Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc56_13, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 12 input genes in category / 19 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030742 GTP-dependent protein binding 8.694E-5 1.652E-3 5.861E-3 1.652E-3 2 22
2 GO:0000149 SNARE binding 3.222E-3 3.061E-2
1.086E-1
6.122E-2
 2 134

2: GO: Biological Process [Display Chart] 13 input genes in category / 283 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043473 pigmentation 6.179E-27 1.749E-24 1.088E-23 1.749E-24 12 104
2 GO:0099514 synaptic vesicle cytoskeletal transport 4.614E-23 3.265E-21 2.032E-20 1.306E-20 8 16
3 GO:0099517 synaptic vesicle transport along microtubule 4.614E-23 3.265E-21 2.032E-20 1.306E-20 8 16
4 GO:0048490 anterograde synaptic vesicle transport 4.614E-23 3.265E-21 2.032E-20 1.306E-20 8 16
5 GO:0032438 melanosome organization 2.632E-21 1.490E-19 9.272E-19 7.448E-19 8 24
6 GO:0048753 pigment granule organization 3.869E-21 1.825E-19 1.136E-18 1.095E-18 8 25
7 GO:0008089 anterograde axonal transport 7.939E-21 3.210E-19 1.998E-18 2.247E-18 8 27
8 GO:0047496 vesicle transport along microtubule 1.744E-19 6.170E-18 3.840E-17 4.936E-17 8 38
9 GO:0008088 axo-dendritic transport 4.206E-19 1.322E-17 8.231E-17 1.190E-16 8 42
10 GO:0099518 vesicle cytoskeletal trafficking 5.166E-19 1.462E-17 9.099E-17 1.462E-16 8 43
11 GO:0033059 cellular pigmentation 2.264E-18 5.825E-17 3.625E-16 6.407E-16 8 51
12 GO:0072384 organelle transport along microtubule 1.789E-17 4.218E-16 2.625E-15 5.062E-15 8 65
13 GO:0010970 transport along microtubule 1.793E-15 3.902E-14 2.429E-13 5.073E-13 8 113
14 GO:0048489 synaptic vesicle transport 6.830E-15 1.285E-13 7.995E-13 1.933E-12 8 133
15 GO:0097480 establishment of synaptic vesicle localization 6.830E-15 1.285E-13 7.995E-13 1.933E-12 8 133
16 GO:0030705 cytoskeleton-dependent intracellular transport 7.262E-15 1.285E-13 7.995E-13 2.055E-12 8 134
17 GO:0097479 synaptic vesicle localization 1.101E-14 1.833E-13 1.141E-12 3.117E-12 8 141
18 GO:0007018 microtubule-based movement 6.957E-13 1.094E-11 6.808E-11 1.969E-10 8 235
19 GO:0051650 establishment of vesicle localization 1.221E-12 1.819E-11 1.132E-10 3.457E-10 8 252
20 GO:0051648 vesicle localization 1.945E-12 2.752E-11 1.713E-10 5.504E-10 8 267
21 GO:0016050 vesicle organization 1.825E-11 2.459E-10 1.531E-9 5.165E-9 8 353
22 GO:0051656 establishment of organelle localization 1.020E-10 1.312E-9 8.168E-9 2.887E-8 8 438
23 GO:0007596 blood coagulation 1.566E-9 1.927E-8 1.199E-7 4.432E-7 7 363
24 GO:0007599 hemostasis 1.722E-9 1.950E-8 1.214E-7 4.874E-7 7 368
25 GO:0050817 coagulation 1.722E-9 1.950E-8 1.214E-7 4.874E-7 7 368
26 GO:0050931 pigment cell differentiation 1.040E-8 1.132E-7 7.044E-7 2.942E-6 4 38
27 GO:0060155 platelet dense granule organization 1.485E-8 1.557E-7 9.689E-7 4.203E-6 3 8
28 GO:0007034 vacuolar transport 2.034E-8 2.056E-7 1.280E-6 5.758E-6 6 288
29 GO:0048087 positive regulation of developmental pigmentation 2.227E-8 2.173E-7 1.353E-6 6.302E-6 3 9
30 GO:0048066 developmental pigmentation 4.427E-8 4.176E-7 2.599E-6 1.253E-5 4 54
31 GO:0048070 regulation of developmental pigmentation 1.797E-7 1.640E-6 1.021E-5 5.085E-5 3 17
32 GO:0016197 endosomal transport 5.882E-7 5.202E-6 3.238E-5 1.665E-4 5 259
33 GO:0030318 melanocyte differentiation 8.618E-7 7.391E-6 4.600E-5 2.439E-4 3 28
34 GO:0033363 secretory granule organization 1.570E-6 1.307E-5 8.136E-5 4.444E-4 3 34
35 GO:0050942 positive regulation of pigment cell differentiation 9.428E-6 7.623E-5 4.745E-4 2.668E-3 2 7
36 GO:0050932 regulation of pigment cell differentiation 1.615E-5 1.270E-4 7.902E-4 4.570E-3 2 9
37 GO:0048757 pigment granule maturation 2.018E-5 1.464E-4 9.114E-4 5.711E-3 2 10
38 GO:0043485 endosome to pigment granule transport 2.018E-5 1.464E-4 9.114E-4 5.711E-3 2 10
39 GO:0035646 endosome to melanosome transport 2.018E-5 1.464E-4 9.114E-4 5.711E-3 2 10
40 GO:0043476 pigment accumulation 2.957E-5 2.031E-4 1.264E-3 8.369E-3 2 12
41 GO:0043482 cellular pigment accumulation 2.957E-5 2.031E-4 1.264E-3 8.369E-3 2 12
42 GO:0060563 neuroepithelial cell differentiation 3.014E-5 2.031E-4 1.264E-3 8.530E-3 3 90
43 GO:0032402 melanosome transport 1.129E-4 7.428E-4 4.624E-3 3.194E-2 2 23
44 GO:0051904 pigment granule transport 1.231E-4 7.740E-4 4.818E-3 3.483E-2 2 24
45 GO:0032401 establishment of melanosome localization 1.231E-4 7.740E-4 4.818E-3 3.483E-2 2 24
46 GO:0051905 establishment of pigment granule localization 1.337E-4 8.227E-4 5.121E-3 3.785E-2 2 25
47 GO:0002065 columnar/cuboidal epithelial cell differentiation 1.464E-4 8.815E-4 5.487E-3 4.143E-2 3 153
48 GO:0032400 melanosome localization 1.563E-4 9.218E-4 5.738E-3 4.425E-2 2 27
49 GO:0051875 pigment granule localization 1.683E-4 9.720E-4 6.050E-3 4.763E-2 2 28
50 GO:0099643 signal release from synapse 1.765E-4 9.795E-4 6.097E-3 4.995E-2 3 163
