Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc83_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 40 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003924 GTPase activity 1.625E-22 6.500E-21 2.781E-20 6.500E-21 12 236
2 GO:0005525 GTP binding 5.124E-20 1.019E-18 4.360E-18 2.050E-18 12 378
3 GO:0032561 guanyl ribonucleotide binding 9.885E-20 1.019E-18 4.360E-18 3.954E-18 12 399
4 GO:0019001 guanyl nucleotide binding 1.019E-19 1.019E-18 4.360E-18 4.076E-18 12 400
5 GO:0019003 GDP binding 6.307E-8 5.046E-7 2.159E-6 2.523E-6 4 59
6 GO:0005086 ARF guanyl-nucleotide exchange factor activity 1.226E-4 8.172E-4 3.497E-3 4.903E-3 2 24
7 GO:1990583 phospholipase D activator activity 6.966E-4 3.981E-3 1.703E-2 2.787E-2 1 1
8 GO:0016004 phospholipase activator activity 8.330E-3 3.413E-2
1.460E-1
3.332E-1
 1 12
9 GO:0031996 thioesterase binding 9.712E-3 3.413E-2
1.460E-1
3.885E-1
 1 14
10 GO:0005095 GTPase inhibitor activity 9.712E-3 3.413E-2
1.460E-1
3.885E-1
 1 14
11 GO:0060229 lipase activator activity 9.712E-3 3.413E-2
1.460E-1
3.885E-1
 1 14
12 GO:0050811 GABA receptor binding 1.040E-2 3.413E-2
1.460E-1
4.161E-1
 1 15
13 GO:0034237 protein kinase A regulatory subunit binding 1.109E-2 3.413E-2
1.460E-1
4.437E-1
 1 16
Show 8 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 297 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0048193 Golgi vesicle transport 1.352E-11 4.015E-9 2.519E-8 4.015E-9 8 340
2 GO:0006892 post-Golgi vesicle-mediated transport 4.386E-7 6.513E-5 4.085E-4 1.303E-4 4 95
3 GO:0031584 activation of phospholipase D activity 9.428E-6 9.334E-4 5.855E-3 2.800E-3 2 7
4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 2.038E-5 1.513E-3 9.492E-3 6.053E-3 3 79
5 GO:0060996 dendritic spine development 2.723E-5 1.617E-3 1.015E-2 8.087E-3 3 87
6 GO:0032273 positive regulation of protein polymerization 6.271E-5 3.104E-3 1.947E-2 1.863E-2 3 115
7 GO:0006471 protein ADP-ribosylation 1.448E-4 6.144E-3 3.854E-2 4.301E-2 2 26
8 GO:0032271 regulation of protein polymerization 2.483E-4 8.223E-3
5.158E-2
7.374E-2
 3 183
9 GO:0034067 protein localization to Golgi apparatus 2.492E-4 8.223E-3
5.158E-2
7.401E-2
 2 34
10 GO:0051495 positive regulation of cytoskeleton organization 2.993E-4 8.888E-3
5.575E-2
8.888E-2
 3 195
11 GO:0031334 positive regulation of protein complex assembly 4.731E-4 1.209E-2
7.581E-2
1.405E-1
 3 228
12 GO:0006893 Golgi to plasma membrane transport 5.407E-4 1.209E-2
7.581E-2
1.606E-1
 2 50
13 GO:0016358 dendrite development 5.428E-4 1.209E-2
7.581E-2
1.612E-1
 3 239
14 GO:0051258 protein polymerization 5.697E-4 1.209E-2
7.581E-2
1.692E-1
 3 243
15 GO:0010518 positive regulation of phospholipase activity 6.542E-4 1.220E-2
7.650E-2
1.943E-1
 2 55
16 GO:0016197 endosomal transport 6.859E-4 1.220E-2
7.650E-2
2.037E-1
 3 259
17 GO:0070142 synaptic vesicle budding 6.981E-4 1.220E-2
7.650E-2
2.073E-1
 1 1
18 GO:0060998 regulation of dendritic spine development 9.127E-4 1.412E-2
8.857E-2
2.711E-1
 2 65
19 GO:0007034 vacuolar transport 9.331E-4 1.412E-2
8.857E-2
2.771E-1
 3 288
20 GO:0010517 regulation of phospholipase activity 9.694E-4 1.412E-2
8.857E-2
2.879E-1
 2 67
21 GO:0060193 positive regulation of lipase activity 9.984E-4 1.412E-2
8.857E-2
2.965E-1
 2 68
22 GO:0042147 retrograde transport, endosome to Golgi 1.181E-3 1.594E-2
1.000E-1
3.508E-1
 2 74
23 GO:1902824 positive regulation of late endosome to lysosome transport 1.396E-3 1.727E-2
1.083E-1
4.145E-1
 1 2
24 GO:0055108 Golgi to transport vesicle transport 1.396E-3 1.727E-2
1.083E-1
4.145E-1
 1 2
25 GO:0048259 regulation of receptor-mediated endocytosis 1.554E-3 1.846E-2
1.158E-1
4.616E-1
 2 85
26 GO:0060191 regulation of lipase activity 1.627E-3 1.859E-2
1.166E-1
4.833E-1
 2 87
27 GO:0030838 positive regulation of actin filament polymerization 1.896E-3 2.086E-2
1.308E-1
5.632E-1
 2 94
28 GO:0097212 lysosomal membrane organization 2.093E-3 2.220E-2
1.392E-1
6.216E-1
 1 3
29 GO:0043254 regulation of protein complex assembly 2.396E-3 2.454E-2
1.539E-1
7.117E-1
 3 400
30 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport 2.790E-3 2.673E-2
1.676E-1
8.285E-1
 1 4
31 GO:1902822 regulation of late endosome to lysosome transport 2.790E-3 2.673E-2
1.676E-1
8.285E-1
 1 4
32 GO:0051493 regulation of cytoskeleton organization 3.388E-3 2.993E-2
1.877E-1
1.000E0
 3 452
33 GO:0044089 positive regulation of cellular component biogenesis 3.410E-3 2.993E-2
1.877E-1
1.000E0
 3 453
34 GO:0006661 phosphatidylinositol biosynthetic process 3.426E-3 2.993E-2
1.877E-1
1.000E0
 2 127
35 GO:1902774 late endosome to lysosome transport 4.182E-3 3.548E-2
2.226E-1
1.000E0
 1 6
36 GO:0030833 regulation of actin filament polymerization 4.620E-3 3.807E-2
2.388E-1
1.000E0
 2 148
37 GO:0050773 regulation of dendrite development 4.742E-3 3.807E-2
2.388E-1
1.000E0
 2 150
38 GO:0030041 actin filament polymerization 5.641E-3 4.332E-2
2.717E-1
1.000E0
 2 164
