Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc68_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042162 telomeric DNA binding 2.173E-10 5.432E-9 2.073E-8 5.432E-9 4 31
2 GO:0010521 telomerase inhibitor activity 1.809E-9 2.261E-8 8.627E-8 4.521E-8 3 8
3 GO:0098505 G-rich strand telomeric DNA binding 2.531E-6 2.109E-5 8.047E-5 6.327E-5 2 7
4 GO:0043047 single-stranded telomeric DNA binding 5.420E-6 3.387E-5 1.293E-4 1.355E-4 2 10
5 GO:0098847 sequence-specific single stranded DNA binding 7.946E-6 3.973E-5 1.516E-4 1.987E-4 2 12
6 GO:0004857 enzyme inhibitor activity 3.046E-4 1.269E-3 4.844E-3 7.616E-3 3 393
7 GO:0003697 single-stranded DNA binding 6.343E-4 2.265E-3 8.645E-3 1.586E-2 2 104
8 GO:0032407 MutSalpha complex binding 1.874E-3 5.622E-3 2.145E-2 4.686E-2 1 5
9 GO:0017151 DEAD/H-box RNA helicase binding 2.249E-3 5.622E-3 2.145E-2
5.622E-2
 1 6
10 GO:0032405 MutLalpha complex binding 2.249E-3 5.622E-3 2.145E-2
5.622E-2
 1 6
11 GO:0032404 mismatch repair complex binding 2.998E-3 6.245E-3 2.383E-2
7.494E-2
 1 8
12 GO:0003691 double-stranded telomeric DNA binding 2.998E-3 6.245E-3 2.383E-2
7.494E-2
 1 8
13 GO:0070182 DNA polymerase binding 4.867E-3 8.734E-3 3.333E-2
1.217E-1
 1 13
14 GO:0070034 telomerase RNA binding 5.241E-3 8.734E-3 3.333E-2
1.310E-1
 1 14
15 GO:0003720 telomerase activity 5.241E-3 8.734E-3 3.333E-2
1.310E-1
 1 14
16 GO:0008301 DNA binding, bending 7.479E-3 1.155E-2 4.406E-2
1.870E-1
 1 20
17 GO:0003964 RNA-directed DNA polymerase activity 7.852E-3 1.155E-2 4.406E-2
1.963E-1
 1 21
18 GO:0034061 DNA polymerase activity 1.750E-2 2.431E-2
9.275E-2
4.375E-1
 1 47
Show 13 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 290 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070198 protein localization to chromosome, telomeric region 3.576E-17 1.037E-14 6.480E-14 1.037E-14 6 27
2 GO:0032210 regulation of telomere maintenance via telomerase 9.831E-16 1.425E-13 8.908E-13 2.851E-13 6 45
3 GO:1904356 regulation of telomere maintenance via telomere lengthening 1.918E-15 1.854E-13 1.158E-12 5.561E-13 6 50
4 GO:0008156 negative regulation of DNA replication 3.917E-15 2.272E-13 1.420E-12 1.136E-12 6 56
5 GO:0007004 telomere maintenance via telomerase 3.917E-15 2.272E-13 1.420E-12 1.136E-12 6 56
6 GO:0034502 protein localization to chromosome 6.697E-15 3.237E-13 2.023E-12 1.942E-12 6 61
7 GO:0006278 RNA-dependent DNA biosynthetic process 9.960E-15 3.972E-13 2.482E-12 2.889E-12 6 65
8 GO:0010833 telomere maintenance via telomere lengthening 1.096E-14 3.972E-13 2.482E-12 3.177E-12 6 66
9 GO:0032204 regulation of telomere maintenance 1.320E-14 4.252E-13 2.657E-12 3.827E-12 6 68
10 GO:2000278 regulation of DNA biosynthetic process 1.349E-13 3.912E-12 2.445E-11 3.912E-11 6 99
11 GO:2000279 negative regulation of DNA biosynthetic process 2.665E-13 7.025E-12 4.390E-11 7.728E-11 5 33
12 GO:0051053 negative regulation of DNA metabolic process 3.385E-13 8.181E-12 5.112E-11 9.817E-11 6 115
13 GO:0051972 regulation of telomerase activity 1.080E-12 2.335E-11 1.459E-10 3.131E-10 5 43
14 GO:0000723 telomere maintenance 1.127E-12 2.335E-11 1.459E-10 3.269E-10 6 140
15 GO:0032200 telomere organization 1.938E-12 3.746E-11 2.341E-10 5.619E-10 6 153
16 GO:0032211 negative regulation of telomere maintenance via telomerase 3.454E-12 6.261E-11 3.912E-10 1.002E-9 4 12
17 GO:0006275 regulation of DNA replication 3.951E-12 6.740E-11 4.212E-10 1.146E-9 6 172
18 GO:0051974 negative regulation of telomerase activity 9.522E-12 1.534E-10 9.587E-10 2.761E-9 4 15
19 GO:0071897 DNA biosynthetic process 1.366E-11 2.086E-10 1.303E-9 3.963E-9 6 211
20 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 1.660E-11 2.407E-10 1.504E-9 4.814E-9 4 17
21 GO:0032205 negative regulation of telomere maintenance 1.041E-10 1.438E-9 8.987E-9 3.020E-8 4 26
22 GO:0033044 regulation of chromosome organization 1.172E-10 1.545E-9 9.652E-9 3.398E-8 6 301
23 GO:0032202 telomere assembly 1.301E-10 1.640E-9 1.025E-8 3.772E-8 3 4
24 GO:0006260 DNA replication 2.715E-10 3.281E-9 2.050E-8 7.875E-8 6 346
25 GO:0051052 regulation of DNA metabolic process 3.937E-10 4.567E-9 2.854E-8 1.142E-7 6 368
26 GO:0060249 anatomical structure homeostasis 6.702E-10 7.476E-9 4.672E-8 1.944E-7 6 402
27 GO:0032206 positive regulation of telomere maintenance 1.239E-9 1.331E-8 8.317E-8 3.594E-7 4 47
28 GO:0016233 telomere capping 1.599E-9 1.656E-8 1.035E-7 4.638E-7 4 50
29 GO:0070200 establishment of protein localization to telomere 1.477E-8 1.477E-7 9.228E-7 4.283E-6 3 15
30 GO:2001251 negative regulation of chromosome organization 5.104E-8 4.934E-7 3.083E-6 1.480E-5 4 117
31 GO:0070199 establishment of protein localization to chromosome 5.741E-8 5.370E-7 3.356E-6 1.665E-5 3 23
32 GO:1904744 positive regulation of telomeric DNA binding 1.211E-7 1.098E-6 6.858E-6 3.512E-5 2 2
33 GO:0032212 positive regulation of telomere maintenance via telomerase 1.605E-7 1.387E-6 8.667E-6 4.656E-5 3 32
34 GO:2001252 positive regulation of chromosome organization 1.626E-7 1.387E-6 8.667E-6 4.716E-5 4 156
35 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 1.766E-7 1.463E-6 9.142E-6 5.120E-5 3 33
36 GO:0097694 establishment of RNA localization to telomere 3.633E-7 2.772E-6 1.732E-5 1.053E-4 2 3
37 GO:0097695 establishment of protein-containing complex localization to telomere 3.633E-7 2.772E-6 1.732E-5 1.053E-4 2 3
38 GO:1904742 regulation of telomeric DNA binding 3.633E-7 2.772E-6 1.732E-5 1.053E-4 2 3
39 GO:0051054 positive regulation of DNA metabolic process 4.676E-7 3.477E-6 2.173E-5 1.356E-4 4 203
40 GO:2000573 positive regulation of DNA biosynthetic process 1.218E-6 8.832E-6 5.519E-5 3.533E-4 3 62
41 GO:0010639 negative regulation of organelle organization 3.532E-6 2.498E-5 1.561E-4 1.024E-3 4 337
42 GO:0045740 positive regulation of DNA replication 4.295E-6 2.966E-5 1.853E-4 1.246E-3 3 94
43 GO:0051348 negative regulation of transferase activity 5.571E-6 3.757E-5 2.348E-4 1.616E-3 4 378
44 GO:0051973 positive regulation of telomerase activity 4.557E-5 3.003E-4 1.877E-3 1.321E-2 2 28
45 GO:0000075 cell cycle checkpoint 6.604E-5 4.256E-4 2.660E-3 1.915E-2 3 234
46 GO:0043388 positive regulation of DNA binding 1.471E-4 9.273E-4 5.794E-3 4.266E-2 2 50
47 GO:0051098 regulation of binding 1.863E-4 1.150E-3 7.185E-3
5.404E-2
 3 332
48 GO:0051303 establishment of chromosome localization 2.415E-4 1.459E-3 9.116E-3
7.002E-2
 2 64
49 GO:0050000 chromosome localization 2.491E-4 1.474E-3 9.212E-3
7.223E-2
 2 65
50 GO:1904790 regulation of shelterin complex assembly 3.759E-4 1.758E-3 1.099E-2
1.090E-1
 1 1
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 44 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070187 shelterin complex 2.227E-13 9.799E-12 4.285E-11 9.799E-12 4 7
