Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc5_19, positive side

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1: GO: Molecular Function [Display Chart] 19 input genes in category / 88 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding 1.789E-30 7.873E-29 3.984E-28 1.575E-28 13 50
2 GO:0004879 nuclear receptor activity 1.789E-30 7.873E-29 3.984E-28 1.575E-28 13 50
3 GO:0003707 steroid hormone receptor activity 1.496E-26 4.388E-25 2.220E-24 1.316E-24 12 59
4 GO:0003708 retinoic acid receptor activity 3.239E-18 7.125E-17 3.606E-16 2.850E-16 6 7
5 GO:0042974 retinoic acid receptor binding 1.292E-16 2.274E-15 1.151E-14 1.137E-14 8 51
6 GO:0046965 retinoid X receptor binding 3.421E-14 5.018E-13 2.539E-12 3.011E-12 6 22
7 GO:0035257 nuclear hormone receptor binding 1.797E-12 2.259E-11 1.143E-10 1.581E-10 8 161
8 GO:0051427 hormone receptor binding 5.056E-12 5.562E-11 2.814E-10 4.449E-10 8 183
9 GO:0004886 9-cis retinoic acid receptor activity 8.948E-10 8.749E-9 4.427E-8 7.874E-8 3 3
10 GO:0003713 transcription coactivator activity 1.386E-8 1.219E-7 6.170E-7 1.219E-6 7 310
11 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.033E-6 8.267E-6 4.183E-5 9.094E-5 6 357
12 GO:0038181 bile acid receptor activity 2.945E-6 1.993E-5 1.009E-4 2.591E-4 2 3
13 GO:0070644 vitamin D response element binding 2.945E-6 1.993E-5 1.009E-4 2.591E-4 2 3
14 GO:0044323 retinoic acid-responsive element binding 9.804E-6 6.162E-5 3.118E-4 8.627E-4 2 5
15 GO:0004887 thyroid hormone receptor activity 2.740E-5 1.607E-4 8.134E-4 2.411E-3 2 8
16 GO:0032052 bile acid binding 3.521E-5 1.936E-4 9.799E-4 3.098E-3 2 9
17 GO:0033293 monocarboxylic acid binding 6.739E-5 3.488E-4 1.765E-3 5.930E-3 3 79
18 GO:0042809 vitamin D receptor binding 1.324E-4 6.471E-4 3.274E-3 1.165E-2 2 17
19 GO:0005496 steroid binding 1.484E-4 6.873E-4 3.478E-3 1.306E-2 3 103
20 GO:0035326 enhancer binding 1.616E-4 7.109E-4 3.597E-3 1.422E-2 3 106
21 GO:0008144 drug binding 3.368E-4 1.411E-3 7.142E-3 2.964E-2 3 136
22 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 4.422E-4 1.769E-3 8.950E-3 3.891E-2 4 365
23 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 5.097E-4 1.950E-3 9.868E-3 4.485E-2 4 379
24 GO:0000987 proximal promoter sequence-specific DNA binding 6.128E-4 2.247E-3 1.137E-2
5.392E-2
 4 398
25 GO:1902122 chenodeoxycholic acid binding 1.018E-3 3.090E-3 1.563E-2
8.960E-2
 1 1
26 GO:1902121 lithocholic acid binding 1.018E-3 3.090E-3 1.563E-2
8.960E-2
 1 1
27 GO:0038186 lithocholic acid receptor activity 1.018E-3 3.090E-3 1.563E-2
8.960E-2
 1 1
28 GO:0008434 calcitriol receptor activity 1.018E-3 3.090E-3 1.563E-2
8.960E-2
 1 1
29 GO:1902098 calcitriol binding 1.018E-3 3.090E-3 1.563E-2
8.960E-2
 1 1
30 GO:0003714 transcription corepressor activity 1.646E-3 4.828E-3 2.443E-2
1.448E-1
 3 235
31 GO:0031406 carboxylic acid binding 1.748E-3 4.962E-3 2.511E-2
1.538E-1
 3 240
32 GO:0043177 organic acid binding 1.811E-3 4.975E-3 2.518E-2
1.594E-1
 3 243
33 GO:0004874 aryl hydrocarbon receptor activity 2.035E-3 4.975E-3 2.518E-2
1.791E-1
 1 2
34 GO:1902271 D3 vitamins binding 2.035E-3 4.975E-3 2.518E-2
1.791E-1
 1 2
35 GO:0032810 sterol response element binding 2.035E-3 4.975E-3 2.518E-2
1.791E-1
 1 2
36 GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity 2.035E-3 4.975E-3 2.518E-2
1.791E-1
 1 2
37 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 2.172E-3 5.167E-3 2.614E-2
1.912E-1
 3 259
38 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 2.341E-3 5.420E-3 2.743E-2
2.060E-1
 2 71
39 GO:0004882 androgen receptor activity 3.052E-3 6.886E-3 3.484E-2
2.685E-1
 1 3
40 GO:0031490 chromatin DNA binding 3.334E-3 7.335E-3 3.712E-2
2.934E-1
 2 85
41 GO:0001158 enhancer sequence-specific DNA binding 3.976E-3 8.521E-3 4.312E-2
3.499E-1
 2 93
42 GO:0034191 apolipoprotein A-I receptor binding 4.067E-3 8.521E-3 4.312E-2
3.579E-1
 1 4
43 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 4.945E-3 9.936E-3
5.028E-2
4.351E-1
 2 104
44 GO:0001134 transcription regulator recruiting activity 5.081E-3 9.936E-3
5.028E-2
4.471E-1
 1 5
45 GO:0030375 thyroid hormone receptor coactivator activity 5.081E-3 9.936E-3
5.028E-2
4.471E-1
 1 5
46 GO:0043178 alcohol binding 5.711E-3 1.093E-2
5.529E-2
5.026E-1
 2 112
47 GO:0034190 apolipoprotein receptor binding 7.107E-3 1.303E-2
6.593E-2
6.254E-1
 1 7
48 GO:0005000 vasopressin receptor activity 7.107E-3 1.303E-2
6.593E-2
6.254E-1
 1 7
49 GO:0005499 vitamin D binding 8.118E-3 1.458E-2
7.377E-2
7.144E-1
 1 8
50 GO:0035014 phosphatidylinositol 3-kinase regulator activity 9.128E-3 1.607E-2
8.130E-2
8.033E-1
 1 9
Show 45 more annotations

2: GO: Biological Process [Display Chart] 19 input genes in category / 912 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006367 transcription initiation from RNA polymerase II promoter 7.322E-23 6.678E-20 4.937E-19 6.678E-20 13 175
2 GO:0030522 intracellular receptor signaling pathway 6.037E-22 2.753E-19 2.035E-18 5.506E-19 14 299
3 GO:0006352 DNA-templated transcription, initiation 3.338E-21 1.015E-18 7.502E-18 3.044E-18 13 233
4 GO:0043401 steroid hormone mediated signaling pathway 3.974E-20 9.060E-18 6.698E-17 3.624E-17 12 189
5 GO:0071383 cellular response to steroid hormone stimulus 6.040E-20 1.102E-17 8.145E-17 5.509E-17 13 290
6 GO:0009755 hormone-mediated signaling pathway 4.179E-19 6.352E-17 4.696E-16 3.811E-16 12 229
7 GO:0048384 retinoic acid receptor signaling pathway 1.551E-16 2.021E-14 1.494E-13 1.415E-13 8 52
8 GO:0031641 regulation of myelination 1.070E-12 1.219E-10 9.014E-10 9.754E-10 6 37
9 GO:0042552 myelination 1.681E-9 1.539E-7 1.138E-6 1.533E-6 6 121
10 GO:0007272 ensheathment of neurons 1.857E-9 1.539E-7 1.138E-6 1.693E-6 6 123
11 GO:0008366 axon ensheathment 1.857E-9 1.539E-7 1.138E-6 1.693E-6 6 123
12 GO:0055012 ventricular cardiac muscle cell differentiation 3.710E-9 2.819E-7 2.085E-6 3.383E-6 4 20
13 GO:0035265 organ growth 1.171E-8 8.212E-7 6.072E-6 1.068E-5 6 167
14 GO:0002067 glandular epithelial cell differentiation 2.195E-7 1.430E-5 1.057E-4 2.002E-4 4 53
15 GO:0030850 prostate gland development 2.953E-7 1.796E-5 1.328E-4 2.693E-4 4 57
16 GO:0003417 growth plate cartilage development 5.000E-7 2.850E-5 2.107E-4 4.560E-4 3 16
17 GO:0043010 camera-type eye development 7.733E-7 4.148E-5 3.067E-4 7.052E-4 6 339
18 GO:0090182 regulation of secretion of lysosomal enzymes 9.862E-7 4.997E-5 3.694E-4 8.994E-4 2 2
19 GO:0003416 endochondral bone growth 1.574E-6 7.555E-5 5.586E-4 1.436E-3 3 23
20 GO:0001654 eye development 1.775E-6 8.092E-5 5.983E-4 1.618E-3 6 391
21 GO:0098868 bone growth 2.042E-6 8.866E-5 6.555E-4 1.862E-3 3 25
22 GO:0002068 glandular epithelial cell development 2.306E-6 9.561E-5 7.069E-4 2.103E-3 3 26
23 GO:0061037 negative regulation of cartilage development 2.593E-6 1.028E-4 7.602E-4 2.365E-3 3 27
24 GO:0038183 bile acid signaling pathway 2.957E-6 1.124E-4 8.307E-4 2.697E-3 2 3
25 GO:0060351 cartilage development involved in endochondral bone morphogenesis 3.235E-6 1.180E-4 8.725E-4 2.950E-3 3 29
26 GO:0055007 cardiac muscle cell differentiation 5.332E-6 1.853E-4 1.370E-3 4.863E-3 4 117
