Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc6_17, positive side

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1: GO: Molecular Function [Display Chart] 17 input genes in category / 49 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005525 GTP binding 2.162E-8 5.181E-7 2.321E-6 1.059E-6 7 378
2 GO:0032561 guanyl ribonucleotide binding 3.134E-8 5.181E-7 2.321E-6 1.536E-6 7 399
3 GO:0019001 guanyl nucleotide binding 3.189E-8 5.181E-7 2.321E-6 1.562E-6 7 400
4 GO:0003924 GTPase activity 4.229E-8 5.181E-7 2.321E-6 2.072E-6 6 236
5 GO:0051020 GTPase binding 2.909E-7 2.850E-6 1.277E-5 1.425E-5 6 327
6 GO:0017022 myosin binding 3.703E-7 3.024E-6 1.354E-5 1.814E-5 4 68
7 GO:0031489 myosin V binding 6.030E-7 4.221E-6 1.891E-5 2.955E-5 3 19
8 GO:0017016 Ras GTPase binding 3.986E-6 2.442E-5 1.094E-4 1.953E-4 5 281
9 GO:0017137 Rab GTPase binding 4.838E-6 2.634E-5 1.180E-4 2.370E-4 4 129
10 GO:0031267 small GTPase binding 5.574E-6 2.732E-5 1.223E-4 2.732E-4 5 301
11 GO:0060589 nucleoside-triphosphatase regulator activity 1.066E-5 4.750E-5 2.128E-4 5.225E-4 5 344
12 GO:0019003 GDP binding 1.978E-5 8.077E-5 3.618E-4 9.692E-4 3 59
13 GO:0030695 GTPase regulator activity 1.536E-4 5.789E-4 2.593E-3 7.526E-3 4 312
14 GO:0044325 ion channel binding 1.952E-4 6.833E-4 3.061E-3 9.566E-3 3 127
15 GO:0032028 myosin head/neck binding 9.110E-4 2.976E-3 1.333E-2 4.464E-2 1 1
16 GO:0005096 GTPase activator activity 2.005E-3 6.139E-3 2.750E-2
9.822E-2
 3 283
17 GO:0051021 GDP-dissociation inhibitor binding 5.454E-3 1.572E-2
7.042E-2
2.673E-1
 1 6
18 GO:0000149 SNARE binding 6.486E-3 1.766E-2
7.909E-2
3.178E-1
 2 134
19 GO:0019869 chloride channel inhibitor activity 8.171E-3 2.107E-2
9.439E-2
4.004E-1
 1 9
20 GO:0019855 calcium channel inhibitor activity 9.075E-3 2.117E-2
9.485E-2
4.447E-1
 1 10
21 GO:0043008 ATP-dependent protein binding 9.075E-3 2.117E-2
9.485E-2
4.447E-1
 1 10
22 GO:0032036 myosin heavy chain binding 1.268E-2 2.825E-2
1.265E-1
6.215E-1
 1 14
23 GO:0017081 chloride channel regulator activity 1.538E-2 3.191E-2
1.429E-1
7.537E-1
 1 17
24 GO:0032794 GTPase activating protein binding 1.628E-2 3.191E-2
1.429E-1
7.977E-1
 1 18
25 GO:0001671 ATPase activator activity 1.628E-2 3.191E-2
1.429E-1
7.977E-1
 1 18
26 GO:0008022 protein C-terminus binding 1.733E-2 3.265E-2
1.463E-1
8.490E-1
 2 224
27 GO:0070064 proline-rich region binding 1.807E-2 3.280E-2
1.469E-1
8.855E-1
 1 20
28 GO:0030742 GTP-dependent protein binding 1.986E-2 3.476E-2
1.557E-1
9.733E-1
 1 22
29 GO:0060590 ATPase regulator activity 2.877E-2 4.861E-2
2.177E-1
1.000E0
 1 32
Show 24 more annotations

2: GO: Biological Process [Display Chart] 15 input genes in category / 400 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:2000300 regulation of synaptic vesicle exocytosis 1.049E-11 4.196E-9 2.756E-8 4.196E-9 5 26
2 GO:0016079 synaptic vesicle exocytosis 5.198E-11 7.241E-9 4.757E-8 2.079E-8 6 90
3 GO:1902803 regulation of synaptic vesicle transport 5.984E-11 7.241E-9 4.757E-8 2.394E-8 5 36
4 GO:0017158 regulation of calcium ion-dependent exocytosis 7.241E-11 7.241E-9 4.757E-8 2.897E-8 6 95
5 GO:0017157 regulation of exocytosis 1.056E-10 8.445E-9 5.549E-8 4.223E-8 7 205
6 GO:0061025 membrane fusion 2.029E-10 1.353E-8 8.887E-8 8.116E-8 7 225
7 GO:0099504 synaptic vesicle cycle 3.168E-10 1.810E-8 1.189E-7 1.267E-7 6 121
8 GO:0051650 establishment of vesicle localization 4.485E-10 1.874E-8 1.231E-7 1.794E-7 7 252
9 GO:0006887 exocytosis 4.894E-10 1.874E-8 1.231E-7 1.958E-7 8 438
10 GO:0017156 calcium ion regulated exocytosis 5.623E-10 1.874E-8 1.231E-7 2.249E-7 6 133
11 GO:0048489 synaptic vesicle transport 5.623E-10 1.874E-8 1.231E-7 2.249E-7 6 133
12 GO:0097480 establishment of synaptic vesicle localization 5.623E-10 1.874E-8 1.231E-7 2.249E-7 6 133
13 GO:0051648 vesicle localization 6.716E-10 2.067E-8 1.358E-7 2.687E-7 7 267
14 GO:0097479 synaptic vesicle localization 8.009E-10 2.288E-8 1.503E-7 3.204E-7 6 141
15 GO:1903305 regulation of regulated secretory pathway 9.097E-10 2.426E-8 1.594E-7 3.639E-7 6 144
16 GO:0046928 regulation of neurotransmitter secretion 1.195E-9 2.988E-8 1.963E-7 4.781E-7 5 64
17 GO:0023061 signal release 1.350E-9 3.175E-8 2.086E-7 5.398E-7 8 498
18 GO:0007269 neurotransmitter secretion 1.922E-9 4.047E-8 2.659E-7 7.689E-7 6 163
19 GO:0099643 signal release from synapse 1.922E-9 4.047E-8 2.659E-7 7.689E-7 6 163
20 GO:0045055 regulated exocytosis 2.124E-9 4.247E-8 2.790E-7 8.495E-7 7 315
21 GO:0099531 presynaptic process involved in chemical synaptic transmission 2.751E-9 5.240E-8 3.443E-7 1.100E-6 6 173
22 GO:0051588 regulation of neurotransmitter transport 3.289E-9 5.979E-8 3.928E-7 1.315E-6 5 78
23 GO:0016050 vesicle organization 4.679E-9 8.138E-8 5.347E-7 1.872E-6 7 353
24 GO:0045921 positive regulation of exocytosis 8.042E-9 1.340E-7 8.806E-7 3.217E-6 5 93
25 GO:0006836 neurotransmitter transport 9.316E-9 1.491E-7 9.793E-7 3.727E-6 6 212
26 GO:0001505 regulation of neurotransmitter levels 9.855E-9 1.516E-7 9.961E-7 3.942E-6 6 214
27 GO:0051656 establishment of organelle localization 2.075E-8 3.074E-7 2.020E-6 8.301E-6 7 438
28 GO:0006906 vesicle fusion 9.533E-8 1.362E-6 8.948E-6 3.813E-5 5 152
29 GO:0090174 organelle membrane fusion 1.018E-7 1.404E-6 9.222E-6 4.071E-5 5 154
30 GO:0048284 organelle fusion 3.928E-7 5.238E-6 3.441E-5 1.571E-4 5 202
31 GO:0000045 autophagosome assembly 4.371E-7 5.640E-6 3.705E-5 1.748E-4 4 81
32 GO:1905037 autophagosome organization 5.062E-7 6.327E-6 4.157E-5 2.025E-4 4 84
33 GO:0007033 vacuole organization 5.475E-7 6.637E-6 4.360E-5 2.190E-4 5 216
34 GO:2000463 positive regulation of excitatory postsynaptic potential 1.087E-6 1.279E-5 8.402E-5 4.348E-4 3 26
35 GO:0098815 modulation of excitatory postsynaptic potential 2.971E-6 3.395E-5 2.231E-4 1.188E-3 3 36
36 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 3.506E-6 3.896E-5 2.560E-4 1.403E-3 3 38