2 GO:0000784 nuclear chromosome, telomeric region 7.170E-13 1.577E-11 6.898E-11 3.155E-11 6 133
3 GO:0000781 chromosome, telomeric region 2.387E-12 3.501E-11 1.531E-10 1.050E-10 6 162
4 GO:0000782 telomere cap complex 4.546E-12 4.001E-11 1.749E-10 2.000E-10 4 13
5 GO:0000783 nuclear telomere cap complex 4.546E-12 4.001E-11 1.749E-10 2.000E-10 4 13
6 GO:0098687 chromosomal region 2.282E-10 1.673E-9 7.316E-9 1.004E-8 6 344
7 GO:0032993 protein-DNA complex 2.814E-7 1.769E-6 7.734E-6 1.238E-5 4 183
8 GO:0010370 perinucleolar chromocenter 7.344E-4 4.039E-3 1.766E-2 3.231E-2 1 2
9 GO:0000125 PCAF complex 2.202E-3 1.076E-2 4.707E-2
9.688E-2
 1 6
10 GO:0000812 Swr1 complex 3.301E-3 1.452E-2
6.351E-2
1.452E-1
 1 9
11 GO:0033276 transcription factor TFTC complex 5.131E-3 1.701E-2
7.437E-2
2.258E-1
 1 14
12 GO:0030914 STAGA complex 5.131E-3 1.701E-2
7.437E-2
2.258E-1
 1 14
13 GO:0005819 spindle 5.180E-3 1.701E-2
7.437E-2
2.279E-1
 2 308
14 GO:0001741 XY body 6.227E-3 1.701E-2
7.437E-2
2.740E-1
 1 17
15 GO:0010369 chromocenter 6.227E-3 1.701E-2
7.437E-2
2.740E-1
 1 17
16 GO:1902562 H4 histone acetyltransferase complex 6.958E-3 1.701E-2
7.437E-2
3.061E-1
 1 19
17 GO:0035267 NuA4 histone acetyltransferase complex 6.958E-3 1.701E-2
7.437E-2
3.061E-1
 1 19
18 GO:0043189 H4/H2A histone acetyltransferase complex 6.958E-3 1.701E-2
7.437E-2
3.061E-1
 1 19
19 GO:0097346 INO80-type complex 7.688E-3 1.780E-2
7.785E-2
3.383E-1
 1 21
20 GO:0000803 sex chromosome 1.169E-2 2.573E-2
1.125E-1
5.146E-1
 1 32
21 GO:0070461 SAGA-type complex 1.242E-2 2.603E-2
1.138E-1
5.465E-1
 1 34
Show 16 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 409 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001888 Lymphopenia 2.234E-5 3.897E-3 2.569E-2 9.137E-3 4 325
2 HP:0012140 Abnormality of cells of the lymphoid lineage 2.554E-5 3.897E-3 2.569E-2 1.044E-2 4 336
3 HP:0001882 Leukopenia 4.841E-5 3.897E-3 2.569E-2 1.980E-2 4 394
4 HP:0007495 Prematurely aged appearance 6.347E-5 3.897E-3 2.569E-2 2.596E-2 3 120
5 HP:0002209 Sparse scalp hair 6.670E-5 3.897E-3 2.569E-2 2.728E-2 3 122
6 HP:0002556 Thin scalp hair 6.670E-5 3.897E-3 2.569E-2 2.728E-2 3 122
7 HP:0002237 Thin hair 6.670E-5 3.897E-3 2.569E-2 2.728E-2 3 122
8 HP:0002894 Neoplasm of the pancreas 8.260E-5 4.223E-3 2.784E-2 3.378E-2 3 131
9 HP:0001807 Ridged nail 1.132E-4 4.871E-3 3.211E-2 4.628E-2 2 21
10 HP:0000958 Dry skin 1.191E-4 4.871E-3 3.211E-2 4.871E-2 3 148
11 HP:0001876 Pancytopenia 2.034E-4 6.874E-3 4.531E-2
8.320E-2
 3 177
12 HP:0003653 Cellular metachromasia 2.104E-4 6.874E-3 4.531E-2
8.604E-2
 3 179
13 HP:0012145 Abnormality of multiple cell lineages in the bone marrow 2.634E-4 6.874E-3 4.531E-2
1.077E-1
 3 193
14 HP:0011020 Abnormality of mucopolysaccharide metabolism 2.886E-4 6.874E-3 4.531E-2
1.180E-1
 3 199
15 HP:0004371 Abnormality of glycosaminoglycan metabolism 2.886E-4 6.874E-3 4.531E-2
1.180E-1
 3 199
16 HP:0002164 Nail dysplasia 2.886E-4 6.874E-3 4.531E-2
1.180E-1
 3 199
17 HP:0011012 Abnormality of polysaccharide metabolism 2.929E-4 6.874E-3 4.531E-2
1.198E-1
 3 200
18 HP:0010450 Esophageal stenosis 3.193E-4 6.874E-3 4.531E-2
1.306E-1
 2 35
19 HP:0002043 Esophageal stricture 3.193E-4 6.874E-3 4.531E-2
1.306E-1
 2 35
20 HP:0100013 Neoplasm of the breast 3.945E-4 7.736E-3
5.100E-2
1.613E-1
 3 221
21 HP:0007392 Excessive wrinkled skin 3.972E-4 7.736E-3
5.100E-2
1.625E-1
 2 39
22 HP:0007440 Generalized hyperpigmentation 5.064E-4 9.092E-3
5.994E-2
2.071E-1
 2 44
23 HP:0010719 Abnormality of hair texture 5.231E-4 9.092E-3
5.994E-2
2.140E-1
 3 243
24 HP:0002216 Premature graying of hair 5.537E-4 9.092E-3
5.994E-2
2.265E-1
 2 46
25 HP:0001009 Telangiectasia 5.558E-4 9.092E-3
5.994E-2
2.273E-1
 3 248
26 HP:0002745 Oral leukoplakia 6.031E-4 9.136E-3
6.023E-2
2.467E-1
 2 48
27 HP:0025125 White lesion of the oral mucosa 6.031E-4 9.136E-3
6.023E-2
2.467E-1
 2 48
28 HP:0100037 Abnormality of the scalp hair 7.074E-4 1.022E-2
6.739E-2
2.893E-1
 3 269
29 HP:0001965 Abnormality of the scalp 7.634E-4 1.022E-2
6.739E-2
3.122E-1
 3 276
30 HP:0100678 Premature skin wrinkling 7.638E-4 1.022E-2
6.739E-2
3.124E-1
 2 54
31 HP:0000488 Retinopathy 8.396E-4 1.022E-2
6.739E-2
3.434E-1
 3 285
32 HP:0007048 Large basal ganglia 8.498E-4 1.022E-2
6.739E-2
3.476E-1
 1 1
33 HP:0006442 Hypoplasia of proximal fibula 8.498E-4 1.022E-2
6.739E-2
3.476E-1
 1 1
34 HP:0007617 Fine, reticulate skin pigmentation 8.498E-4 1.022E-2
6.739E-2
3.476E-1
 1 1
35 HP:0001480 Freckling 8.813E-4 1.030E-2
6.789E-2
3.605E-1
 2 58
36 HP:0008070 Sparse hair 9.773E-4 1.110E-2
7.320E-2
3.997E-1
 3 300
37 HP:0011357 Abnormality of hair density 1.067E-3 1.179E-2
7.773E-2
4.363E-1
 3 309
38 HP:0011358 Generalized hypopigmentation of hair 1.434E-3 1.543E-2
1.017E-1
5.863E-1
 2 74
39 HP:0001597 Abnormality of the nail 1.620E-3 1.699E-2
1.120E-1
6.628E-1
 3 356
40 HP:0006434 Hypoplasia of proximal radius 1.699E-3 1.737E-2
1.145E-1
6.949E-1
 1 2
41 HP:0005528 Bone marrow hypocellularity 1.933E-3 1.928E-2
1.271E-1
7.907E-1
 2 86
42 HP:0004334 Dermal atrophy 2.258E-3 2.199E-2
1.450E-1
9.236E-1
 2 93
43 HP:0001732 Abnormality of the pancreas 2.317E-3 2.204E-2
1.453E-1
9.478E-1
 3 402
44 HP:0001915 Aplastic anemia 2.405E-3 2.236E-2
1.474E-1
9.836E-1
 2 96
45 HP:0001515 Prenatal growth deficiency 2.843E-3 2.528E-2
1.666E-1
1.000E0
 3 431
46 HP:0001511 Intrauterine growth retardation 2.843E-3 2.528E-2
1.666E-1
1.000E0
 3 431
47 HP:0031093 Abnormal breast morphology 3.082E-3 2.682E-2
1.768E-1
1.000E0
 3 443
48 HP:0000769 Abnormality of the breast 3.164E-3 2.696E-2
1.777E-1
1.000E0
 3 447
49 HP:0002721 Immunodeficiency 3.485E-3 2.909E-2
1.918E-1
1.000E0
 3 462
50 HP:0002115 Sparse or absent hair 3.597E-3 2.942E-2
1.939E-1
1.000E0
 3 467
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 7 input genes in category / 353 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003155 abnormal telomere length 2.075E-12 7.323E-10 4.720E-9 7.323E-10 5 28
2 MP:0010207 abnormal telomere morphology 1.213E-11 2.141E-9 1.380E-8 4.283E-9 5 39
3 MP:0003702 abnormal chromosome morphology 5.032E-10 5.921E-8 3.816E-7 1.776E-7 5 80
4 MP:0003111 abnormal cell nucleus morphology 4.353E-8 3.841E-6 2.476E-5 1.536E-5 5 193
5 MP:0030926 increased skin pigmentation 1.175E-6 8.294E-5 5.346E-4 4.147E-4 2 3
6 MP:0008008 early cellular replicative senescence 1.251E-5 7.283E-4 4.694E-3 4.416E-3 3 75
7 MP:0011096 embryonic lethality between implantation and somite formation, complete penetrance 1.444E-5 7.283E-4 4.694E-3 5.098E-3 4 268
8 MP:0008007 abnormal cellular replicative senescence 2.025E-5 8.618E-4 5.555E-3 7.150E-3 3 88
9 MP:0006205 embryonic lethality between implantation and somite formation 2.197E-5 8.618E-4 5.555E-3 7.756E-3 4 298
