Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc60_12, positive side

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Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 12 input genes in category / 47 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005262 calcium channel activity 3.218E-24 1.513E-22 6.713E-22 1.513E-22 11 114
2 GO:0015085 calcium ion transmembrane transporter activity 1.730E-23 4.065E-22 1.804E-21 8.129E-22 11 132
3 GO:0005261 cation channel activity 3.049E-22 4.409E-21 1.957E-20 1.433E-20 12 306
4 GO:0072509 divalent inorganic cation transmembrane transporter activity 3.752E-22 4.409E-21 1.957E-20 1.763E-20 11 173
5 GO:0005216 ion channel activity 1.624E-20 1.347E-19 5.977E-19 7.631E-19 12 424
6 GO:0046873 metal ion transmembrane transporter activity 1.719E-20 1.347E-19 5.977E-19 8.080E-19 12 426
7 GO:0022838 substrate-specific channel activity 2.410E-20 1.618E-19 7.181E-19 1.133E-18 12 438
8 GO:0015267 channel activity 5.675E-20 3.041E-19 1.350E-18 2.667E-18 12 470
9 GO:0022803 passive transmembrane transporter activity 5.824E-20 3.041E-19 1.350E-18 2.737E-18 12 471
10 GO:0005516 calmodulin binding 4.835E-6 2.273E-5 1.009E-4 2.273E-4 4 190
11 GO:0022836 gated channel activity 4.300E-5 1.837E-4 8.153E-4 2.021E-3 4 331
12 GO:0005227 calcium activated cation channel activity 1.633E-4 6.394E-4 2.838E-3 7.673E-3 2 30
13 GO:0005272 sodium channel activity 2.493E-4 9.014E-4 4.000E-3 1.172E-2 2 37
14 GO:0022839 ion gated channel activity 3.696E-4 1.241E-3 5.506E-3 1.737E-2 2 45
15 GO:0015275 stretch-activated, cation-selective, calcium channel activity 6.431E-4 2.015E-3 8.942E-3 3.022E-2 1 1
16 GO:0005034 osmosensor activity 1.286E-3 3.777E-3 1.676E-2
6.043E-2
 1 2
17 GO:0097603 temperature-gated ion channel activity 1.928E-3 5.330E-3 2.366E-2
9.062E-2
 1 3
18 GO:0008381 mechanosensitive ion channel activity 2.570E-3 6.710E-3 2.978E-2
1.208E-1
 1 4
19 GO:0047631 ADP-ribose diphosphatase activity 3.211E-3 7.796E-3 3.460E-2
1.509E-1
 1 5
20 GO:0015081 sodium ion transmembrane transporter activity 3.317E-3 7.796E-3 3.460E-2
1.559E-1
 2 136
21 GO:0005384 manganese ion transmembrane transporter activity 4.493E-3 1.006E-2 4.463E-2
2.112E-1
 1 7
22 GO:0099604 ligand-gated calcium channel activity 1.024E-2 2.093E-2
9.290E-2
4.814E-1
 1 16
23 GO:0015278 calcium-release channel activity 1.024E-2 2.093E-2
9.290E-2
4.814E-1
 1 16
24 GO:0017081 chloride channel regulator activity 1.088E-2 2.131E-2
9.456E-2
5.114E-1
 1 17
25 GO:0043014 alpha-tubulin binding 1.850E-2 3.458E-2
1.534E-1
8.693E-1
 1 29
26 GO:0005217 intracellular ligand-gated ion channel activity 1.913E-2 3.458E-2
1.534E-1
8.990E-1
 1 30
27 GO:0042169 SH2 domain binding 2.165E-2 3.769E-2
1.673E-1
1.000E0
 1 34
28 GO:0015077 monovalent inorganic cation transmembrane transporter activity 2.327E-2 3.906E-2
1.733E-1
1.000E0
 2 375
29 GO:0048487 beta-tubulin binding 2.606E-2 4.181E-2
1.855E-1
1.000E0
 1 41
30 GO:0046915 transition metal ion transmembrane transporter activity 2.668E-2 4.181E-2
1.855E-1
1.000E0
 1 42
31 GO:0003779 actin binding 2.773E-2 4.204E-2
1.866E-1
1.000E0
 2 412
Show 26 more annotations

2: GO: Biological Process [Display Chart] 12 input genes in category / 395 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070588 calcium ion transmembrane transport 7.068E-23 2.792E-20 1.831E-19 2.792E-20 12 271
2 GO:0006816 calcium ion transport 9.527E-21 1.882E-18 1.234E-17 3.763E-18 12 405
3 GO:0070838 divalent metal ion transport 3.922E-20 4.195E-18 2.751E-17 1.549E-17 12 455
4 GO:0072511 divalent inorganic cation transport 4.248E-20 4.195E-18 2.751E-17 1.678E-17 12 458
5 GO:0072507 divalent inorganic cation homeostasis 5.720E-11 4.518E-9 2.963E-8 2.259E-8 8 458
6 GO:0070509 calcium ion import 6.386E-10 4.204E-8 2.757E-7 2.523E-7 6 179
7 GO:0055074 calcium ion homeostasis 2.203E-9 1.243E-7 8.151E-7 8.701E-7 7 425
8 GO:0072503 cellular divalent inorganic cation homeostasis 2.589E-9 1.278E-7 8.382E-7 1.023E-6 7 435
9 GO:0009266 response to temperature stimulus 3.370E-9 1.479E-7 9.699E-7 1.331E-6 6 236
10 GO:0051262 protein tetramerization 2.565E-8 1.013E-6 6.643E-6 1.013E-5 5 152
11 GO:0006874 cellular calcium ion homeostasis 9.201E-8 3.304E-6 2.167E-5 3.635E-5 6 411
12 GO:0016048 detection of temperature stimulus 2.316E-7 7.623E-6 4.999E-5 9.148E-5 3 20
13 GO:0050951 sensory perception of temperature stimulus 3.126E-7 9.499E-6 6.229E-5 1.235E-4 3 22
14 GO:0007204 positive regulation of cytosolic calcium ion concentration 5.386E-7 1.520E-5 9.965E-5 2.128E-4 5 280
15 GO:0051480 regulation of cytosolic calcium ion concentration 8.353E-7 2.200E-5 1.442E-4 3.300E-4 5 306
16 GO:0060402 calcium ion transport into cytosol 1.853E-6 4.542E-5 2.978E-4 7.321E-4 4 149
17 GO:0060401 cytosolic calcium ion transport 1.955E-6 4.542E-5 2.978E-4 7.721E-4 4 151
18 GO:0050955 thermoception 2.282E-6 5.008E-5 3.284E-4 9.014E-4 2 4
19 GO:0009408 response to heat 3.208E-6 6.669E-5 4.373E-4 1.267E-3 4 171
20 GO:0002024 diet induced thermogenesis 2.087E-5 4.121E-4 2.702E-3 8.242E-3 2 11
21 GO:1990845 adaptive thermogenesis 2.503E-5 4.708E-4 3.087E-3 9.887E-3 2 12
22 GO:0002021 response to dietary excess 1.042E-4 1.871E-3 1.227E-2 4.117E-2 2 24
