Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc58_19, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 62 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004197 cysteine-type endopeptidase activity 7.335E-5 4.548E-3 2.143E-2 4.548E-3 3 86
2 GO:0004029 aldehyde dehydrogenase (NAD) activity 1.488E-4 4.613E-3 2.174E-2 9.227E-3 2 19
3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6.375E-4 1.040E-2 4.899E-2 3.953E-2 2 39
4 GO:0004175 endopeptidase activity 8.269E-4 1.040E-2 4.899E-2
5.126E-2
 4 457
5 GO:0008234 cysteine-type peptidase activity 8.916E-4 1.040E-2 4.899E-2
5.528E-2
 3 201
6 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.006E-3 1.040E-2 4.899E-2
6.237E-2
 2 49
7 GO:1990698 palmitoleoyltransferase activity 1.928E-3 1.571E-2
7.403E-2
1.196E-1
 1 2
8 GO:0004843 thiol-dependent ubiquitin-specific protease activity 2.339E-3 1.571E-2
7.403E-2
1.450E-1
 2 75
9 GO:0003777 microtubule motor activity 2.463E-3 1.571E-2
7.403E-2
1.527E-1
 2 77
10 GO:0015631 tubulin binding 2.625E-3 1.571E-2
7.403E-2
1.627E-1
 3 293
11 GO:0070404 NADH binding 2.891E-3 1.571E-2
7.403E-2
1.792E-1
 1 3
12 GO:0019145 aminobutyraldehyde dehydrogenase activity 3.853E-3 1.571E-2
7.403E-2
2.389E-1
 1 4
13 GO:0004095 carnitine O-palmitoyltransferase activity 3.853E-3 1.571E-2
7.403E-2
2.389E-1
 1 4
14 GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity 3.853E-3 1.571E-2
7.403E-2
2.389E-1
 1 4
15 GO:0051082 unfolded protein binding 4.358E-3 1.571E-2
7.403E-2
2.702E-1
 2 103
16 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity 4.779E-3 1.571E-2
7.403E-2
2.963E-1
 2 108
17 GO:0101005 ubiquitinyl hydrolase activity 4.779E-3 1.571E-2
7.403E-2
2.963E-1
 2 108
18 GO:0031694 alpha-2A adrenergic receptor binding 4.814E-3 1.571E-2
7.403E-2
2.985E-1
 1 5
19 GO:0042609 CD4 receptor binding 4.814E-3 1.571E-2
7.403E-2
2.985E-1
 1 5
20 GO:0019783 ubiquitin-like protein-specific protease activity 5.771E-3 1.789E-2
8.431E-2
3.578E-1
 2 119
21 GO:0003774 motor activity 7.055E-3 2.083E-2
9.815E-2
4.374E-1
 2 132
22 GO:0016887 ATPase activity 8.472E-3 2.332E-2
1.099E-1
5.252E-1
 3 446
23 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 8.650E-3 2.332E-2
1.099E-1
5.363E-1
 1 9
24 GO:0004176 ATP-dependent peptidase activity 9.606E-3 2.482E-2
1.169E-1
5.956E-1
 1 10
25 GO:0031681 G-protein beta-subunit binding 1.152E-2 2.856E-2
1.346E-1
7.141E-1
 1 12
26 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed 1.628E-2 3.882E-2
1.829E-1
1.000E0
 1 17
27 GO:0008017 microtubule binding 1.775E-2 4.025E-2
1.897E-1
1.000E0
 2 214
28 GO:1990939 ATP-dependent microtubule motor activity 1.818E-2 4.025E-2
1.897E-1
1.000E0
 1 19
29 GO:0031690 adrenergic receptor binding 1.913E-2 4.089E-2
1.927E-1
1.000E0
 1 20
30 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2.007E-2 4.148E-2
1.955E-1
1.000E0
 1 21
31 GO:0008242 omega peptidase activity 2.196E-2 4.256E-2
2.005E-1
1.000E0
 1 23
32 GO:0004622 lysophospholipase activity 2.196E-2 4.256E-2
2.005E-1
1.000E0
 1 23
Show 27 more annotations

2: GO: Biological Process [Display Chart] 19 input genes in category / 303 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030705 cytoskeleton-dependent intracellular transport 9.135E-6 2.768E-3 1.742E-2 2.768E-3 4 134
2 GO:0007018 microtubule-based movement 8.254E-5 1.250E-2
7.868E-2
 2.501E-2 4 235
3 GO:0048193 Golgi vesicle transport 3.406E-4 3.440E-2
2.164E-1
1.032E-1
 4 340

3: GO: Cellular Component [Display Chart] 19 input genes in category / 71 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031904 endosome lumen 2.152E-6 1.528E-4 7.405E-4 1.528E-4 3 26
2 GO:0044440 endosomal part 5.341E-5 1.557E-3 7.549E-3 3.792E-3 5 434
3 GO:0032588 trans-Golgi network membrane 7.075E-5 1.557E-3 7.549E-3 5.023E-3 3 82
4 GO:0030117 membrane coat 1.097E-4 1.557E-3 7.549E-3 7.787E-3 3 95
5 GO:0048475 coated membrane 1.097E-4 1.557E-3 7.549E-3 7.787E-3 3 95
6 GO:0005775 vacuolar lumen 1.982E-4 2.345E-3 1.137E-2 1.407E-2 3 116
7 GO:0030131 clathrin adaptor complex 4.027E-4 4.085E-3 1.980E-2 2.859E-2 2 30
8 GO:1904115 axon cytoplasm 5.812E-4 5.158E-3 2.500E-2 4.126E-2 2 36
9 GO:0030119 AP-type membrane coat adaptor complex 9.492E-4 7.120E-3 3.451E-2
6.739E-2
 2 46
10 GO:0030118 clathrin coat 1.166E-3 7.120E-3 3.451E-2
8.277E-2
 2 51
11 GO:0005802 trans-Golgi network 1.216E-3 7.120E-3 3.451E-2
8.635E-2
 3 216
12 GO:0032592 integral component of mitochondrial membrane 1.306E-3 7.120E-3 3.451E-2
9.273E-2
 2 54
13 GO:0005871 kinesin complex 1.355E-3 7.120E-3 3.451E-2
9.618E-2
 2 55
14 GO:0098573 intrinsic component of mitochondrial membrane 1.404E-3 7.120E-3 3.451E-2
9.968E-2
 2 56
15 GO:0032838 plasma membrane bounded cell projection cytoplasm 1.773E-3 8.392E-3 4.068E-2
1.259E-1
 2 63
16 GO:0005745 m-AAA complex 1.993E-3 8.842E-3 4.286E-2
1.415E-1
 1 2
17 GO:0005905 clathrin-coated pit 2.122E-3 8.864E-3 4.296E-2
1.507E-1
 2 69
18 GO:0031301 integral component of organelle membrane 2.631E-3 1.038E-2
5.030E-2
1.868E-1
 3 283
19 GO:0031300 intrinsic component of organelle membrane 2.987E-3 1.116E-2
5.411E-2
2.121E-1
 3 296
20 GO:0098791 Golgi subcompartment 3.920E-3 1.392E-2
6.745E-2
2.783E-1
 3 326
21 GO:0031984 organelle subcompartment 4.446E-3 1.503E-2
7.285E-2
3.157E-1
 3 341
