Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc59_9, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 9 input genes in category / 47 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070888 E-box binding 1.297E-9 6.098E-8 2.706E-7 6.098E-8 4 35
2 GO:0001046 core promoter sequence-specific DNA binding 1.864E-5 4.381E-4 1.944E-3 8.761E-4 3 115
3 GO:0001047 core promoter binding 5.385E-5 8.437E-4 3.744E-3 2.531E-3 3 164
4 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 5.711E-4 5.036E-3 2.235E-2 2.684E-2 3 365
5 GO:0031490 chromatin DNA binding 7.230E-4 5.036E-3 2.235E-2 3.398E-2 2 85
6 GO:0003904 deoxyribodipyrimidine photo-lyase activity 9.644E-4 5.036E-3 2.235E-2 4.533E-2 1 2
7 GO:0003914 DNA (6-4) photolyase activity 9.644E-4 5.036E-3 2.235E-2 4.533E-2 1 2
8 GO:0009882 blue light photoreceptor activity 9.644E-4 5.036E-3 2.235E-2 4.533E-2 1 2
9 GO:0003913 DNA photolyase activity 9.644E-4 5.036E-3 2.235E-2 4.533E-2 1 2
10 GO:0043130 ubiquitin binding 1.163E-3 5.468E-3 2.427E-2
5.468E-2
 2 108
11 GO:0032182 ubiquitin-like protein binding 1.603E-3 6.851E-3 3.040E-2
7.536E-2
 2 127
12 GO:0017162 aryl hydrocarbon receptor binding 1.928E-3 7.551E-3 3.351E-2
9.061E-2
 1 4
13 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 6.478E-3 2.167E-2
9.618E-2
3.045E-1
 2 259
14 GO:0031625 ubiquitin protein ligase binding 7.173E-3 2.167E-2
9.618E-2
3.371E-1
 2 273
15 GO:0009881 photoreceptor activity 7.213E-3 2.167E-2
9.618E-2
3.390E-1
 1 15
16 GO:0044389 ubiquitin-like protein ligase binding 7.378E-3 2.167E-2
9.618E-2
3.468E-1
 2 277
17 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.202E-2 3.324E-2
1.475E-1
5.650E-1
 2 357
18 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 1.348E-2 3.476E-2
1.543E-1
6.334E-1
 2 379
19 GO:0043425 bHLH transcription factor binding 1.438E-2 3.476E-2
1.543E-1
6.758E-1
 1 30
20 GO:0000987 proximal promoter sequence-specific DNA binding 1.479E-2 3.476E-2
1.543E-1
6.952E-1
 2 398
21 GO:0051879 Hsp90 protein binding 1.723E-2 3.857E-2
1.712E-1
8.099E-1
 1 36
Show 16 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 317 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042752 regulation of circadian rhythm 1.014E-14 3.215E-12 2.037E-11 3.215E-12 7 115
2 GO:0032922 circadian regulation of gene expression 8.851E-14 1.403E-11 8.891E-11 2.806E-11 6 62
3 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway 3.771E-13 3.984E-11 2.525E-10 1.195E-10 4 6
4 GO:0007623 circadian rhythm 8.468E-13 6.711E-11 4.253E-10 2.684E-10 7 214
5 GO:2000322 regulation of glucocorticoid receptor signaling pathway 1.243E-11 7.879E-10 4.993E-9 3.939E-9 4 12
6 GO:0048511 rhythmic process 3.724E-11 1.967E-9 1.247E-8 1.180E-8 7 366
7 GO:0042921 glucocorticoid receptor signaling pathway 1.214E-10 5.499E-9 3.485E-8 3.849E-8 4 20
8 GO:0031958 corticosteroid receptor signaling pathway 2.218E-10 8.788E-9 5.570E-8 7.031E-8 4 23
9 GO:0009649 entrainment of circadian clock 3.742E-10 1.318E-8 8.353E-8 1.186E-7 4 26
10 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 1.023E-9 3.242E-8 2.055E-7 3.242E-7 4 33
11 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 2.550E-8 7.348E-7 4.657E-6 8.083E-6 4 72
12 GO:0009648 photoperiodism 1.572E-7 4.152E-6 2.631E-5 4.982E-5 3 24
13 GO:0042634 regulation of hair cycle 1.786E-7 4.354E-6 2.759E-5 5.660E-5 3 25
14 GO:0030518 intracellular steroid hormone receptor signaling pathway 3.333E-7 7.546E-6 4.783E-5 1.056E-4 4 136
15 GO:0043401 steroid hormone mediated signaling pathway 1.244E-6 2.467E-5 1.563E-4 3.945E-4 4 189
16 GO:0097167 circadian regulation of translation 1.245E-6 2.467E-5 1.563E-4 3.947E-4 2 4
17 GO:0009755 hormone-mediated signaling pathway 2.674E-6 4.986E-5 3.160E-4 8.476E-4 4 229
18 GO:2000074 regulation of type B pancreatic cell development 5.804E-6 1.022E-4 6.479E-4 1.840E-3 2 8
19 GO:0071383 cellular response to steroid hormone stimulus 6.824E-6 1.139E-4 7.216E-4 2.163E-3 4 290
20 GO:0030522 intracellular receptor signaling pathway 7.701E-6 1.209E-4 7.665E-4 2.441E-3 4 299
21 GO:0046883 regulation of hormone secretion 8.012E-6 1.209E-4 7.665E-4 2.540E-3 4 302
22 GO:0051775 response to redox state 1.367E-5 1.969E-4 1.248E-3 4.333E-3 2 12
23 GO:0046879 hormone secretion 1.551E-5 2.137E-4 1.354E-3 4.916E-3 4 357
24 GO:0009914 hormone transport 1.785E-5 2.358E-4 1.494E-3 5.659E-3 4 370
25 GO:0042303 molting cycle 2.131E-5 2.598E-4 1.646E-3 6.754E-3 3 120
26 GO:0042633 hair cycle 2.131E-5 2.598E-4 1.646E-3 6.754E-3 3 120
27 GO:0042754 negative regulation of circadian rhythm 3.535E-5 3.864E-4 2.449E-3 1.121E-2 2 19
28 GO:0043153 entrainment of circadian clock by photoperiod 3.535E-5 3.864E-4 2.449E-3 1.121E-2 2 19
29 GO:0003323 type B pancreatic cell development 3.535E-5 3.864E-4 2.449E-3 1.121E-2 2 19
30 GO:0070932 histone H3 deacetylation 4.772E-5 5.042E-4 3.196E-3 1.513E-2 2 22
31 GO:0023061 signal release 5.721E-5 5.850E-4 3.708E-3 1.814E-2 4 498
32 GO:0003309 type B pancreatic cell differentiation 6.193E-5 6.135E-4 3.888E-3 1.963E-2 2 25
33 GO:0002068 glandular epithelial cell development 6.707E-5 6.443E-4 4.083E-3 2.126E-2 2 26
34 GO:0042753 positive regulation of circadian rhythm 7.242E-5 6.752E-4 4.279E-3 2.296E-2 2 27
35 GO:0035883 enteroendocrine cell differentiation 7.797E-5 7.062E-4 4.475E-3 2.472E-2 2 28
36 GO:0050796 regulation of insulin secretion 9.344E-5 8.228E-4 5.215E-3 2.962E-2 3 197
37 GO:0030073 insulin secretion 1.498E-4 1.283E-3 8.131E-3 4.747E-2 3 231
38 GO:0090276 regulation of peptide hormone secretion 1.575E-4 1.314E-3 8.329E-3 4.994E-2 3 235
39 GO:0002791 regulation of peptide secretion 1.677E-4 1.363E-3 8.637E-3
5.315E-2
 3 240
40 GO:0031018 endocrine pancreas development 2.615E-4 2.072E-3 1.313E-2
8.289E-2
 2 51
41 GO:0030072 peptide hormone secretion 2.697E-4 2.085E-3 1.322E-2
8.550E-2
 3 282
42 GO:0002067 glandular epithelial cell differentiation 2.825E-4 2.110E-3 1.337E-2
8.954E-2
 2 53
43 GO:0090087 regulation of peptide transport 2.899E-4 2.110E-3 1.337E-2
9.190E-2
 3 289
44 GO:0002790 peptide secretion 2.929E-4 2.110E-3 1.337E-2
9.283E-2
 3 290
45 GO:0002066 columnar/cuboidal epithelial cell development 3.867E-4 2.724E-3 1.727E-2
1.226E-1
 2 62
46 GO:0009416 response to light stimulus 4.550E-4 3.135E-3 1.987E-2
1.442E-1
 3 337
47 GO:0015833 peptide transport 5.385E-4 3.632E-3 2.302E-2
1.707E-1
 3 357
48 GO:0042886 amide transport 6.662E-4 4.400E-3 2.788E-2
2.112E-1
 3 384
49 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 7.127E-4 4.611E-3 2.922E-2
2.259E-1
 3 393
50 GO:0016575 histone deacetylation 7.603E-4 4.820E-3 3.055E-2