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 67 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031082 BLOC complex 9.118E-33 6.109E-31 2.926E-30 6.109E-31 11 21
2 GO:0044445 cytosolic part 6.038E-20 1.810E-18 8.671E-18 4.045E-18 11 235
3 GO:1904115 axon cytoplasm 8.966E-20 1.810E-18 8.671E-18 6.007E-18 8 36
4 GO:0031083 BLOC-1 complex 1.081E-19 1.810E-18 8.671E-18 7.242E-18 7 16
5 GO:0032838 plasma membrane bounded cell projection cytoplasm 1.140E-17 1.528E-16 7.318E-16 7.640E-16 8 63
6 GO:0033267 axon part 5.228E-12 5.838E-11 2.796E-10 3.503E-10 8 309
7 GO:0099568 cytoplasmic region 7.835E-12 7.500E-11 3.592E-10 5.250E-10 8 325
8 GO:0031084 BLOC-2 complex 2.478E-10 2.076E-9 9.941E-9 1.660E-8 3 3
9 GO:0030133 transport vesicle 3.201E-6 2.383E-5 1.141E-4 2.145E-4 5 374
10 GO:0030672 synaptic vesicle membrane 7.682E-4 4.679E-3 2.241E-2
5.147E-2
 2 61
11 GO:0099501 exocytic vesicle membrane 7.682E-4 4.679E-3 2.241E-2
5.147E-2
 2 61
12 GO:0031085 BLOC-3 complex 1.364E-3 7.322E-3 3.507E-2
9.136E-2
 1 2
13 GO:0098793 presynapse 1.421E-3 7.322E-3 3.507E-2
9.519E-2
 3 341
14 GO:0042470 melanosome 2.253E-3 1.007E-2 4.821E-2
1.510E-1
 2 105
15 GO:0048770 pigment granule 2.253E-3 1.007E-2 4.821E-2
1.510E-1
 2 105
16 GO:0008021 synaptic vesicle 4.893E-3 1.977E-2
9.467E-2
3.278E-1
 2 156
17 GO:0030658 transport vesicle membrane 5.016E-3 1.977E-2
9.467E-2
3.360E-1
 2 158
18 GO:0070382 exocytic vesicle 5.915E-3 2.051E-2
9.824E-2
3.963E-1
 2 172
19 GO:0033162 melanosome membrane 6.123E-3 2.051E-2
9.824E-2
4.102E-1
 1 9
20 GO:0045009 chitosome 6.123E-3 2.051E-2
9.824E-2
4.102E-1
 1 9
21 GO:0030123 AP-3 adaptor complex 8.156E-3 2.602E-2
1.246E-1
5.464E-1
 1 12
22 GO:0005802 trans-Golgi network 9.183E-3 2.797E-2
1.339E-1
6.153E-1
 2 216
23 GO:0042827 platelet dense granule 1.356E-2 3.785E-2
1.813E-1
9.085E-1
 1 20
24 GO:0000930 gamma-tubulin complex 1.356E-2 3.785E-2
1.813E-1
9.085E-1
 1 20
25 GO:0098852 lytic vacuole membrane 1.477E-2 3.806E-2
1.823E-1
9.894E-1
 2 277
26 GO:0005765 lysosomal membrane 1.477E-2 3.806E-2
1.823E-1
9.894E-1
 2 277
27 GO:0005769 early endosome 1.872E-2 4.645E-2
2.224E-1
1.000E0
 2 314
28 GO:0098791 Golgi subcompartment 2.008E-2 4.684E-2
2.243E-1
1.000E0
 2 326
29 GO:0030131 clathrin adaptor complex 2.027E-2 4.684E-2
2.243E-1
1.000E0
 1 30
30 GO:0031984 organelle subcompartment 2.185E-2 4.880E-2
2.337E-1
1.000E0
 2 341
Show 25 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 87 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011883 Abnormal platelet granules 2.012E-8 1.751E-6 8.839E-6 1.751E-6 3 5
2 HP:0007513 Generalized hypopigmentation 2.252E-7 2.925E-6 1.477E-5 1.959E-5 6 270
3 HP:0001107 Ocular albinism 2.252E-7 2.925E-6 1.477E-5 1.959E-5 6 270
4 HP:0001022 Albinism 2.252E-7 2.925E-6 1.477E-5 1.959E-5 6 270
5 HP:0001010 Hypopigmentation of the skin 2.252E-7 2.925E-6 1.477E-5 1.959E-5 6 270
6 HP:0005599 Hypopigmentation of hair 2.252E-7 2.925E-6 1.477E-5 1.959E-5 6 270
7 HP:0009887 Abnormality of hair pigmentation 2.354E-7 2.925E-6 1.477E-5 2.048E-5 6 272
8 HP:0007730 Iris hypopigmentation 4.152E-7 4.516E-6 2.280E-5 3.612E-5 6 299
9 HP:0008034 Abnormal iris pigmentation 6.841E-7 6.613E-6 3.339E-5 5.952E-5 6 325
10 HP:0000980 Pallor 1.971E-6 1.715E-5 8.660E-5 1.715E-4 6 388
11 HP:0011875 Abnormal platelet morphology 5.804E-6 4.590E-5 2.318E-4 5.050E-4 3 27
12 HP:0030402 Abnormal platelet aggregation 1.440E-3 9.183E-3 4.636E-2
1.252E-1
 2 40
13 HP:0003540 Impaired platelet aggregation 1.440E-3 9.183E-3 4.636E-2
1.252E-1
 2 40
14 HP:0007384 Aberrant melanosome maturation 1.487E-3 9.183E-3 4.636E-2
1.294E-1
 1 1
15 HP:0002206 Pulmonary fibrosis 1.583E-3 9.183E-3 4.636E-2
1.377E-1
 3 175
16 HP:0011869 Abnormal platelet function 2.910E-3 1.582E-2
7.989E-2
2.532E-1
 2 57
17 HP:0004866 Impaired ADP-induced platelet aggregation 4.456E-3 2.280E-2
1.151E-1
3.877E-1
 1 3
18 HP:0007603 Freckles in sun-exposed areas 7.417E-3 3.585E-2
1.810E-1
6.453E-1
 1 5
19 HP:0011125 Abnormality of dermal melanosomes 1.037E-2 4.741E-2
2.394E-1
9.022E-1
 1 7
20 HP:0000421 Epistaxis 1.090E-2 4.741E-2
2.394E-1
9.482E-1
 2 112
Show 15 more annotations

5: Mouse Phenotype [Display Chart] 13 input genes in category / 293 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020432 decreased platelet dense granule number 2.525E-21 2.638E-19 1.651E-18 7.399E-19 8 15
2 MP:0004722 abnormal platelet dense granule number 2.525E-21 2.638E-19 1.651E-18 7.399E-19 8 15
3 MP:0004721 abnormal platelet dense granule morphology 2.701E-21 2.638E-19 1.651E-18 7.915E-19 9 30
4 MP:0001324 abnormal eye pigmentation 1.119E-18 6.806E-17 4.260E-16 3.278E-16 11 168
5 MP:0009448 decreased platelet ATP level 1.161E-18 6.806E-17 4.260E-16 3.403E-16 7 13
6 MP:0009389 abnormal extracutaneous pigmentation 1.664E-18 8.124E-17 5.085E-16 4.874E-16 11 174
7 MP:0009447 abnormal platelet ATP level 4.351E-18 1.821E-16 1.140E-15 1.275E-15 7 15
8 MP:0000371 diluted coat color 2.647E-17 9.695E-16 6.068E-15 7.756E-15 9 76