39 GO:0043112 receptor metabolic process 5.708E-3 4.332E-2
2.717E-1
1.000E0
 2 165
40 GO:0008064 regulation of actin polymerization or depolymerization 5.911E-3 4.332E-2
2.717E-1
1.000E0
 2 168
41 GO:0030832 regulation of actin filament length 5.980E-3 4.332E-2
2.717E-1
1.000E0
 2 169
42 GO:0015870 acetylcholine transport 6.266E-3 4.398E-2
2.759E-1
1.000E0
 1 9
43 GO:0006888 ER to Golgi vesicle-mediated transport 6.612E-3 4.398E-2
2.759E-1
1.000E0
 2 178
44 GO:0007163 establishment or maintenance of cell polarity 6.829E-3 4.398E-2
2.759E-1
1.000E0
 2 181
45 GO:1901374 acetate ester transport 6.960E-3 4.398E-2
2.759E-1
1.000E0
 1 10
46 GO:0034379 very-low-density lipoprotein particle assembly 6.960E-3 4.398E-2
2.759E-1
1.000E0
 1 10
47 GO:0007021 tubulin complex assembly 6.960E-3 4.398E-2
2.759E-1
1.000E0
 1 10
48 GO:0008154 actin polymerization or depolymerization 7.654E-3 4.736E-2
2.971E-1
1.000E0
 2 192
49 GO:0046578 regulation of Ras protein signal transduction 8.281E-3 4.826E-2
3.027E-1
1.000E0
 2 200
50 GO:0046488 phosphatidylinositol metabolic process 8.441E-3 4.826E-2
3.027E-1
1.000E0
 2 202
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 70 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005802 trans-Golgi network 1.058E-5 7.409E-4 3.581E-3 7.409E-4 4 216
2 GO:0098791 Golgi subcompartment 5.317E-5 1.478E-3 7.142E-3 3.722E-3 4 326
3 GO:0031984 organelle subcompartment 6.334E-5 1.478E-3 7.142E-3 4.433E-3 4 341
4 GO:0032588 trans-Golgi network membrane 1.383E-3 2.420E-2
1.169E-1
9.680E-2
 2 82
5 GO:0031252 cell leading edge 2.072E-3 2.725E-2
1.317E-1
1.450E-1
 3 389
6 GO:0032280 symmetric synapse 2.726E-3 2.725E-2
1.317E-1
1.908E-1
 1 4
7 GO:0005879 axonemal microtubule 2.726E-3 2.725E-2
1.317E-1
1.908E-1
 1 4
8 GO:0098794 postsynapse 3.114E-3 2.725E-2
1.317E-1
2.180E-1
 3 449
9 GO:0030496 midbody 3.798E-3 2.748E-2
1.328E-1
2.658E-1
 2 137
10 GO:0055037 recycling endosome 3.962E-3 2.748E-2
1.328E-1
2.773E-1
 2 140
11 GO:0043197 dendritic spine 4.592E-3 2.748E-2
1.328E-1
3.214E-1
 2 151
12 GO:0044309 neuron spine 4.711E-3 2.748E-2
1.328E-1
3.298E-1
 2 153
13 GO:0001726 ruffle 5.717E-3 3.078E-2
1.488E-1
4.002E-1
 2 169
Show 8 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 36 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007165 Periventricular gray matter heterotopia 3.187E-3 3.569E-2
1.490E-1
1.147E-1
 1 15
2 HP:0010636 Schizencephaly 3.824E-3 3.569E-2
1.490E-1
1.377E-1
 1 18
3 HP:0010522 Dyslexia 4.461E-3 3.569E-2
1.490E-1
1.606E-1
 1 21
4 HP:0007291 Posterior fossa cyst 5.311E-3 3.569E-2
1.490E-1
1.912E-1
 1 25
5 HP:0002281 Gray matter heterotopias 5.736E-3 3.569E-2
1.490E-1
2.065E-1
 1 27
6 HP:0000817 Poor eye contact 5.949E-3 3.569E-2
1.490E-1
2.141E-1
 1 28
7 HP:0002273 Tetraparesis 1.020E-2 4.461E-2
1.862E-1
3.671E-1
 1 48
8 HP:0000735 Impaired social interactions 1.147E-2 4.461E-2
1.862E-1
4.130E-1
 1 54
9 HP:0000253 Progressive microcephaly 1.253E-2 4.461E-2
1.862E-1
4.512E-1
 1 59
10 HP:0012433 Abnormal social behavior 1.317E-2 4.461E-2
1.862E-1
4.742E-1
 1 62
11 HP:0002521 Hypsarrhythmia 1.445E-2 4.461E-2
1.862E-1
5.201E-1
 1 68
12 HP:0001339 Lissencephaly 1.487E-2 4.461E-2
1.862E-1
5.354E-1
 1 70
13 HP:0030182 Tetraplegia/tetraparesis 1.615E-2 4.471E-2
1.867E-1
5.813E-1
 1 76
14 HP:0002282 Heterotopia 1.763E-2 4.487E-2
1.873E-1
6.348E-1
 1 83
15 HP:0011198 EEG with generalized epileptiform discharges 1.870E-2 4.487E-2
1.873E-1
6.730E-1
 1 88
16 HP:0011182 Interictal epileptiform activity 1.997E-2 4.493E-2
1.876E-1
7.189E-1
 1 94
Show 11 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 101 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 13 input genes in category / 37 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS51417 ARF PROSITE 1.733E-34 3.206E-33 1.347E-32 6.411E-33 12 29
2 IPR024156 Small GTPase ARF InterPro 1.733E-34 3.206E-33 1.347E-32 6.411E-33 12 29
3 PF00025 Arf Pfam 4.711E-34 5.811E-33 2.441E-32 1.743E-32 12 31
4 IPR006689 Small GTPase ARF/SAR InterPro 1.184E-33 1.096E-32 4.603E-32 4.383E-32 12 33
5 IPR005225 Small GTP-bd dom InterPro 2.174E-24 1.608E-23 6.758E-23 8.042E-23 12 167
6 IPR001806 Small GTPase InterPro 4.344E-19 2.679E-18 1.126E-17 1.607E-17 10 160
7 PF09324 DUF1981 Pfam 2.773E-3 8.550E-3 3.592E-2
1.026E-1
 1 4
8 IPR032629 DCB dom InterPro 2.773E-3 8.550E-3 3.592E-2
1.026E-1
 1 4
9 PF16213 DCB Pfam 2.773E-3 8.550E-3 3.592E-2
1.026E-1
 1 4
10 IPR032691 Sec7 N InterPro 2.773E-3 8.550E-3 3.592E-2
1.026E-1
 1 4
11 PF12783 Sec7 N Pfam 2.773E-3 8.550E-3 3.592E-2
1.026E-1
 1 4
12 IPR015403 Sec7 C InterPro 2.773E-3 8.550E-3 3.592E-2
1.026E-1
 1 4
13 PF14634 zf-RING 5 Pfam 4.157E-3 1.183E-2 4.971E-2
1.538E-1
 1 6
14 IPR023394 Sec7 alpha orthog InterPro 1.036E-2 1.947E-2
8.179E-2
3.834E-1
 1 15
15 PF01369 Sec7 Pfam 1.036E-2 1.947E-2
8.179E-2
3.834E-1
 1 15
16 SM00502 BBC SMART 1.036E-2 1.947E-2
8.179E-2
3.834E-1
 1 15
17 1.10.1000.11 - Gene3D 1.036E-2 1.947E-2
