Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc67_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 21 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005545 1-phosphatidylinositol binding 2.838E-8 5.959E-7 2.172E-6 5.959E-7 3 22
2 GO:0035091 phosphatidylinositol binding 3.023E-5 3.174E-4 1.157E-3 6.348E-4 3 217
3 GO:0005543 phospholipid binding 1.664E-4 1.165E-3 4.246E-3 3.494E-3 3 385
4 GO:0008565 protein transporter activity 4.290E-4 2.252E-3 8.209E-3 9.008E-3 2 101
5 GO:0030250 guanylate cyclase activator activity 2.249E-3 7.588E-3 2.766E-2 4.723E-2 1 7
6 GO:0010853 cyclase activator activity 2.249E-3 7.588E-3 2.766E-2 4.723E-2 1 7
7 GO:0030249 guanylate cyclase regulator activity 2.570E-3 7.588E-3 2.766E-2
5.397E-2
 1 8
8 GO:0010851 cyclase regulator activity 2.891E-3 7.588E-3 2.766E-2
6.070E-2
 1 9
9 GO:0051428 peptide hormone receptor binding 5.454E-3 1.273E-2 4.639E-2
1.145E-1
 1 17
10 GO:0030742 GTP-dependent protein binding 7.054E-3 1.481E-2
5.400E-2
1.481E-1
 1 22
11 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1.279E-2 2.442E-2
8.904E-2
2.687E-1
 1 40
12 GO:0046332 SMAD binding 2.451E-2 4.289E-2
1.563E-1
5.146E-1
 1 77
Show 7 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 92 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006622 protein targeting to lysosome 1.174E-5 9.166E-4 4.679E-3 1.080E-3 2 17
2 GO:0061462 protein localization to lysosome 1.993E-5 9.166E-4 4.679E-3 1.833E-3 2 22
3 GO:0006623 protein targeting to vacuole 4.831E-5 9.487E-4 4.843E-3 4.444E-3 2 34
4 GO:0072666 establishment of protein localization to vacuole 5.123E-5 9.487E-4 4.843E-3 4.713E-3 2 35
5 GO:0016197 endosomal transport 5.156E-5 9.487E-4 4.843E-3 4.743E-3 3 259
6 GO:0007034 vacuolar transport 7.072E-5 1.084E-3 5.535E-3 6.506E-3 3 288
7 GO:0072665 protein localization to vacuole 1.183E-4 1.555E-3 7.939E-3 1.089E-2 2 53
8 GO:0007041 lysosomal transport 2.570E-4 2.695E-3 1.375E-2 2.364E-2 2 78
9 GO:0051469 vesicle fusion with vacuole 3.222E-4 2.695E-3 1.375E-2 2.964E-2 1 1
10 GO:0099532 synaptic vesicle endosomal processing 3.222E-4 2.695E-3 1.375E-2 2.964E-2 1 1
11 GO:0016189 synaptic vesicle to endosome fusion 3.222E-4 2.695E-3 1.375E-2 2.964E-2 1 1
12 GO:0007033 vacuole organization 1.948E-3 1.493E-2
7.623E-2
1.792E-1
 2 216
13 GO:0030100 regulation of endocytosis 2.130E-3 1.507E-2
7.694E-2
1.959E-1
 2 226
14 GO:0031284 positive regulation of guanylate cyclase activity 3.539E-3 2.326E-2
1.187E-1
3.256E-1
 1 11
15 GO:0031282 regulation of guanylate cyclase activity 4.182E-3 2.469E-2
1.260E-1
3.847E-1
 1 13
16 GO:0007183 SMAD protein complex assembly 4.503E-3 2.469E-2
1.260E-1
4.142E-1
 1 14
17 GO:1903543 positive regulation of exosomal secretion 4.824E-3 2.469E-2
1.260E-1
4.438E-1
 1 15
18 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 4.831E-3 2.469E-2
1.260E-1
4.445E-1
 2 343
19 GO:0016050 vesicle organization 5.110E-3 2.474E-2
1.263E-1
4.701E-1
 2 353
20 GO:1903541 regulation of exosomal secretion 5.465E-3 2.514E-2
1.283E-1
5.028E-1
 1 17
21 GO:1990182 exosomal secretion 6.748E-3 2.956E-2
1.509E-1
6.208E-1
 1 21
22 GO:0036258 multivesicular body assembly 9.628E-3 3.778E-2
1.929E-1
8.858E-1
 1 30
23 GO:0036257 multivesicular body organization 9.948E-3 3.778E-2
1.929E-1
9.152E-1
 1 31
24 GO:0006182 cGMP biosynthetic process 1.027E-2 3.778E-2
1.929E-1
9.446E-1
 1 32
25 GO:0097576 vacuole fusion 1.027E-2 3.778E-2
1.929E-1
9.446E-1
 1 32
26 GO:0045022 early endosome to late endosome transport 1.123E-2 3.972E-2
2.027E-1
1.000E0
 1 35
27 GO:0098927 vesicle-mediated transport between endosomal compartments 1.218E-2 4.151E-2
2.119E-1
1.000E0
 1 38
28 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1.473E-2 4.418E-2
2.255E-1
1.000E0
 1 46
29 GO:1901185 negative regulation of ERBB signaling pathway 1.505E-2 4.418E-2
2.255E-1
1.000E0
 1 47
30 GO:0008333 endosome to lysosome transport 1.505E-2 4.418E-2
2.255E-1
1.000E0
 1 47
31 GO:0046426 negative regulation of JAK-STAT cascade 1.537E-2 4.418E-2
2.255E-1
1.000E0
 1 48
32 GO:1904893 negative regulation of STAT cascade 1.537E-2 4.418E-2
2.255E-1
1.000E0
 1 48
33 GO:0046068 cGMP metabolic process 1.632E-2 4.550E-2
2.323E-1
1.000E0
 1 51
Show 28 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 18 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031901 early endosome membrane 4.183E-11 7.529E-10 2.632E-9 7.529E-10 5 114
2 GO:0005769 early endosome 6.958E-9 6.262E-8 2.189E-7 1.252E-7 5 314
3 GO:0010008 endosome membrane 2.312E-8 1.387E-7 4.849E-7 4.162E-7 5 399
4 GO:0044440 endosomal part 3.522E-8 1.585E-7 5.540E-7 6.340E-7 5 434
5 GO:0005969 serine-pyruvate aminotransferase complex 3.148E-4 1.133E-3 3.961E-3 5.666E-3 1 1
6 GO:0033565 ESCRT-0 complex 9.441E-4 2.832E-3 9.899E-3 1.699E-2 1 3
7 GO:0044308 axonal spine 1.259E-3 3.236E-3 1.131E-2 2.266E-2 1 4
8 GO:0005770 late endosome 1.999E-3 4.498E-3 1.572E-2 3.599E-2 2 224
9 GO:0032585 multivesicular body membrane 2.830E-3 5.660E-3 1.978E-2
5.094E-2
 1 9
10 GO:0036452 ESCRT complex 8.157E-3 1.468E-2