37 GO:0050806 positive regulation of synaptic transmission 5.572E-6 6.024E-5 3.958E-4 2.229E-3 4 153
38 GO:0050804 modulation of chemical synaptic transmission 6.454E-6 6.794E-5 4.463E-4 2.582E-3 5 357
39 GO:0061669 spontaneous neurotransmitter secretion 9.066E-6 9.066E-5 5.956E-4 3.626E-3 2 6
40 GO:0098814 spontaneous synaptic transmission 9.066E-6 9.066E-5 5.956E-4 3.626E-3 2 6
41 GO:0014047 glutamate secretion 9.667E-6 9.431E-5 6.196E-4 3.867E-3 3 53
42 GO:1903307 positive regulation of regulated secretory pathway 1.142E-5 1.088E-4 7.147E-4 4.569E-3 3 56
43 GO:1903532 positive regulation of secretion by cell 1.371E-5 1.276E-4 8.380E-4 5.485E-3 5 417
44 GO:0048168 regulation of neuronal synaptic plasticity 1.554E-5 1.413E-4 9.281E-4 6.215E-3 3 62
45 GO:0097151 positive regulation of inhibitory postsynaptic potential 1.691E-5 1.503E-4 9.874E-4 6.763E-3 2 8
46 GO:0060079 excitatory postsynaptic potential 1.963E-5 1.685E-4 1.107E-3 7.854E-3 3 67
47 GO:0051047 positive regulation of secretion 1.980E-5 1.685E-4 1.107E-3 7.922E-3 5 450
48 GO:0010807 regulation of synaptic vesicle priming 2.173E-5 1.774E-4 1.165E-3 8.691E-3 2 9
49 GO:0098828 modulation of inhibitory postsynaptic potential 2.173E-5 1.774E-4 1.165E-3 8.691E-3 2 9
50 GO:0001845 phagolysosome assembly 3.317E-5 2.653E-4 1.743E-3 1.327E-2 2 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 17 input genes in category / 99 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098793 presynapse 3.622E-12 3.586E-10 1.856E-9 3.586E-10 9 341
2 GO:0045335 phagocytic vesicle 1.107E-8 5.482E-7 2.838E-6 1.096E-6 5 88
3 GO:0030139 endocytic vesicle 7.427E-8 2.451E-6 1.269E-5 7.353E-6 6 265
4 GO:0008021 synaptic vesicle 1.968E-7 4.053E-6 2.099E-5 1.948E-5 5 156
5 GO:0030670 phagocytic vesicle membrane 2.047E-7 4.053E-6 2.099E-5 2.027E-5 4 60
6 GO:0070382 exocytic vesicle 3.199E-7 5.279E-6 2.733E-5 3.167E-5 5 172
7 GO:0030133 transport vesicle 5.651E-7 7.993E-6 4.138E-5 5.595E-5 6 374
8 GO:0043195 terminal bouton 2.534E-6 3.136E-5 1.624E-4 2.509E-4 4 112
9 GO:0048786 presynaptic active zone 4.493E-6 4.943E-5 2.559E-4 4.448E-4 3 37
10 GO:0055037 recycling endosome 6.160E-6 6.098E-5 3.157E-4 6.098E-4 4 140
11 GO:0030666 endocytic vesicle membrane 9.456E-6 8.510E-5 4.406E-4 9.361E-4 4 156
12 GO:0043679 axon terminus 1.892E-5 1.519E-4 7.865E-4 1.873E-3 4 186
13 GO:0030141 secretory granule 1.995E-5 1.519E-4 7.865E-4 1.975E-3 5 400
14 GO:0044306 neuron projection terminus 2.466E-5 1.744E-4 9.030E-4 2.442E-3 4 199
15 GO:0097208 alveolar lamellar body 2.685E-5 1.772E-4 9.176E-4 2.659E-3 2 9
16 GO:0042734 presynaptic membrane 3.979E-5 2.462E-4 1.275E-3 3.939E-3 3 76
17 GO:0042470 melanosome 1.044E-4 5.743E-4 2.973E-3 1.034E-2 3 105
18 GO:0048770 pigment granule 1.044E-4 5.743E-4 2.973E-3 1.034E-2 3 105
19 GO:0033267 axon part 1.364E-4 6.842E-4 3.543E-3 1.351E-2 4 309
20 GO:0042599 lamellar body 1.409E-4 6.842E-4 3.543E-3 1.395E-2 2 20
21 GO:0005769 early endosome 1.451E-4 6.842E-4 3.543E-3 1.437E-2 4 314
22 GO:0030658 transport vesicle membrane 3.489E-4 1.561E-3 8.081E-3 3.454E-2 3 158
23 GO:0010008 endosome membrane 3.626E-4 1.561E-3 8.081E-3 3.590E-2 4 399
24 GO:0044440 endosomal part 4.985E-4 2.056E-3 1.065E-2 4.935E-2 4 434
25 GO:0032419 extrinsic component of lysosome membrane 8.919E-4 3.396E-3 1.758E-2
8.830E-2
 1 1
26 GO:0031260 pseudopodium membrane 8.919E-4 3.396E-3 1.758E-2
8.830E-2
 1 1
27 GO:0099501 exocytic vesicle membrane 1.328E-3 4.697E-3 2.432E-2
1.315E-1
 2 61
28 GO:0030672 synaptic vesicle membrane 1.328E-3 4.697E-3 2.432E-2
1.315E-1
 2 61
29 GO:0098559 cytoplasmic side of early endosome membrane 1.783E-3 6.087E-3 3.151E-2
1.765E-1
 1 2
30 GO:0097060 synaptic membrane 2.187E-3 7.216E-3 3.736E-2
2.165E-1
 3 298
31 GO:0005776 autophagosome 2.384E-3 7.614E-3 3.942E-2
2.360E-1
 2 82
32 GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane 2.673E-3 7.784E-3 4.030E-2
2.647E-1
 1 3
33 GO:0010009 cytoplasmic side of endosome membrane 2.673E-3 7.784E-3 4.030E-2
2.647E-1
 1 3
34 GO:0060200 clathrin-sculpted acetylcholine transport vesicle 2.673E-3 7.784E-3 4.030E-2
2.647E-1
 1 3
35 GO:0060203 clathrin-sculpted glutamate transport vesicle membrane 3.563E-3 9.283E-3 4.806E-2
3.527E-1
 1 4
36 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex 3.563E-3 9.283E-3 4.806E-2
3.527E-1
 1 4
37 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex 3.563E-3 9.283E-3 4.806E-2
3.527E-1
 1 4
38 GO:0060199 clathrin-sculpted glutamate transport vesicle 3.563E-3 9.283E-3 4.806E-2
3.527E-1
 1 4
39 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex 4.452E-3 1.072E-2
5.550E-2
4.407E-1
 1 5
40 GO:0070081 clathrin-sculpted monoamine transport vesicle 4.452E-3 1.072E-2
5.550E-2
4.407E-1
 1 5
41 GO:0070083 clathrin-sculpted monoamine transport vesicle membrane 4.452E-3 1.072E-2
5.550E-2
4.407E-1
 1 5
42 GO:0031901 early endosome membrane 4.547E-3 1.072E-2
5.550E-2
4.502E-1
 2 114
43 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 7.114E-3 1.565E-2
8.103E-2
7.043E-1
 1 8
44 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle 7.114E-3 1.565E-2
8.103E-2
7.043E-1
 1 8
45 GO:0000306 extrinsic component of vacuolar membrane 7.114E-3 1.565E-2
8.103E-2
7.043E-1
 1 8
46 GO:0033162 melanosome membrane 8.000E-3 1.685E-2
8.724E-2
7.920E-1
 1 9
47 GO:0045009 chitosome 8.000E-3 1.685E-2
8.724E-2
7.920E-1
 1 9
48 GO:0030136 clathrin-coated vesicle 8.979E-3 1.852E-2
9.588E-2
8.889E-1
 2 162
49 GO:0060198 clathrin-sculpted vesicle 1.065E-2 2.152E-2
1.114E-1
1.000E0
 1 12
50 GO:0042589 zymogen granule membrane 1.242E-2 2.459E-2
1.273E-1
1.000E0
 1 14
Show 45 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 739 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 13 input genes in category / 293 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004792 abnormal synaptic vesicle number 3.493E-5 7.436E-3 4.654E-2 1.023E-2 3 53
2 MP:0004769 abnormal synaptic vesicle morphology 5.076E-5 7.436E-3 4.654E-2 1.487E-2 3 60