23 GO:0009581 detection of external stimulus 1.200E-4 2.061E-3 1.351E-2 4.740E-2 3 156
24 GO:0009582 detection of abiotic stimulus 1.270E-4 2.090E-3 1.370E-2
5.015E-2
 3 159
25 GO:0071642 positive regulation of macrophage inflammatory protein 1 alpha production 6.444E-4 8.484E-3
5.563E-2
2.545E-1
 1 1
26 GO:1903444 negative regulation of brown fat cell differentiation 6.444E-4 8.484E-3
5.563E-2
2.545E-1
 1 1
27 GO:0050960 detection of temperature stimulus involved in thermoception 6.444E-4 8.484E-3
5.563E-2
2.545E-1
 1 1
28 GO:1903759 signal transduction involved in regulation of aerobic respiration 6.444E-4 8.484E-3
5.563E-2
2.545E-1
 1 1
29 GO:0060232 delamination 6.444E-4 8.484E-3
5.563E-2
2.545E-1
 1 1
30 GO:0097497 blood vessel endothelial cell delamination 6.444E-4 8.484E-3
5.563E-2
2.545E-1
 1 1
31 GO:0090280 positive regulation of calcium ion import 7.273E-4 9.145E-3
5.996E-2
2.873E-1
 2 63
32 GO:0002790 peptide secretion 7.408E-4 9.145E-3
5.996E-2
2.926E-1
 3 290
33 GO:0090212 negative regulation of establishment of blood-brain barrier 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
34 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
35 GO:0007231 osmosensory signaling pathway 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
36 GO:0071477 cellular hypotonic salinity response 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
37 GO:0098703 calcium ion import across plasma membrane 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
38 GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
39 GO:0042539 hypotonic salinity response 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
40 GO:0016340 calcium-dependent cell-matrix adhesion 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
41 GO:0030103 vasopressin secretion 1.288E-3 1.241E-2
8.139E-2
5.089E-1
 1 2
42 GO:0046879 hormone secretion 1.351E-3 1.241E-2
8.140E-2
5.338E-1
 3 357
43 GO:0015833 peptide transport 1.351E-3 1.241E-2
8.140E-2
5.338E-1
 3 357
44 GO:0009914 hormone transport 1.498E-3 1.345E-2
8.817E-2
5.916E-1
 3 370
45 GO:0042886 amide transport 1.666E-3 1.463E-2
9.591E-2
6.582E-1
 3 384
46 GO:0050968 detection of chemical stimulus involved in sensory perception of pain 1.932E-3 1.496E-2
9.812E-2
7.631E-1
 1 3
47 GO:0071608 macrophage inflammatory protein-1 alpha production 1.932E-3 1.496E-2
9.812E-2
7.631E-1
 1 3
48 GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production 1.932E-3 1.496E-2
9.812E-2
7.631E-1
 1 3
49 GO:0072566 chemokine (C-X-C motif) ligand 1 production 1.932E-3 1.496E-2
9.812E-2
7.631E-1
 1 3
50 GO:0060454 positive regulation of gastric acid secretion 1.932E-3 1.496E-2
9.812E-2
7.631E-1
 1 3
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 12 input genes in category / 51 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031252 cell leading edge 7.426E-5 3.787E-3 1.711E-2 3.787E-3 4 389
2 GO:0030427 site of polarized growth 1.915E-4 4.884E-3 2.207E-2 9.768E-3 3 187
3 GO:0035841 new growing cell tip 1.259E-3 2.140E-2
9.670E-2
6.420E-2
 1 2
4 GO:0035838 growing cell tip 1.888E-3 2.407E-2
1.088E-1
9.627E-2
 1 3
5 GO:0031256 leading edge membrane 3.855E-3 2.911E-2
1.316E-1
1.966E-1
 2 150
6 GO:0001726 ruffle 4.865E-3 2.911E-2
1.316E-1
2.481E-1
 2 169
7 GO:0032584 growth cone membrane 5.026E-3 2.911E-2
1.316E-1
2.563E-1
 1 8
8 GO:0030426 growth cone 5.619E-3 2.911E-2
1.316E-1
2.866E-1
 2 182
9 GO:0051286 cell tip 5.653E-3 2.911E-2
1.316E-1
2.883E-1
 1 9
10 GO:0030027 lamellipodium 5.862E-3 2.911E-2
1.316E-1
2.989E-1
 2 186
11 GO:0032591 dendritic spine membrane 6.279E-3 2.911E-2
1.316E-1
3.202E-1
 1 10
12 GO:0043196 varicosity 9.405E-3 3.997E-2
1.806E-1
4.797E-1
 1 15
Show 7 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 393 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007230 Decreased distal sensory nerve action potential 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
2 HP:0003332 Absent primary metaphyseal spongiosa 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
3 HP:0009060 Scapular muscle atrophy 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
4 HP:0005042 Irregular, rachitic-like metaphyses 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
5 HP:0003562 Abnormal metaphyseal vascular invasion 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
6 HP:0008922 Childhood-onset short-trunk short stature 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
7 HP:0002822 Hyperplasia of the femoral trochanters 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
8 HP:0002766 Relatively short spine 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
9 HP:0005793 Shortening of all distal phalanges of the toes 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
10 HP:0002810 Dumbbell-shaped metaphyses 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
11 HP:0008964 Nonprogressive muscular atrophy 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
12 HP:0005872 Brachytelomesophalangy 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
13 HP:0002831 Long coccyx 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
14 HP:0006239 Shortening of all middle phalanges of the toes 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
15 HP:0006069 Severe carpal ossification delay 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