8.179E-2
3.834E-1
 1 15
18 IPR003649 Bbox C InterPro 1.036E-2 1.947E-2
8.179E-2
3.834E-1
 1 15
19 SM00222 Sec7 SMART 1.105E-2 1.947E-2
8.179E-2
4.088E-1
 1 16
20 PS50190 SEC7 PROSITE 1.105E-2 1.947E-2
8.179E-2
4.088E-1
 1 16
21 IPR000904 Sec7 dom InterPro 1.105E-2 1.947E-2
8.179E-2
4.088E-1
 1 16
22 IPR001019 Gprotein alpha su InterPro 1.174E-2 1.974E-2
8.293E-2
4.342E-1
 1 17
Show 17 more annotations

7: Pathway [Display Chart] 12 input genes in category / 61 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00029 Huntington disease PantherDB 3.453E-14 2.106E-12 9.892E-12 2.106E-12 8 123
2 1383038 Intra-Golgi and retrograde Golgi-to-ER traffic BioSystems: REACTOME 7.225E-9 2.204E-7 1.035E-6 4.407E-7 6 180
3 1339109 COPI-mediated anterograde transport BioSystems: REACTOME 7.151E-7 1.331E-5 6.251E-5 4.362E-5 4 79
4 1383042 COPI-dependent Golgi-to-ER retrograde traffic BioSystems: REACTOME 8.728E-7 1.331E-5 6.251E-5 5.324E-5 4 83
5 102279 Endocytosis BioSystems: KEGG 2.685E-6 2.851E-5 1.339E-4 1.638E-4 5 260
6 1383041 Golgi-to-ER retrograde transport BioSystems: REACTOME 2.804E-6 2.851E-5 1.339E-4 1.710E-4 4 111
7 1268726 ER to Golgi Anterograde Transport BioSystems: REACTOME 5.940E-6 5.177E-5 2.431E-4 3.624E-4 4 134
8 138022 Class I PI3K signaling events BioSystems: Pathway Interaction Database 7.144E-6 5.448E-5 2.558E-4 4.358E-4 3 41
9 1268725 Transport to the Golgi and subsequent modification BioSystems: REACTOME 1.355E-5 9.187E-5 4.314E-4 8.268E-4 4 165
10 M1529 Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. MSigDB C2 BIOCARTA (v6.0) 8.880E-5 4.925E-4 2.313E-3 5.417E-3 2 15
11 138038 Arf6 downstream pathway BioSystems: Pathway Interaction Database 8.880E-5 4.925E-4 2.313E-3 5.417E-3 2 15
12 1268714 Asparagine N-linked glycosylation BioSystems: REACTOME 1.151E-4 5.852E-4 2.748E-3 7.023E-3 4 285
13 M2482 ADP-Ribosylation Factor MSigDB C2 BIOCARTA (v6.0) 1.292E-4 6.062E-4 2.847E-3 7.881E-3 2 18
14 1270075 Synthesis of PIPs at the Golgi membrane BioSystems: REACTOME 1.443E-4 6.288E-4 2.953E-3 8.803E-3 2 19
15 P00034 Integrin signalling pathway PantherDB 4.771E-4 1.940E-3 9.112E-3 2.910E-2 3 167
16 1383039 Retrograde transport at the Trans-Golgi-Network BioSystems: REACTOME 9.767E-4 3.724E-3 1.749E-2
5.958E-2
 2 49
17 1268848 Cargo trafficking to the periciliary membrane BioSystems: REACTOME 1.142E-3 4.098E-3 1.924E-2
6.966E-2
 2 53
18 1270073 PI Metabolism BioSystems: REACTOME 2.518E-3 8.533E-3 4.007E-2
1.536E-1
 2 79
19 1268693 Protein folding BioSystems: REACTOME 4.401E-3 1.413E-2
6.635E-2
2.684E-1
 2 105
20 1268851 Trafficking of myristoylated proteins to the cilium BioSystems: REACTOME 5.770E-3 1.760E-2
8.265E-2
3.520E-1
 1 6
21 1311074 Phospholipase D signaling pathway BioSystems: KEGG 8.346E-3 2.424E-2
1.139E-1
5.091E-1
 2 146
22 1457804 MET receptor recycling BioSystems: REACTOME 9.600E-3 2.546E-2
1.196E-1
5.856E-1
 1 10
23 1269105 Nef Mediated CD4 Down-regulation BioSystems: REACTOME 9.600E-3 2.546E-2
1.196E-1
5.856E-1
 1 10
24 1268846 Cilium Assembly BioSystems: REACTOME 1.411E-2 3.585E-2
1.684E-1
8.605E-1
 2 192
25 1270053 Phospholipid metabolism BioSystems: REACTOME 1.642E-2 4.007E-2
1.882E-1
1.000E0
 2 208
26 137927 Arf1 pathway BioSystems: Pathway Interaction Database 1.722E-2 4.040E-2
1.897E-1
1.000E0
 1 18
27 138021 Paxillin-dependent events mediated by a4b1 BioSystems: Pathway Interaction Database 1.817E-2 4.105E-2
1.928E-1
1.000E0
 1 19
28 1268849 VxPx cargo-targeting to cilium BioSystems: REACTOME 2.101E-2 4.185E-2
1.965E-1
1.000E0
 1 22
29 137971 Paxillin-independent events mediated by a4b1 and a4b7 BioSystems: Pathway Interaction Database 2.101E-2 4.185E-2
1.965E-1
1.000E0
 1 22
30 1269102 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters BioSystems: REACTOME 2.101E-2 4.185E-2
1.965E-1
1.000E0
 1 22
31 1268700 Post-chaperonin tubulin folding pathway BioSystems: REACTOME 2.195E-2 4.185E-2
1.965E-1
1.000E0
 1 23
32 M8809 Phosphoinositides and their downstream targets. MSigDB C2 BIOCARTA (v6.0) 2.195E-2 4.185E-2
1.965E-1
1.000E0
 1 23
Show 27 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 766 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8195219 Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Pubmed 7.300E-26 5.592E-23 4.037E-22 5.592E-23 7 7
2 2105501 ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Pubmed 1.901E-18 7.280E-16 5.256E-15 1.456E-15 5 5
3 8947846 Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Pubmed 3.990E-17 1.019E-14 7.355E-14 3.057E-14 5 7
4 8491770 Two distinct populations of ARF bound to Golgi membranes. Pubmed 8.066E-15 1.545E-12 1.115E-11 6.178E-12 4 4
5 11950392 GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. Pubmed 2.821E-13 4.322E-11 3.120E-10 2.161E-10 4 7
6 8355790 Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Pubmed 5.642E-13 7.203E-11 5.200E-10 4.322E-10 4 8