22 GO:0031313 extrinsic component of endosome membrane 4.975E-3 1.605E-2
7.781E-2
3.532E-1
 1 5
23 GO:0000138 Golgi trans cisterna 6.958E-3 2.148E-2
1.041E-1
4.940E-1
 1 7
24 GO:0000306 extrinsic component of vacuolar membrane 7.948E-3 2.338E-2
1.133E-1
5.643E-1
 1 8
25 GO:0005874 microtubule 8.231E-3 2.338E-2
1.133E-1
5.844E-1
 3 426
26 GO:0005832 chaperonin-containing T-complex 8.937E-3 2.441E-2
1.183E-1
6.346E-1
 1 9
27 GO:0035253 ciliary rootlet 9.926E-3 2.610E-2
1.265E-1
7.047E-1
 1 10
28 GO:0005875 microtubule associated complex 1.039E-2 2.634E-2
1.277E-1
7.375E-1
 2 156
29 GO:0002199 zona pellucida receptor complex 1.091E-2 2.672E-2
1.295E-1
7.748E-1
 1 11
30 GO:0044455 mitochondrial membrane part 1.497E-2 3.543E-2
1.717E-1
1.000E0
 2 189
31 GO:0043209 myelin sheath 1.697E-2 3.888E-2
1.884E-1
1.000E0
 2 202
32 GO:0031307 integral component of mitochondrial outer membrane 2.074E-2 4.601E-2
2.230E-1
1.000E0
 1 21
33 GO:0031306 intrinsic component of mitochondrial outer membrane 2.171E-2 4.672E-2
2.264E-1
1.000E0
 1 22
Show 28 more annotations

4: Human Phenotype [Display Chart] 16 input genes in category / 717 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001258 Spastic paraplegia 1.078E-18 7.728E-16 5.528E-15 7.728E-16 12 86
2 HP:0002061 Lower limb spasticity 7.232E-17 2.593E-14 1.854E-13 5.185E-14 12 120
3 HP:0003487 Babinski sign 3.588E-16 8.575E-14 6.134E-13 2.573E-13 13 195
4 HP:0010550 Paraplegia 1.359E-15 2.437E-13 1.743E-12 9.747E-13 12 152
5 HP:0010551 Paraplegia/paraparesis 1.242E-14 1.781E-12 1.274E-11 8.905E-12 12 182
6 HP:0010549 Weakness due to upper motor neuron dysfunction 1.064E-11 1.272E-9 9.096E-9 7.630E-9 13 428
7 HP:0007340 Lower limb muscle weakness 1.957E-8 2.005E-6 1.434E-5 1.403E-5 6 58
8 HP:0002460 Distal muscle weakness 6.060E-6 5.431E-4 3.885E-3 4.345E-3 6 151
9 HP:0002064 Spastic gait 6.822E-6 5.435E-4 3.887E-3 4.891E-3 4 39
10 HP:0003693 Distal amyotrophy 1.804E-5 1.289E-3 9.223E-3 1.293E-2 5 105
11 HP:0002127 Abnormal upper motor neuron morphology 1.978E-5 1.289E-3 9.223E-3 1.418E-2 5 107
12 HP:0003690 Limb muscle weakness 2.727E-5 1.629E-3 1.166E-2 1.955E-2 6 196
13 HP:0003474 Sensory impairment 3.722E-5 2.053E-3 1.469E-2 2.669E-2 6 207
14 HP:0009127 Abnormality of the musculature of the limbs 4.129E-5 2.114E-3 1.512E-2 2.960E-2 7 319
15 HP:0002166 Impaired vibration sensation in the lower limbs 5.477E-5 2.618E-3 1.873E-2 3.927E-2 3 23
16 HP:0003202 Skeletal muscle atrophy 7.090E-5 3.177E-3 2.273E-2
5.084E-2
 8 483
17 HP:0002599 Head titubation 1.077E-4 4.543E-3 3.249E-2
7.722E-2
 2 5
18 HP:0000876 Oligomenorrhea 1.238E-4 4.930E-3 3.526E-2
8.873E-2
 3 30
19 HP:0030187 Titubation 1.612E-4 6.084E-3 4.352E-2
1.156E-1
 2 6
20 HP:0030188 Tremor by anatomical site 1.809E-4 6.485E-3 4.639E-2
1.297E-1
 3 34
21 HP:0001272 Cerebellar atrophy 2.276E-4 7.771E-3
5.558E-2
1.632E-1
 6 286
22 HP:0002936 Distal sensory impairment 2.451E-4 7.987E-3
5.713E-2
1.757E-1
 4 96
23 HP:0007368 Atrophy/Degeneration affecting the cerebellum 2.600E-4 8.104E-3
5.797E-2
1.864E-1
 6 293
24 HP:0001761 Pes cavus 3.403E-4 1.017E-2
7.272E-2
2.440E-1
 5 194
25 HP:0006827 Atrophy of the spinal cord 3.847E-4 1.103E-2
7.891E-2
2.758E-1
 2 9
26 HP:0002495 Impaired vibratory sensation 4.193E-4 1.156E-2
8.270E-2
3.006E-1
 3 45
27 HP:0002457 Abnormal head movements 4.799E-4 1.274E-2
9.115E-2
3.441E-1
 2 10
28 HP:0007344 Atrophy/Degeneration involving the spinal cord 5.854E-4 1.499E-2
1.072E-1
4.197E-1
 2 11
29 HP:0000763 Sensory neuropathy 7.043E-4 1.741E-2
1.246E-1
5.050E-1
 6 352
30 HP:0002169 Clonus 8.433E-4 2.015E-2
1.442E-1
6.046E-1
 3 57
31 HP:0002066 Gait ataxia 1.033E-3 2.358E-2
1.687E-1
7.404E-1
 4 140
32 HP:0002346 Head tremor 1.109E-3 2.358E-2
1.687E-1
7.949E-1
 2 15
33 HP:0000181 Macrostomia 1.118E-3 2.358E-2
1.687E-1
8.017E-1
 4 143
34 HP:0000154 Wide mouth 1.118E-3 2.358E-2
1.687E-1
8.017E-1
 4 143
35 HP:0011448 Ankle clonus 1.265E-3 2.590E-2
1.853E-1
9.067E-1
 2 16
36 HP:0000341 Narrow forehead 1.536E-3 3.058E-2
2.188E-1
1.000E0
 3 70
37 HP:0030182 Tetraplegia/tetraparesis 1.948E-3 3.748E-2
2.681E-1
1.000E0
 3 76
38 HP:0000845 Growth hormone excess 1.986E-3 3.748E-2
2.681E-1
1.000E0
 2 20
39 HP:0002380 Fasciculations 2.099E-3 3.859E-2
2.760E-1
1.000E0
 3 78
40 HP:0002839 Urinary bladder sphincter dysfunction 2.405E-3 4.312E-2
3.084E-1
1.000E0
 2 22
41 HP:0001260 Dysarthria 2.718E-3 4.753E-2
3.400E-1
1.000E0
 6 455
42 HP:0000280 Coarse facial features 2.786E-3 4.757E-2
3.402E-1
1.000E0
 4 183
Show 37 more annotations

5: Mouse Phenotype [Display Chart] 16 input genes in category / 561 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 19 input genes in category / 170 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR009028 Coatomer/calthrin app sub C InterPro 2.718E-5 2.336E-3 1.335E-2 4.621E-3 2 8
2 PF01602 Adaptin N Pfam 1.015E-4 2.336E-3 1.335E-2 1.726E-2 2 15
3 IPR002553 Clathrin/coatomer adapt-like N InterPro 1.015E-4 2.336E-3 1.335E-2 1.726E-2 2 15
4 PS00070 ALDEHYDE DEHYDR CYS PROSITE 1.476E-4 2.336E-3 1.335E-2 2.510E-2 2 18
5 PS00687 ALDEHYDE DEHYDR GLU PROSITE 1.476E-4 2.336E-3 1.335E-2 2.510E-2 2 18
6 3.40.605.10 - Gene3D 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
7 IPR016162 Ald DH N InterPro 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