6: Domain [Display Chart] 17 input genes in category / 77 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS51419 RAB PROSITE 1.913E-13 1.473E-11 7.260E-11 1.473E-11 7 73
2 PF00071 Ras Pfam 1.664E-11 6.406E-10 3.157E-9 1.281E-9 7 136
3 IPR001806 Small GTPase InterPro 5.256E-11 1.349E-9 6.648E-9 4.047E-9 7 160
4 IPR005225 Small GTP-bd dom InterPro 7.110E-11 1.369E-9 6.744E-9 5.475E-9 7 167
5 PF00168 C2 Pfam 5.063E-6 7.670E-5 3.780E-4 3.899E-4 4 131
6 SM00239 C2 SMART 6.049E-6 7.670E-5 3.780E-4 4.658E-4 4 137
7 PS50004 C2 PROSITE 6.973E-6 7.670E-5 3.780E-4 5.369E-4 4 142
8 2.60.40.150 - Gene3D 8.215E-6 7.907E-5 3.896E-4 6.326E-4 4 148
9 IPR000008 C2 dom InterPro 1.233E-5 1.055E-4 5.196E-4 9.491E-4 4 164
10 PF02318 FYVE 2 Pfam 4.242E-5 3.265E-4 1.609E-3 3.266E-3 2 11
11 PS50916 RABBD PROSITE 5.088E-5 3.265E-4 1.609E-3 3.917E-3 2 12
12 IPR010911 Rab BD InterPro 5.088E-5 3.265E-4 1.609E-3 3.917E-3 2 12
13 IPR017455 Znf FYVE-rel InterPro 4.274E-4 2.531E-3 1.247E-2 3.291E-2 2 34
14 IPR000306 Znf FYVE InterPro 5.344E-4 2.939E-3 1.448E-2 4.115E-2 2 38
15 PS50178 ZF FYVE PROSITE 5.923E-4 3.041E-3 1.498E-2 4.561E-2 2 40
16 IPR030631 RIM2 InterPro 9.074E-4 3.327E-3 1.639E-2
6.987E-2
 1 1
17 IPR033564 TBC1D4 InterPro 9.074E-4 3.327E-3 1.639E-2
6.987E-2
 1 1
18 IPR030630 RIM1 InterPro 9.074E-4 3.327E-3 1.639E-2
6.987E-2
 1 1
19 IPR030702 Rab14 InterPro 9.074E-4 3.327E-3 1.639E-2
6.987E-2
 1 1
20 IPR029880 Rabaptin-5 InterPro 9.074E-4 3.327E-3 1.639E-2
6.987E-2
 1 1
21 IPR030535 Doc2a InterPro 9.074E-4 3.327E-3 1.639E-2
6.987E-2
 1 1
22 IPR021785 DUF3350 InterPro 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
23 IPR028669 STX1A/1B InterPro 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
24 IPR019323 ELKS/CAST InterPro 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
25 PF11830 DUF3350 Pfam 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
26 IPR014638 Doc2 InterPro 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
27 PF03528 Rabaptin Pfam 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
28 PF10174 Cast Pfam 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
29 IPR003914 Rabaptin InterPro 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
30 IPR018514 Rabaptin coiled-coil InterPro 1.814E-3 4.656E-3 2.294E-2
1.397E-1
 1 2
31 IPR004895 Prenylated rab accept PRA1 InterPro 2.720E-3 6.545E-3 3.225E-2
2.094E-1
 1 3
32 PF03208 PRA1 Pfam 2.720E-3 6.545E-3 3.225E-2
2.094E-1
 1 3
33 PF09311 Rab5-bind Pfam 5.433E-3 1.131E-2
5.571E-2
4.183E-1
 1 6
34 PF09457 RBD-FIP Pfam 5.433E-3 1.131E-2
5.571E-2
4.183E-1
 1 6
35 PS51511 FIP RBD PROSITE 5.433E-3 1.131E-2
5.571E-2
4.183E-1
 1 6
36 IPR019018 Rab-bd FIP-RBD InterPro 5.433E-3 1.131E-2
5.571E-2
4.183E-1
 1 6
37 IPR015390 Rabaptin Rab5-bd dom InterPro 5.433E-3 1.131E-2
5.571E-2
4.183E-1
 1 6
38 PF00595 PDZ Pfam 7.103E-3 1.405E-2
6.923E-2
5.469E-1
 2 141
39 SM00167 VPS9 SMART 7.237E-3 1.405E-2
6.923E-2
5.573E-1
 1 8
40 IPR011011 Znf FYVE PHD InterPro 7.698E-3 1.405E-2
6.923E-2
5.927E-1
 2 147
41 SM00228 PDZ SMART 7.799E-3 1.405E-2
6.923E-2
6.005E-1
 2 148
42 2.30.42.10 - Gene3D 8.004E-3 1.405E-2
6.923E-2
6.163E-1
 2 150
43 PS50106 PDZ PROSITE 8.107E-3 1.405E-2
6.923E-2
6.242E-1
 2 151
44 SM00503 SynN SMART 8.139E-3 1.405E-2
6.923E-2
6.267E-1
 1 9
45 IPR001478 PDZ InterPro 8.210E-3 1.405E-2
6.923E-2
6.322E-1
 2 152
46 PF02204 VPS9 Pfam 9.039E-3 1.450E-2
7.145E-2
6.960E-1
 1 10
47 PS51205 VPS9 PROSITE 9.039E-3 1.450E-2
7.145E-2
6.960E-1
 1 10
48 IPR003123 VPS9 InterPro 9.039E-3 1.450E-2
7.145E-2
6.960E-1
 1 10
49 PF00804 Syntaxin Pfam 9.939E-3 1.562E-2
7.696E-2
7.653E-1
 1 11
50 IPR006011 Syntaxin N InterPro 1.084E-2 1.669E-2
8.224E-2
8.345E-1
 1 12
Show 45 more annotations

7: Pathway [Display Chart] 14 input genes in category / 92 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1470928 RAB geranylgeranylation BioSystems: REACTOME 2.827E-13 2.601E-11 1.328E-10 2.601E-11 7 66
2 1457806 RAB GEFs exchange GTP for GDP on RABs BioSystems: REACTOME 3.697E-10 1.511E-8 7.712E-8 3.401E-8 6 91
3 M8179 Rab GTPases Mark Targets In The Endocytotic Machinery MSigDB C2 BIOCARTA (v6.0) 4.927E-10 1.511E-8 7.712E-8 4.532E-8 4 12
4 P05734 Synaptic vesicle trafficking PantherDB 8.751E-9 2.013E-7 1.027E-6 8.051E-7 4 23
5 PW:0000159 Rab family mediated signaling Pathway Ontology 9.471E-8 1.743E-6 8.895E-6 8.713E-6 3 9
6 1268773 Acetylcholine Neurotransmitter Release Cycle BioSystems: REACTOME 7.627E-7 9.985E-6 5.097E-5 7.016E-5 3 17
7 1268769 Norepinephrine Neurotransmitter Release Cycle BioSystems: REACTOME 9.146E-7 9.985E-6 5.097E-5 8.414E-5 3 18
8 1268770 Serotonin Neurotransmitter Release Cycle BioSystems: REACTOME 9.146E-7 9.985E-6 5.097E-5 8.414E-5 3 18
9 1268774 GABA synthesis, release, reuptake and degradation BioSystems: REACTOME 1.085E-6 9.985E-6 5.097E-5 9.985E-5 3 19
10 PW:0000639 insulin responsive facilitative sugar transporter mediated glucose transport pathway Pathway Ontology 1.085E-6 9.985E-6 5.097E-5 9.985E-5 3 19
11 1268772 Dopamine Neurotransmitter Release Cycle BioSystems: REACTOME 1.978E-6 1.655E-5 8.446E-5 1.820E-4 3 23
12 1268771 Glutamate Neurotransmitter Release Cycle BioSystems: REACTOME 2.259E-6 1.732E-5 8.842E-5 2.079E-4 3 24
13 1470925 TBC/RABGAPs BioSystems: REACTOME 1.783E-5 1.262E-4 6.440E-4 1.640E-3 3 47
14 1268768 Neurotransmitter Release Cycle BioSystems: REACTOME 2.284E-5 1.501E-4 7.660E-4 2.101E-3 3 51
15 138028 Effects of Botulinum toxin BioSystems: Pathway Interaction Database 4.208E-5 2.484E-4 1.268E-3 3.872E-3 2 9
16 373900 Synaptic vesicle cycle BioSystems: KEGG 4.320E-5 2.484E-4 1.268E-3 3.974E-3 3 63
17 777534 Insulin secretion BioSystems: KEGG 1.059E-4 5.641E-4 2.880E-3 9.742E-3 3 85
18 102279 Endocytosis BioSystems: KEGG 1.577E-4 5.641E-4 2.880E-3 1.451E-2 4 260
19 SMP00246 Pirenzepine Pathway SMPDB 1.582E-4 5.641E-4 2.880E-3 1.455E-2 2 17
20 SMP00232 Cimetidine Pathway SMPDB 1.582E-4 5.641E-4 2.880E-3 1.455E-2 2 17