10 MP:0000648 absent sebaceous gland 2.577E-5 9.097E-4 5.863E-3 9.097E-3 2 12
11 MP:0013543 abnormal holocrine gland morphology 3.346E-5 9.841E-4 6.343E-3 1.181E-2 3 104
12 MP:0000647 abnormal sebaceous gland morphology 3.346E-5 9.841E-4 6.343E-3 1.181E-2 3 104
13 MP:0000378 absent hair follicles 4.096E-5 1.112E-3 7.168E-3 1.446E-2 2 15
14 MP:0008866 chromosomal instability 5.009E-5 1.239E-3 7.985E-3 1.768E-2 3 119
15 MP:0010094 abnormal chromosome stability 5.264E-5 1.239E-3 7.985E-3 1.858E-2 3 121
16 MP:0003745 abnormal oral mucosa morphology 5.963E-5 1.316E-3 8.479E-3 2.105E-2 2 18
17 MP:0004964 absent inner cell mass 8.176E-5 1.603E-3 1.033E-2 2.886E-2 2 21
18 MP:0030927 decreased telomere length 8.176E-5 1.603E-3 1.033E-2 2.886E-2 2 21
19 MP:0013818 abnormal oral cavity morphology 1.074E-4 1.908E-3 1.230E-2 3.790E-2 2 24
20 MP:0009850 embryonic lethality between implantation and placentation 1.081E-4 1.908E-3 1.230E-2 3.816E-2 4 447
21 MP:0004046 abnormal mitosis 1.145E-4 1.924E-3 1.240E-2 4.040E-2 3 157
22 MP:0005152 pancytopenia 1.924E-4 3.088E-3 1.990E-2
6.793E-2
 2 32
23 MP:0001188 hyperpigmentation 2.306E-4 3.539E-3 2.281E-2
8.141E-2
 2 35
24 MP:0014137 abnormal preimplantation embryo morphology 2.634E-4 3.720E-3 2.397E-2
9.300E-2
 3 208
25 MP:0004957 abnormal blastocyst morphology 2.634E-4 3.720E-3 2.397E-2
9.300E-2
 3 208
26 MP:0000377 abnormal hair follicle morphology 4.017E-4 5.454E-3 3.515E-2
1.418E-1
 3 240
27 MP:0030572 abnormal pilosebaceous unit morphology 7.578E-4 9.908E-3
6.386E-2
2.675E-1
 3 298
28 MP:0004028 chromosome breakage 9.789E-4 1.234E-2
7.954E-2
3.456E-1
 2 72
29 MP:0003077 abnormal cell cycle 1.039E-3 1.264E-2
8.147E-2
3.666E-1
 3 332
30 MP:0002718 abnormal inner cell mass morphology 1.268E-3 1.352E-2
8.713E-2
4.475E-1
 2 82
31 MP:0003704 abnormal hair follicle development 1.299E-3 1.352E-2
8.713E-2
4.584E-1
 2 83
32 MP:0001711 abnormal placenta morphology 1.335E-3 1.352E-2
8.713E-2
4.714E-1
 3 362
33 MP:0005501 abnormal skin physiology 1.346E-3 1.352E-2
8.713E-2
4.752E-1
 3 363
34 MP:0030048 sloping forehead 1.352E-3 1.352E-2
8.713E-2
4.771E-1
 1 2
35 MP:0030004 hippocampus hypoplasia 1.352E-3 1.352E-2
8.713E-2
4.771E-1
 1 2
36 MP:0001216 abnormal epidermal layer morphology 1.379E-3 1.352E-2
8.713E-2
4.867E-1
 3 366
37 MP:0002796 impaired skin barrier function 1.559E-3 1.487E-2
9.585E-2
5.502E-1
 2 91
38 MP:0003751 oral leukoplakia 2.027E-3 1.883E-2
1.213E-1
7.155E-1
 1 3
39 MP:0011101 prenatal lethality, incomplete penetrance 2.301E-3 2.083E-2
1.342E-1
8.122E-1
 3 437
40 MP:0002095 abnormal skin pigmentation 2.434E-3 2.148E-2
1.384E-1
8.591E-1
 2 114
41 MP:0010344 increased hibernoma incidence 2.702E-3 2.271E-2
1.463E-1
9.537E-1
 1 4
42 MP:0013538 increased Harderian gland adenoma incidence 2.702E-3 2.271E-2
1.463E-1
9.537E-1
 1 4
43 MP:0011239 abnormal skin coloration 2.782E-3 2.283E-2
1.472E-1
9.819E-1
 2 122
44 MP:0005028 abnormal trophectoderm morphology 2.872E-3 2.304E-2
1.485E-1
1.000E0
 2 124
45 MP:0001186 pigmentation phenotype 3.140E-3 2.463E-2
1.587E-1
1.000E0
 3 487
46 MP:0012525 abnormal rhombic lip morphology 3.376E-3 2.591E-2
1.670E-1
1.000E0
 1 5
47 MP:0011203 abnormal parietal yolk sac morphology 3.800E-3 2.854E-2
1.840E-1
1.000E0
 2 143
48 MP:0030928 increased telomere length 4.050E-3 2.859E-2
1.843E-1
1.000E0
 1 6
49 MP:0000640 adrenal gland hypoplasia 4.050E-3 2.859E-2
1.843E-1
1.000E0
 1 6
50 MP:0008404 increased cellular sensitivity to methylmethanesulfonate 4.050E-3 2.859E-2
1.843E-1
1.000E0
 1 6
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 57 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF02259 FAT Pfam 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
2 IPR003152 FATC dom InterPro 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
3 PS51189 FAT PROSITE 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
4 IPR003151 PIK-rel kinase FAT InterPro 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
5 IPR014009 PIK FAT InterPro 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
6 PS51190 FATC PROSITE 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
7 SM01343 FATC SMART 1.794E-6 1.461E-5 6.761E-5 1.022E-4 2 6
8 1.10.1070.11 - Gene3D 1.432E-5 7.433E-5 3.441E-4 8.165E-4 2 16
9 SM00146 PI3Kc SMART 1.432E-5 7.433E-5 3.441E-4 8.165E-4 2 16
10 PS50290 PI3 4 KINASE 3 PROSITE 1.826E-5 7.433E-5 3.441E-4 1.041E-3 2 18
11 PS00915 PI3 4 KINASE 1 PROSITE 1.826E-5 7.433E-5 3.441E-4 1.041E-3 2 18
12 PS00916 PI3 4 KINASE 2 PROSITE 1.826E-5 7.433E-5 3.441E-4 1.041E-3 2 18
13 PF00454 PI3 PI4 kinase Pfam 1.826E-5 7.433E-5 3.441E-4 1.041E-3 2 18
14 IPR000403 PI3/4 kinase cat dom InterPro 1.826E-5 7.433E-5 3.441E-4 1.041E-3 2 18
15 SM00802 UME SMART 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
16 IPR029400 TINF2 N InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
17 PF16686 POT1PC Pfam 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
18 IPR012993 UME InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
19 IPR032042 POT1PC InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
20 PF14973 TINF2 N Pfam 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
21 IPR011564 Telomer end-bd POT1/Cdc13 InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
22 SM00976 Telo bind SMART 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
23 IPR028631 ACD InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
24 IPR028389 POT1 InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
25 IPR033317 TRA1/TRRAP InterPro 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
26 PF08064 UME Pfam 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
27 PF02765 POT1 Pfam 3.736E-4 7.888E-4 3.651E-3 2.130E-2 1 1
28 1.25.40.210 - Gene3D 7.471E-4 1.331E-3 6.161E-3 4.259E-2 1 2
29 IPR017357 TERF1 InterPro 7.471E-4 1.331E-3 6.161E-3 4.259E-2 1 2
30 PD014243 Telomere repeat-bd fac dimer ProDom 7.471E-4 1.331E-3 6.161E-3 4.259E-2 1 2
31 IPR013867 Telomere rpt-bd fac dimer dom InterPro 7.471E-4 1.331E-3 6.161E-3 4.259E-2 1 2
32 PF08558 TRF Pfam 7.471E-4 1.331E-3 6.161E-3 4.259E-2 1 2
33 PF02260 FATC Pfam 1.867E-3 3.225E-3 1.493E-2
1.064E-1
 1 5
34 1.25.40.10 - Gene3D 2.483E-3 4.163E-3 1.927E-2
1.415E-1
 2 208
35 1.25.10.10 - Gene3D 2.823E-3 4.597E-3 2.128E-2
1.609E-1
 2 222
36 IPR011990 TPR-like helical dom InterPro 3.130E-3 4.956E-3 2.294E-2
1.784E-1
 2 234
37 IPR017930 Myb dom InterPro 3.358E-3 5.038E-3 2.332E-2
1.914E-1
 1 9
38 PS51294 HTH MYB PROSITE 3.358E-3 5.038E-3 2.332E-2
1.914E-1
 1 9
39 IPR011989 ARM-like InterPro 4.173E-3 6.099E-3 2.823E-2
2.379E-1
 2 271
40 IPR018936 PI3/4 kinase CS InterPro 5.592E-3 7.969E-3 3.689E-2
3.187E-1
 1 15
41 IPR009050 Globin-like InterPro 5.964E-3 8.291E-3 3.838E-2
3.399E-1
 1 16