9 MP:0005606 increased bleeding time 1.449E-16 4.716E-15 2.952E-14 4.245E-14 9 91
10 MP:0005172 decreased eye pigmentation 4.423E-16 1.296E-14 8.111E-14 1.296E-13 7 26
11 MP:0005075 abnormal melanosome morphology 1.939E-15 5.164E-14 3.232E-13 5.680E-13 8 65
12 MP:0005408 hypopigmentation 4.583E-15 1.046E-13 6.546E-13 1.343E-12 8 72
13 MP:0004723 abnormal platelet serotonin level 4.997E-15 1.046E-13 6.546E-13 1.464E-12 6 15
14 MP:0004725 decreased platelet serotonin level 4.997E-15 1.046E-13 6.546E-13 1.464E-12 6 15
15 MP:0005100 abnormal choroid pigmentation 3.859E-14 7.537E-13 4.718E-12 1.131E-11 6 20
16 MP:0002877 abnormal melanocyte morphology 1.053E-13 1.927E-12 1.206E-11 3.084E-11 8 105
17 MP:0001186 pigmentation phenotype 1.599E-13 2.755E-12 1.725E-11 4.684E-11 11 487
18 MP:0005201 abnormal retinal pigment epithelium morphology 8.253E-13 1.343E-11 8.408E-11 2.418E-10 8 135
19 MP:0009549 decreased platelet aggregation 8.739E-13 1.348E-11 8.435E-11 2.560E-10 7 71
20 MP:0002075 abnormal coat/hair pigmentation 4.016E-12 5.883E-11 3.682E-10 1.177E-9 9 277
21 MP:0002551 abnormal blood coagulation 4.571E-12 6.378E-11 3.992E-10 1.339E-9 9 281
22 MP:0009676 abnormal hemostasis 4.873E-12 6.491E-11 4.063E-10 1.428E-9 9 283
23 MP:0009548 abnormal platelet aggregation 5.695E-12 7.255E-11 4.541E-10 1.669E-9 7 92
24 MP:0010070 decreased serotonin level 5.989E-12 7.311E-11 4.576E-10 1.755E-9 6 43
25 MP:0006298 abnormal platelet activation 8.330E-12 9.763E-11 6.111E-10 2.441E-9 7 97
26 MP:0003172 abnormal lysosome physiology 1.202E-11 1.354E-10 8.478E-10 3.522E-9 6 48
27 MP:0005098 abnormal optic choroid morphology 3.165E-11 3.435E-10 2.150E-9 9.275E-9 6 56
28 MP:0005464 abnormal platelet physiology 5.706E-11 5.971E-10 3.737E-9 1.672E-8 7 127
29 MP:0004720 abnormal platelet morphology 1.045E-10 1.056E-9 6.608E-9 3.062E-8 9 398
30 MP:0005322 abnormal serotonin level 1.787E-10 1.717E-9 1.075E-8 5.236E-8 6 74
31 MP:0009557 decreased platelet ADP level 1.875E-10 1.717E-9 1.075E-8 5.494E-8 4 9
32 MP:0009556 abnormal platelet ADP level 1.875E-10 1.717E-9 1.075E-8 5.494E-8 4 9
33 MP:0008480 absent eye pigmentation 4.904E-10 4.354E-9 2.725E-8 1.437E-7 4 11
34 MP:0009446 abnormal platelet dense granule physiology 2.023E-9 1.743E-8 1.091E-7 5.927E-7 4 15
35 MP:0011279 decreased ear pigmentation 2.695E-9 2.256E-8 1.412E-7 7.897E-7 4 16
36 MP:0003727 abnormal retinal layer morphology 7.523E-9 6.123E-8 3.832E-7 2.204E-6 8 421
37 MP:0005197 abnormal uvea morphology 4.490E-8 3.556E-7 2.225E-6 1.316E-5 6 184
38 MP:0000015 abnormal ear pigmentation 4.611E-8 3.556E-7 2.225E-6 1.351E-5 4 31
39 MP:0003173 decreased lysosomal enzyme secretion 5.395E-8 4.053E-7 2.537E-6 1.581E-5 3 7
40 MP:0030530 abnormal outer ear skin morphology 5.989E-8 4.387E-7 2.746E-6 1.755E-5 4 33
41 MP:0002204 abnormal neurotransmitter level 1.488E-7 1.063E-6 6.655E-6 4.359E-5 6 225
42 MP:0030529 abnormal head skin morphology 2.162E-7 1.509E-6 9.442E-6 6.336E-5 4 45
43 MP:0005103 abnormal retinal pigmentation 7.004E-7 4.772E-6 2.987E-5 2.052E-4 4 60
44 MP:0005102 abnormal iris pigmentation 1.741E-6 1.159E-5 7.256E-5 5.101E-4 3 20
45 MP:0002095 abnormal skin pigmentation 9.229E-6 6.009E-5 3.761E-4 2.704E-3 4 114
46 MP:0011239 abnormal skin coloration 1.208E-5 7.694E-5 4.816E-4 3.539E-3 4 122
47 MP:0002177 abnormal outer ear morphology 2.523E-5 1.548E-4 9.686E-4 7.394E-3 4 147
48 MP:0005341 decreased susceptibility to atherosclerosis 2.588E-5 1.548E-4 9.686E-4 7.583E-3 3 48
49 MP:0005191 head tilt 2.588E-5 1.548E-4 9.686E-4 7.583E-3 3 48
50 MP:0008546 abnormal vesicle-mediated transport 3.109E-5 1.822E-4 1.140E-3 9.110E-3 3 51
Show 45 more annotations

6: Domain [Display Chart] 13 input genes in category / 44 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF14712 Snapin Pallidin Pfam 4.445E-7 9.778E-6 4.276E-5 1.956E-5 2 2
2 IPR028119 Snapin/Pallidin/Snn1 InterPro 4.445E-7 9.778E-6 4.276E-5 1.956E-5 2 2
3 IPR029437 HPS3 N InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
4 PF14763 HPS3 C Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
5 IPR029438 HPS3 C InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
6 PF15702 HPS6 Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
7 IPR017246 Snapin InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
8 PF14762 HPS3 Mid Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
9 PF14761 HPS3 N Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
10 IPR029394 AP3B1 Ser InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
11 PF14942 Muted Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
12 IPR009395 BLOC1S1 InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
13 PF14797 SEEEED Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
14 IPR019269 BLOC1 su2 InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
15 IPR028167 HPS3 central dom InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
16 PF10046 BLOC1 2 Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