21 PW:0000674 insulin secretion pathway Pathway Ontology 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
22 SMP00230 Ranitidine Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
23 SMP00225 Esomeprazole Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
24 SMP00231 Famotidine Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
25 SMP00233 Nizatidine Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
26 SMP00229 Rabeprazole Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
27 SMP00227 Lansoprazole Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
28 SMP00228 Pantoprazole Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
29 SMP00226 Omeprazole Pathway SMPDB 1.778E-4 5.641E-4 2.880E-3 1.636E-2 2 18
30 1270077 Synthesis of PIPs at the plasma membrane BioSystems: REACTOME 1.395E-3 4.277E-3 2.183E-2
1.283E-1
 2 50
31 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 1.671E-3 4.960E-3 2.532E-2
1.538E-1
 3 218
32 1269896 Translocation of GLUT4 to the plasma membrane BioSystems: REACTOME 2.137E-3 6.143E-3 3.135E-2
1.966E-1
 2 62
33 1269150 Toxicity of botulinum toxin type C (BoNT/C) BioSystems: REACTOME 3.370E-3 9.317E-3 4.756E-2
3.100E-1
 1 3
34 1270073 PI Metabolism BioSystems: REACTOME 3.443E-3 9.317E-3 4.756E-2
3.168E-1
 2 79
35 167324 Amoebiasis BioSystems: KEGG 5.041E-3 1.325E-2
6.764E-2
4.638E-1
 2 96
36 1268763 Neuronal System BioSystems: REACTOME 6.418E-3 1.640E-2
8.371E-2
5.904E-1
 3 351
37 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 1.003E-2 2.494E-2
1.273E-1
9.229E-1
 2 137
38 1269145 Neurotoxicity of clostridium toxins BioSystems: REACTOME 1.119E-2 2.710E-2
1.383E-1
1.000E0
 1 10
39 153910 Phagosome BioSystems: KEGG 1.255E-2 2.960E-2
1.511E-1
1.000E0
 2 154
40 1269812 Golgi Cisternae Pericentriolar Stack Reorganization BioSystems: REACTOME 1.564E-2 3.583E-2
1.829E-1
1.000E0
 1 14
41 1457780 Neutrophil degranulation BioSystems: REACTOME 1.613E-2 3.583E-2
1.829E-1
1.000E0
 3 492
42 213780 Tuberculosis BioSystems: KEGG 1.670E-2 3.583E-2
1.829E-1
1.000E0
 2 179
43 1270349 LGI-ADAM interactions BioSystems: REACTOME 1.674E-2 3.583E-2
1.829E-1
1.000E0
 1 15
44 1270053 Phospholipid metabolism BioSystems: REACTOME 2.215E-2 4.631E-2
2.364E-1
1.000E0
 2 208
Show 39 more annotations

8: Pubmed [Display Chart] 17 input genes in category / 1530 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11856727 Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Pubmed 1.449E-16 1.422E-13 1.125E-12 2.218E-13 7 54
2 12578829 Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Pubmed 2.789E-16 1.422E-13 1.125E-12 4.267E-13 7 59
3 11773082 The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Pubmed 2.789E-16 1.422E-13 1.125E-12 4.267E-13 7 59
4 17124501 Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. Pubmed 3.848E-16 1.472E-13 1.164E-12 5.888E-13 6 24
5 16923123 Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Pubmed 8.800E-16 2.693E-13 2.130E-12 1.346E-12 7 69
6 26032412 Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP). Pubmed 7.324E-11 1.868E-8 1.477E-7 1.121E-7 3 3
7 26399387 A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton. Pubmed 2.929E-10 4.979E-8 3.939E-7 4.481E-7 3 4
8 27537483 Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. Pubmed 2.929E-10 4.979E-8 3.939E-7 4.481E-7 3 4
9 9341137 Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. Pubmed 2.929E-10 4.979E-8 3.939E-7 4.481E-7 3 4
10 7991565 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Pubmed 7.320E-10 1.120E-7 8.859E-7 1.120E-6 3 5
11 15217342 The synaptic vesicle cycle. Pubmed 8.386E-10 1.166E-7 9.227E-7 1.283E-6 4 31
12 29398114 Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Pubmed 1.464E-9 1.400E-7 1.107E-6 2.239E-6 3 6
13 11056535 cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Pubmed 1.464E-9 1.400E-7 1.107E-6 2.239E-6 3 6
14 8294464 REP-2, a Rab escort protein encoded by the choroideremia-like gene. Pubmed 1.464E-9 1.400E-7 1.107E-6 2.239E-6 3 6
15 14734538 Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. Pubmed 1.464E-9 1.400E-7 1.107E-6 2.239E-6 3 6
16 10707984 Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Pubmed 1.464E-9 1.400E-7 1.107E-6 2.239E-6 3 6
17 2501306 The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. Pubmed 2.561E-9 2.062E-7 1.631E-6 3.918E-6 3 7
18 2493636 Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT related protein. Pubmed 2.561E-9 2.062E-7 1.631E-6 3.918E-6 3 7
19 16722236 The role of SNARE proteins in trafficking and function of neurotransmitter transporters. Pubmed 2.561E-9 2.062E-7 1.631E-6 3.918E-6 3 7
20 11718716 Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. Pubmed 4.096E-9 2.984E-7 2.361E-6 6.267E-6 3 8
21 16902405 Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. Pubmed 4.096E-9 2.984E-7 2.361E-6 6.267E-6 3 8
22 10329441 Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). Pubmed 8.772E-9 6.100E-7 4.826E-6 1.342E-5 3 10
23 18022941 Protein partners in the life history of activated fibroblast growth factor receptors. Pubmed 1.204E-8 8.008E-7 6.335E-6 1.842E-5 4 59
24 24006491 Identification and characterization of multiple novel Rab-myosin Va interactions. Pubmed 2.658E-8 1.694E-6 1.340E-5 4.067E-5 3 14
25 21255211 Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Pubmed 5.952E-8 3.642E-6 2.881E-5 9.106E-5 3 18
26 19723784 Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. Pubmed 1.474E-7 6.484E-6 5.129E-5 2.255E-4 3 24
27 15935055 Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. Pubmed 1.674E-7 6.484E-6 5.129E-5 2.562E-4 3 25
28 20847427 Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
29 25155955 Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
30 28701482 Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
31 8521472 Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
32 22753485 RIM genes differentially contribute to organizing presynaptic release sites. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