8 PF00171 Aldedh Pfam 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
9 IPR016163 Ald DH C InterPro 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
10 IPR016161 Ald DH/histidinol DH InterPro 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
11 IPR015590 Aldehyde DH dom InterPro 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
12 3.40.309.10 - Gene3D 1.649E-4 2.336E-3 1.335E-2 2.804E-2 2 19
13 IPR019821 Kinesin motor CS InterPro 7.804E-4 5.224E-3 2.986E-2
1.327E-1
 2 41
14 IPR027640 Kinesin-like fam InterPro 8.583E-4 5.224E-3 2.986E-2
1.459E-1
 2 43
15 3.40.850.10 - Gene3D 8.987E-4 5.224E-3 2.986E-2
1.528E-1
 2 44
16 SM00129 KISc SMART 8.987E-4 5.224E-3 2.986E-2
1.528E-1
 2 44
17 PF00225 Kinesin Pfam 8.987E-4 5.224E-3 2.986E-2
1.528E-1
 2 44
18 PS50067 KINESIN MOTOR 2 PROSITE 8.987E-4 5.224E-3 2.986E-2
1.528E-1
 2 44
19 IPR001752 Kinesin motor dom InterPro 8.987E-4 5.224E-3 2.986E-2
1.528E-1
 2 44
20 PS00411 KINESIN MOTOR 1 PROSITE 8.987E-4 5.224E-3 2.986E-2
1.528E-1
 2 44
21 PF14807 AP4E app platf Pfam 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
22 IPR009617 Seipin InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
23 IPR030297 UCHL1 InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
24 IPR011408 Aldehyde DH InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
25 IPR029643 CAPN1 InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
26 PF06775 Seipin Pfam 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
27 IPR028269 AP4E1 C InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
28 IPR012718 Chap CCT epsi InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
29 IPR017109 AP4 complex esu InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
30 IPR030690 NDRG2 InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
31 IPR026151 Maspardin InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
32 IPR033512 TFG InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
33 IPR001423 LysoPLipase patatin CS InterPro 1.014E-3 5.224E-3 2.986E-2
1.724E-1
 1 1
34 PF07718 Coatamer beta C Pfam 2.027E-3 9.070E-3
5.184E-2
3.446E-1
 1 2
35 IPR011710 Coatomer bsu C InterPro 2.027E-3 9.070E-3
5.184E-2
3.446E-1
 1 2
36 PS01237 UPF0028 PROSITE 2.027E-3 9.070E-3
5.184E-2
3.446E-1
 1 2
37 IPR011546 Pept M41 FtsH extracell InterPro 2.027E-3 9.070E-3
5.184E-2
3.446E-1
 1 2
38 PF06480 FtsH ext Pfam 2.027E-3 9.070E-3
5.184E-2
3.446E-1
 1 2
39 PF09066 B2-adapt-app C Pfam 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
40 IPR005936 FtsH InterPro 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
41 IPR032476 CPT N InterPro 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
42 IPR015063 USP8 dimer InterPro 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
43 PF01434 Peptidase M41 Pfam 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
44 IPR000642 Peptidase M41 InterPro 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
45 PF16484 CPT N Pfam 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
46 PF08969 USP8 dimer Pfam 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
47 IPR016342 AP complex bsu 1 2 4 InterPro 3.040E-3 1.099E-2
6.284E-2
5.167E-1
 1 3
48 PF01088 Peptidase C12 Pfam 4.051E-3 1.252E-2
7.157E-2
6.886E-1
 1 4
49 PS00140 UCH 1 PROSITE 4.051E-3 1.252E-2
7.157E-2
6.886E-1
 1 4
50 IPR001578 Peptidase C12 UCH InterPro 4.051E-3 1.252E-2
7.157E-2
6.886E-1
 1 4
Show 45 more annotations

7: Pathway [Display Chart] 16 input genes in category / 160 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269883 Lysosome Vesicle Biogenesis BioSystems: REACTOME 1.212E-5 1.939E-3 1.096E-2 1.939E-3 3 36
2 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 1.025E-4 5.468E-3 3.093E-2 1.641E-2 3 73
3 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 1.025E-4 5.468E-3 3.093E-2 1.641E-2 3 73
4 P04372 5-Hydroxytryptamine degredation PantherDB 2.341E-4 9.364E-3
5.296E-2
 3.745E-2 2 18
5 PW:0000058 fatty acid metabolic Pathway Ontology 3.856E-4 1.234E-2
6.979E-2
6.170E-2
 2 23
6 99052 Lysosome BioSystems: KEGG 4.797E-4 1.279E-2
7.235E-2
7.675E-2
 3 123
7 PW:0000153 glycerolipid metabolic Pathway Ontology 6.596E-4 1.508E-2
8.527E-2
1.055E-1
 2 30
8 1269378 Kinesins BioSystems: REACTOME 1.356E-3 2.354E-2
1.331E-1
2.170E-1
 2 43
9 82935 Fatty acid degradation BioSystems: KEGG 1.419E-3 2.354E-2
1.331E-1
2.271E-1
 2 44
10 MAP00071 Fatty acid metabolism MAP00071 Fatty acid metabolism GenMAPP 1.551E-3 2.354E-2
1.331E-1
2.481E-1
 2 46
11 MAP00561 Glycerolipid metabolism MAP00561 Glycerolipid metabolism GenMAPP 1.618E-3 2.354E-2
1.331E-1
2.589E-1
 2 47
12 1269882 Golgi Associated Vesicle Biogenesis BioSystems: REACTOME 2.372E-3 3.162E-2
1.788E-1
3.795E-1
 2 57
13 1268783 Metabolism of serotonin BioSystems: REACTOME 2.569E-3 3.162E-2
1.788E-1
4.110E-1
 1 2
14 547500 phenylethylamine degradation I BioSystems: BIOCYC 3.851E-3 3.851E-2
2.178E-1
6.161E-1
 1 3
15 1268782 Serotonin clearance from the synaptic cleft BioSystems: REACTOME 3.851E-3 3.851E-2
2.178E-1
6.161E-1
 1 3
16 PW:0000183 the proteolytic involving calcium-dependent proteases Pathway Ontology 3.851E-3 3.851E-2
2.178E-1
6.161E-1
 1 3
17 102279 Endocytosis BioSystems: KEGG 4.122E-3 3.879E-2
2.194E-1
6.595E-1
 3 260
