Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc65_5, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 5 input genes in category / 74 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070403 NAD+ binding 6.828E-17 9.026E-16 4.412E-15 5.053E-15 5 13
2 GO:0043864 indoleacetamide hydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
3 GO:0008418 protein-N-terminal asparagine amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
4 GO:0034876 isonicotinic acid hydrazide hydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
5 GO:0034576 N-isopropylacetanilide amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
6 GO:0047419 N-acetylgalactosamine-6-phosphate deacetylase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
7 GO:0043747 N2-acetyl-L-lysine deacetylase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
8 GO:0034571 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
9 GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
10 GO:0043909 N-acetylcitrulline deacetylase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
11 GO:0034573 didemethylisoproturon amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
12 GO:0018749 (3,5-dichlorophenylurea)acetate amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
13 GO:0034882 cis-aconitamide amidase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
14 GO:0034885 gamma-N-formylaminovinylacetate hydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
15 GO:0018748 iprodione amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
16 GO:0052773 diacetylchitobiose deacetylase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
17 GO:0052790 chitooligosaccharide deacetylase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
18 GO:0043748 O-succinylbenzoate synthase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
19 GO:0034781 N-cyclohexylformamide amidohydrolase activity 2.318E-16 9.026E-16 4.412E-15 1.715E-14 5 16
20 GO:0003950 NAD+ ADP-ribosyltransferase activity 3.490E-15 1.291E-14 6.312E-14 2.583E-13 5 26
21 GO:0016763 transferase activity, transferring pentosyl groups 2.027E-13 7.142E-13 3.491E-12 1.500E-11 5 56
22 GO:0051287 NAD binding 2.222E-13 7.472E-13 3.653E-12 1.644E-11 5 57
23 GO:0019213 deacetylase activity 3.729E-13 1.200E-12 5.865E-12 2.760E-11 5 63
24 GO:0016836 hydro-lyase activity 4.742E-13 1.462E-12 7.146E-12 3.509E-11 5 66
25 GO:0016835 carbon-oxygen lyase activity 1.960E-12 5.803E-12 2.836E-11 1.451E-10 5 87
26 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.332E-12 6.453E-12 3.154E-11 1.726E-10 5 90
27 GO:0034979 NAD-dependent protein deacetylase activity 2.355E-12 6.453E-12 3.154E-11 1.742E-10 4 17
28 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2.932E-11 7.750E-11 3.788E-10 2.170E-9 5 148
29 GO:0052689 carboxylic ester hydrolase activity 4.782E-11 1.220E-10 5.964E-10 3.539E-9 5 163
30 GO:0050662 coenzyme binding 1.095E-10 2.700E-10 1.320E-9 8.100E-9 5 192
31 GO:0016829 lyase activity 1.184E-10 2.820E-10 1.379E-9 8.760E-9 5 195
32 GO:0033558 protein deacetylase activity 1.220E-10 2.820E-10 1.379E-9 9.025E-9 4 43
33 GO:0048037 cofactor binding 6.953E-10 1.559E-9 7.622E-9 5.145E-8 5 277
34 GO:0016757 transferase activity, transferring glycosyl groups 1.167E-9 2.540E-9 1.241E-8 8.635E-8 5 307
35 GO:0017136 NAD-dependent histone deacetylase activity 5.166E-9 1.092E-8 5.339E-8 3.823E-7 3 16
36 GO:0004407 histone deacetylase activity 1.057E-7 2.172E-7 1.062E-6 7.820E-6 3 42
37 GO:0061690 lipoamidase activity 2.679E-4 4.836E-4 2.364E-3 1.983E-2 1 1
38 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) 2.679E-4 4.836E-4 2.364E-3 1.983E-2 1 1
39 GO:0036054 protein-malonyllysine demalonylase activity 2.679E-4 4.836E-4 2.364E-3 1.983E-2 1 1
40 GO:0061697 protein-glutaryllysine deglutarylase activity 2.679E-4 4.836E-4 2.364E-3 1.983E-2 1 1
41 GO:0036055 protein-succinyllysine desuccinylase activity 2.679E-4 4.836E-4 2.364E-3 1.983E-2 1 1
42 GO:0047708 biotinidase activity 5.358E-4 8.811E-4 4.307E-3 3.965E-2 1 2
43 GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) 5.358E-4 8.811E-4 4.307E-3 3.965E-2 1 2
44 GO:0032129 histone deacetylase activity (H3-K9 specific) 5.358E-4 8.811E-4 4.307E-3 3.965E-2 1 2
45 GO:0042903 tubulin deacetylase activity 5.358E-4 8.811E-4 4.307E-3 3.965E-2 1 2
46 GO:0000107 imidazoleglycerol-phosphate synthase activity 8.036E-4 1.122E-3 5.485E-3
5.947E-2
 1 3
47 GO:0018127 NAD(P)-serine ADP-ribosyltransferase activity 8.036E-4 1.122E-3 5.485E-3
5.947E-2
 1 3
48 GO:0043398 HLH domain binding 8.036E-4 1.122E-3 5.485E-3
5.947E-2
 1 3
49 GO:0034739 histone deacetylase activity (H4-K16 specific) 8.036E-4 1.122E-3 5.485E-3
5.947E-2
 1 3
50 GO:0043867 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity 8.036E-4 1.122E-3 5.485E-3
5.947E-2
 1 3
Show 45 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 766 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006471 protein ADP-ribosylation 3.526E-15 2.701E-12 1.950E-11 2.701E-12 5 26
2 GO:0034983 peptidyl-lysine deacetylation 3.492E-14 1.338E-11 9.656E-11 2.675E-11 4 7
3 GO:0006476 protein deacetylation 4.035E-12 8.322E-10 6.007E-9 3.091E-9 5 100
4 GO:0035601 protein deacylation 5.176E-12 8.322E-10 6.007E-9 3.965E-9 5 105
5 GO:0098732 macromolecule deacylation 5.432E-12 8.322E-10 6.007E-9 4.161E-9 5 106
6 GO:2000378 negative regulation of reactive oxygen species metabolic process 3.149E-10 4.021E-8 2.903E-7 2.412E-7 4 54
7 GO:0006486 protein glycosylation 7.551E-10 7.230E-8 5.219E-7 5.784E-7 5 281
8 GO:0043413 macromolecule glycosylation 7.551E-10 7.230E-8 5.219E-7 5.784E-7 5 281
9 GO:0070085 glycosylation 9.161E-10 7.797E-8 5.629E-7 7.017E-7 5 292
10 GO:0009101 glycoprotein biosynthetic process 2.627E-9 2.012E-7 1.452E-6 2.012E-6 5 360
11 GO:0009100 glycoprotein metabolic process 4.807E-9 3.347E-7 2.417E-6 3.682E-6 5 406
12 GO:0018205 peptidyl-lysine modification 6.121E-9 3.907E-7 2.821E-6 4.688E-6 5 426
13 GO:0006342 chromatin silencing 8.721E-9 5.139E-7 3.710E-6 6.680E-6 4 122