17 PF06320 GCN5L1 Pfam 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
18 IPR017216 HPS3 InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
19 IPR017242 BLOC-1 pallidin InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
20 IPR026091 HPS4 InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
21 IPR017243 Bloc1s5 InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
22 IPR017218 BLOC-2 complex Hps6 subunit InterPro 6.939E-4 1.388E-3 6.068E-3 3.053E-2 1 1
23 IPR026740 AP3 beta InterPro 1.387E-3 2.261E-3 9.886E-3
6.104E-2
 1 2
24 SM01355 AP3B1 C SMART 1.387E-3 2.261E-3 9.886E-3
6.104E-2
 1 2
25 IPR029390 AP3B C InterPro 1.387E-3 2.261E-3 9.886E-3
6.104E-2
 1 2
26 PF14796 AP3B1 C Pfam 1.387E-3 2.261E-3 9.886E-3
6.104E-2
 1 2
27 IPR024857 Cappuccino InterPro 1.387E-3 2.261E-3 9.886E-3
6.104E-2
 1 2
28 PF04440 Dysbindin Pfam 2.080E-3 3.156E-3 1.380E-2
9.153E-2
 1 3
29 IPR007531 Dysbindin InterPro 2.080E-3 3.156E-3 1.380E-2
9.153E-2
 1 3
30 IPR015151 B-adaptin app sub C InterPro 2.773E-3 3.936E-3 1.721E-2
1.220E-1
 1 4
31 SM01020 B2-adapt-app C SMART 2.773E-3 3.936E-3 1.721E-2
1.220E-1
 1 4
32 IPR026739 AP beta InterPro 3.465E-3 4.764E-3 2.083E-2
1.525E-1
 1 5
33 PF01602 Adaptin N Pfam 1.036E-2 1.341E-2
5.864E-2
4.559E-1
 1 15
34 IPR002553 Clathrin/coatomer adapt-like N InterPro 1.036E-2 1.341E-2
5.864E-2
4.559E-1
 1 15
Show 29 more annotations

7: Pathway [Display Chart] 8 input genes in category / 14 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269882 Golgi Associated Vesicle Biogenesis BioSystems: REACTOME 1.953E-13 2.734E-12 8.891E-12 2.734E-12 6 57
2 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 9.141E-13 4.266E-12 1.387E-11 1.280E-11 6 73
3 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 9.141E-13 4.266E-12 1.387E-11 1.280E-11 6 73
4 1457806 RAB GEFs exchange GTP for GDP on RABs BioSystems: REACTOME 1.438E-3 5.032E-3 1.636E-2 2.013E-2 2 91
5 M8179 Rab GTPases Mark Targets In The Endocytotic Machinery MSigDB C2 BIOCARTA (v6.0) 7.687E-3 2.152E-2
6.999E-2
1.076E-1
 1 12

8: Pubmed [Display Chart] 13 input genes in category / 710 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21998198 The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Pubmed 5.013E-25 1.382E-22 9.871E-22 3.559E-22 8 18
2 15102850 Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). Pubmed 5.839E-25 1.382E-22 9.871E-22 4.146E-22 7 8
3 22203680 Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1). Pubmed 5.839E-25 1.382E-22 9.871E-22 4.146E-22 7 8
4 12445206 Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development. Pubmed 8.756E-24 1.243E-21 8.881E-21 6.217E-21 7 10
5 20301464 Hermansky-Pudlak Syndrome Pubmed 8.756E-24 1.243E-21 8.881E-21 6.217E-21 7 10
6 9714600 The AP-3 complex: a coat of many colours. Pubmed 6.696E-23 7.923E-21 5.660E-20 4.754E-20 8 30
7 19546860 The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. Pubmed 2.320E-21 2.353E-19 1.681E-18 1.647E-18 7 18
8 15265785 Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex. Pubmed 1.115E-20 9.893E-19 7.066E-18 7.914E-18 6 8
9 10193444 Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome. Pubmed 3.343E-20 2.638E-18 1.884E-17 2.374E-17 6 9
10 19010779 Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells. Pubmed 8.357E-20 5.934E-18 4.239E-17 5.934E-17 6 10
11 6696991 Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Pubmed 1.990E-18 1.285E-16 9.176E-16 1.413E-15 6 15
12 12576321 Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). Pubmed 3.990E-17 2.179E-15 1.557E-14 2.833E-14 5 7
13 18629000 Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis. Pubmed 3.990E-17 2.179E-15 1.557E-14 2.833E-14 5 7
14 12191018 Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. Pubmed 1.064E-16 5.036E-15 3.597E-14 7.554E-14 5 8
15 12923531 Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Pubmed 1.064E-16 5.036E-15 3.597E-14 7.554E-14 5 8
16 21045126 Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Pubmed 5.698E-15 2.529E-13 1.806E-12 4.046E-12 5 15
17 3516713 Progenitor cell defect correctable by bone marrow transplantation in five independent mouse models of platelet storage pool deficiency. Pubmed 4.032E-14 1.590E-12 1.136E-11 2.863E-11 4 5
18 22554196 The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles. Pubmed 4.032E-14 1.590E-12 1.136E-11 2.863E-11 4 5
19 16760431 BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Pubmed 1.209E-13 4.293E-12 3.067E-11 8.587E-11 4 6
20 22423091 Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1. Pubmed 1.209E-13 4.293E-12 3.067E-11 8.587E-11 4 6
21 15702992 Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV. Pubmed 5.642E-13 1.907E-11 1.363E-10 4.006E-10 4 8
22 2379821 Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Pubmed 1.099E-11 3.546E-10 2.533E-9 7.801E-9 4 15
23 14718540 The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2). Pubmed 3.080E-11 8.513E-10 6.081E-9 2.187E-8 3 3