18 1383042 COPI-dependent Golgi-to-ER retrograde traffic BioSystems: REACTOME 4.959E-3 3.910E-2
2.211E-1
7.935E-1
 2 83
19 PW:0000062 ascorbate and aldarate metabolic Pathway Ontology 5.131E-3 3.910E-2
2.211E-1
8.210E-1
 1 4
20 142309 ethanol degradation II BioSystems: BIOCYC 5.131E-3 3.910E-2
2.211E-1
8.210E-1
 1 4
21 142308 ethanol degradation IV BioSystems: BIOCYC 5.131E-3 3.910E-2
2.211E-1
8.210E-1
 1 4
22 PW:0000294 altered ubiquitin/proteasome degradation Pathway Ontology 6.410E-3 4.103E-2
2.320E-1
1.000E0
 1 5
23 545348 mitochondrial L-carnitine shuttle BioSystems: BIOCYC 6.410E-3 4.103E-2
2.320E-1
1.000E0
 1 5
24 PW:0000144 ubiquitin/proteasome degradation Pathway Ontology 6.410E-3 4.103E-2
2.320E-1
1.000E0
 1 5
25 142307 oxidative ethanol degradation III BioSystems: BIOCYC 6.410E-3 4.103E-2
2.320E-1
1.000E0
 1 5
26 PW:0000185 limonene and pinene degradation Pathway Ontology 7.688E-3 4.556E-2
2.576E-1
1.000E0
 1 6
27 545353 serotonin degradation BioSystems: BIOCYC 7.688E-3 4.556E-2
2.576E-1
1.000E0
 1 6
28 1383041 Golgi-to-ER retrograde transport BioSystems: REACTOME 8.713E-3 4.781E-2
2.704E-1
1.000E0
 2 111
29 SMP00007 Beta-Alanine Metabolism SMPDB 8.964E-3 4.781E-2
2.704E-1
1.000E0
 1 7
30 1383063 Glycerophospholipid catabolism BioSystems: REACTOME 8.964E-3 4.781E-2
2.704E-1
1.000E0
 1 7
Show 25 more annotations

8: Pubmed [Display Chart] 19 input genes in category / 2533 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20301682 Hereditary Spastic Paraplegia Overview Pubmed 7.302E-27 1.850E-23 1.556E-22 1.850E-23 11 63
2 10066790 AP-4, a novel protein complex related to clathrin adaptors. Pubmed 4.173E-10 3.524E-7 2.965E-6 1.057E-6 3 4
3 30543385 AP-4-Associated Hereditary Spastic Paraplegia Pubmed 4.173E-10 3.524E-7 2.965E-6 1.057E-6 3 4
4 10436028 Characterization of a fourth adaptor-related protein complex. Pubmed 1.043E-9 6.605E-7 5.558E-6 2.642E-6 3 5
5 17420921 The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome. Pubmed 1.250E-8 6.331E-6 5.327E-5 3.165E-5 3 10
6 18341993 Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Pubmed 1.718E-8 7.252E-6 6.102E-5 4.351E-5 3 11
7 19184135 Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1. Pubmed 2.345E-7 8.484E-5 7.139E-4 5.939E-4 2 2
8 9714600 The AP-3 complex: a coat of many colours. Pubmed 4.201E-7 1.330E-4 1.119E-3 1.064E-3 3 30
9 21620353 Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. Pubmed 7.032E-7 1.619E-4 1.363E-3 1.781E-3 2 3
10 26542808 Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. Pubmed 7.032E-7 1.619E-4 1.363E-3 1.781E-3 2 3
11 26544806 Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. Pubmed 7.032E-7 1.619E-4 1.363E-3 1.781E-3 2 3
12 11707398 Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs). Pubmed 2.343E-6 4.945E-4 4.161E-3 5.934E-3 2 5
13 27501351 Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Pubmed 3.513E-6 6.356E-4 5.348E-3 8.898E-3 2 6
14 11409905 Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system. Pubmed 3.513E-6 6.356E-4 5.348E-3 8.898E-3 2 6
15 24482476 Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Pubmed 2.452E-5 1.277E-3 1.074E-2
6.212E-2
 2 15
16 18971422 Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Pubmed 5.384E-5 1.277E-3 1.074E-2
1.364E-1
 2 22
17 22988430 A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Pubmed 5.895E-5 1.277E-3 1.074E-2
1.493E-1
 2 23
18 9275178 Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. Pubmed 6.986E-5 1.277E-3 1.074E-2
1.770E-1
 2 25
19 22118674 Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Pubmed 1.011E-4 1.277E-3 1.074E-2
2.562E-1
 2 30
20 19343046 Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Pubmed 1.160E-4 1.277E-3 1.074E-2
2.938E-1
 3 193
21 22626734 A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. Pubmed 1.462E-4 1.277E-3 1.074E-2
3.704E-1
 2 36
22 19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions. Pubmed 1.631E-4 1.277E-3 1.074E-2
4.131E-1
 2 38
23 20381070 Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. Pubmed 1.808E-4 1.277E-3 1.074E-2
4.580E-1
 2 40
24 25681447 SPG7 mutations are a common cause of undiagnosed ataxia. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
25 16759795 p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
26 16987144 Effect of over-expression of neuropathy target esterase on mammalian cell proliferation. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
27 26941382 ALDH2 Glu504Lys Confers Susceptibility to Schizophrenia and Impacts Hippocampal-Prefrontal Functional Connectivity. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
28 25832430 Seipin mutation at glycosylation sites activates autophagy in transfected cells via abnormal large lipid droplets generation. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
29 25759460 East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
30 26459808 VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
31 26899237 Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
32 27488451 Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
33 28847041 Age of Drinking Initiation as a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
34 21114754 Alcohol ingestion and colorectal neoplasia: a meta-analysis based on a Mendelian randomization approach. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