14 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1.234E-8 6.751E-7 4.874E-6 9.452E-6 3 21
15 GO:0045814 negative regulation of gene expression, epigenetic 1.394E-8 6.840E-7 4.938E-6 1.067E-5 4 137
16 GO:0070932 histone H3 deacetylation 1.429E-8 6.840E-7 4.938E-6 1.094E-5 3 22
17 GO:0010664 negative regulation of striated muscle cell apoptotic process 2.133E-8 9.612E-7 6.939E-6 1.634E-5 3 25
18 GO:2000377 regulation of reactive oxygen species metabolic process 3.915E-8 1.666E-6 1.203E-5 2.999E-5 4 177
19 GO:0010665 regulation of cardiac muscle cell apoptotic process 5.546E-8 2.236E-6 1.614E-5 4.248E-5 3 34
20 GO:0010662 regulation of striated muscle cell apoptotic process 7.200E-8 2.757E-6 1.991E-5 5.515E-5 3 37
21 GO:0010659 cardiac muscle cell apoptotic process 8.467E-8 3.088E-6 2.229E-5 6.485E-5 3 39
22 GO:0010658 striated muscle cell apoptotic process 1.063E-7 3.702E-6 2.673E-5 8.145E-5 3 42
23 GO:0010656 negative regulation of muscle cell apoptotic process 1.143E-7 3.806E-6 2.748E-5 8.755E-5 3 43
24 GO:0016458 gene silencing 1.726E-7 5.507E-6 3.976E-5 1.322E-4 4 256
25 GO:0072593 reactive oxygen species metabolic process 1.894E-7 5.802E-6 4.188E-5 1.450E-4 4 262
26 GO:0040029 regulation of gene expression, epigenetic 1.982E-7 5.840E-6 4.216E-5 1.518E-4 4 265
27 GO:0010660 regulation of muscle cell apoptotic process 4.038E-7 1.146E-5 8.270E-5 3.093E-4 3 65
28 GO:0010657 muscle cell apoptotic process 5.281E-7 1.445E-5 1.043E-4 4.046E-4 3 71
29 GO:0016575 histone deacetylation 9.782E-7 2.584E-5 1.865E-4 7.493E-4 3 87
30 GO:0071456 cellular response to hypoxia 4.384E-6 1.119E-4 8.081E-4 3.358E-3 3 143
31 GO:0036294 cellular response to decreased oxygen levels 5.062E-6 1.251E-4 9.029E-4 3.877E-3 3 150
32 GO:0071453 cellular response to oxygen levels 5.918E-6 1.417E-4 1.023E-3 4.533E-3 3 158
33 GO:0010565 regulation of cellular ketone metabolic process 9.976E-6 2.316E-4 1.672E-3 7.641E-3 3 188
34 GO:2000757 negative regulation of peptidyl-lysine acetylation 1.094E-5 2.464E-4 1.779E-3 8.377E-3 2 20
35 GO:0050796 regulation of insulin secretion 1.148E-5 2.512E-4 1.813E-3 8.792E-3 3 197
36 GO:1901984 negative regulation of protein acetylation 1.456E-5 3.098E-4 2.236E-3 1.115E-2 2 23
37 GO:0030073 insulin secretion 1.850E-5 3.829E-4 2.764E-3 1.417E-2 3 231
38 GO:0090276 regulation of peptide hormone secretion 1.947E-5 3.925E-4 2.834E-3 1.492E-2 3 235
39 GO:0002791 regulation of peptide secretion 2.074E-5 4.073E-4 2.941E-3 1.589E-2 3 240
40 GO:0042180 cellular ketone metabolic process 2.516E-5 4.817E-4 3.478E-3 1.927E-2 3 256
41 GO:0045922 negative regulation of fatty acid metabolic process 2.673E-5 4.995E-4 3.606E-3 2.048E-2 2 31
42 GO:0030072 peptide hormone secretion 3.359E-5 6.126E-4 4.423E-3 2.573E-2 3 282
43 GO:0090087 regulation of peptide transport 3.614E-5 6.358E-4 4.590E-3 2.769E-2 3 289
44 GO:0002790 peptide secretion 3.652E-5 6.358E-4 4.590E-3 2.797E-2 3 290
45 GO:0046883 regulation of hormone secretion 4.122E-5 7.016E-4 5.065E-3 3.157E-2 3 302
46 GO:0001666 response to hypoxia 4.543E-5 7.565E-4 5.461E-3 3.480E-2 3 312
47 GO:0000183 chromatin silencing at rDNA 4.709E-5 7.675E-4 5.541E-3 3.607E-2 2 41
48 GO:0036293 response to decreased oxygen levels 4.945E-5 7.892E-4 5.697E-3 3.788E-2 3 321
49 GO:0070482 response to oxygen levels 5.768E-5 9.017E-4 6.509E-3 4.418E-2 3 338
50 GO:0045599 negative regulation of fat cell differentiation 6.748E-5 1.000E-3 7.219E-3
5.169E-2
 2 49
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 45 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005677 chromatin silencing complex 1.980E-6 8.912E-5 3.917E-4 8.912E-5 2 9
2 GO:0005720 nuclear heterochromatin 4.720E-5 1.062E-3 4.667E-3 2.124E-3 2 42
3 GO:0005759 mitochondrial matrix 1.065E-4 1.597E-3 7.018E-3 4.791E-3 3 425
4 GO:0000792 heterochromatin 2.041E-4 2.296E-3 1.009E-2 9.185E-3 2 87
5 GO:0097456 terminal loop 2.623E-4 2.361E-3 1.038E-2 1.180E-2 1 1
6 GO:0030426 growth cone 8.897E-4 5.900E-3 2.593E-2 4.004E-2 2 182
7 GO:0030427 site of polarized growth 9.389E-4 5.900E-3 2.593E-2 4.225E-2 2 187
8 GO:0033553 rDNA heterochromatin 1.049E-3 5.900E-3 2.593E-2 4.720E-2 1 4
9 GO:0033010 paranodal junction 1.311E-3 6.555E-3 2.881E-2
5.900E-2
 1 5
10 GO:0043219 lateral loop 1.835E-3 8.258E-3 3.629E-2
8.258E-2
 1 7
11 GO:0072687 meiotic spindle 2.359E-3 8.846E-3 3.888E-2
1.061E-1
 1 9
12 GO:0035748 myelin sheath abaxonal region 2.359E-3 8.846E-3 3.888E-2
1.061E-1
 1 9
13 GO:0044224 juxtaparanode region of axon 2.621E-3 8.950E-3 3.934E-2
1.179E-1
 1 10
14 GO:0000790 nuclear chromatin 2.784E-3 8.950E-3 3.934E-2
1.253E-1
 2 324
15 GO:0043220 Schmidt-Lanterman incisure 3.929E-3 1.105E-2 4.857E-2
1.768E-1
 1 15
16 GO:0033270 paranode region of axon 3.929E-3 1.105E-2 4.857E-2
1.768E-1
 1 15
17 GO:0035098 ESC/E(Z) complex 4.190E-3 1.109E-2 4.875E-2
1.886E-1
 1 16
18 GO:0097386 glial cell projection 4.713E-3 1.178E-2
5.178E-2
2.121E-1
 1 18
19 GO:0043218 compact myelin 4.975E-3 1.178E-2
5.178E-2
2.239E-1
 1 19
20 GO:0000785 chromatin 6.189E-3 1.393E-2
6.121E-2
2.785E-1
 2 487
21 GO:0005719 nuclear euchromatin 7.846E-3 1.681E-2
7.389E-2
3.531E-1
 1 30
22 GO:0000791 euchromatin 1.045E-2 2.137E-2
9.394E-2
4.702E-1
 1 40
23 GO:0031519 PcG protein complex 1.175E-2 2.299E-2
1.010E-1
5.287E-1
 1 45
24 GO:0005637 nuclear inner membrane 1.461E-2 2.738E-2
1.204E-1
6.572E-1
 1 56
25 GO:0072686 mitotic spindle 1.668E-2 3.002E-2
1.319E-1
7.505E-1
 1 64
26 GO:0035097 histone methyltransferase complex 1.900E-2 3.211E-2
1.411E-1
8.552E-1
 1 73
27 GO:0044304 main axon 1.926E-2 3.211E-2
1.411E-1
8.668E-1
 1 74
28 GO:0005758 mitochondrial intermembrane space 2.055E-2 3.303E-2
1.452E-1
9.249E-1
 1 79
29 GO:0031970 organelle envelope lumen 2.365E-2 3.586E-2
1.576E-1
1.000E0
 1 91
30 GO:0034708 methyltransferase complex 2.390E-2 3.586E-2
1.576E-1
1.000E0
 1 92
31 GO:0016605 PML body 2.570E-2 3.731E-2
1.640E-1
1.000E0
 1 99
32 GO:0005814 centriole 2.724E-2 3.831E-2
1.684E-1
1.000E0
 1 105
33 GO:0030496 midbody 3.543E-2 4.831E-2
2.123E-1
1.000E0