33 23536683 Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
34 20472552 Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
35 29606581 RIM C Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
36 28634871 Rabies virus co-localizes with early (Rab5) and late (Rab7) endosomal proteins in neuronal and SH-SY5Y cells. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
37 26400943 RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
38 15378032 Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
39 22956829 The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
40 15967982 Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
41 11884041 SNARE complex assembly is required for human sperm acrosome reaction. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
42 23592992 Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
43 25566515 The complexity of Rab5 to Rab7 transition guarantees specificity of pathogen subversion mechanisms. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
44 12034881 The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production. Pubmed 1.865E-7 6.484E-6 5.129E-5 2.853E-4 2 2
45 21262468 RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Pubmed 5.593E-7 1.240E-5 9.810E-5 8.557E-4 2 3
46 15066271 The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Pubmed 5.593E-7 1.240E-5 9.810E-5 8.557E-4 2 3
47 20169068 Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis. Pubmed 5.593E-7 1.240E-5 9.810E-5 8.557E-4 2 3
48 23815289 Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy. Pubmed 5.593E-7 1.240E-5 9.810E-5 8.557E-4 2 3
49 18385674 Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Pubmed 5.593E-7 1.240E-5 9.810E-5 8.557E-4 2 3
50 28922401 Rab11 family expression in the human placenta: Localization at the maternal-fetal interface. Pubmed 5.593E-7 1.240E-5 9.810E-5 8.557E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 17 input genes in category / 776 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RABAC1 RABAC1 interactions 4.759E-11 3.288E-8 2.378E-7 3.693E-8 6 73
2 int:CHM CHM interactions 8.475E-11 3.288E-8 2.378E-7 6.576E-8 5 32
3 int:GDI1 GDI1 interactions 2.251E-10 5.822E-8 4.211E-7 1.747E-7 6 94
4 int:RAB4A RAB4A interactions 6.401E-10 1.242E-7 8.980E-7 4.967E-7 5 47
5 int:RAB11B RAB11B interactions 1.340E-8 1.761E-6 1.274E-5 1.040E-5 5 85
6 int:RIMS1 RIMS1 interactions 1.362E-8 1.761E-6 1.274E-5 1.057E-5 4 29
7 int:RAB11A RAB11A interactions 3.539E-8 3.923E-6 2.837E-5 2.746E-5 5 103
8 int:RAB2B RAB2B interactions 4.688E-8 4.547E-6 3.288E-5 3.638E-5 4 39
9 int:RAB5A RAB5A interactions 9.745E-8 7.851E-6 5.678E-5 7.562E-5 5 126
10 int:RAB3A RAB3A interactions 1.012E-7 7.851E-6 5.678E-5 7.851E-5 4 47
11 int:BSN BSN interactions 1.208E-7 8.521E-6 6.162E-5 9.373E-5 3 11
12 int:RAB22A RAB22A interactions 2.660E-7 1.639E-5 1.185E-4 2.064E-4 3 14
13 int:GDI2 GDI2 interactions 2.745E-7 1.639E-5 1.185E-4 2.130E-4 4 60
14 int:RIMS2 RIMS2 interactions 5.949E-7 3.146E-5 2.275E-4 4.616E-4 3 18
15 int:DGUOK DGUOK interactions 6.080E-7 3.146E-5 2.275E-4 4.718E-4 4 73
16 int:RAB1A RAB1A interactions 6.777E-7 3.287E-5 2.377E-4 5.259E-4 5 186
17 int:RABGGTB RABGGTB interactions 8.364E-7 3.818E-5 2.761E-4 6.490E-4 4 79
18 int:RAB4B RAB4B interactions 1.120E-6 4.574E-5 3.308E-4 8.691E-4 3 22
19 int:UNC13B UNC13B interactions 1.120E-6 4.574E-5 3.308E-4 8.691E-4 3 22
20 int:CHML CHML interactions 1.470E-6 5.705E-5 4.126E-4 1.141E-3 3 24
21 int:RAP1A RAP1A interactions 1.908E-6 7.014E-5 5.072E-4 1.481E-3 4 97
22 int:RAB8A RAB8A interactions 1.988E-6 7.014E-5 5.072E-4 1.543E-3 4 98
23 int:RABGGTA RABGGTA interactions 2.646E-6 8.929E-5 6.457E-4 2.054E-3 3 29
24 int:RAB11FIP1 RAB11FIP1 interactions 2.939E-6 9.502E-5 6.872E-4 2.280E-3 3 30
25 int:RAB27A RAB27A interactions 3.942E-6 1.224E-4 8.849E-4 3.059E-3 3 33
26 int:RAB3B RAB3B interactions 5.150E-6 1.537E-4 1.112E-3 3.996E-3 3 36
27 int:HAX1 HAX1 interactions 9.459E-6 2.719E-4 1.966E-3 7.340E-3 4 145
28 int:RAB37 RAB37 interactions 1.299E-5 3.528E-4 2.552E-3 1.008E-2 2 6
29 int:RAB6A RAB6A interactions 1.319E-5 3.528E-4 2.552E-3 1.023E-2 3 49
30 int:RAB5C RAB5C interactions 1.538E-5 3.979E-4 2.877E-3 1.194E-2 4 164
31 int:OCRL OCRL interactions 1.770E-5 4.408E-4 3.188E-3 1.374E-2 3 54
32 int:ZFYVE28 ZFYVE28 interactions 1.818E-5 4.408E-4 3.188E-3 1.410E-2 2 7
33 int:FGFR1 FGFR1 interactions 2.123E-5 4.993E-4 3.611E-3 1.648E-2 4 178
34 int:RUFY1 RUFY1 interactions 2.313E-5 5.279E-4 3.818E-3 1.795E-2 3 59
35 int:RAB7A RAB7A interactions 2.687E-5 5.956E-4 4.308E-3 2.085E-2 4 189
36 int:RAB3C RAB3C interactions 3.112E-5 6.709E-4 4.852E-3 2.415E-2 2 9
37 int:RAB5B RAB5B interactions 3.547E-5 7.438E-4 5.379E-3 2.752E-2 3 68
38 int:RABEP1 RABEP1 interactions 4.211E-5 8.599E-4 6.218E-3 3.267E-2 3 72
39 int:SNCA SNCA interactions 4.779E-5 9.509E-4 6.877E-3 3.709E-2 4 219
40 int:DNAAF2 DNAAF2 interactions 6.445E-5 1.250E-3 9.042E-3
5.001E-2
 3 83
41 int:PCLO PCLO interactions 6.728E-5 1.273E-3 9.209E-3
5.221E-2
 2 13
42 int:RPH3AL RPH3AL interactions 9.047E-5 1.633E-3 1.181E-2
7.020E-2
 2 15
43 int:RAB33B RAB33B interactions 9.047E-5 1.633E-3 1.181E-2
7.020E-2
 2 15
44 int:RAB1B RAB1B interactions 9.341E-5 1.647E-3 1.191E-2
7.248E-2
 3 94
45 int:MTSS1 MTSS1 interactions 1.033E-4 1.782E-3 1.289E-2
8.019E-2
 2 16
46 int:RAB17 RAB17 interactions 1.470E-4 2.427E-3 1.755E-2
1.141E-1
 2 19
47 int:RAB3D RAB3D interactions 1.470E-4 2.427E-3 1.755E-2
1.141E-1
 2 19
48 int:CDC34 CDC34 interactions 1.535E-4 2.481E-3 1.795E-2
1.191E-1
 4 296
49 int:NUFIP1 NUFIP1 interactions 1.788E-4 2.832E-3 2.048E-2
1.388E-1
 3 117
50 int:RAB2A RAB2A interactions 1.927E-4 2.991E-3 2.163E-2
1.495E-1
 3 120
Show 45 more annotations

10: Cytoband [Display Chart] 17 input genes in category / 17 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9q32-q34.11 9q32-q34.11 4.905E-4 5.557E-3 1.911E-2 8.338E-3 1 1
2 6p11 6p11 9.807E-4 5.557E-3 1.911E-2 1.667E-2 1 2