2.410E-1
 2 87
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 25 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0033391 chromatoid body 1.798E-5 4.495E-4 1.715E-3 4.495E-4 2 14
2 GO:0005667 transcription factor complex 5.499E-4 6.874E-3 2.623E-2 1.375E-2 3 368
3 GO:0036464 cytoplasmic ribonucleoprotein granule 1.971E-3 1.179E-2 4.501E-2 4.927E-2 2 144
4 GO:0035770 ribonucleoprotein granule 2.192E-3 1.179E-2 4.501E-2
5.481E-2
 2 152
5 GO:0005726 perichromatin fibrils 2.359E-3 1.179E-2 4.501E-2
5.897E-2
 1 5
6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex 5.653E-3 2.354E-2
8.984E-2
1.413E-1
 1 12
7 GO:0030877 beta-catenin destruction complex 6.592E-3 2.354E-2
8.984E-2
1.648E-1
 1 14
8 GO:0005849 mRNA cleavage factor complex 8.000E-3 2.500E-2
9.540E-2
2.000E-1
 1 17
9 GO:0016604 nuclear body 1.198E-2 3.328E-2
1.270E-1
2.995E-1
 2 364
Show 4 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 3 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000716 Depressivity 3.303E-3 5.731E-3 1.051E-2 9.910E-3 2 271
2 HP:0006979 Sleep-wake cycle disturbance 3.821E-3 5.731E-3 1.051E-2 1.146E-2 1 9

5: Mouse Phenotype [Display Chart] 8 input genes in category / 571 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020472 arrhythmic circadian behavior persistence 1.512E-17 6.186E-15 4.284E-14 8.632E-15 6 12
2 MP:0020471 abnormal circadian behavior persistence 2.807E-17 6.186E-15 4.284E-14 1.603E-14 6 13
3 MP:0020468 abnormal circadian behavior period 3.250E-17 6.186E-15 4.284E-14 1.856E-14 7 37
4 MP:0020467 abnormal circadian behavior 8.311E-15 1.186E-12 8.216E-12 4.746E-12 7 78
5 MP:0020473 abnormal circadian behavior phase 4.537E-12 5.181E-10 3.588E-9 2.591E-9 5 27
6 MP:0020470 shortened circadian behavior period 5.522E-12 5.255E-10 3.639E-9 3.153E-9 5 28
7 MP:0020478 abnormal circadian sleep/wake cycle 1.022E-11 8.338E-10 5.774E-9 5.837E-9 4 8
8 MP:0020477 abnormal locomotor circadian rhythm 1.459E-10 9.256E-9 6.411E-8 8.331E-8 4 14
9 MP:0020469 prolonged circadian behavior period 1.459E-10 9.256E-9 6.411E-8 8.331E-8 4 14
10 MP:0001501 abnormal sleep pattern 3.606E-10 2.059E-8 1.426E-7 2.059E-7 5 62
11 MP:0011022 abnormal circadian regulation of systemic arterial blood pressure 1.058E-8 5.492E-7 3.803E-6 6.041E-6 3 7
12 MP:0011021 abnormal circadian regulation of heart rate 1.692E-8 7.732E-7 5.355E-6 9.662E-6 3 8
13 MP:0011396 abnormal sleep behavior 1.760E-8 7.732E-7 5.355E-6 1.005E-5 5 133
14 MP:0004988 increased osteoblast cell number 2.151E-8 8.773E-7 6.075E-6 1.228E-5 4 45
15 MP:0010697 abnormal systemic arterial blood pressure regulation 2.537E-8 9.658E-7 6.689E-6 1.449E-5 3 9
16 MP:0010695 abnormal blood pressure regulation 8.626E-8 3.078E-6 2.132E-5 4.925E-5 3 13
17 MP:0011020 abnormal circadian temperature homeostasis 3.430E-7 1.152E-5 7.978E-5 1.958E-4 3 20
18 MP:0004987 abnormal osteoblast cell number 3.637E-7 1.154E-5 7.991E-5 2.077E-4 4 90
19 MP:0009344 abnormal ovulation cycle 4.336E-7 1.238E-5 8.573E-5 2.476E-4 4 94
20 MP:0001927 abnormal estrous cycle 4.336E-7 1.238E-5 8.573E-5 2.476E-4 4 94
21 MP:0009006 prolonged estrous cycle 1.634E-6 4.442E-5 3.076E-4 9.328E-4 3 33
22 MP:0004986 abnormal osteoblast morphology 3.662E-6 9.506E-5 6.583E-4 2.091E-3 4 160
23 MP:0008961 abnormal basal metabolism 4.230E-6 1.050E-4 7.273E-4 2.416E-3 3 45
24 MP:0009661 abnormal pregnancy 4.886E-6 1.162E-4 8.050E-4 2.790E-3 4 172
25 MP:0001792 impaired wound healing 5.833E-6 1.332E-4 9.226E-4 3.330E-3 3 50
26 MP:0001777 abnormal body temperature homeostasis 1.015E-5 2.228E-4 1.543E-3 5.794E-3 3 60
27 MP:0004994 abnormal brain wave pattern 2.072E-5 4.383E-4 3.035E-3 1.183E-2 3 76
28 MP:0020475 delayed circadian behavior phase 2.343E-5 4.614E-4 3.195E-3 1.338E-2 2 10
29 MP:0030438 increased osteoblast proliferation 2.343E-5 4.614E-4 3.195E-3 1.338E-2 2 10
30 MP:0011478 abnormal urine catecholamine level 2.863E-5 5.449E-4 3.774E-3 1.635E-2 2 11
31 MP:0005605 increased bone mass 4.585E-5 8.446E-4 5.849E-3 2.618E-2 3 99
32 MP:0001432 abnormal food preference 6.234E-5 1.112E-3 7.704E-3 3.560E-2 2 16
33 MP:0030437 abnormal osteoblast proliferation 7.942E-5 1.374E-3 9.517E-3 4.535E-2 2 18
34 MP:0002272 abnormal nervous system electrophysiology 8.904E-5 1.466E-3 1.015E-2
5.084E-2
 4 359
35 MP:0005669 increased circulating leptin level 8.984E-5 1.466E-3 1.015E-2
5.130E-2
 3 124
36 MP:0009754 enhanced behavioral response to cocaine 1.553E-4 2.463E-3 1.706E-2
8.868E-2
 2 25
37 MP:0011479 abnormal catecholamine level 1.777E-4 2.658E-3 1.841E-2
1.015E-1
 3 156
38 MP:0008853 decreased abdominal adipose tissue amount 1.816E-4 2.658E-3 1.841E-2
1.037E-1
 2 27
39 MP:0008858 abnormal hair cycle anagen phase 1.816E-4 2.658E-3 1.841E-2
1.037E-1
 2 27
40 MP:0002907 abnormal parturition 2.248E-4 3.208E-3 2.222E-2
1.283E-1
 2 30
41 MP:0008995 early reproductive senescence 2.402E-4 3.345E-3 2.316E-2
1.371E-1
 2 31
42 MP:0009009 absent estrous cycle 2.725E-4 3.705E-3 2.566E-2
1.556E-1
 2 33
43 MP:0005185 decreased circulating progesterone level 3.068E-4 4.065E-3 2.815E-2
1.752E-1
 2 35
44 MP:0002891 increased insulin sensitivity 3.133E-4 4.065E-3 2.815E-2
1.789E-1
 3 189
45 MP:0020158 abnormal behavioral response to cocaine 3.432E-4 4.264E-3 2.953E-2
1.960E-1
 2 37
46 MP:0002998 abnormal bone remodeling 3.435E-4 4.264E-3 2.953E-2
1.961E-1
 3 195
47 MP:0005023 abnormal wound healing 3.866E-4 4.697E-3 3.253E-2
2.208E-1
 3 203
48 MP:0005667 abnormal circulating leptin level 5.230E-4 6.193E-3 4.289E-2
2.986E-1
 3 225
49 MP:0005184 abnormal circulating progesterone level 5.315E-4 6.193E-3 4.289E-2
3.035E-1
 2 46
50 MP:0011384 abnormal progesterone level 6.032E-4 6.888E-3 4.770E-2
3.444E-1
 2 49
Show 45 more annotations

6: Domain [Display Chart] 9 input genes in category / 41 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF08447 PAS 3 Pfam 1.410E-16 2.635E-15 1.134E-14 5.780E-15 6 23
2 IPR013655 PAS fold 3 InterPro 1.410E-16 2.635E-15 1.134E-14 5.780E-15 6 23
3 PS50113 PAC PROSITE 3.214E-16 2.635E-15 1.134E-14 1.318E-14 6 26
4 SM00086 PAC SMART 3.214E-16 2.635E-15 1.134E-14 1.318E-14 6 26
5 IPR001610 PAC InterPro 3.214E-16 2.635E-15 1.134E-14 1.318E-14 6 26
6 SM00091 PAS SMART 1.264E-15 8.637E-15 3.716E-14 5.182E-14 6 32
7 PS50112 PAS PROSITE 1.875E-15 9.611E-15 4.135E-14 7.689E-14 6 34
8 IPR000014 PAS InterPro 1.875E-15 9.611E-15 4.135E-14 7.689E-14 6 34
9 PF12114 Period C Pfam 7.665E-11 3.143E-10 1.352E-9 3.143E-9 3 3
10 IPR022728 Period circadian-like C InterPro 7.665E-11 3.143E-10 1.352E-9 3.143E-9 3 3