 1 137
34 GO:0043204 perikaryon 3.670E-2 4.858E-2
2.135E-1
1.000E0
 1 142
35 GO:0044450 microtubule organizing center part 3.797E-2 4.882E-2
2.146E-1
1.000E0
 1 147
Show 30 more annotations

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 383 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004024 aneuploidy 3.952E-4 4.622E-2
3.017E-1
1.514E-1
 2 66
2 MP:0010946 hyperpnea 4.829E-4 4.622E-2
3.017E-1
1.849E-1
 1 1
3 MP:0012298 hypoactivity in response to feed restriction 4.829E-4 4.622E-2
3.017E-1
1.849E-1
 1 1
4 MP:0003702 abnormal chromosome morphology 5.806E-4 4.622E-2
3.017E-1
2.224E-1
 2 80
5 MP:0004023 abnormal chromosome number 7.023E-4 4.622E-2
3.017E-1
2.690E-1
 2 88
6 MP:0002175 decreased brain weight 9.241E-4 4.622E-2
3.017E-1
3.539E-1
 2 101
7 MP:0011542 abnormal urine antidiuretic hormone level 9.655E-4 4.622E-2
3.017E-1
3.698E-1
 1 2
8 MP:0011543 increased urine antidiuretic hormone level 9.655E-4 4.622E-2
3.017E-1
3.698E-1
 1 2
9 MP:0009355 increased liver triglyceride level 1.135E-3 4.830E-2
3.153E-1
4.347E-1
 2 112
Show 4 more annotations

6: Domain [Display Chart] 5 input genes in category / 11 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR003000 Sirtuin InterPro 1.092E-18 3.004E-18 9.072E-18 1.202E-17 5 7
2 PF02146 SIR2 Pfam 1.092E-18 3.004E-18 9.072E-18 1.202E-17 5 7
3 IPR026590 Ssirtuin cat dom InterPro 1.092E-18 3.004E-18 9.072E-18 1.202E-17 5 7
4 PS50305 SIRTUIN PROSITE 1.092E-18 3.004E-18 9.072E-18 1.202E-17 5 7
5 3.40.50.1220 - Gene3D 2.403E-17 5.287E-17 1.597E-16 2.643E-16 5 11
6 IPR029035 DHS-like NAD/FAD-binding dom InterPro 4.120E-17 7.553E-17 2.281E-16 4.532E-16 5 12
7 3.30.1600.10 - Gene3D 9.743E-16 1.340E-15 4.046E-15 1.072E-14 4 4
8 IPR026591 Sirtuin cat small dom InterPro 9.743E-16 1.340E-15 4.046E-15 1.072E-14 4 4
9 IPR017328 Sirtuin class I InterPro 5.698E-8 6.965E-8 2.103E-7 6.268E-7 2 2
10 IPR026587 Sirtuin class II InterPro 2.669E-4 2.669E-4 8.059E-4 2.936E-3 1 1
11 IPR027546 Sirtuin class III InterPro 2.669E-4 2.669E-4 8.059E-4 2.936E-3 1 1
Show 6 more annotations

7: Pathway [Display Chart] 5 input genes in category / 29 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 3.588E-12 1.041E-10 4.122E-10 1.041E-10 5 66
2 137972 Signaling events mediated by HDAC Class III BioSystems: Pathway Interaction Database 2.830E-7 4.103E-6 1.626E-5 8.207E-6 3 39
3 PW:0000718 p53 signaling pathway Pathway Ontology 6.410E-3 4.669E-2
1.850E-1
1.859E-1
 1 16
4 M4891 Regulation of transcriptional activity by PML MSigDB C2 BIOCARTA (v6.0) 6.810E-3 4.669E-2
1.850E-1
1.975E-1
 1 17
5 1269873 RORA activates gene expression BioSystems: REACTOME 1.120E-2 4.669E-2
1.850E-1
3.247E-1
 1 28
6 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 1.358E-2 4.669E-2
1.850E-1
3.939E-1
 1 34
7 1268841 Transcriptional activation of mitochondrial biogenesis BioSystems: REACTOME 1.794E-2 4.669E-2
1.850E-1
5.204E-1
 1 45
8 138036 FoxO family signaling BioSystems: Pathway Interaction Database 1.913E-2 4.669E-2
1.850E-1
5.548E-1
 1 48
9 138027 Regulation of Androgen receptor activity BioSystems: Pathway Interaction Database 1.992E-2 4.669E-2
1.850E-1
5.778E-1
 1 50
10 1268839 Mitochondrial biogenesis BioSystems: REACTOME 2.150E-2 4.669E-2
1.850E-1
6.236E-1
 1 54
11 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 2.229E-2 4.669E-2
1.850E-1
6.465E-1
 1 56
12 1340713 Longevity regulating pathway - multiple species BioSystems: KEGG 2.466E-2 4.669E-2
1.850E-1
7.150E-1
 1 62
13 1059538 Central carbon metabolism in cancer BioSystems: KEGG 2.584E-2 4.669E-2
1.850E-1
7.493E-1
 1 65
14 547607 Amphetamine addiction BioSystems: KEGG 2.702E-2 4.669E-2
1.850E-1
7.835E-1
 1 68
15 1269738 SIRT1 negatively regulates rRNA Expression BioSystems: REACTOME 2.780E-2 4.669E-2
1.850E-1
8.063E-1
 1 70
16 1270425 Regulation of HSF1-mediated heat shock response BioSystems: REACTOME 2.780E-2 4.669E-2
1.850E-1
8.063E-1
 1 70
17 1269871 Circadian Clock BioSystems: REACTOME 2.820E-2 4.669E-2
1.850E-1
8.177E-1
 1 71
18 137934 E2F transcription factor network BioSystems: Pathway Interaction Database 2.898E-2 4.669E-2
1.850E-1
8.404E-1
 1 73
19 P00059 p53 pathway PantherDB 3.133E-2 4.782E-2
1.895E-1
9.086E-1
 1 79
20 1270421 Cellular response to heat stress BioSystems: REACTOME 3.524E-2 4.867E-2
1.928E-1
1.000E0
 1 89
21 1319989 Longevity regulating pathway BioSystems: KEGG 3.524E-2 4.867E-2
1.928E-1
1.000E0
 1 89
Show 16 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 2308 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10381378 Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Pubmed 1.477E-21 3.409E-18 2.837E-17 3.409E-18 5 5
2 17456799 Sirtuin functions in health and disease. Pubmed 8.862E-21 1.023E-17 8.510E-17 2.045E-17 5 6
3 16079181 Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Pubmed 3.102E-20 1.432E-17 1.191E-16 7.159E-17 5 7
4 26701732 Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium. Pubmed 3.102E-20 1.432E-17 1.191E-16 7.159E-17 5 7
5 10873683 Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Pubmed 3.102E-20 1.432E-17 1.191E-16 7.159E-17 5 7
6 20644252 Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. Pubmed 1.861E-19 7.159E-17 5.957E-16 4.295E-16 5 9
7 18824292 HDAC family: What are the cancer relevant targets? Pubmed 1.265E-17 4.172E-15 3.472E-14 2.921E-14 5 18
8 26767982 Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Pubmed 3.006E-17 8.671E-15 7.216E-14 6.937E-14 5 21
9 25361925 Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. Pubmed 2.820E-16 7.232E-14 6.018E-13 6.509E-13 4 5
10 26472659 Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
11 27164052 The role of mitochondrial sirtuins in health and disease. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
12 25829495 Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
13 25369635 Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
14 25165814 Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
15 24464653 Distinct patterns of sirtuin expression during progression of Alzheimer's disease. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