3 3p24-p22 3p24-p22 9.807E-4 5.557E-3 1.911E-2 1.667E-2 1 2
4 6q12-q13 6q12-q13 2.450E-3 1.041E-2 3.582E-2 4.165E-2 1 5
5 13q22.2 13q22.2 3.917E-3 1.332E-2 4.581E-2
6.660E-2
 1 8
6 8p11.22 8p11.22 6.846E-3 1.940E-2
6.672E-2
1.164E-1
 1 14
7 3p14.3 3p14.3 1.462E-2 3.223E-2
1.109E-1
2.485E-1
 1 30
8 2p14 2p14 1.751E-2 3.223E-2
1.109E-1
2.978E-1
 1 36
9 9q33.3 9q33.3 1.800E-2 3.223E-2
1.109E-1
3.060E-1
 1 37
10 8q22.3 8q22.3 1.896E-2 3.223E-2
1.109E-1
3.223E-1
 1 39
11 3q21.3 3q21.3 2.568E-2 3.609E-2
1.241E-1
4.366E-1
 1 53
12 1q22 1q22 2.760E-2 3.609E-2
1.241E-1
4.692E-1
 1 57
13 17p13.2 17p13.2 2.760E-2 3.609E-2
1.241E-1
4.692E-1
 1 57
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 135 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 14 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 388 RAB, member RAS oncogene GTPases genenames.org 1.791E-14 1.433E-13 3.895E-13 1.433E-13 7 65
2 833 Regulating synaptic membrane exocytosis family|PDZ domain containing genenames.org 3.296E-6 1.318E-5 3.583E-5 2.637E-5 2 4
3 1144 YIP family genenames.org 3.842E-3 1.023E-2 2.780E-2 3.074E-2 1 5
4 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 5.908E-3 1.023E-2 2.780E-2 4.726E-2 2 152
5 822 Synaptotagmin like tandem C2 proteins genenames.org 7.670E-3 1.023E-2 2.780E-2
6.136E-2
 1 10
6 928 VPS9 domain containing genenames.org 7.670E-3 1.023E-2 2.780E-2
6.136E-2
 1 10
7 818 Syntaxins genenames.org 1.225E-2 1.400E-2 3.804E-2
9.797E-2
 1 16
8 823 C2 domain containing|Calpains genenames.org 2.736E-2 2.736E-2
7.435E-2
2.189E-1
 1 36
Show 3 more annotations

13: Coexpression [Display Chart] 17 input genes in category / 1418 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16587 Genes up-regulated in primary granulosa cells after stimulation with LH or FSH gonadotrophic hormones for 24 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.846E-5 3.507E-2
2.748E-1
5.453E-2
 3 91
2 M2846 Genes down-regulated in MCF10A cells vs knockdown of EIF4G1 [Gene ID=1981] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 4.947E-5 3.507E-2
2.748E-1
7.015E-2
 3 99
3 M1637 Top 20 positive significant genes associated with leiomyosarcoma tumors expressing muscle gene cluster with CNN1 [GeneID=1264]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.625E-5 4.077E-2
3.194E-1
1.223E-1
 2 19

14: Coexpression Atlas [Display Chart] 17 input genes in category / 1123 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 250 F-vs-M DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 F-vs-M top280 280 Gudmap Mouse MOE430.2 4.205E-5 4.722E-2
3.590E-1
 4.722E-2 4 261
2 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap 8.411E-5 4.723E-2
3.590E-1
9.446E-2
 4 312

15: Computational [Display Chart] 14 input genes in category / 68 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12229 MODULE 381 Genes in the cancer module 381. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.183E-4 5.878E-3 2.824E-2 8.044E-3 2 12
2 M18480 MODULE 159 Translation regulation. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.729E-4 5.878E-3 2.824E-2 1.176E-2 3 81
3 M13925 MODULE 86 Small monomeric GTPases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.579E-3 3.579E-2
1.719E-1
1.074E-1
 2 43
4 M9350 MORF RAB1A Neighborhood of RAB1A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.212E-3 3.760E-2
1.806E-1
1.504E-1
 3 194

16: MicroRNA [Display Chart] 17 input genes in category / 848 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GGGACCA,MIR-133B:MSigDB GGGACCA,MIR-133B:MSigDB MSigDB 1.074E-7 4.554E-5 3.334E-4 9.109E-5 4 190
2 GGGACCA,MIR-133A:MSigDB GGGACCA,MIR-133A:MSigDB MSigDB 1.074E-7 4.554E-5 3.334E-4 9.109E-5 4 190
3 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 7.193E-7 2.033E-4 1.488E-3 6.100E-4 4 306
4 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 2.385E-6 5.056E-4 3.702E-3 2.023E-3 4 414
5 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 3.089E-6 5.239E-4 3.835E-3 2.620E-3 4 442
6 hsa-miR-490-3p:TargetScan hsa-miR-490-3p TargetScan 7.771E-6 1.038E-3 7.600E-3 6.590E-3 3 165
7 hsa-miR-1226:PITA hsa-miR-1226:PITA TOP PITA 1.008E-5 1.038E-3 7.600E-3 8.550E-3 3 180
8 hsa-miR-584:PITA hsa-miR-584:PITA TOP PITA 1.094E-5 1.038E-3 7.600E-3 9.279E-3 3 185
9 AAAGGGA,MIR-204:MSigDB AAAGGGA,MIR-204:MSigDB MSigDB 1.621E-5 1.038E-3 7.600E-3 1.374E-2 3 211
10 AAAGGGA,MIR-211:MSigDB AAAGGGA,MIR-211:MSigDB MSigDB 1.621E-5 1.038E-3 7.600E-3 1.374E-2 3 211
11 hsa-miR-612:PITA hsa-miR-612:PITA TOP PITA 1.690E-5 1.038E-3 7.600E-3 1.433E-2 3 214
12 hsa-miR-1285:PITA hsa-miR-1285:PITA TOP PITA 1.690E-5 1.038E-3 7.600E-3 1.433E-2 3 214
13 hsa-miR-329:PITA hsa-miR-329:PITA TOP PITA 1.714E-5 1.038E-3 7.600E-3 1.454E-2 3 215
14 hsa-miR-362-3p:PITA hsa-miR-362-3p:PITA TOP PITA 1.714E-5 1.038E-3 7.600E-3 1.454E-2 3 215
15 hsa-miR-451a:Functional MTI Functional MTI miRTarbase 2.414E-5 1.365E-3 9.990E-3 2.047E-2 2 31
16 hsa-miR-622:PITA hsa-miR-622:PITA TOP PITA 2.592E-5 1.374E-3 1.006E-2 2.198E-2 3 247
17 hsa-miR-18a-5p:Functional MTI Functional MTI miRTarbase 3.088E-5 1.541E-3 1.128E-2 2.619E-2 3 262
18 hsa-miR-634:PITA hsa-miR-634:PITA TOP PITA 3.452E-5 1.626E-3 1.191E-2 2.927E-2 3 272
19 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 5.854E-5 2.424E-3 1.775E-2 4.964E-2 3 325
20 hsa-miR-488:PITA hsa-miR-488:PITA TOP PITA 5.908E-5 2.424E-3 1.775E-2
5.010E-2
 3 326
21 hsa-miR-338-3p:TargetScan hsa-miR-338-3p TargetScan 6.291E-5 2.424E-3 1.775E-2
5.335E-2
 3 333
22 hsa-miR-578:PITA hsa-miR-578:PITA TOP PITA 6.518E-5 2.424E-3 1.775E-2
5.527E-2
 3 337
23 hsa-miR-216b:PITA hsa-miR-216b:PITA TOP PITA 6.575E-5 2.424E-3 1.775E-2
5.576E-2
 3 338
24 hsa-miR-499-3p:PITA hsa-miR-499-3p:PITA TOP PITA 6.986E-5 2.469E-3 1.807E-2
5.924E-2
 3 345
25 hsa-miR-1271:PITA hsa-miR-1271:PITA TOP PITA 7.666E-5 2.542E-3 1.861E-2
6.501E-2
 3 356
26 hsa-miR-96:PITA hsa-miR-96:PITA TOP PITA 7.794E-5 2.542E-3 1.861E-2
6.609E-2
 3 358