16 HP:0002826 Halberd-shaped pelvis 8.498E-4 2.087E-2
1.368E-1
3.340E-1
 1 1
17 HP:0004268 Osteoarthritis of the small joints of the hand 1.699E-3 3.514E-2
2.303E-1
6.677E-1
 1 2
18 HP:0011727 Peroneal muscle weakness 1.699E-3 3.514E-2
2.303E-1
6.677E-1
 1 2
19 HP:0003500 Short-trunked dwarfism 1.699E-3 3.514E-2
2.303E-1
6.677E-1
 1 2
20 HP:0003697 Scapuloperoneal amyotrophy 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
21 HP:0009049 Peroneal muscle atrophy 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
22 HP:0004878 Intercostal muscle weakness 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
23 HP:0001465 Amyotrophy involving the shoulder musculature 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
24 HP:0008833 Irregular acetabular roof 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
25 HP:0008955 Progressive distal muscular atrophy 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
26 HP:0005089 Abnormal metaphyseal trabeculation 2.548E-3 3.813E-2
2.498E-1
1.000E0
 1 3
27 HP:0003911 Flared humeral metaphysis 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
28 HP:0001857 Short distal phalanx of toe 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
29 HP:0002825 Caudal appendage 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
30 HP:0030179 Abnormal peripheral action potential amplitude 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
31 HP:0008956 Proximal lower limb amyotrophy 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
32 HP:0011041 Aplasia/Hypoplasia of the cervical spine 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
33 HP:0007078 Decreased amplitude of sensory action potentials 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
34 HP:0100818 Long thorax 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
35 HP:0008434 Hypoplastic cervical vertebrae 3.396E-3 3.813E-2
2.498E-1
1.000E0
 1 4
36 HP:0001441 Abnormality of the musculature of the thigh 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
37 HP:0003411 Proximal femoral metaphyseal irregularity 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
38 HP:0002879 Anisospondyly 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
39 HP:0009063 Progressive distal muscle weakness 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
40 HP:0005035 Shortening of all phalanges of the toes 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
41 HP:0003849 Flared upper limb metaphysis 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
42 HP:0003856 Upper limb metaphyseal widening 4.244E-3 3.971E-2
2.602E-1
1.000E0
 1 5
43 HP:0003634 Amyoplasia 5.091E-3 4.257E-2
2.789E-1
1.000E0
 1 6
44 HP:0030307 Flared lower limb metaphysis 5.091E-3 4.257E-2
2.789E-1
1.000E0
 1 6
45 HP:0002834 Flared femoral metaphysis 5.091E-3 4.257E-2
2.789E-1
1.000E0
 1 6
46 HP:0003795 Short middle phalanx of toe 5.091E-3 4.257E-2
2.789E-1
1.000E0
 1 6
47 HP:0030291 Lower-limb metaphyseal irregularity 5.091E-3 4.257E-2
2.789E-1
1.000E0
 1 6
48 HP:0003907 Abnormality of the humeral metaphyses 5.937E-3 4.575E-2
2.998E-1
1.000E0
 1 7
49 HP:0008392 Subungual hyperkeratosis 5.937E-3 4.575E-2
2.998E-1
1.000E0
 1 7
50 HP:0008519 Abnormality of the coccyx 5.937E-3 4.575E-2
2.998E-1
1.000E0
 1 7
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 12 input genes in category / 359 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003663 abnormal thermosensation 6.638E-8 1.353E-5 8.740E-5 2.383E-5 3 8
2 MP:0001973 increased thermal nociceptive threshold 7.648E-8 1.353E-5 8.740E-5 2.746E-5 5 106
3 MP:0002736 abnormal nociception after inflammation 1.130E-7 1.353E-5 8.740E-5 4.058E-5 4 42
4 MP:0002733 abnormal thermal nociception 5.820E-7 4.586E-5 2.963E-4 2.089E-4 5 159
5 MP:0003043 hypoalgesia 6.387E-7 4.586E-5 2.963E-4 2.293E-4 5 162
6 MP:0008531 increased chemical nociceptive threshold 4.744E-6 2.838E-4 1.834E-3 1.703E-3 3 30
7 MP:0001970 abnormal pain threshold 5.542E-6 2.842E-4 1.836E-3 1.989E-3 5 251
8 MP:0001968 abnormal touch/ nociception 1.433E-5 6.433E-4 4.157E-3 5.146E-3 5 305
9 MP:0002735 abnormal chemical nociception 1.874E-5 7.474E-4 4.830E-3 6.726E-3 3 47
10 MP:0001986 abnormal taste sensitivity 1.282E-4 4.602E-3 2.974E-2 4.602E-2 2 15
11 MP:0008997 increased blood osmolality 1.658E-4 5.412E-3 3.497E-2
5.953E-2
 2 17
12 MP:0001985 abnormal gustatory system physiology 2.082E-4 6.230E-3 4.026E-2
7.476E-2
 2 19
13 MP:0008996 abnormal blood osmolality 2.312E-4 6.385E-3 4.126E-2
8.301E-2
 2 20
14 MP:0011947 abnormal fluid intake 3.741E-4 9.430E-3
6.093E-2
1.343E-1
 3 128
15 MP:0002734 abnormal mechanical nociception 3.940E-4 9.430E-3
6.093E-2
1.414E-1
 2 26
16 MP:0011942 decreased fluid intake 5.990E-4 1.307E-2
8.447E-2
2.150E-1
 2 32
17 MP:0001422 abnormal drinking behavior 6.190E-4 1.307E-2
8.447E-2
2.222E-1
 3 152
18 MP:0001756 abnormal urination 7.725E-4 1.541E-2
9.956E-2
2.773E-1
 3 164
19 MP:0003484 abnormal channel response 8.457E-4 1.598E-2
1.033E-1
3.036E-1
 2 38
20 MP:0012025 abnormal comma shaped body morphology 1.159E-3 1.809E-2
1.169E-1
4.160E-1
 1 1
21 MP:0004212 abnormal salty taste sensitivity 1.159E-3 1.809E-2
1.169E-1
4.160E-1
 1 1