11 IPR000700 PAS-assoc C InterPro 2.598E-10 9.683E-10 4.167E-9 1.065E-8 4 24
12 IPR001067 Nuc translocat InterPro 4.288E-9 1.465E-8 6.303E-8 1.758E-7 3 8
13 PF00989 PAS Pfam 1.754E-7 5.136E-7 2.210E-6 7.190E-6 3 25
14 IPR013767 PAS fold InterPro 1.754E-7 5.136E-7 2.210E-6 7.190E-6 3 25
15 4.10.280.10 - Gene3D 1.569E-5 4.288E-5 1.845E-4 6.432E-4 3 109
16 PF00010 HLH Pfam 1.702E-5 4.361E-5 1.877E-4 6.978E-4 3 112
17 SM00353 HLH SMART 1.940E-5 4.405E-5 1.895E-4 7.954E-4 3 117
18 PS50888 BHLH PROSITE 1.990E-5 4.405E-5 1.895E-4 8.160E-4 3 118
19 IPR011598 bHLH dom InterPro 2.041E-5 4.405E-5 1.895E-4 8.369E-4 3 119
20 IPR015524 Per circ prot 3 InterPro 4.804E-4 9.848E-4 4.237E-3 1.970E-2 1 1
21 IPR005101 Cryptochr/Photolyase FAD-bd InterPro 9.606E-4 1.575E-3 6.779E-3 3.938E-2 1 2
22 PS51645 PHR CRY ALPHA BETA PROSITE 9.606E-4 1.575E-3 6.779E-3 3.938E-2 1 2
23 PF03441 FAD binding 7 Pfam 9.606E-4 1.575E-3 6.779E-3 3.938E-2 1 2
24 IPR006050 DNA photolyase N InterPro 9.606E-4 1.575E-3 6.779E-3 3.938E-2 1 2
25 PF00875 DNA photolyase Pfam 9.606E-4 1.575E-3 6.779E-3 3.938E-2 1 2
26 IPR024066 RGS subdom1 InterPro 1.052E-2 1.598E-2
6.875E-2
4.314E-1
 1 22
27 1.10.196.10 - Gene3D 1.052E-2 1.598E-2
6.875E-2
4.314E-1
 1 22
28 SM00315 RGS SMART 1.669E-2 2.346E-2
1.009E-1
6.844E-1
 1 35
29 PF00615 RGS Pfam 1.669E-2 2.346E-2
1.009E-1
6.844E-1
 1 35
30 PS50132 RGS PROSITE 1.717E-2 2.346E-2
1.009E-1
7.038E-1
 1 36
31 IPR016137 RGS InterPro 1.858E-2 2.458E-2
1.058E-1
7.619E-1
 1 39
32 IPR014729 Rossmann-like a/b/a fold InterPro 2.047E-2 2.544E-2
1.094E-1
8.394E-1
 1 43
33 3.40.50.620 - Gene3D 2.047E-2 2.544E-2
1.094E-1
8.394E-1
 1 43
Show 28 more annotations

7: Pathway [Display Chart] 9 input genes in category / 65 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00015 Circadian clock system PantherDB 1.365E-18 8.872E-17 4.223E-16 8.872E-17 6 9
2 83084 Circadian rhythm BioSystems: KEGG 1.191E-14 3.871E-13 1.842E-12 7.742E-13 6 31
3 1269872 BMAL1:CLOCK,NPAS2 activates circadian gene expression BioSystems: REACTOME 1.978E-13 4.286E-12 2.040E-11 1.286E-11 6 48
4 1269871 Circadian Clock BioSystems: REACTOME 2.298E-12 3.734E-11 1.777E-10 1.493E-10 6 71
5 377873 Herpes simplex infection BioSystems: KEGG 8.242E-8 1.026E-6 4.883E-6 5.357E-6 5 185
6 137978 Circadian rhythm pathway BioSystems: Pathway Interaction Database 9.471E-8 1.026E-6 4.883E-6 6.156E-6 3 14
7 698773 Circadian entrainment BioSystems: KEGG 3.609E-5 3.351E-4 1.595E-3 2.346E-3 3 96
8 1269873 RORA activates gene expression BioSystems: REACTOME 1.739E-4 1.413E-3 6.724E-3 1.130E-2 2 28
9 1270030 PPARA activates gene expression BioSystems: REACTOME 3.384E-3 2.194E-2
1.044E-1
2.200E-1
 2 124
10 1270029 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BioSystems: REACTOME 3.547E-3 2.194E-2
1.044E-1
2.305E-1
 2 127
11 469199 Dopaminergic synapse BioSystems: KEGG 3.713E-3 2.194E-2
1.044E-1
2.413E-1
 2 130
12 M12718 Deregulation of CDK5 in Alzheimers Disease MSigDB C2 BIOCARTA (v6.0) 7.926E-3 2.924E-2
1.391E-1
5.152E-1
 1 11
13 1268915 Truncations of AMER1 destabilize the destruction complex BioSystems: REACTOME 1.008E-2 2.924E-2
1.391E-1
6.551E-1
 1 14
14 1268913 AMER1 mutants destabilize the destruction complex BioSystems: REACTOME 1.008E-2 2.924E-2
1.391E-1
6.551E-1
 1 14
15 1268907 truncated APC mutants destabilize the destruction complex BioSystems: REACTOME 1.008E-2 2.924E-2
1.391E-1
6.551E-1
 1 14
16 1268912 AXIN missense mutants destabilize the destruction complex BioSystems: REACTOME 1.008E-2 2.924E-2
1.391E-1
6.551E-1
 1 14
17 1268910 AXIN mutants destabilize the destruction complex, activating WNT signaling BioSystems: REACTOME 1.008E-2 2.924E-2
1.391E-1
6.551E-1
 1 14
18 1268909 APC truncation mutants have impaired AXIN binding BioSystems: REACTOME 1.008E-2 2.924E-2
1.391E-1
6.551E-1
 1 14
19 1268917 S45 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 1.079E-2 2.924E-2
1.391E-1
7.017E-1
 1 15
20 1268919 S37 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 1.079E-2 2.924E-2
1.391E-1
7.017E-1
 1 15
21 1268920 S33 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 1.079E-2 2.924E-2
1.391E-1
7.017E-1
 1 15
22 1268916 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex BioSystems: REACTOME 1.079E-2 2.924E-2
1.391E-1
7.017E-1
 1 15
23 1268921 Misspliced GSK3beta mutants stabilize beta-catenin BioSystems: REACTOME 1.079E-2 2.924E-2
1.391E-1
7.017E-1
 1 15
24 1268918 T41 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 1.079E-2 2.924E-2
1.391E-1
7.017E-1
 1 15
25 1269597 Beta-catenin phosphorylation cascade BioSystems: REACTOME 1.223E-2 3.170E-2
1.509E-1
7.947E-1
 1 17
26 1269642 Activation of SMO BioSystems: REACTOME 1.294E-2 3.170E-2
1.509E-1
8.412E-1
 1 18
27 1270010 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 1.348E-2 3.170E-2
1.509E-1
8.760E-1
 2 253
28 P00025 Hedgehog signaling pathway PantherDB 1.366E-2 3.170E-2
1.509E-1
8.876E-1
 1 19
29 M5202 Hypoxia and p53 in the Cardiovascular system MSigDB C2 BIOCARTA (v6.0) 1.651E-2 3.700E-2
1.761E-1
1.000E0
 1 23
30 M16517 WNT Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.864E-2 4.040E-2
1.923E-1
1.000E0
 1 26
31 169354 Noncanonical Wnt signaling pathway BioSystems: Pathway Interaction Database 2.149E-2 4.505E-2
2.144E-1
1.000E0
 1 30
32 138032 Canonical Wnt signaling pathway BioSystems: Pathway Interaction Database 2.219E-2 4.508E-2
2.146E-1
1.000E0
 1 31
33 1269601 Disassembly of the destruction complex and recruitment of AXIN to the membrane BioSystems: REACTOME 2.290E-2 4.511E-2
2.147E-1
1.000E0
 1 32
34 M17761 Wnt/beta-catenin Pathway MSigDB C2 BIOCARTA (v6.0) 2.432E-2 4.648E-2
2.212E-1
1.000E0
 1 34
35 1268906 Signaling by WNT in cancer BioSystems: REACTOME 2.503E-2 4.648E-2
2.212E-1
1.000E0
 1 35
Show 30 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 1853 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19693801 PER2 variantion is associated with depression vulnerability. Pubmed 1.751E-23 3.245E-20 2.629E-19 3.245E-20 7 16
2 20174623 Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. Pubmed 4.871E-23 4.513E-20 3.656E-19 9.026E-20 7 18
3 20072116 Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Pubmed 7.712E-23 4.764E-20 3.859E-19 1.429E-19 7 19
4 23546644 Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock. Pubmed 1.364E-22 6.321E-20 5.121E-19 2.528E-19 6 7
5 14701732 Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Pubmed 5.457E-22 2.022E-19 1.639E-18 1.011E-18 6 8
6 19934327 Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Pubmed 4.092E-21 1.264E-18 1.024E-17 7.583E-18 6 10