5.132E-2
1.468E-1
 1 26
11 GO:0005771 multivesicular body 1.439E-2 2.355E-2
8.233E-2
2.591E-1
 1 46
Show 6 more annotations

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1 input genes in category / 112 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020533 decreased pons size 1.931E-4 1.236E-2
6.552E-2
 2.163E-2 1 2
2 MP:0020532 abnormal pons size 3.863E-4 1.236E-2
6.552E-2
 4.326E-2 1 4
3 MP:0004706 short vertebral body 5.794E-4 1.236E-2
6.552E-2
6.490E-2
 1 6
4 MP:0002880 opisthotonus 6.760E-4 1.236E-2
6.552E-2
7.571E-2
 1 7
5 MP:0012484 decreased corticospinal tract size 6.760E-4 1.236E-2
6.552E-2
7.571E-2
 1 7
6 MP:0012083 absent foregut 7.726E-4 1.236E-2
6.552E-2
8.653E-2
 1 8
7 MP:0009393 abnormal resting posture 7.726E-4 1.236E-2
6.552E-2
8.653E-2
 1 8
8 MP:0004557 dilated allantois 9.657E-4 1.322E-2
7.007E-2
1.082E-1
 1 10
9 MP:0012263 decreased hindbrain size 1.352E-3 1.322E-2
7.007E-2
1.514E-1
 1 14
10 MP:0004670 small vertebral body 1.642E-3 1.322E-2
7.007E-2
1.839E-1
 1 17
11 MP:0000956 decreased spinal cord size 1.642E-3 1.322E-2
7.007E-2
1.839E-1
 1 17
12 MP:0012262 abnormal hindbrain size 1.738E-3 1.322E-2
7.007E-2
1.947E-1
 1 18
13 MP:0006099 thin cerebellar granule layer 1.738E-3 1.322E-2
7.007E-2
1.947E-1
 1 18
14 MP:0003225 axonal dystrophy 1.738E-3 1.322E-2
7.007E-2
1.947E-1
 1 18
15 MP:0004187 cardia bifida 1.931E-3 1.322E-2
7.007E-2
2.163E-1
 1 20
16 MP:0004601 abnormal vertebral spinous process morphology 2.028E-3 1.322E-2
7.007E-2
2.271E-1
 1 21
17 MP:0005424 jerky movement 2.125E-3 1.322E-2
7.007E-2
2.380E-1
 1 22
18 MP:0002878 abnormal corticospinal tract morphology 2.125E-3 1.322E-2
7.007E-2
2.380E-1
 1 22
19 MP:0012089 decreased midbrain size 2.511E-3 1.480E-2
7.845E-2
2.812E-1
 1 26
20 MP:0000846 abnormal medulla oblongata morphology 3.187E-3 1.562E-2
8.281E-2
3.569E-1
 1 33
21 MP:0004000 impaired passive avoidance behavior 3.283E-3 1.562E-2
8.281E-2
3.677E-1
 1 34
22 MP:0012088 abnormal midbrain size 3.477E-3 1.562E-2
8.281E-2
3.894E-1
 1 36
23 MP:0001253 abnormal body height 3.670E-3 1.562E-2
8.281E-2
4.110E-1
 1 38
24 MP:0008027 abnormal spinal cord white matter morphology 3.670E-3 1.562E-2
8.281E-2
4.110E-1
 1 38
25 MP:0000474 abnormal foregut morphology 3.670E-3 1.562E-2
8.281E-2
4.110E-1
 1 38
26 MP:0001255 decreased body height 3.670E-3 1.562E-2
8.281E-2
4.110E-1
 1 38
27 MP:0012312 impaired avoidance learning behavior 3.766E-3 1.562E-2
8.281E-2
4.218E-1
 1 39
28 MP:0002573 behavioral despair 3.959E-3 1.584E-2
8.394E-2
4.435E-1
 1 41
29 MP:0000930 wavy neural tube 4.153E-3 1.604E-2
8.500E-2
4.651E-1
 1 43
30 MP:0001409 increased stereotypic behavior 4.442E-3 1.658E-2
8.790E-2
4.975E-1
 1 46
31 MP:0003460 decreased fear-related response 4.829E-3 1.718E-2
9.105E-2
5.408E-1
 1 50
32 MP:0005156 bradykinesia 4.925E-3 1.718E-2
9.105E-2
5.516E-1
 1 51
33 MP:0002799 abnormal passive avoidance behavior 5.215E-3 1.718E-2
9.105E-2
5.841E-1
 1 54
34 MP:0003062 abnormal coping response 5.215E-3 1.718E-2
9.105E-2
5.841E-1
 1 54
35 MP:0000848 abnormal pons morphology 5.601E-3 1.792E-2
9.500E-2
6.273E-1
 1 58
36 MP:0004180 failure of initiation of embryo turning 5.891E-3 1.812E-2
9.606E-2
6.598E-1
 1 61
37 MP:0009346 decreased trabecular bone thickness 5.987E-3 1.812E-2
9.606E-2
6.706E-1
 1 62
38 MP:0009657 failure of chorioallantoic fusion 6.374E-3 1.854E-2
9.827E-2
7.139E-1
 1 66
39 MP:0000141 abnormal vertebral body morphology 6.470E-3 1.854E-2
9.827E-2
7.247E-1
 1 67
40 MP:0009940 abnormal hippocampus pyramidal cell morphology 6.663E-3 1.854E-2
9.827E-2
7.463E-1
 1 69
41 MP:0003106 abnormal fear-related response 6.857E-3 1.854E-2
9.827E-2
7.679E-1
 1 71
42 MP:0000743 muscle spasm 6.953E-3 1.854E-2
9.827E-2
7.788E-1
 1 72
43 MP:0009046 muscle twitch 7.243E-3 1.887E-2
9.999E-2
8.112E-1
 1 75
44 MP:0001522 impaired swimming 7.533E-3 1.917E-2
1.016E-1
8.437E-1
 1 78
45 MP:0003871 abnormal myelin sheath morphology 7.726E-3 1.923E-2
1.019E-1
8.653E-1
 1 80
46 MP:0000876 Purkinje cell degeneration 8.209E-3 1.999E-2
1.059E-1
9.194E-1
 1 85
47 MP:0008284 abnormal hippocampus pyramidal cell layer 8.498E-3 2.005E-2
1.063E-1
9.518E-1
 1 88
48 MP:0001462 abnormal avoidance learning behavior 8.595E-3 2.005E-2
1.063E-1
9.626E-1
 1 89
49 MP:0002824 abnormal chorioallantoic fusion 8.788E-3 2.009E-2
1.065E-1
9.843E-1
 1 91
50 MP:0012315 impaired learning 8.981E-3 2.012E-2
1.066E-1
1.000E0
 1 93
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 33 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00064 FYVE SMART 3.702E-14 6.109E-13 2.498E-12 1.222E-12 5 29
2 PF01363 FYVE Pfam 3.702E-14 6.109E-13 2.498E-12 1.222E-12 5 29
3 IPR017455 Znf FYVE-rel InterPro 8.673E-14 9.541E-13 3.901E-12 2.862E-12 5 34
4 IPR000306 Znf FYVE InterPro 1.564E-13 1.291E-12 5.277E-12 5.162E-12 5 38
5 PS50178 ZF FYVE PROSITE 2.050E-13 1.353E-12 5.533E-12 6.767E-12 5 40
6 IPR011011 Znf FYVE PHD InterPro 1.656E-10 9.109E-10 3.724E-9 5.465E-9 5 147
7 3.30.40.10 - Gene3D 4.550E-8 2.095E-7 8.567E-7 1.501E-6 5 449
