Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc80_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 13 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019783 ubiquitin-like protein-specific protease activity 1.410E-3 1.566E-2 4.980E-2 1.833E-2 2 119
2 GO:0019784 NEDD8-specific protease activity 2.409E-3 1.566E-2 4.980E-2 3.132E-2 1 5
3 GO:0008234 cysteine-type peptidase activity 3.954E-3 1.713E-2
5.449E-2
5.140E-2
 2 201

2: GO: Biological Process [Display Chart] 9 input genes in category / 46 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000338 protein deneddylation 1.130E-27 5.199E-26 2.296E-25 5.199E-26 8 10
2 GO:0000715 nucleotide-excision repair, DNA damage recognition 1.231E-23 2.831E-22 1.250E-21 5.662E-22 8 23
3 GO:0006283 transcription-coupled nucleotide-excision repair 3.366E-19 5.161E-18 2.280E-17 1.548E-17 8 73
4 GO:0006289 nucleotide-excision repair 1.960E-17 2.254E-16 9.953E-16 9.014E-16 8 119
5 GO:0070646 protein modification by small protein removal 7.901E-17 7.269E-16 3.210E-15 3.634E-15 8 141
6 GO:0010387 COP9 signalosome assembly 1.932E-3 1.481E-2
6.541E-2
8.887E-2
 1 4
7 GO:1903894 regulation of IRE1-mediated unfolded protein response 6.266E-3 3.603E-2
1.591E-1
2.883E-1
 1 13
8 GO:0045116 protein neddylation 6.266E-3 3.603E-2
1.591E-1
2.883E-1
 1 13
9 GO:1990182 exosomal secretion 1.011E-2 4.869E-2
2.150E-1
4.648E-1
 1 21
10 GO:0007250 activation of NF-kappaB-inducing kinase activity 1.058E-2 4.869E-2
2.150E-1
4.869E-1
 1 22
Show 5 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 7 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008180 COP9 signalosome 3.782E-22 2.647E-21 6.865E-21 2.647E-21 8 34
2 GO:0008021 synaptic vesicle 2.307E-3 6.523E-3 1.691E-2 1.615E-2 2 156
3 GO:0070382 exocytic vesicle 2.796E-3 6.523E-3 1.691E-2 1.957E-2 2 172
4 GO:0005852 eukaryotic translation initiation factor 3 complex 7.531E-3 1.318E-2 3.417E-2
5.272E-2
 1 16
5 GO:0098793 presynapse 1.057E-2 1.472E-2 3.817E-2
7.401E-2
 2 341
6 GO:0030133 transport vesicle 1.262E-2 1.472E-2 3.817E-2
8.833E-2
 2 374
Show 1 more annotation

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 105 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001696 failure to gastrulate 4.099E-4 2.174E-2
1.138E-1
 4.304E-2 2 55
2 MP:0004966 abnormal inner cell mass proliferation 6.266E-4 2.174E-2
1.138E-1
6.580E-2
 2 68
3 MP:0002718 abnormal inner cell mass morphology 9.103E-4 2.174E-2
1.138E-1
9.558E-2
 2 82
4 MP:0011091 prenatal lethality, complete penetrance 1.080E-3 2.174E-2
1.138E-1
1.134E-1
 3 404
5 MP:0013589 thymus medulla hypoplasia 1.159E-3 2.174E-2
1.138E-1
1.217E-1
 1 2
6 MP:0006413 increased T cell apoptosis 1.432E-3 2.174E-2
1.138E-1
1.504E-1
 2 103
7 MP:0009850 embryonic lethality between implantation and placentation 1.449E-3 2.174E-2
1.138E-1
1.522E-1
 3 447
8 MP:0006206 embryonic lethality between somite formation and embryo turning 1.875E-3 2.460E-2
1.288E-1
1.968E-1
 2 118
9 MP:0004503 decreased incidence of tumors by ionizing radiation induction 2.316E-3 2.702E-2
1.415E-1
2.432E-1
 1 4
10 MP:0006412 abnormal T cell apoptosis 2.970E-3 3.119E-2
1.633E-1
3.119E-1
 2 149
11 MP:0010039 abnormal trophoblast giant cell proliferation 3.472E-3 3.315E-2
1.735E-1
3.646E-1
 1 6
12 MP:0014137 abnormal preimplantation embryo morphology 5.711E-3 4.613E-2
2.415E-1
5.997E-1
 2 208
13 MP:0004957 abnormal blastocyst morphology 5.711E-3 4.613E-2
2.415E-1
5.997E-1
 2 208
Show 8 more annotations

6: Domain [Display Chart] 9 input genes in category / 25 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00088 PINT SMART 2.857E-14 3.373E-13 1.287E-12 7.143E-13 5 16
2 IPR000717 PCI dom InterPro 4.047E-14 3.373E-13 1.287E-12 1.012E-12 5 17
3 PF01399 PCI Pfam 4.047E-14 3.373E-13 1.287E-12 1.012E-12 5 17
4 PF10075 CSN8 PSD8 EIF3K Pfam 1.230E-6 7.689E-6 2.934E-5 3.076E-5 2 4
5 SM00232 JAB MPN SMART 1.351E-5 4.823E-5 1.841E-4 3.376E-4 2 12
6 PF01398 JAB Pfam 1.351E-5 4.823E-5 1.841E-4 3.376E-4 2 12
7 IPR000555 JAMM/MPN+ dom InterPro 1.351E-5 4.823E-5 1.841E-4 3.376E-4 2 12
8 1.10.10.10 - Gene3D 1.240E-4 3.874E-4 1.478E-3 3.099E-3 3 218
9 IPR011990 TPR-like helical dom InterPro 1.529E-4 4.246E-4 1.620E-3 3.821E-3 3 234
10 IPR011991 WHTH DNA-bd dom InterPro 1.709E-4 4.272E-4 1.630E-3 4.272E-3 3 243
11 IPR027530 Csn7b InterPro 4.804E-4 9.238E-4 3.525E-3 1.201E-2 1 1
