Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc55_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 17 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0046923 ER retention sequence binding 1.846E-10 3.139E-9 1.080E-8 3.139E-9 3 5
2 GO:0005046 KDEL sequence binding 8.615E-8 7.323E-7 2.519E-6 1.465E-6 2 2
3 GO:0005048 signal sequence binding 2.110E-7 1.196E-6 4.113E-6 3.588E-6 3 42
4 GO:0042277 peptide binding 6.328E-5 2.689E-4 9.250E-4 1.076E-3 3 278
5 GO:0033218 amide binding 8.666E-5 2.947E-4 1.013E-3 1.473E-3 3 309
6 GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity 6.430E-4 1.822E-3 6.266E-3 1.093E-2 1 2
Show 1 more annotation

2: GO: Biological Process [Display Chart] 6 input genes in category / 29 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006621 protein retention in ER lumen 1.560E-9 3.231E-8 1.280E-7 4.523E-8 3 9
2 GO:0035437 maintenance of protein localization in endoplasmic reticulum 2.228E-9 3.231E-8 1.280E-7 6.461E-8 3 10
3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 4.469E-9 4.320E-8 1.712E-7 1.296E-7 4 79
4 GO:0072595 maintenance of protein localization in organelle 7.520E-8 5.452E-7 2.160E-6 2.181E-6 3 30
5 GO:0051220 cytoplasmic sequestering of protein 2.806E-7 1.628E-6 6.448E-6 8.138E-6 3 46
6 GO:0048193 Golgi vesicle transport 1.591E-6 7.689E-6 3.046E-5 4.613E-5 4 340
7 GO:0032507 maintenance of protein location in cell 2.544E-6 1.054E-5 4.175E-5 7.376E-5 3 95
8 GO:0045185 maintenance of protein location 3.540E-6 1.207E-5 4.782E-5 1.027E-4 3 106
9 GO:0051651 maintenance of location in cell 3.746E-6 1.207E-5 4.782E-5 1.086E-4 3 108
10 GO:0070972 protein localization to endoplasmic reticulum 5.818E-6 1.687E-5 6.684E-5 1.687E-4 3 125
11 GO:0051235 maintenance of location 9.319E-5 2.457E-4 9.733E-4 2.702E-3 3 316
12 GO:0006888 ER to Golgi vesicle-mediated transport 1.329E-3 3.211E-3 1.272E-2 3.853E-2 2 178
13 GO:0051683 establishment of Golgi localization 2.253E-3 5.027E-3 1.992E-2
6.535E-2
 1 7
14 GO:0051645 Golgi localization 4.182E-3 8.662E-3 3.432E-2
1.213E-1
 1 13
15 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 6.427E-3 1.165E-2 4.615E-2
1.864E-1
 1 20
16 GO:0006488 dolichol-linked oligosaccharide biosynthetic process 6.427E-3 1.165E-2 4.615E-2
1.864E-1
 1 20
17 GO:0072384 organelle transport along microtubule 2.076E-2 3.447E-2
1.366E-1
6.021E-1
 1 65
18 GO:0036498 IRE1-mediated unfolded protein response 2.140E-2 3.447E-2
1.366E-1
6.205E-1
 1 67
Show 13 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 15 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030133 transport vesicle 2.121E-6 3.182E-5 1.056E-4 3.182E-5 4 374
2 GO:0030663 COPI-coated vesicle membrane 1.121E-5 8.405E-5 2.789E-4 1.681E-4 2 17
3 GO:0030137 COPI-coated vesicle 2.083E-5 1.042E-4 3.456E-4 3.125E-4 2 23
4 GO:0005801 cis-Golgi network 6.087E-5 2.283E-4 7.575E-4 9.131E-4 2 39
5 GO:0030660 Golgi-associated vesicle membrane 1.130E-4 3.389E-4 1.125E-3 1.695E-3 2 53
6 GO:0005798 Golgi-associated vesicle 2.983E-4 6.745E-4 2.238E-3 4.474E-3 2 86
7 GO:0017090 meprin A complex 3.148E-4 6.745E-4 2.238E-3 4.722E-3 1 1
8 GO:0030662 coated vesicle membrane 8.106E-4 1.520E-3 5.043E-3 1.216E-2 2 142
9 GO:0030135 coated vesicle 2.309E-3 3.849E-3 1.277E-2 3.464E-2 2 241
10 GO:0030126 COPI vesicle coat 4.086E-3 6.129E-3 2.034E-2
6.129E-2
 1 13
11 GO:0030120 vesicle coat 1.502E-2 2.048E-2
6.795E-2
2.252E-1
 1 48
12 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 1.967E-2 2.459E-2
8.159E-2
2.951E-1
 1 63
13 GO:0030117 membrane coat 2.954E-2 3.165E-2
1.050E-1
4.431E-1
 1 95
14 GO:0048475 coated membrane 2.954E-2 3.165E-2
1.050E-1
4.431E-1
 1 95
15 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 3.291E-2 3.291E-2
1.092E-1
4.937E-1
 1 106
Show 10 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 43 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003642 Type I transferrin isoform profile 3.612E-3 2.460E-2
1.070E-1
1.553E-1
 1 17
2 HP:0003160 Abnormal isoelectric focusing of serum transferrin 5.311E-3 2.460E-2
1.070E-1
2.284E-1
 1 25
3 HP:0012469 Infantile spasms 5.311E-3 2.460E-2
1.070E-1
2.284E-1
 1 25
4 HP:0012347 Abnormal protein N-linked glycosylation 5.524E-3 2.460E-2
1.070E-1
2.375E-1
 1 26
5 HP:0012346 Abnormal protein glycosylation 5.524E-3 2.460E-2
1.070E-1
2.375E-1
 1 26
6 HP:0002312 Clumsiness 5.736E-3 2.460E-2
1.070E-1
2.467E-1
 1 27
7 HP:0000331 Short chin 5.736E-3 2.460E-2
1.070E-1
2.467E-1
 1 27
8 HP:0000817 Poor eye contact 5.949E-3 2.460E-2