8 IPR013083 Znf RING/FYVE/PHD InterPro 5.080E-8 2.095E-7 8.567E-7 1.676E-6 5 459
9 PF11979 DUF3480 Pfam 8.547E-8 2.564E-7 1.048E-6 2.821E-6 2 2
10 IPR017165 Znf FYVE endofin InterPro 8.547E-8 2.564E-7 1.048E-6 2.821E-6 2 2
11 IPR022557 DUF3480 InterPro 8.547E-8 2.564E-7 1.048E-6 2.821E-6 2 2
12 SM00593 RUN SMART 1.305E-5 3.208E-5 1.312E-4 4.306E-4 2 18
13 PS50826 RUN PROSITE 1.458E-5 3.208E-5 1.312E-4 4.812E-4 2 19
14 PF02759 RUN Pfam 1.458E-5 3.208E-5 1.312E-4 4.812E-4 2 19
15 IPR004012 Run dom InterPro 1.458E-5 3.208E-5 1.312E-4 4.812E-4 2 19
16 IPR024608 SARA Smad-bd InterPro 3.203E-4 5.033E-4 2.058E-3 1.057E-2 1 1
17 PF12210 Hrs helical Pfam 3.203E-4 5.033E-4 2.058E-3 1.057E-2 1 1
18 PF11409 SARA Pfam 3.203E-4 5.033E-4 2.058E-3 1.057E-2 1 1
19 4.10.720.10 - Gene3D 3.203E-4 5.033E-4 2.058E-3 1.057E-2 1 1
20 IPR017073 Ubi-bd Hrs VPS27 InterPro 3.203E-4 5.033E-4 2.058E-3 1.057E-2 1 1
21 IPR024641 HRS helical InterPro 3.203E-4 5.033E-4 2.058E-3 1.057E-2 1 1
22 PF00790 VHS Pfam 2.879E-3 3.801E-3 1.554E-2
9.501E-2
 1 9
23 PS50179 VHS PROSITE 2.879E-3 3.801E-3 1.554E-2
9.501E-2
 1 9
24 IPR002014 VHS dom InterPro 2.879E-3 3.801E-3 1.554E-2
9.501E-2
 1 9
25 SM00288 VHS SMART 2.879E-3 3.801E-3 1.554E-2
9.501E-2
 1 9
26 PF02809 UIM Pfam 5.752E-3 7.300E-3 2.985E-2
1.898E-1
 1 18
27 SM00726 UIM SMART 6.707E-3 8.198E-3 3.352E-2
2.213E-1
 1 21
28 PS50330 UIM PROSITE 7.663E-3 9.031E-3 3.693E-2
2.529E-1
 1 24
29 IPR003903 UIM dom InterPro 7.981E-3 9.082E-3 3.713E-2
2.634E-1
 1 25
30 1.25.40.90 - Gene3D 8.299E-3 9.129E-3 3.733E-2
2.739E-1
 1 26
31 IPR008942 ENTH VHS InterPro 9.253E-3 9.850E-3 4.027E-2
3.053E-1
 1 29
32 IPR009053 Prefoldin InterPro 2.284E-2 2.355E-2
9.631E-2
7.538E-1
 1 72
Show 27 more annotations

7: Pathway [Display Chart] 5 input genes in category / 44 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 102279 Endocytosis BioSystems: KEGG 3.824E-9 1.683E-7 7.358E-7 1.683E-7 5 260
2 138024 TGF-beta receptor signaling BioSystems: Pathway Interaction Database 1.632E-4 3.591E-3 1.570E-2 7.182E-3 2 51
3 83064 TGF-beta signaling pathway BioSystems: KEGG 4.439E-4 5.730E-3 2.506E-2 1.953E-2 2 84
4 P00052 TGF-beta signaling pathway PantherDB 5.209E-4 5.730E-3 2.506E-2 2.292E-2 2 91
5 153910 Phagosome BioSystems: KEGG 1.483E-3 1.305E-2
5.708E-2
6.527E-2
 2 154
6 1268898 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 2.408E-3 1.412E-2
6.175E-2
1.059E-1
 1 6
7 1268897 Loss of Function of SMAD2/3 in Cancer BioSystems: REACTOME 2.809E-3 1.412E-2
6.175E-2
1.236E-1
 1 7
8 1268899 SMAD2/3 MH2 Domain Mutants in Cancer BioSystems: REACTOME 2.809E-3 1.412E-2
6.175E-2
1.236E-1
 1 7
9 1268903 Loss of Function of TGFBR1 in Cancer BioSystems: REACTOME 3.209E-3 1.412E-2
6.175E-2
1.412E-1
 1 8
10 1268905 TGFBR1 KD Mutants in Cancer BioSystems: REACTOME 3.209E-3 1.412E-2
6.175E-2
1.412E-1
 1 8
11 1268894 Signaling by TGF-beta Receptor Complex in Cancer BioSystems: REACTOME 3.610E-3 1.444E-2
6.314E-2
1.588E-1
 1 9
12 1470919 InlB-mediated entry of Listeria monocytogenes into host cell BioSystems: REACTOME 6.011E-3 2.204E-2
9.637E-2
2.645E-1
 1 15
13 M18933 TGF beta signaling pathway MSigDB C2 BIOCARTA (v6.0) 7.608E-3 2.346E-2
1.026E-1
3.348E-1
 1 19
14 1470917 Listeria monocytogenes entry into host cells BioSystems: REACTOME 8.008E-3 2.346E-2
1.026E-1
3.523E-1
 1 20
15 1457805 Negative regulation of MET activity BioSystems: REACTOME 8.407E-3 2.346E-2
1.026E-1
3.699E-1
 1 21
16 M8809 Phosphoinositides and their downstream targets. MSigDB C2 BIOCARTA (v6.0) 9.204E-3 2.346E-2
1.026E-1
4.050E-1
 1 23
17 1269522 Signaling by BMP BioSystems: REACTOME 9.603E-3 2.346E-2
1.026E-1
4.225E-1
 1 24
18 1269385 EGFR downregulation BioSystems: REACTOME 1.000E-2 2.346E-2
1.026E-1
4.401E-1
 1 25
19 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 1.040E-2 2.346E-2
1.026E-1
4.576E-1
 1 26
20 1269525 Downregulation of TGF-beta receptor signaling BioSystems: REACTOME 1.080E-2 2.346E-2
1.026E-1
4.751E-1
 1 27
21 1269895 Endosomal Sorting Complex Required For Transport (ESCRT) BioSystems: REACTOME 1.120E-2 2.346E-2
1.026E-1
4.926E-1
 1 28
22 138013 Internalization of ErbB1 BioSystems: Pathway Interaction Database 1.358E-2 2.530E-2
1.106E-1
5.976E-1
 1 34
23 1269524 TGF-beta receptor signaling activates SMADs BioSystems: REACTOME 1.358E-2 2.530E-2
1.106E-1
5.976E-1
 1 34
24 137948 BMP receptor signaling BioSystems: Pathway Interaction Database 1.438E-2 2.530E-2
1.106E-1
6.326E-1
 1 36
25 1269883 Lysosome Vesicle Biogenesis BioSystems: REACTOME 1.438E-2 2.530E-2
1.106E-1
6.326E-1
 1 36
26 1270077 Synthesis of PIPs at the plasma membrane BioSystems: REACTOME 1.992E-2 3.372E-2
1.474E-1
8.766E-1
 1 50
27 1457794 Signaling by MET BioSystems: REACTOME 2.741E-2 4.178E-2
1.827E-1
1.000E0
 1 69
28 137930 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) BioSystems: Pathway Interaction Database 2.859E-2 4.178E-2
1.827E-1
1.000E0
 1 72
29 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 2.898E-2 4.178E-2
1.827E-1
1.000E0
 1 73