27 hsa-miR-583:PITA hsa-miR-583:PITA TOP PITA 9.152E-5 2.874E-3 2.104E-2
7.761E-2
 3 378
28 hsa-miR-130a-3p:Functional MTI Functional MTI miRTarbase 1.066E-4 3.227E-3 2.363E-2
9.036E-2
 3 398
29 hsa-miR-485-3p:PITA hsa-miR-485-3p:PITA TOP PITA 1.266E-4 3.463E-3 2.535E-2
1.074E-1
 3 422
30 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 1.329E-4 3.463E-3 2.535E-2
1.127E-1
 3 429
31 hsa-miR-525-3p:mirSVR lowEffct hsa-miR-525-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.338E-4 3.463E-3 2.535E-2
1.135E-1
 3 430
32 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 1.348E-4 3.463E-3 2.535E-2
1.143E-1
 3 431
33 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 1.348E-4 3.463E-3 2.535E-2
1.143E-1
 3 431
34 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.413E-4 3.484E-3 2.550E-2
1.198E-1
 3 438
35 hsa-miR-1201:PITA hsa-miR-1201:PITA TOP PITA 1.509E-4 3.484E-3 2.550E-2
1.280E-1
 2 77
36 hsa-miR-135a:PITA hsa-miR-135a:PITA TOP PITA 1.520E-4 3.484E-3 2.550E-2
1.289E-1
 3 449
37 hsa-miR-135b:PITA hsa-miR-135b:PITA TOP PITA 1.520E-4 3.484E-3 2.550E-2
1.289E-1
 3 449
38 hsa-miR-1915*:mirSVR highEffct hsa-miR-1915*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.643E-4 3.558E-3 2.604E-2
1.393E-1
 3 461
39 hsa-miR-139-3p:mirSVR lowEffct hsa-miR-139-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.760E-4 3.558E-3 2.604E-2
1.493E-1
 3 472
40 hsa-miR-379-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.796E-4 3.558E-3 2.604E-2
1.523E-1
 2 84
41 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 1.850E-4 3.558E-3 2.604E-2
1.568E-1
 3 480
42 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 1.918E-4 3.558E-3 2.604E-2
1.627E-1
 3 486
43 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 1.930E-4 3.558E-3 2.604E-2
1.636E-1
 3 487
44 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 1.930E-4 3.558E-3 2.604E-2
1.636E-1
 3 487
45 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 1.930E-4 3.558E-3 2.604E-2
1.636E-1
 3 487
46 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 1.930E-4 3.558E-3 2.604E-2
1.636E-1
 3 487
47 hsa-miR-3065-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.191E-4 5.757E-3 4.215E-2
2.706E-1
 2 112
48 hsa-miR-383:PITA hsa-miR-383:PITA TOP PITA 4.766E-4 8.419E-3
6.164E-2
4.041E-1
 2 137
49 hsa-miR-632:PITA hsa-miR-632:PITA TOP PITA 4.905E-4 8.489E-3
6.214E-2
4.159E-1
 2 139
50 hsa-miR-134-5p:TargetScan hsa-miR-134-5p TargetScan 5.118E-4 8.680E-3
6.354E-2
4.340E-1
 2 142
Show 45 more annotations

17: Drug [Display Chart] 17 input genes in category / 3642 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000077802 3-chlorobenzylamine Stitch 4.041E-11 1.472E-7 1.292E-6 1.472E-7 6 91
2 CID000052999 metsulfuron-methyl Stitch 1.805E-6 3.287E-3 2.885E-2 6.574E-3 4 123
3 CID000123278 plumbane Stitch 1.871E-5 2.272E-2
1.994E-1
6.815E-2
 2 9
4 CID000445279 AC1L9HPX Stitch 4.263E-5 3.304E-2
2.900E-1
1.553E-1
 3 93
5 CID000157561 augustine Stitch 4.720E-5 3.304E-2
2.900E-1
1.719E-1
 2 14
6 CID009549801 GSVs Stitch 5.443E-5 3.304E-2
2.900E-1
1.983E-1
 2 15
7 ctd:D005031 Ethylenethiourea CTD 3.058E-4 4.156E-2
3.648E-1
1.000E0
 2 35
8 1663 DN ICI 182,780; Down 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.117E-4 4.156E-2
3.648E-1
1.000E0
 3 182
9 CID000003417 fosphomycin Stitch 3.608E-4 4.156E-2
3.648E-1
1.000E0
 2 38
10 CID000004122 nocodazole Stitch 3.630E-4 4.156E-2
3.648E-1
1.000E0
 4 478
11 629 UP 2-propylpentanoic acid; Up 200; 1000uM; SKMEL5; HG-U133A Broad Institute CMAP Up 3.645E-4 4.156E-2
3.648E-1
1.000E0
 3 192
12 1988 UP Captopril [62571-86-2]; Up 200; 17.2uM; HL60; HG-U133A Broad Institute CMAP Up 3.701E-4 4.156E-2
3.648E-1
1.000E0
 3 193
13 4690 DN Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.701E-4 4.156E-2
3.648E-1
1.000E0
 3 193
14 5457 DN Naproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.758E-4 4.156E-2
3.648E-1
1.000E0
 3 194
15 6811 DN Sertaconazole nitrate [99592-39-9]; Down 200; 8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.758E-4 4.156E-2
3.648E-1
1.000E0
 3 194
16 843 UP 5279552; Up 200; 22uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 3.815E-4 4.156E-2
3.648E-1
1.000E0
 3 195
17 2475 DN Benperidol [2062-84-2]; Down 200; 10.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 3.815E-4 4.156E-2
3.648E-1
1.000E0
 3 195
18 5474 UP Norethindrone [68-22-4]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.815E-4 4.156E-2
3.648E-1
1.000E0
 3 195
19 3859 DN Indapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.815E-4 4.156E-2
3.648E-1
1.000E0
 3 195
20 6021 UP Pentoxifylline [6493-05-6]; Up 200; 14.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
21 5947 UP radicicol; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
22 2249 DN Ampyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
23 7276 UP Disopyramide [3737-09-5]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
24 3844 DN Spiramycin [8025-81-8]; Down 200; 4.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
25 3830 DN Solasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
26 4734 DN Flumethasone [2135-17-3]; Down 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.872E-4 4.156E-2
3.648E-1
1.000E0
 3 196
27 7264 UP Clorsulon [60200-06-8]; Up 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.930E-4 4.156E-2
3.648E-1
1.000E0
 3 197
28 4226 UP Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.930E-4 4.156E-2
3.648E-1
1.000E0
 3 197
29 3896 UP Tinidazole [19387-91-8]; Up 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.930E-4 4.156E-2
3.648E-1
1.000E0
 3 197
30 6824 DN Napelline [5008-52-6]; Down 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.930E-4 4.156E-2
3.648E-1
1.000E0
 3 197
31 3832 DN Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.930E-4 4.156E-2
3.648E-1
1.000E0
 3 197
32 7101 DN GSK-3 Inhibitor IX; Down 200; 0.5uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.930E-4 4.156E-2
3.648E-1
