Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc66_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 19 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005200 structural constituent of cytoskeleton 5.086E-4 9.663E-3 3.428E-2 9.663E-3 2 110
2 GO:0038132 neuregulin binding 1.928E-3 1.830E-2
6.492E-2
 3.663E-2 1 6
3 GO:0051010 microtubule plus-end binding 3.532E-3 1.830E-2
6.492E-2
6.711E-2
 1 11
4 GO:0031994 insulin-like growth factor I binding 3.853E-3 1.830E-2
6.492E-2
7.320E-2
 1 12
5 GO:0019215 intermediate filament binding 5.134E-3 1.867E-2
6.623E-2
9.755E-2
 1 16
6 GO:0030506 ankyrin binding 6.734E-3 1.867E-2
6.623E-2
1.279E-1
 1 21
7 GO:0003779 actin binding 6.877E-3 1.867E-2
6.623E-2
1.307E-1
 2 412
8 GO:0005520 insulin-like growth factor binding 8.970E-3 2.130E-2
7.558E-2
1.704E-1
 1 28
9 GO:0008307 structural constituent of muscle 1.311E-2 2.768E-2
9.821E-2
2.491E-1
 1 41
Show 4 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 46 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031581 hemidesmosome assembly 1.481E-12 6.813E-11 3.009E-10 6.813E-11 4 12
2 GO:0007044 cell-substrate junction assembly 7.257E-9 1.669E-7 7.372E-7 3.338E-7 4 89
3 GO:0034329 cell junction assembly 1.904E-7 2.920E-6 1.290E-5 8.759E-6 4 200
4 GO:0034330 cell junction organization 5.282E-7 6.075E-6 2.683E-5 2.430E-5 4 258
5 GO:0043588 skin development 6.366E-5 5.857E-4 2.587E-3 2.928E-3 3 278
6 GO:0008544 epidermis development 1.158E-4 7.776E-4 3.435E-3 5.327E-3 3 340
7 GO:0031424 keratinization 1.183E-4 7.776E-4 3.435E-3 5.444E-3 2 53
8 GO:0007229 integrin-mediated signaling pathway 3.811E-4 2.192E-3 9.679E-3 1.753E-2 2 95
9 GO:0030216 keratinocyte differentiation 8.019E-4 4.099E-3 1.810E-2 3.689E-2 2 138
10 GO:0009913 epidermal cell differentiation 1.673E-3 7.418E-3 3.276E-2
7.697E-2
 2 200
11 GO:0007160 cell-matrix adhesion 1.774E-3 7.418E-3 3.276E-2
8.160E-2
 2 206
12 GO:0061450 trophoblast cell migration 2.575E-3 9.871E-3 4.360E-2
1.185E-1
 1 8
13 GO:0035878 nail development 2.897E-3 1.025E-2 4.527E-2
1.332E-1
 1 9
14 GO:0031589 cell-substrate adhesion 4.270E-3 1.381E-2
6.099E-2
1.964E-1
 2 322
15 GO:0030011 maintenance of cell polarity 4.503E-3 1.381E-2
6.099E-2
2.071E-1
 1 14
16 GO:0097186 amelogenesis 7.388E-3 2.124E-2
9.382E-2
3.399E-1
 1 23
17 GO:0048333 mesodermal cell differentiation 1.091E-2 2.951E-2
1.303E-1
5.017E-1
 1 34
18 GO:0045104 intermediate filament cytoskeleton organization 1.441E-2 3.566E-2
1.575E-1
6.630E-1
 1 45
19 GO:0045103 intermediate filament-based process 1.473E-2 3.566E-2
1.575E-1
6.776E-1
 1 46
20 GO:0018149 peptide cross-linking 1.823E-2 4.062E-2
1.794E-1
8.384E-1
 1 57
21 GO:0007566 embryo implantation 1.854E-2 4.062E-2
1.794E-1
8.530E-1
 1 58
22 GO:0046847 filopodium assembly 1.950E-2 4.076E-2
1.800E-1
8.968E-1
 1 61
23 GO:0001707 mesoderm formation 2.329E-2 4.659E-2
2.058E-1
1.000E0
 1 73
24 GO:0048332 mesoderm morphogenesis 2.456E-2 4.707E-2
2.079E-1
1.000E0
 1 77
Show 19 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 47 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030056 hemidesmosome 5.726E-13 2.691E-11 1.194E-10 2.691E-11 4 10
2 GO:0009925 basal plasma membrane 2.129E-7 5.002E-6 2.220E-5 1.000E-5 3 43
3 GO:0045178 basal part of cell 7.169E-7 1.123E-5 4.984E-5 3.369E-5 3 64
4 GO:0030055 cell-substrate junction 2.856E-6 3.355E-5 1.489E-4 1.342E-4 4 403
5 GO:0005604 basement membrane 3.593E-6 3.377E-5 1.499E-4 1.689E-4 3 109
6 GO:0044420 extracellular matrix component 7.797E-6 6.108E-5 2.711E-4 3.665E-4 3 141
7 GO:0030057 desmosome 2.675E-5 1.796E-4 7.970E-4 1.257E-3 2 26
8 GO:0045111 intermediate filament cytoskeleton 4.028E-5 2.103E-4 9.335E-4 1.893E-3 3 244
9 GO:0016323 basolateral plasma membrane 4.028E-5 2.103E-4 9.335E-4 1.893E-3 3 244
10 GO:0005911 cell-cell junction 1.994E-4 9.370E-4 4.158E-3 9.370E-3 3 418
11 GO:0031012 extracellular matrix 2.383E-4 1.018E-3 4.518E-3 1.120E-2 3 444
12 GO:0031673 H zone 6.295E-4 2.465E-3 1.094E-2 2.959E-2 1 2
13 GO:0044449 contractile fiber part 1.844E-3 6.477E-3 2.875E-2
8.666E-2
 2 215
14 GO:0030016 myofibril 1.929E-3 6.477E-3 2.875E-2
9.068E-2
 2 220
15 GO:0043292 contractile fiber 2.179E-3 6.828E-3 3.030E-2
1.024E-1
 2 234
16 GO:0005938 cell cortex 2.805E-3 8.238E-3 3.656E-2
1.318E-1
 2 266
17 GO:0099568 cytoplasmic region 4.155E-3 1.149E-2
5.098E-2
1.953E-1
 2 325
18 GO:0031252 cell leading edge 5.902E-3 1.406E-2
6.238E-2
2.774E-1
 2 389
19 GO:0005925 focal adhesion 6.021E-3 1.406E-2
6.238E-2
2.830E-1
 2 393
20 GO:0005924 cell-substrate adherens junction 6.171E-3 1.406E-2
6.238E-2
2.900E-1
 2 398
21 GO:0035371 microtubule plus-end 6.280E-3 1.406E-2
6.238E-2
2.952E-1
 1 20
22 GO:0043034 costamere 6.593E-3 1.409E-2
6.251E-2
3.099E-1
 1 21
23 GO:1990752 microtubule end 8.783E-3 1.701E-2
7.547E-2
4.128E-1
 1 28
24 GO:0005912 adherens junction 9.019E-3 1.701E-2
7.547E-2
4.239E-1
 2 484
25 GO:0008305 integrin complex 9.408E-3 1.701E-2
7.547E-2
4.422E-1
 1 30
26 GO:0098636 protein complex involved in cell adhesion 9.408E-3 1.701E-2
7.547E-2
4.422E-1
 1 30
27 GO:0031672 A band 1.346E-2 2.343E-2
1.040E-1
6.327E-1
 1 43
28 GO:0001533 cornified envelope 1.502E-2 2.521E-2
1.119E-1
7.058E-1
 1 48
29 GO:0016528 sarcoplasm 2.307E-2 3.739E-2
1.659E-1
1.000E0
 1 74
30 GO:0005581 collagen trimer 2.739E-2 4.291E-2
1.904E-1
1.000E0
 1 88
Show 25 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 250 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001075 Atrophic scars 1.342E-9 3.354E-7 2.046E-6 3.354E-7 4 30
2 HP:0200097 Oral mucosal blisters 5.059E-8 6.324E-6 3.858E-5 1.265E-5 3 12
3 HP:0004552 Scarring alopecia of scalp 8.367E-8 6.973E-6 4.254E-5 2.092E-5 3 14
4 HP:0004334 Dermal atrophy 1.429E-7 8.933E-6 5.450E-5 3.573E-5 4 93
5 HP:0200037 Skin vesicle 5.278E-7 2.097E-5 1.279E-4 1.319E-4 3 25
6 HP:0000987 Atypical scarring of skin 5.561E-7 2.097E-5 1.279E-4 1.390E-4 4 130
7 HP:0008404 Nail dystrophy 6.098E-7 2.097E-5 1.279E-4 1.525E-4 4 133
8 HP:0001056 Milia 6.710E-7 2.097E-5 1.279E-4 1.677E-4 3 27
9 HP:0002293 Alopecia of scalp 1.030E-6 2.862E-5 1.746E-4 2.576E-4 3 31
10 HP:0008065 Aplasia/Hypoplasia of the skin 1.353E-6 2.921E-5 1.782E-4 3.384E-4 4 162
11 HP:0001057 Aplasia cutis congenita 1.371E-6 2.921E-5 1.782E-4 3.428E-4 3 34
12 HP:0010477 Aplasia of the bladder 1.625E-6 2.921E-5 1.782E-4 4.062E-4 2 3
13 HP:0004399 Congenital pyloric atresia 1.625E-6 2.921E-5 1.782E-4 4.062E-4 2 3
14 HP:0001030 Fragile skin 1.636E-6 2.921E-5 1.782E-4 4.089E-4 3 36
15 HP:0002164 Nail dysplasia 3.103E-6 5.172E-5 3.155E-4 7.758E-4 4 199
16 HP:0001798 Anonychia 3.472E-6 5.424E-5 3.309E-4 8.679E-4 3 46
17 HP:0008384 Aplastic/hypoplastic fingernail 3.954E-6 5.815E-5 3.548E-4 9.886E-4 3 48
18 HP:0005984 Elevated maternal serum alpha-fetoprotein 5.413E-6 7.454E-5 4.548E-4 1.353E-3 2 5
19 HP:0007556 Plantar hyperkeratosis 5.665E-6 7.454E-5 4.548E-4 1.416E-3 3 54
20 HP:0003340 Abnormal dermatological laboratory findings 8.117E-6 9.663E-5 5.895E-4 2.029E-3 2 6
21 HP:0003341 Junctional split 8.117E-6 9.663E-5 5.895E-4 2.029E-3 2 6
22 HP:0006297 Hypoplasia of dental enamel 9.959E-6 1.132E-4 6.904E-4 2.490E-3 3 65
23 HP:0000796 Urethral obstruction 1.043E-5 1.134E-4 6.917E-4 2.608E-3 3 66
24 HP:0001060 Axillary pterygium 1.136E-5 1.183E-4 7.219E-4 2.840E-3 2 7
25 HP:0001596 Alopecia 1.940E-5 1.736E-4 1.059E-3 4.851E-3 3 81
26 HP:0000070 Ureterocele 1.946E-5 1.736E-4 1.059E-3 4.866E-3 2 9
27 HP:0012227 Urethral stricture 1.946E-5 1.736E-4 1.059E-3 4.866E-3 2 9
28 HP:0006089 Palmar hyperhidrosis 1.946E-5 1.736E-4 1.059E-3 4.866E-3 2 9
29 HP:0004400 Abnormality of the pylorus 2.014E-5 1.736E-4 1.059E-3 5.034E-3 3 82
30 HP:0000685 Hypoplasia of teeth 2.089E-5 1.741E-4 1.062E-3 5.222E-3 3 83
31 HP:0010476 Aplasia/Hypoplasia of the bladder 2.432E-5 1.900E-4 1.159E-3 6.081E-3 2 10