30 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 2.898E-2 4.178E-2
1.827E-1
1.000E0
 1 73
31 137910 CXCR4-mediated signaling events BioSystems: Pathway Interaction Database 3.016E-2 4.178E-2
1.827E-1
1.000E0
 1 76
32 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 3.055E-2 4.178E-2
1.827E-1
1.000E0
 1 77
33 1270073 PI Metabolism BioSystems: REACTOME 3.133E-2 4.178E-2
1.827E-1
1.000E0
 1 79
34 1269233 Toll Like Receptor 9 (TLR9) Cascade BioSystems: REACTOME 3.836E-2 4.920E-2
2.151E-1
1.000E0
 1 97
35 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 3.914E-2 4.920E-2
2.151E-1
1.000E0
 1 99
Show 30 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 379 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12554698 SARA and Hgs attenuate susceptibility to TGF-beta1-mediated T cell suppression. Pubmed 2.057E-8 3.897E-6 2.540E-5 7.795E-6 2 2
2 16775010 Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA. Pubmed 2.057E-8 3.897E-6 2.540E-5 7.795E-6 2 2
3 16448788 Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1. Pubmed 6.170E-8 7.794E-6 5.079E-5 2.338E-5 2 3
4 11493665 FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. Pubmed 1.234E-7 9.352E-6 6.094E-5 4.676E-5 2 4
5 27471254 SARA regulates neuronal migration during neocortical development through L1 trafficking. Pubmed 1.234E-7 9.352E-6 6.094E-5 4.676E-5 2 4
6 29891722 HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion. Pubmed 2.056E-7 1.299E-5 8.463E-5 7.793E-5 2 5
7 11094085 Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Pubmed 4.318E-7 2.045E-5 1.333E-4 1.636E-4 2 7
8 18767904 Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. Pubmed 4.318E-7 2.045E-5 1.333E-4 1.636E-4 2 7
9 14613930 Endofin recruits TOM1 to endosomes. Pubmed 5.756E-7 2.424E-5 1.580E-4 2.182E-4 2 8
10 23222715 SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Pubmed 7.400E-7 2.805E-5 1.828E-4 2.805E-4 2 9
11 17356069 Endofin acts as a Smad anchor for receptor activation in BMP signaling. Pubmed 1.130E-6 3.895E-5 2.538E-4 4.284E-4 2 11
12 29568061 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Pubmed 7.648E-5 9.214E-4 6.004E-3 2.899E-2 2 87
13 15158678 Galactosylceramide expression factor-1 induces myogenesis in MDCK and C3H10T1/2 cells. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
14 11230696 Structural mechanism of endosome docking by the FYVE domain. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
15 20812348 Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
16 11877415 Early endosomal regulation of Smad-dependent signaling in endothelial cells. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
17 24368810 Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
18 26944198 Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
19 11741531 Multivalent endosome targeting by homodimeric EEA1. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
20 26159183 Smad Anchor for Receptor Activation Regulates High Glucose-Induced EMT via Modulation of Smad2 and Smad3 Activities in Renal Tubular Epithelial Cells. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
21 15944737 Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
22 7768953 EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
23 29547649 Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
24 28621434 EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
25 26358513 Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
26 26715116 A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
27 17545595 Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and beta-catenin. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
28 17624298 Role of Hrs in maturation of autophagosomes in mammalian cells. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
29 22915584 NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
30 27112194 ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
31 16331966 Investigation of the binding geometry of a peripheral membrane protein. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
32 6024256 The neuropathy of teetering, a neurological mutation in the mouse. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
33 11918675 The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
34 16084064 Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
35 10693761 Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
36 23566224 Early Endosome Antigen 1 (EEA1) decreases in macrophages infected with Paracoccidioides brasiliensis. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
37 15071556 The biogenesis of multivesicular endosomes. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
38 10394369 Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
39 10807926 Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
40 24491918 HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
41 21266541 Expression, purification, and functional characterization of recombinant PTD-SARA. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