16 18054327 Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
17 23475622 Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Pubmed 1.077E-12 1.462E-10 1.217E-9 2.486E-9 3 3
18 19410549 SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Pubmed 4.308E-12 5.233E-10 4.355E-9 9.943E-9 3 4
19 15719057 SIRT1 regulates HIV transcription via Tat deacetylation. Pubmed 4.308E-12 5.233E-10 4.355E-9 9.943E-9 3 4
20 17715127 Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. Pubmed 2.154E-11 2.486E-9 2.068E-8 4.971E-8 3 6
21 22956852 Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. Pubmed 3.769E-11 4.142E-9 3.447E-8 8.699E-8 3 7
22 28196907 Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Pubmed 1.292E-10 1.356E-8 1.128E-7 2.982E-7 3 10
23 17923681 Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Pubmed 2.369E-10 2.377E-8 1.978E-7 5.467E-7 3 12
24 26625292 Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
25 24946089 Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
26 24107942 Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
27 11056054 Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
28 27034011 Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
29 21556116 The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
30 25915617 Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
31 26001219 Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
32 21701047 SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
33 27925196 SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
34 28808064 Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
35 25924011 Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
36 27040510 Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
37 26667041 Sirtuins-mediators of maternal obesity-induced complications in offspring? Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
38 26820517 Sirtuins 1 and 2 Are Universal Histone Deacetylases. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
39 18680753 Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
40 22796962 Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS? Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
41 23900402 Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
42 26520405 The plasticizer BBP selectively inhibits epigenetic regulator sirtuins. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
43 25341037 SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. Pubmed 1.371E-8 7.359E-7 6.124E-6 3.165E-5 2 2
44 25109285 Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
45 22585829 Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
46 27052737 PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon. Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
47 27681422 NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
48 29545174 Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
49 25404738 Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
50 26403315 Are sirtuins markers of ovarian aging? Pubmed 4.113E-8 1.531E-6 1.274E-5 9.493E-5 2 3
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 371 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SIRT3 SIRT3 interactions 2.671E-7 9.911E-5 6.437E-4 9.911E-5 3 54
2 int:SIRT4 SIRT4 interactions 3.507E-6 4.336E-4 2.816E-3 1.301E-3 2 11
3 int:CMYA5 CMYA5 interactions 3.507E-6 4.336E-4 2.816E-3 1.301E-3 2 11
4 int:SKP2 SKP2 interactions 1.002E-5 9.290E-4 6.033E-3 3.716E-3 3 179
5 int:RBP1 RBP1 interactions 1.337E-5 9.923E-4 6.445E-3 4.962E-3 2 21
6 int:SIRT5 SIRT5 interactions 1.611E-5 9.960E-4 6.469E-3 5.976E-3 2 23
7 int:CWC15 CWC15 interactions 2.405E-5 1.275E-3 8.280E-3 8.924E-3 2 28
8 int:HSPD1 HSPD1 interactions 6.646E-5 2.913E-3 1.892E-2 2.466E-2 3 337
9 int:UGDH UGDH interactions 7.162E-5 2.913E-3 1.892E-2 2.657E-2 2 48
10 int:ING1 ING1 interactions 8.415E-5 2.913E-3 1.892E-2 3.122E-2 2 52
11 int:PAPOLA PAPOLA interactions 9.079E-5 2.913E-3 1.892E-2 3.368E-2 2 54
12 int:HOXB5 HOXB5 interactions 9.421E-5 2.913E-3 1.892E-2 3.495E-2 2 55
13 int:YBEY YBEY interactions 1.443E-4 4.118E-3 2.675E-2
5.354E-2
 2 68
14 int:FOXO3 FOXO3 interactions 1.900E-4 4.329E-3 2.812E-2
7.049E-2
 2 78
15 int:SIRT2 SIRT2 interactions 1.949E-4 4.329E-3 2.812E-2
7.232E-2
 2 79
16 int:FOXO1 FOXO1 interactions 1.949E-4 4.329E-3 2.812E-2
7.232E-2
 2 79
17 int:MDM2 MDM2 interactions 2.022E-4 4.329E-3 2.812E-2
7.501E-2
 3 490
18 int:PCK1 PCK1 interactions 2.100E-4 4.329E-3 2.812E-2
7.792E-2
 2 82
19 int:NFE2 NFE2 interactions 2.257E-4 4.407E-3 2.862E-2
8.374E-2
 2 85
20 int:BRD4 BRD4 interactions 3.644E-4 6.759E-3 4.390E-2
1.352E-1
 2 108
21 int:KAT2A KAT2A interactions 5.356E-4 9.461E-3
6.145E-2
1.987E-1
 2 131
22 int:NCOA3 NCOA3 interactions 7.201E-4 1.177E-2
7.643E-2
2.671E-1
 2 152
23 int:HSPA1L HSPA1L interactions 7.295E-4 1.177E-2
7.643E-2
2.707E-1
 2 153
24 int:SP140 SP140 interactions 8.471E-4 1.257E-2
8.165E-2
3.143E-1
 1 3
25 int:VWA3B VWA3B interactions 8.471E-4 1.257E-2
8.165E-2
3.143E-1
 1 3
26 int:NUDT21 NUDT21 interactions 1.075E-3 1.534E-2
9.966E-2
3.990E-1
 2 186
27 int:KAT2B KAT2B interactions 1.292E-3 1.775E-2
1.153E-1
4.792E-1
 2 204
28 int:CA5A CA5A interactions 1.412E-3 1.806E-2
1.173E-1
5.237E-1
 1 5
29 int:GBP6 GBP6 interactions 1.412E-3 1.806E-2
1.173E-1
5.237E-1
 1 5
30 int:GCKR GCKR interactions 1.694E-3 1.964E-2
1.275E-1
6.284E-1
 1 6
31 int:GSTT2B GSTT2B interactions 1.694E-3 1.964E-2
1.275E-1
6.284E-1
 1 6
32 int:MCF2L2 MCF2L2 interactions 1.694E-3 1.964E-2
1.275E-1
6.284E-1
 1 6
33 int:REG4 REG4 interactions 1.976E-3 1.981E-2
1.287E-1
7.330E-1
 1 7
34 int:METAP1D METAP1D interactions 1.976E-3 1.981E-2
1.287E-1
7.330E-1
 1 7
35 int:NEUROG2 NEUROG2 interactions 1.976E-3 1.981E-2
1.287E-1
7.330E-1
 1 7
36 int:ZNF236 ZNF236 interactions 1.976E-3 1.981E-2
1.287E-1
7.330E-1
 1 7
37 int:G6PC G6PC interactions 1.976E-3 1.981E-2
1.287E-1
7.330E-1
 1 7
38 int:HSPA9 HSPA9 interactions 2.167E-3 2.077E-2
1.349E-1
8.039E-1
 2 265