42 IPR021133 HEAT type 2 InterPro 6.335E-3 8.598E-3 3.980E-2
3.611E-1
 1 17
43 IPR016024 ARM-type fold InterPro 6.493E-3 8.606E-3 3.984E-2
3.701E-1
 2 340
44 SM00443 G patch SMART 8.563E-3 1.039E-2 4.807E-2
4.881E-1
 1 23
45 PF01585 G-patch Pfam 8.563E-3 1.039E-2 4.807E-2
4.881E-1
 1 23
46 PS50174 G PATCH PROSITE 8.563E-3 1.039E-2 4.807E-2
4.881E-1
 1 23
47 IPR000467 G patch dom InterPro 8.563E-3 1.039E-2 4.807E-2
4.881E-1
 1 23
48 PF00249 Myb DNA-binding Pfam 1.301E-2 1.544E-2
7.149E-2
7.413E-1
 1 35
49 PS50090 MYB LIKE PROSITE 1.411E-2 1.642E-2
7.600E-2
8.045E-1
 1 38
50 PF02985 HEAT Pfam 1.780E-2 2.029E-2
9.393E-2
1.000E0
 1 48
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 57 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 7.474E-11 4.260E-9 1.972E-8 4.260E-9 5 66
2 1269867 Meiotic synapsis BioSystems: REACTOME 2.007E-10 5.719E-9 2.647E-8 1.144E-8 5 80
3 1269865 Meiosis BioSystems: REACTOME 1.720E-9 3.269E-8 1.513E-7 9.807E-8 5 122
4 1269864 Packaging Of Telomere Ends BioSystems: REACTOME 9.382E-9 1.337E-7 6.189E-7 5.348E-7 4 52
5 1270429 DNA Damage/Telomere Stress Induced Senescence BioSystems: REACTOME 5.452E-8 6.014E-7 2.784E-6 3.107E-6 4 80
6 1269856 Telomere Maintenance BioSystems: REACTOME 6.330E-8 6.014E-7 2.784E-6 3.608E-6 4 83
7 1269853 Chromosome Maintenance BioSystems: REACTOME 1.978E-7 1.611E-6 7.457E-6 1.128E-5 4 110
8 1270414 Cellular responses to stress BioSystems: REACTOME 1.247E-6 8.886E-6 4.113E-5 7.108E-5 5 454
9 1270426 Cellular Senescence BioSystems: REACTOME 2.051E-6 1.299E-5 6.012E-5 1.169E-4 4 197
10 137978 Circadian rhythm pathway BioSystems: Pathway Interaction Database 7.847E-3 3.993E-2
1.848E-1
4.473E-1
 1 14
11 373901 HTLV-I infection BioSystems: KEGG 8.261E-3 3.993E-2
1.848E-1
4.709E-1
 2 256
12 M8516 Multi-step Regulation of Transcription by Pitx2 MSigDB C2 BIOCARTA (v6.0) 8.405E-3 3.993E-2
1.848E-1
4.791E-1
 1 15
13 M10401 Telomeres, Telomerase, Cellular Aging, and Immortality MSigDB C2 BIOCARTA (v6.0) 1.008E-2 4.419E-2
2.046E-1
5.745E-1
 1 18
14 M9703 Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility MSigDB C2 BIOCARTA (v6.0) 1.175E-2 4.677E-2
2.165E-1
6.698E-1
 1 21
15 169344 C-MYC pathway BioSystems: Pathway Interaction Database 1.231E-2 4.677E-2
2.165E-1
7.015E-1
 1 22
16 M8560 Cell Cycle: G2/M Checkpoint MSigDB C2 BIOCARTA (v6.0) 1.342E-2 4.781E-2
2.213E-1
7.649E-1
 1 24
Show 11 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1088 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15231715 POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Pubmed 3.948E-16 4.296E-13 3.252E-12 4.296E-13 4 4
2 24469404 TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Pubmed 1.974E-15 1.074E-12 8.128E-12 2.148E-12 4 5
3 15181449 PTOP interacts with POT1 and regulates its localization to telomeres. Pubmed 5.922E-15 1.074E-12 8.128E-12 6.443E-12 4 6
4 16880378 A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Pubmed 5.922E-15 1.074E-12 8.128E-12 6.443E-12 4 6
5 21209389 How shelterin solves the telomere end-protection problem. Pubmed 5.922E-15 1.074E-12 8.128E-12 6.443E-12 4 6
6 21852327 Characterization of the DNA binding specificity of Shelterin complexes. Pubmed 5.922E-15 1.074E-12 8.128E-12 6.443E-12 4 6
7 15316005 TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. Pubmed 2.763E-14 3.758E-12 2.845E-11 3.006E-11 4 8
8 16166375 Shelterin: the protein complex that shapes and safeguards human telomeres. Pubmed 2.763E-14 3.758E-12 2.845E-11 3.006E-11 4 8
9 15383534 Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. Pubmed 1.302E-13 1.574E-11 1.192E-10 1.417E-10 4 11
10 23685356 HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Pubmed 5.386E-13 5.860E-11 4.436E-10 5.860E-10 4 15
11 15380063 A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Pubmed 3.770E-12 3.155E-10 2.388E-9 4.101E-9 3 3
12 28643740 Telomere length variation and expression analysis of shelterin complex genes during gallbladder carcinogenesis. Pubmed 3.770E-12 3.155E-10 2.388E-9 4.101E-9 3 3
13 14715659 DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. Pubmed 3.770E-12 3.155E-10 2.388E-9 4.101E-9 3 3
14 26586433 ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Pubmed 1.508E-11 1.172E-9 8.870E-9 1.640E-8 3 4
15 24270157 A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Pubmed 1.828E-11 1.326E-9 1.003E-8 1.988E-8 4 34
16 18202258 A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Pubmed 3.769E-11 2.412E-9 1.826E-8 4.101E-8 3 5
17 25589350 Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Pubmed 3.769E-11 2.412E-9 1.826E-8 4.101E-8 3 5
18 25620558 TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding. Pubmed 7.538E-11 3.566E-9 2.699E-8 8.201E-8 3 6
19 11701125 The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Pubmed 7.538E-11 3.566E-9 2.699E-8 8.201E-8 3 6
20 22099311 Telomere protection by TPP1/POT1 requires tethering to TIN2. Pubmed 7.538E-11 3.566E-9 2.699E-8 8.201E-8 3 6
21 12768206 POT1 as a terminal transducer of TRF1 telomere length control. Pubmed 7.538E-11 3.566E-9 2.699E-8 8.201E-8 3 6
22 17053789 POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. Pubmed 7.538E-11 3.566E-9 2.699E-8 8.201E-8 3 6
23 25344324 TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Pubmed 7.538E-11 3.566E-9 2.699E-8 8.201E-8 3 6
24 25172512 The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7. Pubmed 2.110E-10 9.566E-9 7.241E-8 2.296E-7 3 8
25 18160036 Tel2 regulates the stability of PI3K-related protein kinases. Pubmed 3.165E-10 1.275E-8 9.654E-8 3.444E-7 3 9
26 19766477 Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. Pubmed 3.165E-10 1.275E-8 9.654E-8 3.444E-7 3 9
27 20056641 Multiple genetic variants in telomere pathway genes and breast cancer risk. Pubmed 3.165E-10 1.275E-8 9.654E-8 3.444E-7 3 9
28 19135898 Purification of proteins associated with specific genomic Loci. Pubmed 5.043E-10 1.959E-8 1.483E-7 5.486E-7 4 76
29 20937264 Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. Pubmed 6.216E-10 2.332E-8 1.765E-7 6.763E-7 3 11
30 21044950 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Pubmed 9.673E-10 3.508E-8 2.656E-7 1.052E-6 5 330
31 17632522 Telomere protection by mammalian Pot1 requires interaction with Tpp1. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
32 28393832 Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
33 21461822 Human telomere POT1-TPP1 complex and its role in telomerase activity regulation. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
34 23616058 Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
35 21355086 Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
36 17237768 The POT1-TPP1 telomere complex is a telomerase processivity factor. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