27 GO:0001893 maternal placenta development 5.772E-6 1.853E-4 1.370E-3 5.264E-3 3 35
28 GO:0048550 negative regulation of pinocytosis 5.910E-6 1.853E-4 1.370E-3 5.390E-3 2 4
29 GO:0048608 reproductive structure development 6.007E-6 1.853E-4 1.370E-3 5.478E-3 6 483
30 GO:0003206 cardiac chamber morphogenesis 6.094E-6 1.853E-4 1.370E-3 5.558E-3 4 121
31 GO:0061458 reproductive system development 6.298E-6 1.853E-4 1.370E-3 5.743E-3 6 487
32 GO:0032526 response to retinoic acid 6.934E-6 1.976E-4 1.461E-3 6.324E-3 4 125
33 GO:0060331 negative regulation of response to interferon-gamma 9.844E-6 2.640E-4 1.952E-3 8.977E-3 2 5
34 GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway 9.844E-6 2.640E-4 1.952E-3 8.977E-3 2 5
35 GO:0001960 negative regulation of cytokine-mediated signaling pathway 1.083E-5 2.821E-4 2.086E-3 9.875E-3 3 43
36 GO:0035051 cardiocyte differentiation 1.248E-5 3.161E-4 2.337E-3 1.138E-2 4 145
37 GO:0060761 negative regulation of response to cytokine stimulus 1.419E-5 3.431E-4 2.536E-3 1.294E-2 3 47
38 GO:0010887 negative regulation of cholesterol storage 1.476E-5 3.431E-4 2.536E-3 1.346E-2 2 6
39 GO:0003406 retinal pigment epithelium development 1.476E-5 3.431E-4 2.536E-3 1.346E-2 2 6
40 GO:0019216 regulation of lipid metabolic process 1.538E-5 3.431E-4 2.536E-3 1.402E-2 5 327
41 GO:0002065 columnar/cuboidal epithelial cell differentiation 1.542E-5 3.431E-4 2.536E-3 1.407E-2 4 153
42 GO:0046890 regulation of lipid biosynthetic process 1.665E-5 3.615E-4 2.673E-3 1.518E-2 4 156
43 GO:0001655 urogenital system development 2.284E-5 4.734E-4 3.500E-3 2.083E-2 5 355
44 GO:0060350 endochondral bone morphogenesis 2.284E-5 4.734E-4 3.500E-3 2.083E-2 3 55
45 GO:0003205 cardiac chamber development 2.444E-5 4.953E-4 3.662E-3 2.229E-2 4 172
46 GO:0060534 trachea cartilage development 2.751E-5 5.338E-4 3.947E-3 2.509E-2 2 8
47 GO:0048548 regulation of pinocytosis 2.751E-5 5.338E-4 3.947E-3 2.509E-2 2 8
48 GO:0001101 response to acid chemical 2.858E-5 5.388E-4 3.984E-3 2.607E-2 5 372
49 GO:0060562 epithelial tube morphogenesis 2.895E-5 5.388E-4 3.984E-3 2.640E-2 5 373
50 GO:0002066 columnar/cuboidal epithelial cell development 3.278E-5 5.979E-4 4.420E-3 2.989E-2 3 62
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 19 input genes in category / 25 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000790 nuclear chromatin 5.185E-7 1.296E-5 4.947E-5 1.296E-5 6 324
2 GO:0000785 chromatin 5.515E-6 6.893E-5 2.630E-4 1.379E-4 6 487
3 GO:0005667 transcription factor complex 2.429E-5 2.024E-4 7.723E-4 6.072E-4 5 368
4 GO:0090575 RNA polymerase II transcription factor complex 1.476E-4 9.226E-4 3.520E-3 3.690E-3 3 105
5 GO:0044798 nuclear transcription factor complex 3.031E-4 1.285E-3 4.904E-3 7.579E-3 3 134
6 GO:0043235 receptor complex 3.084E-4 1.285E-3 4.904E-3 7.710E-3 4 339
7 GO:0000791 euchromatin 7.179E-4 2.564E-3 9.783E-3 1.795E-2 2 40
8 GO:0034752 cytosolic aryl hydrocarbon receptor complex 9.968E-4 3.115E-3 1.189E-2 2.492E-2 1 1
9 GO:0034753 nuclear aryl hydrocarbon receptor complex 1.993E-3 5.535E-3 2.112E-2 4.982E-2 1 2
10 GO:0034751 aryl hydrocarbon receptor complex 2.988E-3 7.469E-3 2.850E-2
7.469E-2
 1 3
11 GO:0001651 dense fibrillar component 4.975E-3 1.131E-2 4.314E-2
1.244E-1
 1 5
Show 6 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 542 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 17 input genes in category / 1419 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0010716 optic disk coloboma 2.483E-11 3.523E-8 2.761E-7 3.523E-8 4 5
2 MP:0009527 abnormal sublingual duct morphology 7.441E-11 5.280E-8 4.137E-7 1.056E-7 4 6
3 MP:0008881 absent Harderian gland 3.466E-10 9.836E-8 7.707E-7 4.918E-7 4 8
4 MP:0010706 ventral rotation of lens 3.466E-10 9.836E-8 7.707E-7 4.918E-7 4 8
5 MP:0010584 abnormal conotruncus septation 3.466E-10 9.836E-8 7.707E-7 4.918E-7 4 8
6 MP:0001308 abnormal lens polarity 6.232E-10 1.474E-7 1.155E-6 8.843E-7 4 9
7 MP:0010711 persistent hyperplastic primary vitreous 1.629E-9 3.302E-7 2.587E-6 2.311E-6 4 11
8 MP:0009620 abnormal primary vitreous morphology 2.441E-9 3.849E-7 3.015E-6 3.464E-6 4 12
9 MP:0004035 abnormal sublingual gland morphology 2.441E-9 3.849E-7 3.015E-6 3.464E-6 4 12
10 MP:0010721 short sublingual duct 3.676E-9 4.742E-7 3.715E-6 5.216E-6 3 3
11 MP:0010989 fused bronchial cartilage rings 3.676E-9 4.742E-7 3.715E-6 5.216E-6 3 3
12 MP:0009517 abnormal salivary gland duct morphology 4.926E-9 5.825E-7 4.564E-6 6.990E-6 4 14
13 MP:0020486 abnormal lens topology 6.711E-9 7.325E-7 5.739E-6 9.523E-6 4 15
14 MP:0002258 abnormal cricoid cartilage morphology 1.168E-8 1.184E-6 9.274E-6 1.657E-5 4 17
15 MP:0010722 persistent cervical thymus 1.469E-8 1.303E-6 1.021E-5 2.084E-5 3 4
16 MP:0009438 cricoid and tracheal cartilage fusion 1.469E-8 1.303E-6 1.021E-5 2.084E-5 3 4
17 MP:0005248 abnormal Harderian gland morphology 1.898E-8 1.584E-6 1.241E-5 2.693E-5 4 19
18 MP:0010703 split cervical axis 3.668E-8 2.263E-6 1.773E-5 5.205E-5 3 5
19 MP:0009072 absent cranial vagina 3.668E-8 2.263E-6 1.773E-5 5.205E-5 3 5
20 MP:0009076 rudimentary Mullerian ducts 3.668E-8 2.263E-6 1.773E-5 5.205E-5 3 5
21 MP:0009077 abnormal cranial vagina morphology 3.668E-8 2.263E-6 1.773E-5 5.205E-5 3 5
22 MP:0003639 abnormal response to vitamins 3.668E-8 2.263E-6 1.773E-5 5.205E-5 3 5
23 MP:0010702 split cervical atlas 3.668E-8 2.263E-6 1.773E-5 5.205E-5 3 5
24 MP:0002672 abnormal pharyngeal arch artery morphology 4.149E-8 2.453E-6 1.922E-5 5.887E-5 5 63
25 MP:0001120 abnormal uterus morphology 5.407E-8 3.069E-6 2.405E-5 7.672E-5 7 241
26 MP:0002257 abnormal arytenoid cartilage morphology 7.329E-8 4.000E-6 3.134E-5 1.040E-4 3 6
27 MP:0010565 absent fetal ductus arteriosus 1.281E-7 6.269E-6 4.912E-5 1.818E-4 3 7
28 MP:0010710 absent sclera 1.281E-7 6.269E-6 4.912E-5 1.818E-4 3 7
29 MP:0010707 decreased ventral retina size 1.281E-7 6.269E-6 4.912E-5 1.818E-4 3 7
30 MP:0000678 abnormal parathyroid gland morphology 1.522E-7 6.968E-6 5.459E-5 2.160E-4 4 31
31 MP:0030310 abnormal cranial foramen morphology 1.522E-7 6.968E-6 5.459E-5 2.160E-4 4 31
32 MP:0008259 abnormal optic disk morphology 1.976E-7 8.303E-6 6.506E-5 2.803E-4 4 33
33 MP:0011486 ectopic ureter 2.048E-7 8.303E-6 6.506E-5 2.906E-4 3 8
34 MP:0010988 abnormal bronchial cartilage morphology 2.048E-7 8.303E-6 6.506E-5 2.906E-4 3 8
35 MP:0013574 ectopic parathyroid gland 2.048E-7 8.303E-6 6.506E-5 2.906E-4 3 8
36 MP:0010583 abnormal conotruncus morphology 2.237E-7 8.817E-6 6.908E-5 3.174E-4 4 34
37 MP:0003558 absent uterus 3.069E-7 1.177E-5 9.222E-5 4.355E-4 3 9
38 MP:0002256 abnormal laryngeal cartilage morphology 3.176E-7 1.186E-5 9.292E-5 4.507E-4 4 37
39 MP:0001154 seminiferous tubule degeneration 3.494E-7 1.271E-5 9.961E-5 4.958E-4 5 96
40 MP:0013227 small brain ventricles 4.380E-7 1.516E-5 1.188E-4 6.215E-4 3 10
41 MP:0001247 dermal cysts 4.380E-7 1.516E-5 1.188E-4 6.215E-4 3 10
42 MP:0005300 abnormal corneal stroma morphology 5.899E-7 1.940E-5 1.520E-4 8.370E-4 4 43
43 MP:0003792 abnormal major salivary gland morphology 5.899E-7 1.940E-5 1.520E-4 8.370E-4 4 43