39 int:SIRT1 SIRT1 interactions 2.183E-3 2.077E-2
1.349E-1
8.099E-1
 2 266
40 int:DYRK3 DYRK3 interactions 2.258E-3 2.094E-2
1.360E-1
8.376E-1
 1 8
41 int:AKR1D1 AKR1D1 interactions 2.540E-3 2.286E-2
1.485E-1
9.422E-1
 1 9
42 int:HERC2 HERC2 interactions 2.588E-3 2.286E-2
1.485E-1
9.603E-1
 2 290
43 int:FGF10 FGF10 interactions 3.103E-3 2.559E-2
1.662E-1
1.000E0
 1 11
44 int:CERKL CERKL interactions 3.103E-3 2.559E-2
1.662E-1
1.000E0
 1 11
45 int:HIST1H3A HIST1H3A interactions 3.103E-3 2.559E-2
1.662E-1
1.000E0
 2 318
46 int:GPAM GPAM interactions 3.385E-3 2.651E-2
1.722E-1
1.000E0
 1 12
47 int:HOXB1 HOXB1 interactions 3.667E-3 2.651E-2
1.722E-1
1.000E0
 1 13
48 int:USP9Y USP9Y interactions 3.667E-3 2.651E-2
1.722E-1
1.000E0
 1 13
49 int:SCFD2 SCFD2 interactions 3.667E-3 2.651E-2
1.722E-1
1.000E0
 1 13
50 int:NUDT12 NUDT12 interactions 3.948E-3 2.651E-2
1.722E-1
1.000E0
 1 14
Show 45 more annotations

10: Cytoband [Display Chart] 4 input genes in category / 4 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p23 6p23 1.961E-3 5.378E-3 1.120E-2 7.842E-3 1 17
2 19q13 19q13 3.918E-3 5.378E-3 1.120E-2 1.567E-2 1 34
3 10q21.3 10q21.3 4.033E-3 5.378E-3 1.120E-2 1.613E-2 1 35
4 11p15.5 11p15.5 1.458E-2 1.458E-2 3.037E-2
5.831E-2
 1 127

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 31 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 938 Sirtuins genenames.org 1.265E-18 1.265E-18 1.265E-18 1.265E-18 5 7

13: Coexpression [Display Chart] 5 input genes in category / 340 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16121216-TableS2 Human Leukemia Bradbury05 23genes RelatedProteinsMC GeneSigDB 3.684E-16 6.264E-14 4.013E-13 1.253E-13 5 21
2 16121216-TableS1 Human Leukemia Bradbury05 23genes AssociatedProteinsPMBC GeneSigDB 3.684E-16 6.264E-14 4.013E-13 1.253E-13 5 21
3 M5759 Genes up-regulated in comparison of untreated macrophages versus those treated with IL1. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.761E-2
1.769E-1
2.460E-1
 2 199
4 M3631 Genes down-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after stimulation with IL12. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.761E-2
1.769E-1
2.485E-1
 2 200
5 M8568 Genes down-regulated in Th1 cells 5 days post polarization: control versus stimulated with anti-CD3 and anti-CD28. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.761E-2
1.769E-1
2.485E-1
 2 200
6 M8485 Genes down-regulated in B16 melanoma (day 3): untreated versus mock treatment during adoptive transfer therapy. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.761E-2
1.769E-1
2.485E-1
 2 200
7 M5274 Genes down-regulated in comparison of type 2 myeloid (T2M) cells treated with IL25 [GeneID=64806] versus macrophages treated with IL25 [GeneID=64806]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.761E-2
1.769E-1
2.485E-1
 2 200
8 M6351 Genes down-regulated in Vd2 gamma delta T cells: untreated versus phorbol myristate acetate and ionomycin [PubChem=4792;3733]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.761E-2
1.769E-1
2.485E-1
 2 200
9 M3636 Genes up-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after treatment with trichostatin A (TSA) [PubChem=5562]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.761E-2
1.769E-1
2.485E-1
 2 200
10 18593951-TableS2 Human Ovarian Bonome08 263genes GeneSigDB 9.564E-4 3.252E-2
2.084E-1
3.252E-1
 2 229
11 M7068 Genes whose expression in optimally debulked ovarian tumors is associated with survival prognosis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.102E-3 3.407E-2
2.183E-1
3.748E-1
 2 246
12 M19724 Genes from the lightyellow module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.375E-3 4.645E-2
2.976E-1
8.075E-1
 1 11
13 M1807 Genes important for ovulation, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.645E-2
2.976E-1
1.000E0
 1 14
14 M4276 Genes within amplicon 6p24-p22 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.645E-2
2.976E-1
1.000E0
 1 21
15 16618758-Table1 Mouse StemCell Lien06 29genes GeneSigDB 5.391E-3 4.645E-2
2.976E-1
1.000E0
 1 25
16 15073113-Table3 Human Testicular Sugimura04 30genes Teratoma GeneSigDB 5.607E-3 4.645E-2
2.976E-1
1.000E0
 1 26
17 16357148-Table1a Human Lung Noh05 43genes GeneSigDB 6.037E-3 4.645E-2
2.976E-1
1.000E0
 1 28
18 15026349-Table1a Human Lung Carson04 50genes Increase GeneSigDB 6.467E-3 4.645E-2
2.976E-1
1.000E0
 1 30
19 16804116-Table3 Human Leukemia Chng06 33genes GeneSigDB 6.467E-3 4.645E-2
2.976E-1
1.000E0
 1 30
20 M816 Top highly correlated genes positively associated with poor survival of patients with suboptimally debulked ovarian tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.682E-3 4.645E-2
2.976E-1
1.000E0
 1 31
21 M10541 Genes up-regulated in laser microdissected (LCM) samples of early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.327E-3 4.645E-2
2.976E-1
1.000E0
 1 34
22 12917207-TableS5 Human Colon Glebov03 87genes GeneSigDB 8.400E-3 4.645E-2
2.976E-1
1.000E0
 1 39
23 18803589-Table1 Human Viral Pazienza08 52genes GeneSigDB 9.473E-3 4.645E-2
2.976E-1
1.000E0
 1 44
24 17804543-Table2 Human Leukemia Achiron07 55genes GeneSigDB 1.076E-2 4.645E-2
2.976E-1
1.000E0
 1 50
25 15358818-table2 Human Stomach Yuan04 54genes GeneSigDB 1.097E-2 4.645E-2
2.976E-1
1.000E0
 1 51
26 18593951-Table1 Human Ovarian Bonome08 57genes SurvivalDebulking GeneSigDB 1.119E-2 4.645E-2
2.976E-1
1.000E0
 1 52
27 M8077 Down-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.119E-2 4.645E-2
2.976E-1
1.000E0
 1 52
28 16818640-Table1 Human Brain Foltz06 95genes GeneSigDB 1.183E-2 4.645E-2
2.976E-1
1.000E0
 1 55
29 19893992-Table1 Human Viral Bellodi-Privato09 58genes GeneSigDB 1.204E-2 4.645E-2
2.976E-1
1.000E0
 1 56
30 M1409 Cell proliferation genes up-regulated by histone deacetylase (HDAC) inhibitors SAHA and depsipeptide [PubChem=5311;5352062]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.226E-2 4.645E-2
2.976E-1
1.000E0
 1 57
31 M17866 UV only responding genes in primary fibroblasts from young donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.333E-2 4.645E-2