32 HP:0002041 Intractable diarrhea 2.432E-5 1.900E-4 1.159E-3 6.081E-3 2 10
33 HP:0100872 Abnormality of the plantar skin of foot 2.668E-5 2.021E-4 1.233E-3 6.669E-3 3 90
34 HP:0001597 Abnormality of the nail 3.221E-5 2.369E-4 1.445E-3 8.053E-3 4 356
35 HP:0100699 Scarring 4.890E-5 3.493E-4 2.131E-3 1.223E-2 4 395
36 HP:0008066 Abnormal blistering of the skin 6.189E-5 4.298E-4 2.622E-3 1.547E-2 3 119
37 HP:0200041 Skin erosion 7.336E-5 4.827E-4 2.944E-3 1.834E-2 2 17
38 HP:0001802 Absent toenail 7.336E-5 4.827E-4 2.944E-3 1.834E-2 2 17
39 HP:0011495 Abnormal corneal epithelium morphology 1.097E-4 7.032E-4 4.290E-3 2.743E-2 3 144
40 HP:0001817 Absent fingernail 1.132E-4 7.072E-4 4.314E-3 2.829E-2 2 21
41 HP:0008386 Aplasia/Hypoplasia of the nails 1.240E-4 7.560E-4 4.612E-3 3.099E-2 3 150
42 HP:0001808 Fragile nails 1.362E-4 7.771E-4 4.741E-3 3.406E-2 2 23
43 HP:0001231 Abnormality of the fingernails 1.368E-4 7.771E-4 4.741E-3 3.419E-2 3 155
44 HP:0000682 Abnormality of dental enamel 1.368E-4 7.771E-4 4.741E-3 3.419E-2 3 155
45 HP:0000670 Carious teeth 1.619E-4 8.997E-4 5.489E-3 4.049E-2 3 164
46 HP:3000050 Abnormality of odontoid tissue 2.034E-4 1.106E-3 6.745E-3
5.086E-2
 3 177
47 HP:0001059 Pterygium 2.664E-4 1.417E-3 8.645E-3
6.661E-2
 2 32
48 HP:0000075 Renal duplication 3.380E-4 1.760E-3 1.074E-2
8.450E-2
 2 36
49 HP:0008661 Urethral stenosis 3.572E-4 1.821E-3 1.111E-2
8.931E-2
 2 37
50 HP:0000126 Hydronephrosis 3.736E-4 1.821E-3 1.111E-2
9.339E-2
 3 217
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 4 input genes in category / 113 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011160 dermal-epidermal separation 3.131E-6 3.474E-4 1.844E-3 3.539E-4 2 8
2 MP:0011159 abnormal epidermal-dermal junction morphology 6.149E-6 3.474E-4 1.844E-3 6.948E-4 2 11
3 MP:0001208 blistering 4.528E-5 1.706E-3 9.055E-3 5.117E-3 2 29
4 MP:0008814 decreased nerve conduction velocity 1.308E-4 3.696E-3 1.962E-2 1.478E-2 2 49
5 MP:0001216 abnormal epidermal layer morphology 1.706E-4 3.828E-3 2.032E-2 1.928E-2 3 366
6 MP:0001231 abnormal epidermis stratum basale morphology 2.033E-4 3.828E-3 2.032E-2 2.297E-2 2 61
7 MP:0005403 abnormal nerve conduction 3.077E-4 4.788E-3 2.542E-2 3.477E-2 2 75
8 MP:0009473 abnormal skin exfoliation 3.863E-4 4.788E-3 2.542E-2 4.365E-2 1 1
9 MP:0001232 absent epidermis stratum basale 3.863E-4 4.788E-3 2.542E-2 4.365E-2 1 1
10 MP:0002655 abnormal keratinocyte morphology 4.237E-4 4.788E-3 2.542E-2 4.788E-2 2 88
11 MP:0003453 abnormal keratinocyte physiology 7.230E-4 7.427E-3 3.943E-2
8.170E-2
 2 115
12 MP:0009827 skin detachment 1.159E-3 1.091E-2
5.792E-2
1.309E-1
 1 3
13 MP:0030578 decreased keratinocyte adhesion 2.316E-3 2.013E-2
1.069E-1
2.617E-1
 1 6
14 MP:0020416 decreased fibroblast chemotaxis 2.702E-3 2.082E-2
1.106E-1
3.053E-1
 1 7
15 MP:0005404 abnormal axon morphology 2.764E-3 2.082E-2
1.106E-1
3.124E-1
 2 226
16 MP:0030576 abnormal keratinocyte adhesion 3.087E-3 2.180E-2
1.158E-1
3.488E-1
 1 8
17 MP:0020415 abnormal fibroblast chemotaxis 3.473E-3 2.308E-2
1.225E-1
3.924E-1
 1 9
18 MP:0001191 abnormal skin condition 3.869E-3 2.429E-2
1.289E-1
4.371E-1
 2 268
19 MP:0009594 abnormal corneocyte envelope morphology 4.628E-3 2.752E-2
1.461E-1
5.230E-1
 1 12
20 MP:0002272 abnormal nervous system electrophysiology 6.866E-3 3.760E-2
1.996E-1
7.758E-1
 2 359
21 MP:0005501 abnormal skin physiology 7.016E-3 3.760E-2
1.996E-1
7.928E-1
 2 363
22 MP:0030605 abnormal corneocyte morphology 7.320E-3 3.760E-2
1.996E-1
8.272E-1
 1 19
23 MP:0004121 abnormal sarcolemma morphology 7.704E-3 3.785E-2
2.010E-1
8.706E-1
 1 20
24 MP:0000540 abnormal urinary bladder urothelium morphology 8.089E-3 3.808E-2
2.022E-1
9.140E-1
 1 21
25 MP:0003081 abnormal soleus morphology 9.240E-3 4.014E-2
2.131E-1
1.000E0
 1 24
26 MP:0009414 skeletal muscle fiber necrosis 1.001E-2 4.014E-2
2.131E-1
1.000E0
 1 26
27 MP:0001233 abnormal epidermis suprabasal layer morphology 1.001E-2 4.014E-2
2.131E-1
1.000E0
 1 26
28 MP:0000468 abnormal esophageal epithelium morphology 1.039E-2 4.014E-2
2.131E-1
1.000E0
 1 27
29 MP:0006267 abnormal intercalated disk morphology 1.077E-2 4.014E-2
2.131E-1
1.000E0
 1 28
30 MP:0009406 decreased skeletal muscle fiber number 1.116E-2 4.014E-2
2.131E-1
1.000E0
 1 29
31 MP:0000764 abnormal tongue epithelium morphology 1.116E-2 4.014E-2
2.131E-1
1.000E0
 1 29
32 MP:0008415 abnormal neurite morphology 1.137E-2 4.014E-2
2.131E-1
1.000E0
 2 465
33 MP:0003630 abnormal urothelium morphology 1.269E-2 4.345E-2
2.307E-1
1.000E0
 1 33
34 MP:0009413 skeletal muscle fiber atrophy 1.345E-2 4.467E-2
2.372E-1
1.000E0
 1 35
35 MP:0010957 abnormal aerobic respiration 1.384E-2 4.467E-2
2.372E-1
1.000E0
 1 36
36 MP:0009399 increased skeletal muscle fiber size 1.498E-2 4.692E-2
2.491E-1
1.000E0
 1 39
37 MP:0000579 abnormal nail morphology 1.536E-2 4.692E-2
2.491E-1
1.000E0
 1 40
38 MP:0001849 ear inflammation 1.689E-2 4.772E-2
2.533E-1
1.000E0
 1 44
39 MP:0011708 decreased fibroblast cell migration 1.689E-2 4.772E-2
2.533E-1
1.000E0
 1 44
40 MP:0003852 skeletal muscle necrosis 1.689E-2 4.772E-2
2.533E-1
1.000E0
 1 44
41 MP:0008883 abnormal enterocyte proliferation 1.803E-2 4.955E-2
2.630E-1
1.000E0
 1 47
42 MP:0009402 decreased skeletal muscle fiber diameter 1.842E-2 4.955E-2
2.630E-1
1.000E0
 1 48
Show 37 more annotations

6: Domain [Display Chart] 6 input genes in category / 70 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001101 Plectin repeat InterPro 1.023E-13 2.386E-12 1.153E-11 7.159E-12 4 7
2 PF00681 Plectin Pfam 1.023E-13 2.386E-12 1.153E-11 7.159E-12 4 7
3 SM00250 PLEC SMART 1.023E-13 2.386E-12 1.153E-11 7.159E-12 4 7
4 IPR002017 Spectrin repeat InterPro 6.928E-11 1.212E-9 5.859E-9 4.849E-9 4 29
5 IPR018159 Spectrin/alpha-actinin InterPro 1.049E-10 1.223E-9 5.912E-9 7.340E-9 4 32
6 SM00150 SPEC SMART 1.049E-10 1.223E-9 5.912E-9 7.340E-9 4 32
7 3.90.1290.10 - Gene3D 3.649E-10 3.649E-9 1.763E-8 2.554E-8 3 6
8 PS00020 ACTININ 2 PROSITE 2.156E-5 1.509E-4 7.294E-4 1.509E-3 2 23
9 PS00019 ACTININ 1 PROSITE 2.156E-5 1.509E-4 7.294E-4 1.509E-3 2 23
10 IPR001589 Actinin actin-bd CS InterPro 2.156E-5 1.509E-4 7.294E-4 1.509E-3 2 23
11 SM00033 CH SMART 1.762E-4 1.095E-3 5.294E-3 1.233E-2 2 65
12 PF00307 CH Pfam 2.044E-4 1.095E-3 5.294E-3 1.431E-2 2 70
13 1.10.418.10 - Gene3D 2.103E-4 1.095E-3 5.294E-3 1.472E-2 2 71
14 PS50021 CH PROSITE 2.224E-4 1.095E-3 5.294E-3 1.557E-2 2 73
15 IPR001715 CH-domain InterPro 2.347E-4 1.095E-3 5.294E-3 1.643E-2 2 75
16 IPR029926 Dystonin InterPro 3.203E-4 1.245E-3 6.019E-3 2.242E-2 1 1
17 IPR030269 Plectin InterPro 3.203E-4 1.245E-3 6.019E-3 2.242E-2 1 1
18 IPR012013 Integrin bsu-4 InterPro 3.203E-4 1.245E-3 6.019E-3 2.242E-2 1 1
19 IPR030460 Envoplakin InterPro 6.404E-4 2.135E-3 1.032E-2 4.483E-2 1 2
20 IPR005326 S10 plectin N InterPro 6.404E-4 2.135E-3 1.032E-2 4.483E-2 1 2
21 PF03501 S10 plectin Pfam 6.404E-4 2.135E-3 1.032E-2 4.483E-2 1 2
22 PF02187 GAS2 Pfam 1.920E-3 5.168E-3 2.498E-2
1.344E-1
 1 6
23 PS51460 GAR PROSITE 1.920E-3 5.168E-3 2.498E-2
1.344E-1
 1 6
24 3.30.920.20 - Gene3D 1.920E-3 5.168E-3 2.498E-2
1.344E-1
 1 6
25 IPR003108 GAS dom InterPro 1.920E-3 5.168E-3 2.498E-2
1.344E-1
 1 6
26 SM00243 GAS2 SMART 1.920E-3 5.168E-3 2.498E-2
1.344E-1
 1 6
27 PF07965 Integrin B tail Pfam 2.240E-3 5.168E-3 2.498E-2
1.568E-1
 1 7
28 IPR012896 Integrin bsu tail InterPro 2.240E-3 5.168E-3 2.498E-2
1.568E-1
 1 7
29 SM01242 Integrin B tail SMART 2.240E-3 5.168E-3 2.498E-2
1.568E-1
 1 7
30 IPR002369 Integrin bsu VWA InterPro 2.560E-3 5.168E-3 2.498E-2
1.792E-1
 1 8
31 SM00187 INB SMART 2.560E-3 5.168E-3 2.498E-2
1.792E-1
 1 8
32 SM00237 Calx beta SMART 2.560E-3 5.168E-3 2.498E-2
1.792E-1
 1 8
33 PF00362 Integrin beta Pfam 2.560E-3 5.168E-3 2.498E-2