1.070E-1
2.558E-1
 1 28
9 HP:0012345 Abnormal glycosylation 6.161E-3 2.460E-2
1.070E-1
2.649E-1
 1 29
10 HP:0002421 Poor head control 6.161E-3 2.460E-2
1.070E-1
2.649E-1
 1 29
11 HP:0030047 Abnormality of lateral ventricle 7.223E-3 2.460E-2
1.070E-1
3.106E-1
 1 34
12 HP:0002283 Global brain atrophy 7.436E-3 2.460E-2
1.070E-1
3.197E-1
 1 35
13 HP:0000666 Horizontal nystagmus 7.436E-3 2.460E-2
1.070E-1
3.197E-1
 1 35
14 HP:0011097 Epileptic spasms 1.020E-2 3.132E-2
1.362E-1
4.385E-1
 1 48
15 HP:0000735 Impaired social interactions 1.147E-2 3.254E-2
1.416E-1
4.933E-1
 1 54
16 HP:0001181 Adducted thumb 1.211E-2 3.254E-2
1.416E-1
5.207E-1
 1 57
17 HP:0012433 Abnormal social behavior 1.317E-2 3.332E-2
1.449E-1
5.664E-1
 1 62
18 HP:0002521 Hypsarrhythmia 1.445E-2 3.451E-2
1.501E-1
6.212E-1
 1 68
19 HP:0012448 Delayed myelination 1.806E-2 4.020E-2
1.749E-1
7.765E-1
 1 85
20 HP:0011198 EEG with generalized epileptiform discharges 1.870E-2 4.020E-2
1.749E-1
8.039E-1
 1 88
21 HP:0011182 Interictal epileptiform activity 1.997E-2 4.089E-2
1.779E-1
8.587E-1
 1 94
Show 16 more annotations

5: Mouse Phenotype [Display Chart] 3 input genes in category / 89 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 54 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00951 ER LUMEN RECEPTOR 1 PROSITE 1.825E-11 2.464E-10 1.127E-9 9.856E-10 3 3
2 PF00810 ER lumen recept Pfam 1.825E-11 2.464E-10 1.127E-9 9.856E-10 3 3
3 PS00952 ER LUMEN RECEPTOR 2 PROSITE 1.825E-11 2.464E-10 1.127E-9 9.856E-10 3 3
4 IPR000133 ER ret rcpt InterPro 1.825E-11 2.464E-10 1.127E-9 9.856E-10 3 3
5 IPR007235 Glyco trans 28 C InterPro 3.203E-4 2.660E-3 1.217E-2 1.729E-2 1 1
6 PF04101 Glyco tran 28 C Pfam 3.203E-4 2.660E-3 1.217E-2 1.729E-2 1 1
7 IPR032154 Coatomer g Cpla InterPro 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
8 2.60.40.1480 - Gene3D 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
9 PF08752 COP-gamma platf Pfam 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
10 IPR017106 Coatomer gsu InterPro 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
11 PF16381 Coatomer g Cpla Pfam 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
12 IPR013040 Coatomer gsu app Ig-like-sub InterPro 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
13 IPR008294 Meprin InterPro 6.404E-4 2.660E-3 1.217E-2 3.458E-2 1 2
14 3.30.310.30 - Gene3D 1.281E-3 4.610E-3 2.109E-2
6.915E-2
 1 4
15 IPR015873 Clathrin a/coatomer app sub C InterPro 1.281E-3 4.610E-3 2.109E-2
6.915E-2
 1 4
16 PF01400 Astacin Pfam 1.920E-3 6.100E-3 2.791E-2
1.037E-1
 1 6
17 IPR001506 Peptidase M12A InterPro 1.920E-3 6.100E-3 2.791E-2
1.037E-1
 1 6
18 IPR009028 Coatomer/calthrin app sub C InterPro 2.560E-3 7.679E-3 3.513E-2
1.382E-1
 1 8
19 PS50144 MATH PROSITE 3.837E-3 8.928E-3 4.085E-2
2.072E-1
 1 12
20 PF00917 MATH Pfam 3.837E-3 8.928E-3 4.085E-2
2.072E-1
 1 12
21 IPR013041 Coatomer/clathrin app Ig-like InterPro 3.837E-3 8.928E-3 4.085E-2
2.072E-1
 1 12
22 SM00061 MATH SMART 3.837E-3 8.928E-3 4.085E-2
2.072E-1
 1 12
23 IPR002083 MATH/TRAF dom InterPro 3.837E-3 8.928E-3 4.085E-2
2.072E-1
 1 12
24 PF02338 OTU Pfam 4.157E-3 8.928E-3 4.085E-2
2.245E-1
 1 13
25 2.60.210.10 - Gene3D 4.476E-3 8.928E-3 4.085E-2
2.417E-1
 1 14
26 PS50802 OTU PROSITE 4.795E-3 8.928E-3 4.085E-2
2.589E-1
 1 15
27 IPR003323 OTU dom InterPro 4.795E-3 8.928E-3 4.085E-2
2.589E-1
 1 15
28 PF01602 Adaptin N Pfam 4.795E-3 8.928E-3 4.085E-2
2.589E-1
 1 15
29 IPR002553 Clathrin/coatomer adapt-like N InterPro 4.795E-3 8.928E-3 4.085E-2
2.589E-1
 1 15
30 PS00740 MAM 1 PROSITE 5.114E-3 9.135E-3 4.180E-2
2.761E-1
 1 16
31 SM00137 MAM SMART 5.433E-3 9.135E-3 4.180E-2
2.934E-1
 1 17
32 PF00629 MAM Pfam 5.752E-3 9.135E-3 4.180E-2
3.106E-1
 1 18
33 PS50060 MAM 2 PROSITE 5.752E-3 9.135E-3 4.180E-2
3.106E-1
 1 18
34 IPR000998 MAM dom InterPro 5.752E-3 9.135E-3 4.180E-2
3.106E-1
 1 18
35 PS50304 TUDOR PROSITE 7.344E-3 1.133E-2
5.185E-2
3.966E-1
 1 23
36 IPR008974 TRAF-like InterPro 7.663E-3 1.149E-2
5.259E-2
4.138E-1
 1 24
37 SM00235 ZnMc SMART 9.253E-3 1.315E-2
6.016E-2
4.997E-1
 1 29
38 IPR006026 Peptidase Metallo InterPro 9.253E-3 1.315E-2
6.016E-2
4.997E-1
 1 29
39 IPR002999 Tudor InterPro 9.571E-3 1.325E-2
6.063E-2
5.168E-1
 1 30
40 PS50077 HEAT REPEAT PROSITE 2.221E-2 2.999E-2
1.372E-1
1.000E0
 1 70
41 IPR024079 MetalloPept cat dom InterPro 2.567E-2 3.300E-2
1.510E-1
1.000E0
 1 81
42 3.40.390.10 - Gene3D 2.567E-2 3.300E-2
1.510E-1
1.000E0
 1 81
43 PS00142 ZINC PROTEASE PROSITE 3.098E-2 3.891E-2