35 23418070 Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
36 11441142 Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
37 2558488 Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
38 22393400 Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
39 25863102 [Study on the association of USP8 gene polymorphisms with male infertility in ethnic Han Chinese from Sichuan]. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
40 29892902 Wide phenotypic spectrum in axonal Charcot-Marie-Tooth neuropathy type 2 patients with KIF5A mutations. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
41 18500496 A novel KIF5A/SPG10 mutation in spastic paraplegia associated with axonal neuropathy. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
42 12123845 Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
43 15094302 Lysophospholipase inhibition by organophosphorus toxicants. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
44 24636131 N-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
45 24998256 Impact of chronic low to moderate alcohol consumption on blood lipid and heart energy profile in acetaldehyde dehydrogenase 2-deficient mice. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
46 25041530 Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
47 27866050 Boucher Neuhäuser Syndrome - A rare cause of inherited hypogonadotropic hypogonadism. A case of two adult siblings with two novel mutations in PNPLA6. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
48 26578638 The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
49 9765594 Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
50 22533991 Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells. Pubmed 4.975E-4 1.277E-3 1.074E-2
1.000E0
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 19 input genes in category / 934 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AP4B1 AP4B1 interactions 1.720E-7 1.607E-4 1.192E-3 1.607E-4 3 11
2 int:AP4E1 AP4E1 interactions 1.005E-6 4.692E-4 3.480E-3 9.384E-4 3 19
3 int:AP4S1 AP4S1 interactions 1.593E-6 4.961E-4 3.680E-3 1.488E-3 3 22
4 int:AP4M1 AP4M1 interactions 1.010E-5 2.358E-3 1.749E-2 9.432E-3 3 40
5 int:SUV39H2 SUV39H2 interactions 4.390E-5 8.200E-3
6.082E-2
 4.100E-2 3 65
6 int:GABRG2 GABRG2 interactions 1.653E-4 2.573E-2
1.908E-1
1.544E-1
 2 18
7 int:POM121C POM121C interactions 2.264E-4 3.021E-2
2.241E-1
2.115E-1
 2 21
8 int:TRIM54 TRIM54 interactions 3.598E-4 3.629E-2
2.692E-1
3.360E-1
 3 132
9 int:USP21 USP21 interactions 3.843E-4 3.629E-2
2.692E-1
3.589E-1
 3 135
10 int:CHMP1B CHMP1B interactions 4.057E-4 3.629E-2
2.692E-1
3.789E-1
 2 28
11 int:TEPSIN TEPSIN interactions 4.663E-4 3.629E-2
2.692E-1
4.355E-1
 2 30
12 int:PLA2G2A PLA2G2A interactions 4.663E-4 3.629E-2
2.692E-1
4.355E-1
 2 30
Show 7 more annotations

10: Cytoband [Display Chart] 19 input genes in category / 17 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q21.2 15q21.2 1.146E-4 1.948E-3 6.699E-3 1.948E-3 2 29
2 11q13 11q13 1.924E-3 1.635E-2
5.624E-2
 3.270E-2 2 119
3 15q21-q22 15q21-q22 3.285E-3 1.861E-2
6.402E-2
5.584E-2
 1 6
4 3q12.2 3q12.2 4.923E-3 2.092E-2
7.197E-2
8.370E-2
 1 9
5 12q24.2 12q24.2 8.737E-3 2.970E-2
1.022E-1
1.485E-1
 1 16
6 5p15.2 5p15.2 1.578E-2 4.363E-2
1.501E-1
2.683E-1
 1 29
7 4p14 4p14 2.332E-2 4.363E-2
1.501E-1
3.964E-1
 1 43
8 3p21.1 3p21.1 2.439E-2 4.363E-2
1.501E-1
4.146E-1
 1 45
9 1p13.2 1p13.2 2.546E-2 4.363E-2
1.501E-1
4.328E-1
 1 47
10 11q13.2 11q13.2 2.706E-2 4.363E-2
1.501E-1
4.601E-1
 1 50
11 16q24.3 16q24.3 3.026E-2 4.363E-2
1.501E-1
5.145E-1
 1 56
12 17p13.2 17p13.2 3.080E-2 4.363E-2
1.501E-1
5.235E-1
 1 57
13 12q13.13 12q13.13 3.769E-2 4.929E-2
1.695E-1
6.408E-1
 1 70
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 15 input genes in category / 146 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$ERR1 Q2 V$ERR1 Q2 2.351E-4 3.432E-2
1.910E-1
 3.432E-2 4 210

12: Gene Family [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 398 Aldehyde dehydrogenases genenames.org 4.626E-5 4.626E-4 1.355E-3 4.626E-4 2 19
2 622 Kinesins|Protein phosphatase 1 regulatory subunits genenames.org 2.778E-4 1.389E-3 4.068E-3 2.778E-3 2 46
3 998 INO80 complex |Ubiquitin C-terminal hydrolases genenames.org 2.197E-3 7.323E-3 2.145E-2 2.197E-2 1 4
4 466 Patatin like phospholipase domain containing genenames.org 5.484E-3 1.252E-2 3.666E-2
5.484E-2
 1 10
5 975 EF-hand domain containing|Calpains genenames.org 8.216E-3 1.252E-2 3.666E-2
8.216E-2
 1 15
6 587 Chaperonins genenames.org 8.216E-3 1.252E-2 3.666E-2
8.216E-2
 1 15
7 672 Parkinson disease associated genes|Ubiquitin C-terminal hydrolases genenames.org 8.762E-3 1.252E-2 3.666E-2
8.762E-2
 1 16
8 413 AAA ATPases genenames.org 2.876E-2 3.374E-2
9.882E-2
2.876E-1
 1 53
9 366 Ubiquitin specific peptidases genenames.org 3.036E-2 3.374E-2
9.882E-2
3.036E-1
 1 56
Show 4 more annotations

13: Coexpression [Display Chart] 19 input genes in category / 1764 annotations before applied cutoff / 23137 genes in category

No results to display