1.792E-1
 1 8
34 PF03160 Calx-beta Pfam 2.879E-3 5.168E-3 2.498E-2
2.015E-1
 1 9
35 PS00243 INTEGRIN BETA PROSITE 2.879E-3 5.168E-3 2.498E-2
2.015E-1
 1 9
36 PF17205 PSI integrin Pfam 2.879E-3 5.168E-3 2.498E-2
2.015E-1
 1 9
37 IPR033760 Integin beta N InterPro 2.879E-3 5.168E-3 2.498E-2
2.015E-1
 1 9
38 IPR003644 Calx beta InterPro 2.879E-3 5.168E-3 2.498E-2
2.015E-1
 1 9
39 IPR015812 Integrin bsu InterPro 2.879E-3 5.168E-3 2.498E-2
2.015E-1
 1 9
40 PF00435 Spectrin Pfam 7.344E-3 1.285E-2
6.211E-2
5.141E-1
 1 23
41 IPR016201 PSI InterPro 1.401E-2 2.392E-2
1.156E-1
9.807E-1
 1 44
42 SM00423 PSI SMART 1.464E-2 2.441E-2
1.180E-1
1.000E0
 1 46
43 PF07974 EGF 2 Pfam 1.906E-2 3.033E-2
1.466E-1
1.000E0
 1 60
44 IPR013111 EGF extracell InterPro 1.906E-2 3.033E-2
1.466E-1
1.000E0
 1 60
45 3.40.50.410 - Gene3D 2.347E-2 3.651E-2
1.764E-1
1.000E0
 1 74
46 PS50234 VWFA PROSITE 2.598E-2 3.769E-2
1.821E-1
1.000E0
 1 82
47 SM00327 VWA SMART 2.661E-2 3.769E-2
1.821E-1
1.000E0
 1 84
48 IPR008160 Collagen InterPro 2.692E-2 3.769E-2
1.821E-1
1.000E0
 1 85
49 PF01391 Collagen Pfam 2.692E-2 3.769E-2
1.821E-1
1.000E0
 1 85
50 PF13499 EF-hand 7 Pfam 2.692E-2 3.769E-2
1.821E-1
1.000E0
 1 85
Show 45 more annotations

7: Pathway [Display Chart] 6 input genes in category / 36 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270240 Type I hemidesmosome assembly BioSystems: REACTOME 4.943E-12 1.779E-10 7.428E-10 1.779E-10 4 11
2 1270232 Cell junction organization BioSystems: REACTOME 3.620E-8 5.192E-7 2.168E-6 1.303E-6 4 89
3 1270245 Collagen formation BioSystems: REACTOME 4.327E-8 5.192E-7 2.168E-6 1.558E-6 4 93
4 1270231 Cell-Cell communication BioSystems: REACTOME 1.893E-7 1.704E-6 7.112E-6 6.815E-6 4 134
5 1270247 Assembly of collagen fibrils and other multimeric structures BioSystems: REACTOME 2.107E-6 1.517E-5 6.332E-5 7.584E-5 3 60
6 1270244 Extracellular matrix organization BioSystems: REACTOME 4.647E-6 2.788E-5 1.164E-4 1.673E-4 4 298
7 138008 a6b1 and a6b4 Integrin signaling BioSystems: Pathway Interaction Database 8.945E-5 4.600E-4 1.920E-3 3.220E-3 2 31
8 1457791 Formation of the cornified envelope BioSystems: REACTOME 4.739E-4 2.133E-3 8.903E-3 1.706E-2 2 71
9 P00034 Integrin signalling pathway PantherDB 2.590E-3 1.036E-2 4.324E-2
9.322E-2
 2 167
10 1457790 Keratinization BioSystems: REACTOME 4.215E-3 1.517E-2
6.334E-2
1.517E-1
 2 214
11 1470922 Butyrophilin (BTN) family interactions BioSystems: REACTOME 5.770E-3 1.875E-2
7.827E-2
2.077E-1
 1 12
12 1270289 Caspase-mediated cleavage of cytoskeletal proteins BioSystems: REACTOME 6.250E-3 1.875E-2
7.827E-2
2.250E-1
 1 13
13 1270255 Syndecan interactions BioSystems: REACTOME 1.008E-2 2.791E-2
1.165E-1
3.629E-1
 1 21
14 1270253 Laminin interactions BioSystems: REACTOME 1.199E-2 3.083E-2
1.287E-1
4.316E-1
 1 25
15 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 1.628E-2 3.847E-2
1.606E-1
5.860E-1
 1 34
16 PW:0000286 integrin signaling Pathway Ontology 1.818E-2 3.847E-2
1.606E-1
6.544E-1
 1 38
17 1270288 Apoptotic cleavage of cellular proteins BioSystems: REACTOME 1.865E-2 3.847E-2
1.606E-1
6.715E-1
 1 39
18 1270259 Collagen degradation BioSystems: REACTOME 1.960E-2 3.847E-2
1.606E-1
7.056E-1
 1 41
19 M3005 Genes encoding collagen proteins MSigDB C2 BIOCARTA (v6.0) 2.102E-2 3.847E-2
1.606E-1
7.568E-1
 1 44
20 1270254 Non-integrin membrane-ECM interactions BioSystems: REACTOME 2.197E-2 3.847E-2
1.606E-1
7.909E-1
 1 46
21 1470926 Collagen chain trimerization BioSystems: REACTOME 2.244E-2 3.847E-2
1.606E-1
8.079E-1
 1 47
22 1270287 Apoptotic execution phase BioSystems: REACTOME 2.528E-2 4.136E-2
1.727E-1
9.100E-1
 1 53
23 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 2.905E-2 4.546E-2
1.898E-1
1.000E0
 1 61
24 1270246 Collagen biosynthesis and modifying enzymes BioSystems: REACTOME 3.327E-2 4.926E-2
2.056E-1
1.000E0
 1 70
25 117293 Arrhythmogenic right ventricular cardiomyopathy (ARVC) BioSystems: KEGG 3.421E-2 4.926E-2
2.056E-1
1.000E0
 1 72
Show 20 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 778 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14668477 Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes. Pubmed 1.692E-16 1.316E-13 9.524E-13 1.316E-13 4 4
2 10637308 The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome. Pubmed 5.922E-15 2.304E-12 1.667E-11 4.607E-12 4 7
3 12482924 Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. Pubmed 2.132E-14 5.528E-12 3.999E-11 1.658E-11 4 9
4 16757171 Current insights into the formation and breakdown of hemidesmosomes. Pubmed 5.582E-14 7.239E-12 5.237E-11 4.343E-11 4 11
5 12802069 Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus. Pubmed 5.582E-14 7.239E-12 5.237E-11 4.343E-11 4 11
6 10811835 The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. Pubmed 5.582E-14 7.239E-12 5.237E-11 4.343E-11 4 11
7 20301304 Junctional Epidermolysis Bullosa Pubmed 7.538E-11 8.377E-9 6.061E-8 5.864E-8 3 7
8 17920818 Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
9 12432088 Interaction of periplakin and envoplakin with intermediate filaments. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
10 15033990 Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
11 15817481 Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
12 24676719 Circulating anti-BP180 NC16a and anti-BP230 autoantibodies in patients with genital lichen sclerosus do not correlate with disease activity and pruritus. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
13 17662978 Cytolinker cross-talk: periplakin N-terminus interacts with plectin to regulate keratin organisation and epithelial migration. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
14 11062259 Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
15 24843010 Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
16 18820940 Detection of anti-envoplakin and anti-periplakin autoantibodies by ELISA in patients with paraneoplastic pemphigus. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
17 26763429 Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
18 11328943 Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations. Pubmed 2.057E-8 8.889E-7 6.431E-6 1.600E-5 2 2
19 9412476 Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
20 9521878 cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
21 19932097 BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
22 19419971 Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
23 19242489 Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
24 2045679 Bullous pemphigoid antigen: cDNA cloning, cellular expression, and evidence for polymorphism of the human gene. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
25 11854008 Plakins: a family of versatile cytolinker proteins. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
26 20301336 Epidermolysis Bullosa with Pyloric Atresia Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
27 9500991 Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes. Pubmed 6.170E-8 1.778E-6 1.286E-5 4.800E-5 2 3
28 11375975 The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. Pubmed 1.234E-7 3.097E-6 2.240E-5 9.599E-5 2 4
29 19403692 BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities. Pubmed 1.234E-7 3.097E-6 2.240E-5 9.599E-5 2 4
30 9660880 Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. Pubmed 1.234E-7 3.097E-6 2.240E-5 9.599E-5 2 4
31 25703379 Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes. Pubmed 1.234E-7 3.097E-6 2.240E-5 9.599E-5 2 4
32 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 2.045E-7 4.973E-6 3.598E-5 1.591E-4 4 416
33 12366696 Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. Pubmed 3.084E-7 7.271E-6 5.260E-5 2.399E-4 2 6
34 20936779 A human MAP kinase interactome. Pubmed 3.807E-7 8.711E-6 6.302E-5 2.962E-4 4 486