42 17101784 Epidermal growth factor receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
43 17113235 Human autoantibodies against early endosome antigen-1 enhance excitatory synaptic transmission. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
44 16462748 Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
45 24204276 Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
46 19887107 EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
47 15052657 Association of early endosomal autoantigen 1 with macropinocytosis in EGF-stimulated A431 cells. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
48 22138215 Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
49 22832105 An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
50 17233583 Evolutionarily conserved structural and functional roles of the FYVE domain. Pubmed 1.571E-4 9.214E-4 6.004E-3
5.954E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 415 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RNF11 RNF11 interactions 5.690E-6 1.031E-3 6.813E-3 2.361E-3 3 118
2 int:ZFYVE16 ZFYVE16 interactions 7.455E-6 1.031E-3 6.813E-3 3.094E-3 2 13
3 int:WASHC1 WASHC1 interactions 7.455E-6 1.031E-3 6.813E-3 3.094E-3 2 13
4 int:MAGEB4 MAGEB4 interactions 2.862E-5 2.969E-3 1.962E-2 1.188E-2 2 25
5 int:TOM1 TOM1 interactions 7.804E-5 6.477E-3 4.279E-2 3.239E-2 2 41
6 int:EEA1 EEA1 interactions 1.072E-4 7.417E-3 4.900E-2 4.450E-2 2 48
7 int:PTPN23 PTPN23 interactions 1.515E-4 8.983E-3
5.935E-2
6.288E-2
 2 57
8 int:STAM2 STAM2 interactions 2.034E-4 1.055E-2
6.970E-2
8.440E-2
 2 66
9 int:RABEP1 RABEP1 interactions 2.421E-4 1.116E-2
7.376E-2
1.005E-1
 2 72
10 int:RALBP1 RALBP1 interactions 3.218E-4 1.244E-2
8.216E-2
1.336E-1
 2 83
11 int:VPS35 VPS35 interactions 3.296E-4 1.244E-2
8.216E-2
1.368E-1
 2 84
12 int:HSPBP1 HSPBP1 interactions 4.127E-4 1.427E-2
9.429E-2
1.713E-1
 2 94
13 int:STX12 STX12 interactions 4.763E-4 1.520E-2
1.004E-1
1.977E-1
 2 101
14 int:DAZAP2 DAZAP2 interactions 5.146E-4 1.526E-2
1.008E-1
2.136E-1
 2 105
15 int:GFI1B GFI1B interactions 6.169E-4 1.707E-2
1.128E-1
2.560E-1
 2 115
16 int:LINC00265 LINC00265 interactions 6.778E-4 1.758E-2
1.161E-1
2.813E-1
 1 2
17 int:RAB5A RAB5A interactions 7.399E-4 1.806E-2
1.193E-1
3.071E-1
 2 126
18 int:EPS15 EPS15 interactions 1.145E-3 2.640E-2
1.744E-1
4.753E-1
 2 157
19 int:TSG101 TSG101 interactions 1.551E-3 3.388E-2
2.238E-1
6.438E-1
 2 183
20 int:ASPA ASPA interactions 1.694E-3 3.514E-2
2.322E-1
7.029E-1
 1 5
21 int:MYO6 MYO6 interactions 1.867E-3 3.690E-2
2.438E-1
7.749E-1
 2 201
22 int:GRIK4 GRIK4 interactions 2.032E-3 3.833E-2
2.533E-1
8.433E-1
 1 6
23 int:RUNDC3B RUNDC3B interactions 2.370E-3 3.835E-2
2.534E-1
9.837E-1
 1 7
24 int:SVEP1 SVEP1 interactions 2.370E-3 3.835E-2
2.534E-1
9.837E-1
 1 7
25 int:TBRG1 TBRG1 interactions 3.385E-3 3.835E-2
2.534E-1
1.000E0
 1 10
26 int:CCDC186 CCDC186 interactions 3.385E-3 3.835E-2
2.534E-1
1.000E0
 1 10
27 int:PMEPA1 PMEPA1 interactions 3.385E-3 3.835E-2
2.534E-1
1.000E0
 1 10
28 int:TEKT1 TEKT1 interactions 3.723E-3 3.835E-2
2.534E-1
1.000E0
 1 11
29 int:ST8SIA1 ST8SIA1 interactions 3.723E-3 3.835E-2
2.534E-1
1.000E0
 1 11
30 int:RUBCNL RUBCNL interactions 3.723E-3 3.835E-2
2.534E-1
1.000E0
 1 11
31 int:CCDC114 CCDC114 interactions 3.723E-3 3.835E-2
2.534E-1
1.000E0
 1 11
32 int:IL2RA IL2RA interactions 3.723E-3 3.835E-2
2.534E-1
1.000E0
 1 11
33 int:VPS37D VPS37D interactions 4.061E-3 3.835E-2
2.534E-1
1.000E0
 1 12
34 int:RNPEP RNPEP interactions 4.061E-3 3.835E-2
2.534E-1
1.000E0
 1 12
35 int:SUMF2 SUMF2 interactions 4.061E-3 3.835E-2
2.534E-1
1.000E0
 1 12
36 int:SMAD2 SMAD2 interactions 4.267E-3 3.835E-2
2.534E-1
1.000E0
 2 306
37 int:ZNF302 ZNF302 interactions 4.399E-3 3.835E-2
2.534E-1
1.000E0
 1 13
38 int:SNX7 SNX7 interactions 4.399E-3 3.835E-2
2.534E-1
1.000E0
 1 13
39 int:RAB22A RAB22A interactions 4.736E-3 3.835E-2
2.534E-1
1.000E0
 1 14
40 int:TRAK1 TRAK1 interactions 4.736E-3 3.835E-2
2.534E-1
1.000E0
 1 14
41 int:RUFY2 RUFY2 interactions 4.736E-3 3.835E-2
2.534E-1
1.000E0
 1 14
42 int:AP3B2 AP3B2 interactions 4.736E-3 3.835E-2
2.534E-1
1.000E0
 1 14
43 int:CLTC CLTC interactions 5.004E-3 3.835E-2
2.534E-1
1.000E0
 2 332
44 int:TUBB TUBB interactions 5.033E-3 3.835E-2
2.534E-1
1.000E0
 2 333
45 int:PPP1CC PPP1CC interactions 5.063E-3 3.835E-2
2.534E-1
1.000E0
 2 334
46 int:RRAD RRAD interactions 5.074E-3 3.835E-2
2.534E-1
1.000E0
 1 15
47 int:EPDR1 EPDR1 interactions 5.074E-3 3.835E-2
2.534E-1
1.000E0
 1 15
48 int:BST2 BST2 interactions 5.074E-3 3.835E-2
2.534E-1
1.000E0
 1 15
49 int:AVPR2 AVPR2 interactions 5.074E-3 3.835E-2
2.534E-1
1.000E0
 1 15
50 int:JAKMIP2 JAKMIP2 interactions 5.074E-3 3.835E-2
2.534E-1
1.000E0
 1 15
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q14 5q14 1.730E-3 1.038E-2 2.543E-2 1.038E-2 1 10
2 17q25 17q25 6.733E-3 1.450E-2 3.552E-2 4.040E-2 1 39
3 12q22 12q22 7.249E-3 1.450E-2 3.552E-2 4.349E-2 1 42
4 1p32.3 1p32.3 1.051E-2 1.577E-2 3.864E-2
6.308E-2
 1 61
5 17q21.31 17q21.31 1.497E-2 1.753E-2 4.295E-2
8.980E-2
 1 87
6 5q35.3 5q35.3 1.753E-2 1.753E-2 4.295E-2