12 IPR033205 COP9 CSN8 InterPro 4.804E-4 9.238E-4 3.525E-3 1.201E-2 1 1
13 IPR033859 MPN CSN6 InterPro 4.804E-4 9.238E-4 3.525E-3 1.201E-2 1 1
14 IPR033464 CSN8 PSD8 EIF3K InterPro 1.441E-3 2.572E-3 9.816E-3 3.601E-2 1 3
15 PF13012 MitMem reg Pfam 1.920E-3 3.000E-3 1.145E-2 4.801E-2 1 4
16 IPR024969 Rpn11/EIF3F C InterPro 1.920E-3 3.000E-3 1.145E-2 4.801E-2 1 4
17 IPR019954 Ubiquitin CS InterPro 4.795E-3 7.051E-3 2.691E-2
1.199E-1
 1 10
18 IPR019956 Ubiquitin InterPro 5.273E-3 7.324E-3 2.795E-2
1.318E-1
 1 11
19 PS00299 UBIQUITIN 1 PROSITE 1.764E-2 2.321E-2
8.856E-2
4.410E-1
 1 37
20 SM00213 UBQ SMART 2.047E-2 2.559E-2
9.765E-2
5.118E-1
 1 43
21 PF00240 ubiquitin Pfam 2.236E-2 2.662E-2
1.016E-1
5.589E-1
 1 47
22 PS50053 UBIQUITIN 2 PROSITE 2.565E-2 2.915E-2
1.112E-1
6.412E-1
 1 54
23 IPR000626 Ubiquitin dom InterPro 2.753E-2 2.992E-2
1.142E-1
6.881E-1
 1 58
Show 18 more annotations

7: Pathway [Display Chart] 9 input genes in category / 19 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1309113 DNA Damage Recognition in GG-NER BioSystems: REACTOME 3.868E-20 7.349E-19 2.607E-18 7.349E-19 8 39
2 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 8.766E-20 8.328E-19 2.954E-18 1.666E-18 9 99
3 1309118 Formation of TC-NER Pre-Incision Complex BioSystems: REACTOME 6.534E-19 4.138E-18 1.468E-17 1.241E-17 8 54
4 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 1.814E-18 8.617E-18 3.057E-17 3.447E-17 9 137
5 1309117 Transcription-Coupled Nucleotide Excision Repair (TC-NER) BioSystems: REACTOME 1.635E-17 6.215E-17 2.205E-16 3.107E-16 8 79
6 1309112 Global Genome Nucleotide Excision Repair (GG-NER) BioSystems: REACTOME 3.015E-17 9.549E-17 3.388E-16 5.729E-16 8 85
7 1309111 Nucleotide Excision Repair BioSystems: REACTOME 2.974E-16 8.071E-16 2.863E-15 5.650E-15 8 112
8 1270350 DNA Repair BioSystems: REACTOME 1.500E-12 3.562E-12 1.264E-11 2.849E-11 8 319
9 PW:0000415 proteasome degradation involving cullin-dependent ubiquitin ligases Pathway Ontology 7.926E-3 1.506E-2
5.343E-2
1.506E-1
 1 11
10 PW:0000435 neddylation Pathway Ontology 7.926E-3 1.506E-2
5.343E-2
1.506E-1
 1 11
11 M17977 Regulation of p27 Phosphorylation during Cell Cycle Progression MSigDB C2 BIOCARTA (v6.0) 9.361E-3 1.578E-2
5.597E-2
1.779E-1
 1 13
12 M13324 Hypoxia-Inducible Factor in the Cardiovascular System MSigDB C2 BIOCARTA (v6.0) 1.079E-2 1.578E-2
5.597E-2
2.051E-1
 1 15
13 138056 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha BioSystems: Pathway Interaction Database 1.079E-2 1.578E-2
5.597E-2
2.051E-1
 1 15
14 1269524 TGF-beta receptor signaling activates SMADs BioSystems: REACTOME 2.432E-2 3.300E-2
1.171E-1
4.621E-1
 1 34
Show 9 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 568 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9707402 The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Pubmed 7.218E-31 4.100E-28 2.837E-27 4.100E-28 8 9
2 19141280 Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Pubmed 3.609E-30 1.025E-27 7.093E-27 2.050E-27 8 10
3 12220626 Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. Pubmed 1.323E-29 1.879E-27 1.300E-26 7.516E-27 8 11
4 11285227 COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Pubmed 1.323E-29 1.879E-27 1.300E-26 7.516E-27 8 11
5 20399188 Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3. Pubmed 3.970E-29 4.510E-27 3.121E-26 2.255E-26 8 12
6 16964240 Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Pubmed 5.892E-29 5.577E-27 3.860E-26 3.346E-26 9 32
7 27833851 Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation. Pubmed 1.032E-28 8.375E-27 5.796E-26 5.863E-26 8 13
8 29089422 A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Pubmed 1.977E-28 1.368E-26 9.466E-26 1.123E-25 9 36
9 12732143 The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Pubmed 2.408E-28 1.368E-26 9.466E-26 1.368E-25 8 14
10 18606781 Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Pubmed 2.408E-28 1.368E-26 9.466E-26 1.368E-25 8 14
11 12628923 Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. Pubmed 5.160E-28 2.665E-26 1.844E-25 2.931E-25 8 15
12 14647295 The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? Pubmed 1.531E-27 6.691E-26 4.630E-25 8.698E-25 7 7
13 10782111 Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Pubmed 1.531E-27 6.691E-26 4.630E-25 8.698E-25 7 7