35 20301481 Dystrophic Epidermolysis Bullosa Pubmed 4.318E-7 9.597E-6 6.943E-5 3.359E-4 2 7
36 9670011 Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. Pubmed 7.400E-7 1.556E-5 1.126E-4 5.758E-4 2 9
37 15500642 Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases. Pubmed 7.400E-7 1.556E-5 1.126E-4 5.758E-4 2 9
38 22962592 Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. Pubmed 1.356E-6 2.706E-5 1.958E-4 1.055E-3 2 12
39 28595999 p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. Pubmed 1.356E-6 2.706E-5 1.958E-4 1.055E-3 2 12
40 18166659 Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. Pubmed 2.158E-6 4.196E-5 3.036E-4 1.679E-3 2 15
41 15951569 Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Pubmed 5.678E-5 4.143E-4 2.997E-3 4.418E-2 2 75
42 25670202 Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Pubmed 7.129E-5 4.143E-4 2.997E-3
5.546E-2
 2 84
43 26561776 Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Pubmed 9.710E-5 4.143E-4 2.997E-3
7.554E-2
 2 98
44 22558309 Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. Pubmed 1.246E-4 4.143E-4 2.997E-3
9.694E-2
 2 111
45 24330315 Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen. Pubmed 1.571E-4 4.143E-4 2.997E-3
1.222E-1
 1 1
46 14987253 Genetic variation in COL17A1 and the development of bullous pemphigoid. Pubmed 1.571E-4 4.143E-4 2.997E-3
1.222E-1
 1 1
47 9207246 The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences. Pubmed 1.571E-4 4.143E-4 2.997E-3
1.222E-1
 1 1
48 21638337 Changes in dynorphin immunoreactivity but unaltered density of enkephalin immunoreactive neurons in basal ganglia nuclei of genetically dystonic hamsters. Pubmed 1.571E-4 4.143E-4 2.997E-3
1.222E-1
 1 1
49 19340010 Glycine substitution mutations cause intracellular accumulation of collagen XVII and affect its post-translational modifications. Pubmed 1.571E-4 4.143E-4 2.997E-3
1.222E-1
 1 1
50 2645368 Definition of bullous pemphigoid antibody binding to intracellular and extracellular antigen associated with hemidesmosomes. Pubmed 1.571E-4 4.143E-4 2.997E-3
1.222E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 266 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:COL17A1 COL17A1 interactions 1.809E-15 4.812E-13 2.965E-12 4.812E-13 5 16
2 int:ITGB4 ITGB4 interactions 7.737E-10 1.029E-7 6.341E-7 2.058E-7 4 49
3 int:ITGA6 ITGA6 interactions 4.751E-7 3.749E-5 2.311E-4 1.264E-4 3 52
4 int:PPL PPL interactions 5.638E-7 3.749E-5 2.311E-4 1.500E-4 3 55
5 int:DST DST interactions 8.943E-7 4.758E-5 2.932E-4 2.379E-4 3 64
6 int:DDX19B DDX19B interactions 5.405E-6 2.396E-4 1.477E-3 1.438E-3 3 116
7 int:PLEC PLEC interactions 1.057E-5 4.017E-4 2.476E-3 2.812E-3 3 145
8 int:UGT1A10 UGT1A10 interactions 2.005E-5 6.665E-4 4.108E-3 5.332E-3 2 21
9 int:SUSD3 SUSD3 interactions 2.414E-5 7.136E-4 4.397E-3 6.422E-3 2 23
10 int:RBM24 RBM24 interactions 3.348E-5 8.904E-4 5.487E-3 8.904E-3 2 27
11 int:CCNYL1 CCNYL1 interactions 6.693E-5 1.619E-3 9.975E-3 1.780E-2 2 38
12 int:EVPL EVPL interactions 7.424E-5 1.646E-3 1.014E-2 1.975E-2 2 40
13 int:DROSHA DROSHA interactions 9.416E-5 1.927E-3 1.187E-2 2.505E-2 2 45
14 int:FRMD1 FRMD1 interactions 1.028E-4 1.953E-3 1.204E-2 2.734E-2 2 47
15 int:VIM VIM interactions 1.177E-4 2.087E-3 1.286E-2 3.130E-2 3 325
16 int:ZSCAN20 ZSCAN20 interactions 1.569E-4 2.609E-3 1.608E-2 4.174E-2 2 58
17 int:KRT14 KRT14 interactions 1.794E-4 2.807E-3 1.730E-2 4.772E-2 2 62
18 int:FCF1 FCF1 interactions 1.972E-4 2.915E-3 1.796E-2
5.247E-2
 2 65
19 int:ACAD9 ACAD9 interactions 2.558E-4 3.581E-3 2.207E-2
6.804E-2
 2 74
20 int:KRT5 KRT5 interactions 3.536E-4 4.479E-3 2.760E-2
9.405E-2
 2 87
21 int:PLEKHA5 PLEKHA5 interactions 3.536E-4 4.479E-3 2.760E-2
9.405E-2
 2 87
22 int:CDK15 CDK15 interactions 5.049E-4 6.105E-3 3.762E-2
1.343E-1
 2 104
23 int:TBC1D22B TBC1D22B interactions 5.646E-4 6.372E-3 3.927E-2
1.502E-1
 2 110
24 int:ERBIN ERBIN interactions 5.749E-4 6.372E-3 3.927E-2
1.529E-1
 2 111
25 int:SOCS6 SOCS6 interactions 6.494E-4 6.909E-3 4.258E-2
1.727E-1
 2 118
26 int:PSORS1C2 PSORS1C2 interactions 6.778E-4 6.934E-3 4.273E-2
1.803E-1
 1 2
27 int:DSP DSP interactions 7.053E-4 6.948E-3 4.282E-2
1.876E-1
 2 123
28 int:SKI SKI interactions 7.634E-4 7.253E-3 4.470E-2
2.031E-1
 2 128
29 int:SMAD9 SMAD9 interactions 8.738E-4 8.015E-3 4.939E-2
2.324E-1
 2 137
30 int:ANLN ANLN interactions 1.032E-3 9.154E-3
5.641E-2
2.746E-1
 2 149
31 int:SYNPO SYNPO interactions 1.204E-3 1.033E-2
6.365E-2
3.202E-1
 2 161
32 int:CLCA1 CLCA1 interactions 1.355E-3 1.098E-2
6.769E-2
3.605E-1
 1 4
33 int:MAPRE1 MAPRE1 interactions 1.404E-3 1.098E-2
6.769E-2
3.734E-1
 2 174
34 int:MYO18A MYO18A interactions 1.404E-3 1.098E-2
6.769E-2
3.734E-1
 2 174
35 int:MYO19 MYO19 interactions 1.469E-3 1.116E-2
6.878E-2
3.906E-1
 2 178
36 int:CLCA2 CLCA2 interactions 1.694E-3 1.218E-2
7.504E-2
4.505E-1
 1 5
37 int:ENPP2 ENPP2 interactions 1.694E-3 1.218E-2
7.504E-2
4.505E-1
 1 5
38 int:GAN GAN interactions 2.017E-3 1.386E-2
8.541E-2
5.365E-1
 2 209
39 int:PI3 PI3 interactions 2.032E-3 1.386E-2
8.541E-2
5.405E-1
 1 6
40 int:JUP JUP interactions 2.094E-3 1.392E-2
8.580E-2
5.569E-1
 2 213
41 int:MUC5AC MUC5AC interactions 3.047E-3 1.930E-2
1.189E-1
8.105E-1
 1 9
42 int:KAZN KAZN interactions 3.047E-3 1.930E-2
1.189E-1
8.105E-1
 1 9
43 int:LIMA1 LIMA1 interactions 3.242E-3 1.945E-2
1.198E-1
8.624E-1
 2 266
44 int:CAPZA2 CAPZA2 interactions 3.314E-3 1.945E-2
1.198E-1
8.816E-1
 2 269
45 int:BFSP1 BFSP1 interactions 3.385E-3 1.945E-2
1.198E-1
9.004E-1
 1 10
46 int:ALOX12 ALOX12 interactions 3.385E-3 1.945E-2
1.198E-1
9.004E-1
 1 10
47 int:SPDL1 SPDL1 interactions 3.436E-3 1.945E-2
1.198E-1
9.140E-1
 2 274
48 int:LAD1 LAD1 interactions 3.723E-3 2.002E-2
1.234E-1
9.903E-1
 1 11
49 int:SPRR3 SPRR3 interactions 3.723E-3 2.002E-2
1.234E-1
9.903E-1
 1 11
50 int:PPP1CB PPP1CB interactions 3.763E-3 2.002E-2
1.234E-1
1.000E0
 2 287
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q25 17q25 1.845E-5 9.226E-5 2.107E-4 9.226E-5 2 39
2 10q24.3 10q24.3 1.038E-3 2.596E-3 5.927E-3 5.191E-3 1 6
3 8q24 8q24 5.010E-3 7.124E-3 1.627E-2 2.505E-2 1 29
4 6p12.1 6p12.1 5.699E-3 7.124E-3 1.627E-2 2.850E-2 1 33
5 16p13.3 16p13.3 4.351E-2 4.351E-2
9.934E-2
2.175E-1
 1 256

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 71 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$LYF1 01 V$LYF1 01 1.119E-4 7.946E-3 3.851E-2 7.946E-3 3 222

12: Gene Family [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 939 Plakins genenames.org 2.300E-13 1.380E-12 3.381E-12 1.380E-12 4 8
2 1159 Integrin beta subunits genenames.org 2.965E-3 8.894E-3 2.179E-2 1.779E-2 1 9
3 490 Collagens genenames.org 1.508E-2 3.015E-2
7.387E-2
9.046E-2
 1 46

13: Coexpression [Display Chart] 6 input genes in category / 700 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10702 Genes down-regulated in metastases from malignant melanoma compared to the primary tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.863E-10 6.904E-7 4.922E-6 6.904E-7 5 258
2 M8417 Metastatic propensity markers of head and neck squamous cell carcinoma (HNSCC): down-regulated in metastatic vs non-metastatic tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.079E-9 7.278E-7 5.189E-6 1.456E-6 4 81
3 15988020-Table1 Human StemCell Osada05 129genes GeneSigDB 1.208E-8 2.818E-6 2.009E-5 8.453E-6 4 125
4 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.140E-7 8.995E-5 6.413E-4 3.598E-4 4 318
5 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.320E-6 3.248E-4 2.316E-3 1.624E-3 4 464
6 M17428 Genes up-regulated in leukemic stem cells (LSC), defined as CD34+CD38- [GeneID=947;952] cells from AML (acute myeloid leukemia patients) compared to the CD34+CD38+ cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.667E-6 4.188E-4 2.986E-3 2.567E-3 3 133