1.780E-1
1.000E0
 1 98
44 PF00008 EGF Pfam 3.969E-2 4.870E-2
2.228E-1
1.000E0
 1 126
Show 39 more annotations

7: Pathway [Display Chart] 6 input genes in category / 18 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1339109 COPI-mediated anterograde transport BioSystems: REACTOME 2.231E-8 2.145E-7 7.498E-7 4.015E-7 4 79
2 1383042 COPI-dependent Golgi-to-ER retrograde traffic BioSystems: REACTOME 2.727E-8 2.145E-7 7.498E-7 4.908E-7 4 83
3 1268714 Asparagine N-linked glycosylation BioSystems: REACTOME 3.576E-8 2.145E-7 7.498E-7 6.436E-7 5 285
4 M2482 ADP-Ribosylation Factor MSigDB C2 BIOCARTA (v6.0) 5.062E-8 2.278E-7 7.961E-7 9.111E-7 3 18
5 1383041 Golgi-to-ER retrograde transport BioSystems: REACTOME 8.855E-8 3.188E-7 1.114E-6 1.594E-6 4 111
6 1268726 ER to Golgi Anterograde Transport BioSystems: REACTOME 1.893E-7 5.679E-7 1.985E-6 3.407E-6 4 134
7 1268725 Transport to the Golgi and subsequent modification BioSystems: REACTOME 4.371E-7 1.124E-6 3.929E-6 7.869E-6 4 165
8 1383038 Intra-Golgi and retrograde Golgi-to-ER traffic BioSystems: REACTOME 6.198E-7 1.395E-6 4.874E-6 1.116E-5 4 180
9 83101 Vibrio cholerae infection BioSystems: KEGG 1.284E-6 2.568E-6 8.976E-6 2.311E-5 3 51
10 142200 dolichyl-diphosphooligosaccharide biosynthesis BioSystems: BIOCYC 4.330E-3 7.795E-3 2.724E-2
7.795E-2
 1 9
11 413361 N-glycan precursor biosynthesis BioSystems: KEGG 6.729E-3 1.101E-2 3.849E-2
1.211E-1
 1 14
12 82975 N-Glycan biosynthesis BioSystems: KEGG 2.339E-2 3.508E-2
1.226E-1
4.210E-1
 1 49
13 1268760 XBP1(S) activates chaperone genes BioSystems: REACTOME 2.716E-2 3.613E-2
1.263E-1
4.889E-1
 1 57
14 1268759 IRE1alpha activates chaperones BioSystems: REACTOME 2.810E-2 3.613E-2
1.263E-1
5.059E-1
 1 59
15 1268715 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BioSystems: REACTOME 3.701E-2 4.442E-2
1.552E-1
6.662E-1
 1 78
16 172847 Protein digestion and absorption BioSystems: KEGG 4.261E-2 4.659E-2
1.628E-1
7.669E-1
 1 90
17 1268756 Unfolded Protein Response (UPR) BioSystems: REACTOME 4.400E-2 4.659E-2
1.628E-1
7.920E-1
 1 93
Show 12 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 189 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9118249 The dynamic organisation of the secretory pathway. Pubmed 2.154E-12 4.071E-10 2.370E-9 4.071E-10 3 3
2 25682866 A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation. Pubmed 2.057E-8 1.944E-6 1.131E-5 3.887E-6 2 2
3 19474315 UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Pubmed 1.870E-6 1.178E-4 6.858E-4 3.534E-4 2 14
4 24501762 X chromosome exome sequencing reveals a novel ALG13 mutation in a nonsyndromic intellectual disability family with multiple affected male siblings. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
5 11018518 Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
6 12437102 Zinc ligands in an astacin family metalloprotease meprin A. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
7 19262505 MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
8 9186525 Assignment of Mep 1a to mouse chromosome band 17C1-D1 by in situ hybridization. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
9 17040911 Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
10 26081938 KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
11 15340063 Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
12 1939172 The astacin family of metalloendopeptidases. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
13 23934111 De novo mutations in epileptic encephalopathies. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
14 22096485 Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
15 17377510 Role of meprin A in renal tubular epithelial cell injury. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
16 2172835 A human homologue of the yeast HDEL receptor. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
17 1310258 Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
18 9161413 Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunit. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
19 1325562 Sequence of a second human KDEL receptor. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
20 8392934 Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
21 1316805 A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
22 12888571 Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
23 22492991 Gene identification in the congenital disorders of glycosylation type I by whole-exome sequencing. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