37 19424630 Increased expression of telomere-related proteins correlates with resistance to radiation in human laryngeal cancer cell lines. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
38 26365187 Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
39 28393830 Structural and functional analysis of the human POT1-TPP1 telomeric complex. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
40 24516170 G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
41 27173378 POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
42 19265708 Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
43 12676566 Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
44 20094033 POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
45 26135248 Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
46 22331467 PinX1 localizes to telomeres and stabilizes TRF1 at mitosis. Pubmed 2.879E-8 6.810E-7 5.155E-6 3.133E-5 2 2
47 10581025 TIN2, a new regulator of telomere length in human cells. Pubmed 8.637E-8 1.566E-6 1.186E-5 9.397E-5 2 3
48 22336916 Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro. Pubmed 8.637E-8 1.566E-6 1.186E-5 9.397E-5 2 3
49 25263700 Single-molecule real-time detection of telomerase extension activity. Pubmed 8.637E-8 1.566E-6 1.186E-5 9.397E-5 2 3
50 18178559 Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. Pubmed 8.637E-8 1.566E-6 1.186E-5 9.397E-5 2 3
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 716 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ZNF790 ZNF790 interactions 4.277E-14 3.062E-11 2.190E-10 3.062E-11 4 5
2 int:PAGE2 PAGE2 interactions 1.283E-13 4.593E-11 3.285E-10 9.186E-11 4 6
3 int:AFAP1L2 AFAP1L2 interactions 2.821E-12 6.732E-10 4.814E-9 2.020E-9 4 11
4 int:SULT1C2 SULT1C2 interactions 4.230E-12 7.572E-10 5.415E-9 3.029E-9 4 12
5 int:PGM2 PGM2 interactions 1.166E-11 1.670E-9 1.194E-8 8.349E-9 4 15
6 int:ZFP36L1 ZFP36L1 interactions 3.309E-11 3.949E-9 2.824E-8 2.369E-8 4 19
7 int:TRIM16 TRIM16 interactions 2.025E-10 2.071E-8 1.481E-7 1.450E-7 4 29
8 int:HNMT HNMT interactions 1.324E-9 1.185E-7 8.475E-7 9.481E-7 3 7
9 int:TOMM34 TOMM34 interactions 1.517E-9 1.207E-7 8.632E-7 1.086E-6 4 47
10 int:BIN2 BIN2 interactions 2.118E-9 1.498E-7 1.071E-6 1.517E-6 3 8
11 int:NUDCD2 NUDCD2 interactions 2.301E-9 1.498E-7 1.071E-6 1.648E-6 4 52
12 int:DCX DCX interactions 2.687E-9 1.603E-7 1.147E-6 1.924E-6 4 54
13 int:ANXA8L1 ANXA8L1 interactions 3.177E-9 1.750E-7 1.251E-6 2.275E-6 3 9
14 int:ACD ACD interactions 7.331E-9 3.749E-7 2.681E-6 5.249E-6 4 69
15 int:HOXA3 HOXA3 interactions 8.316E-9 3.969E-7 2.839E-6 5.954E-6 3 12
16 int:DCLRE1B DCLRE1B interactions 2.115E-8 8.989E-7 6.428E-6 1.515E-5 3 16
17 int:ENO2 ENO2 interactions 2.161E-8 8.989E-7 6.428E-6 1.547E-5 4 90
18 int:PFKP PFKP interactions 2.260E-8 8.989E-7 6.428E-6 1.618E-5 4 91
19 int:CKB CKB interactions 2.690E-8 1.014E-6 7.250E-6 1.926E-5 4 95
20 int:EIF4B EIF4B interactions 2.927E-8 1.048E-6 7.494E-6 2.096E-5 4 97
21 int:TERT TERT interactions 3.179E-8 1.084E-6 7.752E-6 2.276E-5 4 99
22 int:TERF1 TERF1 interactions 3.638E-8 1.162E-6 8.309E-6 2.605E-5 5 317
23 int:LASP1 LASP1 interactions 3.732E-8 1.162E-6 8.309E-6 2.672E-5 4 103
24 int:TINF2 TINF2 interactions 5.624E-8 1.600E-6 1.145E-5 4.027E-5 4 114
25 int:AIPL1 AIPL1 interactions 5.811E-8 1.600E-6 1.145E-5 4.161E-5 3 22
26 int:GNMT GNMT interactions 5.811E-8 1.600E-6 1.145E-5 4.161E-5 3 22
27 int:CCDC9 CCDC9 interactions 8.675E-8 2.218E-6 1.586E-5 6.211E-5 3 25
28 int:DPP3 DPP3 interactions 8.675E-8 2.218E-6 1.586E-5 6.211E-5 3 25
29 int:RECQL4 RECQL4 interactions 1.377E-7 3.400E-6 2.432E-5 9.861E-5 3 29
30 int:FAM131B FAM131B interactions 1.869E-7 4.460E-6 3.189E-5 1.338E-4 3 32
31 int:TERF2IP TERF2IP interactions 1.989E-7 4.595E-6 3.286E-5 1.424E-4 4 156
32 int:DPYSL3 DPYSL3 interactions 2.688E-7 6.014E-6 4.301E-5 1.925E-4 3 36
33 int:CPNE3 CPNE3 interactions 2.925E-7 6.346E-6 4.538E-5 2.094E-4 3 37
34 int:TUBB4B TUBB4B interactions 3.229E-7 6.756E-6 4.832E-5 2.312E-4 4 176
35 int:LDHA LDHA interactions 3.303E-7 6.756E-6 4.832E-5 2.365E-4 4 177
36 int:ACOT7 ACOT7 interactions 3.439E-7 6.839E-6 4.891E-5 2.462E-4 3 39
37 int:NOL3 NOL3 interactions 3.717E-7 7.003E-6 5.009E-5 2.661E-4 3 40
38 int:ANKMY2 ANKMY2 interactions 3.717E-7 7.003E-6 5.009E-5 2.661E-4 3 40
39 int:CALD1 CALD1 interactions 4.979E-7 9.141E-6 6.537E-5 3.565E-4 3 44
40 int:PGM1 PGM1 interactions 6.093E-7 1.091E-5 7.800E-5 4.363E-4 3 47
41 int:POT1 POT1 interactions 6.803E-7 1.188E-5 8.497E-5 4.871E-4 4 212
42 int:TNKS TNKS interactions 9.309E-7 1.587E-5 1.135E-4 6.665E-4 3 54
43 int:WRN WRN interactions 9.845E-7 1.602E-5 1.146E-4 7.049E-4 3 55
44 int:TAGLN TAGLN interactions 9.845E-7 1.602E-5 1.146E-4 7.049E-4 3 55
45 int:NCDN NCDN interactions 1.098E-6 1.746E-5 1.249E-4 7.859E-4 3 57
46 int:TRIP10 TRIP10 interactions 1.157E-6 1.801E-5 1.288E-4 8.286E-4 3 58
47 int:CRYGS CRYGS interactions 1.339E-6 1.943E-5 1.390E-4 9.591E-4 2 5
48 int:NXNL1 NXNL1 interactions 1.339E-6 1.943E-5 1.390E-4 9.591E-4 2 5
49 int:TBCD TBCD interactions 1.349E-6 1.943E-5 1.390E-4 9.660E-4 3 61
50 int:DBN1 DBN1 interactions 1.357E-6 1.943E-5 1.390E-4 9.716E-4 4 252
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q21.2-q22.1 7q21.2-q22.1 4.039E-4 2.827E-3 7.330E-3 2.827E-3 1 2
2 7q31.33 7q31.33 2.220E-3 7.060E-3 1.831E-2 1.554E-2 1 11
3 8p23 8p23 3.026E-3 7.060E-3 1.831E-2 2.118E-2 1 15
4 8q21.11 8q21.11 5.843E-3 1.022E-2 2.651E-2 4.090E-2 1 29
5 3q23 3q23 9.053E-3 1.267E-2 3.286E-2
6.337E-2
 1 45
6 14q12 14q12 1.126E-2 1.313E-2 3.405E-2
7.879E-2
 1 56
7 16q22.1 16q22.1 2.280E-2 2.280E-2
5.911E-2
1.596E-1
 1 114
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 8 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1334 Shelterin complex genenames.org 4.929E-14 1.972E-13 4.107E-13 1.972E-13 4 6
2 1059 SAGA complex genenames.org 5.594E-3 9.646E-3 2.010E-2 2.238E-2 1 17
3 579 G-patch domain containing|RNA binding motif containing genenames.org 7.234E-3 9.646E-3 2.010E-2 2.894E-2 1 22
4 532 GATA zinc finger domain containing|Myb/SANT domain containing genenames.org 1.735E-2 1.735E-2 3.615E-2
6.942E-2
 1 53

13: Coexpression [Display Chart] 7 input genes in category / 478 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6647 Genes up-regulated in bone marrow-derived macrophages at 45 min of stimulation by LPS: wildtype versus IL10 [GeneID=3486]. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 7.875E-3
5.314E-2
 1.038E-2 3 200
2 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.295E-5 7.875E-3
5.314E-2
 1.575E-2 3 230