2.976E-1
1.000E0
 1 62
32 M10332 Genes up-regulated in hyppocampus at late postnatal stages (clusters 11 and 15). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.354E-2 4.645E-2
2.976E-1
1.000E0
 1 63
33 M14970 IRF4 [GeneID=3662] target genes up-regulated in plasmacytoid dendritic cells compared to monocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.397E-2 4.645E-2
2.976E-1
1.000E0
 1 65
34 11906190-Table1a-1 Human Colon Iizaka02 81genes GeneSigDB 1.504E-2 4.645E-2
2.976E-1
1.000E0
 1 70
35 16581771-tableS1b Mouse StemCell Si06 109genes GeneSigDB 1.568E-2 4.645E-2
2.976E-1
1.000E0
 1 73
36 18722011-SuppTable2j Human Leukemia Sanchez-Guijo08 77genes GeneSigDB 1.589E-2 4.645E-2
2.976E-1
1.000E0
 1 74
37 M1600 Genes up-regulated in the nucleus accumbens (a major reward center in the brain) after 4 weeks of cocaine [PubChem=5760] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.610E-2 4.645E-2
2.976E-1
1.000E0
 1 75
38 19525976-SuppTable5b Human Lung Chitale09 103genes GeneSigDB 1.696E-2 4.645E-2
2.976E-1
1.000E0
 1 79
39 M15837 Genes up-regulated in normal keratinocytes immortalized by infection with the high risk HPV31 (human papilloma virus) strain. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.781E-2 4.645E-2
2.976E-1
1.000E0
 1 83
40 18410693-TableS11 Human Leukemia Kiiveri08 100genes Hyperdiploid >50Parallel GeneSigDB 1.802E-2 4.645E-2
2.976E-1
1.000E0
 1 84
41 M1666 Strongly down-regulated at 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.973E-2 4.645E-2
2.976E-1
1.000E0
 1 92
42 15374877-Table1 Human StemCell Manalo05 129genes GeneSigDB 1.973E-2 4.645E-2
2.976E-1
1.000E0
 1 92
43 M2434 Transcripts dependent upon IRS1 and IRS2 [GeneID=3667, 8660] for normal expression in liver. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.100E-2 4.645E-2
2.976E-1
1.000E0
 1 98
44 M768 Genes commonly up-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.100E-2 4.645E-2
2.976E-1
1.000E0
 1 98
45 M2809 Genes up-regulated in oligodendrocytes. MSigDB C6: Oncogenic Signatures (v6.0) 2.143E-2 4.645E-2
2.976E-1
1.000E0
 1 100
46 16478745-SuppTable1-short Human Breast Sotiriou06 128genes GeneSigDB 2.228E-2 4.645E-2
2.976E-1
1.000E0
 1 104
47 M15148 Genes down-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [GeneID=1959]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.312E-2 4.645E-2
2.976E-1
1.000E0
 1 108
48 M1833 Spermatozoa genes, based on mouse models with male reproductive defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.440E-2 4.645E-2
2.976E-1
1.000E0
 1 114
49 15297395-SuppTable3 Human Lymphoma Sriuranpong04 170genes GeneSigDB 2.461E-2 4.645E-2
2.976E-1
1.000E0
 1 115
50 M2915 Genes down-regulated in skin after injection of Trypanosoma cruzi (strain Y): wildtype (BALB/c) versus INFG [GeneID=3458] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.651E-2 4.645E-2
2.976E-1
1.000E0
 1 124
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 197 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 2 input genes in category / 4 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M1706 GCM SIRT2 Neighborhood of SIRT2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.550E-3 2.146E-2 4.472E-2 3.420E-2 1 43
2 M19045 GCM IL6ST Neighborhood of IL6ST MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.073E-2 2.146E-2 4.472E-2 4.293E-2 1 54
3 M10191 GCM MAP4K4 Neighborhood of MAP4K4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.379E-2 4.433E-2
9.236E-2
1.351E-1
 1 171
4 M16395 MODULE 47 ECM and collagens. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.433E-2 4.433E-2
9.236E-2
1.773E-1
 1 225

16: MicroRNA [Display Chart] 5 input genes in category / 124 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4474-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.180E-3 3.141E-2
1.697E-1
3.943E-1
 1 46
2 hsa-miR-126-3p:Functional MTI Functional MTI miRTarbase 3.939E-3 3.141E-2
1.697E-1
4.884E-1
 1 57
3 hsa-miR-601:PITA hsa-miR-601:PITA TOP PITA 4.008E-3 3.141E-2
1.697E-1
4.970E-1
 1 58
4 GTATGAT,MIR-154:MSigDB GTATGAT,MIR-154:MSigDB MSigDB 4.353E-3 3.141E-2
1.697E-1
5.398E-1
 1 63
5 GTATGAT,MIR-487:MSigDB GTATGAT,MIR-487:MSigDB MSigDB 4.353E-3 3.141E-2
1.697E-1
5.398E-1
 1 63
6 hsa-miR-609:PITA hsa-miR-609:PITA TOP PITA 4.422E-3 3.141E-2
1.697E-1
5.483E-1
 1 64
7 hsa-miR-15b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 3.141E-2
1.697E-1
5.654E-1
 1 66
8 hsa-miR-155-3p:Functional MTI Functional MTI miRTarbase 4.698E-3 3.141E-2
1.697E-1
5.825E-1
 1 68
9 hsa-miR-1470:mirSVR highEffct hsa-miR-1470:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.042E-3 3.141E-2
1.697E-1
6.253E-1
 1 73
10 hsa-miR-217:Functional MTI Functional MTI miRTarbase 5.525E-3 3.141E-2
1.697E-1
6.851E-1
 1 80
11 hsa-miR-34a-3p:Functional MTI Functional MTI miRTarbase 5.594E-3 3.141E-2
1.697E-1
6.936E-1
 1 81
12 hsa-miR-133b:Functional MTI Functional MTI miRTarbase 5.801E-3 3.141E-2
1.697E-1
7.193E-1
 1 84
13 hsa-miR-495-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.352E-3 3.141E-2
1.697E-1
7.876E-1
 1 92
14 GTGTTGA,MIR-505:MSigDB GTGTTGA,MIR-505:MSigDB MSigDB 6.971E-3 3.141E-2
1.697E-1
8.644E-1
 1 101
15 ATGCAGT,MIR-217:MSigDB ATGCAGT,MIR-217:MSigDB MSigDB 7.178E-3 3.141E-2
1.697E-1
8.900E-1
 1 104
16 hsa-miR-543:Functional MTI Functional MTI miRTarbase 7.384E-3 3.141E-2
1.697E-1
9.156E-1
 1 107
17 hsa-miR-199b-5p:Functional MTI Functional MTI miRTarbase 7.659E-3 3.141E-2
1.697E-1
9.497E-1
 1 111
18 hsa-miR-105*:mirSVR highEffct hsa-miR-105*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.003E-3 3.141E-2
1.697E-1
9.924E-1
 1 116
19 hsa-miR-5694:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.416E-3 3.141E-2
1.697E-1
1.000E0
 1 122
20 hsa-miR-525-3p:mirSVR highEffct hsa-miR-525-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.553E-3 3.141E-2
1.697E-1
1.000E0
 1 124
21 hsa-miR-548at-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.622E-3 3.141E-2
1.697E-1
1.000E0
 1 125