7 20713713-TableS1a Human Breast Taube10 160genes EMTsignature down GeneSigDB 4.188E-6 4.188E-4 2.986E-3 2.932E-3 3 139
8 14676830-Table6 Human HeadandNeck Cromer04 18genes GeneSigDB 8.559E-6 7.489E-4 5.339E-3 5.991E-3 2 18
9 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v6.0) 1.140E-5 8.480E-4 6.045E-3 7.977E-3 3 194
10 M14134 Genes down-regulated in ductal carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.211E-5 8.480E-4 6.045E-3 8.480E-3 3 198
11 17389037-Tab2 Human Breast Turashvili07 326genes GeneSigDB 1.997E-5 1.271E-3 9.061E-3 1.398E-2 3 234
12 M292 Genes up-regulated in hypertrophic scar fibroblasts in response to IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.430E-5 1.418E-3 1.011E-2 1.701E-2 2 30
13 M16114 Genes down-regulated in HFK cells (primary keratinocytes) in response to UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.949E-5 1.588E-3 1.132E-2 2.064E-2 2 33
14 M11504 Genes down-regulated in prostate cancer vs benign prostate tissue, based on a meta-analysis of five gene expression profiling studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.352E-5 2.176E-3 1.551E-2 3.047E-2 2 40
15 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.097E-5 3.042E-3 2.169E-2 4.968E-2 3 358
16 M6225 Genes up-regulated in Barrett's esophagus compared to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.105E-5 3.042E-3 2.169E-2 4.974E-2 2 51
17 12874079-Table3a Human HeadandNeck Sok03 57genes GeneSigDB 7.389E-5 3.042E-3 2.169E-2
5.172E-2
 2 52
18 19204204-SupplementaryTable2 Human Breast Parker09 412genes IntrinsicGenes Perou2000 GeneSigDB 8.276E-5 3.160E-3 2.253E-2
5.794E-2
 3 377
19 19395651-TableS2b Mouse StemCell Bonuccelli09 63genes GeneSigDB 8.577E-5 3.160E-3 2.253E-2
6.004E-2
 2 56
20 M2494 Genes down-regulated in primary LEC cells (lymphatic endothelum) upon overexpression of MIR31 [GeneID=407035]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.109E-4 3.880E-3 2.766E-2
7.760E-2
 3 416
21 M16774 Genes down-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.193E-4 3.978E-3 2.836E-2
8.353E-2
 2 66
22 M2948 Cluster 8: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.421E-4 4.521E-3 3.223E-2
9.947E-2
 2 72
23 19395651-TableS1a Mouse StemCell Bonuccelli09 119genes GeneSigDB 1.755E-4 5.220E-3 3.721E-2
1.229E-1
 2 80
24 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.790E-4 5.220E-3 3.721E-2
1.253E-1
 3 489
25 16417408-Figure4 Human Breast Chi06 123genes GeneSigDB 3.379E-4 9.401E-3
6.702E-2
2.365E-1
 2 111
26 14982484-Table3 Human Intestine Vozenin-Brotons04 119genes GeneSigDB 3.501E-4 9.401E-3
6.702E-2
2.451E-1
 2 113
27 19328798-SuppTable2 Human Colon Fritzmann09 123genes GeneSigDB 3.626E-4 9.401E-3
6.702E-2
2.538E-1
 2 115
28 M11857 Genes down-regulated in HCT8/S11 cells (colon cancer) engineered to stably express NTN1 [GeneID=1630] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.827E-4 1.696E-2
1.209E-1
4.779E-1
 2 158
29 M5649 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMC from patients with acute S. pneumoniae infection. MSigDB C7: Immunologic Signatures (v6.0) 7.804E-4 1.696E-2
1.209E-1
5.463E-1
 2 169
30 15833844-Table1S Human Esophagus Kimchi05 213genes GeneSigDB 8.082E-4 1.696E-2
1.209E-1
5.657E-1
 2 172
31 M5658 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. pneumoniae infection. MSigDB C7: Immunologic Signatures (v6.0) 8.459E-4 1.696E-2
1.209E-1
5.921E-1
 2 176
32 M12621 Genes up-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.041E-4 1.696E-2
1.209E-1
6.329E-1
 2 182
33 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.239E-4 1.696E-2
1.209E-1
6.468E-1
 2 184
34 M2822 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL2 [Gene ID=3558]. MSigDB C6: Oncogenic Signatures (v6.0) 9.950E-4 1.696E-2
1.209E-1
6.965E-1
 2 191
35 M2673 Genes down-regulated in HUVEC cells (endothelium) by treatment with PIGF [Gene ID=5281]. MSigDB C6: Oncogenic Signatures (v6.0) 1.016E-3 1.696E-2
1.209E-1
7.110E-1
 2 193
36 M2676 Genes up-regulated in HUVEC cells (endothelium) by treatment with VEGFA [Gene ID=7422]. MSigDB C6: Oncogenic Signatures (v6.0) 1.037E-3 1.696E-2
1.209E-1
7.257E-1
 2 195
37 M4982 Genes up-regulated in comparison of B cells from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.209E-1
7.555E-1
 2 199
38 M6798 Genes down-regulated in lymph node B lymphocytes with influenza infection: wildtype versus IFNAR1 [GeneID=2454] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.696E-2
1.209E-1
7.555E-1
 2 199
39 M5769 Genes up-regulated in IL7R [GeneID=3575] low effector CD8 T cells versus IL7R [GeneID=3575] high effector CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
40 M5915 Genes encoding components of apical junction complex. MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
41 M8220 Genes down-regulated in Pmel-1 CD8 T cells: naïve versus primed with cognate antigen (gp100) and IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
42 M8203 Genes up-regulated in wildtype cytotoxic T lymphocytes versus those overexpressing phosphorylation deficient form of HDAC7 [GeneID=51564]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
43 M5132 Genes down-regulated in comparison of ex vivo CD8 dendritic cells versus cultured CD8 DCs. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
44 M6390 Genes up-regulated in plasma cells versus germinal center B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
45 M5357 Genes up-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 12 h versus PMN treated with F. tularensis vaccine at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.696E-2
1.209E-1
7.630E-1
 2 200
46 18394172-S3GeneList Mouse Breast Wright08 339genes GeneSigDB 1.258E-3 1.914E-2
1.365E-1
8.806E-1
 2 215
47 16877703-TableS2 Human Lung Coldren06 305genes GeneSigDB 1.305E-3 1.943E-2
1.385E-1
9.133E-1
 2 219
48 M6744 Genes down-regulated in NSCLC (non-small cell lung carcinoma) cell lines resistant to gefitinib [PubChem=123631] compared to the sensitive ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.425E-3 2.078E-2
1.482E-1
9.976E-1
 2 229
49 M12369 Genes down-regulated in metastatic vs non-metastatic HNSCC (head and neck squamous cell carcinoma) samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.845E-3 2.636E-2
1.880E-1
1.000E0
 2 261
50 M2089 Genes showing significantly elevated somatic mutation frequencies in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.332E-3 3.265E-2
2.327E-1
1.000E0
 1 9
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 432 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.834E-7 7.924E-5 5.267E-4 7.924E-5 4 232
2 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.273E-7 1.355E-4 9.005E-4 2.710E-4 3 70
3 gudmap developingLowerUrinaryTract P1 bladder B 1000 k4 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.396E-6 2.048E-4 1.361E-3 1.035E-3 3 109
4 gudmap developingLowerUrinaryTract adult ureter 100 k4 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.830E-6 2.048E-4 1.361E-3 1.223E-3 2 10
5 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 100 k4 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.830E-6 2.048E-4 1.361E-3 1.223E-3 2 10
6 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 100 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.459E-6 2.048E-4 1.361E-3 1.494E-3 2 11
7 PCBC ctl BronchioEpithel 500 Progenitor-Cell-Biology-Consortium reference BronchioEpithel top-relative-expression-ranked 500 PCBC 3.903E-6 2.048E-4 1.361E-3 1.686E-3 4 499
8 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 100 k5 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.150E-6 2.048E-4 1.361E-3 1.793E-3 2 12
9 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 1000 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.266E-6 2.048E-4 1.361E-3 1.843E-3 3 132