7 10828067 Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. Pubmed 1.692E-12 1.851E-10 1.337E-9 1.296E-9 4 10
8 1447192 Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae. Pubmed 3.080E-11 2.622E-9 1.893E-8 2.360E-8 3 3
9 23783033 ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. Pubmed 3.080E-11 2.622E-9 1.893E-8 2.360E-8 3 3
10 15679100 The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton. Pubmed 1.232E-10 8.578E-9 6.193E-8 9.436E-8 3 4
11 10589680 Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Pubmed 1.232E-10 8.578E-9 6.193E-8 9.436E-8 3 4
12 9038142 Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. Pubmed 3.079E-10 1.685E-8 1.216E-7 2.359E-7 3 5
13 17804820 ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Pubmed 3.079E-10 1.685E-8 1.216E-7 2.359E-7 3 5
14 10749932 A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. Pubmed 3.079E-10 1.685E-8 1.216E-7 2.359E-7 3 5
15 24768165 WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Pubmed 6.157E-10 3.144E-8 2.270E-7 4.716E-7 3 6
16 10022920 Identification of a new Pyk2 target protein with Arf-GAP activity. Pubmed 1.077E-9 5.157E-8 3.723E-7 8.252E-7 3 7
17 11926829 Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3. Pubmed 1.723E-9 7.334E-8 5.294E-7 1.320E-6 3 8
18 17398095 The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Pubmed 1.723E-9 7.334E-8 5.294E-7 1.320E-6 3 8
19 18597672 Arf family GTP loading is activated by, and generates, positive membrane curvature. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
20 1899243 Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
21 7990966 Structure of the human ADP-ribosylation factor 1 complexed with GDP. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
22 22971977 ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
23 19359423 ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
24 11278939 Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
25 22105072 Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
26 1993656 Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
27 26427472 The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
28 7898460 ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
29 22002721 Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
30 2474826 Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
31 24916416 Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
32 1577740 Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
33 17127620 Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
34 25773595 Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
35 8661066 Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
36 16669702 A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis. Pubmed 1.069E-7 2.276E-6 1.643E-5 8.192E-5 2 2
37 10623590 Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
38 27481943 Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
39 20921225 Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
40 19327349 Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
41 10980193 ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
42 22185782 GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
43 12799371 ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
44 10593962 Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
45 22573888 ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
46 9417041 ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
47 22962618 Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
48 17956946 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
49 25114232 EFA6 controls Arf1 and Arf6 activation through a negative feedback loop. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
50 11535061 Arfophilin is a common target of both class II and class III ADP-ribosylation factors. Pubmed 3.208E-7 4.311E-6 3.112E-5 2.457E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 553 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CYTH2 CYTH2 interactions 2.446E-11 1.353E-8 9.325E-8 1.353E-8 5 34
2 int:ARFIP2 ARFIP2 interactions 6.570E-11 1.817E-8 1.252E-7 3.633E-8 5 41
3 int:CYTH1 CYTH1 interactions 1.269E-9 2.339E-7 1.613E-6 7.018E-7 4 22
4 int:GGA1 GGA1 interactions 2.064E-7 2.774E-5 1.912E-4 1.141E-4 4 75
5 int:RAB11FIP3 RAB11FIP3 interactions 2.508E-7 2.774E-5 1.912E-4 1.387E-4 3 18
6 int:LDHC LDHC interactions 7.965E-7 6.680E-5 4.605E-4 4.405E-4 3 26
7 int:ARF1 ARF1 interactions 8.978E-7 6.680E-5 4.605E-4 4.965E-4 4 108
8 int:DUSP22 DUSP22 interactions 9.663E-7 6.680E-5 4.605E-4 5.344E-4 4 110
9 int:ASAP2 ASAP2 interactions 1.118E-6 6.869E-5 4.735E-4 6.182E-4 3 29
10 int:LDHAL6A LDHAL6A interactions 1.374E-6 7.599E-5 5.238E-4 7.599E-4 3 31
11 int:LDHAL6B LDHAL6B interactions 2.178E-6 1.095E-4 7.548E-4 1.204E-3 3 36
12 int:GGA2 GGA2 interactions 3.493E-6 1.610E-4 1.110E-3 1.932E-3 3 42
13 int:STAU1 STAU1 interactions 3.858E-6 1.641E-4 1.131E-3 2.134E-3 5 361
14 int:GGA3 GGA3 interactions 4.923E-6 1.945E-4 1.341E-3 2.723E-3 3 47