7 12024206 Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Pubmed 5.851E-20 1.549E-17 1.255E-16 1.084E-16 6 14
8 12622829 Expression of mCLOCK and other circadian clock-relevant proteins in the mouse suprachiasmatic nuclei. Pubmed 1.861E-19 4.311E-17 3.492E-16 3.448E-16 5 5
9 19839995 Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Pubmed 1.057E-18 1.089E-16 8.822E-16 1.958E-15 6 21
10 14750904 Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
11 9989497 A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
12 28886335 Macromolecular Assemblies of the Mammalian Circadian Clock. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
13 19605937 Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
14 12738229 Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
15 19917250 Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
16 9988221 Molecular bases for circadian clocks. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
17 25127877 Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
18 20978934 The role of polymorphisms in circadian pathway genes in breast tumorigenesis. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
19 10807566 Interacting molecular loops in the mammalian circadian clock. Pubmed 1.117E-18 1.089E-16 8.822E-16 2.069E-15 5 6
20 22936566 Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
21 20352049 Differential expression of the circadian clock in maternal and embryonic tissues of mice. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
22 21285316 Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
23 19222558 Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
24 20450826 Clock gene expression in gravid uterus and extra-embryonic tissues during late gestation in the mouse. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
25 15147242 Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
26 16717091 The polycomb group protein EZH2 is required for mammalian circadian clock function. Pubmed 3.907E-18 2.785E-16 2.256E-15 7.240E-15 5 7
27 28827343 Involvement of posttranscriptional regulation of Clock in the emergence of circadian clock oscillation during mouse development. Pubmed 1.042E-17 6.895E-16 5.586E-15 1.931E-14 5 8
28 24737000 Machine learning helps identify CHRONO as a circadian clock component. Pubmed 1.042E-17 6.895E-16 5.586E-15 1.931E-14 5 8
29 16528748 Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Pubmed 4.688E-17 2.995E-15 2.427E-14 8.686E-14 5 10
30 23555304 Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. Pubmed 6.346E-17 3.920E-15 3.176E-14 1.176E-13 6 39
31 21680841 A molecular mechanism for circadian clock negative feedback. Pubmed 1.473E-16 8.805E-15 7.134E-14 2.729E-13 5 12
32 18228528 Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Pubmed 2.393E-16 1.386E-14 1.123E-13 4.435E-13 5 13
33 19020302 Expression and functional analyses of circadian genes in mouse oocytes and preimplantation embryos: Cry1 is involved in the meiotic process independently of circadian clock regulation. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
34 26456331 Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
35 10487202 Regulation of clock genes. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
36 21156215 Expression of clock proteins in developing tooth. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
37 23584858 Clock gene expression in the human pituitary gland. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
38 16777965 The BMAL1 C terminus regulates the circadian transcription feedback loop. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
39 27168152 Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
40 24378737 Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
41 21613214 Biochemical analysis of the canonical model for the mammalian circadian clock. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
42 22217103 Comparison of β-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
43 26247999 Evidence for clock genes circadian rhythms in human full-term placenta. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
44 22558277 Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
45 25228643 Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Pubmed 1.421E-15 5.853E-14 4.742E-13 2.634E-12 4 4
46 26332085 Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon. Pubmed 3.032E-15 1.221E-13 9.896E-13 5.618E-12 6 72
47 16474407 Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Pubmed 7.106E-15 2.232E-13 1.808E-12 1.317E-11 4 5
48 12843397 Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Pubmed 7.106E-15 2.232E-13 1.808E-12 1.317E-11 4 5
49 25961797 Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus. Pubmed 7.106E-15 2.232E-13 1.808E-12 1.317E-11 4 5
50 22208286 Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. Pubmed 7.106E-15 2.232E-13 1.808E-12 1.317E-11 4 5
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 467 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PER3 PER3 interactions 2.430E-17 1.135E-14 7.631E-14 1.135E-14 6 17
2 int:PER1 PER1 interactions 5.115E-17 1.194E-14 8.032E-14 2.389E-14 7 53
3 int:CLOCK CLOCK interactions 3.971E-16 4.637E-14 3.118E-13 1.855E-13 7 70
4 int:ARNTL ARNTL interactions 3.971E-16 4.637E-14 3.118E-13 1.855E-13 7 70
5 int:PER2 PER2 interactions 9.310E-16 8.696E-14 5.848E-13 4.348E-13 6 29
6 int:CSNK1E CSNK1E interactions 3.139E-13 2.443E-11 1.643E-10 1.466E-10 7 177
7 int:DEC1 DEC1 interactions 1.743E-12 1.163E-10 7.821E-10 8.141E-10 5 32
8 int:CRY1 CRY1 interactions 2.336E-11 1.364E-9 9.169E-9 1.091E-8 6 146
9 int:CRY2 CRY2 interactions 3.494E-11 1.813E-9 1.219E-8 1.632E-8 6 156
10 int:ARNTL2 ARNTL2 interactions 3.878E-10 1.811E-8 1.218E-7 1.811E-7 4 25
11 int:CSNK1D CSNK1D interactions 6.114E-10 2.441E-8 1.641E-7 2.855E-7 5 99
12 int:NPAS2 NPAS2 interactions 6.272E-10 2.441E-8 1.641E-7 2.929E-7 4 28
13 int:RORC RORC interactions 2.513E-9 9.029E-8 6.071E-7 1.174E-6 4 39
14 int:CSNK2B CSNK2B interactions 1.638E-7 5.405E-6 3.634E-5 7.650E-5 5 301
15 int:USP2 USP2 interactions 1.736E-7 5.405E-6 3.634E-5 8.107E-5 4 110
16 int:BHLHE41 BHLHE41 interactions 6.999E-7 2.043E-5 1.374E-4 3.268E-4 3 37
17 int:TIMELESS TIMELESS interactions 5.784E-6 1.589E-4 1.069E-3 2.701E-3 3 74
18 int:CIPC CIPC interactions 1.512E-5 3.924E-4 2.639E-3 7.063E-3 2 12
19 int:KMT2A KMT2A interactions 2.180E-5 5.359E-4 3.604E-3 1.018E-2 3 115
20 int:BTRC BTRC interactions 3.045E-5 7.110E-4 4.781E-3 1.422E-2 4 403
21 int:DBP DBP interactions 3.500E-5 7.784E-4 5.235E-3 1.635E-2 2 18