14: Coexpression Atlas [Display Chart] 19 input genes in category / 1217 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 15 input genes in category / 72 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 19 input genes in category / 548 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-503-5p:TargetScan hsa-miR-503-5p TargetScan 2.365E-5 1.296E-2
8.922E-2
 1.296E-2 3 213
2 hsa-miR-4258:mirSVR highEffct hsa-miR-4258:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.228E-4 2.802E-2
1.929E-1
6.727E-2
 2 62
3 hsa-miR-151a-5p:Functional MTI Functional MTI miRTarbase 1.995E-4 2.802E-2
1.929E-1
1.093E-1
 2 79
4 hsa-miR-1224-3p:mirSVR highEffct hsa-miR-1224-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.546E-4 2.802E-2
1.929E-1
1.395E-1
 3 476
5 hsa-miR-6128:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.068E-4 2.802E-2
1.929E-1
1.681E-1
 2 98
6 hsa-miR-8066:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.068E-4 2.802E-2
1.929E-1
1.681E-1
 2 98
7 hsa-miR-6165:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.977E-4 4.203E-2
2.893E-1
3.276E-1
 2 137
8 hsa-miR-1469:mirSVR lowEffct hsa-miR-1469:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.599E-4 4.203E-2
2.893E-1
3.616E-1
 2 144
9 hsa-miR-6847-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.346E-4 4.203E-2
2.893E-1
4.026E-1
 2 152
10 hsa-miR-642:PITA hsa-miR-642:PITA TOP PITA 8.852E-4 4.203E-2
2.893E-1
4.851E-1
 2 167
11 hsa-miR-6514-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.004E-3 4.203E-2
2.893E-1
5.503E-1
 2 178
12 hsa-miR-6811-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.049E-3 4.203E-2
2.893E-1
5.751E-1
 2 182
13 hsa-miR-214-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.119E-3 4.203E-2
2.893E-1
6.131E-1
 2 188
14 hsa-miR-1343-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.178E-3 4.203E-2
2.893E-1
6.458E-1
 2 193
15 hsa-miR-939-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.252E-3 4.203E-2
2.893E-1
6.860E-1
 2 199
16 hsa-miR-640:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.289E-3 4.203E-2
2.893E-1
7.066E-1
 2 202
17 hsa-miR-140-3p:Functional MTI Functional MTI miRTarbase 1.581E-3 4.203E-2
2.893E-1
8.663E-1
 2 224
18 hsa-miR-643:PITA hsa-miR-643:PITA TOP PITA 1.595E-3 4.203E-2
2.893E-1
8.739E-1
 2 225
19 hsa-miR-764:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.087E-3 4.203E-2
2.893E-1
1.000E0
 2 258
20 hsa-miR-302f:PITA hsa-miR-302f:PITA TOP PITA 2.332E-3 4.203E-2
2.893E-1
1.000E0
 2 273
21 hsa-miR-1249-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.349E-3 4.203E-2
2.893E-1
1.000E0
 2 274
22 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 2.382E-3 4.203E-2
2.893E-1
1.000E0
 2 276
23 hsa-miR-3934-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.399E-3 4.203E-2
2.893E-1
1.000E0
 2 277
24 hsa-miR-6797-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.399E-3 4.203E-2
2.893E-1
1.000E0
 2 277
25 hsa-miR-6790-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.485E-3 4.203E-2
2.893E-1
1.000E0
 2 282
26 hsa-miR-4756-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.555E-3 4.203E-2
2.893E-1
1.000E0
 2 286
27 hsa-miR-6821-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.555E-3 4.203E-2
2.893E-1
1.000E0
 2 286
28 hsa-miR-1321:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 4.203E-2
2.893E-1
1.000E0
 2 287
29 hsa-miR-455-3p.1:TargetScan hsa-miR-455-3p.1 TargetScan 2.572E-3 4.203E-2
2.893E-1
1.000E0
 2 287
30 hsa-miR-4779:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 4.203E-2
2.893E-1
1.000E0
 2 287
31 hsa-miR-4739:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.625E-3 4.203E-2
2.893E-1
1.000E0
 2 290
32 hsa-miR-6130:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.823E-3 4.203E-2
2.893E-1
1.000E0
 2 301
33 hsa-miR-4419a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.823E-3 4.203E-2
2.893E-1
1.000E0
 2 301
34 hsa-miR-6129:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.842E-3 4.203E-2
2.893E-1
1.000E0
 2 302
35 hsa-miR-4510:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.860E-3 4.203E-2
2.893E-1
1.000E0
 2 303
36 hsa-miR-6127:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.897E-3 4.203E-2
2.893E-1
1.000E0
 2 305
37 hsa-miR-6133:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.897E-3 4.203E-2
2.893E-1
1.000E0
 2 305
38 hsa-miR-512-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.972E-3 4.203E-2
2.893E-1
1.000E0
 2 309
39 hsa-miR-125a-3p:Functional MTI Functional MTI miRTarbase 2.991E-3 4.203E-2
2.893E-1
1.000E0
 2 310
40 hsa-miR-139-5p:TargetScan hsa-miR-139-5p TargetScan 3.086E-3 4.228E-2
2.910E-1
1.000E0
 2 315
41 hsa-miR-140-3p:PITA hsa-miR-140-3p:PITA TOP PITA 3.359E-3 4.490E-2
3.091E-1
1.000E0
 2 329
42 hsa-miR-574-3p:mirSVR lowEffct hsa-miR-574-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.706E-3 4.623E-2
3.183E-1
1.000E0
 2 346
43 hsa-miR-324-5p:mirSVR highEffct hsa-miR-324-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 3.832E-3 4.623E-2
3.183E-1
1.000E0
 2 352
44 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 3.854E-3 4.623E-2
3.183E-1
1.000E0
 2 353
45 hsa-miR-6869-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.938E-3 4.623E-2
3.183E-1
1.000E0
 1 15
46 hsa-miR-548al:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.200E-3 4.623E-2
3.183E-1
1.000E0
 1 16
47 hsa-miR-5089-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.268E-3 4.623E-2
3.183E-1