1.052E-1
 1 102
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 56 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 81 Zinc fingers FYVE-type genenames.org 1.023E-14 3.070E-14 5.628E-14 3.070E-14 5 31
2 1115 ESCRT-0 genenames.org 8.243E-4 1.236E-3 2.267E-3 2.473E-3 1 3
3 694 Protein phosphatase 1 regulatory subunits genenames.org 4.877E-2 4.877E-2
8.941E-2
1.463E-1
 1 181

13: Coexpression [Display Chart] 6 input genes in category / 448 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2954 Genes up-regulated in induced T reg cultured with IL2 [GeneID=3558]: wildtype versus non-functional FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 7.713E-4 4.440E-2
2.967E-1
3.455E-1
 2 168
2 M6516 Genes down-regulated in epithelial cells (6h): untreated versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 1.037E-3 4.440E-2
2.967E-1
4.644E-1
 2 195
3 19047894-Table2b Human Thyroid Amin09 4genes GeneSigDB 1.037E-3 4.440E-2
2.967E-1
4.646E-1
 1 4
4 M7263 Genes down-regulated in thymus perimedullary cortical region versus the whole cortex. MSigDB C7: Immunologic Signatures (v6.0) 1.047E-3 4.440E-2
2.967E-1
4.692E-1
 2 196
5 M5152 Genes up-regulated in comparison of dendritic cells (DC) versus DCs exposed to B. malayi (5 worms/well). MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 4.440E-2
2.967E-1
4.787E-1
 2 198
6 M5559 Genes up-regulated in comparison of basophils versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 4.440E-2
2.967E-1
4.835E-1
 2 199
7 M5586 Genes up-regulated in comparison of central memory CD4 [GeneID=920] T cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.440E-2
2.967E-1
4.883E-1
 2 200
8 M9755 Genes down-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Ly6c int CXCR5+ [GeneID=643] versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.440E-2
2.967E-1
4.883E-1
 2 200
9 M9075 Genes up-regulated in memory CD8 T cells, ITGAE- [GeneID=3682] population: brain versus spleen sources. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.440E-2
2.967E-1
4.883E-1
 2 200
10 M7276 Genes down-regulated in double positve thymocyte: TCF3 [GeneID=6929] knockout versus TCF3 and TCF12 [GeneID=6929;6938] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.440E-2
2.967E-1
4.883E-1
 2 200
11 M7168 Genes up-regulated in transitional B lymphocytes: CR2 [GeneID=1380] low versus CR2 [GeneID=1380] high. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.440E-2
2.967E-1
4.883E-1
 2 200
Show 6 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 184 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 3 input genes in category / 17 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 172 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-33a:PITA hsa-miR-33a:PITA TOP PITA 1.501E-4 6.151E-3 3.523E-2 2.582E-2 2 230
2 hsa-miR-33b:PITA hsa-miR-33b:PITA TOP PITA 1.514E-4 6.151E-3 3.523E-2 2.604E-2 2 231
3 hsa-miR-98:PITA hsa-miR-98:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
4 hsa-let-7c:PITA hsa-let-7c:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
5 hsa-let-7d:PITA hsa-let-7d:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
6 hsa-let-7g:PITA hsa-let-7g:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
7 hsa-let-7i:PITA hsa-let-7i:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
8 hsa-let-7e:PITA hsa-let-7e:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
9 hsa-let-7a:PITA hsa-let-7a:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
10 hsa-let-7b:PITA hsa-let-7b:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
11 hsa-let-7f:PITA hsa-let-7f:PITA TOP PITA 3.934E-4 6.151E-3 3.523E-2
6.766E-2
 2 373
12 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 4.387E-4 6.287E-3 3.601E-2
7.545E-2
 2 394
13 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 5.195E-4 6.873E-3 3.937E-2
8.935E-2
 2 429
14 hsa-miR-1915*:mirSVR highEffct hsa-miR-1915*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.993E-4 7.362E-3 4.217E-2
1.031E-1
 2 461
15 hsa-miR-6854-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.494E-3 1.713E-2
9.813E-2
2.570E-1
 1 18
16 hsa-miR-1225-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.986E-3 3.067E-2
1.757E-1
5.137E-1
 1 36
17 hsa-miR-4999-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.069E-3 3.067E-2
1.757E-1
5.279E-1
 1 37
18 hsa-miR-5002-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.401E-3 3.067E-2
1.757E-1
5.849E-1
 1 41
19 hsa-miR-509-3p:Functional MTI Functional MTI miRTarbase 3.401E-3 3.067E-2
1.757E-1
5.849E-1
 1 41
20 hsa-miR-591:Functional MTI Functional MTI miRTarbase 3.566E-3 3.067E-2
1.757E-1
6.134E-1
 1 43
21 hsa-miR-585-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.815E-3 3.124E-2
1.790E-1
6.561E-1
 1 46
22 hsa-miR-503-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 3.224E-2
1.847E-1
7.131E-1
 1 50
23 hsa-miR-4684-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 3.224E-2
1.847E-1
7.415E-1
 1 52
24 hsa-miR-601:PITA hsa-miR-601:PITA TOP PITA 4.808E-3 3.308E-2