24 10898933 Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
25 8615815 Characterization of the soluble, secreted form of urinary meprin. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
26 11301339 Multimeric structure of the secreted meprin A metalloproteinase and characterization of the functional protomer. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
27 25117681 Control systems of membrane transport at the interface between the endoplasmic reticulum and the Golgi. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
28 28178702 Dysregulation of the Expression of Asparagine-Linked Glycosylation 13 Short Isoform 2 Affects Nephrin Function by Altering Its N-Linked Glycosylation. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
29 1883833 Mapping the active site of meprin-A with peptide substrates and inhibitors. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
30 21684323 The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
31 24781210 The genetic landscape of infantile spasms. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
32 10348167 Composition of the peptide fraction in human blood plasma: database of circulating human peptides. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
33 28778787 Exome sequence identified a c.320A > G ALG13 variant in a female with infantile epileptic encephalopathy with normal glycosylation and random X inactivation: Review of the literature. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
34 23427141 Meprin A metalloproteinase and its role in acute kidney injury. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
35 24388959 Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
36 12821650 The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
37 26138355 Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
38 27378469 Metalloproteases meprin-É? (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
39 23873287 Regulation of Golgi signaling and trafficking by the KDEL receptor. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
40 30235485 Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
41 23804454 Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
42 12071860 Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
43 26861384 A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
44 28646128 γ-COPI mediates the retention of kAE1 G701D protein in Golgi apparatus - a mechanistic explanation of distal renal tubular acidosis associated with the G701D mutation. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
45 8508794 Implications of the three-dimensional structure of astacin for the structure and function of the astacin family of zinc-endopeptidases. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
46 25569479 Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast. Pubmed 1.571E-4 6.455E-4 3.758E-3 2.969E-2 1 1
47 17823376 Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Pubmed 3.142E-4 6.905E-4 4.020E-3
5.938E-2
 1 2
48 19110362 Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells. Pubmed 3.142E-4 6.905E-4 4.020E-3
5.938E-2
 1 2
49 12975382 Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum. Pubmed 3.142E-4 6.905E-4 4.020E-3
5.938E-2
 1 2
50 14690497 Gamma-COP appendage domain - structure and function. Pubmed 3.142E-4 6.905E-4 4.020E-3
5.938E-2
 1 2
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 181 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SERINC3 SERINC3 interactions 6.309E-6 1.142E-3 6.598E-3 1.142E-3 2 12
2 int:COPB1 COPB1 interactions 5.344E-4 3.284E-2
1.898E-1
9.672E-2
 2 107
3 int:ARF1 ARF1 interactions 5.444E-4 3.284E-2
1.898E-1
9.853E-2
 2 108
4 int:GRP GRP interactions 1.694E-3 3.894E-2
2.250E-1
3.066E-1
 1 5
5 int:COPZ2 COPZ2 interactions 1.694E-3 3.894E-2
2.250E-1
3.066E-1
 1 5
6 int:SCT SCT interactions 1.694E-3 3.894E-2
2.250E-1
3.066E-1
 1 5
7 int:PTH PTH interactions 2.370E-3 3.894E-2
2.250E-1
4.291E-1
 1 7
8 int:CCK CCK interactions 2.370E-3 3.894E-2
2.250E-1
4.291E-1
 1 7
9 int:GCG GCG interactions 3.047E-3 3.894E-2
2.250E-1
5.515E-1
 1 9
10 int:GNRH1 GNRH1 interactions 3.385E-3 3.894E-2
2.250E-1
6.127E-1
 1 10
11 int:NTS NTS interactions 3.385E-3 3.894E-2
2.250E-1
6.127E-1
 1 10
12 int:TAC1 TAC1 interactions 3.723E-3 3.894E-2
2.250E-1
6.738E-1
 1 11
13 int:FAM204A FAM204A interactions 3.723E-3 3.894E-2
2.250E-1
6.738E-1
 1 11
14 int:TCEAL9 TCEAL9 interactions 3.723E-3 3.894E-2
2.250E-1
6.738E-1