15 int:ACADM ACADM interactions 6.696E-6 2.469E-4 1.702E-3 3.703E-3 3 52
16 int:ARFIP1 ARFIP1 interactions 9.325E-6 3.223E-4 2.222E-3 5.157E-3 3 58
17 int:PIP5K1A PIP5K1A interactions 1.033E-5 3.361E-4 2.317E-3 5.714E-3 3 60
18 int:AP3B1 AP3B1 interactions 2.026E-5 6.225E-4 4.291E-3 1.120E-2 3 75
19 int:ETFA ETFA interactions 3.274E-5 9.530E-4 6.570E-3 1.811E-2 3 88
20 int:CDC73 CDC73 interactions 3.494E-5 9.593E-4 6.613E-3 1.932E-2 4 272
21 int:CLN3 CLN3 interactions 3.741E-5 9.593E-4 6.613E-3 2.069E-2 3 92
22 int:ARL2BP ARL2BP interactions 3.865E-5 9.593E-4 6.613E-3 2.137E-2 2 13
23 int:AP1B1 AP1B1 interactions 3.990E-5 9.593E-4 6.613E-3 2.206E-2 3 94
24 int:AP3S2 AP3S2 interactions 5.199E-5 1.198E-3 8.258E-3 2.875E-2 2 15
25 int:ARL3 ARL3 interactions 8.453E-5 1.847E-3 1.273E-2 4.674E-2 2 19
26 int:UNC119 UNC119 interactions 8.684E-5 1.847E-3 1.273E-2 4.802E-2 3 122
27 int:ALPI ALPI interactions 9.388E-5 1.923E-3 1.325E-2
5.192E-2
 2 20
28 int:HTR2A HTR2A interactions 1.249E-4 2.466E-3 1.700E-2
6.904E-2
 2 23
29 int:LDHB LDHB interactions 1.799E-4 3.431E-3 2.365E-2
9.950E-2
 3 156
30 int:ARL4D ARL4D interactions 1.862E-4 3.431E-3 2.365E-2
1.029E-1
 2 28
31 int:PTPN1 PTPN1 interactions 2.085E-4 3.720E-3 2.564E-2
1.153E-1
 3 164
32 int:PDE6D PDE6D interactions 2.439E-4 4.214E-3 2.905E-2
1.349E-1
 2 32
33 int:ARF3 ARF3 interactions 2.595E-4 4.246E-3 2.927E-2
1.435E-1
 2 33
34 int:LDHA LDHA interactions 2.611E-4 4.246E-3 2.927E-2
1.444E-1
 3 177
35 int:ASAP1 ASAP1 interactions 3.448E-4 5.296E-3 3.651E-2
1.907E-1
 2 38
36 int:GOLGA4 GOLGA4 interactions 3.448E-4 5.296E-3 3.651E-2
1.907E-1
 2 38
37 int:MMS19 MMS19 interactions 3.737E-4 5.585E-3 3.850E-2
2.067E-1
 3 200
38 int:PSAT1 PSAT1 interactions 4.628E-4 6.735E-3 4.643E-2
2.559E-1
 2 44
39 int:PTPN18 PTPN18 interactions 5.282E-4 7.302E-3
5.034E-2
2.921E-1
 2 47
40 int:PLD1 PLD1 interactions 5.282E-4 7.302E-3
5.034E-2
2.921E-1
 2 47
41 int:PDCD1 PDCD1 interactions 6.466E-4 8.637E-3
5.954E-2
3.575E-1
 2 52
42 int:AP3D1 AP3D1 interactions 6.716E-4 8.637E-3
5.954E-2
3.714E-1
 2 53
43 int:SLC2A4 SLC2A4 interactions 6.716E-4 8.637E-3
5.954E-2
3.714E-1
 2 53
44 int:CHRM3 CHRM3 interactions 7.497E-4 9.212E-3
6.351E-2
4.146E-1
 2 56
45 int:NT5E NT5E interactions 7.497E-4 9.212E-3
6.351E-2
4.146E-1
 2 56
46 int:TGOLN2 TGOLN2 interactions 8.319E-4 1.000E-2
6.894E-2
4.600E-1
 2 59
47 int:AP1G1 AP1G1 interactions 9.182E-4 1.080E-2
7.448E-2
5.078E-1
 2 62
48 int:EIF2B1 EIF2B1 interactions 9.479E-4 1.092E-2
7.528E-2
5.242E-1
 2 63
49 int:KIF23 KIF23 interactions 1.040E-3 1.174E-2
8.090E-2
5.750E-1
 2 66
50 int:ARF4 ARF4 interactions 1.071E-3 1.185E-2
8.169E-2
5.925E-1
 2 67
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3p21.2-p21.1 3p21.2-p21.1 7.500E-4 9.750E-3 3.101E-2 9.750E-3 1 2
2 10q23.3 10q23.3 2.997E-3 1.620E-2
5.152E-2
 3.896E-2 1 8
3 7q31.3 7q31.3 5.612E-3 1.620E-2
5.152E-2
7.296E-2
 1 15
4 5q12.3 5q12.3 6.731E-3 1.620E-2
5.152E-2
8.751E-2
 1 18
5 12q23.2 12q23.2 6.731E-3 1.620E-2
5.152E-2
8.751E-2
 1 18
6 20q13.3 20q13.3 7.477E-3 1.620E-2
5.152E-2
9.720E-2
 1 20
7 14q21.3 14q21.3 1.045E-2 1.759E-2
5.594E-2
1.359E-1
 1 28
8 7p21.3 7p21.3 1.082E-2 1.759E-2
5.594E-2
1.407E-1
 1 29
9 1q42 1q42 1.268E-2 1.793E-2
5.701E-2
1.648E-1
 1 34
10 20q13.13 20q13.13 1.379E-2 1.793E-2
5.701E-2
1.793E-1
 1 37
11 12q13 12q13 2.631E-2 3.109E-2
9.888E-2
3.420E-1
 1 71
12 17q21.31 17q21.31 3.215E-2 3.483E-2
1.108E-1
4.179E-1
 1 87
13 11q13 11q13 4.373E-2 4.373E-2
1.391E-1
5.685E-1
 1 119
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 11 input genes in category / 137 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 13 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 357 ARF GTPase family genenames.org 6.697E-34 3.349E-33 7.646E-33 3.349E-33 12 31

13: Coexpression [Display Chart] 13 input genes in category / 1299 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19074878-SuppTable1 Human Leukemia Hillion08 1176genes GeneSigDB 1.598E-7 1.190E-4 9.219E-4 2.076E-4 5 247
2 M14636 Genes down-regulated during prostate cancer progression in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.832E-7 1.190E-4 9.219E-4 2.380E-4 3 21
3 18381418-Table1 Mouse Prostate Ouyang08 121genes GeneSigDB 1.333E-5 5.770E-3 4.470E-2 1.731E-2 3 85
4 M4535 Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by high-dose methotrexate (HDMTX) [PubChem=4112]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.987E-5 2.218E-2
1.718E-1
1.038E-1
 2 24
5 M8539 Genes up-regulated in CD8 T cells: KLRB1 int [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.218E-2
1.718E-1
2.218E-1
 3 200
6 M9560 Genes down-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=3398] knockout versus ID2 and BCL2L11 [GeneID=3398;10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.218E-2
1.718E-1
2.218E-1
 3 200
7 M6540 Genes down-regulated in epithelial cells (24h): interferon alpha versus interferon alpha and IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.218E-2