10 gudmap developingLowerUrinaryTract P1 bladder J 1000 k5 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.894E-6 3.410E-4 2.267E-3 3.410E-3 3 162
11 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 1000 k4 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.805E-6 3.458E-4 2.298E-3 3.804E-3 3 168
12 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.074E-5 3.799E-4 2.525E-3 4.641E-3 2 19
13 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 100 k3 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.194E-5 3.799E-4 2.525E-3 5.157E-3 2 20
14 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin Tabula Muris Consortium 1.234E-5 3.799E-4 2.525E-3 5.329E-3 3 188
15 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 200 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.319E-5 3.799E-4 2.525E-3 5.699E-3 2 21
16 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 200 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.589E-5 4.290E-4 2.851E-3 6.864E-3 2 23
17 gudmap developingLowerUrinaryTract adult ureter 1000 k3 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.718E-5 4.367E-4 2.902E-3 7.423E-3 3 210
18 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 200 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.884E-5 4.520E-4 3.005E-3 8.137E-3 2 25
19 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k3 200 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.312E-5 7.153E-4 4.755E-3 1.431E-2 2 33
20 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 k5 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.312E-5 7.153E-4 4.755E-3 1.431E-2 2 33
21 gudmap developingLowerUrinaryTract e15.5 Urothelium 1000 k5 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.102E-5 8.438E-4 5.608E-3 1.772E-2 3 281
22 gudmap developingLowerUrinaryTract e14.5 urethra 200 k4 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.644E-5 8.723E-4 5.798E-3 2.006E-2 2 39
23 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k5 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.644E-5 8.723E-4 5.798E-3 2.006E-2 2 39
24 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.062E-5 1.271E-3 8.449E-3 3.051E-2 2 48
25 gudmap developingLowerUrinaryTract adult ureter 500 DevelopingLowerUrinaryTract adult ureter emap-29479 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.603E-5 1.651E-3 1.097E-2 4.149E-2 3 374
26 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 1000 k4 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.034E-4 1.651E-3 1.097E-2 4.465E-2 2 58
27 gudmap developingLowerUrinaryTract P1 bladder B 500 k3 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.070E-4 1.651E-3 1.097E-2 4.621E-2 2 59
28 gudmap developingLowerUrinaryTract adult ureter 200 k1 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.070E-4 1.651E-3 1.097E-2 4.621E-2 2 59
29 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k1 500 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.144E-4 1.670E-3 1.110E-2 4.942E-2 2 61
30 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.190E-4 1.670E-3 1.110E-2
5.140E-2
 3 402
31 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 Gudmap RNAseq 1.199E-4 1.670E-3 1.110E-2
5.178E-2
 3 403
32 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K2 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K2 Gudmap RNAseq 1.423E-4 1.921E-3 1.277E-2
6.146E-2
 3 427
33 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 k5 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.640E-4 2.081E-3 1.383E-2
7.086E-2
 2 73
34 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 1.684E-4 2.081E-3 1.383E-2
7.274E-2
 3 452
35 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 1000 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.686E-4 2.081E-3 1.383E-2
7.282E-2
 2 74
36 skin skin Human Protein Atlas 1.751E-4 2.101E-3 1.396E-2
7.563E-2
 3 458
37 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 100 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.873E-4 2.129E-3 1.415E-2
8.092E-2
 2 78
38 gudmap developingLowerUrinaryTract adult ureter 100 DevelopingLowerUrinaryTract adult ureter emap-29479 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.873E-4 2.129E-3 1.415E-2
8.092E-2
 2 78
39 gudmap developingLowerUrinaryTract e14.5 urethra 500 k1 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.922E-4 2.129E-3 1.415E-2
8.302E-2
 2 79
40 BM Top 100 - vulva BM Top 100 - vulva Body Map 2.071E-4 2.236E-3 1.486E-2
8.945E-2
 2 82
41 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 100 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.225E-4 2.307E-3 1.533E-2
9.612E-2
 2 85
42 PCBC ctl SmallAirwayEpithel 500 Progenitor-Cell-Biology-Consortium reference SmallAirwayEpithel top-relative-expression-ranked 500 PCBC 2.242E-4 2.307E-3 1.533E-2
9.688E-2
 3 498
43 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 100 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.385E-4 2.396E-3 1.593E-2
1.030E-1
 2 88
44 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3/C1ql2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3/C1ql2 BrainMap 2.495E-4 2.449E-3 1.628E-2
1.078E-1
 2 90
45 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 100 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.607E-4 2.502E-3 1.663E-2
1.126E-1
 2 92
46 PCBC ctl BronchioEpithel 100 Progenitor-Cell-Biology-Consortium reference BronchioEpithel top-relative-expression-ranked 100 PCBC 3.079E-4 2.892E-3 1.922E-2
1.330E-1
 2 100
47 gudmap developingLowerUrinaryTract e14.5 urethra 1000 k5 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.658E-4 3.292E-3 2.188E-2
1.580E-1
 2 109
48 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k5 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.658E-4 3.292E-3 2.188E-2
1.580E-1
 2 109
49 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/4 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/4 TCGA-Prostate 4.141E-4 3.651E-3 2.427E-2
1.789E-1
 2 116
50 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k1 1000 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.505E-4 3.892E-3 2.587E-2
1.946E-1
 2 121
Show 45 more annotations

15: Computational [Display Chart] 6 input genes in category / 29 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M18170 MODULE 154 Intermediate filaments. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.887E-6 9.267E-5 3.671E-4 2.287E-4 3 75
2 M4992 MODULE 297 Genes in the cancer module 297. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.586E-6 9.267E-5 3.671E-4 2.780E-4 3 80
3 M9185 MODULE 357 Intermediate filaments and keratins. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.586E-6 9.267E-5 3.671E-4 2.780E-4 3 80
4 M2266 GNF2 SPRR1B Neighborhood of SPRR1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.880E-5 6.438E-4 2.551E-3 2.575E-3 2 25
5 M18929 MODULE 12 Spinal cord (neuro-development) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.442E-4 4.896E-3 1.940E-2 2.448E-2 3 360
6 M9982 MODULE 2 DRG (dorsal root ganglia) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.019E-3 4.927E-3 1.952E-2 2.956E-2 3 384
7 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.287E-3 5.334E-3 2.113E-2 3.734E-2 3 416
8 M3463 MODULE 44 Thymus genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.455E-2 4.418E-2
1.750E-1
4.220E-1
 2 327
9 M17677 GNF2 CDH3 Neighborhood of CDH3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.604E-2 4.418E-2
1.750E-1
4.650E-1
 1 27
10 M9365 GNF2 SERPINB5 Neighborhood of SERPINB5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.663E-2 4.418E-2
1.750E-1
4.822E-1
 1 28
11 M4051 MODULE 1 Ovary genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.823E-2 4.418E-2
1.750E-1
5.288E-1
 2 368