22 MP:0008812 abnormal rostrocaudal coat patterning 1.159E-3 1.809E-2
1.169E-1
4.160E-1
 1 1
23 MP:0004211 abnormal sour taste sensitivity 1.159E-3 1.809E-2
1.169E-1
4.160E-1
 1 1
24 MP:0012367 decreased erythrocyte magnesium level 2.316E-3 3.199E-2
2.067E-1
8.316E-1
 1 2
25 MP:0012026 abnormal S-shaped body morphology 2.316E-3 3.199E-2
2.067E-1
8.316E-1
 1 2
26 MP:0005611 decreased circulating antidiuretic hormone level 2.316E-3 3.199E-2
2.067E-1
8.316E-1
 1 2
27 MP:0010055 abnormal sensory neuron physiology 2.688E-3 3.574E-2
2.309E-1
9.650E-1
 2 68
28 MP:0002412 increased susceptibility to bacterial infection 2.974E-3 3.813E-2
2.464E-1
1.000E0
 3 262
29 MP:0003022 increased coronary flow rate 3.473E-3 4.022E-2
2.599E-1
1.000E0
 1 3
30 MP:0008998 decreased blood osmolality 3.473E-3 4.022E-2
2.599E-1
1.000E0
 1 3
31 MP:0012366 abnormal erythrocyte magnesium level 3.473E-3 4.022E-2
2.599E-1
1.000E0
 1 3
32 MP:0002703 abnormal renal tubule morphology 3.849E-3 4.225E-2
2.730E-1
1.000E0
 3 287
33 MP:0005423 abnormal somatic nervous system physiology 3.883E-3 4.225E-2
2.730E-1
1.000E0
 2 82
34 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality 4.071E-3 4.299E-2
2.778E-1
1.000E0
 2 84
35 MP:0003821 decreased left ventricle diastolic pressure 4.628E-3 4.372E-2
2.825E-1
1.000E0
 1 4
36 MP:0003454 erythroderma 4.628E-3 4.372E-2
2.825E-1
1.000E0
 1 4
37 MP:0003332 liver abscess 4.628E-3 4.372E-2
2.825E-1
1.000E0
 1 4
38 MP:0012024 abnormal nephron morphogenesis 4.628E-3 4.372E-2
2.825E-1
1.000E0
 1 4
39 MP:0004484 altered response of heart to induced stress 5.178E-3 4.766E-2
3.080E-1
1.000E0
 2 95
40 MP:0003823 increased left ventricle developed pressure 5.782E-3 4.928E-2
3.184E-1
1.000E0
 1 5
41 MP:0010111 abnormal renal calcium reabsorbtion 5.782E-3 4.928E-2
3.184E-1
1.000E0
 1 5
42 MP:0004210 abnormal bitter taste sensitivity 5.782E-3 4.928E-2
3.184E-1
1.000E0
 1 5
43 MP:0011941 increased fluid intake 5.946E-3 4.928E-2
3.184E-1
1.000E0
 2 102
44 MP:0020186 altered susceptibility to bacterial infection 6.039E-3 4.928E-2
3.184E-1
1.000E0
 3 337
Show 39 more annotations

6: Domain [Display Chart] 12 input genes in category / 38 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR005821 Ion trans dom InterPro 1.420E-27 2.697E-26 1.140E-25 5.395E-26 12 114
2 PF00520 Ion trans Pfam 1.420E-27 2.697E-26 1.140E-25 5.395E-26 12 114
3 IPR004729 TRP channel InterPro 1.900E-14 2.406E-13 1.017E-12 7.219E-13 5 11
4 IPR008347 TRPV1-4 channel InterPro 9.646E-14 9.164E-13 3.874E-12 3.665E-12 4 4
5 PF16519 TRPM tetra Pfam 8.028E-10 5.084E-9 2.150E-8 3.050E-8 3 4
6 IPR032415 TRPM tetra InterPro 8.028E-10 5.084E-9 2.150E-8 3.050E-8 3 4
7 PF00023 Ank Pfam 2.860E-9 1.553E-8 6.564E-8 1.087E-7 6 231
8 1.25.40.20 - Gene3D 4.379E-9 1.717E-8 7.258E-8 1.664E-7 6 248
9 SM00248 ANK SMART 5.053E-9 1.717E-8 7.258E-8 1.920E-7 6 254
10 PS50088 ANK REPEAT PROSITE 5.296E-9 1.717E-8 7.258E-8 2.012E-7 6 256
11 PS50297 ANK REP REGION PROSITE 5.421E-9 1.717E-8 7.258E-8 2.060E-7 6 257
12 IPR020683 Ankyrin rpt-contain dom InterPro 5.421E-9 1.717E-8 7.258E-8 2.060E-7 6 257
13 IPR002110 Ankyrin rpt InterPro 6.513E-9 1.904E-8 8.049E-8 2.475E-7 6 265
14 PF12796 Ank 2 Pfam 1.409E-7 3.825E-7 1.617E-6 5.356E-6 5 215
15 IPR008344 TRPV5/TRPV6 InterPro 3.761E-7 8.932E-7 3.776E-6 1.429E-5 2 2
16 IPR008348 TRPV4 channel InterPro 3.761E-7 8.932E-7 3.776E-6 1.429E-5 2 2
17 IPR024866 TRPV3 channel InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
18 IPR029594 TRPM2 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
19 IPR029603 TRPM8 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
20 IPR008346 TRPV5 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
21 IPR029577 TRPM5 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
22 IPR024865 TRPV2 channel InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
23 IPR008345 TRPV6 channel InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
24 IPR029588 TRPM1 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
25 IPR029601 TRPM7 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
26 IPR029583 TRPM3 InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
27 IPR024863 TRPV1 channel InterPro 6.405E-4 9.015E-4 3.811E-3 2.434E-2 1 1
28 PF02816 Alpha kinase Pfam 4.476E-3 5.315E-3 2.247E-2
1.701E-1
 1 7
29 PS51158 ALPHA KINASE PROSITE 4.476E-3 5.315E-3 2.247E-2
1.701E-1
 1 7
30 IPR002153 TRPC channel InterPro 4.476E-3 5.315E-3 2.247E-2
1.701E-1
 1 7
31 IPR004166 MHCK EF2 kinase InterPro 4.476E-3 5.315E-3 2.247E-2
1.701E-1
 1 7
32 SM00811 Alpha kinase SMART 4.476E-3 5.315E-3 2.247E-2
1.701E-1
 1 7
33 PS00893 NUDIX BOX PROSITE 1.527E-2 1.758E-2
7.434E-2
5.802E-1
 1 24
34 PS51462 NUDIX PROSITE 1.653E-2 1.848E-2
7.812E-2
6.282E-1
 1 26
35 3.90.79.10 - Gene3D 1.779E-2 1.878E-2
7.941E-2
6.761E-1
 1 28
36 IPR015797 NUDIX hydrolase dom-like InterPro 1.779E-2 1.878E-2
7.941E-2
6.761E-1
 1 28
37 IPR000086 NUDIX hydrolase dom InterPro 1.842E-2 1.892E-2
8.000E-2
7.001E-1
 1 29
38 IPR008996 Cytokine IL1-like InterPro 2.282E-2 2.282E-2
9.649E-2
8.673E-1
 1 36
Show 33 more annotations

7: Pathway [Display Chart] 12 input genes in category / 15 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269954 TRP channels BioSystems: REACTOME 1.806E-34 2.708E-33 8.987E-33 2.708E-33 12 25