24 17618940 Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Pubmed 3.080E-11 8.513E-10 6.081E-9 2.187E-8 3 3
25 15030569 Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6. Pubmed 3.080E-11 8.513E-10 6.081E-9 2.187E-8 3 3
26 27719760 BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. Pubmed 3.117E-11 8.513E-10 6.081E-9 2.213E-8 4 19
27 25189619 HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
28 17365864 Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
29 22611153 SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
30 25477496 Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
31 21392365 Functional interactions between OCA2 and the protein complexes BLOC-1, BLOC-2, and AP-3 inferred from epistatic analyses of mouse coat pigmentation. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
32 12847290 Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
33 25673877 Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells. Pubmed 1.232E-10 2.650E-9 1.893E-8 8.746E-8 3 4
34 2369371 Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function. Pubmed 3.079E-10 6.073E-9 4.338E-8 2.186E-7 3 5
35 23364476 Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism. Pubmed 3.079E-10 6.073E-9 4.338E-8 2.186E-7 3 5
36 20089890 Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus. Pubmed 3.079E-10 6.073E-9 4.338E-8 2.186E-7 3 5
37 17182842 BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Pubmed 6.157E-10 1.150E-8 8.218E-8 4.372E-7 3 6
38 22984402 Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. Pubmed 6.157E-10 1.150E-8 8.218E-8 4.372E-7 3 6
39 11252894 Three ways to make a vesicle. Pubmed 1.087E-9 1.978E-8 1.413E-7 7.716E-7 4 44
40 25898167 BORC, a multisubunit complex that regulates lysosome positioning. Pubmed 8.793E-9 1.561E-7 1.115E-6 6.243E-6 3 13
41 11031247 Secretory protein trafficking and organelle dynamics in living cells. Pubmed 1.608E-8 2.785E-7 1.990E-6 1.142E-5 4 85
42 26108535 Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting. Pubmed 1.069E-7 1.687E-6 1.205E-5 7.593E-5 2 2
43 16980328 Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Pubmed 1.069E-7 1.687E-6 1.205E-5 7.593E-5 2 2
44 23563589 An association study of the Hermansky-Pudlak syndrome type 4 gene in schizophrenic patients. Pubmed 1.069E-7 1.687E-6 1.205E-5 7.593E-5 2 2
45 28576874 BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. Pubmed 1.069E-7 1.687E-6 1.205E-5 7.593E-5 2 2
46 21833017 Clinical, molecular, and cellular features of non-Puerto Rican Hermansky-Pudlak syndrome patients of Hispanic descent. Pubmed 3.208E-7 4.380E-6 3.129E-5 2.278E-4 2 3
47 22203954 Targeting protein-trafficking pathways alters melanoma treatment sensitivity. Pubmed 3.208E-7 4.380E-6 3.129E-5 2.278E-4 2 3
48 23750231 MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. Pubmed 3.208E-7 4.380E-6 3.129E-5 2.278E-4 2 3
49 115747 Lysosomal dysfunctions associated with mutations at mouse pigment genes. Pubmed 3.208E-7 4.380E-6 3.129E-5 2.278E-4 2 3
50 12125811 Disorders of vesicles of lysosomal lineage: the Hermansky-Pudlak syndromes. Pubmed 3.208E-7 4.380E-6 3.129E-5 2.278E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 349 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:BLOC1S3 BLOC1S3 interactions 1.616E-23 5.638E-21 3.627E-20 5.638E-21 8 14
2 int:BLOC1S4 BLOC1S4 interactions 5.442E-20 9.497E-18 6.110E-17 1.899E-17 7 14
3 int:BLOC1S5 BLOC1S5 interactions 1.227E-18 1.428E-16 9.184E-16 4.283E-16 7 20
4 int:BLOC1S1 BLOC1S1 interactions 1.039E-17 9.069E-16 5.835E-15 3.627E-15 7 26
5 int:BCAS4 BCAS4 interactions 3.704E-17 2.586E-15 1.664E-14 1.293E-14 6 12
6 int:BLOC1S2 BLOC1S2 interactions 8.480E-17 4.933E-15 3.174E-14 2.960E-14 7 34
7 int:BLOC1S6 BLOC1S6 interactions 6.023E-16 3.003E-14 1.932E-13 2.102E-13 7 44
8 int:SNAPIN SNAPIN interactions 6.822E-15 2.976E-13 1.915E-12 2.381E-12 7 61
9 int:DTNBP1 DTNBP1 interactions 1.304E-14 5.055E-13 3.252E-12 4.549E-12 8 137
10 int:TEX35 TEX35 interactions 1.046E-11 3.650E-10 2.348E-9 3.650E-9 5 29
11 int:BORCS6 BORCS6 interactions 3.034E-10 9.626E-9 6.193E-8 1.059E-7 5 55
12 int:WASHC3 WASHC3 interactions 1.301E-9 3.784E-8 2.435E-7 4.541E-7 5 73
13 int:TRIM69 TRIM69 interactions 1.926E-8 5.171E-7 3.327E-6 6.722E-6 4 42
14 int:HPS6 HPS6 interactions 1.723E-7 4.295E-6 2.763E-5 6.013E-5 3 16
15 int:TRIML2 TRIML2 interactions 2.091E-7 4.865E-6 3.130E-5 7.298E-5 3 17
16 int:SYBU SYBU interactions 4.083E-7 8.906E-6 5.730E-5 1.425E-4 3 21
17 int:EXOC1 EXOC1 interactions 7.715E-7 1.544E-5 9.936E-5 2.693E-4 4 104
18 int:TSKS TSKS interactions 7.965E-7 1.544E-5 9.936E-5 2.780E-4 3 26
19 int:TCL1B TCL1B interactions 1.666E-6 3.061E-5 1.969E-4 5.816E-4 3 33
20 int:IFT20 IFT20 interactions 7.509E-6 1.310E-4 8.430E-4 2.621E-3 3 54
21 int:IKBIP IKBIP interactions 1.718E-5 2.855E-4 1.837E-3 5.995E-3 3 71
22 int:COG6 COG6 interactions 2.460E-5 3.902E-4 2.511E-3 8.585E-3 3 80