22 int:TEKT4 TEKT4 interactions 9.262E-5 1.966E-3 1.322E-2 4.325E-2 2 29
23 int:NR1D2 NR1D2 interactions 1.060E-4 2.153E-3 1.448E-2 4.951E-2 2 31
24 int:TEX264 TEX264 interactions 2.454E-4 4.776E-3 3.212E-2
1.146E-1
 2 47
25 int:SIRT1 SIRT1 interactions 2.635E-4 4.807E-3 3.232E-2
1.231E-1
 3 266
26 int:VPS51 VPS51 interactions 2.779E-4 4.807E-3 3.232E-2
1.298E-1
 2 50
27 int:QPRT QPRT interactions 2.779E-4 4.807E-3 3.232E-2
1.298E-1
 2 50
28 int:TUFT1 TUFT1 interactions 3.007E-4 5.015E-3 3.372E-2
1.404E-1
 2 52
29 int:GRIPAP1 GRIPAP1 interactions 3.488E-4 5.444E-3 3.661E-2
1.629E-1
 2 56
30 int:SFPQ SFPQ interactions 3.536E-4 5.444E-3 3.661E-2
1.651E-1
 3 294
31 int:PHLDB3 PHLDB3 interactions 3.614E-4 5.444E-3 3.661E-2
1.688E-1
 2 57
32 int:VPS50 VPS50 interactions 3.872E-4 5.480E-3 3.685E-2
1.808E-1
 2 59
33 int:VPS53 VPS53 interactions 3.872E-4 5.480E-3 3.685E-2
1.808E-1
 2 59
34 int:NCKAP5L NCKAP5L interactions 4.005E-4 5.501E-3 3.699E-2
1.870E-1
 2 60
35 int:PHF21A PHF21A interactions 4.140E-4 5.523E-3 3.714E-2
1.933E-1
 2 61
36 int:PPP2R5E PPP2R5E interactions 4.276E-4 5.547E-3 3.730E-2
1.997E-1
 2 62
37 int:THAP11 THAP11 interactions 4.700E-4 5.932E-3 3.989E-2
2.195E-1
 2 65
38 int:EZH2 EZH2 interactions 5.138E-4 6.315E-3 4.246E-2
2.400E-1
 3 334
39 int:RABGAP1L RABGAP1L interactions 5.296E-4 6.341E-3 4.264E-2
2.473E-1
 2 69
40 int:NUF2 NUF2 interactions 5.606E-4 6.545E-3 4.402E-2
2.618E-1
 2 71
41 int:CCDC93 CCDC93 interactions 5.765E-4 6.567E-3 4.416E-2
2.692E-1
 2 72
42 int:RPRD1A RPRD1A interactions 6.591E-4 7.198E-3 4.841E-2
3.078E-1
 2 77
43 int:PPP2R5D PPP2R5D interactions 6.763E-4 7.198E-3 4.841E-2
3.158E-1
 2 78
44 int:KDM1A KDM1A interactions 6.819E-4 7.198E-3 4.841E-2
3.184E-1
 3 368
45 int:TFPT TFPT interactions 6.936E-4 7.198E-3 4.841E-2
3.239E-1
 2 79
46 int:PKN3 PKN3 interactions 7.112E-4 7.221E-3 4.856E-2
3.321E-1
 2 80
47 int:GOLGA5 GOLGA5 interactions 7.291E-4 7.244E-3 4.871E-2
3.405E-1
 2 81
48 int:OIP5 OIP5 interactions 7.471E-4 7.268E-3 4.888E-2
3.489E-1
 2 82
49 int:HAUS6 HAUS6 interactions 7.653E-4 7.294E-3 4.905E-2
3.574E-1
 2 83
50 int:DZIP3 DZIP3 interactions 9.190E-4 8.584E-3
5.772E-2
4.292E-1
 2 91
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12p12.2-p11.2 12p12.2-p11.2 5.193E-4 4.671E-3 1.321E-2 4.673E-3 1 2
2 1q25-q31 1q25-q31 1.038E-3 4.671E-3 1.321E-2 9.344E-3 1 4
3 12q23-q24.1 12q23-q24.1 1.557E-3 4.671E-3 1.321E-2 1.401E-2 1 6
4 1p36.23 1p36.23 3.889E-3 8.749E-3 2.475E-2 3.500E-2 1 15
5 11p15 11p15 1.214E-2 1.891E-2
5.349E-2
1.093E-1
 1 47
6 5q32 5q32 1.419E-2 1.891E-2
5.349E-2
1.277E-1
 1 55
7 4q12 4q12 1.471E-2 1.891E-2
5.349E-2
1.323E-1
 1 57
8 2q37.3 2q37.3 2.237E-2 2.516E-2
7.119E-2
2.013E-1
 1 87
9 17p13.1 17p13.1 3.124E-2 3.124E-2
8.838E-2
2.812E-1
 1 122
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 127 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 420 Basic helix-loop-helix proteins genenames.org 8.564E-7 2.569E-6 4.710E-6 2.569E-6 3 110
2 486 Basic helix-loop-helix proteins|Lysine acetyltransferases genenames.org 3.733E-3 4.609E-3 8.450E-3 1.120E-2 1 17
3 720 Regulators of G-protein signaling genenames.org 4.609E-3 4.609E-3 8.450E-3 1.383E-2 1 21

13: Coexpression [Display Chart] 9 input genes in category / 1134 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2637 Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.831E-11 1.001E-7 7.622E-7 1.001E-7 5 88
2 M9547 Genes up-regulated dendritic cells: Ly6G+ versus Ly6G-. MSigDB C7: Immunologic Signatures (v6.0) 6.469E-7 3.668E-4 2.792E-3 7.335E-4 4 199
3 M18441 Genes down-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.389E-6 5.249E-4 3.995E-3 1.575E-3 4 241
4 M16458 Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.934E-6 8.319E-4 6.332E-3 3.328E-3 3 77
5 M1243 Genes up-regulated by telomere shortening due to the knockout of TERC [GeneID=7012] in the presence of chronic liver damage. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.762E-6 8.531E-4 6.493E-3 4.266E-3 2 8
6 M12498 Molecular timetable composed of 162 time-indicating genes (182 probes) in the peripheral (liver) clock. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.114E-5 5.833E-3 4.440E-2 3.531E-2 3 169
7 M2445 Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.068E-5 5.833E-3 4.440E-2
5.747E-2
 3 199
8 M6648 Genes down-regulated in bone marrow-derived macrophages at 45 min of stimulation by LPS: wildtype versus IL10 [GeneID=3486]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 5.833E-3 4.440E-2
5.833E-2
 3 200
9 M9851 Genes down-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4intermediate versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 5.833E-3 4.440E-2
5.833E-2
 3 200
10 M8551 Genes up-regulated in CD8 T cells: KLRB1 high [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 5.833E-3 4.440E-2
5.833E-2
 3 200
11 M1284 Cluster PAM6: genes changed exclusively in normal liver tissue adjacent to hepatocellular carcinoma (HCC) from mice deficient for TXNIP [GeneID=10628]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.380E-4 1.362E-2
1.036E-1
1.565E-1
 2 46
12 16254190-Table1 Mouse Skin Zhang05 51genes GeneSigDB 1.441E-4 1.362E-2
1.036E-1
1.634E-1
 2 47
13 M3576 Genes down-regulated in the nucleus accumbens (a major reward center in the brain) 8 weeks after induction of CREB1 [GeneID=1385] expression in a transgenic Tet-Off system. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.123E-4 1.852E-2
1.410E-1
2.407E-1
 2 57
14 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.879E-4 2.332E-2
1.775E-1
3.265E-1
 3 358
15 18722011-SuppTable2j Human Leukemia Sanchez-Guijo08 77genes GeneSigDB 3.581E-4 2.607E-2
1.984E-1
4.060E-1
 2 74
16 M17500 Best cis-regulated quantitative trait loci (QTLs) in the mouse genome which modulate transcription in brain tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.678E-4 2.607E-2
1.984E-1
4.171E-1
 2 75
17 12509443-Table2 Human ProteinKinases Frevel03 425genes GeneSigDB 3.929E-4 2.621E-2
1.995E-1
4.455E-1
 3 398
18 M1278 Genes down-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.395E-4 2.769E-2
2.108E-1
4.984E-1
 2 82
19 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.761E-4 2.842E-2
2.163E-1
5.399E-1
 3 425
20 15297395-SuppTable3 Human Lymphoma Sriuranpong04 170genes GeneSigDB 8.618E-4 3.070E-2
2.337E-1
9.773E-1
 2 115
21 15985538-TableS1 Mouse Leukemia Gery05 153genes GeneSigDB 9.690E-4 3.070E-2
2.337E-1
1.000E0
 2 122
22 M12338 Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG, and CEBPD [GeneID=1050;1051;1054;1052]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.033E-3 3.070E-2