2 1269953 Stimuli-sensing channels BioSystems: REACTOME 6.002E-26 4.502E-25 1.494E-24 9.003E-25 12 104
3 1269950 Ion channel transport BioSystems: REACTOME 3.650E-22 1.825E-21 6.056E-21 5.475E-21 12 209
4 948277 Inflammatory mediator regulation of TRP channels BioSystems: KEGG 1.963E-8 7.360E-8 2.442E-7 2.944E-7 5 97
5 122191 NOD-like receptor signaling pathway BioSystems: KEGG 5.026E-4 1.508E-3 5.003E-3 7.539E-3 3 170
6 212237 Mineral absorption BioSystems: KEGG 1.058E-3 2.644E-3 8.775E-3 1.587E-2 2 51
Show 1 more annotation

8: Pubmed [Display Chart] 12 input genes in category / 2310 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16382100 International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pubmed 2.590E-40 5.556E-37 4.624E-36 5.983E-37 12 25
2 16460286 An introduction to TRP channels. Pubmed 4.810E-40 5.556E-37 4.624E-36 1.111E-36 12 26
3 19834762 A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. Pubmed 1.125E-38 8.659E-36 7.207E-35 2.598E-35 12 32
4 19322198 Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. Pubmed 7.640E-37 4.412E-34 3.672E-33 1.765E-33 12 43
5 19850157 Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Pubmed 1.980E-19 9.146E-17 7.612E-16 4.573E-16 6 12
6 12077606 TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Pubmed 1.170E-18 4.504E-16 3.748E-15 2.702E-15 5 5
7 18701070 Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Pubmed 2.456E-17 8.104E-15 6.745E-14 5.673E-14 5 7
8 18983665 Quantitative Real-Time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects. Pubmed 5.584E-15 9.922E-13 8.258E-12 1.290E-11 4 4
9 17521436 Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. Pubmed 5.584E-15 9.922E-13 8.258E-12 1.290E-11 4 4
10 19839244 Expression of transient receptor potential vanilloid (TRPV) families 1, 2, 3 and 4 in the mouse olfactory epithelium. Pubmed 5.584E-15 9.922E-13 8.258E-12 1.290E-11 4 4
11 25752528 Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channels. Pubmed 5.584E-15 9.922E-13 8.258E-12 1.290E-11 4 4
12 18787888 Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells. Pubmed 5.584E-15 9.922E-13 8.258E-12 1.290E-11 4 4
13 25333484 Dissecting domain-specific evolutionary pressure profiles of transient receptor potential vanilloid subfamily members 1 to 4. Pubmed 5.584E-15 9.922E-13 8.258E-12 1.290E-11 4 4
14 15194687 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. Pubmed 2.792E-14 4.299E-12 3.578E-11 6.449E-11 4 5
15 12765698 Role and regulation of TRP channels in neutrophil granulocytes. Pubmed 2.792E-14 4.299E-12 3.578E-11 6.449E-11 4 5
16 19482060 Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
17 29175331 Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
18 20015940 Functional characterization of transient receptor potential channels in mouse urothelial cells. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
19 28905239 Expression and distribution of three transient receptor potential vanilloid(TRPV) channel proteins in human odontoblast-like cells. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
20 18607942 Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
21 28158279 Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
22 21506114 Thermosensitive transient receptor potential channels in human corneal epithelial cells. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
23 12093812 Molecular determinants of permeation through the cation channel TRPV4. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
24 22327830 Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
25 27291418 A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
26 12016205 A heat-sensitive TRP channel expressed in keratinocytes. Pubmed 2.370E-11 2.105E-9 1.752E-8 5.474E-8 3 3
27 25501034 TRPA1 is essential for the vascular response to environmental cold exposure. Pubmed 9.476E-11 8.108E-9 6.747E-8 2.189E-7 3 4
28 30037926 Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress. Pubmed 1.999E-10 1.649E-8 1.372E-7 4.617E-7 4 32
29 16857711 Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte. Pubmed 2.369E-10 1.887E-8 1.570E-7 5.472E-7 3 5
30 15561438 TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Pubmed 4.736E-10 3.647E-8 3.035E-7 1.094E-6 3 6
31 20357111 TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. Pubmed 1.988E-9 1.482E-7 1.233E-6 4.593E-6 3 9
32 25369838 ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Pubmed 1.607E-8 1.160E-6 9.656E-6 3.713E-5 3 17
33 16446141 Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Pubmed 2.290E-8 1.603E-6 1.334E-5 5.289E-5 3 19
34 24646197 The effects of hydrated C(60) fullerene on gene expression profile of TRPM2 and TRPM7 in hyperhomocysteinemic mice. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
35 19887679 In with the TRP channels: intracellular functions for TRPM1 and TRPM2. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
36 25069877 Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
37 26546534 Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
38 19619644 Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
39 21994383 Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
40 22162417 SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