44 MP:0010701 fusion of atlas and odontoid process 6.016E-7 1.940E-5 1.520E-4 8.536E-4 3 11
45 MP:0001849 ear inflammation 6.482E-7 2.044E-5 1.602E-4 9.198E-4 4 44
46 MP:0001286 abnormal eye development 6.892E-7 2.126E-5 1.666E-4 9.780E-4 7 350
47 MP:0005262 coloboma 7.776E-7 2.348E-5 1.840E-4 1.103E-3 4 46
48 MP:0002249 abnormal larynx morphology 9.254E-7 2.736E-5 2.143E-4 1.313E-3 4 48
49 MP:0010728 fusion of atlas and occipital bones 2.031E-6 5.883E-5 4.609E-4 2.883E-3 3 16
50 MP:0002698 abnormal sclera morphology 2.464E-6 6.110E-5 4.788E-4 3.497E-3 3 17
Show 45 more annotations

6: Domain [Display Chart] 19 input genes in category / 53 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001628 Znf hrmn rcpt InterPro 4.981E-28 4.400E-27 2.005E-26 2.640E-26 12 46
2 IPR001723 Nuclear hrmn rcpt InterPro 4.981E-28 4.400E-27 2.005E-26 2.640E-26 12 46
3 SM00399 ZnF C4 SMART 4.981E-28 4.400E-27 2.005E-26 2.640E-26 12 46
4 PS00031 NUCLEAR REC DBD 1 PROSITE 4.981E-28 4.400E-27 2.005E-26 2.640E-26 12 46
5 PF00105 zf-C4 Pfam 4.981E-28 4.400E-27 2.005E-26 2.640E-26 12 46
6 PS51030 NUCLEAR REC DBD 2 PROSITE 4.981E-28 4.400E-27 2.005E-26 2.640E-26 12 46
7 1.10.565.10 - Gene3D 6.686E-28 4.723E-27 2.152E-26 3.544E-26 12 47
8 IPR000536 Nucl hrmn rcpt lig-bd InterPro 8.912E-28 4.723E-27 2.152E-26 4.723E-26 12 48
9 SM00430 HOLI SMART 8.912E-28 4.723E-27 2.152E-26 4.723E-26 12 48
10 PF00104 Hormone recep Pfam 8.912E-28 4.723E-27 2.152E-26 4.723E-26 12 48
11 3.30.50.10 - Gene3D 9.020E-27 4.346E-26 1.980E-25 4.780E-25 12 57
12 IPR013088 Znf NHR/GATA InterPro 1.137E-26 5.021E-26 2.288E-25 6.025E-25 12 58
13 IPR000324 VitD rcpt InterPro 1.204E-12 4.909E-12 2.237E-11 6.382E-11 5 14
14 IPR003078 Retinoic acid rcpt InterPro 3.535E-9 1.338E-8 6.098E-8 1.873E-7 3 4
15 IPR001728 ThyrH rcpt InterPro 8.831E-9 3.120E-8 1.422E-7 4.681E-7 3 5
16 IPR000003 Retinoid-X rcpt/HNF4 InterPro 1.056E-7 3.499E-7 1.595E-6 5.599E-6 3 10
17 PF11825 Nuc recep-AF1 Pfam 9.744E-7 2.718E-6 1.239E-5 5.164E-5 2 2
18 IPR021780 Nuc recep-AF1 InterPro 9.744E-7 2.718E-6 1.239E-5 5.164E-5 2 2
19 IPR023257 Liver X rcpt InterPro 9.744E-7 2.718E-6 1.239E-5 5.164E-5 2 2
20 IPR033348 AHR InterPro 1.014E-3 2.443E-3 1.113E-2
5.375E-2
 1 1
21 IPR027294 NPS rcpt InterPro 1.014E-3 2.443E-3 1.113E-2
5.375E-2
 1 1
22 IPR002275 GPR1 orph rcpt InterPro 1.014E-3 2.443E-3 1.113E-2
5.375E-2
 1 1
23 IPR026780 PNRC1/2 InterPro 2.027E-3 4.672E-3 2.129E-2
1.074E-1
 1 2
24 IPR001817 Vasoprsn rcpt InterPro 5.061E-3 1.118E-2
5.093E-2
2.682E-1
 1 5
25 PF05920 Homeobox KN Pfam 1.711E-2 3.488E-2
1.589E-1
9.068E-1
 1 17
26 IPR008422 Homeobox KN domain InterPro 1.711E-2 3.488E-2
1.589E-1
9.068E-1
 1 17
27 PF08447 PAS 3 Pfam 2.308E-2 4.061E-2
1.851E-1
1.000E0
 1 23
28 IPR013655 PAS fold 3 InterPro 2.308E-2 4.061E-2
1.851E-1
1.000E0
 1 23
29 IPR000700 PAS-assoc C InterPro 2.407E-2 4.061E-2
1.851E-1
1.000E0
 1 24
30 IPR013767 PAS fold InterPro 2.506E-2 4.061E-2
1.851E-1
1.000E0
 1 25
31 PF00989 PAS Pfam 2.506E-2 4.061E-2
1.851E-1
1.000E0
 1 25
32 IPR001610 PAC InterPro 2.605E-2 4.061E-2
1.851E-1
1.000E0
 1 26
33 PS50113 PAC PROSITE 2.605E-2 4.061E-2
1.851E-1
1.000E0
 1 26
34 SM00086 PAC SMART 2.605E-2 4.061E-2
1.851E-1
1.000E0
 1 26
35 SM00091 PAS SMART 3.197E-2 4.842E-2
2.206E-1
1.000E0
 1 32
36 PS50112 PAS PROSITE 3.394E-2 4.862E-2
2.215E-1
1.000E0
 1 34
37 IPR000014 PAS InterPro 3.394E-2 4.862E-2
2.215E-1
1.000E0
 1 34
Show 32 more annotations

7: Pathway [Display Chart] 15 input genes in category / 84 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269652 Nuclear Receptor transcription pathway BioSystems: REACTOME 2.486E-27 2.089E-25 1.047E-24 2.089E-25 12 51
2 1269630 Signaling by Retinoic Acid BioSystems: REACTOME 5.772E-12 2.424E-10 1.216E-9 4.849E-10 6 43
3 137975 RXR and RAR heterodimerization with other nuclear receptor BioSystems: Pathway Interaction Database 1.356E-9 3.797E-8 1.904E-7 1.139E-7 4 14
4 M16393 Nuclear Receptors in Lipid Metabolism and Toxicity MSigDB C2 BIOCARTA (v6.0) 1.848E-9 3.880E-8 1.945E-7 1.552E-7 4 15
5 138039 Retinoic acid receptors-mediated signaling BioSystems: Pathway Interaction Database 1.700E-8 2.856E-7 1.432E-6 1.428E-6 4 25
6 1469482 Th17 cell differentiation BioSystems: KEGG 1.197E-7 1.676E-6 8.402E-6 1.005E-5 5 107
7 83119 Non-small cell lung cancer BioSystems: KEGG 5.571E-7 6.685E-6 3.352E-5 4.679E-5 4 58
8 83042 PPAR signaling pathway BioSystems: KEGG 1.337E-6 1.404E-5 7.041E-5 1.123E-4 4 72
9 83118 Small cell lung cancer BioSystems: KEGG 2.487E-6 2.321E-5 1.164E-4 2.089E-4 4 84
10 1270192 Endogenous sterols BioSystems: REACTOME 4.552E-6 3.824E-5 1.917E-4 3.824E-4 3 28
11 83112 Thyroid cancer BioSystems: KEGG 5.074E-6 3.875E-5 1.943E-4 4.262E-4 3 29
12 1339140 Activation of anterior HOX genes in hindbrain development during early embryogenesis BioSystems: REACTOME 1.292E-5 8.349E-5 4.186E-4 1.085E-3 4 127
13 1339139 Activation of HOX genes during differentiation BioSystems: REACTOME 1.292E-5 8.349E-5 4.186E-4 1.085E-3 4 127
14 P04396 Vitamin D metabolism and pathway PantherDB 4.854E-5 2.852E-4 1.430E-3 4.077E-3 2 9
15 523016 Transcriptional misregulation in cancer BioSystems: KEGG 5.093E-5 2.852E-4 1.430E-3 4.278E-3 4 180
16 83093 Adipocytokine signaling pathway BioSystems: KEGG 7.068E-5 3.274E-4 1.642E-3 5.937E-3 3 69
17 83105 Pathways in cancer BioSystems: KEGG 7.235E-5 3.274E-4 1.642E-3 6.078E-3 5 395
18 1270191 Cytochrome P450 - arranged by substrate type BioSystems: REACTOME 7.379E-5 3.274E-4 1.642E-3 6.198E-3 3 70
19 M18837 Map Kinase Inactivation of SMRT Corepressor MSigDB C2 BIOCARTA (v6.0) 7.406E-5 3.274E-4 1.642E-3 6.221E-3 2 11
20 1427853 VLDLR internalisation and degradation BioSystems: REACTOME 8.880E-5 3.730E-4 1.870E-3 7.460E-3 2 12
21 M7968 Transcription Regulation by Methyltransferase of CARM1 MSigDB C2 BIOCARTA (v6.0) 1.049E-4 4.195E-4 2.103E-3 8.810E-3 2 13
22 1270044 Synthesis of bile acids and bile salts via 27-hydroxycholesterol BioSystems: REACTOME 1.410E-4 5.149E-4 2.582E-3 1.184E-2 2 15
23 M6907 Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells MSigDB C2 BIOCARTA (v6.0) 1.410E-4 5.149E-4 2.582E-3 1.184E-2 2 15
24 1270045 Recycling of bile acids and salts BioSystems: REACTOME 1.610E-4 5.635E-4 2.826E-3 1.353E-2 2 16
25 1270190 Phase 1 - Functionalization of compounds BioSystems: REACTOME 2.903E-4 9.753E-4 4.890E-3 2.438E-2 3 111
26 946598 Thyroid hormone signaling pathway BioSystems: KEGG 3.305E-4 1.051E-3 5.270E-3 2.776E-2 3 116
27 1427851 VLDL interactions BioSystems: REACTOME 3.378E-4 1.051E-3 5.270E-3 2.838E-2 2 23
28 1270042 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol BioSystems: REACTOME 3.683E-4 1.105E-3 5.540E-3 3.094E-2 2 24
29 1270030 PPARA activates gene expression BioSystems: REACTOME 4.020E-4 1.164E-3 5.839E-3 3.377E-2 3 124
30 1270029 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BioSystems: REACTOME 4.312E-4 1.207E-3 6.054E-3 3.622E-2 3 127
31 1270041 Synthesis of bile acids and bile salts BioSystems: REACTOME 7.434E-4 2.014E-3 1.010E-2
6.244E-2
 2 34
32 1270040 Bile acid and bile salt metabolism BioSystems: REACTOME 1.189E-3 3.121E-3 1.565E-2
9.988E-2
 2 43
