|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
21072166
|
PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.
|
Pubmed
|
3.932E-37
|
5.726E-34
|
4.501E-33
|
5.726E-34
|
11
|
13
|
2
|
9013886
|
Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.
|
Pubmed
|
1.835E-36
|
8.905E-34
|
7.000E-33
|
2.672E-33
|
11
|
14
|
3
|
9400615
|
Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.
|
Pubmed
|
1.835E-36
|
8.905E-34
|
7.000E-33
|
2.672E-33
|
11
|
14
|
4
|
21351466
|
[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].
|
Pubmed
|
6.235E-35
|
1.816E-32
|
1.427E-31
|
9.079E-32
|
11
|
17
|
5
|
17266553
|
Regulation of HIV-1 transcription by protein phosphatase 1.
|
Pubmed
|
6.235E-35
|
1.816E-32
|
1.427E-31
|
9.079E-32
|
11
|
17
|
6
|
23287597
|
Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.
|
Pubmed
|
1.603E-34
|
3.890E-32
|
3.058E-31
|
2.334E-31
|
11
|
18
|
7
|
11531413
|
HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.
|
Pubmed
|
6.558E-32
|
1.364E-29
|
1.072E-28
|
9.548E-29
|
11
|
27
|
8
|
18782753
|
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
|
Pubmed
|
6.689E-29
|
1.217E-26
|
9.570E-26
|
9.739E-26
|
11
|
46
|
9
|
16541025
|
Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
|
Pubmed
|
9.414E-27
|
1.523E-24
|
1.197E-23
|
1.371E-23
|
9
|
19
|
10
|
16541024
|
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
|
Pubmed
|
1.929E-25
|
2.808E-23
|
2.207E-22
|
2.808E-22
|
8
|
12
|
11
|
18971272
|
Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
|
Pubmed
|
5.013E-25
|
6.635E-23
|
5.216E-22
|
7.299E-22
|
8
|
13
|
12
|
7592815
|
Identification of a new family of protein phosphatase 2A regulatory subunits.
|
Pubmed
|
1.354E-24
|
1.516E-22
|
1.192E-21
|
1.971E-21
|
7
|
7
|
13
|
8703017
|
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.
|
Pubmed
|
1.354E-24
|
1.516E-22
|
1.192E-21
|
1.971E-21
|
7
|
7
|
14
|
15380617
|
Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.
|
Pubmed
|
1.071E-21
|
1.114E-19
|
8.754E-19
|
1.559E-18
|
7
|
12
|
15
|
16048649
|
Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.
|
Pubmed
|
4.638E-21
|
4.502E-19
|
3.539E-18
|
6.753E-18
|
7
|
14
|
16
|
12370081
|
Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.
|
Pubmed
|
1.206E-19
|
1.097E-17
|
8.624E-17
|
1.755E-16
|
6
|
8
|
17
|
17540176
|
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
|
Pubmed
|
4.528E-18
|
3.878E-16
|
3.049E-15
|
6.593E-15
|
7
|
32
|
18
|
8694763
|
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.
|
Pubmed
|
1.265E-17
|
9.698E-16
|
7.623E-15
|
1.843E-14
|
5
|
5
|
19
|
8812429
|
Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.
|
Pubmed
|
1.265E-17
|
9.698E-16
|
7.623E-15
|
1.843E-14
|
5
|
5
|
20
|
9847399
|
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.
|
Pubmed
|
7.591E-17
|
5.526E-15
|
4.344E-14
|
1.105E-13
|
5
|
6
|
21
|
19156129
|
An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
|
Pubmed
|
1.242E-16
|
8.612E-15
|
6.770E-14
|
1.808E-13
|
8
|
107
|
22
|
11007961
|
Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.
|
Pubmed
|
7.081E-16
|
4.686E-14
|
3.684E-13
|
1.031E-12
|
5
|
8
|
23
|
16456541
|
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.
|
Pubmed
|
1.593E-15
|
1.008E-13
|
7.926E-13
|
2.319E-12
|
5
|
9
|
24
|
23555304
|
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
|
Pubmed
|
1.393E-14
|
8.451E-13
|
6.644E-12
|
2.028E-11
|
6
|
39
|
25
|
11929880
|
Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits.
|
Pubmed
|
3.452E-14
|
1.862E-12
|
1.463E-11
|
5.026E-11
|
4
|
4
|
26
|
15095873
|
Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice.