41 25641129 Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
42 21278253 Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
43 12077127 Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
44 11549322 Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
45 15254097 Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
46 21832173 TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
47 24133266 Amplified cold transduction in native nociceptors by M-channel inhibition. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
48 19482068 Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
49 22354706 The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
50 16115206 Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Pubmed 9.049E-8 1.883E-6 1.567E-5 2.090E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 110 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AKAP5 AKAP5 interactions 3.427E-11 3.769E-9 1.991E-8 3.769E-9 5 44
2 int:TRPV2 TRPV2 interactions 2.105E-6 1.158E-4 6.114E-4 2.315E-4 2 4
3 int:CALB1 CALB1 interactions 1.925E-5 7.057E-4 3.728E-3 2.117E-3 2 11
4 int:TRPV1 TRPV1 interactions 2.728E-5 7.501E-4 3.962E-3 3.000E-3 2 13
5 int:S100A10 S100A10 interactions 4.754E-4 1.046E-2
5.525E-2
5.229E-2
 2 53
6 int:CALM1 CALM1 interactions 1.069E-3 1.708E-2
9.023E-2
1.176E-1
 3 344
7 int:TRPV3 TRPV3 interactions 1.242E-3 1.708E-2
9.023E-2
1.367E-1
 1 2
8 int:TRPM6 TRPM6 interactions 1.242E-3 1.708E-2
9.023E-2
1.367E-1
 1 2
9 int:OS9 OS9 interactions 2.177E-3 2.483E-2
1.312E-1
2.394E-1
 2 114
10 int:SLC50A1 SLC50A1 interactions 2.483E-3 2.483E-2
1.312E-1
2.732E-1
 1 4
11 int:TRPM1 TRPM1 interactions 2.483E-3 2.483E-2
1.312E-1
2.732E-1
 1 4
12 int:TRPM2 TRPM2 interactions 3.103E-3 2.845E-2
1.503E-1
3.414E-1
 1 5
13 int:TRPM3 TRPM3 interactions 4.342E-3 3.412E-2
1.802E-1
4.776E-1
 1 7
14 int:KL KL interactions 4.342E-3 3.412E-2
1.802E-1
4.776E-1
 1 7
15 int:SYT9 SYT9 interactions 4.961E-3 3.638E-2
1.922E-1
5.457E-1
 1 8
16 int:ITCH ITCH interactions 6.096E-3 4.191E-2
2.214E-1
6.705E-1
 2 193
17 int:TRPM4 TRPM4 interactions 6.816E-3 4.410E-2
2.330E-1
7.497E-1
 1 11
18 int:TRPM8 TRPM8 interactions 8.050E-3 4.661E-2
2.462E-1
8.855E-1
 1 13
19 int:PNLDC1 PNLDC1 interactions 8.050E-3 4.661E-2
2.462E-1
8.855E-1
 1 13
20 int:PLCB2 PLCB2 interactions 8.667E-3 4.709E-2
2.488E-1
9.534E-1
 1 14
21 int:KCNJ11 KCNJ11 interactions 1.052E-2 4.709E-2
2.488E-1
1.000E0
 1 17
22 int:TRPV6 TRPV6 interactions 1.052E-2 4.709E-2
2.488E-1
1.000E0
 1 17
23 int:TRPC6 TRPC6 interactions 1.052E-2 4.709E-2
2.488E-1
1.000E0
 1 17
24 int:OSM OSM interactions 1.113E-2 4.709E-2
2.488E-1
1.000E0
 1 18
25 int:RAB11FIP3 RAB11FIP3 interactions 1.113E-2 4.709E-2
2.488E-1
1.000E0
 1 18
26 int:TRPV4 TRPV4 interactions 1.113E-2 4.709E-2
2.488E-1
1.000E0
 1 18
27 int:KRIT1 KRIT1 interactions 1.175E-2 4.785E-2
2.528E-1
1.000E0
 1 19
28 int:TRPM7 TRPM7 interactions 1.359E-2 4.902E-2
2.589E-1
1.000E0
 1 22
29 int:PCNX3 PCNX3 interactions 1.482E-2 4.902E-2
2.589E-1
1.000E0
 1 24
30 int:GCLM GCLM interactions 1.482E-2 4.902E-2
2.589E-1
1.000E0
 1 24
31 int:TRPV5 TRPV5 interactions 1.482E-2 4.902E-2
2.589E-1
1.000E0
 1 24
32 int:TEX28 TEX28 interactions 1.543E-2 4.902E-2
2.589E-1
1.000E0
 1 25
33 int:MYH2 MYH2 interactions 1.543E-2 4.902E-2
2.589E-1
1.000E0
 1 25
34 int:PLCB3 PLCB3 interactions 1.604E-2 4.902E-2
2.589E-1
1.000E0
 1 26
35 int:PLCB1 PLCB1 interactions 1.604E-2 4.902E-2
2.589E-1
1.000E0
 1 26
36 int:PDE9A PDE9A interactions 1.604E-2 4.902E-2
2.589E-1
1.000E0
 1 26
Show 31 more annotations

10: Cytoband [Display Chart] 12 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17p13.2 17p13.2 1.735E-4 1.909E-3 5.764E-3 1.909E-3 2 57
2 9q21.12 9q21.12 3.457E-3 1.394E-2 4.210E-2 3.803E-2 1 10
3 15q21 15q21 3.802E-3 1.394E-2 4.210E-2 4.183E-2 1 11
4 12q24.1 12q24.1 5.182E-3 1.425E-2 4.303E-2
5.700E-2
 1 15
5 15q13.3 15q13.3 9.652E-3 2.124E-2
6.413E-2
1.062E-1
 1 28
6 7q35 7q35 1.922E-2 3.524E-2
1.064E-1
2.114E-1
 1 56
7 2q37.1 2q37.1 2.329E-2 3.660E-2
1.105E-1
2.562E-1
 1 68
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 78 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 12 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 249 Transient receptor potential cation channels|Ankyrin repeat domain containing genenames.org 1.112E-35 3.335E-35 6.114E-35 3.335E-35 12 28
2 403 Ankyrin repeat domain containing|BRCA1 B complex genenames.org 4.499E-9 6.748E-9 1.237E-8 1.350E-8 6 242
3 667 Nudix hydrolase family genenames.org 1.572E-2 1.572E-2 2.882E-2 4.716E-2 1 24

13: Coexpression [Display Chart] 12 input genes in category / 517 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15525570-SuppTable1 Human Ovarian Rae04 209genes GeneSigDB 1.153E-4 3.366E-2
2.298E-1
5.963E-2
 3 191
2 M9933 Genes down-regulated in B lymphocytes with MAP3K7 [GeneID=6885] knockout: untreated versus anti IgM for 6h. MSigDB C7: Immunologic Signatures (v6.0) 1.302E-4 3.366E-2
2.298E-1
6.732E-2
 3 199

14: Coexpression Atlas [Display Chart] 12 input genes in category / 447 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ratio EB-blastocyst vs EB-fibro 2500 K5 ratio EmbryoidBody-blastocyst vs EmbryoidBody-fibro top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 5.216E-5 2.149E-2