12 M876 MODULE 366 Breast cancer expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.957E-2 4.418E-2
1.750E-1
5.675E-1
 1 33
13 M18849 MODULE 153 Genes in the cancer module 153. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.016E-2 4.418E-2
1.750E-1
5.846E-1
 1 34
14 M59 MODULE 458 Genes in the cancer module 458. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.251E-2 4.418E-2
1.750E-1
6.527E-1
 1 38
15 M15763 MODULE 60 Heart genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.396E-2 4.418E-2
1.750E-1
6.948E-1
 2 425
16 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.492E-2 4.418E-2
1.750E-1
7.228E-1
 2 434
17 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.826E-2 4.418E-2
1.750E-1
8.196E-1
 2 464
18 M1288 MODULE 285 Genes in the cancer module 285. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.894E-2 4.418E-2
1.750E-1
8.394E-1
 1 49
19 M17449 MODULE 363 Genes in the cancer module 363. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.894E-2 4.418E-2
1.750E-1
8.394E-1
 1 49
Show 14 more annotations

16: MicroRNA [Display Chart] 6 input genes in category / 176 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-127-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.907E-8 1.568E-5 9.015E-5 1.568E-5 3 120
2 hsa-miR-876-5p:TargetScan hsa-miR-876-5p TargetScan 1.488E-4 1.106E-2
6.361E-2
 2.619E-2 2 229
3 hsa-miR-302f:PITA hsa-miR-302f:PITA TOP PITA 2.113E-4 1.106E-2
6.361E-2
 3.719E-2 2 273
4 hsa-miR-33b-5p:TargetScan hsa-miR-33b-5p TargetScan 4.498E-4 1.106E-2
6.361E-2
7.916E-2
 2 399
5 hsa-miR-33a-5p:TargetScan hsa-miR-33a-5p TargetScan 4.498E-4 1.106E-2
6.361E-2
7.916E-2
 2 399
6 hsa-miR-7-5p:TargetScan hsa-miR-7-5p TargetScan 4.633E-4 1.106E-2
6.361E-2
8.155E-2
 2 405
7 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 5.028E-4 1.106E-2
6.361E-2
8.849E-2
 2 422
8 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 5.028E-4 1.106E-2
6.361E-2
8.849E-2
 2 422
9 hsa-miR-92b*:mirSVR lowEffct hsa-miR-92b*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.763E-4 1.127E-2
6.480E-2
1.014E-1
 2 452
10 hsa-miR-553:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.303E-4 1.461E-2
8.403E-2
1.461E-1
 1 10
11 hsa-miR-6718-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.235E-3 2.698E-2
1.552E-1
5.693E-1
 1 39
12 hsa-miR-203b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.235E-3 2.698E-2
1.552E-1
5.693E-1
 1 39
13 hsa-miR-4460:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.897E-3 2.698E-2
1.552E-1
6.859E-1
 1 47
14 hsa-miR-6807-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 2.698E-2
1.552E-1
8.753E-1
 1 60
15 hsa-miR-561-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.139E-3 2.698E-2
1.552E-1
9.044E-1
 1 62
16 hsa-miR-4658:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 2.698E-2
1.552E-1
9.189E-1
 1 63
17 hsa-miR-6790-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 2.698E-2
1.552E-1
9.335E-1
 1 64
18 hsa-miR-3659:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 2.698E-2
1.552E-1
9.481E-1
 1 65
19 hsa-miR-539-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 2.698E-2
1.552E-1
9.772E-1
 1 67
20 hsa-miR-6804-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.698E-2
1.552E-1
1.000E0
 1 69
21 hsa-miR-6882-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.698E-2
1.552E-1
1.000E0
 1 69
22 hsa-miR-485-3p:Functional MTI Functional MTI miRTarbase 6.048E-3 2.698E-2
1.552E-1
1.000E0
 1 73
23 hsa-miR-1197:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 2.698E-2
1.552E-1
1.000E0
 1 74
24 hsa-miR-6796-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 2.698E-2
1.552E-1
1.000E0
 1 74
25 hsa-miR-4761-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 2.698E-2
1.552E-1
1.000E0
 1 77
26 hsa-miR-217:Functional MTI Functional MTI miRTarbase 6.626E-3 2.698E-2
1.552E-1
1.000E0
 1 80
27 hsa-miR-323a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.791E-3 2.698E-2
1.552E-1
1.000E0
 1 82
28 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 2.698E-2
1.552E-1
1.000E0
 1 83
29 hsa-miR-3130-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 2.698E-2
1.552E-1
1.000E0
 1 83
30 hsa-miR-3151-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 2.698E-2
1.552E-1
1.000E0
 1 85
31 hsa-miR-3119:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 2.698E-2
1.552E-1
1.000E0
 1 85
32 hsa-miR-5047:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.369E-3 2.698E-2
1.552E-1
1.000E0
 1 89
33 hsa-miR-432-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 2.698E-2
1.552E-1
1.000E0
 1 94
34 hsa-miR-4518:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 2.698E-2
1.552E-1
1.000E0
 1 94
35 hsa-miR-1266-5p:Functional MTI Functional MTI miRTarbase 7.865E-3 2.698E-2
1.552E-1
1.000E0
 1 95
36 hsa-miR-6782-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 2.698E-2
1.552E-1
1.000E0
 1 95
37 hsa-miR-4433b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.030E-3 2.698E-2
1.552E-1
1.000E0
 1 97
38 hsa-miR-409-5p:TargetScan hsa-miR-409-5p TargetScan 8.030E-3 2.698E-2
1.552E-1
1.000E0
 1 97
39 hsa-miR-6893-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.030E-3 2.698E-2
1.552E-1
1.000E0
 1 97
40 hsa-miR-6742-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 2.698E-2
1.552E-1
1.000E0
 1 98
41 hsa-miR-4418:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 2.698E-2
1.552E-1
1.000E0
 1 101
42 hsa-miR-4792:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 2.698E-2
1.552E-1
1.000E0
 1 101
43 hsa-miR-140-5p:Functional MTI Functional MTI miRTarbase 8.360E-3 2.698E-2
1.552E-1
1.000E0
 1 101
44 hsa-miR-509-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 2.698E-2
1.552E-1
1.000E0
 1 103
45 hsa-miR-509-3-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.607E-3 2.698E-2
1.552E-1
1.000E0
 1 104
46 hsa-miR-6885-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 2.698E-2
1.552E-1
1.000E0
 1 105
47 hsa-miR-3174:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.854E-3 2.698E-2
1.552E-1
1.000E0
 1 107
48 hsa-miR-4443:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.937E-3 2.698E-2
1.552E-1
1.000E0
 1 108
49 hsa-miR-875-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.019E-3 2.698E-2
1.552E-1
1.000E0
 1 109
50 hsa-miR-431-5p:TargetScan hsa-miR-431-5p TargetScan 9.184E-3 2.698E-2
1.552E-1
1.000E0
 1 111
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2410 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000018752 plakin Stitch 1.777E-15 4.282E-12 3.582E-11 4.282E-12 6 82
2 CID000448959 AC1L9MJT Stitch 3.262E-13 3.931E-10 3.288E-9 7.863E-10 6 192
3 CID000032518 kalinin Stitch 4.496E-10 3.612E-7 3.021E-6 1.084E-6 4 55
4 CID000445839 AC1L9INI Stitch 5.998E-10 3.614E-7 3.023E-6 1.446E-6 4 59
5 CID000448113 AC1L9LMC Stitch 2.418E-9 1.165E-6 9.748E-6 5.827E-6 4 83
6 CID000446537 C-cluster Stitch 1.952E-8 7.839E-6 6.557E-5 4.703E-5 4 139
7 CID000072363 L-lysyl-L-lysyl-L-lysine Stitch 3.617E-8 1.245E-5 1.042E-4 8.718E-5 4 162
8 CID011708451 2 IMA Stitch 1.070E-7 3.084E-5 2.580E-4 2.578E-4 3 41
9 CID000448761 AC1L9MBG Stitch 1.152E-7 3.084E-5 2.580E-4 2.776E-4 3 42
10 CID000027282 D-glucamine Stitch 1.423E-7 3.430E-5 2.869E-4 3.430E-4 3 45
11 CID000003892 NSC339663 Stitch 2.066E-7 4.526E-5 3.786E-4 4.979E-4 4 250
12 ctd:C070571 ML 7 CTD 3.604E-7 7.238E-5 6.055E-4 8.686E-4 3 61
13 CID011963505 5-Acetamido-5,6-Dihydro-4-Hydroxy-6-Isobutoxy-4h-Pyran-2-Carboxylic Acid Stitch 6.221E-7 1.153E-4 9.647E-4 1.499E-3 3 73
14 CID003085040 Cilligen Stitch 8.622E-7 1.484E-4 1.241E-3 2.078E-3 2 6
15 CID000011330 AC1L1X4J Stitch 1.609E-6 2.504E-4 2.094E-3 3.878E-3 2 8
16 ctd:C108830 Y 27632 CTD 1.662E-6 2.504E-4 2.094E-3 4.006E-3 3 101
17 CID000001711 AC1L1C2F Stitch 2.151E-6 3.049E-4 2.550E-3 5.183E-3 3 110