23 int:HPS3 HPS3 interactions 3.272E-5 4.965E-4 3.194E-3 1.142E-2 2 12
24 int:CCDC22 CCDC22 interactions 3.620E-5 5.265E-4 3.387E-3 1.264E-2 3 91
25 int:SNX7 SNX7 interactions 3.865E-5 5.396E-4 3.472E-3 1.349E-2 2 13
26 int:AP3S2 AP3S2 interactions 5.199E-5 6.978E-4 4.490E-3 1.814E-2 2 15
27 int:HPS5 HPS5 interactions 1.037E-4 1.341E-3 8.625E-3 3.620E-2 2 21
28 int:OSBPL9 OSBPL9 interactions 1.602E-4 1.997E-3 1.285E-2
5.590E-2
 2 26
29 int:SCOC SCOC interactions 2.595E-4 3.123E-3 2.009E-2
9.056E-2
 2 33
30 int:TRAK2 TRAK2 interactions 3.268E-4 3.801E-3 2.446E-2
1.140E-1
 2 37
31 int:AP3D1 AP3D1 interactions 6.716E-4 7.325E-3 4.713E-2
2.344E-1
 2 53
32 int:BUB1 BUB1 interactions 6.716E-4 7.325E-3 4.713E-2
2.344E-1
 2 53
33 int:AP3S1 AP3S1 interactions 8.890E-4 9.402E-3
6.049E-2
3.103E-1
 2 61
34 int:AP3M1 AP3M1 interactions 9.781E-4 1.004E-2
6.460E-2
3.414E-1
 2 64
35 int:HERC2 HERC2 interactions 1.102E-3 1.098E-2
7.067E-2
3.845E-1
 3 290
36 int:AP3B1 AP3B1 interactions 1.340E-3 1.299E-2
8.359E-2
4.677E-1
 2 75
37 int:PELP1 PELP1 interactions 1.449E-3 1.366E-2
8.791E-2
5.056E-1
 2 78
38 int:TRAF3IP1 TRAF3IP1 interactions 1.561E-3 1.434E-2
9.223E-2
5.448E-1
 2 81
39 int:SPAG5 SPAG5 interactions 1.638E-3 1.466E-2
9.431E-2
5.717E-1
 2 83
40 int:KLC1 KLC1 interactions 1.922E-3 1.672E-2
1.076E-1
6.709E-1
 2 90
41 int:VTI1B VTI1B interactions 1.965E-3 1.672E-2
1.076E-1
6.857E-1
 2 91
42 int:HPS4 HPS4 interactions 2.934E-3 2.438E-2
1.569E-1
1.000E0
 1 4
43 int:CCHCR1 CCHCR1 interactions 3.009E-3 2.442E-2
1.571E-1
1.000E0
 2 113
44 int:CCDC154 CCDC154 interactions 3.667E-3 2.723E-2
1.752E-1
1.000E0
 1 5
45 int:BORCS8 BORCS8 interactions 3.667E-3 2.723E-2
1.752E-1
1.000E0
 1 5
46 int:ELOVL7 ELOVL7 interactions 3.667E-3 2.723E-2
1.752E-1
1.000E0
 1 5
47 int:AKNAD1 AKNAD1 interactions 3.667E-3 2.723E-2
1.752E-1
1.000E0
 1 5
48 int:HAUS1 HAUS1 interactions 3.959E-3 2.862E-2
1.841E-1
1.000E0
 2 130
49 int:NDN NDN interactions 4.018E-3 2.862E-2
1.841E-1
1.000E0
 2 131
50 int:SPHK2 SPHK2 interactions 4.399E-3 3.070E-2
1.975E-1
1.000E0
 1 6
Show 45 more annotations

10: Cytoband [Display Chart] 12 input genes in category / 12 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p25.1-p24.3 6p25.1-p24.3 3.462E-4 4.155E-3 1.289E-2 4.155E-3 1 1
2 11p14 11p14 1.384E-3 8.302E-3 2.576E-2 1.661E-2 1 4
3 12q13-q14 12q13-q14 2.076E-3 8.302E-3 2.576E-2 2.491E-2 1 6
4 10q24.31 10q24.31 6.559E-3 1.897E-2
5.888E-2
7.871E-2
 1 19
5 10q24.32 10q24.32 8.966E-3 1.897E-2
5.888E-2
1.076E-1
 1 26
6 3q24 3q24 1.137E-2 1.897E-2
5.888E-2
1.364E-1
 1 33
7 5q14.1 5q14.1 1.342E-2 1.897E-2
5.888E-2
1.611E-1
 1 39
8 15q21.1 15q21.1 1.410E-2 1.897E-2
5.888E-2
1.693E-1
 1 41
9 Xp22.2 Xp22.2 1.445E-2 1.897E-2
5.888E-2
1.734E-1
 1 42
10 6p22.3 6p22.3 1.581E-2 1.897E-2
5.888E-2
1.897E-1
 1 46
11 4p16.1 4p16.1 3.039E-2 3.315E-2
1.029E-1
3.646E-1
 1 89
12 1q21.3 1q21.3 4.010E-2 4.010E-2
1.244E-1
4.812E-1
 1 118
Show 7 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 35 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$SREBP1 01 V$SREBP1 01 3.077E-4 1.077E-2 4.466E-2 1.077E-2 3 138
2 V$ARNT 02 V$ARNT 02 8.346E-4 1.461E-2
6.057E-2
 2.921E-2 3 194

12: Gene Family [Display Chart] 12 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 452 Biogenesis of lysosomal organelles complex 1 genenames.org 4.843E-23 2.422E-22 5.529E-22 2.422E-22 7 8
2 1038 Biogenesis of lysosomal organelles complex 2 genenames.org 2.192E-10 5.480E-10 1.251E-9 1.096E-9 3 3
3 1048 BLOC-1 related complex genenames.org 1.225E-8 2.042E-8 4.663E-8 6.127E-8 3 8
4 1039 Biogenesis of lysosomal organelles complex 3 genenames.org 1.319E-3 1.648E-3 3.764E-3 6.594E-3 1 2
5 388 RAB, member RAS oncogene GTPases genenames.org 4.205E-2 4.205E-2
9.602E-2
2.103E-1
 1 65

13: Coexpression [Display Chart] 13 input genes in category / 846 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9234 Genes down-regulated in CD8 T cells with STAT1 [GeneID=6772]: untreated versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 1.608E-4 2.063E-2
1.510E-1
1.361E-1
 3 196
2 M9236 Genes down-regulated in CD8 T cells with STAT4 [GeneID=6775]: untreated versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 1.657E-4 2.063E-2
1.510E-1
1.402E-1
 3 198
3 M3892 Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 2.063E-2
1.510E-1
1.423E-1
 3 199
4 M4753 Genes down-regulated in comparison of LSK versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.063E-2
1.510E-1
1.444E-1
 3 200
5 M6411 Genes down-regulated in monocytes: untreated versus M. tuberculosis 19 kDa lipopeptide (24h). MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.063E-2
1.510E-1
1.444E-1
 3 200
6 M3725 Genes down-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with poly(I:C) (TLR3 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.063E-2
1.510E-1
1.444E-1
 3 200
7 M6606 Genes up-regulated in bone marrow-derived macrophages: untreated (0 min) versus IL6 [GeneID=3569] and LPS (45 min). MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.063E-2