1.436E-1
 2.332E-2 3 138
2 ratio ECTO vs SC 1000 K3 ratio induced-Ectoderm vs StemCell top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 9.617E-5 2.149E-2
1.436E-1
 4.299E-2 4 476

15: Computational [Display Chart] 4 input genes in category / 23 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 12 input genes in category / 302 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-495-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.050E-4 2.974E-2
1.870E-1
 3.171E-2 2 92
2 hsa-miR-3191:mirSVR highEffct hsa-miR-3191:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.969E-4 2.974E-2
1.870E-1
5.947E-2
 2 126
3 hsa-miR-5580-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.445E-4 3.738E-2
2.351E-1
1.644E-1
 2 210
4 hsa-miR-6501-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.497E-4 3.738E-2
2.351E-1
1.660E-1
 2 211
5 hsa-miR-122*:mirSVR highEffct hsa-miR-122*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.189E-4 3.738E-2
2.351E-1
1.869E-1
 2 224
6 hsa-miR-1224-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.379E-4 4.218E-2
2.653E-1
2.531E-1
 2 261
7 hsa-miR-663b:mirSVR highEffct hsa-miR-663b:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.903E-4 4.273E-2
2.687E-1
2.991E-1
 2 284
Show 2 more annotations

17: Drug [Display Chart] 12 input genes in category / 2311 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000001254 menthol Stitch 1.519E-26 3.509E-23 2.921E-22 3.509E-23 11 87
2 CID000104865 bosentan Stitch 1.506E-25 1.740E-22 1.449E-21 3.481E-22 11 106
3 CID000452543 4 alpha-phorbol 12,13-didecanoate Stitch 3.051E-21 2.350E-18 1.956E-17 7.051E-18 9 70
4 CID003035862 PPAHV Stitch 1.529E-17 8.836E-15 7.354E-14 3.534E-14 5 5
5 CID000023982 gadolinium Stitch 5.186E-17 2.397E-14 1.995E-13 1.199E-13 9 199
6 CID000168297 C13932 Stitch 7.118E-17 2.742E-14 2.282E-13 1.645E-13 9 206
7 CID000636975 drimanial Stitch 9.174E-17 3.029E-14 2.521E-13 2.120E-13 5 6
8 CID000002537 Camphor Stitch 1.634E-16 4.720E-14 3.928E-13 3.776E-13 7 52
9 CID000037839 isovelleral Stitch 3.210E-16 8.243E-14 6.860E-13 7.419E-13 5 7
10 CID000001598 2-aminoethyl diphenylborinate Stitch 3.785E-16 8.747E-14 7.280E-13 8.747E-13 8 128
11 CID000002548 AC1L1DXE Stitch 2.128E-15 4.470E-13 3.721E-12 4.917E-12 9 299
12 CID002733484 capsazepine Stitch 5.498E-15 1.059E-12 8.812E-12 1.270E-11 7 84
13 CID000439200 AC1L96VB Stitch 9.925E-15 1.764E-12 1.469E-11 2.294E-11 8 191
14 CID005148062 CID5148062 Stitch 1.209E-14 1.996E-12 1.661E-11 2.794E-11 5 12
15 CID000442082 C09179 Stitch 1.518E-14 2.339E-12 1.947E-11 3.509E-11 6 39
16 CID000007628 borate Stitch 1.675E-14 2.419E-12 2.013E-11 3.870E-11 7 98
17 CID000005481 tinyatoxin Stitch 3.055E-14 3.922E-12 3.264E-11 7.060E-11 5 14
18 CID000072503 polygodial Stitch 3.055E-14 3.922E-12 3.264E-11 7.060E-11 5 14
19 CID000162824 resiniferonol Stitch 1.306E-13 1.589E-11 1.322E-10 3.018E-10 5 18
20 CID000031211 zingerone Stitch 1.772E-13 2.048E-11 1.704E-10 4.095E-10 5 19
21 CID000072294 phorbol-12,13-dibenzoate Stitch 2.362E-13 2.599E-11 2.163E-10 5.459E-10 5 20
22 CID006483057 noladin ether Stitch 3.099E-13 3.256E-11 2.710E-10 7.163E-10 5 21
23 CID000104826 resiniferatoxin Stitch 4.202E-13 4.222E-11 3.514E-10 9.712E-10 6 66
24 CID000042760 AC1L28IG Stitch 6.469E-13 6.229E-11 5.184E-10 1.495E-9 5 24
25 CID000003873 rac Lafutidine Stitch 8.084E-13 7.473E-11 6.220E-10 1.868E-9 5 25
26 CID000122731 Virginiamycin S1 Stitch 1.494E-12 1.328E-10 1.105E-9 3.453E-9 5 28
27 CID000099644 NSC 255317 Stitch 2.166E-12 1.854E-10 1.543E-9 5.005E-9 5 30
28 CID005282105 N-arachidonoyl-dopamine Stitch 8.729E-12 7.205E-10 5.997E-9 2.017E-8 5 39
29 CID005282106 N-oleoyldopamine Stitch 1.438E-11 1.123E-9 9.348E-9 3.323E-8 4 11
30 CID000026346 cannabidiol Stitch 1.458E-11 1.123E-9 9.348E-9 3.369E-8 5 43
31 CID000004671 palmitoylethanolamide Stitch 1.644E-11 1.226E-9 1.020E-8 3.800E-8 5 44
32 ctd:D002118 Calcium CTD 2.110E-11 1.524E-9 1.268E-8 4.877E-8 8 495
33 CID000003473 AC1L1G0K Stitch 2.884E-11 1.960E-9 1.631E-8 6.664E-8 5 49
34 CID000001930 elaidamide Stitch 2.884E-11 1.960E-9 1.631E-8 6.664E-8 5 49
35 CID000001293 R1-methanandamide Stitch 4.335E-11 2.863E-9 2.382E-8 1.002E-7 5 53
36 CID000104974 SR 48968 Stitch 6.914E-11 4.438E-9 3.694E-8 1.598E-7 5 58
37 ctd:C109986 2-aminoethoxydiphenyl borate CTD 8.969E-11 5.602E-9 4.663E-8 2.073E-7 5 61
38 CID000178033 Russian VX Stitch 9.754E-11 5.932E-9 4.937E-8 2.254E-7 5 62
39 CID000004840 C17H19NO3 Stitch 1.059E-10 6.276E-9 5.224E-8 2.448E-7 5 63
40 CID003661571 AC1MU7EP Stitch 1.108E-10 6.401E-9 5.327E-8 2.560E-7 3 3
41 CID000055582 Neuromedin L. Stitch 1.691E-10 9.531E-9 7.933E-8 3.908E-7 5 69
42 CID000002125 AM251 Stitch 1.821E-10 9.784E-9 8.143E-8 4.207E-7 5 70
43 CID003081355 SR144528 Stitch 1.821E-10 9.784E-9 8.143E-8 4.207E-7 5 70
44 CID000151289 evodiamine Stitch 2.258E-10 1.186E-8 9.869E-8 5.217E-7 5 73
45 CID000303988 NSC-194805 Stitch 6.577E-10 3.378E-8 2.811E-7 1.520E-6 5 90
46 CID000070709 non-amide Stitch 1.107E-9 5.563E-8 4.630E-7 2.559E-6 3 5
47 CID000002788 clioquinol Stitch 2.183E-9 1.044E-7 8.690E-7 5.046E-6 5 114
48 CID000005971 mustard oil Stitch 2.183E-9 1.044E-7 8.690E-7 5.046E-6 5 114