3 M15383 Supplementary Table 2. Genelist comparing microarray expression profiles of spermatogonial cells, haGSCs and hES (H1) cells. Examples of expression rates of different hES cell enriched and germ cell specific genes, surface markers for germ cell selection and signal transduction in all three cell types (spermatogonial cells = SC). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.783E-5 9.214E-3
6.218E-2
 2.764E-2 2 39
4 M7899 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and tBH [PubChem=5283344;6410]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.377E-4 1.646E-2
1.111E-1
6.583E-2
 2 60
5 M15150 Genes up-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.039E-4 1.949E-2
1.315E-1
9.746E-2
 3 425
6 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.906E-4 3.112E-2
2.100E-1
1.867E-1
 2 101
7 M17193 Down-regulated genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [GeneID=23495]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.126E-3 3.627E-2
2.447E-1
5.382E-1
 2 172
8 M9014 Genes down-regulated in CD4 [GeneID=920] cells after immunization: wildtype versus CTLA4 [GeneID=1493] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.273E-3 3.627E-2
2.447E-1
6.085E-1
 2 183
9 M5210 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. major versus DCs exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 3.627E-2
2.447E-1
7.111E-1
 2 198
10 M7254 Genes up-regulated in thymus subcapsular cortical region versus the whole medulla. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.627E-2
2.447E-1
7.182E-1
 2 199
11 M1272 Genes specifically down-regulated via JNK (MAPK8) [GeneID=5599] signaling pathway activated by paclitaxel [PubChem=4666] in BR cells (ovarian cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.512E-3 3.627E-2
2.447E-1
7.227E-1
 1 5
12 M5076 Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and high dose methotrexate (HDMTX) [PubChem=4112]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.512E-3 3.627E-2
2.447E-1
7.227E-1
 1 5
13 M6049 Genes up-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by TGFB1 [GeneID=7040] and IL-12 (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
14 M5086 Genes down-regulated in comparison of memory CD8 T cells versus those treated with IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
15 M3132 Genes down-regulated in comparison of untreated macrophages versus those cultured with M-CSF [GeneID=1435], IFNG [GeneID=3458] and Pam3Cys (TLR2 agonist). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
16 M7789 Genes up-regulated in neutrophils: untreated versus stimulated by CSF2 and IFNG [GeneID=1437;3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
17 M7530 Genes up-regulated in stimulated by anti-CD3 double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
18 M9847 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
19 M9327 Genes down-regulated in marginal zone B cells versus day 40 memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
20 M8072 Genes up-regulated in thymic implants from fetal liver versus those from adult bone marrow. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.627E-2
2.447E-1
7.253E-1
 2 200
21 M12434 Genes involved in cell cycle regulation which were up-regulated in MCF-7 cells (breast cancer) by tretinoin (retinoic acid) [PubChem=444795]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.814E-3 4.129E-2
2.786E-1
8.671E-1
 1 6
Show 16 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 213 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e12.5 M GermCellTestis Oct 500 dev gonad e12.5 M GermCellTestis Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.835E-4 2.092E-2
1.243E-1
 3.909E-2 3 387
2 gudmap dev gonad e13.5 M GermCell Oct 500 dev gonad e13.5 M GermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.964E-4 2.092E-2
1.243E-1
 4.184E-2 3 396

15: Computational [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3665 MORF CDC10 Neighborhood of CDC10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.960E-3 4.899E-2
1.870E-1
 4.899E-2 2 143

16: MicroRNA [Display Chart] 7 input genes in category / 105 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-331-3p:mirSVR highEffct hsa-miR-331-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.170E-4 1.781E-2
9.323E-2
 3.328E-2 2 283
2 hsa-miR-718:mirSVR lowEffct hsa-miR-718:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.948E-4 1.781E-2
9.323E-2
 4.145E-2 2 316
3 hsa-miR-185-5p:Functional MTI Functional MTI miRTarbase 5.087E-4 1.781E-2
9.323E-2
5.342E-2
 2 359
4 hsa-miR-6506-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.750E-4 2.034E-2
1.065E-1
8.137E-2
 1 8
5 hsa-miR-4999-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.580E-3 4.355E-2
2.281E-1
3.759E-1
 1 37
6 hsa-miR-99b:mirSVR highEffct hsa-miR-99b:mirSVR conserved highEffect-0.5 MicroRNA.org 4.449E-3 4.355E-2
2.281E-1
4.671E-1
 1 46
7 hsa-miR-3164:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 4.355E-2
2.281E-1
6.090E-1
 1 60
8 hsa-miR-4501:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 4.355E-2
2.281E-1
6.191E-1
 1 61
9 hsa-miR-6820-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 4.355E-2
2.281E-1
6.191E-1
 1 61
10 hsa-miR-642b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.355E-2
2.281E-1
8.315E-1
 1 82
11 hsa-miR-642a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.355E-2
2.281E-1
8.315E-1
 1 82
12 hsa-miR-3118:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 4.355E-2
2.281E-1
8.517E-1
 1 84
13 hsa-miR-346:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.881E-3 4.355E-2
2.281E-1
9.325E-1
 1 92
14 hsa-miR-933:mirSVR highEffct hsa-miR-933:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.362E-3 4.355E-2
2.281E-1
9.830E-1
 1 97
15 hsa-miR-8066:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.458E-3 4.355E-2
2.281E-1
9.931E-1
 1 98
16 hsa-miR-6128:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.458E-3 4.355E-2
2.281E-1
9.931E-1
 1 98
17 hsa-miR-5683:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.650E-3 4.355E-2
2.281E-1
1.000E0
 1 100
18 hsa-miR-4281:mirSVR highEffct hsa-miR-4281:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.650E-3 4.355E-2
2.281E-1
1.000E0
 1 100
19 hsa-miR-134-5p:Functional MTI Functional MTI miRTarbase 9.746E-3 4.355E-2
2.281E-1
1.000E0
 1 101
20 hsa-miR-8068:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.842E-3 4.355E-2
2.281E-1
1.000E0
 1 102
21 hsa-miR-208a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-2 4.355E-2
2.281E-1
1.000E0
 1 110
22 hsa-miR-208b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.071E-2 4.355E-2
2.281E-1
1.000E0
 1 111
23 hsa-miR-383-5p:Functional MTI Functional MTI miRTarbase 1.080E-2 4.355E-2
2.281E-1
1.000E0
 1 112
24 hsa-miR-5589-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.138E-2 4.355E-2
2.281E-1
1.000E0
 1 118