14 9535219 A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. Pubmed 1.225E-26 4.349E-25 3.010E-24 6.958E-24 7 8
15 25043011 Crystal structure of the human COP9 signalosome. Pubmed 1.225E-26 4.349E-25 3.010E-24 6.958E-24 7 8
16 12615944 Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Pubmed 1.225E-26 4.349E-25 3.010E-24 6.958E-24 7 8
17 11337588 Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Pubmed 1.632E-26 5.452E-25 3.773E-24 9.268E-24 8 21
18 19295130 An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. Pubmed 2.639E-26 8.329E-25 5.764E-24 1.499E-23 9 59
19 22414063 Purification of the COP9 signalosome complex and binding partners from human T cells. Pubmed 1.837E-25 5.493E-24 3.801E-23 1.044E-22 7 10
20 24292625 Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Pubmed 4.692E-25 1.333E-23 9.221E-23 2.665E-22 8 30
21 11704659 The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Pubmed 5.053E-25 1.367E-23 9.457E-23 2.870E-22 7 11
22 18850735 Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Pubmed 6.324E-25 1.633E-23 1.130E-22 3.592E-22 8 31
23 16260596 Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties. Pubmed 1.213E-24 2.995E-23 2.072E-22 6.887E-22 7 12
24 23658844 The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. Pubmed 2.426E-24 5.740E-23 3.972E-22 1.378E-21 8 36
25 22767593 Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. Pubmed 2.627E-24 5.969E-23 4.131E-22 1.492E-21 7 13
26 16036220 CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Pubmed 1.751E-23 3.826E-22 2.647E-21 9.947E-21 7 16
27 24421388 Dynamic regulation of the COP9 signalosome in response to DNA damage. Pubmed 1.364E-22 2.870E-21 1.986E-20 7.750E-20 6 7
28 29103612 Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Pubmed 2.708E-22 5.494E-21 3.802E-20 1.538E-19 8 62
29 24973710 Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes. Pubmed 5.457E-22 1.033E-20 7.150E-20 3.100E-19 6 8
30 10903862 Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. Pubmed 5.457E-22 1.033E-20 7.150E-20 3.100E-19 6 8
31 17079684 DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Pubmed 1.811E-21 3.319E-20 2.297E-19 1.029E-18 7 28
32 22956996 The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. Pubmed 4.092E-21 7.264E-20 5.027E-19 2.325E-18 6 10
33 16503656 Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. Pubmed 5.149E-21 8.601E-20 5.952E-19 2.924E-18 7 32
34 27158335 DCAF4L2 promotes colorectal cancer invasion and metastasis via mediating degradation of NFκb negative regulator PPM1B. Pubmed 5.149E-21 8.601E-20 5.952E-19 2.924E-18 7 32
35 16949367 A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Pubmed 1.574E-20 2.555E-19 1.768E-18 8.943E-18 7 37
36 16045761 Consequences of COP9 signalosome and 26S proteasome interaction. Pubmed 1.560E-19 2.461E-18 1.703E-17 8.861E-17 6 16
37 23086934 The organization of a CSN5-containing subcomplex of the COP9 signalosome. Pubmed 1.861E-19 2.857E-18 1.977E-17 1.057E-16 5 5
38 11114242 The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. Pubmed 1.117E-18 1.669E-17 1.155E-16 6.342E-16 5 6
39 27325702 Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Pubmed 3.030E-18 4.413E-17 3.054E-16 1.721E-15 7 75
40 26456823 CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. Pubmed 3.907E-18 5.549E-17 3.840E-16 2.219E-15 5 7
41 28581483 Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Pubmed 9.599E-18 1.330E-16 9.203E-16 5.452E-15 9 495
42 16624822 Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. Pubmed 1.042E-17 1.409E-16 9.751E-16 5.918E-15 5 8
43 16861906 L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. Pubmed 2.393E-16 3.162E-15 2.188E-14 1.359E-13 5 13
44 17403899 CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Pubmed 3.782E-15 4.882E-14 3.378E-13 2.148E-12 5 21
45 19656241 Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome. Pubmed 4.687E-13 5.916E-12 4.094E-11 2.662E-10 4 11
46 27113764 The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Pubmed 6.758E-13 8.345E-12 5.775E-11 3.839E-10 7 422
47 22190034 Global landscape of HIV-human protein complexes. Pubmed 1.183E-12 1.430E-11 9.894E-11 6.720E-10 7 457
48 10585392 COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. Pubmed 3.618E-11 4.030E-10 2.789E-9 2.055E-8 3 4
49 10991940 Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. Pubmed 3.618E-11 4.030E-10 2.789E-9 2.055E-8 3 4