2.337E-1
1.000E0
 2 126
23 M6346 Genes up-regulated in Vd2 gamma delta T cells: LPS versus phorbol myristate acetate and ionomycin [PubChem=4792;3733]. MSigDB C7: Immunologic Signatures (v6.0) 1.133E-3 3.070E-2
2.337E-1
1.000E0
 2 132
24 21205295-TableS5 Mouse Viral Buonomo11 202genes GeneSigDB 1.167E-3 3.070E-2
2.337E-1
1.000E0
 2 134
25 M2397 Genes up-regulated in liver tissue upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.184E-3 3.070E-2
2.337E-1
1.000E0
 2 135
26 M18757 Genes up-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [GeneID=999]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.273E-3 3.070E-2
2.337E-1
1.000E0
 2 140
27 M2693 Genes down-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of TP53 [Gene ID=7157] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.364E-3 3.070E-2
2.337E-1
1.000E0
 2 145
28 M2983 Genes down-regulated in B lymphocytes stimulated by anti-IgM for 12h: wildtype versus ZFX [GeneID=7543] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.383E-3 3.070E-2
2.337E-1
1.000E0
 2 146
29 M6338 Genes down-regulated in Vd2 gamma delta T cells: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.402E-3 3.070E-2
2.337E-1
1.000E0
 2 147
30 M6695 Genes up-regulated in endothelial cells: untreated versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.498E-3 3.070E-2
2.337E-1
1.000E0
 2 152
31 16273092-TableS1a Human InVitro Bild06 206genes GeneSigDB 1.719E-3 3.070E-2
2.337E-1
1.000E0
 2 163
32 M6702 Genes up-regulated in endothelial cells: interferon beta versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.740E-3 3.070E-2
2.337E-1
1.000E0
 2 164
33 M1113 Up-regulated genes from the set C (Fig. 5a): specific to cells expressing AF4-MLL [GeneID=4299;4297] fusion protein alone. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.868E-3 3.070E-2
2.337E-1
1.000E0
 2 170
34 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.978E-3 3.070E-2
2.337E-1
1.000E0
 2 175
35 M6691 Genes down-regulated in fibroblasts: interferon alpha versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.160E-3 3.070E-2
2.337E-1
1.000E0
 2 183
36 M8175 Genes down-regulated in HEK293 cells expressing mutant NOD2 [GeneID=64127]: untreated versus muramyl dipeptide [PubChem=11620162] for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.206E-3 3.070E-2
2.337E-1
1.000E0
 2 185
37 M9724 Genes down-regulated in CD4 [GeneID=920] SMARTA cells: naïve versus during acute infection of LCMV. MSigDB C7: Immunologic Signatures (v6.0) 2.206E-3 3.070E-2
2.337E-1
1.000E0
 2 185
38 M2819 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL15 [Gene ID=3600]. MSigDB C6: Oncogenic Signatures (v6.0) 2.325E-3 3.070E-2
2.337E-1
1.000E0
 2 190
39 M1356 Early prostate development genes (up-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.332E-3 3.070E-2
2.337E-1
1.000E0
 1 6
40 M1179 Amplification hot spot 6: colocolized fragile sites and cancer genes in the 17p13-p11.1 region. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.332E-3 3.070E-2
2.337E-1
1.000E0
 1 6
41 15679045-Table1 Human Breast Tangir04 13genes Dexamethasone GeneSigDB 2.332E-3 3.070E-2
2.337E-1
1.000E0
 1 6
42 M9978 Genes up-regulated in ITGAM+ [GeneID=3684] dendritic cells: control versus primary acute viral infection. MSigDB C7: Immunologic Signatures (v6.0) 2.349E-3 3.070E-2
2.337E-1
1.000E0
 2 191
43 M2848 Genes down-regulated in MOLM-14 cells (AML) with knockdown of HOXA9 [Gene ID=3205] gene by RNAi vs controls. MSigDB C6: Oncogenic Signatures (v6.0) 2.398E-3 3.070E-2
2.337E-1
1.000E0
 2 193
44 M12824 Cluster 4 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts good survival outcome. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.472E-3 3.070E-2
2.337E-1
1.000E0
 2 196
45 M3247 Genes up-regulated in comparison of IgM-memory B cells versus Ig isotype switched memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 3.070E-2
2.337E-1
1.000E0
 2 196
46 M3298 Genes up-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 21 days after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 3.070E-2
2.337E-1
1.000E0
 2 196
47 M9892 Genes up-regulated in plasmacytoid dendritic cells: wildtype versus GFI1 [GeneID=2672] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 3.070E-2
2.337E-1
1.000E0
 2 197
48 M8226 Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype untreated versus RORC [GeneID=6097] knockout treated by digoxin [PubChem=2724385]. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.070E-2
2.337E-1
1.000E0
 2 198
49 M9817 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.070E-2
2.337E-1
1.000E0
 2 198
50 M7776 Genes up-regulated in macrophages after M. bovis BCG infection: 24h versus 48h. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.070E-2
2.337E-1
1.000E0
 2 198
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 438 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 7 input genes in category / 60 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 9 input genes in category / 565 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4325:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.481E-9 1.402E-6 9.695E-6 1.402E-6 4 154
2 hsa-miR-7703:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.247E-7 6.347E-5 4.389E-4 1.269E-4 4 474
3 hsa-miR-181d-5p:Functional MTI Functional MTI miRTarbase 5.174E-6 7.539E-4 5.213E-3 2.924E-3 3 288
4 hsa-miR-181c-5p:Functional MTI Functional MTI miRTarbase 5.337E-6 7.539E-4 5.213E-3 3.016E-3 3 291
5 hsa-miR-181b-5p:Functional MTI Functional MTI miRTarbase 1.139E-5 1.287E-3 8.899E-3 6.435E-3 3 375
6 hsa-miR-3064-5p:TargetScan hsa-miR-3064-5p TargetScan 1.541E-5 1.451E-3 1.003E-2 8.706E-3 3 415
7 hsa-miR-22-3p:TargetScan hsa-miR-22-3p TargetScan 1.910E-5 1.542E-3 1.066E-2 1.079E-2 3 446
8 hsa-miR-138-5p:TargetScan hsa-miR-138-5p TargetScan 2.466E-5 1.579E-3 1.092E-2 1.394E-2 3 486
9 hsa-miR-4529-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.515E-5 1.579E-3 1.092E-2 1.421E-2 2 61
10 hsa-miR-875-5p:TargetScan hsa-miR-875-5p TargetScan 3.609E-5 1.957E-3 1.353E-2 2.039E-2 2 73
11 hsa-miR-1290:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.811E-5 1.957E-3 1.353E-2 2.153E-2 2 75
12 hsa-miR-302d-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.214E-5 3.767E-3 2.605E-2 4.641E-2 2 110
13 hsa-miR-302b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.668E-5 3.767E-3 2.605E-2 4.897E-2 2 113
14 hsa-miR-552-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.147E-4 4.210E-3 2.911E-2