33 M2404 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) MSigDB C2 BIOCARTA (v6.0) 2.154E-3 5.483E-3 2.749E-2
1.809E-1
 2 58
34 1270189 Biological oxidations BioSystems: REACTOME 2.373E-3 5.863E-3 2.939E-2
1.993E-1
 3 229
35 1270010 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 3.149E-3 7.488E-3 3.754E-2
2.645E-1
 3 253
36 193146 Bile secretion BioSystems: KEGG 3.209E-3 7.488E-3 3.754E-2
2.696E-1
 2 71
37 1270005 Lipoprotein metabolism BioSystems: REACTOME 3.481E-3 7.776E-3 3.899E-2
2.924E-1
 2 74
38 P06664 Gonadotropin-releasing hormone receptor pathway PantherDB 3.610E-3 7.776E-3 3.899E-2
3.033E-1
 1 3
39 PW:0000370 the XRE-AhR mediated of drug-metabolizing enzyme expression Pathway Ontology 3.610E-3 7.776E-3 3.899E-2
3.033E-1
 1 3
40 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 3.763E-3 7.902E-3 3.962E-2
3.161E-1
 2 77
41 1272486 Insulin resistance BioSystems: KEGG 7.143E-3 1.463E-2
7.337E-2
6.000E-1
 2 107
42 1270002 Lipid digestion, mobilization, and transport BioSystems: REACTOME 8.210E-3 1.642E-2
8.233E-2
6.897E-1
 2 115
43 1470921 Aryl hydrocarbon receptor signalling BioSystems: REACTOME 9.601E-3 1.875E-2
9.404E-2
8.065E-1
 1 8
44 173973 Hepatitis C BioSystems: KEGG 1.055E-2 2.014E-2
1.010E-1
8.860E-1
 2 131
45 SMP00383 Obesity / Metabolic Syndrome SMPDB 1.079E-2 2.015E-2
1.010E-1
9.068E-1
 1 9
46 1270014 Import of palmitoyl-CoA into the mitochondrial matrix BioSystems: REACTOME 1.318E-2 2.407E-2
1.207E-1
1.000E0
 1 11
47 862188 Non-alcoholic fatty liver disease (NAFLD) BioSystems: KEGG 1.349E-2 2.411E-2
1.209E-1
1.000E0
 2 149
48 M13404 Control of Gene Expression by Vitamin D Receptor MSigDB C2 BIOCARTA (v6.0) 1.437E-2 2.515E-2
1.261E-1
1.000E0
 1 12
49 1270124 Regulation of pyruvate dehydrogenase (PDH) complex BioSystems: REACTOME 1.674E-2 2.871E-2
1.439E-1
1.000E0
 1 14
50 M4891 Regulation of transcriptional activity by PML MSigDB C2 BIOCARTA (v6.0) 2.030E-2 3.410E-2
1.710E-1
1.000E0
 1 17
Show 45 more annotations

8: Pubmed [Display Chart] 19 input genes in category / 6889 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15604093 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Pubmed 1.614E-28 1.112E-24 1.047E-23 1.112E-24 13 133
2 10094571 Retinoids and adipose tissues: metabolism, cell differentiation and gene expression. Pubmed 1.714E-23 5.905E-20 5.559E-19 1.181E-19 7 8
3 16971476 A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Pubmed 2.563E-21 3.337E-18 3.141E-17 1.766E-17 10 111
4 9548551 Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
5 8801176 A decade of molecular biology of retinoic acid receptors. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
6 11328745 Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
7 8801169 RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
8 9075714 Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
9 9806918 The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
10 9464546 Functional specificity of the two retinoic acid receptor RAR and RXR families in myogenesis. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
11 9153406 The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
12 10604193 A genetic dissection of the retinoid signalling pathway in the mouse. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
13 20557428 Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid. Pubmed 6.296E-21 3.337E-18 3.141E-17 4.337E-17 6 6
14 20932939 Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Pubmed 3.979E-20 1.518E-17 1.429E-16 2.741E-16 11 243
15 17195188 Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Pubmed 4.406E-20 1.518E-17 1.429E-16 3.035E-16 6 7
16 17124491 Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. Pubmed 4.406E-20 1.518E-17 1.429E-16 3.035E-16 6 7
17 8090775 Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression. Pubmed 4.406E-20 1.518E-17 1.429E-16 3.035E-16 6 7
18 12360493 Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions. Pubmed 4.406E-20 1.518E-17 1.429E-16 3.035E-16 6 7
19 11493527 Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha. Pubmed 4.406E-20 1.518E-17 1.429E-16 3.035E-16 6 7
20 15635645 Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. Pubmed 4.406E-20 1.518E-17 1.429E-16 3.035E-16 6 7
21 7988794 Expression of nuclear retinoic acid receptors during mouse odontogenesis. Pubmed 1.762E-19 5.780E-17 5.442E-16 1.214E-15 6 8
22 20375256 Nuclear receptors in Leydig cell gene expression and function. Pubmed 3.640E-19 1.140E-16 1.073E-15 2.508E-15 7 22
23 29093497 Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter. Pubmed 1.321E-18 3.956E-16 3.724E-15 9.098E-15 6 10
24 9022057 Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Pubmed 5.808E-18 1.667E-15 1.569E-14 4.001E-14 6 12
25 19345331 ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Pubmed 1.717E-17 4.061E-15 3.823E-14 1.183E-13 5 5
26 9053308 Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Pubmed 1.717E-17 4.061E-15 3.823E-14 1.183E-13 5 5
27 8199055 Developmental expression of murine retinoid X receptor (RXR) genes. Pubmed 1.717E-17 4.061E-15 3.823E-14 1.183E-13 5 5
28 10452855 Retinoic acid signaling is necessary for the development of the organ of Corti. Pubmed 1.717E-17 4.061E-15 3.823E-14 1.183E-13 5 5
29 18561907 Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Pubmed 1.886E-17 4.061E-15 3.823E-14 1.300E-13 6 14
30 21923909 LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes. Pubmed 1.886E-17 4.061E-15 3.823E-14 1.300E-13 6 14
31 19448158 Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia. Pubmed 1.886E-17 4.061E-15 3.823E-14 1.300E-13 6 14
32 18393306 Retinoic acid induces prostatic bud formation. Pubmed 1.886E-17 4.061E-15 3.823E-14 1.300E-13 6 14
33 11795391 External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium. Pubmed 3.143E-17 6.561E-15 6.177E-14 2.165E-13 6 15
34 16428452 TGIF inhibits retinoid signaling. Pubmed 1.030E-16 2.087E-14 1.965E-13 7.097E-13 5 6
35 19605690 Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Pubmed 1.165E-16 2.293E-14 2.158E-13 8.024E-13 6 18
36 10753524 Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Pubmed 2.430E-16 4.651E-14 4.379E-13 1.674E-12 6 20
37 9428411 Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Pubmed 3.604E-16 6.711E-14 6.318E-13 2.483E-12 5 7
38 19737349 Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Pubmed 6.324E-16 1.147E-13 1.079E-12 4.357E-12 6 23
39 10490294 Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. Pubmed 9.609E-16 1.655E-13 1.558E-12 6.620E-12 5 8
40 7823919 A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Pubmed 9.609E-16 1.655E-13 1.558E-12 6.620E-12 5 8
41 27445154 Diverse Functions of Retinoic Acid in Brain Vascular Development. Pubmed 1.852E-15 3.112E-13 2.930E-12 1.276E-11 6 27
42 17270348 Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. Pubmed 3.712E-15 6.089E-13 5.733E-12 2.558E-11 6 30
43 16219912 Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Pubmed 1.357E-14 2.175E-12 2.047E-11 9.350E-11 5 12
44 19902255 Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. Pubmed 3.429E-14 5.369E-12 5.054E-11 2.362E-10 5 14