50 25144743 Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. Pubmed 3.618E-11 4.030E-10 2.789E-9 2.055E-8 3 4
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 1151 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DCAF11 DCAF11 interactions 6.478E-24 7.456E-21 5.686E-20 7.456E-21 9 51
2 int:PHIP PHIP interactions 1.916E-23 1.102E-20 8.407E-20 2.205E-20 9 57
3 int:DCAF4 DCAF4 interactions 1.170E-22 3.188E-20 2.431E-19 1.347E-19 8 28
4 int:LRR1 LRR1 interactions 1.170E-22 3.188E-20 2.431E-19 1.347E-19 8 28
5 int:COPS8 COPS8 interactions 1.385E-22 3.188E-20 2.431E-19 1.594E-19 9 70
6 int:COPS7B COPS7B interactions 1.812E-22 3.477E-20 2.651E-19 2.086E-19 9 72
7 int:GPS1 GPS1 interactions 2.674E-22 4.397E-20 3.353E-19 3.078E-19 9 75
8 int:COPS7A COPS7A interactions 3.043E-21 4.378E-19 3.339E-18 3.502E-18 9 97
9 int:COPS3 COPS3 interactions 4.447E-21 5.687E-19 4.337E-18 5.118E-18 9 101
10 int:COPS4 COPS4 interactions 2.802E-20 3.196E-18 2.437E-17 3.225E-17 9 123
11 int:FBXW4 FBXW4 interactions 3.332E-20 3.196E-18 2.437E-17 3.835E-17 8 53
12 int:FEM1B FEM1B interactions 3.332E-20 3.196E-18 2.437E-17 3.835E-17 8 53
13 int:BTBD1 BTBD1 interactions 3.911E-20 3.463E-18 2.641E-17 4.502E-17 8 54
14 int:COPS2 COPS2 interactions 4.688E-20 3.854E-18 2.939E-17 5.396E-17 9 130
15 int:APBB3 APBB3 interactions 2.189E-19 1.680E-17 1.281E-16 2.519E-16 7 26
16 int:DET1 DET1 interactions 8.745E-19 6.291E-17 4.798E-16 1.007E-15 7 31
17 int:DDA1 DDA1 interactions 1.480E-18 1.002E-16 7.644E-16 1.704E-15 8 83
18 int:KLHL10 KLHL10 interactions 1.789E-18 1.084E-16 8.263E-16 2.059E-15 7 34
19 int:DCAF4L2 DCAF4L2 interactions 1.789E-18 1.084E-16 8.263E-16 2.059E-15 7 34
20 int:DDB2 DDB2 interactions 3.492E-18 2.010E-16 1.533E-15 4.020E-15 8 92
21 int:COP1 COP1 interactions 4.560E-18 2.499E-16 1.906E-15 5.248E-15 8 95
22 int:BTBD2 BTBD2 interactions 1.273E-17 6.415E-16 4.892E-15 1.465E-14 7 44
23 int:DCUN1D1 DCUN1D1 interactions 1.282E-17 6.415E-16 4.892E-15 1.475E-14 9 239
24 int:DCAF1 DCAF1 interactions 1.782E-17 8.547E-16 6.518E-15 2.051E-14 8 112
25 int:NEDD8 NEDD8 interactions 4.045E-17 1.862E-15 1.420E-14 4.655E-14 9 271
26 int:COPS9 COPS9 interactions 5.325E-17 2.358E-15 1.798E-14 6.130E-14 6 19
27 int:ERCC8 ERCC8 interactions 7.694E-17 3.280E-15 2.501E-14 8.856E-14 7 56
28 int:DDB1 DDB1 interactions 8.777E-17 3.608E-15 2.751E-14 1.010E-13 9 295
29 int:CUL4A CUL4A interactions 1.155E-16 4.582E-15 3.494E-14 1.329E-13 9 304
30 int:COPS6 COPS6 interactions 2.007E-16 7.698E-15 5.871E-14 2.310E-13 9 323
31 int:CRBN CRBN interactions 2.192E-16 8.138E-15 6.206E-14 2.523E-13 8 152
32 int:DTL DTL interactions 2.581E-16 9.208E-15 7.022E-14 2.971E-13 7 66
33 int:FBXO17 FBXO17 interactions 2.640E-16 9.208E-15 7.022E-14 3.039E-13 6 24
34 int:CUL5 CUL5 interactions 4.180E-15 1.415E-13 1.079E-12 4.811E-12 9 451
35 int:CUL2 CUL2 interactions 5.517E-15 1.814E-13 1.384E-12 6.350E-12 9 465
36 int:CUL4B CUL4B interactions 8.238E-15 2.634E-13 2.009E-12 9.482E-12 9 486
37 int:DENR DENR interactions 3.518E-14 1.095E-12 8.347E-12 4.050E-11 6 51
38 int:DCAF8 DCAF8 interactions 1.610E-13 4.878E-12 3.720E-11 1.854E-10 6 65
39 int:FBXL14 FBXL14 interactions 1.029E-12 3.036E-11 2.315E-10 1.184E-9 5 29
40 int:KLHL13 KLHL13 interactions 1.471E-12 4.233E-11 3.228E-10 1.693E-9 5 31
41 int:LRRC14 LRRC14 interactions 1.015E-11 2.849E-10 2.172E-9 1.168E-8 4 11
42 int:EPB41L1 EPB41L1 interactions 7.687E-11 2.107E-9 1.606E-8 8.848E-8 5 66
43 int:RBX1 RBX1 interactions 8.049E-11 2.155E-9 1.643E-8 9.265E-8 6 179
44 int:WDTC1 WDTC1 interactions 2.221E-10 5.739E-9 4.377E-8 2.557E-7 7 449
45 int:KLHL18 KLHL18 interactions 2.244E-10 5.739E-9 4.377E-8 2.583E-7 4 22
46 int:IRF8 IRF8 interactions 5.377E-10 1.345E-8 1.026E-7 6.189E-7 4 27
47 int:APPBP2 APPBP2 interactions 1.623E-9 3.974E-8 3.030E-7 1.868E-6 5 120
48 int:ELOB ELOB interactions 1.915E-9 4.593E-8 3.503E-7 2.205E-6 5 124
49 int:EIF3E EIF3E interactions 2.249E-9 5.283E-8 4.029E-7 2.589E-6 5 128
50 int:FBXL5 FBXL5 interactions 2.513E-9 5.786E-8 4.412E-7 2.893E-6 4 39
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q21.22 4q21.22 4.665E-3 2.252E-2
6.370E-2
 4.198E-2 1 18
2 8q13.1 8q13.1 6.215E-3 2.252E-2
6.370E-2
5.594E-2
 1 24
3 15q21.2 15q21.2 7.506E-3 2.252E-2
6.370E-2
6.755E-2
 1 29
4 14q12 14q12 1.445E-2 2.876E-2
8.136E-2
1.300E-1
 1 56