1.000E0
 2 372
48 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 4.425E-3 4.623E-2
3.183E-1
1.000E0
 2 379
49 hsa-miR-3177-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.462E-3 4.623E-2
3.183E-1
1.000E0
 1 17
50 hsa-miR-378a-5p:Functional MTI Functional MTI miRTarbase 4.585E-3 4.623E-2
3.183E-1
1.000E0
 2 386
Show 45 more annotations

17: Drug [Display Chart] 19 input genes in category / 4962 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 446 DN 15d-PGJ2; Down 200; 10uM; PC3; HG-U133A Broad Institute CMAP Down 1.699E-5 3.235E-2
2.939E-1
8.431E-2
 4 192
2 1392 DN Pindolol [13523-86-9]; Down 200; 16.2uM; HL60; HG-U133A Broad Institute CMAP Down 1.880E-5 3.235E-2
2.939E-1
9.327E-2
 4 197
3 1319 DN Cefotetan [69712-56-7]; Down 200; 7uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.956E-5 3.235E-2
2.939E-1
9.704E-2
 4 199
4 CID000031782 AC1L1MBN Stitch 3.996E-5 4.300E-2
3.907E-1
1.983E-1
 3 81
5 CID000102399 AC1L2SPS Stitch 5.086E-5 4.300E-2
3.907E-1
2.523E-1
 2 13
6 ctd:D010664 Phenylmethylsulfonyl Fluoride CTD 6.839E-5 4.300E-2
3.907E-1
3.394E-1
 2 15
7 ctd:C025541 tri-o-cresyl phosphate CTD 7.812E-5 4.300E-2
3.907E-1
3.876E-1
 2 16
8 CID000000335 o-cresol Stitch 1.112E-4 4.300E-2
3.907E-1
5.516E-1
 2 19
9 ctd:C014655 methamidophos CTD 1.234E-4 4.300E-2
3.907E-1
6.126E-1
 2 20
10 ctd:D007531 Isoflurophate CTD 1.790E-4 4.300E-2
3.907E-1
8.881E-1
 2 24
11 CID000064956 beta-aminoisobutyric acid Stitch 1.790E-4 4.300E-2
3.907E-1
8.881E-1
 2 24
12 CID000016653 molinate Stitch 1.944E-4 4.300E-2
3.907E-1
9.648E-1
 2 25
13 CID000445014 1-AR Stitch 1.944E-4 4.300E-2
3.907E-1
9.648E-1
 2 25
14 CID000200882 AC1L45AJ Stitch 3.620E-4 4.300E-2
3.907E-1
1.000E0
 2 34
15 4569 UP Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.209E-4 4.300E-2
3.907E-1
1.000E0
 3 193
16 334 UP 6-mercaptopurine monohydrate; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Up 5.288E-4 4.300E-2
3.907E-1
1.000E0
 3 194
17 2467 DN Omeprazole [73590-58-6]; Down 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.288E-4 4.300E-2
3.907E-1
1.000E0
 3 194
18 4951 UP Omeprazole [73590-58-6]; Up 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.288E-4 4.300E-2
3.907E-1
1.000E0
 3 194
19 4163 DN Trimipramine maleate salt [521-78-8]; Down 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.288E-4 4.300E-2
3.907E-1
1.000E0
 3 194
20 1341 UP Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.288E-4 4.300E-2
3.907E-1
1.000E0
 3 194
21 1731 UP Cyclizine hydrochloride [303-25-3]; Up 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP Up 5.368E-4 4.300E-2
3.907E-1
1.000E0
 3 195
22 3669 DN Metaraminol bitartrate [33402-03-8]; Down 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.368E-4 4.300E-2
3.907E-1
1.000E0
 3 195
23 5240 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.368E-4 4.300E-2
3.907E-1
1.000E0
 3 195
24 5269 DN Flurbiprofen [5104-49-4]; Down 200; 16.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.368E-4 4.300E-2
3.907E-1
1.000E0
 3 195
25 5241 DN haloperidol; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.368E-4 4.300E-2
3.907E-1
1.000E0
 3 195
26 1292 UP Clebopride maleate [84370-95-6]; Up 200; 8.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.448E-4 4.300E-2
3.907E-1
1.000E0
 3 196
27 2936 DN Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.448E-4 4.300E-2
3.907E-1
1.000E0
 3 196
28 2687 DN LY 294002; Down 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.448E-4 4.300E-2
3.907E-1
1.000E0
 3 196
29 490 DN fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
30 2889 DN Hydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
31 1740 DN Hydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; HL60; HG-U133A Broad Institute CMAP Down 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
32 6475 UP Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
33 1947 UP Hesperetin [520-33-2]; Up 200; 13.2uM; PC3; HG-U133A Broad Institute CMAP Up 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
34 5887 UP Quipazine dimaleate salt [4774-24-7]; Up 200; 9uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
35 2941 DN 3-Acetamidocoumarin [779-30-6]; Down 200; 19.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
36 1717 UP Triflusal [322-79-2]; Up 200; 16.2uM; HL60; HG-U133A Broad Institute CMAP Up 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
37 1828 DN Naproxen [22204-53-1]; Down 200; 17.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
38 3242 UP Carcinine [56897-53-1]; Up 200; 22uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.530E-4 4.300E-2
3.907E-1
1.000E0
 3 197
39 CID000000134 gamma-butyrobetaine Stitch 5.534E-4 4.300E-2
3.907E-1
1.000E0
 2 42
40 6176 DN chlorpromazine hydrochloride; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
41 5628 UP Bephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
42 504 DN troglitazone; Down 200; 10uM; SKMEL5; HG-U133A Broad Institute CMAP Down 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
43 6226 UP Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
44 168 UP sulindac; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
45 6467 UP Altretamine [654-05-6]; Up 200; 19uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