1.718E-1
2.218E-1
 3 200
8 M7325 Genes up-regulated in HMC-1 (mast leukemia) cells: untreated versus Cl-IB-MECA [PubChem=3035850]. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.218E-2
1.718E-1
2.218E-1
 3 200
9 M3531 Genes up-regulated in comparison of activated CD8 T cells from ELF4 [GeneID=2000] defficient mice versus those from wild type animals. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.218E-2
1.718E-1
2.218E-1
 3 200
10 M3220 Genes up-regulated in comparison of regulatory T cell (Treg) versus conventional T cells activated with lamina propria dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.218E-2
1.718E-1
2.218E-1
 3 200
11 15475436-Table5 Human StemCell Matar04 59genes GeneSigDB 3.106E-4 3.668E-2
2.841E-1
4.034E-1
 2 47
12 18820673-Table3 Human Liver Skawran08 62genes GeneSigDB 3.951E-4 4.277E-2
3.314E-1
5.133E-1
 2 53
Show 7 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 816 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 13 input genes in category / 93 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13925 MODULE 86 Small monomeric GTPases. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.671E-14 1.476E-12 7.550E-12 2.484E-12 7 43
2 M5631 MODULE 87 Genes in the cancer module 87. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.174E-14 1.476E-12 7.550E-12 2.952E-12 7 44
3 M14348 MODULE 226 Genes in the cancer module 226. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.921E-8 9.054E-7 4.631E-6 2.716E-6 4 27
4 M15268 MODULE 281 Phosphatase regulators. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.458E-6 1.269E-4 6.491E-4 5.076E-4 3 28
5 M18480 MODULE 159 Translation regulation. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.366E-4 2.541E-3 1.300E-2 1.271E-2 3 81
6 M5502 MODULE 371 Genes in the cancer module 371. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.946E-4 7.666E-3 3.921E-2 4.599E-2 2 26
7 M9350 MORF RAB1A Neighborhood of RAB1A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.763E-3 2.342E-2
1.198E-1
1.639E-1
 3 194
8 M5796 MORF RAC1 Neighborhood of RAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.242E-3 2.606E-2
1.333E-1
2.085E-1
 3 211
9 M1893 MORF DAP Neighborhood of DAP MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.399E-3 4.546E-2
2.325E-1
4.092E-1
 2 78
Show 4 more annotations

16: MicroRNA [Display Chart] 13 input genes in category / 579 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 7.089E-7 2.133E-4 1.480E-3 4.104E-4 4 411
2 hsa-miR-587:PITA hsa-miR-587:PITA TOP PITA 7.367E-7 2.133E-4 1.480E-3 4.265E-4 4 415
3 hsa-miR-520a-5p:PITA hsa-miR-520a-5p:PITA TOP PITA 1.155E-5 1.672E-3 1.160E-2 6.689E-3 3 251
4 hsa-miR-525-5p:PITA hsa-miR-525-5p:PITA TOP PITA 1.155E-5 1.672E-3 1.160E-2 6.689E-3 3 251
5 hsa-miR-219a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.802E-5 4.810E-3 3.338E-2 3.359E-2 2 63
6 hsa-miR-576-5p:PITA hsa-miR-576-5p:PITA TOP PITA 5.889E-5 4.810E-3 3.338E-2 3.410E-2 3 434
7 hsa-miR-520f:PITA hsa-miR-520f:PITA TOP PITA 6.642E-5 4.810E-3 3.338E-2 3.846E-2 3 452
8 hsa-miR-346:PITA hsa-miR-346:PITA TOP PITA 7.169E-5 4.810E-3 3.338E-2 4.151E-2 2 70
9 hsa-miR-1825:mirSVR highEffct hsa-miR-1825:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.983E-5 4.810E-3 3.338E-2 4.622E-2 3 481
10 hsa-miR-4429:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.908E-5 4.810E-3 3.338E-2
5.158E-2
 2 78
11 hsa-miR-320d:Functional MTI Functional MTI miRTarbase 9.138E-5 4.810E-3 3.338E-2
5.291E-2
 2 79
12 hsa-miR-219-1-3p:PITA hsa-miR-219-1-3p:PITA TOP PITA 1.378E-4 6.395E-3 4.438E-2
7.981E-2
 2 97
13 hsa-miR-448:Functional MTI Functional MTI miRTarbase 1.436E-4 6.395E-3 4.438E-2
8.314E-2
 2 99
14 hsa-miR-320c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.709E-4 7.067E-3 4.904E-2
9.893E-2
 2 108
15 hsa-miR-183-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.039E-4 7.759E-3
5.384E-2
1.181E-1
 2 118
16 hsa-miR-4452:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.144E-4 7.759E-3
5.384E-2
1.241E-1
 2 121
17 hsa-miR-383:PITA hsa-miR-383:PITA TOP PITA 2.747E-4 8.715E-3
6.048E-2
1.590E-1
 2 137
18 hsa-miR-632:PITA hsa-miR-632:PITA TOP PITA 2.827E-4 8.715E-3
6.048E-2
1.637E-1
 2 139
19 hsa-miR-4477a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.868E-4 8.715E-3
6.048E-2
1.661E-1
 2 140
20 hsa-miR-320b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.076E-4 8.715E-3
6.048E-2
1.781E-1
 2 145
21 hsa-miR-220b:PITA hsa-miR-220b:PITA TOP PITA 3.161E-4 8.715E-3
6.048E-2
1.830E-1
 2 147
22 hsa-miR-28-3p:PITA hsa-miR-28-3p:PITA TOP PITA 4.123E-4 1.085E-2
7.530E-2
2.387E-1
 2 168
23 hsa-miR-1206:PITA hsa-miR-1206:PITA TOP PITA 4.472E-4 1.126E-2
7.812E-2
2.589E-1
 2 175
24 hsa-miR-636:PITA hsa-miR-636:PITA TOP PITA 4.782E-4 1.154E-2
8.005E-2
2.769E-1
 2 181
25 hsa-miR-335:PITA hsa-miR-335:PITA TOP PITA 5.102E-4 1.182E-2
