch 3.572E-5 3.403E-3 3.057E-2
1.599E-1
 2 16
47 CID000324081 4-anilinoquinazoline Stitch 3.572E-5 3.403E-3 3.057E-2
1.599E-1
 2 16
48 CID000065077 dansylamide Stitch 4.610E-5 4.299E-3 3.863E-2
2.064E-1
 3 127
49 CID005329102 sunitinib Stitch 4.942E-5 4.515E-3 4.057E-2
2.212E-1
 3 130
50 CID000168948 N6-Me-dAdo Stitch 5.086E-5 4.554E-3 4.091E-2
2.277E-1
 2 19
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 770 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0085648 Synovial Cyst DisGeNET BeFree 5.558E-9 2.270E-6 1.640E-5 4.280E-6 6 202
2 C1258666 Myxoid cyst DisGeNET BeFree 5.896E-9 2.270E-6 1.640E-5 4.540E-6 6 204
3 C0085084 Motor Neuron Disease DisGeNET Curated 2.212E-8 5.678E-6 4.102E-5 1.704E-5 5 117
4 C0238462 Medullary carcinoma of thyroid DisGeNET Curated 7.348E-7 1.274E-4 9.207E-4 5.658E-4 5 236
5 C0027796 Neuralgia DisGeNET Curated 8.275E-7 1.274E-4 9.207E-4 6.372E-4 4 97
6 C0442874 Neuropathy DisGeNET Curated 1.402E-6 1.799E-4 1.300E-3 1.079E-3 5 269
7 C0031511 Pheochromocytoma DisGeNET Curated 1.799E-6 1.932E-4 1.396E-3 1.386E-3 5 283
8 C0019569 Hirschsprung Disease DisGeNET Curated 2.007E-6 1.932E-4 1.396E-3 1.546E-3 4 121
9 C2937358 Cerebral Hemorrhage DisGeNET Curated 3.917E-6 3.351E-4 2.421E-3 3.016E-3 3 40
10 OMIN:142623 HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1; HSCR1 OMIM 8.895E-6 5.708E-4 4.123E-3 6.849E-3 2 6
11 cv:C1859049 Congenital central hypoventilation Clinical Variations 8.895E-6 5.708E-4 4.123E-3 6.849E-3 2 6
12 OMIN:209880 AUTONOMIC CONTROL, CONGENITAL FAILURE OF OMIM 8.895E-6 5.708E-4 4.123E-3 6.849E-3 2 6
13 C0035334 Retinitis Pigmentosa DisGeNET Curated 1.075E-5 6.370E-4 4.602E-3 8.281E-3 5 408
14 C0041696 Unipolar Depression DisGeNET Curated 1.209E-5 6.652E-4 4.806E-3 9.313E-3 5 418
15 OMIN:171300 PHEOCHROMOCYTOMA OMIM 1.659E-5 7.514E-4 5.428E-3 1.277E-2 2 8
16 cv:C0031511 Pheochromocytoma Clinical Variations 1.659E-5 7.514E-4 5.428E-3 1.277E-2 2 8
17 C3805839 Central hypoventilation DisGeNET Curated 1.659E-5 7.514E-4 5.428E-3 1.277E-2 2 8
18 C0030193 Pain DisGeNET Curated 2.177E-5 9.311E-4 6.727E-3 1.676E-2 5 472
19 C1862941 Amyotrophic Lateral Sclerosis, Sporadic DisGeNET BeFree 2.428E-5 9.842E-4 7.110E-3 1.870E-2 3 73
20 C1832160 Poor temperature regulation DisGeNET Curated 2.664E-5 1.020E-3 7.367E-3 2.051E-2 2 10
21 C0009241 Cognition Disorders DisGeNET Curated 2.781E-5 1.020E-3 7.367E-3 2.142E-2 4 235
22 C0865424 Adult attention deficit hyperactivity disorder DisGeNET BeFree 3.254E-5 1.139E-3 8.228E-3 2.506E-2 2 11
23 C0005904 Body Temperature Changes DisGeNET Curated 4.611E-5 1.544E-3 1.115E-2 3.550E-2 2 13