49 CID005317148 albaconol Stitch 2.214E-9 1.044E-7 8.690E-7 5.116E-6 3 6
50 CID000001541 2-arachidonoylglycerol (2-AG Stitch 2.713E-9 1.254E-7 1.044E-6 6.270E-6 5 119
Show 45 more annotations

18: Disease [Display Chart] 12 input genes in category / 320 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0740265 Acid-base disorders DisGeNET BeFree 5.027E-7 1.609E-4 1.021E-3 1.609E-4 2 2
2 C0240327 Taste, Metallic DisGeNET BeFree 1.507E-6 2.412E-4 1.531E-3 4.824E-4 2 3
3 C0009269 Cold intolerance DisGeNET BeFree 1.053E-5 1.031E-3 6.542E-3 3.371E-3 2 7
4 C0154723 Migraine with Aura DisGeNET Curated 1.513E-5 1.031E-3 6.542E-3 4.842E-3 3 68
5 C0234245 Visceral Pain DisGeNET BeFree 1.804E-5 1.031E-3 6.542E-3 5.774E-3 2 9
6 C0036280 Burn scar DisGeNET BeFree 2.255E-5 1.031E-3 6.542E-3 7.215E-3 2 10
7 C0010201 Chronic cough DisGeNET BeFree 2.255E-5 1.031E-3 6.542E-3 7.215E-3 2 10
8 C0184567 Acute onset pain DisGeNET BeFree 4.552E-5 1.821E-3 1.156E-2 1.457E-2 2 14
9 C0020429 Hyperalgesia DisGeNET Curated 6.579E-5 2.339E-3 1.485E-2 2.105E-2 3 111
10 C0033774 Pruritus DisGeNET Curated 8.094E-5 2.590E-3 1.644E-2 2.590E-2 3 119
11 C1535950 Gastrointestinal inflammation DisGeNET Curated 1.047E-4 3.047E-3 1.934E-2 3.352E-2 2 21
12 C0600040 Chronic interstitial cystitis DisGeNET BeFree 1.494E-4 3.984E-3 2.528E-2 4.780E-2 2 25
13 C0030193 Pain DisGeNET Curated 2.920E-4 4.157E-3 2.639E-2
9.345E-2
 4 472
14 C0085648 Synovial Cyst DisGeNET BeFree 3.864E-4 4.157E-3 2.639E-2
1.237E-1
 3 202
15 C1258666 Myxoid cyst DisGeNET BeFree 3.977E-4 4.157E-3 2.639E-2
1.273E-1
 3 204
16 C0020438 Hypercalciuria DisGeNET Curated 4.674E-4 4.157E-3 2.639E-2
1.496E-1
 2 44
17 C0282488 Interstitial Cystitis DisGeNET Curated 4.889E-4 4.157E-3 2.639E-2
1.565E-1
 2 45
18 C0149931 Migraine Disorders DisGeNET Curated 6.629E-4 4.157E-3 2.639E-2
2.121E-1
 3 243
19 cv:C2609071 Palmoplantar keratoderma, mutilating, with periorificial keratotic plaques Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
20 OMIN:613216 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C; CSNB1C OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
21 cv:C0432227 Brachyrachia (short spine dysplasia) Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
22 C4225339 PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC, FOCAL 2 DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
23 C0278141 Excruciating pain DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
24 OMIN:113500 BRACHYOLMIA TYPE 3 OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
25 cv:C1847406 Digital arthropathy-brachydactyly, familial Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
26 C1565106 Headache Disorders, Primary DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
27 C0432227 Brachyolmia Type 3 DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
28 C1868616 Parastremmatic dwarfism DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
29 C0265281 Metatropic dwarfism DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
30 C0429219 Gastrointestinal sensation DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
31 cv:C0265280 Spondylometaphyseal dysplasia, Kozlowski type Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
32 OMIN:105500 AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 1 OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
33 C3159322 SPONDYLOEPIPHYSEAL DYSPLASIA, MAROTEAUX TYPE DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
34 C0520962 Localized pain DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
35 OMIN:181405 SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY; SPSMA OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
36 C0268005 Hyposmolality syndrome DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
37 C3150755 SODIUM SERUM LEVEL QUANTITATIVE TRAIT LOCUS 1 DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
38 C2750747 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
39 OMIN:606071 HEREDITARY MOTOR AND SENSORY NEUROPATHY, TYPE IIC; HMSN2C OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
40 C2079540 Charcot-Marie-Tooth disease, Type 2C DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
41 C0346041 Tumor of dermis DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
42 cv:C0265281 Metatrophic dysplasia Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
43 C1847406 Digital Arthropathy-Brachydactyly, Familial DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
44 OMIN:156530 METATROPIC DYSPLASIA OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
45 cv:C1868616 Parastremmatic dwarfism Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
46 C0234244 Tissue Pain DisGeNET BeFree 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
47 cv:C2079540 Charcot-Marie-Tooth disease type 2C Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
48 OMIN:613508 SODIUM SERUM LEVEL QUANTITATIVE TRAIT LOCUS 1; SSQTL1 OMIM 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
49 cv:C3150755 Sodium serum level quantitative trait locus 1 Clinical Variations 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
50 C0751335 Scapuloperoneal Form of Spinal Muscular Atrophy DisGeNET Curated 7.405E-4 4.157E-3 2.639E-2
2.370E-1
 1 1
Show 45 more annotations