 1 11
15 int:MINDY1 MINDY1 interactions 4.061E-3 3.894E-2
2.250E-1
7.350E-1
 1 12
16 int:VIP VIP interactions 4.399E-3 3.894E-2
2.250E-1
7.961E-1
 1 13
17 int:TMEM56 TMEM56 interactions 4.399E-3 3.894E-2
2.250E-1
7.961E-1
 1 13
18 int:MEP1B MEP1B interactions 4.736E-3 3.894E-2
2.250E-1
8.573E-1
 1 14
19 int:TTYH2 TTYH2 interactions 5.074E-3 3.894E-2
2.250E-1
9.184E-1
 1 15
20 int:ARHGEF10 ARHGEF10 interactions 5.074E-3 3.894E-2
2.250E-1
9.184E-1
 1 15
21 int:EGFL6 EGFL6 interactions 5.411E-3 3.894E-2
2.250E-1
9.795E-1
 1 16
22 int:DRD1 DRD1 interactions 5.411E-3 3.894E-2
2.250E-1
9.795E-1
 1 16
23 int:PLSCR4 PLSCR4 interactions 5.411E-3 3.894E-2
2.250E-1
9.795E-1
 1 16
24 int:NPY NPY interactions 5.411E-3 3.894E-2
2.250E-1
9.795E-1
 1 16
25 int:TAPBP TAPBP interactions 6.086E-3 3.894E-2
2.250E-1
1.000E0
 1 18
26 int:KDELR3 KDELR3 interactions 6.760E-3 3.894E-2
2.250E-1
1.000E0
 1 20
27 int:CCDC107 CCDC107 interactions 6.760E-3 3.894E-2
2.250E-1
1.000E0
 1 20
28 int:ALG13 ALG13 interactions 6.760E-3 3.894E-2
2.250E-1
1.000E0
 1 20
29 int:CD74 CD74 interactions 7.097E-3 3.894E-2
2.250E-1
1.000E0
 1 21
30 int:POMC POMC interactions 7.097E-3 3.894E-2
2.250E-1
1.000E0
 1 21
31 int:PPBP PPBP interactions 7.434E-3 3.894E-2
2.250E-1
1.000E0
 1 22
32 int:SACM1L SACM1L interactions 7.434E-3 3.894E-2
2.250E-1
1.000E0
 1 22
33 int:RHOQ RHOQ interactions 7.771E-3 3.894E-2
2.250E-1
1.000E0
 1 23
34 int:MEP1A MEP1A interactions 7.771E-3 3.894E-2
2.250E-1
1.000E0
 1 23
35 int:LPCAT3 LPCAT3 interactions 8.444E-3 3.894E-2
2.250E-1
1.000E0
 1 25
36 int:DPEP2 DPEP2 interactions 8.444E-3 3.894E-2
2.250E-1
1.000E0
 1 25
37 int:ERGIC2 ERGIC2 interactions 8.781E-3 3.894E-2
2.250E-1
1.000E0
 1 26
38 int:KCNJ10 KCNJ10 interactions 8.781E-3 3.894E-2
2.250E-1
1.000E0
 1 26
39 int:AGPAT3 AGPAT3 interactions 9.117E-3 3.894E-2
2.250E-1
1.000E0
 1 27
40 int:AGT AGT interactions 9.454E-3 3.894E-2
2.250E-1
1.000E0
 1 28
41 int:FGFRL1 FGFRL1 interactions 9.454E-3 3.894E-2
2.250E-1
1.000E0
 1 28
42 int:SLC4A2 SLC4A2 interactions 9.454E-3 3.894E-2
2.250E-1
1.000E0
 1 28
43 int:TRAFD1 TRAFD1 interactions 9.790E-3 3.894E-2
2.250E-1
1.000E0
 1 29
44 int:GLRA2 GLRA2 interactions 1.013E-2 3.894E-2
2.250E-1
1.000E0
 1 30
45 int:KDELR1 KDELR1 interactions 1.013E-2 3.894E-2
2.250E-1
1.000E0
 1 30
46 int:ALG8 ALG8 interactions 1.013E-2 3.894E-2
2.250E-1
1.000E0
 1 30
47 int:LAMA5 LAMA5 interactions 1.046E-2 3.894E-2
2.250E-1
1.000E0
 1 31
48 int:RERE RERE interactions 1.080E-2 3.894E-2
2.250E-1
1.000E0
 1 32
49 int:PITX1 PITX1 interactions 1.147E-2 3.894E-2
2.250E-1
1.000E0
 1 34
50 int:INTS12 INTS12 interactions 1.181E-2 3.894E-2
2.250E-1
1.000E0
 1 35
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p12-p11 6p12-p11 3.462E-4 2.077E-3 5.089E-3 2.077E-3 1 2
2 7p22.1 7p22.1 8.281E-3 1.371E-2 3.359E-2 4.969E-2 1 48
3 Xq23 Xq23 8.968E-3 1.371E-2 3.359E-2
5.381E-2
 1 52
4 3q21.3 3q21.3 9.140E-3 1.371E-2 3.359E-2
5.484E-2
 1 53
5 19q13.3 19q13.3 1.445E-2 1.531E-2 3.751E-2
8.672E-2
 1 84
6 22q13.1 22q13.1 1.531E-2 1.531E-2 3.751E-2
9.185E-2
 1 89
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 16 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$ATF6 01 V$ATF6 01 9.352E-6 1.496E-4 5.059E-4 1.496E-4 3 97
2 V$CREB 02 V$CREB 02 8.077E-5 6.462E-4 2.185E-3 1.292E-3 3 199
3 GTGACGY V$E4F1 Q6 GTGACGY V$E4F1 Q6 1.212E-3 6.462E-3 2.185E-2 1.939E-2 3 497

12: Gene Family [Display Chart] 2 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 449 UDP-N-acetylglucosaminyltransferase subunits|OTU domain containing|Tudor domain containing genenames.org 2.198E-4 8.794E-4 1.832E-3 8.794E-4 1 2
2 894 Astacins genenames.org 6.595E-4 1.319E-3 2.748E-3 2.638E-3 1 6
3 669 OTU domain containing genenames.org 1.868E-3 2.491E-3 5.189E-3 7.472E-3 1 17
4 780 RNA binding motif containing|Tudor domain containing genenames.org 4.063E-3 4.063E-3 8.465E-3 1.625E-2 1 37

13: Coexpression [Display Chart] 6 input genes in category / 509 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18974375-TableS5b Human Lymphoma Chng09 174genes GeneSigDB 3.268E-6 1.542E-3 1.050E-2 1.663E-3 3 128
2 M4450 Genes down-regulated in comparison of memory IgG IgA B cells versus plasma cells from bone marrow and blood. MSigDB C7: Immunologic Signatures (v6.0) 1.193E-5 1.542E-3 1.050E-2 6.073E-3 3 197
3 M3253 Genes up-regulated in comparison of plasma cells versus memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.211E-5 1.542E-3 1.050E-2 6.166E-3 3 198