1.510E-1
1.444E-1
 3 200
8 M1632 Strongly down-regulated at 2-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.571E-4 4.834E-2
3.537E-1
3.867E-1
 2 57
Show 3 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 359 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 7 input genes in category / 31 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 13 input genes in category / 403 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-636:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.494E-4 3.842E-2
2.527E-1
6.023E-2
 2 101
2 hsa-miR-639:mirSVR highEffct hsa-miR-639:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.835E-4 3.842E-2
2.527E-1
1.546E-1
 2 162
3 hsa-miR-6818-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.835E-4 3.842E-2
2.527E-1
1.546E-1
 2 162
4 hsa-miR-363-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.376E-4 3.842E-2
2.527E-1
2.167E-1
 2 192
5 hsa-miR-122*:mirSVR highEffct hsa-miR-122*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.300E-4 3.842E-2
2.527E-1
2.942E-1
 2 224
6 hsa-miR-1296:mirSVR highEffct hsa-miR-1296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.959E-4 3.842E-2
2.527E-1
3.208E-1
 2 234
7 hsa-miR-532-3p:TargetScan hsa-miR-532-3p TargetScan 8.647E-4 3.842E-2
2.527E-1
3.485E-1
 2 244
8 hsa-miR-5186:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.145E-4 3.842E-2
2.527E-1
3.685E-1
 2 251
9 hsa-miR-1179:PITA hsa-miR-1179:PITA TOP PITA 9.289E-4 3.842E-2
2.527E-1
3.744E-1
 2 253
10 hsa-miR-548az-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.049E-3 3.842E-2
2.527E-1
4.226E-1
 2 269
11 hsa-miR-548t-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.049E-3 3.842E-2
2.527E-1
4.226E-1
 2 269
12 hsa-miR-627-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.370E-3 4.601E-2
3.026E-1
5.521E-1
 2 308
Show 7 more annotations

17: Drug [Display Chart] 13 input genes in category / 1560 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000043226 fenarimol Stitch 9.856E-28 1.538E-24 1.219E-23 1.538E-24 11 59
2 CID000068933 BT325 Stitch 6.818E-27 5.318E-24 4.217E-23 1.064E-23 10 36
3 CID000012219 ethylmethylamine Stitch 2.271E-16 1.181E-13 9.363E-13 3.542E-13 7 49
4 CID000024572 lead arsenate Stitch 1.805E-14 7.038E-12 5.581E-11 2.815E-11 7 89
5 CID001008511 1,4-bis-(phenoxyacetyl)piperazine Stitch 1.380E-11 4.306E-9 3.415E-8 2.153E-8 7 226
6 CID000027991 DDAVP Stitch 3.588E-11 9.328E-9 7.397E-8 5.597E-8 6 123
7 CID000004386 diphenylamine-2-carboxylate Stitch 2.214E-10 4.934E-8 3.913E-7 3.454E-7 6 166
8 CID000157350 hydroxyl radical Stitch 6.898E-8 1.345E-5 1.067E-4 1.076E-4 5 206
9 CID000000281 carbon monoxide Stitch 1.274E-7 2.208E-5 1.751E-4 1.988E-4 5 233
10 CID000014786 oxocobalt Stitch 1.301E-6 2.029E-4 1.609E-3 2.029E-3 3 39
11 CID000000379 octanoate Stitch 2.579E-6 3.658E-4 2.901E-3 4.024E-3 4 181
12 CID000065863 sertaconazole Stitch 5.594E-6 7.272E-4 5.766E-3 8.726E-3 4 220
13 ctd:C523184 mocetinostat CTD 2.686E-5 3.223E-3 2.556E-2 4.190E-2 3 106
14 7392 DN 0175029-0000 [211245-78-2]; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.500E-4 1.653E-2
1.311E-1
2.340E-1
 3 189
15 2951 DN Piribedil hydrochloride [78213-63-5]; Down 200; 12uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.670E-4 1.653E-2
1.311E-1
2.606E-1
 3 196
16 7069 DN 0198306-0000 [212631-61-3]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.696E-4 1.653E-2
1.311E-1
2.645E-1
 3 197
17 CID011022912 11-[(2S,3R)-3-amyloxiran-2-yl]undecanoic acid Stitch 2.190E-4 2.009E-2
1.593E-1
3.416E-1
 2 39
18 CID001536427 AC1LTNWX Stitch 4.855E-4 3.062E-2
2.428E-1
7.574E-1
 2 58
19 CID000011191 allyl ethyl ether Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
20 CID000593212 2-quinoxalinecarbonitrile Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
21 CID000161968 nitroglutethimide Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
22 CID000425002 bis(benzonitrile)palladium dichloride Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
23 CID000588990 3-methyl-1,8-naphthyridine Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
24 CID005287963 CoA-CoA Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
25 CID003036010 25-doxyl-27-norcholesterol Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
26 CID000132791 FIAZP Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
27 CID000126370 NSC 335154 Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
28 CID003250238 AC1MLTDL Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
29 CID005490620 chloroxymorphamine Stitch 5.692E-4 3.062E-2
2.428E-1
8.879E-1
 1 1
30 CID000065049 arabinosylthymine Stitch 7.681E-4 3.994E-2
3.167E-1
1.000E0
 2 73
31 CID000008686 baron Stitch 8.988E-4 4.523E-2
3.587E-1
1.000E0
 2 79
Show 26 more annotations

18: Disease [Display Chart] 13 input genes in category / 142 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0079504 Hermanski-Pudlak Syndrome DisGeNET BeFree 1.117E-15 1.373E-13 7.604E-13 1.587E-13 7 44