8.200E-2
2.954E-1
 2 187
26 hsa-miR-3646:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.830E-4 1.246E-2
8.648E-2
3.376E-1
 2 200
27 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 5.947E-4 1.246E-2
8.648E-2
3.443E-1
 2 202
28 hsa-miR-219b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.123E-4 1.246E-2
8.648E-2
3.545E-1
 2 205
29 hsa-miR-185:PITA hsa-miR-185:PITA TOP PITA 6.242E-4 1.246E-2
8.648E-2
3.614E-1
 2 207
30 hsa-miR-665:PITA hsa-miR-665:PITA TOP PITA 6.545E-4 1.263E-2
8.765E-2
3.789E-1
 2 212
31 hsa-miR-188-3p:PITA hsa-miR-188-3p:PITA TOP PITA 7.560E-4 1.412E-2
9.799E-2
4.377E-1
 2 228
32 hsa-miR-34c-3p:PITA hsa-miR-34c-3p:PITA TOP PITA 8.163E-4 1.477E-2
1.025E-1
4.726E-1
 2 237
33 hsa-miR-132-3p:Functional MTI Functional MTI miRTarbase 9.435E-4 1.655E-2
1.149E-1
5.463E-1
 2 255
34 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 9.954E-4 1.690E-2
1.173E-1
5.764E-1
 2 262
35 hsa-miR-633:PITA hsa-miR-633:PITA TOP PITA 1.026E-3 1.690E-2
1.173E-1
5.939E-1
 2 266
36 hsa-miR-222:PITA hsa-miR-222:PITA TOP PITA 1.056E-3 1.690E-2
1.173E-1
6.117E-1
 2 270
37 hsa-miR-221:PITA hsa-miR-221:PITA TOP PITA 1.080E-3 1.690E-2
1.173E-1
6.252E-1
 2 273
38 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 1.151E-3 1.754E-2
1.217E-1
6.665E-1
 2 282
39 hsa-miR-1911:mirSVR highEffct hsa-miR-1911:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.250E-3 1.758E-2
1.220E-1
7.237E-1
 2 294
40 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 1.250E-3 1.758E-2
1.220E-1
7.237E-1
 2 294
41 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 1.250E-3 1.758E-2
1.220E-1
7.237E-1
 2 294
42 hsa-miR-324-5p:Functional MTI Functional MTI miRTarbase 1.275E-3 1.758E-2
1.220E-1
7.383E-1
 2 297
43 hsa-miR-513b:PITA hsa-miR-513b:PITA TOP PITA 1.505E-3 2.026E-2
1.406E-1
8.712E-1
 2 323
44 hsa-miR-140-3p:PITA hsa-miR-140-3p:PITA TOP PITA 1.560E-3 2.053E-2
1.425E-1
9.034E-1
 2 329
45 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 1.694E-3 2.123E-2
1.473E-1
9.806E-1
 2 343
46 hsa-miR-1537:mirSVR highEffct hsa-miR-1537:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.723E-3 2.123E-2
1.473E-1
9.976E-1
 2 346
47 hsa-miR-361-3p:mirSVR highEffct hsa-miR-361-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.723E-3 2.123E-2
1.473E-1
9.976E-1
 2 346
48 hsa-miR-323a-3p:TargetScan hsa-miR-323a-3p TargetScan 1.883E-3 2.272E-2
1.576E-1
1.000E0
 2 362
49 hsa-miR-1539:mirSVR lowEffct hsa-miR-1539:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.008E-3 2.372E-2
1.646E-1
1.000E0
 2 374
50 hsa-miR-583:PITA hsa-miR-583:PITA TOP PITA 2.050E-3 2.374E-2
1.647E-1
1.000E0
 2 378
Show 45 more annotations

17: Drug [Display Chart] 13 input genes in category / 2614 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005287758 AC1NRA8N Stitch 7.572E-22 1.979E-18 1.672E-17 1.979E-18 11 190
2 CID010425705 lecithin Stitch 8.434E-15 1.102E-11 9.310E-11 2.205E-11 9 306
3 CID000091176 cnicin Stitch 2.293E-14 1.998E-11 1.687E-10 5.993E-11 7 92
4 CID005460104 phosphatidate Stitch 1.947E-13 1.272E-10 1.075E-9 5.089E-10 9 433
5 CID000000801 auxin Stitch 1.297E-11 6.778E-9 5.725E-8 3.389E-8 7 224
6 CID000168005 Te Al Stitch 3.270E-9 1.425E-6 1.203E-5 8.547E-6 4 35
7 CID000011161 glycylglycylglycine Stitch 5.698E-9 2.128E-6 1.797E-5 1.490E-5 4 40
8 CID006439287 brefeldin C Stitch 8.052E-9 2.631E-6 2.222E-5 2.105E-5 3 8
9 CID002733635 Fm 4-64 Stitch 1.640E-7 4.763E-5 4.023E-4 4.286E-4 4 91
10 CID000001088 sarcosine Stitch 2.399E-7 6.271E-5 5.297E-4 6.271E-4 4 100
11 CID000001754 4 OM Stitch 8.968E-7 1.954E-4 1.650E-3 2.344E-3 2 3
12 CID000446385 Sc 58272 Stitch 8.968E-7 1.954E-4 1.650E-3 2.344E-3 2 3
13 ctd:D002713 Chlorine CTD 1.223E-6 2.459E-4 2.076E-3 3.196E-3 5 368
14 CID000127532 N-succinimidyl-S-acetylthioacetate Stitch 1.406E-6 2.625E-4 2.217E-3 3.675E-3 3 40
15 CID006323367 He-O Stitch 2.614E-6 4.555E-4 3.847E-3 6.832E-3 3 49
16 CID000445622 FT T Stitch 2.952E-6 4.823E-4 4.074E-3 7.717E-3 3 51
17 6164 DN aspirin, USP; Down 200; 100uM; HL60; HT HG-U133A Broad Institute CMAP Down 3.261E-6 4.934E-4 4.167E-3 8.523E-3 4 192
18 6918 DN ICI182,780; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.398E-6 4.934E-4 4.167E-3 8.881E-3 4 194
19 CID005037551 NSC603722 Stitch 1.069E-5 1.471E-3 1.242E-2 2.794E-2 3 78
20 CID000002124 aluminum fluoride Stitch 1.219E-5 1.593E-3 1.346E-2 3.187E-2 4 268
21 CID009543520 triphosphoinositide Stitch 1.311E-5 1.632E-3 1.379E-2 3.427E-2 4 273
22 CID000011005 myristate Stitch 2.160E-5 2.567E-3 2.168E-2
5.647E-2
 4 310
23 ctd:D006220 Haloperidol CTD 3.247E-5 3.690E-3 3.117E-2
8.487E-2
 4 344
24 CID000075347 decanamide Stitch 9.334E-5 9.458E-3
7.988E-2
2.440E-1
 3 161
25 1280 UP Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.342E-4 9.458E-3
7.988E-2
3.508E-1
 3 182
26 6920 DN AG-012559 [369370-06-9]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.500E-4 9.458E-3
7.988E-2
3.922E-1
 3 189