4 M4443 Genes down-regulated in comparison of naive B cells versus plasma cells from bone marrow and blood. MSigDB C7: Immunologic Signatures (v6.0) 1.211E-5 1.542E-3 1.050E-2 6.166E-3 3 198
5 M7488 Antigen processing and presentation genes up-regulated in JY cells (B lymphocytes) treated with TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.122E-4 1.142E-2
7.778E-2
5.710E-2
 2 64
6 M4552 Genes up-regulated in plasma cells compared with B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.668E-4 1.415E-2
9.639E-2
8.492E-2
 2 78
7 M8475 Up-regulated genes specific to esophageal adenocarcinoma (EAC) relative to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.013E-4 2.134E-2
1.453E-1
2.043E-1
 2 121
8 15833844-Table1S Human Esophagus Kimchi05 213genes GeneSigDB 8.082E-4 2.134E-2
1.453E-1
4.114E-1
 2 172
9 M1542 Genes up-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.364E-4 2.134E-2
1.453E-1
4.257E-1
 2 175
10 M6807 Genes up-regulated in B lymphocytes treated by anti-HEL and expressing BCR [GeneID=613] fusions with: IgM versus IgMG. MSigDB C7: Immunologic Signatures (v6.0) 9.440E-4 2.134E-2
1.453E-1
4.805E-1
 2 186
11 16449976-SuppTable2 Human Esophagus Wang06 245genes GeneSigDB 9.541E-4 2.134E-2
1.453E-1
4.856E-1
 2 187
12 M6819 Genes up-regulated in dendritic cells: untreated versus inflammatory cytokine cocktail. MSigDB C7: Immunologic Signatures (v6.0) 9.642E-4 2.134E-2
1.453E-1
4.908E-1
 2 188
13 M8502 Genes down-regulated in B16 melanoma at day 7 of adoptive transfer treatment: mock versus therapy. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.134E-2
1.453E-1
5.385E-1
 2 197
14 M3252 Genes down-regulated in comparison of Ig isotype switched memory B cells versus plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.134E-2
1.453E-1
5.439E-1
 2 198
15 M8414 Genes up-regulated in spleen CD8+ dendritic cells versus bone marrow monocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.134E-2
1.453E-1
5.439E-1
 2 198
16 M4441 Genes down-regulated in comparison of naive B cells versus blood plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.134E-2
1.453E-1
5.439E-1
 2 198
17 M5243 Genes up-regulated in comparison of macrophages exposed to L. major versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.134E-2
1.453E-1
5.494E-1
 2 199
18 M9127 Genes up-regulated in T reg: IKZF4 [GeneID=64375] versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
19 M5783 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 1 month later. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
20 M5201 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to 50 worm/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
21 M9314 Genes up-regulated in follicular B cells versus day 7 plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
22 M9944 Genes up-regulated in B lymphocytes treated by anti IgM for 24h: wildtype versus MAP3K7 [GeneID=6885] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
23 M5233 Genes up-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
24 M9831 Genes up-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4high. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
25 M5787 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 4 months later. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
26 M7028 Genes down-regulated in granulo-monocyte progenitors: wildtype versus IKZF1 [GeneID=10320] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.134E-2
1.453E-1
5.548E-1
 2 200
27 17894856-SuppList2 Human Breast Yu07 400genes GeneSigDB 1.709E-3 3.221E-2
2.194E-1
8.696E-1
 2 251
28 15897907-SuppTable5 Human Breast Farmer05 269genes basal apocrine luminal GeneSigDB 1.804E-3 3.279E-2
2.233E-1
9.182E-1
 2 258
29 M6510 Genes up-regulated in post-GC, BCL6 [GeneID=604] dependent B cell non-Hodgkin's lymphoma (B-NHL) vs MYC [GeneID=4609] driven pre-GC lymphoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.165E-3 3.800E-2
2.588E-1
1.000E0
 2 283
Show 24 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 385 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Mouse Cell Atlas Mouse Regional GI Enterocytes Goblet Goblet Subtype Goblet Ileum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Goblet Goblet Subtype Goblet Ileum Top 200 Genes Mouse Cell Atlas 2.405E-5 9.261E-3
6.049E-2
 9.261E-3 3 235
2 Mouse Cell Atlas Mouse Regional GI Enterocytes Goblet Goblet Top 200 Mouse Cell Atlas Mouse Regional GI Enterocytes Goblet Goblet Top 200 Mouse Cell Atlas 1.866E-4 3.593E-2