24 C0026633 Mouth Abnormalities DisGeNET Curated 5.377E-5 1.656E-3 1.196E-2 4.140E-2 2 14
25 C1609433 Congenital absence of kidneys syndrome DisGeNET Curated 5.377E-5 1.656E-3 1.196E-2 4.140E-2 2 14
26 C0032000 Pituitary Adenoma DisGeNET Curated 5.829E-5 1.726E-3 1.247E-2 4.489E-2 4 284
27 C0020429 Hyperalgesia DisGeNET Curated 8.509E-5 2.427E-3 1.753E-2
6.552E-2
 3 111
28 C0036220 Kaposi Sarcoma DisGeNET Curated 9.609E-5 2.576E-3 1.861E-2
7.399E-2
 4 323
29 C0028043 Nicotine Dependence DisGeNET BeFree 9.701E-5 2.576E-3 1.861E-2
7.470E-2
 3 116
30 C0027746 Nerve Degeneration DisGeNET Curated 1.073E-4 2.754E-3 1.989E-2
8.261E-2
 3 120
31 C0038220 Status Epilepticus DisGeNET Curated 1.127E-4 2.778E-3 2.007E-2
8.677E-2
 3 122
32 C0000737 Abdominal Pain DisGeNET Curated 1.154E-4 2.778E-3 2.007E-2
8.890E-2
 3 123
33 C0281361 Adenocarcinoma of pancreas DisGeNET Curated 1.226E-4 2.801E-3 2.024E-2
9.440E-2
 4 344
34 C0206657 Alveolar Soft Part Sarcoma DisGeNET Curated 1.237E-4 2.801E-3 2.024E-2
9.524E-2
 2 21
35 C0024232 Lymphatic Metastasis DisGeNET Curated 1.330E-4 2.909E-3 2.101E-2
1.024E-1
 3 129
36 C0270911 Charcot-Marie-Tooth Disease, Type Ia (disorder) DisGeNET Curated 1.360E-4 2.909E-3 2.101E-2
1.047E-1
 2 22
37 C0086132 Depressive Symptoms DisGeNET Curated 1.521E-4 3.122E-3 2.256E-2
1.171E-1
 3 135
38 C0233514 Abnormal behavior DisGeNET Curated 1.541E-4 3.122E-3 2.256E-2
1.187E-1
 4 365
39 C0042373 Vascular Diseases DisGeNET Curated 1.590E-4 3.140E-3 2.268E-2
1.225E-1
 4 368
40 C0042063 Urogenital Abnormalities DisGeNET Curated 1.764E-4 3.313E-3 2.393E-2
1.358E-1
 2 25
41 C1855900 HYPERTRICHOSIS, CONGENITAL GENERALIZED DisGeNET Curated 1.764E-4 3.313E-3 2.393E-2
1.358E-1
 2 25
42 C1275808 Congenital central hypoventilation DisGeNET Curated 2.062E-4 3.780E-3 2.731E-2
1.588E-1
 2 27
43 C0021843 Intestinal Obstruction DisGeNET Curated 2.219E-4 3.974E-3 2.871E-2
1.709E-1
 2 28
44 C4048306 Multiple endocrine neoplasia Type 2 DisGeNET BeFree 2.383E-4 4.077E-3 2.945E-2
1.835E-1
 2 29
45 C0025160 Megacolon DisGeNET Curated 2.383E-4 4.077E-3 2.945E-2
1.835E-1
 2 29
46 C0278688 Stage IV Ovarian Carcinoma DisGeNET BeFree 3.285E-4 5.499E-3 3.972E-2
2.529E-1
 2 34
47 C0393819 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating DisGeNET BeFree 3.482E-4 5.705E-3 4.122E-2
2.681E-1
 2 35
48 C1833921 Familial medullary thyroid carcinoma DisGeNET Curated 3.686E-4 5.792E-3 4.184E-2
2.838E-1
 2 36
49 C1619700 RENAL ADYSPLASIA DisGeNET Curated 3.686E-4 5.792E-3 4.184E-2
2.838E-1
 2 36
50 C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 4.393E-4 6.766E-3 4.888E-2
3.383E-1
 4 480
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