6.482E-2
 2 130
15 AACATTC,MIR-409-3P:MSigDB AACATTC,MIR-409-3P:MSigDB MSigDB 1.219E-4 4.210E-3 2.911E-2
6.887E-2
 2 134
16 hsa-miR-494-3p:Functional MTI Functional MTI miRTarbase 1.293E-4 4.210E-3 2.911E-2
7.304E-2
 2 138
17 hsa-miR-510-5p:Functional MTI Functional MTI miRTarbase 1.507E-4 4.210E-3 2.911E-2
8.514E-2
 2 149
18 hsa-miR-136-5p:Functional MTI Functional MTI miRTarbase 1.737E-4 4.210E-3 2.911E-2
9.815E-2
 2 160
19 hsa-miR-548f-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.847E-4 4.210E-3 2.911E-2
1.044E-1
 2 165
20 hsa-miR-490-3p:TargetScan hsa-miR-490-3p TargetScan 1.847E-4 4.210E-3 2.911E-2
1.044E-1
 2 165
21 hsa-miR-548ar-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.870E-4 4.210E-3 2.911E-2
1.056E-1
 2 166
22 hsa-miR-548e-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.870E-4 4.210E-3 2.911E-2
1.056E-1
 2 166
23 hsa-miR-548az-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.870E-4 4.210E-3 2.911E-2
1.056E-1
 2 166
24 hsa-miR-28-5p:TargetScan hsa-miR-28-5p TargetScan 1.938E-4 4.210E-3 2.911E-2
1.095E-1
 2 169
25 hsa-miR-708-5p:TargetScan hsa-miR-708-5p TargetScan 1.938E-4 4.210E-3 2.911E-2
1.095E-1
 2 169
26 hsa-miR-548a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.938E-4 4.210E-3 2.911E-2
1.095E-1
 2 169
27 hsa-miR-557:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.396E-4 4.609E-3 3.187E-2
1.354E-1
 2 188
28 hsa-miR-507:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.396E-4 4.609E-3 3.187E-2
1.354E-1
 2 188
29 hsa-miR-6515-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.422E-4 4.609E-3 3.187E-2
1.368E-1
 2 189
30 hsa-miR-4465:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.447E-4 4.609E-3 3.187E-2
1.383E-1
 2 190
31 hsa-miR-1297:Functional MTI Functional MTI miRTarbase 2.551E-4 4.649E-3 3.215E-2
1.441E-1
 2 194
32 ATATGCA,MIR-448:MSigDB ATATGCA,MIR-448:MSigDB MSigDB 2.792E-4 4.930E-3 3.409E-2
1.578E-1
 2 203
33 CTGAGCC,MIR-24:MSigDB CTGAGCC,MIR-24:MSigDB MSigDB 3.160E-4 5.410E-3 3.741E-2
1.785E-1
 2 216
34 hsa-miR-876-5p:TargetScan hsa-miR-876-5p TargetScan 3.549E-4 5.898E-3 4.078E-2
2.005E-1
 2 229
35 hsa-miR-3187-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.674E-4 5.930E-3 4.101E-2
2.076E-1
 2 233
36 hsa-miR-5582-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.159E-4 6.527E-3 4.514E-2
2.350E-1
 2 248
37 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 4.709E-4 6.605E-3 4.567E-2
2.661E-1
 2 264
38 hsa-miR-150-5p:TargetScan hsa-miR-150-5p TargetScan 4.780E-4 6.605E-3 4.567E-2
2.701E-1
 2 266
39 hsa-miR-505-3p.2:TargetScan hsa-miR-505-3p.2 TargetScan 4.816E-4 6.605E-3 4.567E-2
2.721E-1
 2 267
40 hsa-miR-548t-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.888E-4 6.605E-3 4.567E-2
2.762E-1
 2 269
41 hsa-miR-548az-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.888E-4 6.605E-3 4.567E-2
2.762E-1
 2 269
42 hsa-miR-142-3p.1:TargetScan hsa-miR-142-3p.1 TargetScan 5.033E-4 6.605E-3 4.567E-2
2.844E-1
 2 273
43 hsa-miR-3175:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.070E-4 6.605E-3 4.567E-2
2.865E-1
 2 274
44 hsa-miR-1207-3p:PITA hsa-miR-1207-3p:PITA TOP PITA 5.144E-4 6.605E-3 4.567E-2
2.906E-1
 2 276
45 hsa-miR-5692a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.636E-4 6.726E-3 4.651E-2
3.184E-1
 2 289
46 hsa-miR-605:PITA hsa-miR-605:PITA TOP PITA 5.675E-4 6.726E-3 4.651E-2
3.206E-1
 2 290
47 CAGTGTT,MIR-141:MSigDB CAGTGTT,MIR-141:MSigDB MSigDB 5.714E-4 6.726E-3 4.651E-2
3.228E-1
 2 291
48 CAGTGTT,MIR-200A:MSigDB CAGTGTT,MIR-200A:MSigDB MSigDB 5.714E-4 6.726E-3 4.651E-2
3.228E-1
 2 291
49 hsa-miR-107:Functional MTI Functional MTI miRTarbase 6.070E-4 6.999E-3 4.840E-2
3.429E-1
 2 300
50 hsa-miR-367-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.376E-4 8.335E-3
5.764E-2
4.168E-1
 2 331
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 2977 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000129236 CKI-7 Stitch 6.934E-12 2.064E-8 1.770E-7 2.064E-8 5 53
2 CID000000896 melatonin Stitch 3.429E-11 5.104E-8 4.378E-7 1.021E-7 7 443
3 ctd:D008550 Melatonin CTD 1.201E-10 1.191E-7 1.022E-6 3.574E-7 6 246
4 CID000159268 zinc borate Stitch 3.977E-10 2.960E-7 2.538E-6 1.184E-6 4 32
5 CID000002196 aniracetam Stitch 6.839E-10 3.621E-7 3.105E-6 2.036E-6 5 130
6 CID005327130 CT 6 Stitch 7.297E-10 3.621E-7 3.105E-6 2.172E-6 4 37
7 CID000445446 mM Q Stitch 1.118E-9 4.755E-7 4.078E-6 3.329E-6 4 41
8 CID000071158 acamprosate Stitch 1.263E-8 4.700E-6 4.031E-5 3.760E-5 4 74
9 CID006323354 heme As Stitch 1.917E-8 6.342E-6 5.439E-5 5.708E-5 4 82
10 ctd:D005473 Fluoxetine CTD 7.450E-8 2.218E-5 1.902E-4 2.218E-4 5 331
11 ctd:C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine CTD 1.231E-7 3.333E-5 2.858E-4 3.666E-4 3 27
12 CID000002891 CAS 68-19-9 Stitch 1.915E-7 4.751E-5 4.075E-4 5.702E-4 4 145
13 ctd:D011239 Prednisolone CTD 2.988E-7 6.843E-5 5.869E-4 8.896E-4 4 162
14 ctd:D008752 Methylene Chloride CTD 3.625E-7 7.422E-5 6.366E-4 1.079E-3 4 170
15 ctd:C025340 manganese chloride CTD 3.740E-7 7.422E-5 6.366E-4 1.113E-3 5 458
16 CID000000281 carbon monoxide Stitch 1.277E-6 2.377E-4 2.038E-3 3.803E-3 4 233
17 CID000134018 febuxostat Stitch 2.816E-6 4.931E-4 4.229E-3 8.383E-3 3 75
18 ctd:C002979 selenomethylselenocysteine CTD 3.049E-6 5.043E-4 4.325E-3 9.078E-3 3 77
19 CID000198746 Mi-1 Stitch 3.860E-6 5.745E-4 4.927E-3 1.149E-2 2 8
20 CID000002451 brotizolam Stitch 3.860E-6 5.745E-4 4.927E-3 1.149E-2 2 8
21 CID000159408 TiNi Stitch 6.710E-6 9.513E-4 8.158E-3 1.998E-2 3 100
22 CID000073000 pterin Stitch 8.459E-6 1.145E-3 9.816E-3 2.518E-2 3 108
23 CID009809426 D0303 Stitch 1.074E-5 1.335E-3 1.145E-2 3.198E-2 2 13
24 CID000001229 2,5-dimethoxy-4-iodoamphetamine Stitch 1.076E-5 1.335E-3 1.145E-2 3.203E-2 3 117
25 CID002255489 CT 0 Stitch 1.445E-5 1.721E-3 1.476E-2 4.303E-2 2 15
26 CID000004973 heme b Stitch 1.643E-5 1.881E-3 1.613E-2 4.891E-2 4 444
27 CID000435143 NSC-364372 Stitch 2.306E-5 2.542E-3 2.180E-2
6.865E-2
 4 484
28 7103 UP thapsigargin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.067E-5 3.260E-3 2.796E-2
9.129E-2
 3 166
29 ctd:D006854 Hydrocortisone CTD 3.178E-5 3.263E-3 2.798E-2
9.461E-2
 3 168
30 1746 UP Mometasone furoate [83919-23-7]; Up 200; 7.6uM; HL60; HG-U133A Broad Institute CMAP Up 3.590E-5 3.562E-3 3.055E-2
1.069E-1
 3 175
31 5745 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.714E-5 3.566E-3 3.058E-2
1.106E-1
 3 177
32 CID000002728 chlorpropham Stitch 4.463E-5 3.768E-3 3.231E-2
1.329E-1
 2 26
33 5567 DN Rapamycin; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.659E-5 3.768E-3 3.231E-2