22 hsa-miR-138-5p:Non-Functional MTI Non-Functional MTI miRTarbase 8.622E-3 3.141E-2
1.697E-1
1.000E0
 1 125
23 hsa-miR-1292:mirSVR highEffct hsa-miR-1292:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.691E-3 3.141E-2
1.697E-1
1.000E0
 1 126
24 hsa-miR-524-3p:mirSVR highEffct hsa-miR-524-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.759E-3 3.141E-2
1.697E-1
1.000E0
 1 127
25 hsa-miR-302a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.759E-3 3.141E-2
1.697E-1
1.000E0
 1 127
26 hsa-miR-502-5p:PITA hsa-miR-502-5p:PITA TOP PITA 8.828E-3 3.141E-2
1.697E-1
1.000E0
 1 128
27 hsa-miR-99b*:mirSVR highEffct hsa-miR-99b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.966E-3 3.141E-2
1.697E-1
1.000E0
 1 130
28 TGTATGA,MIR-485-3P:MSigDB TGTATGA,MIR-485-3P:MSigDB MSigDB 9.309E-3 3.141E-2
1.697E-1
1.000E0
 1 135
29 hsa-miR-449b-5p:Functional MTI Functional MTI miRTarbase 9.653E-3 3.141E-2
1.697E-1
1.000E0
 1 140
30 hsa-miR-331-5p:PITA hsa-miR-331-5p:PITA TOP PITA 9.790E-3 3.141E-2
1.697E-1
1.000E0
 1 142
31 ACACTGG,MIR-199A:MSigDB ACACTGG,MIR-199A:MSigDB MSigDB 9.996E-3 3.141E-2
1.697E-1
1.000E0
 1 145
32 ACACTGG,MIR-199B:MSigDB ACACTGG,MIR-199B:MSigDB MSigDB 9.996E-3 3.141E-2
1.697E-1
1.000E0
 1 145
33 GACTGTT,MIR-212:MSigDB GACTGTT,MIR-212:MSigDB MSigDB 1.061E-2 3.141E-2
1.697E-1
1.000E0
 1 154
34 GACTGTT,MIR-132:MSigDB GACTGTT,MIR-132:MSigDB MSigDB 1.061E-2 3.141E-2
1.697E-1
1.000E0
 1 154
35 hsa-miR-663:mirSVR highEffct hsa-miR-663:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.082E-2 3.141E-2
1.697E-1
1.000E0
 1 157
36 hsa-miR-1908:mirSVR highEffct hsa-miR-1908:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.103E-2 3.141E-2
1.697E-1
1.000E0
 1 160
37 hsa-miR-449a:Functional MTI Functional MTI miRTarbase 1.109E-2 3.141E-2
1.697E-1
1.000E0
 1 161
38 hsa-miR-216a-5p:Functional MTI Functional MTI miRTarbase 1.116E-2 3.141E-2
1.697E-1
1.000E0
 1 162
39 hsa-miR-22-3p:Functional MTI Functional MTI miRTarbase 1.123E-2 3.141E-2
1.697E-1
1.000E0
 1 163
40 hsa-miR-199a-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.144E-2 3.141E-2
1.697E-1
1.000E0
 1 166
41 hsa-miR-342-3p:PITA hsa-miR-342-3p:PITA TOP PITA 1.151E-2 3.141E-2
1.697E-1
1.000E0
 1 167
42 hsa-miR-208a:mirSVR highEffct hsa-miR-208a:mirSVR conserved highEffect-0.5 MicroRNA.org 1.233E-2 3.141E-2
1.697E-1
1.000E0
 1 179
43 GTATTAT,MIR-369-3P:MSigDB GTATTAT,MIR-369-3P:MSigDB MSigDB 1.308E-2 3.141E-2
1.697E-1
1.000E0
 1 190
44 hsa-miR-558:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.349E-2 3.141E-2
1.697E-1
1.000E0
 1 196
45 hsa-miR-3160-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.356E-2 3.141E-2
1.697E-1
1.000E0
 1 197
46 CACCAGC,MIR-138:MSigDB CACCAGC,MIR-138:MSigDB MSigDB 1.377E-2 3.141E-2
1.697E-1
1.000E0
 1 200
47 ATATGCA,MIR-448:MSigDB ATATGCA,MIR-448:MSigDB MSigDB 1.397E-2 3.141E-2
1.697E-1
1.000E0
 1 203
48 AAAGGGA,MIR-204:MSigDB AAAGGGA,MIR-204:MSigDB MSigDB 1.452E-2 3.141E-2
1.697E-1
1.000E0
 1 211
49 AAAGGGA,MIR-211:MSigDB AAAGGGA,MIR-211:MSigDB MSigDB 1.452E-2 3.141E-2
1.697E-1
1.000E0
 1 211
50 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 1.472E-2 3.141E-2
1.697E-1
1.000E0
 1 214
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 2536 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000005269 splitomicin Stitch 1.049E-12 2.660E-9 2.239E-8 2.660E-9 4 17
2 CID005512209 S)-sirtinol Stitch 2.043E-11 2.591E-8 2.180E-7 5.181E-8 4 34
3 CID000439200 AC1L96VB Stitch 3.880E-11 3.280E-8 2.760E-7 9.840E-8 5 191
4 CID000001049 pyridine Stitch 1.203E-10 7.628E-8 6.419E-7 3.051E-7 5 239
5 CID000000936 vitamin B Stitch 3.475E-10 1.762E-7 1.483E-6 8.812E-7 5 295
6 ctd:C008971 polymarcine CTD 6.040E-10 2.438E-7 2.052E-6 1.532E-6 3 10
7 CID000000177 acetaldehyde Stitch 6.891E-10 2.438E-7 2.052E-6 1.748E-6 5 338
8 CID000000940 nicotinamide ribose Stitch 7.692E-10 2.438E-7 2.052E-6 1.951E-6 4 82
9 CID000030243 adenosine diphosphoribose Stitch 1.284E-9 3.407E-7 2.867E-6 3.255E-6 4 93
10 CID000000181 AC1Q68Z5 Stitch 1.344E-9 3.407E-7 2.867E-6 3.407E-6 5 386
11 ctd:D008687 Metformin CTD 1.689E-9 3.895E-7 3.278E-6 4.284E-6 5 404
12 CID000000660 dihydrocoumarin Stitch 4.875E-9 1.030E-6 8.669E-6 1.236E-5 3 19
13 ctd:C568740 salvianolic acid CTD 3.834E-8 7.479E-6 6.294E-5 9.722E-5 2 2
14 ctd:D026082 Singlet Oxygen CTD 1.150E-7 1.944E-5 1.636E-4 2.916E-4 2 3
15 CID000065768 tryptamide Stitch 1.150E-7 1.944E-5 1.636E-4 2.916E-4 2 3
16 CID000000479 pantetheine Stitch 1.468E-7 2.310E-5 1.944E-4 3.723E-4 3 57
17 CID000000988 k012 Stitch 1.548E-7 2.310E-5 1.944E-4 3.926E-4 3 58
18 CID000000232 DL-arginine Stitch 2.498E-7 3.480E-5 2.929E-4 6.336E-4 4 344
19 ctd:C013099 mancozeb CTD 2.744E-7 3.480E-5 2.929E-4 6.960E-4 3 70
20 CID000000941 NaMN Stitch 2.744E-7 3.480E-5 2.929E-4 6.960E-4 3 70
21 CID000024524 Fluor Stitch 3.384E-7 4.087E-5 3.439E-4 8.583E-4 3 75
22 ctd:C003747 urushiol CTD 3.833E-7 4.418E-5 3.718E-4 9.720E-4 2 5
23 CID000019001 dithiotreitol Stitch 6.102E-7 6.728E-5 5.662E-4 1.548E-3 4 430
24 CID000001693 4-hydroxynonenal Stitch 8.782E-7 9.280E-5 7.810E-4 2.227E-3 4 471
25 CID000467801 Apicidin Stitch 1.171E-6 1.187E-4 9.993E-4 2.969E-3 3 113
26 ctd:D009536 Niacinamide CTD 1.300E-6 1.268E-4 1.067E-3 3.297E-3 3 117
27 CID000065203 rhodamine 110 Stitch 1.379E-6 1.296E-4 1.090E-3 3.498E-3 2 9
28 CID000006861 Naam Stitch 1.724E-6 1.508E-4 1.269E-3 4.372E-3 2 10
29 CID004430533 desoxyrhaponticin Stitch 1.724E-6 1.508E-4 1.269E-3 4.372E-3 2 10
30 CID002762604 6-TAMRA Stitch 2.107E-6 1.781E-4 1.499E-3 5.343E-3 2 11
31 CID000031263 propionic anhydride Stitch 2.987E-6 2.444E-4 2.057E-3 7.576E-3 2 13
32 CID000003515 guaiazulene Stitch 5.207E-6 4.127E-4 3.473E-3 1.320E-2 2 17
33 CID000065072 homocitrulline Stitch 5.857E-6 4.487E-4 3.776E-3 1.485E-2 2 18
34 2495 DN Ethionamide [536-33-4]; Down 200; 24uM; HL60; HT HG-U133A Broad Institute CMAP Down 6.051E-6 4.487E-4 3.776E-3 1.534E-2 3 195
35 CID000000937 niacin Stitch 6.335E-6 4.487E-4 3.776E-3 1.606E-2 3 198