2.347E-1
7.185E-2
 3 468

15: Computational [Display Chart] 5 input genes in category / 17 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3370 MODULE 155 Genes in the cancer module 155. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.929E-5 5.459E-4 1.878E-3 1.008E-3 2 25
2 M19205 MODULE 245 Genes in the cancer module 245. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.422E-5 5.459E-4 1.878E-3 1.092E-3 2 26

16: MicroRNA [Display Chart] 6 input genes in category / 167 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 4.104E-6 6.854E-4 3.906E-3 6.854E-4 3 429
2 hsa-miR-4786-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.006E-4 1.176E-2
6.703E-2
 3.351E-2 2 266
3 hsa-miR-142-3p.1:TargetScan hsa-miR-142-3p.1 TargetScan 2.113E-4 1.176E-2
6.703E-2
 3.529E-2 2 273
4 hsa-miR-301a-3p:Functional MTI Functional MTI miRTarbase 4.409E-4 1.841E-2
1.049E-1
7.363E-2
 2 395
5 hsa-miR-941:PITA hsa-miR-941:PITA TOP PITA 1.494E-3 2.877E-2
1.639E-1
2.495E-1
 1 18
6 hsa-miR-548ad-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.743E-3 2.877E-2
1.639E-1
2.911E-1
 1 21
7 hsa-miR-4999-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.069E-3 2.877E-2
1.639E-1
5.126E-1
 1 37
8 hsa-miR-150-3p:Functional MTI Functional MTI miRTarbase 3.318E-3 2.877E-2
1.639E-1
5.541E-1
 1 40
9 hsa-miR-5579-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.566E-3 2.877E-2
1.639E-1
5.956E-1
 1 43
10 hsa-miR-1227-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 2.877E-2
1.639E-1
6.647E-1
 1 48
11 hsa-miR-550a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 2.877E-2
1.639E-1
6.785E-1
 1 49
12 hsa-miR-200c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.877E-2
1.639E-1
6.923E-1
 1 50
13 hsa-miR-3140-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.877E-2
1.639E-1
7.200E-1
 1 52
14 hsa-miR-600:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.877E-2
1.639E-1
7.200E-1
 1 52
15 hsa-miR-4427:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.877E-2
1.639E-1
7.338E-1
 1 53
16 hsa-miR-8069:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 2.877E-2
1.639E-1
8.029E-1
 1 58
17 hsa-miR-34c-3p:Functional MTI Functional MTI miRTarbase 4.808E-3 2.877E-2
1.639E-1
8.029E-1
 1 58
18 hsa-miR-26a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.890E-3 2.877E-2
1.639E-1
8.167E-1
 1 59
19 hsa-miR-4501:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 2.877E-2
1.639E-1
8.443E-1
 1 61
20 hsa-miR-6762-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 2.877E-2
1.639E-1
9.272E-1
 1 67
21 hsa-miR-6845-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 2.877E-2
1.639E-1
9.272E-1
 1 67
22 hsa-miR-128-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 2.877E-2
1.639E-1
9.410E-1
 1 68
23 hsa-miR-432-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.877E-2
1.639E-1
9.548E-1
 1 69
24 hsa-miR-520f-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.877E-2
1.639E-1
9.548E-1
 1 69
25 hsa-miR-513b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.877E-2
1.639E-1
9.548E-1
 1 69
26 hsa-miR-4744:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.877E-2
1.639E-1
9.548E-1
 1 69
27 hsa-miR-26a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.883E-3 2.877E-2
1.639E-1
9.824E-1
 1 71
28 hsa-miR-6802-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 2.877E-2
1.639E-1
9.962E-1
 1 72
29 hsa-miR-128-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 2.877E-2
1.639E-1
9.962E-1
 1 72
30 hsa-miR-6884-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 2.877E-2
1.639E-1
1.000E0
 1 73
31 hsa-miR-4778-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.296E-3 2.877E-2
1.639E-1
1.000E0
 1 76
32 hsa-miR-4260:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 2.877E-2
1.639E-1
1.000E0
 1 77
33 hsa-miR-1245b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.544E-3 2.877E-2
1.639E-1
1.000E0
 1 79
34 hsa-miR-3130-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 2.877E-2
1.639E-1
1.000E0
 1 83
35 hsa-miR-3182:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 2.877E-2
1.639E-1
1.000E0
 1 84
36 hsa-miR-4802-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 2.877E-2
1.639E-1
1.000E0
 1 85
37 hsa-miR-1183:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 2.877E-2
1.639E-1
1.000E0
 1 85
38 hsa-miR-493-3p:Functional MTI Functional MTI miRTarbase 7.287E-3 2.877E-2
1.639E-1
1.000E0
 1 88
39 hsa-miR-5585-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.369E-3 2.877E-2