45 10079186 Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice. Pubmed 4.372E-14 5.683E-12 5.351E-11 3.012E-10 4 4
46 12093741 Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled. Pubmed 4.372E-14 5.683E-12 5.351E-11 3.012E-10 4 4
47 8524212 Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand. Pubmed 4.372E-14 5.683E-12 5.351E-11 3.012E-10 4 4
48 26355550 Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression. Pubmed 4.372E-14 5.683E-12 5.351E-11 3.012E-10 4 4
49 1310259 Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Pubmed 4.372E-14 5.683E-12 5.351E-11 3.012E-10 4 4
50 9376317 Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. Pubmed 4.372E-14 5.683E-12 5.351E-11 3.012E-10 4 4
Show 45 more annotations

9: Interaction [Display Chart] 18 input genes in category / 533 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RXRG RXRG interactions 3.653E-29 1.947E-26 1.335E-25 1.947E-26 12 39
2 int:NCOA1 NCOA1 interactions 6.271E-23 1.671E-20 1.146E-19 3.343E-20 12 116
3 int:RXRA RXRA interactions 8.587E-22 1.526E-19 1.046E-18 4.577E-19 12 143
4 int:RXRB RXRB interactions 3.889E-21 5.182E-19 3.553E-18 2.073E-18 10 60
5 int:NR0B2 NR0B2 interactions 4.891E-20 5.214E-18 3.575E-17 2.607E-17 10 76
6 int:NCOR2 NCOR2 interactions 1.018E-19 9.048E-18 6.204E-17 5.429E-17 11 135
7 int:NCOA3 NCOA3 interactions 3.915E-19 2.981E-17 2.044E-16 2.086E-16 11 152
8 int:RARA RARA interactions 3.155E-16 2.102E-14 1.441E-13 1.682E-13 10 177
9 int:RARB RARB interactions 7.800E-15 4.520E-13 3.099E-12 4.158E-12 7 42
10 int:NCOA6 NCOA6 interactions 8.481E-15 4.520E-13 3.099E-12 4.520E-12 8 85
11 int:RARG RARG interactions 1.310E-14 6.347E-13 4.352E-12 6.982E-12 7 45
12 int:NCOR1 NCOR1 interactions 6.988E-14 3.104E-12 2.128E-11 3.725E-11 9 190
13 int:NRIP1 NRIP1 interactions 3.414E-13 1.400E-11 9.596E-11 1.819E-10 7 70
14 int:NR1H2 NR1H2 interactions 1.899E-11 7.229E-10 4.957E-9 1.012E-8 6 59
15 int:NR1H4 NR1H4 interactions 5.733E-11 2.037E-9 1.397E-8 3.056E-8 5 28
16 int:PSMC5 PSMC5 interactions 8.463E-11 2.819E-9 1.933E-8 4.511E-8 8 264
17 int:TGIF1 TGIF1 interactions 1.172E-10 3.674E-9 2.519E-8 6.246E-8 5 32
18 int:NCOA2 NCOA2 interactions 3.149E-10 9.325E-9 6.394E-8 1.678E-7 6 93
19 int:NR1H3 NR1H3 interactions 1.098E-9 3.081E-8 2.112E-7 5.853E-7 5 49
20 int:SMARCD3 SMARCD3 interactions 1.649E-9 4.394E-8 3.013E-7 8.787E-7 5 53
21 int:MED1 MED1 interactions 2.301E-9 5.840E-8 4.005E-7 1.226E-6 6 129
22 int:NR2E3 NR2E3 interactions 2.872E-9 6.958E-8 4.771E-7 1.531E-6 4 19
23 int:VDR VDR interactions 4.877E-8 1.130E-6 7.750E-6 2.600E-5 5 103
24 int:NR1I2 NR1I2 interactions 6.682E-8 1.484E-6 1.017E-5 3.561E-5 4 40
25 int:PPARA PPARA interactions 2.658E-7 5.667E-6 3.886E-5 1.417E-4 4 56
26 int:PPARG PPARG interactions 3.892E-7 7.867E-6 5.394E-5 2.074E-4 5 156
27 int:HACE1 HACE1 interactions 3.985E-7 7.867E-6 5.394E-5 2.124E-4 3 15
28 int:ITGB1BP2 ITGB1BP2 interactions 4.902E-7 9.010E-6 6.178E-5 2.613E-4 3 16
29 int:HR HR interactions 4.902E-7 9.010E-6 6.178E-5 2.613E-4 3 16
30 int:POU1F1 POU1F1 interactions 5.949E-7 1.057E-5 7.247E-5 3.171E-4 3 17
31 int:PNRC1 PNRC1 interactions 8.466E-7 1.456E-5 9.981E-5 4.512E-4 3 19
32 int:PPARGC1A PPARGC1A interactions 9.169E-7 1.527E-5 1.047E-4 4.887E-4 4 76
33 int:TADA3 TADA3 interactions 9.665E-7 1.561E-5 1.070E-4 5.151E-4 4 77
34 int:DNMT3L DNMT3L interactions 1.508E-6 2.364E-5 1.621E-4 8.038E-4 4 86
35 int:HNF4A HNF4A interactions 1.810E-6 2.756E-5 1.890E-4 9.647E-4 4 90
36 int:NR5A2 NR5A2 interactions 2.846E-6 4.100E-5 2.811E-4 1.517E-3 3 28
37 int:NR2F6 NR2F6 interactions 2.846E-6 4.100E-5 2.811E-4 1.517E-3 3 28
38 int:AJUBA AJUBA interactions 5.179E-6 7.264E-5 4.980E-4 2.760E-3 3 34
39 int:SIRT1 SIRT1 interactions 5.385E-6 7.360E-5 5.046E-4 2.870E-3 5 266
40 int:NR1I3 NR1I3 interactions 7.884E-6 1.051E-4 7.203E-4 4.202E-3 3 39
41 int:TAF11 TAF11 interactions 1.139E-5 1.481E-4 1.015E-3 6.070E-3 3 44
42 int:NSD1 NSD1 interactions 1.392E-5 1.766E-4 1.211E-3 7.418E-3 3 47
43 int:TDG TDG interactions 1.484E-5 1.839E-4 1.261E-3 7.907E-3 3 48
44 int:PPARD PPARD interactions 2.240E-5 2.714E-4 1.861E-3 1.194E-2 3 55
45 int:GRIP1 GRIP1 interactions 2.495E-5 2.956E-4 2.027E-3 1.330E-2 3 57
46 int:MED6 MED6 interactions 2.769E-5 3.208E-4 2.200E-3 1.476E-2 3 59
47 int:SRC SRC interactions 4.096E-5 4.645E-4 3.185E-3 2.183E-2 5 405
48 int:ARNTL ARNTL interactions 4.630E-5 5.141E-4 3.525E-3 2.468E-2 3 70
49 int:STAT1 STAT1 interactions 4.979E-5 5.416E-4 3.713E-3 2.654E-2 4 208
50 int:CEBPA CEBPA interactions 5.362E-5 5.716E-4 3.920E-3 2.858E-2 4 212
Show 45 more annotations

10: Cytoband [Display Chart] 19 input genes in category / 19 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q12-q13.3 3q12-q13.3 1.096E-3 2.082E-2
7.388E-2
 2.082E-2 1 2
2 16q12 16q12 3.285E-3 3.120E-2
1.107E-1
6.241E-2
 1 6
3 18p11.3 18p11.3 6.014E-3 3.192E-2
1.132E-1
1.143E-1
 1 11
4 1q22-q23 1q22-q23 7.104E-3 3.192E-2
1.132E-1
1.350E-1
 1 13
5 7p15 7p15 8.737E-3 3.192E-2
1.132E-1
1.660E-1
 1 16
6 3p24.2 3p24.2 1.037E-2 3.192E-2
1.132E-1
1.970E-1
 1 19
7 2q33.3 2q33.3 1.686E-2 3.192E-2
1.132E-1
3.204E-1
 1 31
8 6q15 6q15 1.794E-2 3.192E-2
1.132E-1
3.409E-1
 1 33
9 12q23.1 12q23.1 1.848E-2 3.192E-2
1.132E-1
3.511E-1
 1 34
10 12q13.11 12q13.11 1.848E-2 3.192E-2
1.132E-1
3.511E-1
 1 34
11 22q12.1 22q12.1 1.848E-2 3.192E-2
1.132E-1
3.511E-1
 1 34
12 7p14.3 7p14.3 2.117E-2 3.352E-2
1.189E-1
4.022E-1
 1 39
13 1q23.3 1q23.3 2.760E-2 4.033E-2
1.431E-1
5.243E-1
 1 51
14 17q21 17q21 3.398E-2 4.612E-2
1.636E-1
6.457E-1
 1 63
15 12q13 12q13 3.822E-2 4.841E-2
1.718E-1
7.262E-1
 1 71
Show 10 more annotations

11: Transcription Factor Binding Site [Display Chart] 16 input genes in category / 236 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 17 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 71 Nuclear hormone receptors genenames.org 2.067E-28 1.240E-27 3.038E-27 1.240E-27 12 49
2 854 Neuropeptide receptors genenames.org 9.307E-3 2.792E-2
6.841E-2
5.584E-2
 1 10
3 526 TALE class homeoboxes and pseudogenes genenames.org 2.403E-2 4.806E-2
1.177E-1
1.442E-1
 1 26

13: Coexpression [Display Chart] 19 input genes in category / 1917 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15525570-SuppTable1 Human Ovarian Rae04 209genes GeneSigDB 6.474E-19 9.109E-16 7.411E-15 1.241E-15 11 191
2 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 9.503E-19 9.109E-16 7.411E-15 1.822E-15 12 303
3 18689800-TableS6 Human EmbryonicStemCell Thomas08 113genes GeneSigDB 2.558E-8 1.634E-5 1.330E-4 4.903E-5 5 111
4 20188076-Table1 Human Leukemia Nath10 26genes GeneSigDB 1.206E-6 5.120E-4 4.165E-3 2.312E-3 3 26
5 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 1.335E-6 5.120E-4 4.165E-3 2.560E-3 6 462
6 M10861 Genes affected by epigenetic aberrations in prostate cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.880E-6 5.222E-4 4.248E-3 3.603E-3 3 30
7 M5948 Genes involve in metabolism of bile acids and salts. MSigDB H: Hallmark Gene Sets (v6.0) 1.907E-6 5.222E-4 4.248E-3 3.655E-3 4 112
8 15867264-Table2 Human pancreas Segara05 38genes GeneSigDB 3.022E-6 7.242E-4 5.892E-3 5.793E-3 3 35