46 2128 UP Meclofenamic acid sodium salt monohydrate [6385-02-0]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
47 2453 UP Fluoxetine hydrochloride [59333-67-4]; Up 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
48 2030 UP Ampicillin trihydrate [7177-48-2]; Up 200; 10uM; HL60; HG-U133A Broad Institute CMAP Up 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
49 1326 DN Muramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
50 2995 DN Theobromine [83-67-0]; Down 200; 22.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.612E-4 4.300E-2
3.907E-1
1.000E0
 3 198
Show 45 more annotations

18: Disease [Display Chart] 19 input genes in category / 756 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0034935 Babinski Reflex DisGeNET Curated 7.494E-23 5.666E-20 4.083E-19 5.666E-20 12 100
2 C0037772 Spastic Paraplegia DisGeNET Curated 6.827E-21 2.581E-18 1.860E-17 5.161E-18 11 91
3 C0151889 Hyperreflexia DisGeNET Curated 8.709E-17 2.195E-14 1.581E-13 6.584E-14 11 209
4 C0037773 Spastic Paraplegia, Hereditary DisGeNET Curated 9.883E-9 1.781E-6 1.284E-5 7.472E-6 5 65
5 C0231687 Spastic gait DisGeNET Curated 1.178E-8 1.781E-6 1.284E-5 8.907E-6 4 23
6 C0427068 Monoparesis - leg DisGeNET Curated 2.328E-8 2.934E-6 2.114E-5 1.760E-5 4 27
7 C1836296 Weakness of lower limb DisGeNET Curated 5.405E-8 5.837E-6 4.206E-5 4.086E-5 4 33
8 C0034152 Henoch-Schoenlein Purpura DisGeNET Curated 8.783E-8 8.300E-6 5.981E-5 6.640E-5 5 100
9 C4020873 Infratentorial atrophy DisGeNET Curated 1.019E-7 8.560E-6 6.169E-5 7.704E-5 5 103
10 C0037771 Paraparesis, Spastic DisGeNET Curated 3.004E-7 2.209E-5 1.592E-4 2.271E-4 4 50
11 C0740279 Atrophy of cerebellum DisGeNET Curated 3.268E-7 2.209E-5 1.592E-4 2.470E-4 5 130
12 C1848736 Distal amyotrophy DisGeNET Curated 3.526E-7 2.209E-5 1.592E-4 2.665E-4 4 52
13 C1849134 Decreased lower limb vibratory sense DisGeNET Curated 3.879E-7 2.209E-5 1.592E-4 2.933E-4 3 13
14 C0262404 Cerebellar degeneration DisGeNET Curated 4.091E-7 2.209E-5 1.592E-4 3.093E-4 5 136
15 C1864985 Progressive disorder DisGeNET Curated 5.251E-7 2.647E-5 1.907E-4 3.970E-4 5 143
16 C1849156 Spastic Ataxia DisGeNET Curated 1.103E-6 5.210E-5 3.755E-4 8.337E-4 3 18
17 C1855346 MAST SYNDROME DisGeNET Curated 1.302E-6 5.792E-5 4.174E-4 9.846E-4 2 2
18 C1854494 Slow progression DisGeNET Curated 3.235E-6 1.359E-4 9.791E-4 2.446E-3 4 90
19 C1608410 Head titubation DisGeNET Curated 3.905E-6 1.554E-4 1.120E-3 2.952E-3 2 3
20 C0270914 Hereditary Motor and Sensory-Neuropathy Type II DisGeNET Curated 5.438E-6 2.056E-4 1.481E-3 4.111E-3 3 30
21 C0443306 Spastic DisGeNET BeFree 6.016E-6 2.166E-4 1.561E-3 4.548E-3 3 31
22 C0235946 Cerebral atrophy DisGeNET Curated 8.504E-6 2.922E-4 2.106E-3 6.429E-3 5 252
23 C0007758 Cerebellar Ataxia DisGeNET Curated 9.191E-6 3.021E-4 2.177E-3 6.949E-3 6 453
24 C1839758 Narrow forehead DisGeNET Curated 1.035E-5 3.261E-4 2.350E-3 7.827E-3 3 37
25 C0442874 Neuropathy DisGeNET Curated 1.167E-5 3.529E-4 2.543E-3 8.823E-3 5 269
26 C0426970 Spastic Quadriplegia DisGeNET Curated 1.216E-5 3.536E-4 2.548E-3 9.193E-3 3 39
27 C1389102 Atrophic spinal cord DisGeNET Curated 1.300E-5 3.639E-4 2.622E-3 9.826E-3 2 5
28 C2752013 Prenatal onset DisGeNET Curated 1.818E-5 4.909E-4 3.537E-3 1.374E-2 4 139
29 C0393555 Pure hereditary spastic paraplegia DisGeNET BeFree 1.948E-5 5.079E-4 3.660E-3 1.473E-2 2 6
30 C0240543 Bulbous nose DisGeNET Curated 2.286E-5 5.401E-4 3.892E-3 1.728E-2 3 48
31 C1855751 Bulbous nasal tip DisGeNET Curated 2.286E-5 5.401E-4 3.892E-3 1.728E-2 3 48
32 C1834118 Potato nose DisGeNET Curated 2.286E-5 5.401E-4 3.892E-3 1.728E-2 3 48
33 C1847584 Distal sensory impairment DisGeNET Curated 2.912E-5 6.672E-4 4.808E-3 2.202E-2 3 52
34 C1861324 Short philtrum DisGeNET Curated 3.085E-5 6.859E-4 4.943E-3 2.332E-2 3 53
35 C0751837 Gait Ataxia DisGeNET Curated 4.711E-5 1.018E-3 7.333E-3 3.562E-2 3 61
36 C0270921 Axonal neuropathy DisGeNET Curated 4.947E-5 1.039E-3 7.486E-3 3.740E-2 3 62
37 C1271100 Lower limb spasticity DisGeNET Curated 5.828E-5 1.187E-3 8.556E-3 4.406E-2 2 10
38 C2267233 Neonatal Hypotonia DisGeNET Curated 5.968E-5 1.187E-3 8.556E-3 4.512E-2 3 66
39 C0004134 Ataxia DisGeNET Curated 7.694E-5 1.492E-3 1.075E-2
5.817E-2
 4 201
40 C0024433 Macrostomia DisGeNET Curated 8.069E-5 1.525E-3 1.099E-2
6.101E-2
 3 73
41 C0151313 Sensory neuropathy DisGeNET Curated 9.463E-5 1.745E-3 1.257E-2
7.154E-2
 3 77
42 C3544092 Urgency frequency syndrome DisGeNET Curated 1.175E-4 2.116E-3 1.524E-2
8.885E-2
 2 14
43 C0728829 Congenital pes cavus DisGeNET Curated 1.456E-4 2.560E-3 1.845E-2
1.101E-1
 3 89
44 C1843663 Sphincter disturbances DisGeNET Curated 1.548E-4 2.613E-3 1.883E-2
1.170E-1
 2 16
45 C4024896 Motor neuron atrophy DisGeNET BeFree 1.555E-4 2.613E-3 1.883E-2
1.176E-1
 3 91
46 C4020898 Overactive bladder syndrome DisGeNET Curated 1.753E-4 2.856E-3 2.058E-2
1.325E-1
 2 17
47 C0029124 Optic Atrophy DisGeNET Curated 1.786E-4 2.856E-3 2.058E-2
1.350E-1
 4 250
48 C0026838 Muscle Spasticity DisGeNET Curated 1.814E-4 2.856E-3 2.058E-2
1.371E-1
 4 251
49 C0085606 Urgency of micturition DisGeNET Curated 1.971E-4 3.040E-3 2.191E-2
1.490E-1
 2 18
50 C0031117 Peripheral Neuropathy DisGeNET Curated 2.644E-4 3.856E-3 2.778E-2
1.999E-1
 4 277
Show 45 more annotations