25 hsa-miR-4762-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.243E-2 4.355E-2
2.281E-1
1.000E0
 1 129
26 hsa-miR-1245:PITA hsa-miR-1245:PITA TOP PITA 1.272E-2 4.355E-2
2.281E-1
1.000E0
 1 132
27 hsa-miR-6835-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.330E-2 4.355E-2
2.281E-1
1.000E0
 1 138
28 hsa-miR-330-3p:Functional MTI Functional MTI miRTarbase 1.406E-2 4.355E-2
2.281E-1
1.000E0
 1 146
29 hsa-miR-33a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.406E-2 4.355E-2
2.281E-1
1.000E0
 1 146
30 hsa-miR-6888-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.473E-2 4.355E-2
2.281E-1
1.000E0
 1 153
31 hsa-miR-503:mirSVR highEffct hsa-miR-503:mirSVR conserved highEffect-0.5 MicroRNA.org 1.492E-2 4.355E-2
2.281E-1
1.000E0
 1 155
32 hsa-miR-3120-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.502E-2 4.355E-2
2.281E-1
1.000E0
 1 156
33 hsa-miR-3149:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.664E-2 4.355E-2
2.281E-1
1.000E0
 1 173
34 hsa-miR-2276-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.846E-2 4.355E-2
2.281E-1
1.000E0
 1 192
35 hsa-miR-760:Functional MTI Functional MTI miRTarbase 1.865E-2 4.355E-2
2.281E-1
1.000E0
 1 194
36 hsa-miR-558:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.884E-2 4.355E-2
2.281E-1
1.000E0
 1 196
37 hsa-miR-3160-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.893E-2 4.355E-2
2.281E-1
1.000E0
 1 197
38 hsa-miR-3664-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.903E-2 4.355E-2
2.281E-1
1.000E0
 1 198
39 hsa-miR-7851-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.912E-2 4.355E-2
2.281E-1
1.000E0
 1 199
40 hsa-miR-1301-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.912E-2 4.355E-2
2.281E-1
1.000E0
 1 199
41 hsa-miR-6892-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.960E-2 4.355E-2
2.281E-1
1.000E0
 1 204
42 hsa-miR-548e-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.960E-2 4.355E-2
2.281E-1
1.000E0
 1 204
43 hsa-miR-196a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.970E-2 4.355E-2
2.281E-1
1.000E0
 1 205
44 hsa-miR-1229-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.989E-2 4.355E-2
2.281E-1
1.000E0
 1 207
45 hsa-miR-490-3p:Functional MTI Functional MTI miRTarbase 2.055E-2 4.355E-2
2.281E-1
1.000E0
 1 214
46 hsa-miR-4487:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.112E-2 4.355E-2
2.281E-1
1.000E0
 1 220
47 hsa-miR-642a-5p:Functional MTI Functional MTI miRTarbase 2.151E-2 4.355E-2
2.281E-1
1.000E0
 1 224
48 hsa-miR-31-5p:Functional MTI Functional MTI miRTarbase 2.151E-2 4.355E-2
2.281E-1
1.000E0
 1 224
49 hsa-miR-6881-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.170E-2 4.355E-2
2.281E-1
1.000E0
 1 226
50 hsa-miR-4659a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.208E-2 4.355E-2
2.281E-1
1.000E0
 1 230
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 980 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000006199 psoralen Stitch 5.906E-9 5.788E-6 4.321E-5 5.788E-6 4 84
2 CID000006278 1,1,1-trichloroethane Stitch 7.212E-8 3.534E-5 2.638E-4 7.067E-5 4 156
3 CID000073670 clofentezine Stitch 1.733E-7 5.661E-5 4.226E-4 1.698E-4 3 40
4 CID000099462 GITC Stitch 1.093E-5 2.677E-3 1.998E-2 1.071E-2 2 17
5 1758 UP Harmine hydrochloride [343-27-1]; Up 200; 16uM; HL60; HG-U133A Broad Institute CMAP Up 2.156E-5 3.575E-3 2.669E-2 2.113E-2 3 197
6 1940 DN Dehydrocholic acid [81-23-2]; Down 200; 9.6uM; PC3; HG-U133A Broad Institute CMAP Down 2.189E-5 3.575E-3 2.669E-2 2.145E-2 3 198
7 CID000148163 ACDDP Stitch 3.065E-4 2.383E-2
1.779E-1
3.003E-1
 1 1
8 CID000587236 O118 Stitch 3.065E-4 2.383E-2
1.779E-1
3.003E-1
 1 1
9 CID000007939 2-amino-4-methylpyrimidine Stitch 3.065E-4 2.383E-2
1.779E-1
3.003E-1
 1 1
10 CID000130890 taurolipid C Stitch 3.065E-4 2.383E-2
1.779E-1
3.003E-1
 1 1
11 CID000593843 4-Amino-5-chloro-2,6-dimethylpyrimidine Stitch 3.065E-4 2.383E-2
1.779E-1
3.003E-1
 1 1
12 CID000068039 kyanmethin Stitch 3.065E-4 2.383E-2
1.779E-1
3.003E-1
 1 1
13 CID000130456 JM118 Stitch 6.129E-4 2.383E-2
1.779E-1
6.006E-1
 1 2
14 CID006365493 7-tricosene Stitch 6.129E-4 2.383E-2
1.779E-1
6.006E-1
 1 2
15 CID000013021 2-amino-4,6-dimethylpyrimidine Stitch 6.129E-4 2.383E-2
1.779E-1
6.006E-1
 1 2
16 CID000151248 2-CBSU Stitch 6.129E-4 2.383E-2
1.779E-1
6.006E-1
 1 2
17 ctd:C560580 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide CTD 9.192E-4 2.383E-2
1.779E-1
9.008E-1
 1 3
18 CID000016658 N-aminopiperidine Stitch 9.192E-4 2.383E-2
1.779E-1
9.008E-1
 1 3
19 CID000001645 3-aminobenzamide Stitch 9.517E-4 2.383E-2
1.779E-1
9.326E-1
 2 156
20 CID000003616 HMBA Stitch 9.638E-4 2.383E-2
1.779E-1
9.445E-1
 2 157
21 CID005276916 pMTT Stitch 1.225E-3 2.383E-2
1.779E-1
1.000E0
 1 4
22 CID000005192 sebacate Stitch 1.278E-3 2.383E-2
1.779E-1
1.000E0
 2 181
23 1323 DN Cefadroxil [50370-12-2]; Down 200; 11uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.348E-3 2.383E-2
1.779E-1
1.000E0
 2 186
24 1742 UP Scoulerine [6451-73-6]; Up 200; 12.2uM; HL60; HG-U133A Broad Institute CMAP Up 1.392E-3 2.383E-2
1.779E-1
1.000E0
 2 189
25 CID000439200 AC1L96VB Stitch 1.421E-3 2.383E-2
1.779E-1
1.000E0
 2 191
26 7503 DN trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.421E-3 2.383E-2
1.779E-1
1.000E0
 2 191
27 6573 UP PNU-0293363 [326823-19-2]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.436E-3 2.383E-2
1.779E-1
1.000E0
 2 192
28 3098 DN Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.383E-2
1.779E-1
1.000E0
 2 193
29 1061 UP nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 1.465E-3 2.383E-2
1.779E-1
1.000E0
 2 194
30 1409 DN Etofylline [519-37-9]; Down 200; 17.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.465E-3 2.383E-2
1.779E-1
1.000E0
 2 194
31 2655 DN Domperidone maleate; Down 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.465E-3 2.383E-2
1.779E-1
1.000E0
 2 194
32 221 UP 17-AAG; Up 200; 0.1uM; MCF7; HG-U133A Broad Institute CMAP Up 1.480E-3 2.383E-2
1.779E-1
1.000E0
 2 195
33 2359 DN Tolbutamide [64-77-7]; Down 200; 14.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.383E-2
1.779E-1
1.000E0
 2 195
34 338 UP azathioprine, USP; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Up 1.480E-3 2.383E-2
1.779E-1
1.000E0
 2 195
35 1967 UP Sulpiride [15676-16-1]; Up 200; 11.8uM; HL60; HG-U133A Broad Institute CMAP Up 1.495E-3 2.383E-2
1.779E-1
1.000E0
 2 196
36 4993 DN Estrone [53-16-7]; Down 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.383E-2
1.779E-1
1.000E0
 2 196
37 4840 DN Buflomedil hydrochloride [35543-24-9]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.383E-2
1.779E-1
1.000E0
 2 196
38 4815 DN Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.383E-2
1.779E-1
1.000E0
 2 196