5 2q37.1 2q37.1 1.752E-2 2.876E-2
8.136E-2
1.577E-1
 1 68
6 12p13.31 12p13.31 2.135E-2 2.876E-2
8.136E-2
1.921E-1
 1 83
7 2q37.3 2q37.3 2.237E-2 2.876E-2
8.136E-2
2.013E-1
 1 87
8 7q22.1 7q22.1 2.972E-2 3.344E-2
9.460E-2
2.675E-1
 1 116
9 17p11.2 17p11.2 4.354E-2 4.354E-2
1.232E-1
3.919E-1
 1 171
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 27 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 932 COP9 signalosome genenames.org 3.027E-29 3.027E-29 3.027E-29 3.027E-29 8 9

13: Coexpression [Display Chart] 9 input genes in category / 653 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2982 Genes down-regulated in B lymphocytes stimulated by anti-IgM: 2h versus 12h. MSigDB C7: Immunologic Signatures (v6.0) 3.821E-5 6.473E-3 4.569E-2 2.495E-2 3 181
2 M5102 Genes up-regulated in comparison of untreated CD8+ dendritic cells (DC) at 4 h versus those treated with IFNG [GeneID=3458] at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 6.473E-3 4.569E-2 3.309E-2 3 199
3 M6124 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL4 [GeneID=3565] (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 6.473E-3 4.569E-2 3.359E-2 3 200
4 M9457 Genes down-regulated in CD8 T effector cells, acute infection with LCMV-Armstrong: day 6 versus day 8. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 6.473E-3 4.569E-2 3.359E-2 3 200
5 M9695 Genes up-regulated in DLBCL (diffuse large B-cell lymphoma) cell lines sensitive to stimulation of CD40 [GeneID=958] relative to the resistant ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.221E-5 6.473E-3 4.569E-2 3.409E-2 3 201
6 15284076-TableE2 Human Lung not cancer Golpon04 242genes GeneSigDB 5.947E-5 6.473E-3 4.569E-2 3.884E-2 3 210
7 14871973-Table2 Human Breast Kote-Jarai04 79genes GeneSigDB 2.198E-4 2.051E-2
1.448E-1
1.436E-1
 2 58
8 M29 Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.728E-4 3.533E-2
2.494E-1
3.088E-1
 3 424
9 M12591 Genes up-regulated by 3 h of euglycemic hyperinsulinemic clamp in the vastus lateralis muscle of healthy lean subjects. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.339E-4 3.533E-2
2.494E-1
3.486E-1
 3 442
10 15284076-Figure1 Human Lung not cancer Golpon04 150genes GeneSigDB 9.378E-4 3.533E-2
2.494E-1
6.124E-1
 2 120
11 15284076-TableE1 Human Lung not cancer Golpon04 150genes NMLvsADLvsEML GeneSigDB 1.202E-3 3.533E-2
2.494E-1
7.848E-1
 2 136
12 M6110 Genes down-regulated in patients at the incipient stage of Alzheimer's disease. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.761E-3 3.533E-2
2.494E-1
1.000E0
 2 165
13 M6825 Genes up-regulated in monocytes: untreated versus anti- FcgRIIB. MSigDB C7: Immunologic Signatures (v6.0) 1.782E-3 3.533E-2
2.494E-1
1.000E0
 2 166
14 M7003 Genes down-regulated in B lymphocytes: wildtype versus ZFX [GeneID=7543]. MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 3.533E-2
2.494E-1
1.000E0
 2 173
15 M2939 Genes down-regulated in CD8 T cells: undergoing deletional tolerance versus activated. MSigDB C7: Immunologic Signatures (v6.0) 1.978E-3 3.533E-2
2.494E-1
1.000E0
 2 175
16 M2336 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.113E-3 3.533E-2
2.494E-1
1.000E0
 2 181
17 M2955 Genes up-regulated in T reg: induced versus failed induced. MSigDB C7: Immunologic Signatures (v6.0) 2.183E-3 3.533E-2
2.494E-1
1.000E0
 2 184
18 M2295 Genes down-regulated in I/11 erythroblast cells upon expression of an activated form of FOXO3 [GeneID=2309]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.253E-3 3.533E-2
2.494E-1
1.000E0
 2 187
19 M4973 Genes down-regulated in comparison of B cells from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 3.533E-2
2.494E-1
1.000E0
 2 197
20 M5490 Up-regulated by induction of exogenous BRCA1 in EcR-293 cells MSigDB C2: CGP Curated Gene Sets (v6.0) 2.521E-3 3.533E-2
2.494E-1
1.000E0
 2 198
21 M3299 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 21 days after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.533E-2
2.494E-1
1.000E0
 2 198
22 M5170 Genes up-regulated in comparison of macrophages versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.533E-2
2.494E-1
1.000E0
 2 199
23 M5222 Genes up-regulated in comparison of dendritic cells (DC) exposed to 50 worms/well B. malayi versus those exposed to 5 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.533E-2
2.494E-1
1.000E0