27 4299 DN Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.548E-4 9.458E-3
7.988E-2
4.046E-1
 3 191
28 1165 UP trifluoperazine dihydrochloride; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.572E-4 9.458E-3
7.988E-2
4.108E-1
 3 192
29 3245 DN Fusaric acid [536-69-6]; Down 200; 22.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.572E-4 9.458E-3
7.988E-2
4.108E-1
 3 192
30 6722 DN Benserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.621E-4 9.458E-3
7.988E-2
4.236E-1
 3 194
31 5483 DN Ornidazole [16773-42-5]; Down 200; 18.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.621E-4 9.458E-3
7.988E-2
4.236E-1
 3 194
32 5017 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.621E-4 9.458E-3
7.988E-2
4.236E-1
 3 194
33 7481 DN (-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.621E-4 9.458E-3
7.988E-2
4.236E-1
 3 194
34 1783 DN Epivincamine [6835-99-0]; Down 200; 11.2uM; HL60; HG-U133A Broad Institute CMAP Down 1.645E-4 9.458E-3
7.988E-2
4.301E-1
 3 195
35 4820 DN Gabazine [105538-73-6]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.645E-4 9.458E-3
7.988E-2
4.301E-1
 3 195
36 6921 DN H-89, Dihydrochloride; Down 200; 0.5uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.645E-4 9.458E-3
7.988E-2
4.301E-1
 3 195
37 3001 DN Beclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.645E-4 9.458E-3
7.988E-2
4.301E-1
 3 195
38 CID000001335 4-dideoxy-1,4-imino-D-xylitol Stitch 1.670E-4 9.458E-3
7.988E-2
4.366E-1
 3 196
39 6905 DN Orlistat; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.670E-4 9.458E-3
7.988E-2
4.366E-1
 3 196
40 1327 DN Piperine [94-62-2]; Down 200; 14uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.670E-4 9.458E-3
7.988E-2
4.366E-1
 3 196
41 5350 DN Hesperetin [520-33-2]; Down 200; 13.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.696E-4 9.458E-3
7.988E-2
4.432E-1
 3 197
42 6219 UP Fluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.696E-4 9.458E-3
7.988E-2
4.432E-1
 3 197
43 6903 DN AH23848 hemicalcium salt hydrate; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.696E-4 9.458E-3
7.988E-2
4.432E-1
 3 197
44 4809 DN Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.721E-4 9.458E-3
7.988E-2
4.499E-1
 3 198
45 7066 DN SB 203580; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.747E-4 9.458E-3
7.988E-2
4.566E-1
 3 199
46 6249 DN Thiorphan [76721-89-6]; Down 200; 15.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.747E-4 9.458E-3
7.988E-2
4.566E-1
 3 199
47 7318 DN Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.747E-4 9.458E-3
7.988E-2
4.566E-1
 3 199
48 6356 DN Pinacidil [85371-64-8]; Down 200; 16.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.773E-4 9.458E-3
7.988E-2
4.634E-1
 3 200
49 6503 DN Remoxipride Hydrochloride [73220-03-8]; Down 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.773E-4 9.458E-3
7.988E-2
4.634E-1
 3 200
50 CID006857364 AC1OAGGW Stitch 1.852E-4 9.551E-3
8.067E-2
4.842E-1
 3 203
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 54 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1868720 Periventricular Nodular Heterotopia DisGeNET Curated 4.638E-5 2.505E-3 1.146E-2 2.505E-3 2 17
2 C0036117 Salmonella infections DisGeNET BeFree 2.135E-4 5.765E-3 2.638E-2 1.153E-2 2 36
3 C0431352 Secondary microcephaly DisGeNET BeFree 6.171E-4 6.665E-3 3.049E-2 3.332E-2 1 1
4 OMIN:608097 HETEROTOPIA, PERIVENTRICULAR, AUTOSOMAL RECESSIVE OMIM 6.171E-4 6.665E-3 3.049E-2 3.332E-2 1 1
5 cv:C1842563 Heterotopia, periventricular, autosomal recessive Clinical Variations 6.171E-4 6.665E-3 3.049E-2 3.332E-2 1 1
6 C0032962 Pregnancy Complications DisGeNET Curated 1.333E-3 1.200E-2
5.491E-2
7.201E-2
 2 90
7 C0917800 Epilepsy, Myoclonic, Infantile DisGeNET Curated 1.850E-3 1.249E-2
5.714E-2
9.991E-2
 1 3
8 C1842563 Heterotopia, Periventricular, Autosomal Recessive DisGeNET Curated 1.850E-3 1.249E-2
5.714E-2
9.991E-2
 1 3
9 C1848213 Periventricular Heterotopia, X-Linked DisGeNET Curated 2.466E-3 1.480E-2
6.771E-2
1.332E-1
 1 4
10 C1859564 Bardet-Biedl syndrome 3 DisGeNET Curated 3.082E-3 1.664E-2
7.615E-2
1.664E-1
 1 5
11 C0156221 Acute glomerulonephritis DisGeNET BeFree 3.697E-3 1.815E-2
8.305E-2
1.997E-1
 1 6
12 C1849173 Periventricular neuronal heterotopia DisGeNET Curated 4.927E-3 2.217E-2
1.014E-1
2.661E-1
 1 8
13 C0270790 Quadriparesis DisGeNET Curated 5.542E-3 2.302E-2
1.053E-1
2.992E-1
 1 9
14 C1445953 Poor eye contact DisGeNET Curated 7.383E-3 2.492E-2
1.140E-1
3.987E-1
 1 12
15 C0040425 Tonsillitis DisGeNET BeFree 7.383E-3 2.492E-2
1.140E-1
3.987E-1
 1 12
16 C0752123 Spinocerebellar Ataxia Type 5 DisGeNET Curated 7.383E-3 2.492E-2
1.140E-1
3.987E-1
 1 12
17 C0022118 Transient ischemia DisGeNET BeFree 9.220E-3 2.929E-2
1.340E-1
4.979E-1
 1 15
18 C0039128 Syphilis DisGeNET BeFree 1.289E-2 3.866E-2
1.769E-1
6.959E-1
 1 21
19 C0684276 Hypsarrhythmia DisGeNET Curated 1.532E-2 4.355E-2
1.993E-1
8.275E-1
 1 25
Show 14 more annotations