2 OMIN:203300 HERMANSKY-PUDLAK SYNDROME; HPS OMIM 2.902E-15 1.373E-13 7.604E-13 4.120E-13 5 7
3 C2931875 Albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells DisGeNET Curated 2.902E-15 1.373E-13 7.604E-13 4.120E-13 5 7
4 C0242994 Hantavirus Infections DisGeNET BeFree 5.147E-15 1.827E-13 1.012E-12 7.309E-13 7 54
5 C0162835 Hypopigmentation disorder DisGeNET Curated 2.485E-7 7.056E-6 3.907E-5 3.528E-5 4 72
6 C1876214 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT DisGeNET BeFree 1.456E-6 3.446E-5 1.908E-4 2.068E-4 3 29
7 C3888001 HERMANSKY-PUDLAK SYNDROME 3 DisGeNET Curated 3.561E-6 7.224E-5 4.000E-4 5.057E-4 2 4
8 C0001916 Albinism DisGeNET Curated 4.886E-6 8.673E-5 4.802E-4 6.938E-4 3 43
9 C0333913 Achromasia DisGeNET Curated 3.254E-5 5.134E-4 2.843E-3 4.621E-3 2 11
10 C0078917 Albinism, Ocular DisGeNET Curated 6.201E-5 8.806E-4 4.875E-3 8.806E-3 2 15
11 C0078918 Albinism, Oculocutaneous DisGeNET Curated 1.237E-4 1.597E-3 8.840E-3 1.756E-2 2 21
12 C1969516 Aberrant melanosome maturation DisGeNET Curated 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
13 cv:C3280026 Hermansky-Pudlak syndrome 9 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
14 cv:C3279756 Hermansky-Pudlak syndrome 7 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
15 C0543910 Psychosis, childhood onset DisGeNET BeFree 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
16 C0333007 Congenital pigmentation DisGeNET BeFree 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
17 C0233765 Hallucinations, Olfactory DisGeNET BeFree 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
18 cv:CN068617 Hermansky-Pudlak syndrome 6 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
19 C3484357 HERMANSKY-PUDLAK SYNDROME 4 DisGeNET BeFree 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
20 cv:C1842362 Hermansky Pudlak syndrome 2 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
21 cv:CN068618 Hermansky-Pudlak syndrome 5 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
22 C3280026 HERMANSKY-PUDLAK SYNDROME 9 DisGeNET Curated 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
23 cv:CN068829 Hermansky-Pudlak syndrome 3 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
24 OMIN:608233 HERMANSKY-PUDLAK SYNDROME 2; HPS2 OMIM 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
25 C3279756 HERMANSKY-PUDLAK SYNDROME 7 DisGeNET Curated 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
26 cv:C3484357 Hermansky-Pudlak syndrome 4 Clinical Variations 8.022E-4 4.381E-3 2.426E-2
1.139E-1
 1 1
27 C3888004 HERMANSKY-PUDLAK SYNDROME 5 DisGeNET Curated 1.604E-3 8.435E-3 4.670E-2
2.277E-1
 1 2
28 C1842362 HERMANSKY-PUDLAK SYNDROME 2 DisGeNET Curated 3.205E-3 1.570E-2
8.690E-2
4.552E-1
 1 4
29 C2931206 Usher syndrome, type 1B DisGeNET Curated 3.205E-3 1.570E-2
8.690E-2
4.552E-1
 1 4
30 C0392386 Decreased platelet count DisGeNET Curated 3.514E-3 1.663E-2
9.208E-2
4.989E-1
 2 112
31 C0743072 Depression, psychotic DisGeNET Curated 4.005E-3 1.784E-2
9.880E-2
5.687E-1
 1 5
32 C0206062 Lung Diseases, Interstitial DisGeNET Curated 4.021E-3 1.784E-2
9.880E-2
5.710E-1
 2 120
33 C1846343 Bartter syndrome, type 3 DisGeNET Curated 4.804E-3 2.067E-2
1.145E-1
6.822E-1
 1 6
34 C1848638 USHER SYNDROME, TYPE IB (disorder) DisGeNET BeFree 5.603E-3 2.340E-2
1.296E-1
7.956E-1
 1 7
35 C0700501 Congenital nystagmus DisGeNET Curated 6.401E-3 2.457E-2
1.360E-1
9.090E-1
 1 8
36 C1849221 Fair hair DisGeNET Curated 6.401E-3 2.457E-2
1.360E-1
9.090E-1
 1 8
37 C0239801 Blonde hair DisGeNET Curated 6.401E-3 2.457E-2
1.360E-1
9.090E-1
 1 8
38 C0033937 Psychoses, Drug DisGeNET Curated 7.199E-3 2.556E-2
1.415E-1
1.000E0
 1 9
39 C0235522 Disorder of vein DisGeNET BeFree 7.199E-3 2.556E-2
1.415E-1
1.000E0
 1 9
40 C0270458 Severe major depression with psychotic features DisGeNET Curated 7.199E-3 2.556E-2
1.415E-1
1.000E0
 1 9
41 C0398794 Hypopigmentation-immunodeficiency disease DisGeNET BeFree 7.996E-3 2.703E-2
1.497E-1
1.000E0
 1 10
42 C1328407 Hip Dysplasia DisGeNET Curated 7.996E-3 2.703E-2
1.497E-1
1.000E0
 1 10
43 C0032197 Platelet Storage Pool Deficiency DisGeNET BeFree 8.792E-3 2.903E-2
1.607E-1
1.000E0
 1 11
44 C0151891 Retinal depigmentation DisGeNET Curated 9.588E-3 3.094E-2
1.713E-1
1.000E0
 1 12
45 C1306557 Chronic venous insufficiency DisGeNET BeFree 1.038E-2 3.276E-2
1.814E-1
1.000E0
 1 13
46 C0085581 Restrictive lung disease DisGeNET Curated 1.118E-2 3.450E-2
1.910E-1
1.000E0
 1 14
47 cv:C0036341 Schizophrenia Clinical Variations 1.197E-2 3.617E-2
2.002E-1
1.000E0
 1 15
48 C0019101 Hemorrhagic Fever with Renal Syndrome DisGeNET BeFree 1.514E-2 4.479E-2
2.480E-1
1.000E0
 1 19
49 C0036939 Shared Paranoid Disorder DisGeNET Curated 1.672E-2 4.749E-2
2.629E-1
1.000E0
 1 21
50 C0007965 Chediak-Higashi Syndrome DisGeNET Curated 1.672E-2 4.749E-2
2.629E-1
1.000E0
 1 21
Show 45 more annotations