1.895E-1
8.269E-1
 1 58
25 hsa-miR-1229-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 3.308E-2
1.895E-1
8.269E-1
 1 58
26 hsa-miR-5682:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.484E-2
1.996E-1
9.123E-1
 1 64
27 hsa-miR-3152-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.469E-3 3.484E-2
1.996E-1
9.407E-1
 1 66
28 hsa-miR-5004-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.512E-2
2.012E-1
9.834E-1
 1 69
29 hsa-miR-296-5p:Functional MTI Functional MTI miRTarbase 6.131E-3 3.636E-2
2.083E-1
1.000E0
 1 74
30 hsa-miR-936:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.791E-3 3.695E-2
2.116E-1
1.000E0
 1 82
31 hsa-miR-5195-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 3.695E-2
2.116E-1
1.000E0
 1 83
32 hsa-miR-769-5p:PITA hsa-miR-769-5p:PITA TOP PITA 6.874E-3 3.695E-2
2.116E-1
1.000E0
 1 83
33 hsa-miR-580-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.369E-3 3.759E-2
2.153E-1
1.000E0
 1 89
34 hsa-miR-7845-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.759E-2
2.153E-1
1.000E0
 1 98
35 hsa-miR-548au-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.759E-2
2.153E-1
1.000E0
 1 98
36 hsa-miR-644:PITA hsa-miR-644:PITA TOP PITA 8.360E-3 3.759E-2
2.153E-1
1.000E0
 1 101
37 hsa-miR-1286:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.759E-2
2.153E-1
1.000E0
 1 103
38 hsa-miR-6768-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.607E-3 3.759E-2
2.153E-1
1.000E0
 1 104
39 hsa-miR-4753-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.019E-3 3.759E-2
2.153E-1
1.000E0
 1 109
40 hsa-miR-610:PITA hsa-miR-610:PITA TOP PITA 9.926E-3 3.759E-2
2.153E-1
1.000E0
 1 120
41 hsa-miR-4328:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.058E-2 3.759E-2
2.153E-1
1.000E0
 1 128
42 hsa-miR-141-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.124E-2 3.759E-2
2.153E-1
1.000E0
 1 136
43 hsa-miR-891a:mirSVR highEffct hsa-miR-891a:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.133E-2 3.759E-2
2.153E-1
1.000E0
 1 137
44 hsa-miR-6847-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.256E-2 3.759E-2
2.153E-1
1.000E0
 1 152
45 hsa-miR-501-3p:TargetScan hsa-miR-501-3p TargetScan 1.264E-2 3.759E-2
2.153E-1
1.000E0
 1 153
46 hsa-miR-502-3p:TargetScan hsa-miR-502-3p TargetScan 1.264E-2 3.759E-2
2.153E-1
1.000E0
 1 153
47 hsa-miR-147:PITA hsa-miR-147:PITA TOP PITA 1.272E-2 3.759E-2
2.153E-1
1.000E0
 1 154
48 hsa-miR-3650:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.281E-2 3.759E-2
2.153E-1
1.000E0
 1 155
49 hsa-miR-367-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.338E-2 3.759E-2
2.153E-1
1.000E0
 1 162
50 hsa-miR-208a-3p:TargetScan hsa-miR-208a-3p TargetScan 1.338E-2 3.759E-2
2.153E-1
1.000E0
 1 162
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2100 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006857352 AC1OAGFW Stitch 6.171E-8 1.296E-4 1.066E-3 1.296E-4 4 185
2 2703 DN wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.148E-5 1.205E-2
9.917E-2
 2.411E-2 3 192
3 CID000024182 HgCl Stitch 6.726E-5 2.699E-2
2.221E-1
1.412E-1
 2 49
4 CID000002177 AC1L1D3F Stitch 1.756E-4 2.699E-2
2.221E-1
3.687E-1
 2 79
5 CID005473563 NSC11712 Stitch 2.627E-4 2.699E-2
2.221E-1
5.516E-1
 1 1
6 DB02942 Inositol 1,3-Bisphosphate Drug Bank 2.627E-4 2.699E-2
2.221E-1
5.516E-1
 1 1
7 CID000005563 triclofos Stitch 5.253E-4 2.699E-2
2.221E-1
1.000E0
 1 2
8 1745 UP Dihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; HL60; HG-U133A Broad Institute CMAP Up 7.819E-4 2.699E-2
2.221E-1
1.000E0
 2 167
9 CID006365403 teichuronic acid Stitch 7.879E-4 2.699E-2
2.221E-1
1.000E0
 1 3
10 CID003002043 5-propyl-2-thiouracil Stitch 7.879E-4 2.699E-2
2.221E-1
1.000E0
 1 3
11 CID000094406 N-(4-ethoxybenzylidene)-4-butylaniline Stitch 7.879E-4 2.699E-2
2.221E-1
1.000E0
 1 3
12 CID000643964 PtdIns(3)P Stitch 8.580E-4 2.699E-2
2.221E-1
1.000E0
 2 175
13 2859 DN Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 9.073E-4 2.699E-2
2.221E-1
1.000E0
 2 180
14 2474 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 9.787E-4 2.699E-2
2.221E-1
1.000E0
 2 187
15 4401 DN Apigenin [520-36-5]; Down 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 9.995E-4 2.699E-2
2.221E-1
1.000E0
 2 189
16 1807 UP Imipramine hydrochloride [113-52-0]; Up 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.995E-4 2.699E-2
2.221E-1
1.000E0
 2 189
17 1400 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP Up 1.010E-3 2.699E-2
2.221E-1
1.000E0
 2 190
18 1342 UP Naringenine [480-41-1]; Up 200; 14.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.021E-3 2.699E-2
2.221E-1
1.000E0
 2 191
19 5351 DN Ceforanide [60925-61-3]; Down 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.021E-3 2.699E-2
2.221E-1
1.000E0
 2 191
20 2937 DN Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.031E-3 2.699E-2
2.221E-1
1.000E0
 2 192
21 1562 UP Pimozide [2062-78-4]; Up 200; 8.6uM; HL60; HG-U133A Broad Institute CMAP Up 1.031E-3 2.699E-2
2.221E-1
1.000E0
 2 192
22 3976 DN Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.031E-3 2.699E-2