1.000E0
 3 197
33 7144 DN Ramipril [87333-19-5]; Down 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.989E-4 4.156E-2
3.648E-1
1.000E0
 3 198
34 1277 UP Oxantel pamoate [68813-55-8]; Up 200; 6.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.048E-4 4.156E-2
3.648E-1
1.000E0
 3 199
35 3548 DN Natamycin [7681-93-8]; Down 200; 6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.048E-4 4.156E-2
3.648E-1
1.000E0
 3 199
36 4725 DN Folinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.108E-4 4.156E-2
3.648E-1
1.000E0
 3 200
Show 31 more annotations

18: Disease [Display Chart] 16 input genes in category / 365 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0151468 Thyroid Gland Follicular Adenoma DisGeNET Curated 1.472E-4 2.772E-2
1.796E-1
5.374E-2
 3 107
2 cv:CN221135 Diabetes mellitus, noninsulin-dependent, 5 Clinical Variations 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
3 C4024054 Duplication of the proximal phalanx of the hallux DisGeNET Curated 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
4 C1860156 Lateral displacement of patellae DisGeNET Curated 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
5 C0730330 Chloroquine retinopathy DisGeNET Curated 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
6 OMIN:603649 CONE-ROD DYSTROPHY 7; CORD7 OMIM 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
7 C4023926 Pseudoepiphyses of the proximal phalanges of the hand DisGeNET Curated 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
8 OMIN:201000 CARPENTER SYNDROME OMIM 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
9 C4024273 Complete duplication of proximal phalanx of the thumb DisGeNET Curated 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
10 cv:C1275078 Carpenter syndrome 1 Clinical Variations 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
11 cv:C1863634 Cone-rod dystrophy 7 Clinical Variations 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
12 OMIN:600882 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B; CMT2B OMIM 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
13 cv:C1833219 Charcot-Marie-Tooth disease type 2B Clinical Variations 9.873E-4 2.772E-2
1.796E-1
3.604E-1
 1 1
14 C0175702 Williams Syndrome DisGeNET Curated 1.723E-3 3.602E-2
2.334E-1
6.290E-1
 2 63
15 C0600427 Cocaine Dependence DisGeNET Curated 1.947E-3 3.602E-2
2.334E-1
7.105E-1
 2 67
16 C1828210 Macular dystrophy, concentric annular DisGeNET Curated 1.974E-3 3.602E-2
2.334E-1
7.204E-1
 1 2
17 C0686625 Secondary malignant neoplasm of lymph nodes of neck DisGeNET BeFree 1.974E-3 3.602E-2
2.334E-1
7.204E-1
 1 2
18 C4025737 Osteomyelitis or necrosis, distal, due to sensory neuropathy (feet) DisGeNET Curated 1.974E-3 3.602E-2
2.334E-1
7.204E-1
 1 2
19 C0015458 Facial Hemiatrophy DisGeNET BeFree 1.974E-3 3.602E-2
2.334E-1
7.204E-1
 1 2
20 C4025740 Autoamputation of foot DisGeNET Curated 1.974E-3 3.602E-2
2.334E-1
7.204E-1
 1 2
21 C2112942 Preaxial foot polydactyly DisGeNET Curated 2.959E-3 4.690E-2
3.038E-1
1.000E0
 1 3
22 C1275078 Acrocephalopolysyndactyly type 2 DisGeNET Curated 2.959E-3 4.690E-2
3.038E-1
1.000E0
 1 3
23 C1866339 Preaxial Hallucal Polydactyly DisGeNET Curated 2.959E-3 4.690E-2
3.038E-1
1.000E0
 1 3
24 C4025619 Peripheral axonal atrophy DisGeNET Curated 3.944E-3 4.690E-2
3.038E-1
1.000E0
 1 4
25 C1863634 Cone-Rod Dystrophy 7 DisGeNET Curated 3.944E-3 4.690E-2
3.038E-1
1.000E0
 1 4
26 C0238410 Renal Pelvis Urothelial Carcinoma DisGeNET BeFree 3.944E-3 4.690E-2
3.038E-1
1.000E0
 1 4
27 C1865371 SEVERE COMBINED IMMUNODEFICIENCY, ATHABASKAN-TYPE DisGeNET Curated 3.944E-3 4.690E-2
3.038E-1
1.000E0
 1 4
28 C1862152 Short to absent middle phalanges DisGeNET Curated 4.928E-3 4.690E-2
3.038E-1
1.000E0
 1 5
29 C1833321 CHORIORETINAL ATROPHY, PROGRESSIVE BIFOCAL DisGeNET Curated 4.928E-3 4.690E-2
3.038E-1
1.000E0
 1 5
30 C4023976 Aplasia/Hypoplasia of the middle phalanges of the toes DisGeNET Curated 4.928E-3 4.690E-2
3.038E-1
1.000E0
 1 5
31 C1860796 Shallow acetabulum DisGeNET Curated 4.928E-3 4.690E-2
3.038E-1
1.000E0
 1 5
32 C1854910 Shallow acetabular fossae DisGeNET Curated 4.928E-3 4.690E-2
3.038E-1
1.000E0
 1 5
33 C0085084 Motor Neuron Disease DisGeNET Curated 5.805E-3 4.690E-2
3.038E-1
1.000E0
 2 117
34 C2129214 Loose stool DisGeNET BeFree 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
35 C0151594 Hemorrhagic diarrhea DisGeNET BeFree 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
36 C1844508 Large foramen magnum DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
37 C4280564 Cloverleaf cranium shape DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
38 C4280554 Increased diameter of foramen magnum DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
39 C4280555 Increased circumference of foramen magnum DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
40 C0476122 ovarian serous tumor DisGeNET BeFree 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
41 C1833219 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B (disorder) DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
42 C1290511 Anodontia of Permanent Dentition DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
43 C1855670 Corneal abnormalities DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
44 C4073291 Hyperplasia of foramen magnum DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
45 C0457756 Tooth absent DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
46 C4020889 Cornela disease DisGeNET Curated 5.910E-3 4.690E-2
3.038E-1
1.000E0
 1 6
47 C0035372 Rett Syndrome DisGeNET Curated 6.805E-3 4.838E-2
3.134E-1
1.000E0
 2 127
48 C1968790 Axonal degeneration/regeneration DisGeNET Curated 6.892E-3 4.838E-2
3.134E-1
1.000E0
 1 7
49 C0423414 Retinal flecking DisGeNET Curated 6.892E-3 4.838E-2
3.134E-1
1.000E0
 1 7
50 C1856659 Polysplenia DisGeNET Curated 6.892E-3 4.838E-2
3.134E-1
1.000E0
 1 7
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