 2 199
24 M9603 Genes down-regulated in T conv: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.533E-2
2.494E-1
1.000E0
 2 199
25 M5419 Genes down-regulated in comparison of eosinophils versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.533E-2
2.494E-1
1.000E0
 2 199
26 M6442 Genes down-regulated in CD8A [GeneID=925] T cells versus B1 B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
27 M3600 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with IL12. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
28 M4898 Genes up-regulated in comparison of primary splenic B cells from wild type mice versus those from BTK [GeneID=695] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
29 M5999 Genes up-regulated in macrophages: untreated versus IL6 [GeneID=3569] for 400min. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
30 M3479 Genes down-regulated in comparison of CD4 [GeneID=920] thymocytes versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
31 M4454 Genes down-regulated in comparison of memory IgM B cells versus blood plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
32 M3713 Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with poly(I:C) (TLR3 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
33 M7135 Genes up-regulated in wildtype splenic dendritic cells: CD8A+ [GeneID=925] versus CD8A- [GeneID=925]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
34 M6365 Genes down-regulated in dendiritic cells from speen: interferon producing killer cells versus plasmacytoid. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
35 M4754 Genes up-regulated in comparison of LSK versus NKT cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
36 M3628 Genes down-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after treatment with trichostatin A (TSA) [PubChem=5562]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
37 M9120 Genes down-regulated in CD4 T conv: control versus over-expression of IKZF2 and FOXP3 [GeneID=22807;50943]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
38 M9773 Genes down-regulated in MME+ [GeneID=4311] germinal center B lymphocytes: control versus over-expressing viral (EBV) gene LMP2A. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
39 M3623 Genes up-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
40 M4186 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
41 M8638 Genes up-regulated in bone marrow-derived dendritic cells: unstimulated versus low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
42 M7365 Genes up-regulated in the activated CD4 [GeneID=920] T cells (48h): control versus IL-12. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
43 M3666 Genes up-regulated in comparison of stimulated naive CD8 T cells from pmel-1 mice versus unstimulated naive CD8 T cells from pmel-1 mice. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
44 M7376 Genes down-regulated in the activated CD4 [GeneID=920] T cells (48h): control versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
45 M9767 Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Th1 versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
46 M9123 Genes up-regulated in T reg: XBP1 [GeneID=7494] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
47 M6361 Genes up-regulated in gamma delta T cells: Vd1 versus Vd2. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.533E-2
2.494E-1
1.000E0
 2 200
48 16513838-TableS1 Human HeadandNeck Cloos06 52genes GeneListBleoComparison GeneSigDB 2.597E-3 3.533E-2
2.494E-1
1.000E0
 2 201
49 M9473 Genes enriched in embryonic, neural and hematopoietic stem cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.725E-3 3.632E-2
2.564E-1
1.000E0
 2 206
Show 44 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 223 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor Top 200 Genes 2.960E-4 3.286E-2
1.967E-1
6.601E-2
 3 341
2 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor E16.5 Top 200 Genes 2.960E-4 3.286E-2
1.967E-1
6.601E-2
 3 341
3 Facebase RNAseq e10.5 Maxillary Arch 2500 K2 FacebaseRNAseq e10.5 Maxillary Arch top-relative-expression-ranked 2500 k-means-cluster#2 FaceBase_RNAseq 4.421E-4 3.286E-2
1.967E-1
9.859E-2
 3 391

15: Computational [Display Chart] 9 input genes in category / 97 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2967 MORF AP2M1 Neighborhood of AP2M1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.604E-4 3.018E-2