1.387E-1
 3 191
34 CID016058609 cm y Stitch 4.820E-5 3.768E-3 3.231E-2
1.435E-1
 2 27
35 6959 DN wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.956E-5 3.768E-3 3.231E-2
1.475E-1
 3 195
36 2516 DN Trioxsalen [3902-71-4]; Down 200; 17.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.032E-5 3.768E-3 3.231E-2
1.498E-1
 3 196
37 1677 DN Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.186E-5 3.768E-3 3.231E-2
1.544E-1
 3 198
38 1551 UP Oxybutynin chloride [1508-65-2]; Up 200; 10.2uM; HL60; HG-U133A Broad Institute CMAP Up 5.186E-5 3.768E-3 3.231E-2
1.544E-1
 3 198
39 2194 DN Beta-Escin [11072-93-8]; Down 200; 3.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.186E-5 3.768E-3 3.231E-2
1.544E-1
 3 198
40 2575 DN Guanadrel sulfate [22195-34-2]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.186E-5 3.768E-3 3.231E-2
1.544E-1
 3 198
41 CID011527397 2H1H Stitch 5.189E-5 3.768E-3 3.231E-2
1.545E-1
 2 28
42 CID000082267 sulfamide Stitch 6.380E-5 4.522E-3 3.878E-2
1.899E-1
 2 31
43 CID000002622 AC1L1E3B Stitch 1.294E-4 8.962E-3
7.686E-2
3.854E-1
 2 44
44 CID000012967 N-ethyl-N-nitrosourea Stitch 1.374E-4 9.299E-3
7.974E-2
4.091E-1
 3 275
45 CID000002631 CAS 64485-93-4 Stitch 1.674E-4 1.083E-2
9.292E-2
4.984E-1
 2 50
46 CID000002274 azthreonam Stitch 1.674E-4 1.083E-2
9.292E-2
4.984E-1
 2 50
47 CID000443249 C11536 Stitch 1.742E-4 1.103E-2
9.463E-2
5.186E-1
 2 51
48 CID000010908 tert-butyl acetate Stitch 2.255E-4 1.399E-2
1.200E-1
6.714E-1
 2 58
49 ctd:C111855 6-formylindolo(3,2-b)carbazole CTD 2.414E-4 1.467E-2
1.258E-1
7.187E-1
 2 60
50 CID000008404 tetralin Stitch 2.662E-4 1.585E-2
1.359E-1
7.925E-1
 2 63
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 187 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0026705 Mucopolysaccharidosis II DisGeNET Curated 1.445E-11 2.702E-9 1.570E-8 2.702E-9 4 11
2 C0751758 Advanced Sleep Phase Syndrome DisGeNET BeFree 4.737E-10 2.953E-8 1.716E-7 8.858E-8 3 4
3 C0854739 Advanced sleep phase DisGeNET BeFree 4.737E-10 2.953E-8 1.716E-7 8.858E-8 3 4
4 C0085159 Seasonal Affective Disorder DisGeNET Curated 1.567E-9 7.324E-8 4.256E-7 2.930E-7 4 32
5 C0393770 Delayed Sleep Phase Syndrome DisGeNET BeFree 2.367E-9 8.853E-8 5.145E-7 4.427E-7 3 6
6 C0851578 Sleep Disorders DisGeNET BeFree 3.211E-9 1.001E-7 5.815E-7 6.005E-7 4 38
7 C0086132 Depressive Symptoms DisGeNET Curated 4.570E-9 1.221E-7 7.094E-7 8.545E-7 5 135
8 C0236848 Age-related cognitive decline DisGeNET BeFree 2.600E-8 6.076E-7 3.531E-6 4.861E-6 3 12
9 C0013274 Patent ductus arteriosus DisGeNET Curated 6.351E-8 1.320E-6 7.668E-6 1.188E-5 5 228
10 C0037317 Sleep disturbances DisGeNET Curated 7.526E-8 1.407E-6 8.178E-6 1.407E-5 4 82
11 C0854740 Delayed sleep phase DisGeNET BeFree 2.742E-7 4.661E-6 2.709E-5 5.127E-5 2 2
12 C0231311 Jet Lag Syndrome DisGeNET BeFree 8.224E-7 1.098E-5 6.383E-5 1.538E-4 2 3
13 C3807327 ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1 DisGeNET Curated 8.224E-7 1.098E-5 6.383E-5 1.538E-4 2 3
14 C0813142 Circadian Rhythm Disorders DisGeNET BeFree 8.224E-7 1.098E-5 6.383E-5 1.538E-4 2 3
15 C0349530 Early gastric cancer DisGeNET BeFree 1.072E-6 1.336E-5 7.765E-5 2.004E-4 3 39
16 C0871610 winter depression DisGeNET BeFree 1.644E-6 1.922E-5 1.117E-4 3.075E-4 2 4
17 C1306067 Drug-induced paranoid state DisGeNET Curated 2.740E-6 3.014E-5 1.751E-4 5.123E-4 2 5
18 C0038587 Substance Withdrawal Syndrome DisGeNET Curated 3.414E-6 3.547E-5 2.061E-4 6.385E-4 3 57
19 C0600427 Cocaine Dependence DisGeNET Curated 5.575E-6 5.376E-5 3.124E-4 1.042E-3 3 67
20 C1319200 Postoperative confusion DisGeNET BeFree 5.750E-6 5.376E-5 3.124E-4 1.075E-3 2 7
21 C0020624 Hypomenorrhea DisGeNET BeFree 7.664E-6 6.825E-5 3.966E-4 1.433E-3 2 8
22 C0525045 Mood Disorders DisGeNET Curated 1.594E-5 1.355E-4 7.872E-4 2.980E-3 4 313
23 C1456246 Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 1.804E-5 1.467E-4 8.525E-4 3.374E-3 2 12
24 C0947785 [D]Sleep disturbances (& [hypersomnia] or [insomnia]) DisGeNET BeFree 2.487E-5 1.937E-4 1.126E-3 4.650E-3 2 14
25 C0009088 Cluster Headache DisGeNET BeFree 2.868E-5 2.145E-4 1.247E-3 5.364E-3 2 15
26 C0022346 Icterus DisGeNET Curated 4.282E-5 3.079E-4 1.789E-3 8.007E-3 3 132
27 C0041696 Unipolar Depression DisGeNET Curated 4.961E-5 3.436E-4 1.997E-3 9.278E-3 4 418
28 C0005587 Depression, Bipolar DisGeNET Curated 5.183E-5 3.461E-4 2.011E-3 9.692E-3 2 20
29 C0917801 Sleeplessness DisGeNET Curated 1.524E-4 9.828E-4 5.711E-3 2.850E-2 2 34
30 C0032269 Pneumococcal Infections DisGeNET Curated 2.115E-4 1.319E-3 7.663E-3 3.956E-2 2 40
31 C0338831 Manic DisGeNET Curated 4.157E-4 2.508E-3 1.457E-2
7.774E-2
 2 56
32 C0019337 Heroin Dependence DisGeNET Curated 4.460E-4 2.606E-3 1.514E-2
8.340E-2
 2 58
33 C0001956 alcohol use disorder DisGeNET Curated 5.262E-4 2.967E-3 1.724E-2
9.839E-2
 2 63
34 C0751226 Hypersomnia, Recurrent DisGeNET BeFree 5.554E-4 2.967E-3 1.724E-2
1.039E-1
 1 1
35 cv:C1858496 Advanced sleep phase syndrome, familial Clinical Variations 5.554E-4 2.967E-3 1.724E-2
1.039E-1
 1 1
36 C1456781 Benign melanocytic nevus DisGeNET BeFree 6.310E-4 3.278E-3 1.905E-2
1.180E-1
 2 69
37 C1263846 Attention deficit hyperactivity disorder DisGeNET Curated 7.182E-4 3.630E-3 2.109E-2
1.343E-1
 3 343
38 C0027960 Nevus DisGeNET Curated 8.056E-4 3.964E-3 2.304E-2
1.506E-1
 2 78
39 C0231341 Premature aging syndrome DisGeNET Curated 1.047E-3 4.615E-3 2.682E-2
1.958E-1
 2 89
40 OMIN:604348 ADVANCED SLEEP-PHASE SYNDROME, FAMILIAL OMIM 1.110E-3 4.615E-3 2.682E-2
2.077E-1
 1 2
41 C4041558 Cone-rod synaptic disorder, congenital nonprogressive DisGeNET Curated 1.110E-3 4.615E-3 2.682E-2
2.077E-1
 1 2
42 C0033138 Primary Hypersomnia DisGeNET BeFree 1.110E-3 4.615E-3 2.682E-2
2.077E-1
 1 2
43 C0393735 Headache Disorders DisGeNET BeFree 1.110E-3 4.615E-3 2.682E-2
2.077E-1
 1 2
44 C0519066 Acute Q fever DisGeNET BeFree 1.110E-3 4.615E-3 2.682E-2
2.077E-1
 1 2
45 C0751757 Hypersomnolence, Idiopathic DisGeNET BeFree 1.110E-3 4.615E-3 2.682E-2
2.077E-1
 1 2
46 C0001973 Alcoholic Intoxication, Chronic DisGeNET Curated 1.139E-3 4.629E-3 2.690E-2
2.129E-1
 3 402
47 C0520679 Sleep Apnea, Obstructive DisGeNET Curated 1.593E-3 6.106E-3 3.548E-2
2.980E-1
 2 110
48 C0278562 Esophageal neoplasm metastatic DisGeNET BeFree 1.665E-3 6.106E-3 3.548E-2
3.114E-1
 1 3
49 C1858496 Advanced Sleep-Phase Syndrome, Familial DisGeNET Curated 1.665E-3 6.106E-3 3.548E-2
3.114E-1
 1 3
50 C0271638 Type 2 diabetes mellitus in obese DisGeNET BeFree 1.665E-3 6.106E-3 3.548E-2
3.114E-1
 1 3
Show 45 more annotations