9 18221535-Table2 Human Liver Parent08 55genes GeneSigDB 3.584E-6 7.634E-4 6.211E-3 6.871E-3 3 37
10 M3282 Genes up-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 3 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 1.683E-5 3.226E-3 2.625E-2 3.226E-2 4 194
11 M9206 Genes down-regulated in hepatocellular carcinoma (HCC) cells with hepatic stem cell properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.178E-5 5.538E-3 4.506E-2
6.092E-2
 3 76
12 M2339 Direct targets of PRDM5 [GeneID=11107]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.569E-5 5.701E-3 4.639E-2
6.842E-2
 3 79
13 M1645 Adipocyte genes induced in 3T3-L1 cells (adipocyte) by constitutively active PPARG [GeneID=5468] or its agonist, TZD [PubChem=5437]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.625E-5 1.272E-2
1.035E-1
1.653E-1
 2 17
14 M2250 Up-regulated genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.241E-4 1.699E-2
1.382E-1
2.379E-1
 3 120
15 M581 Genes up-regulated in MS427 cells (Wilms tumor with normal WT1 [GeneID=7490]) after treatment with 10 microM tretinoin (ATRA) [PubChem=444795] for 24 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.329E-4 1.699E-2
1.382E-1
2.548E-1
 2 21
16 16651414-Supp4 Human Breast Bertucci06 527genes GeneSigDB 1.779E-4 2.132E-2
1.734E-1
3.411E-1
 4 356
17 19658189-TableS8b Human EmbryonicStemCell Xu09 26genes GeneSigDB 2.052E-4 2.314E-2
1.883E-1
3.934E-1
 2 26
18 M5091 A gene expression signature found in a subset of cancer patients suggestive of a deregulated immune or inflammatory response. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.215E-4 2.359E-2
1.919E-1
4.247E-1
 2 27
19 M7116 Genes up-regulated in CD4 [GeneID=920] T cells: control versus treated with halofuginone [PubChem=400772] for 3h. MSigDB C7: Immunologic Signatures (v6.0) 2.691E-4 2.611E-2
2.124E-1
5.159E-1
 3 156
20 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 2.724E-4 2.611E-2
2.124E-1
5.222E-1
 4 398
21 M341 Genes down-regulated in tracheal epithelial cells infected with UV inactivated versus intact Sendai virus. MSigDB C7: Immunologic Signatures (v6.0) 2.953E-4 2.672E-2
2.174E-1
5.660E-1
 3 161
22 16007187-GeneList Human Breast Einav05 34genes GeneSigDB 3.123E-4 2.672E-2
2.174E-1
5.986E-1
 2 32
23 M17163 Genes up-regulated at early fetal liver stage (embryonic days E11.5 - E12.5) compared to the late fetal liver stage (embryonic days E14.5 - E16.5). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.230E-4 2.672E-2
2.174E-1
6.191E-1
 3 166
24 19286929-SuppTable2i Mouse Lung Rangasamy09 248genes GeneSigDB 3.345E-4 2.672E-2
2.174E-1
6.413E-1
 3 168
25 M8537 Genes down-regulated in lymph nodes from patients with mantle cell lymphoma (MCL) compared to the non-malignant hyperplastic lymph nodes. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.649E-4 2.884E-2
2.347E-1
8.913E-1
 2 39
26 12130493-Table6 Mouse StemCell Ma02 42genes GeneSigDB 5.140E-4 2.884E-2
2.347E-1
9.853E-1
 2 41
27 M5197 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to 50 worm/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.884E-2
2.347E-1
1.000E0
 3 199
28 M9077 Genes up-regulated in the bone marrow CD34+ [GeneID=947] cells: CD38- [GeneID=952] versus MME+ [GeneID=4311]. MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.884E-2
2.347E-1
1.000E0
 3 199
29 M7651 Genes down-regulated in CD4 [GeneID=920] T cells under specific pathogen free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.884E-2
2.347E-1
1.000E0
 3 199
30 M5420 Genes up-regulated in comparison of eosinophils versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.884E-2
2.347E-1
1.000E0
 3 199
31 M7986 Genes up-regulated in macrophages (12h): rosiglitazone [PubChem=77999] and IL4 [GeneID=3565] versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
32 M5144 Genes down-regulated in untreated dendritic cells (DC) versus DCs exposed to parasite L. donovani. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
33 M9207 Genes down-regulated in CD8 T cells: wildtype versus STAT1 [GeneID=6772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
34 M8647 Genes down-regulated in bone marrow-derived macrophages: wildtype versus NFAT5 [GeneID=10725] knockout. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
35 M7962 Genes up-regulated in wildtype bone marrow-derived macrophages treated with IL4 [GeneID=3565]: control versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
36 M7283 Genes up-regulated in monocytes after HCMV infection: untreated versus pre-treated with Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
37 M4963 Genes up-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.884E-2
2.347E-1
1.000E0
 3 200
38 M25 Genes up-regulated in the temporal cortex samples from patients with major depressive disorder. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.342E-4 3.704E-2
3.014E-1
1.000E0
 2 49
39 17096850-Table2 Human Lung Balko06 50genes GeneSigDB 7.645E-4 3.758E-2
3.057E-1
1.000E0
 2 50
40 14583454-TableS1 Human Brain Godard03 239genes GeneSigDB 7.939E-4 3.805E-2
3.095E-1
1.000E0
 3 226
41 M2567 Genes down-regulated in T98 cells (glioma) 48 h after treatment with interferon beta. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.267E-4 3.865E-2
3.145E-1
1.000E0
 2 52
42 M9806 Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 8.587E-4 3.919E-2
3.189E-1
1.000E0
 2 53
43 M8897 Down-regulated genes whose expression correlates with copy number losses in pancreatic adenocarcinoma cell lines and primary tumor specimens. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.109E-4 4.061E-2
3.304E-1
1.000E0
 3 237
44 M2123 Up-regulated genes in the cancer gene signature, representing a gene signature of cellular transformation. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.675E-4 4.215E-2
3.430E-1
1.000E0
 3 242
45 M3447 Genes whose expression peaked at 60 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.926E-4 4.228E-2
3.440E-1
1.000E0
 2 57
46 19061838-TableS12 Human Viral Cairo08 61genes GeneSigDB 1.063E-3 4.430E-2
3.604E-1
1.000E0
 2 59
47 M7899 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and tBH [PubChem=5283344;6410]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.099E-3 4.483E-2
3.648E-1
1.000E0
 2 60
Show 42 more annotations

14: Coexpression Atlas [Display Chart] 19 input genes in category / 987 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 JC iEC 2500 K4 JC iEC top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 1.519E-5 1.499E-2
1.120E-1
 1.499E-2 5 382

15: Computational [Display Chart] 17 input genes in category / 111 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.668E-5 1.852E-3 9.799E-3 1.852E-3 6 355
2 M11630 MODULE 404 Steroid hormone receptors and binding proteins. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.568E-4 4.755E-2
2.516E-1
9.511E-2
 2 26

16: MicroRNA [Display Chart] 19 input genes in category / 731 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-622:PITA hsa-miR-622:PITA TOP PITA 3.674E-5 4.877E-3 3.498E-2 2.686E-2 3 247
2 hsa-miR-548am-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.976E-5 4.877E-3 3.498E-2 4.368E-2 3 291