1.557E-1
7.376E-2
 3 217
2 M5380 MORF BAG5 Neighborhood of BAG5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.112E-3 3.018E-2
1.557E-1
1.079E-1
 2 57
3 M1715 MORF XPC Neighborhood of XPC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.314E-3 3.018E-2
1.557E-1
1.275E-1
 2 62
4 M17615 MORF RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.403E-3 3.018E-2
1.557E-1
1.361E-1
 3 268
5 M5741 GCM HBP1 Neighborhood of HBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.625E-3 3.018E-2
1.557E-1
1.577E-1
 2 69
6 M5260 MODULE 72 Testis genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.154E-3 3.018E-2
1.557E-1
2.089E-1
 3 311
7 M12803 MORF ATOX1 Neighborhood of ATOX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.178E-3 3.018E-2
1.557E-1
2.113E-1
 2 80
8 M10404 MORF MBD4 Neighborhood of MBD4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.512E-3 3.046E-2
1.571E-1
2.437E-1
 2 86
9 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.455E-3 3.716E-2
1.917E-1
3.352E-1
 3 367
10 M9199 MODULE 3 Genes in the cancer module 3. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.958E-3 3.716E-2
1.917E-1
3.839E-1
 3 385
11 M16184 MORF ERH Neighborhood of ERH MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.370E-3 3.716E-2
1.917E-1
4.239E-1
 2 114
12 M11641 MORF PSMC2 Neighborhood of PSMC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.598E-3 3.716E-2
1.917E-1
4.460E-1
 2 117
13 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.094E-3 3.801E-2
1.960E-1
4.941E-1
 3 421
14 M15619 MODULE 18 Genes in the cancer module 18. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.180E-3 4.282E-2
2.208E-1
5.995E-1
 3 451
15 M18071 MORF PRKAR1A Neighborhood of PRKAR1A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.704E-3 4.335E-2
2.236E-1
6.503E-1
 2 142
16 M19908 MORF NME2 Neighborhood of NME2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.845E-3 4.756E-2
2.453E-1
7.610E-1
 2 154
Show 11 more annotations

16: MicroRNA [Display Chart] 9 input genes in category / 264 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-let-7e-3p:Functional MTI Functional MTI miRTarbase 7.584E-7 2.002E-4 1.232E-3 2.002E-4 2 11
2 hsa-miR-1273:mirSVR lowEffct hsa-miR-1273:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.421E-5 3.196E-3 1.967E-2 6.393E-3 3 483
3 hsa-miR-1185:PITA hsa-miR-1185:PITA TOP PITA 7.341E-5 5.812E-3 3.577E-2 1.938E-2 2 104
4 hsa-miR-328-3p:Functional MTI Functional MTI miRTarbase 1.183E-4 5.812E-3 3.577E-2 3.123E-2 2 132
5 hsa-miR-1322:PITA hsa-miR-1322:PITA TOP PITA 1.237E-4 5.812E-3 3.577E-2 3.266E-2 2 135
6 GCATTTG,MIR-105:MSigDB GCATTTG,MIR-105:MSigDB MSigDB 1.803E-4 5.812E-3 3.577E-2 4.759E-2 2 163
7 hsa-miR-7-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.984E-4 5.812E-3 3.577E-2
5.237E-2
 2 171
8 hsa-miR-7-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.296E-4 5.812E-3 3.577E-2
6.060E-2
 2 184
9 hsa-miR-1197:PITA hsa-miR-1197:PITA TOP PITA 2.396E-4 5.812E-3 3.577E-2
6.326E-2
 2 188
10 hsa-miR-330-5p:PITA hsa-miR-330-5p:PITA TOP PITA 2.422E-4 5.812E-3 3.577E-2
6.393E-2
 2 189
11 hsa-miR-326:PITA hsa-miR-326:PITA TOP PITA 2.422E-4 5.812E-3 3.577E-2
6.393E-2
 2 189
12 hsa-miR-665:PITA hsa-miR-665:PITA TOP PITA 3.044E-4 6.697E-3 4.122E-2
8.037E-2
 2 212
13 hsa-miR-1205:PITA hsa-miR-1205:PITA TOP PITA 3.457E-4 7.021E-3 4.322E-2
9.127E-2
 2 226
14 hsa-miR-223-3p:TargetScan hsa-miR-223-3p TargetScan 5.368E-4 9.622E-3
5.922E-2
1.417E-1
 2 282
15 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 5.831E-4 9.622E-3
5.922E-2
1.539E-1
 2 294
16 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 5.831E-4 9.622E-3
5.922E-2
1.539E-1
 2 294
17 hsa-miR-338-3p:TargetScan hsa-miR-338-3p TargetScan 7.465E-4 1.101E-2
6.779E-2
1.971E-1
 2 333
18 hsa-let-7i-5p:Functional MTI Functional MTI miRTarbase 7.510E-4 1.101E-2
6.779E-2
1.983E-1
 2 334
19 hsa-miR-665:TargetScan hsa-miR-665 TargetScan 8.521E-4 1.139E-2
7.013E-2
2.250E-1
 2 356
20 hsa-miR-330-5p:TargetScan hsa-miR-330-5p TargetScan 9.148E-4 1.139E-2
7.013E-2
2.415E-1
 2 369
21 hsa-miR-326:TargetScan hsa-miR-326 TargetScan 9.148E-4 1.139E-2
7.013E-2
2.415E-1
 2 369
22 hsa-miR-504:mirSVR highEffct hsa-miR-504:mirSVR conserved highEffect-0.5 MicroRNA.org 9.494E-4 1.139E-2
7.013E-2
2.506E-1
 2 376