1.639E-1
1.000E0
 1 89
40 hsa-miR-452-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 2.877E-2
1.639E-1
1.000E0
 1 91
41 hsa-miR-548m:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 2.877E-2
1.639E-1
1.000E0
 1 95
42 hsa-miR-20b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 2.877E-2
1.639E-1
1.000E0
 1 95
43 hsa-miR-1193:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 2.877E-2
1.639E-1
1.000E0
 1 98
44 hsa-miR-3607-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.195E-3 2.877E-2
1.639E-1
1.000E0
 1 99
45 hsa-miR-2114-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.195E-3 2.877E-2
1.639E-1
1.000E0
 1 99
46 hsa-miR-4308:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.277E-3 2.877E-2
1.639E-1
1.000E0
 1 100
47 hsa-miR-5683:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.277E-3 2.877E-2
1.639E-1
1.000E0
 1 100
48 hsa-miR-1205:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 2.877E-2
1.639E-1
1.000E0
 1 101
49 hsa-miR-3158-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.442E-3 2.877E-2
1.639E-1
1.000E0
 1 102
50 hsa-miR-5588-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.772E-3 2.899E-2
1.652E-1
1.000E0
 1 106
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 824 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000131113 Hdel sequence Stitch 7.799E-8 6.427E-5 4.686E-4 6.427E-5 3 37
2 CID000123910 Kdel Sequence Stitch 3.787E-7 1.560E-4 1.138E-3 3.120E-4 3 62
3 CID005287758 AC1NRA8N Stitch 1.112E-5 3.056E-3 2.228E-2 9.167E-3 3 190
4 CID005282055 C12063 Stitch 1.262E-4 2.599E-2
1.895E-1
1.040E-1
 3 429
5 CID000010825 caronamide Stitch 2.627E-4 3.608E-2
2.631E-1
2.165E-1
 1 1
6 CID000102764 N2 750 Stitch 2.627E-4 3.608E-2
2.631E-1
2.165E-1
 1 1
7 ctd:C010327 salinomycin CTD 9.580E-4 4.561E-2
3.326E-1
7.894E-1
 2 185
8 1647 DN 2-propylpentanoic acid; Down 200; 50uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.031E-3 4.561E-2
3.326E-1
8.497E-1
 2 192
9 DB03963 S-(Dimethylarsenic)Cysteine Drug Bank 1.050E-3 4.561E-2
3.326E-1
8.655E-1
 1 4
10 1724 DN Imipenem [74431-23-5]; Down 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.053E-3 4.561E-2
3.326E-1
8.674E-1
 2 194
11 1581 DN Chlorthalidone [77-36-1]; Down 200; 11.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.053E-3 4.561E-2
3.326E-1
8.674E-1
 2 194
12 5327 DN Benfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.063E-3 4.561E-2
3.326E-1
8.763E-1
 2 195
13 1558 DN Cinnarizine [298-57-7]; Down 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.074E-3 4.561E-2
3.326E-1
8.852E-1
 2 196
14 2036 UP Baclofen (R,S) [1134-47-0]; Up 200; 18.8uM; HL60; HG-U133A Broad Institute CMAP Up 1.074E-3 4.561E-2
3.326E-1
8.852E-1
 2 196
15 6550 DN PHA-00767505E [723337-45-9]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.085E-3 4.561E-2
3.326E-1
8.942E-1
 2 197
16 5429 DN Tribenoside [10310-32-4]; Down 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.085E-3 4.561E-2
3.326E-1
8.942E-1
 2 197
17 1777 DN Acetopromazine maleate salt [3598-37-6]; Down 200; 9uM; HL60; HG-U133A Broad Institute CMAP Down 1.085E-3 4.561E-2
3.326E-1
8.942E-1
 2 197
18 642 DN 6-thioguanine; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 1.096E-3 4.561E-2
3.326E-1
9.032E-1
 2 198
19 2369 DN Dantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.096E-3 4.561E-2
3.326E-1
9.032E-1
 2 198
20 6632 DN SR-95639A [115767-94-7]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.107E-3 4.561E-2
3.326E-1
9.123E-1
 2 199
Show 15 more annotations

18: Disease [Display Chart] 5 input genes in category / 10 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:CN160488 Congenital disorder of glycosylation type 1s Clinical Variations 3.085E-4 3.085E-3 9.037E-3 3.085E-3 1 1
2 C3550904 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 36 DisGeNET Curated 2.158E-3 8.221E-3 2.408E-2 2.158E-2 1 7
3 cv:C0282577 Carbohydrate-deficient glycoprotein syndrome Clinical Variations 2.466E-3 8.221E-3 2.408E-2 2.466E-2 1 8
4 C0013364 Dysautonomia, Familial DisGeNET Curated 6.464E-3 1.616E-2 4.733E-2
6.464E-2
 1 21
5 C0678213 Complete hydatidiform mole DisGeNET Curated 9.836E-3 1.894E-2
5.548E-2
9.836E-2
 1 32
6 C3887898 Infantile Spasm DisGeNET Curated 1.137E-2 1.894E-2
5.548E-2
1.137E-1
 1 37
7 C0543888 Epileptic encephalopathy DisGeNET Curated 1.747E-2 2.183E-2
6.395E-2
1.747E-1
 1 57
8 C0037769 West Syndrome DisGeNET Curated 1.747E-2 2.183E-2
6.395E-2
1.747E-1
 1 57
Show 3 more annotations