3 hsa-miR-548ah-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.976E-5 4.877E-3 3.498E-2 4.368E-2 3 291
4 hsa-miR-548j-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.037E-5 4.877E-3 3.498E-2 4.413E-2 3 292
5 hsa-miR-548aq-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.098E-5 4.877E-3 3.498E-2 4.458E-2 3 293
6 hsa-miR-548ae-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.098E-5 4.877E-3 3.498E-2 4.458E-2 3 293
7 hsa-miR-548x-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.098E-5 4.877E-3 3.498E-2 4.458E-2 3 293
8 hsa-miR-548aj-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.098E-5 4.877E-3 3.498E-2 4.458E-2 3 293
9 hsa-miR-5196-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.868E-5 4.877E-3 3.498E-2
5.020E-2
 3 305
10 hsa-miR-4747-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.868E-5 4.877E-3 3.498E-2
5.020E-2
 3 305
11 hsa-miR-6735-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.339E-5 4.877E-3 3.498E-2
5.365E-2
 2 48
12 hsa-miR-219a-5p:TargetScan hsa-miR-219a-5p TargetScan 8.983E-5 5.472E-3 3.925E-2
6.567E-2
 3 334
13 hsa-miR-320e:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.188E-4 6.548E-3 4.697E-2
8.686E-2
 2 61
14 hsa-miR-4731-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.254E-4 6.548E-3 4.697E-2
9.168E-2
 3 374
15 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 1.506E-4 7.340E-3
5.264E-2
1.101E-1
 3 398
16 hsa-miR-4296:mirSVR highEffct hsa-miR-4296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.063E-4 9.168E-3
6.576E-2
1.508E-1
 3 443
17 hsa-miR-4265:mirSVR highEffct hsa-miR-4265:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.132E-4 9.168E-3
6.576E-2
1.559E-1
 3 448
18 hsa-miR-4322:mirSVR highEffct hsa-miR-4322:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.454E-4 9.714E-3
6.967E-2
1.794E-1
 3 470
19 hsa-miR-939:PITA hsa-miR-939:PITA TOP PITA 2.589E-4 9.714E-3
6.967E-2
1.892E-1
 2 90
20 hsa-miR-520f-3p:TargetScan hsa-miR-520f-3p TargetScan 2.805E-4 9.714E-3
6.967E-2
2.051E-1
 3 492
21 hsa-miR-302c-3p.2:TargetScan hsa-miR-302c-3p.2 TargetScan 2.805E-4 9.714E-3
6.967E-2
2.051E-1
 3 492
22 hsa-miR-490-3p:mirSVR highEffct hsa-miR-490-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 2.923E-4 9.714E-3
6.967E-2
2.137E-1
 3 499
23 hsa-miR-299-3p:PITA hsa-miR-299-3p:PITA TOP PITA 3.793E-4 1.206E-2
8.647E-2
2.773E-1
 2 109
24 hsa-miR-4307:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.148E-4 1.263E-2
9.061E-2
3.032E-1
 2 114
25 hsa-miR-545-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.442E-4 1.299E-2
9.316E-2
3.247E-1
 2 118
26 hsa-miR-328:PITA hsa-miR-328:PITA TOP PITA 5.061E-4 1.329E-2
9.531E-2
3.700E-1
 2 126
27 hsa-miR-3692-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.142E-4 1.329E-2
9.531E-2
3.758E-1
 2 127
28 hsa-miR-768-5p:PITA hsa-miR-768-5p:PITA TOP PITA 5.386E-4 1.329E-2
9.531E-2
3.937E-1
 2 130
29 hsa-miR-556-5p:PITA hsa-miR-556-5p:PITA TOP PITA 5.468E-4 1.329E-2
9.531E-2
3.997E-1
 2 131
30 hsa-miR-194-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-4 1.329E-2
9.531E-2
4.058E-1
 2 132
31 hsa-miR-1275:PITA hsa-miR-1275:PITA TOP PITA 5.636E-4 1.329E-2
9.531E-2
4.120E-1
 2 133
32 hsa-miR-412:PITA hsa-miR-412:PITA TOP PITA 6.329E-4 1.446E-2
1.037E-1
4.626E-1
 2 141
33 hsa-miR-574-3p:mirSVR highEffct hsa-miR-574-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.690E-4 1.482E-2
1.063E-1
4.890E-1
 2 145
34 hsa-miR-578:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.155E-4 1.511E-2
1.084E-1
5.231E-1
 2 150
35 hsa-miR-512-5p:PITA hsa-miR-512-5p:PITA TOP PITA 7.346E-4 1.511E-2
1.084E-1
5.370E-1
 2 152
36 hsa-miR-7854-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.442E-4 1.511E-2
1.084E-1
5.440E-1
 2 153
37 hsa-miR-6783-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.095E-3 2.154E-2
1.545E-1
8.008E-1
 2 186
38 GTATTAT,MIR-369-3P:MSigDB GTATTAT,MIR-369-3P:MSigDB MSigDB 1.142E-3 2.154E-2
1.545E-1
8.352E-1
 2 190
39 hsa-miR-6778-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.166E-3 2.154E-2
1.545E-1
8.526E-1
 2 192
40 ATACTGT,MIR-144:MSigDB ATACTGT,MIR-144:MSigDB MSigDB 1.178E-3 2.154E-2
1.545E-1
8.614E-1
 2 193
41 hsa-miR-1233-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.227E-3 2.188E-2
1.569E-1
8.970E-1
 2 197
42 hsa-miR-1250-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.353E-3 2.355E-2
1.689E-1
9.891E-1
 2 207
43 hsa-miR-3667-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.595E-3 2.711E-2
1.944E-1
1.000E0
 2 225
44 hsa-miR-876-5p:TargetScan hsa-miR-876-5p TargetScan 1.651E-3 2.743E-2
1.967E-1
1.000E0
 2 229
45 hsa-miR-297:PITA hsa-miR-297:PITA TOP PITA 1.723E-3 2.798E-2
2.007E-1
1.000E0
 2 234
46 hsa-miR-3148:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.871E-3 2.901E-2
2.081E-1
1.000E0
 2 244
47 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 2.184E-3 2.901E-2
2.081E-1
1.000E0
 2 264
48 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 2.216E-3 2.901E-2
2.081E-1
1.000E0
 2 266
49 hsa-miR-216a-5p:TargetScan hsa-miR-216a-5p TargetScan 2.233E-3 2.901E-2
2.081E-1
1.000E0
 2 267
50 hsa-miR-3202:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.282E-3 2.901E-2
2.081E-1
1.000E0
 2 270
Show 45 more annotations

17: Drug [Display Chart] 19 input genes in category / 7679 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000019390 AC1L2E0P Stitch 9.146E-21 7.023E-17 6.689E-16 7.023E-17 13 307
2 DB00210 Adapalene Drug Bank 1.377E-19 2.643E-16 2.517E-15 1.057E-15 6 6
3 DB00926 Etretinate Drug Bank 1.377E-19 2.643E-16 2.517E-15 1.057E-15 6 6
4 DB00523 Alitretinoin Drug Bank 1.377E-19 2.643E-16 2.517E-15 1.057E-15 6 6
5 CID000002418 AC1L1DMQ Stitch 2.681E-19 4.118E-16 3.921E-15 2.059E-15 7 14
6 DB00459 Acitretin Drug Bank 9.632E-19 1.215E-15 1.157E-14 7.396E-15 6 7
7 ctd:C103303 alitretinoin CTD 1.108E-18 1.215E-15 1.157E-14 8.508E-15 12 303
8 ctd:C104181 HX 600 CTD 3.851E-18 3.286E-15 3.129E-14 2.957E-14 6 8
9 CID000135754 TTNN Stitch 3.851E-18 3.286E-15 3.129E-14 2.957E-14 6 8
10 CID000446871 AC1L9K70 Stitch 5.421E-18 4.163E-15 3.964E-14 4.163E-14 11 228
11 ctd:D001629 Bezafibrate CTD 6.583E-18 4.596E-15 4.377E-14 5.055E-14 11 232
12 CID000005098 AC1L1JLU Stitch 5.251E-17 3.360E-14 3.200E-13 4.032E-13 9 104
13 ctd:C525131 UVI 3003 CTD 6.344E-17 3.748E-14 3.569E-13 4.872E-13 6 11
14 CID000177238 AGN 193109 Stitch 2.038E-16 1.118E-13 1.065E-12 1.565E-12 7 31
15 CID000216241 Cd2665 Stitch 2.354E-16 1.205E-13 1.148E-12 1.808E-12 6 13
16 CID000130105 CV-1 Stitch 3.453E-16 1.657E-13 1.578E-12 2.652E-12 10 213
17 CID005312120 Ro 41-5253 Stitch 7.958E-16 3.595E-13 3.423E-12 6.111E-12 7 37
18 CID000005602 AC1L1KPQ Stitch 9.371E-16 3.998E-13 3.807E-12 7.196E-12 8 78
19 CID000447912 T0901317 Stitch 1.284E-15 5.189E-13 4.942E-12 9.859E-12 8 81
20 CID000003249 vitamin D2 Stitch 1.366E-15 5.245E-13 4.995E-12 1.049E-11 10 244
21 CID000128016 HX600 Stitch 2.541E-15 9.290E-13 8.847E-12 1.951E-11 6 18
22 CID000005382 TCPOBOP Stitch 4.823E-15 1.683E-12 1.603E-11 3.703E-11 8 95
23 CID000060164 adapalene Stitch 1.019E-14 3.403E-12 3.240E-11 7.826E-11 6 22
24 CID000122342 AC1L3UEY Stitch 2.015E-14 6.446E-12 6.139E-11 1.547E-10 8 113