23 hsa-let-7f-5p:Functional MTI Functional MTI miRTarbase 1.057E-3 1.213E-2
7.469E-2
2.791E-1
 2 397
24 hsa-miR-1234:mirSVR lowEffct hsa-miR-1234:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.198E-3 1.227E-2
7.552E-2
3.164E-1
 2 423
25 hsa-miR-2114*:mirSVR highEffct hsa-miR-2114*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.232E-3 1.227E-2
7.552E-2
3.253E-1
 2 429
26 hsa-miR-27a*:mirSVR highEffct hsa-miR-27a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.243E-3 1.227E-2
7.552E-2
3.283E-1
 2 431
27 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 1.255E-3 1.227E-2
7.552E-2
3.313E-1
 2 433
28 hsa-miR-1277:mirSVR lowEffct hsa-miR-1277:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.402E-3 1.322E-2
8.136E-2
3.701E-1
 2 458
29 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.481E-3 1.349E-2
8.301E-2
3.911E-1
 2 471
30 hsa-miR-541:mirSVR highEffct hsa-miR-541:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.550E-3 1.364E-2
8.398E-2
4.093E-1
 2 482
31 hsa-miR-8053:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-3 1.590E-2
9.788E-2
4.930E-1
 1 15
32 hsa-miR-4462:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.489E-3 2.053E-2
1.264E-1
6.571E-1
 1 20
33 hsa-miR-4796-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.359E-3 2.687E-2
1.654E-1
8.868E-1
 1 27
34 hsa-miR-6763-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.483E-3 2.705E-2
1.665E-1
9.195E-1
 1 28
35 hsa-miR-6851-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 3.593E-2
2.212E-1
1.000E0
 1 40
36 hsa-miR-4707-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.097E-3 3.593E-2
2.212E-1
1.000E0
 1 41
37 hsa-miR-5587-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.593E-2
2.212E-1
1.000E0
 1 42
38 hsa-miR-133a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.345E-3 3.593E-2
2.212E-1
1.000E0
 1 43
39 hsa-miR-6724-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.593E-2
2.212E-1
1.000E0
 1 46
40 hsa-miR-6773-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.593E-2
2.212E-1
1.000E0
 1 46
41 hsa-miR-4474-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.593E-2
2.212E-1
1.000E0
 1 46
42 hsa-miR-342-5p:PITA hsa-miR-342-5p:PITA TOP PITA 5.717E-3 3.593E-2
2.212E-1
1.000E0
 1 46
43 hsa-miR-136-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.964E-3 3.662E-2
2.254E-1
1.000E0
 1 48
44 hsa-miR-556-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.708E-3 3.976E-2
2.448E-1
1.000E0
 1 54
45 GTACAGG,MIR-486:MSigDB GTACAGG,MIR-486:MSigDB MSigDB 6.832E-3 3.976E-2
2.448E-1
1.000E0
 1 55
46 ATAACCT,MIR-154:MSigDB ATAACCT,MIR-154:MSigDB MSigDB 6.955E-3 3.976E-2
2.448E-1
1.000E0
 1 56
47 hsa-miR-718:mirSVR highEffct hsa-miR-718:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.079E-3 3.976E-2
2.448E-1
1.000E0
 1 57
48 hsa-miR-514b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.946E-3 4.261E-2
2.622E-1
1.000E0
 1 64
49 hsa-miR-1288:PITA hsa-miR-1288:PITA TOP PITA 8.069E-3 4.261E-2
2.622E-1
1.000E0
 1 65
50 hsa-miR-514a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.069E-3 4.261E-2
2.622E-1
1.000E0
 1 65
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 767 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006437867 D dB Stitch 3.049E-6 2.339E-3 1.689E-2 2.339E-3 3 77
2 CID000447378 p 5a Stitch 2.105E-5 8.072E-3
5.828E-2
 1.614E-2 2 18
3 CID000001978 acebutolol Stitch 3.175E-5 8.118E-3
5.861E-2
 2.435E-2 2 22
4 CID006420160 2f34 Stitch 4.445E-5 8.523E-3
6.154E-2
 3.409E-2 3 188
5 CID000065096 6-sulfatoxymelatonin Stitch 5.573E-5 8.548E-3
6.172E-2
 4.274E-2 2 29
6 CID000000801 auxin Stitch 7.484E-5 9.567E-3
6.908E-2
5.740E-2
 3 224
7 CID000444966 Cu L Stitch 1.123E-4 1.230E-2
8.882E-2
8.611E-2
 2 41
8 CID005318463 iridal Stitch 1.542E-4 1.479E-2
1.068E-1
1.183E-1
 2 48
9 CID000024014 CuCl2 Stitch 1.954E-4 1.665E-2
1.202E-1
1.499E-1
 2 54
10 CID000085040 CPDS Stitch 3.102E-4 2.379E-2
1.718E-1
2.379E-1
 2 68
11 CID000009981 neoarsphenamine Stitch 3.940E-4 2.747E-2
1.984E-1
3.022E-1
 1 1
12 CID000004111 AC1L1HFP Stitch 6.046E-4 3.865E-2
2.790E-1
4.637E-1
 2 95
13 CID000149966 Sr26 Stitch 7.879E-4 4.649E-2
3.357E-1
6.043E-1
 1 2
Show 8 more annotations

18: Disease [Display Chart] 9 input genes in category / 28 annotations before applied cutoff / 16205 genes in category

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