|
Pubmed
|
3.452E-14
|
1.862E-12
|
1.463E-11
|
5.026E-11
|
4
|
4
|
27
|
28174209
|
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
|
Pubmed
|
3.452E-14
|
1.862E-12
|
1.463E-11
|
5.026E-11
|
4
|
4
|
28
|
18596935
|
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.
|
Pubmed
|
1.725E-13
|
8.374E-12
|
6.583E-11
|
2.512E-10
|
4
|
5
|
29
|
11591705
|
Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
|
Pubmed
|
1.725E-13
|
8.374E-12
|
6.583E-11
|
2.512E-10
|
4
|
5
|
30
|
10629059
|
PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
|
Pubmed
|
1.725E-13
|
8.374E-12
|
6.583E-11
|
2.512E-10
|
4
|
5
|
31
|
21172653
|
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
|
Pubmed
|
5.175E-13
|
2.355E-11
|
1.851E-10
|
7.535E-10
|
4
|
6
|
32
|
19915589
|
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
|
Pubmed
|
5.175E-13
|
2.355E-11
|
1.851E-10
|
7.535E-10
|
4
|
6
|
33
|
10698523
|
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
|
Pubmed
|
1.207E-12
|
5.326E-11
|
4.187E-10
|
1.758E-9
|
4
|
7
|
34
|
17245430
|
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
|
Pubmed
|
2.414E-12
|
9.248E-11
|
7.270E-10
|
3.514E-9
|
4
|
8
|
35
|
18432318
|
Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
|
Pubmed
|
2.414E-12
|
9.248E-11
|
7.270E-10
|
3.514E-9
|
4
|
8
|
36
|
12912990
|
Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.
|
Pubmed
|
2.414E-12
|
9.248E-11
|
7.270E-10
|
3.514E-9
|
4
|
8
|
37
|
26280018
|
PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor.
|
Pubmed
|
2.414E-12
|
9.248E-11
|
7.270E-10
|
3.514E-9
|
4
|
8
|
38
|
11956189
|
Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.
|
Pubmed
|
2.414E-12
|
9.248E-11
|
7.270E-10
|
3.514E-9
|
4
|
8
|
39
|
14645548
|
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.
|
Pubmed
|
4.343E-12
|
1.621E-10
|
1.275E-9
|
6.324E-9
|
4
|
9
|
40
|
22422068
|
Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.
|
Pubmed
|
5.466E-12
|
1.941E-10
|
1.526E-9
|
7.959E-9
|
5
|
37
|
41
|
26811472
|
Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.
|
Pubmed
|
5.466E-12
|
1.941E-10
|
1.526E-9
|
7.959E-9
|
5
|
37
|
42
|
21242291
|
RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.
|
Pubmed
|
7.236E-12
|
2.509E-10
|
1.972E-9
|
1.054E-8
|
4
|
10
|
43
|
12435421
|
Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
|
Pubmed
|
1.705E-11
|
5.772E-10
|
4.538E-9
|
2.482E-8
|
4
|
12
|
44
|
16717086
|
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.
|
Pubmed
|
2.462E-11
|
8.146E-10
|
6.403E-9
|
3.584E-8
|
4
|
13
|
45
|
21514445
|
Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.
|
Pubmed
|
6.260E-11
|
2.026E-9
|
1.592E-8
|
9.115E-8
|
4
|
16
|
46
|
17174897
|
Structure of the protein phosphatase 2A holoenzyme.
|
Pubmed
|
8.789E-11
|
2.559E-9
|
2.012E-8
|
1.280E-7
|
3
|
3
|
47
|
17105772
|
The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.
|
Pubmed
|
8.789E-11
|
2.559E-9
|
2.012E-8
|
1.280E-7
|
3
|
3
|
48
|
10375619
|
Characterization of the components of the putative mammalian sister chromatid cohesion complex.
|
Pubmed
|
8.789E-11
|
2.559E-9
|
2.012E-8
|
1.280E-7
|
3
|
3
|
49
|
8392071
|
Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.
|
Pubmed
|
8.789E-11
|
2.559E-9
|
2.012E-8
|
1.280E-7
|
3
|
3
|
50
|
25972378
|
Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
|
Pubmed
|
8.789E-11
|
2.559E-9
|
2.012E-8
|
1.280E-7
|
3
|
3
|