25 CID000008417 scoparone Stitch 2.415E-14 7.419E-12 7.066E-11 1.855E-10 6 25
26 CID000130325 AC1L2X6Z Stitch 4.033E-14 1.191E-11 1.134E-10 3.097E-10 6 27
27 ctd:C422175 HX 630 CTD 5.644E-14 1.605E-11 1.529E-10 4.334E-10 5 10
28 ctd:D002784 Cholesterol CTD 9.004E-14 2.469E-11 2.352E-10 6.914E-10 9 234
29 CID000119342 CD367 Stitch 1.505E-13 3.984E-11 3.795E-10 1.155E-9 6 33
30 CID000001404 AC1L1BEH Stitch 2.004E-13 5.129E-11 4.885E-10 1.539E-9 7 78
31 CID000000303 sodium cholate Stitch 2.372E-13 5.877E-11 5.597E-10 1.822E-9 10 408
32 CID000147525 tazarotenic acid Stitch 2.878E-13 6.907E-11 6.577E-10 2.210E-9 5 13
33 DB00799 Tazarotene Drug Bank 3.419E-13 7.738E-11 7.369E-10 2.625E-9 4 4
34 CID000094144 5 alpha-androstane Stitch 3.426E-13 7.738E-11 7.369E-10 2.631E-9 7 84
35 CID000005381 tazarotene Stitch 5.197E-13 1.140E-10 1.086E-9 3.991E-9 6 40
36 CID006438384 vitamin D3 analog Stitch 6.085E-13 1.298E-10 1.236E-9 4.673E-9 6 41
37 CID000003312 Etretinate-d3 Stitch 1.100E-12 2.283E-10 2.174E-9 8.448E-9 6 45
38 ctd:C007379 diethyl phthalate CTD 1.655E-12 3.344E-10 3.185E-9 1.271E-8 6 48
39 CID000447276 3,4-didehydroretinoic acid Stitch 1.911E-12 3.669E-10 3.494E-9 1.468E-8 5 18
40 CID000166036 androst-2-en-3-ol Stitch 1.911E-12 3.669E-10 3.494E-9 1.468E-8 5 18
41 CID006439929 E-guggulsterone Stitch 2.086E-12 3.907E-10 3.721E-9 1.602E-8 7 108
42 CID000082146 bexarotene Stitch 2.537E-12 4.639E-10 4.418E-9 1.948E-8 7 111
43 CID005326972 DB04680 Stitch 5.389E-12 9.624E-10 9.165E-9 4.138E-8 8 225
44 ctd:D008055 Lipids CTD 6.044E-12 1.055E-9 1.005E-8 4.641E-8 6 59
45 CID006436116 Ro 15-0778 Stitch 7.486E-12 1.278E-9 1.217E-8 5.749E-8 5 23
46 CID006441236 AGN 190121 Stitch 1.195E-11 1.952E-9 1.859E-8 9.174E-8 4 7
47 CID006366726 AGN 191659 Stitch 1.195E-11 1.952E-9 1.859E-8 9.174E-8 4 7
48 CID000003327 NSC60597 Stitch 1.324E-11 2.118E-9 2.017E-8 1.017E-7 7 140
49 CID000000861 D-triiodothyronine Stitch 1.367E-11 2.119E-9 2.018E-8 1.050E-7 9 409
50 ctd:D017313 Fenretinide CTD 1.380E-11 2.119E-9 2.018E-8 1.060E-7 8 253
Show 45 more annotations

18: Disease [Display Chart] 19 input genes in category / 858 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0008370 Cholestasis DisGeNET Curated 1.745E-9 1.497E-6 1.098E-5 1.497E-6 7 200
2 C0149940 Sciatic Neuropathy DisGeNET Curated 5.462E-9 2.343E-6 1.718E-5 4.686E-6 3 4
3 C0025007 Measles DisGeNET Curated 1.006E-8 2.876E-6 2.109E-5 8.629E-6 6 142
4 C0154251 Lipid Metabolism Disorders DisGeNET Curated 2.714E-8 5.822E-6 4.269E-5 2.329E-5 4 28
5 C0242339 Dyslipidemias DisGeNET Curated 9.821E-8 1.685E-5 1.236E-4 8.427E-5 6 208
6 C4277682 Chemical and Drug Induced Liver Injury DisGeNET Curated 3.661E-6 5.235E-4 3.839E-3 3.141E-3 5 212
7 C0860204 Cholestatic liver disease DisGeNET Curated 4.898E-6 6.003E-4 4.402E-3 4.202E-3 3 29
8 C0410445 Osteomalacia secondary to drug DisGeNET BeFree 7.804E-6 8.369E-4 6.137E-3 6.696E-3 2 4
9 C1859592 ATRICHIA WITH PAPULAR LESIONS DisGeNET Curated 1.416E-5 1.308E-3 9.588E-3 1.215E-2 3 41
10 C0268318 Cholestasis of pregnancy DisGeNET Curated 1.524E-5 1.308E-3 9.588E-3 1.308E-2 3 42
11 C2887821 Left sided colitis DisGeNET BeFree 3.632E-5 2.833E-3 2.077E-2 3.116E-2 2 8
12 C0015695 Fatty Liver DisGeNET Curated 6.123E-5 4.378E-3 3.210E-2
5.253E-2
 5 380
13 C0559031 Functional Gastrointestinal Disorders DisGeNET BeFree 8.536E-5 5.634E-3 4.131E-2
7.324E-2
 2 12
14 C0349204 Nonorganic psychosis DisGeNET Curated 1.111E-4 6.564E-3 4.813E-2
9.532E-2
 4 221
15 C0239946 Fibrosis, Liver DisGeNET Curated 1.148E-4 6.564E-3 4.813E-2
9.847E-2
 5 434
16 C1837218 Cleft palate, isolated DisGeNET BeFree 1.822E-4 9.773E-3
7.166E-2
1.564E-1
 3 96
17 C2711227 Steatohepatitis DisGeNET Curated 1.969E-4 9.938E-3
7.287E-2
1.689E-1
 5 487
18 C1519689 Tumor Promotion DisGeNET BeFree 2.443E-4 1.114E-2
8.168E-2
2.096E-1
 3 106
19 C0008312 Primary biliary cirrhosis DisGeNET Curated 2.467E-4 1.114E-2
8.168E-2
2.117E-1
 4 272
20 C1535950 Gastrointestinal inflammation DisGeNET Curated 2.699E-4 1.158E-2
8.490E-2
2.316E-1
 2 21
21 C0002893 Refractory anemias DisGeNET Curated 3.108E-4 1.244E-2
9.125E-2
2.667E-1
 4 289
22 C0279628 Adenocarcinoma Of Esophagus DisGeNET Curated 3.191E-4 1.244E-2
9.125E-2
2.738E-1
 4 291
23 C0033975 Psychotic Disorders DisGeNET Curated 4.107E-4 1.428E-2
1.047E-1
3.524E-1
 4 311
24 C0022353 Neonatal Jaundice DisGeNET Curated 4.162E-4 1.428E-2
1.047E-1
3.571E-1
 2 26
25 C0566602 Primary sclerosing cholangitis DisGeNET Curated 4.252E-4 1.428E-2
1.047E-1
3.648E-1
 3 128
26 C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 4.415E-4 1.428E-2
1.047E-1
3.788E-1
 4 317
27 C0037928 Spinal Cord Diseases DisGeNET Curated 4.492E-4 1.428E-2
1.047E-1
3.854E-1
 2 27
28 C0078911 AIDS-Associated Nephropathy DisGeNET BeFree 4.834E-4 1.481E-2
1.086E-1
4.148E-1
 2 28
29 C0005956 Bone Marrow Diseases DisGeNET Curated 7.573E-4 1.524E-2
1.118E-1
6.497E-1
 2 35
30 C1847835 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) DisGeNET Curated 7.714E-4 1.524E-2
1.118E-1
6.618E-1
 3 157
31 C0740457 Malignant neoplasm of kidney DisGeNET BeFree 8.471E-4 1.524E-2
1.118E-1
7.268E-1
 4 377
32 C0020676 Hypothyroidism DisGeNET Curated 9.549E-4 1.524E-2
1.118E-1
8.193E-1
 3 169
33 C0278488 Carcinoma breast stage IV DisGeNET BeFree 9.612E-4 1.524E-2
1.118E-1
8.247E-1
 4 390
34 C0037274 Dermatologic disorders DisGeNET Curated 9.890E-4 1.524E-2
1.118E-1
8.486E-1
 4 393
35 C0020626 Hypoparathyroidism DisGeNET Curated 9.893E-4 1.524E-2
1.118E-1
8.488E-1
 2 40
36 C0042900 Vitiligo DisGeNET Curated 1.005E-3 1.524E-2
1.118E-1
8.621E-1
 3 172
37 C0025517 Metabolic Diseases DisGeNET Curated 1.008E-3 1.524E-2
1.118E-1
8.648E-1
 4 395
38 C0751956 Acute Cerebrovascular Accidents DisGeNET BeFree 1.039E-3 1.524E-2
1.118E-1
8.917E-1
 2 41
39 C0206698 Cholangiocarcinoma DisGeNET Curated 1.106E-3 1.524E-2
1.118E-1
9.490E-1
 4 405
40 C0006287 Bronchopulmonary Dysplasia DisGeNET Curated 1.164E-3 1.524E-2
1.118E-1
9.988E-1
 3 181
41 C0011615 Dermatitis, Atopic DisGeNET Curated 1.168E-3 1.524E-2
1.118E-1
1.000E0
 4 411
42 C0264487 Chronic nonspecific lung disease DisGeNET BeFree 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
43 C2931037 Pancreatic cancer, adult DisGeNET Curated 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
44 OMIN:608584 ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2 OMIM 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
45 C2983423 Stage III Hepatocellular Carcinoma DisGeNET BeFree 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
46 cv:C1837811 ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2 Clinical Variations 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
47 C0262977 Achromia of skin DisGeNET BeFree 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
48 C1336456 Stage I Hepatocellular Carcinoma DisGeNET BeFree 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
49 C3826804 Abdominal pain in children DisGeNET BeFree 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
50 C0042237 Malignant Vaginal Neoplasm DisGeNET BeFree 1.172E-3 1.524E-2
1.118E-1
1.000E0
 1 1
Show 45 more annotations