2.221E-1
1.000E0
 2 192
23 5437 UP Propafenone hydrochloride [34183-22-7]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.042E-3 2.699E-2
2.221E-1
1.000E0
 2 193
24 3773 DN PHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.042E-3 2.699E-2
2.221E-1
1.000E0
 2 193
25 6697 DN Ethopropazine hydrochloride [1094-08-2]; Down 200; 11.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.042E-3 2.699E-2
2.221E-1
1.000E0
 2 193
26 3434 UP Ergocryptine-alpha [511-09-1]; Up 200; 7uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.042E-3 2.699E-2
2.221E-1
1.000E0
 2 193
27 1830 UP Diphenhydramine hydrochloride [147-24-0]; Up 200; 13.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.042E-3 2.699E-2
2.221E-1
1.000E0
 2 193
28 CID003015906 mercury;sulfide Stitch 1.050E-3 2.699E-2
2.221E-1
1.000E0
 1 4
29 5483 DN Ornidazole [16773-42-5]; Down 200; 18.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.053E-3 2.699E-2
2.221E-1
1.000E0
 2 194
30 7493 UP ST021200; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.053E-3 2.699E-2
2.221E-1
1.000E0
 2 194
31 7098 DN 0316684-0000 [391209-55-5]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 2.699E-2
2.221E-1
1.000E0
 2 194
32 2626 UP N6-methyladenosine [1867-73-8]; Up 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.063E-3 2.699E-2
2.221E-1
1.000E0
 2 195
33 1984 UP Oxethazaine [126-27-2]; Up 200; 8.6uM; HL60; HG-U133A Broad Institute CMAP Up 1.063E-3 2.699E-2
2.221E-1
1.000E0
 2 195
34 3828 UP Flunisolide [3385-03-3]; Up 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.063E-3 2.699E-2
2.221E-1
1.000E0
 2 195
35 6887 UP SB 202190; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
36 5486 UP Tridihexethyl chloride; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
37 7408 DN Triprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
38 6141 DN Meropenem [96036-03-2]; Down 200; 10.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
39 3452 DN Methacholine chloride [62-51-1]; Down 200; 20.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
40 4538 DN Phenelzine sulfate [156-51-4]; Down 200; 17uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
41 3048 DN Propofol [2078-54-8]; Down 200; 22.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
42 2648 DN Hesperidin [520-26-3]; Down 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
43 7276 UP Disopyramide [3737-09-5]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
44 1465 DN Troleandomycin [2751-09-9]; Down 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
45 7485 DN Clemastine fumarate [14976-57-9]; Down 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
46 6469 DN Oxybenzone [131-57-7]; Down 200; 17.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.699E-2
2.221E-1
1.000E0
 2 196
47 3085 UP N-Acetyl-L-leucine [1188-21-2]; Up 200; 23uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.699E-2
2.221E-1
1.000E0
 2 197
48 3011 UP Chloropyramine hydrochloride [6170-42-9]; Up 200; 12.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.699E-2
2.221E-1
1.000E0
 2 197
49 6867 DN ICI182,780; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.085E-3 2.699E-2
2.221E-1
1.000E0
 2 197
50 6140 DN Estriol [50-27-1]; Down 200; 13.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.085E-3 2.699E-2
2.221E-1
1.000E0
 2 197
Show 45 more annotations

18: Disease [Display Chart] 4 input genes in category / 24 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0347016 Secondary malignant neoplasm of spinal cord DisGeNET BeFree 7.404E-4 1.676E-2
6.329E-2
 1.777E-2 1 3
2 C0346629 Malignant neoplasm of large intestine DisGeNET BeFree 1.480E-3 1.676E-2
6.329E-2
 3.553E-2 1 6
3 C0751691 Perineurioma DisGeNET BeFree 3.205E-3 1.676E-2
6.329E-2
7.693E-2
 1 13
4 C0024031 Low Back Pain DisGeNET Curated 4.190E-3 1.676E-2
6.329E-2
1.006E-1
 1 17
5 C3854315 Pseudoprimary hyperaldosteronism DisGeNET BeFree 4.190E-3 1.676E-2
6.329E-2
1.006E-1
 1 17
6 C0221043 Liddle Syndrome DisGeNET Curated 4.190E-3 1.676E-2
6.329E-2
1.006E-1
 1 17
7 C0346300 Pituitary carcinoma DisGeNET BeFree 5.174E-3 1.772E-2
6.693E-2
1.242E-1
 1 21
8 C1141890 Congenital long QT syndrome DisGeNET BeFree 6.894E-3 1.772E-2
6.693E-2
1.655E-1
 1 28
9 C3809250 ESTROGEN RESISTANCE DisGeNET Curated 7.140E-3 1.772E-2
6.693E-2
1.714E-1
 1 29
10 C0003431 Antisocial Personality Disorder DisGeNET Curated 7.385E-3 1.772E-2
6.693E-2
1.772E-1
 1 30
11 C1142166 Brugada Syndrome (disorder) DisGeNET Curated 1.155E-2 2.520E-2
9.517E-2
2.772E-1
 1 47
12 C0935572 Stalking (behavior) DisGeNET BeFree 1.522E-2 3.044E-2
1.149E-1
3.652E-1
 1 62
13 C0027832 Neurofibromatosis 2 DisGeNET Curated 1.692E-2 3.125E-2
1.180E-1
4.062E-1
 1 69
14 C0740391 Middle Cerebral Artery Occlusion DisGeNET BeFree 2.615E-2 4.394E-2
1.659E-1
6.277E-1
 1 107
15 C0027809 Neurilemmoma DisGeNET Curated 2.930E-2 4.394E-2
1.659E-1
7.031E-1
 1 120
16 C0027121 Myositis DisGeNET Curated 2.930E-2 4.394E-2
1.659E-1
7.031E-1
 1 120
Show 11 more annotations