39 1718 UP Phenindione [83-12-5]; Up 200; 18uM; HL60; HG-U133A Broad Institute CMAP Up 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
40 202 UP raloxifene hydrochloride; Up 200; 0.1uM; MCF7; HG-U133A Broad Institute CMAP Up 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
41 4824 UP Letrozole [112809-51-5]; Up 200; 14uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
42 6558 DN 5194442; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
43 1944 DN Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HG-U133A Broad Institute CMAP Down 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
44 1587 DN Practolol [6673-35-4]; Down 200; 15uM; HL60; HG-U133A Broad Institute CMAP Down 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
45 161 DN (+/-)-verapamil hydrochloride; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 1.511E-3 2.383E-2
1.779E-1
1.000E0
 2 197
46 2018 UP Oleandomycin phosphate [7060-74-4]; Up 200; 5uM; HL60; HG-U133A Broad Institute CMAP Up 1.526E-3 2.383E-2
1.779E-1
1.000E0
 2 198
47 4809 DN Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.526E-3 2.383E-2
1.779E-1
1.000E0
 2 198
48 5316 UP Glycocholic acid [475-31-0]; Up 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.526E-3 2.383E-2
1.779E-1
1.000E0
 2 198
49 1625 DN GBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; HL60; HG-U133A Broad Institute CMAP Down 1.526E-3 2.383E-2
1.779E-1
1.000E0
 2 198
50 7095 UP SC 19220; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.526E-3 2.383E-2
1.779E-1
1.000E0
 2 198
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 350 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0030312 Pancytopenia DisGeNET Curated 5.962E-8 2.087E-5 1.343E-4 2.087E-5 4 106
2 C0265965 Dyskeratosis Congenita DisGeNET Curated 4.481E-7 7.841E-5 5.047E-4 1.568E-4 3 39
3 C0023492 Leukemia, T-Cell DisGeNET Curated 7.523E-6 7.683E-4 4.945E-3 2.633E-3 4 355
4 C1846142 HOYERAAL-HREIDARSSON SYNDROME DisGeNET Curated 8.781E-6 7.683E-4 4.945E-3 3.073E-3 2 11
5 C1835047 MELANOMA, CUTANEOUS MALIGNANT, 1 DisGeNET Curated 1.675E-5 1.172E-3 7.547E-3 5.862E-3 2 15
6 C1512419 Hereditary Melanoma DisGeNET Curated 1.058E-4 5.400E-3 3.475E-2 3.702E-2 2 37
7 C1857042 Sparse scalp hair DisGeNET Curated 1.366E-4 5.400E-3 3.475E-2 4.781E-2 2 42
8 C0398791 Nijmegen Breakage Syndrome DisGeNET Curated 2.705E-4 5.400E-3 3.475E-2
9.467E-2
 2 59
9 C0009207 Cockayne Syndrome DisGeNET Curated 3.919E-4 5.400E-3 3.475E-2
1.372E-1
 2 71
10 C4280623 Rotting teeth DisGeNET Curated 4.257E-4 5.400E-3 3.475E-2
1.490E-1
 2 74
11 cv:CN189144 Melanoma, cutaneous malignant, susceptibility to, 10 Clinical Variations 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
12 C4225278 GLIOMA SUSCEPTIBILITY 9 DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
13 cv:CN033164 Seckel syndrome 1 Clinical Variations 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
14 C1859478 Hypoplasia of proximal fibula DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
15 OMIN:268130 REVESZ SYNDROME OMIM 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
16 C1856911 Ivory epiphyses DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
17 C3151445 DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT, 3 DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
18 C1327916 REVESZ SYNDROME (disorder) DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
19 cv:C1327916 Revesz syndrome Clinical Variations 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
20 C1859477 Hypoplasia of proximal radius DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
21 C4024828 Fine, reticulate skin pigmentation DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
22 cv:C3151445 Dyskeratosis congenita, autosomal dominant, 3 Clinical Variations 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
23 cv:C3281203 Cutaneous telangiectasia and cancer syndrome, familial Clinical Variations 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
24 C3281203 CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
25 C4014476 MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 10 DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
26 C4225284 DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 6 DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
27 C1859470 Large basal ganglia DisGeNET Curated 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
28 OMIN:210600 SECKEL SYNDROME 1; SCKL1 OMIM 4.320E-4 5.400E-3 3.475E-2
1.512E-1
 1 1
29 C0259817 Xerosis DisGeNET Curated 4.850E-4 5.854E-3 3.768E-2
1.698E-1
 2 79
30 C0151908 Dry skin DisGeNET Curated 5.880E-4 6.860E-3 4.415E-2
2.058E-1
 2 87
31 C0152458 Leukocoria DisGeNET Curated 8.638E-4 8.892E-3
5.723E-2
3.023E-1
 1 2
32 C0003081 Anisometropia DisGeNET Curated 8.638E-4 8.892E-3
5.723E-2
3.023E-1
 1 2
33 C2677299 CEREBRORETINAL MICROANGIOPATHY WITH CALCIFICATIONS AND CYSTS (disorder) DisGeNET Curated 8.638E-4 8.892E-3
5.723E-2
3.023E-1
 1 2
34 C1855102 Methylmalonic aciduria cblB type DisGeNET Curated 8.638E-4 8.892E-3
5.723E-2
3.023E-1
 1 2
35 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 9.153E-4 9.153E-3
5.891E-2
3.203E-1
 3 497
36 C1859455 Small anterior fontanelle DisGeNET Curated 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
37 cv:C1851970 Dyskeratosis congenita autosomal dominant Clinical Variations 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
38 C1859481 Abnormal finger flexion creases DisGeNET Curated 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
39 C1563697 Chromosome Instability Syndromes DisGeNET BeFree 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
40 C1851970 DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT DisGeNET Curated 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
41 OMIN:127550 DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT OMIM 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
42 C0796003 Juberg-Marsidi syndrome DisGeNET Curated 1.295E-3 1.080E-2
6.948E-2
4.534E-1
 1 3
43 C0002874 Aplastic Anemia DisGeNET Curated 1.513E-3 1.231E-2
7.925E-2
5.294E-1
 2 140
44 C0011334 Dental caries DisGeNET Curated 1.644E-3 1.286E-2
8.277E-2
5.752E-1
 2 146
45 C1849392 Ridged fingernails DisGeNET Curated 1.727E-3 1.286E-2
8.277E-2
6.044E-1
 1 4
46 C0544848 Dystrophy, granular DisGeNET BeFree 1.727E-3 1.286E-2
8.277E-2
6.044E-1
 1 4
47 C0878660 Proportionate short stature DisGeNET Curated 1.727E-3 1.286E-2
8.277E-2
6.044E-1
 1 4
48 C0026470 Monoclonal Gammopathy of Undetermined Significance DisGeNET BeFree 1.803E-3 1.315E-2
8.462E-2
6.310E-1
 2 153
49 C4023400 Generalized hypopigmentation of hair DisGeNET Curated 2.158E-3 1.520E-2
9.785E-2
7.554E-1
 1 5
50 C1386048 Intrauterine retardation DisGeNET Curated 2.403E-3 1.520E-2
9.785E-2
8.411E-1
 2 177
Show 45 more annotations