18 CID000008008 butyronitrile Stitch 7.807E-6 1.045E-3 8.744E-3 1.882E-2 2 17
19 433 DN 2-propylpentanoic acid; Down 200; 1000uM; PC3; HG-U133A Broad Institute CMAP Down 1.184E-5 1.358E-3 1.136E-2 2.854E-2 3 194
20 4804 DN Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.184E-5 1.358E-3 1.136E-2 2.854E-2 3 194
21 333 DN diclofenac sodium; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 1.203E-5 1.358E-3 1.136E-2 2.898E-2 3 195
22 1792 DN Meticrane [1084-65-7]; Down 200; 14.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.240E-5 1.358E-3 1.136E-2 2.988E-2 3 197
23 CID005359556 nigrosine Stitch 1.583E-5 1.659E-3 1.388E-2 3.815E-2 2 24
24 CID000005267 AC1Q6PCP Stitch 1.971E-5 1.979E-3 1.656E-2 4.750E-2 3 230
25 CID003269221 1-Formyl-4-methylpiperazine Stitch 2.167E-5 2.089E-3 1.747E-2
5.223E-2
 2 28
26 CID000161853 GK-101 Stitch 3.608E-5 3.345E-3 2.798E-2
8.696E-2
 2 36
27 CID000444689 AC1L9GQC Stitch 3.814E-5 3.405E-3 2.848E-2
9.192E-2
 2 37
28 CID000447989 (2s,5s)-5-Carboxymethylproline Stitch 4.991E-5 4.296E-3 3.594E-2
1.203E-1
 3 314
29 CID000108062 Madecassol Stitch 5.921E-5 4.921E-3 4.116E-2
1.427E-1
 2 46
30 CID000008439 AC1L1R04 Stitch 6.184E-5 4.968E-3 4.155E-2
1.490E-1
 2 47
31 CID000044562 d-indobufen Stitch 7.005E-5 5.276E-3 4.413E-2
1.688E-1
 2 50
32 CID000128647 mant-GTP Stitch 7.005E-5 5.276E-3 4.413E-2
1.688E-1
 2 50
33 CID005362391 ridogrel Stitch 7.581E-5 5.536E-3 4.631E-2
1.827E-1
 2 52
34 CID000023340 NSC49633 Stitch 7.877E-5 5.584E-3 4.671E-2
1.898E-1
 2 53
35 CID000003961 losartan Stitch 8.666E-5 5.891E-3 4.928E-2
2.089E-1
 3 378
36 CID000002349 penicillin Stitch 8.800E-5 5.891E-3 4.928E-2
2.121E-1
 2 56
37 CID000470146 AC1LAKND Stitch 1.080E-4 7.034E-3
5.883E-2
2.602E-1
 2 62
38 CID011987767 (2R)-2-[(R)-carboxy-[[(2Z)-2-(2-furyl)-2-methoxyimino-acetyl]amino]methyl]-5-methylene-2H-1,3-thiazine-4-carboxylic acid Stitch 1.151E-4 7.299E-3
6.106E-2
2.774E-1
 2 64
39 CID011963508 2f1b Stitch 1.262E-4 7.797E-3
6.522E-2
3.041E-1
 2 67
40 CID000001647 BAPN Stitch 1.418E-4 8.332E-3
6.970E-2
3.416E-1
 2 71
41 CID000004006 malotilate Stitch 1.418E-4 8.332E-3
6.970E-2
3.416E-1
 2 71
42 CID005034185 AC1NMZ1B Stitch 1.582E-4 8.868E-3
7.418E-2
3.813E-1
 2 75
43 CID000447607 isofagomine Stitch 1.582E-4 8.868E-3
7.418E-2
3.813E-1
 2 75
44 CID006918182 strontium ranelate Stitch 1.668E-4 9.136E-3
7.642E-2
4.020E-1
 2 77
45 CID000030956 AC1L1KMJ Stitch 1.717E-4 9.193E-3
7.690E-2
4.137E-1
 3 476
46 CID000062891 halofuginone lactate Stitch 2.033E-4 1.065E-2
8.910E-2
4.900E-1
 2 85
47 CID000000825 4-hydroxyproline Stitch 2.330E-4 1.109E-2
9.276E-2
5.616E-1
 2 91
48 CID000174850 deep heat Stitch 2.627E-4 1.109E-2
9.276E-2
6.331E-1
 1 1
49 CID000030398 7-methylheptadecane Stitch 2.627E-4 1.109E-2
9.276E-2
6.331E-1
 1 1
50 CID000193777 Ro 6-0787 Stitch 2.627E-4 1.109E-2
9.276E-2
6.331E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 278 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0162154 Atrophic scar DisGeNET Curated 1.596E-11 4.436E-9 2.754E-8 4.436E-9 4 18
2 C0014527 Epidermolysis Bullosa DisGeNET Curated 6.593E-11 9.164E-9 5.688E-8 1.833E-8 4 25
3 C4025327 Congenital pyloric atresia DisGeNET Curated 2.820E-10 2.613E-8 1.622E-7 7.839E-8 3 5
4 C1856954 Plantar hyperkeratosis DisGeNET Curated 9.866E-10 6.857E-8 4.256E-7 2.743E-7 3 7
5 C1112570 Paraneoplastic pemphigus DisGeNET BeFree 3.381E-9 1.567E-7 9.724E-7 9.400E-7 3 10
6 C0853945 Oral mucosal blistering DisGeNET Curated 3.381E-9 1.567E-7 9.724E-7 9.400E-7 3 10
7 C0079301 Junctional Epidermolysis Bullosa DisGeNET Curated 6.197E-9 2.461E-7 1.528E-6 1.723E-6 3 12
8 C0265989 Congenital scar DisGeNET Curated 8.055E-9 2.488E-7 1.544E-6 2.239E-6 3 13
9 C3806301 Scarring alopecia of scalp DisGeNET Curated 8.055E-9 2.488E-7 1.544E-6 2.239E-6 3 13
10 C0345996 Milium Cyst DisGeNET Curated 1.914E-8 5.321E-7 3.303E-6 5.321E-6 3 17
11 C0265998 ANONYCHIA DisGeNET Curated 4.981E-8 1.259E-6 7.813E-6 1.385E-5 3 23
12 C0079298 Epidermolysis Bullosa Simplex DisGeNET Curated 6.467E-8 1.498E-6 9.299E-6 1.798E-5 3 25
13 C4025699 Abnormality of the stomach DisGeNET Curated 1.142E-7 2.269E-6 1.408E-5 3.176E-5 2 2
14 C2677349 Epidermolysis Bullosa Simplex With Pyloric Atresia DisGeNET Curated 1.142E-7 2.269E-6 1.408E-5 3.176E-5 2 2
15 C4023812 Aplasia of the bladder DisGeNET Curated 3.427E-7 5.293E-6 3.285E-5 9.527E-5 2 3
16 C1832926 EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder) DisGeNET Curated 3.427E-7 5.293E-6 3.285E-5 9.527E-5 2 3
17 cv:C1856934 Epidermolysis bullosa with pyloric atresia Clinical Variations 3.427E-7 5.293E-6 3.285E-5 9.527E-5 2 3
18 OMIN:226730 EPIDERMOLYSIS BULLOSA JUNCTIONALIS WITH PYLORIC ATRESIA OMIM 3.427E-7 5.293E-6 3.285E-5 9.527E-5 2 3
19 C0030805 Bullous pemphigoid DisGeNET Curated 5.163E-7 7.555E-6 4.689E-5 1.435E-4 3 49
20 C0406632 Autoimmune skin disease DisGeNET BeFree 6.853E-7 9.072E-6 5.630E-5 1.905E-4 2 4
21 C0740927 Elevated maternal serum alpha-fetoprotein DisGeNET Curated 6.853E-7 9.072E-6 5.630E-5 1.905E-4 2 4
22 C0221260 Dystrophia unguium DisGeNET Curated 7.346E-7 9.283E-6 5.761E-5 2.042E-4 3 55
23 C1834405 Nail dysplasia DisGeNET Curated 7.761E-7 9.380E-6 5.822E-5 2.158E-4 3 56
24 C1856953 Palmar hyperhidrosis DisGeNET Curated 1.142E-6 1.134E-5 7.037E-5 3.175E-4 2 5
25 OMIN:226650 EPIDERMOLYSIS BULLOSA, JUNCTIONAL, NON-HERLITZ TYPE OMIM 1.142E-6 1.134E-5 7.037E-5 3.175E-4 2 5
26 C0079299 Epidermolysis Bullosa Simplex Kobner DisGeNET Curated 1.142E-6 1.134E-5 7.037E-5 3.175E-4 2 5
27 C0268374 Adult junctional epidermolysis bullosa (disorder) DisGeNET Curated 1.142E-6 1.134E-5 7.037E-5 3.175E-4 2 5
28 cv:C0268374 Adult junctional epidermolysis bullosa Clinical Variations 1.142E-6 1.134E-5 7.037E-5 3.175E-4 2 5
29 C0041960 Ureterocele DisGeNET Curated 1.713E-6 1.488E-5 9.234E-5 4.761E-4 2 6
30 C1844738 Axillary pterygia DisGeNET Curated 1.713E-6 1.488E-5 9.234E-5 4.761E-4 2 6
31 C4021730 Junctional split DisGeNET Curated 1.713E-6 1.488E-5 9.234E-5 4.761E-4 2 6
32 C1856934 Epidermolysis bullosa with pyloric atresia DisGeNET Curated 1.713E-6 1.488E-5 9.234E-5 4.761E-4 2 6
33 C4280623 Rotting teeth DisGeNET Curated 1.810E-6 1.525E-5 9.466E-5 5.033E-4 3 74
34 C0266159 Pyloric Atresia DisGeNET Curated 2.397E-6 1.904E-5 1.182E-4 6.664E-4 2 7
35 C0743178 Diarrhea, intractable DisGeNET Curated 2.397E-6 1.904E-5 1.182E-4 6.664E-4 2 7
36 C4024942 Late-onset muscular dystrophy DisGeNET BeFree 3.196E-6 2.401E-5 1.490E-4 8.884E-4 2 8
37 C0080276 Disorder of the genitourinary system DisGeNET Curated 3.196E-6 2.401E-5 1.490E-4 8.884E-4 2 8
38 C4020895 Genitourinary dysplasia DisGeNET Curated 4.108E-6 3.005E-5 1.865E-4 1.142E-3 2 9
39 C0162119 Hemoglobin low DisGeNET Curated 9.242E-6 6.588E-5 4.089E-4 2.569E-3 3 127
40 C1856963 Fragile nails DisGeNET Curated 1.368E-5 9.506E-5 5.900E-4 3.803E-3 2 16
41 C0011334 Dental caries DisGeNET Curated 1.405E-5 9.525E-5 5.912E-4 3.905E-3 3 146
42 C0041974 Urethral Stricture DisGeNET Curated 1.743E-5 1.127E-4 6.996E-4 4.847E-3 2 18
43 C0241181 Fragile skin DisGeNET Curated 1.743E-5 1.127E-4 6.996E-4 4.847E-3 2 18
44 C0013592 Ectropion DisGeNET Curated 2.392E-5 1.511E-4 9.379E-4 6.649E-3 2 21
45 C0282160 Aplasia Cutis Congenita DisGeNET Curated 3.190E-5 1.971E-4 1.223E-3 8.869E-3 3 192
46 C1260926 Abnormal pigmentation DisGeNET Curated 3.414E-5 2.020E-4 1.254E-3 9.492E-3 2 25
47 C0042063 Urogenital Abnormalities DisGeNET Curated 3.414E-5 2.020E-4 1.254E-3 9.492E-3 2 25
48 C0014850 Esophageal Atresia DisGeNET Curated 4.618E-5 2.675E-4 1.660E-3 1.284E-2 2 29
49 C1862863 Sparse body hair DisGeNET Curated 5.639E-5 3.199E-4 1.986E-3 1.568E-2 2 32
50 C3899988 Autosomal Recessive Disorder DisGeNET BeFree 6.522E-5 3.546E-4 2.201E-3 1.813E-2 3 244
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