36 CID000012819 2-hydroxy-1-naphthaldehyde Stitch 6.546E-6 4.487E-4 3.776E-3 1.660E-2 2 19
37 CID000000675 5,6-dimethylbenzimidazole Stitch 6.546E-6 4.487E-4 3.776E-3 1.660E-2 2 19
38 ctd:D001599 Berberine CTD 7.031E-6 4.692E-4 3.949E-3 1.783E-2 3 205
39 CID011360432 NSC726617 Stitch 8.037E-6 5.226E-4 4.398E-3 2.038E-2 2 21
40 CID000000192 ADP-Rib Stitch 1.587E-5 1.006E-3 8.470E-3 4.026E-2 3 269
41 CID000123237 CF3CO Stitch 1.778E-5 1.100E-3 9.256E-3 4.509E-2 2 31
42 CID000015074 isonicotinamide Stitch 2.019E-5 1.219E-3 1.026E-2
5.119E-2
 2 33
43 CID000000628 NAAD Stitch 2.545E-5 1.501E-3 1.263E-2
6.455E-2
 2 37
44 ctd:D017382 Reactive Oxygen Species CTD 2.820E-5 1.596E-3 1.343E-2
7.152E-2
 3 326
45 CID000123952 NAADP Stitch 2.832E-5 1.596E-3 1.343E-2
7.181E-2
 2 39
46 ctd:D008344 Maneb CTD 3.428E-5 1.890E-3 1.590E-2
8.693E-2
 3 348
47 ctd:C550547 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide CTD 5.061E-5 2.731E-3 2.298E-2
1.284E-1
 2 52
48 CID000656979 O-Ln Stitch 5.876E-5 3.105E-3 2.613E-2
1.490E-1
 2 56
49 CID000092249 7-amino-4-methylcoumarin Stitch 6.527E-5 3.378E-3 2.843E-2
1.655E-1
 2 59
50 CID006098948 ISO-1 cpd Stitch 6.751E-5 3.424E-3 2.882E-2
1.712E-1
 2 60
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 192 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0220645 childhood soft tissue sarcoma DisGeNET BeFree 7.614E-7 1.462E-4 8.533E-4 1.462E-4 2 5
2 C0270952 Muscular Dystrophy, Oculopharyngeal DisGeNET Curated 2.096E-5 2.013E-3 1.175E-2 4.025E-3 2 24
3 C0023486 Prolymphocytic Leukemia DisGeNET BeFree 7.168E-5 4.588E-3 2.678E-2 1.376E-2 2 44
4 C0231341 Premature aging syndrome DisGeNET Curated 2.951E-4 9.873E-3
5.763E-2
5.665E-2
 2 89
5 C0030783 Pellagra DisGeNET BeFree 3.085E-4 9.873E-3
5.763E-2
5.924E-2
 1 1
6 C1850380 NEUTROPHIL ACTIN DYSFUNCTION DisGeNET BeFree 3.085E-4 9.873E-3
5.763E-2
5.924E-2
 1 1
7 C3887486 Interstitial lung fibrosis DisGeNET BeFree 6.001E-4 1.077E-2
6.287E-2
1.152E-1
 2 127
8 C0039503 Tendinitis DisGeNET BeFree 6.170E-4 1.077E-2
6.287E-2
1.185E-1
 1 2
9 C0155502 Benign Paroxysmal Positional Vertigo DisGeNET Curated 6.170E-4 1.077E-2
6.287E-2
1.185E-1
 1 2
10 C0043020 Wallerian Degeneration DisGeNET Curated 6.170E-4 1.077E-2
6.287E-2
1.185E-1
 1 2
11 C0796135 Renpenning syndrome 1 DisGeNET Curated 6.170E-4 1.077E-2
6.287E-2
1.185E-1
 1 2
12 C0919532 Genomic Instability DisGeNET Curated 1.234E-3 1.974E-2
1.152E-1
2.369E-1
 1 4
13 C0039101 synovial sarcoma DisGeNET Curated 1.598E-3 2.361E-2
1.378E-1
3.069E-1
 2 208
14 C0085426 Gram-Positive Bacterial Infections DisGeNET Curated 2.158E-3 2.535E-2
1.480E-1
4.144E-1
 1 7
15 C0014072 Experimental Autoimmune Encephalomyelitis DisGeNET Curated 2.158E-3 2.535E-2
1.480E-1
4.144E-1
 1 7
16 C0079773 Lymphoma, T-Cell, Cutaneous DisGeNET Curated 2.245E-3 2.535E-2
1.480E-1
4.310E-1
 2 247
17 C0004623 Bacterial Infections DisGeNET Curated 2.446E-3 2.535E-2
1.480E-1
4.697E-1
 2 258
18 C2939186 Disturbance in mood DisGeNET Curated 2.466E-3 2.535E-2
1.480E-1
4.735E-1
 1 8
19 C0007114 Malignant neoplasm of skin DisGeNET Curated 2.637E-3 2.535E-2
1.480E-1
5.062E-1
 2 268
20 C0033937 Psychoses, Drug DisGeNET Curated 2.774E-3 2.535E-2
1.480E-1
5.326E-1
 1 9
21 C3811653 Experimental Organism Basal Cell Carcinoma DisGeNET BeFree 2.997E-3 2.535E-2
1.480E-1
5.754E-1
 2 286
22 C0553980 Endomyocardial Fibrosis DisGeNET Curated 3.082E-3 2.535E-2
1.480E-1
5.918E-1
 1 10
23 C1834523 ARTHROGRYPOSIS, DISTAL, TYPE 2B DisGeNET Curated 3.082E-3 2.535E-2
1.480E-1
5.918E-1
 1 10
24 C0432291 Mandibuloacral dysostosis DisGeNET Curated 3.390E-3 2.535E-2
1.480E-1
6.508E-1
 1 11
25 C0525045 Mood Disorders DisGeNET Curated 3.578E-3 2.535E-2
1.480E-1
6.870E-1
 2 313
26 C3714534 dowling-degos disease DisGeNET Curated 3.698E-3 2.535E-2
1.480E-1
7.099E-1
 1 12
27 C0085207 Gestational Diabetes DisGeNET Curated 3.698E-3 2.535E-2
1.480E-1
7.099E-1
 1 12
28 C2931673 Ceroid lipofuscinosis, neuronal 1, infantile DisGeNET Curated 3.698E-3 2.535E-2
1.480E-1
7.099E-1
 1 12
29 C0263874 Degeneration of lumbar intervertebral disc DisGeNET BeFree 4.005E-3 2.652E-2
1.548E-1
7.690E-1
 1 13
30 C0268281 Infantile neuronal ceroid lipofuscinosis DisGeNET BeFree 4.928E-3 3.035E-2
1.772E-1
9.461E-1
 1 16
31 C0015695 Fatty Liver DisGeNET Curated 5.233E-3 3.035E-2
1.772E-1
1.000E0
 2 380
32 C0020564 Hypertrophy DisGeNET Curated 5.235E-3 3.035E-2
1.772E-1
1.000E0
 1 17
33 C0035412 Rhabdomyosarcoma DisGeNET Curated 5.533E-3 3.035E-2
1.772E-1
1.000E0
 2 391
34 C1257763 Overnutrition DisGeNET BeFree 5.542E-3 3.035E-2
1.772E-1
1.000E0
 1 18
35 C0025517 Metabolic Diseases DisGeNET Curated 5.645E-3 3.035E-2
1.772E-1
1.000E0
 2 395
36 C0015696 Fatty Liver, Alcoholic DisGeNET Curated 5.849E-3 3.035E-2
1.772E-1
1.000E0
 1 19
37 C3828416 Radiation Damage DisGeNET BeFree 5.849E-3 3.035E-2
1.772E-1
1.000E0
 1 19
38 C0273115 Lung Injury DisGeNET Curated 6.156E-3 3.040E-2
1.774E-1
1.000E0
 1 20
39 C0036939 Shared Paranoid Disorder DisGeNET Curated 6.464E-3 3.040E-2
1.774E-1
1.000E0
 1 21
40 C0878544 Cardiomyopathies DisGeNET Curated 6.752E-3 3.040E-2
1.774E-1
1.000E0
 2 433
41 C0085681 Hyperphosphatemia (disorder) DisGeNET Curated 6.770E-3 3.040E-2
1.774E-1
1.000E0
 1 22
42 C0011848 Diabetes Insipidus DisGeNET Curated 6.770E-3 3.040E-2
1.774E-1
1.000E0
 1 22
43 C0153381 Malignant neoplasm of mouth DisGeNET BeFree 6.874E-3 3.040E-2
1.774E-1
1.000E0
 2 437
44 C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 6.966E-3 3.040E-2
1.774E-1
1.000E0
 2 440
45 C0036690 Septicemia DisGeNET Curated 7.278E-3 3.105E-2
1.813E-1
1.000E0
 2 450
46 C1955934 Trichothiodystrophy Syndromes DisGeNET Curated 7.997E-3 3.199E-2
1.867E-1
1.000E0
 1 26
47 C0856727 Cholesterol gallstones DisGeNET Curated 7.997E-3 3.199E-2
1.867E-1
1.000E0
 1 26
48 C0004277 Tooth Attrition DisGeNET BeFree 7.997E-3 3.199E-2
1.867E-1
1.000E0
 1 26
49 C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 8.251E-3 3.223E-2
1.881E-1
1.000E0
 2 480
50 C2711227 Steatohepatitis DisGeNET Curated 8.486E-3 3.223E-2
1.881E-1
1.000E0
 2 487
Show 45 more annotations