Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc86_18, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 51 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005160 transforming growth factor beta receptor binding 5.539E-48 2.825E-46 1.276E-45 2.825E-46 18 53
2 GO:0008083 growth factor activity 1.054E-34 2.688E-33 1.215E-32 5.376E-33 17 166
3 GO:0005126 cytokine receptor binding 1.542E-33 2.622E-32 1.185E-31 7.866E-32 18 289
4 GO:0005125 cytokine activity 1.833E-32 2.337E-31 1.056E-30 9.347E-31 17 222
5 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2.327E-9 2.374E-8 1.073E-7 1.187E-7 4 19
6 GO:0033612 receptor serine/threonine kinase binding 2.907E-9 2.471E-8 1.117E-7 1.483E-7 4 20
7 GO:0034711 inhibin binding 2.631E-8 1.917E-7 8.662E-7 1.342E-6 3 7
8 GO:0005114 type II transforming growth factor beta receptor binding 4.207E-8 2.682E-7 1.212E-6 2.146E-6 3 8
9 GO:0070700 BMP receptor binding 1.237E-7 7.012E-7 3.168E-6 6.311E-6 3 11
10 GO:0034714 type III transforming growth factor beta receptor binding 5.267E-6 2.686E-5 1.214E-4 2.686E-4 2 4
11 GO:0005179 hormone activity 2.172E-4 1.007E-3 4.551E-3 1.108E-2 3 124
12 GO:0070123 transforming growth factor beta receptor activity, type III 9.646E-4 3.514E-3 1.588E-2 4.919E-2 1 1
13 GO:0046789 host cell surface receptor binding 9.646E-4 3.514E-3 1.588E-2 4.919E-2 1 1
14 GO:0046812 host cell surface binding 9.646E-4 3.514E-3 1.588E-2 4.919E-2 1 1
15 GO:0046332 SMAD binding 2.463E-3 8.376E-3 3.785E-2
1.256E-1
 2 77
16 GO:0070699 type II activin receptor binding 2.891E-3 9.215E-3 4.164E-2
1.474E-1
 1 3
17 GO:0019955 cytokine binding 4.358E-3 1.307E-2
5.907E-2
2.222E-1
 2 103
18 GO:0047485 protein N-terminus binding 5.584E-3 1.582E-2
7.150E-2
2.848E-1
 2 117
19 GO:0070697 activin receptor binding 7.692E-3 2.065E-2
9.330E-2
3.923E-1
 1 8
20 GO:0039706 co-receptor binding 9.606E-3 2.227E-2
1.006E-1
4.899E-1
 1 10
21 GO:0005024 transforming growth factor beta-activated receptor activity 9.606E-3 2.227E-2
1.006E-1
4.899E-1
 1 10
22 GO:0034713 type I transforming growth factor beta receptor binding 9.606E-3 2.227E-2
1.006E-1
4.899E-1
 1 10
23 GO:0036122 BMP binding 1.056E-2 2.244E-2
1.014E-1
5.387E-1
 1 11
24 GO:0019211 phosphatase activator activity 1.056E-2 2.244E-2
1.014E-1
5.387E-1
 1 11
25 GO:0048185 activin binding 1.247E-2 2.544E-2
1.150E-1
6.360E-1
 1 13
26 GO:0050431 transforming growth factor beta binding 1.723E-2 3.254E-2
1.471E-1
8.787E-1
 1 18
27 GO:0004745 retinol dehydrogenase activity 1.723E-2 3.254E-2
1.471E-1
8.787E-1
 1 18
28 GO:0043539 protein serine/threonine kinase activator activity 2.007E-2 3.656E-2
1.652E-1
1.000E0
 1 21
29 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2.291E-2 4.029E-2
1.821E-1
1.000E0
 1 24
30 GO:0017134 fibroblast growth factor binding 2.574E-2 4.375E-2
1.977E-1
1.000E0
 1 27
31 GO:0042277 peptide binding 2.892E-2 4.757E-2
2.150E-1
1.000E0
 2 278
Show 26 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 1438 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060389 pathway-restricted SMAD protein phosphorylation 3.203E-46 4.606E-43 3.615E-42 4.606E-43 18 64
2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 1.074E-44 7.719E-42 6.058E-41 1.544E-41 17 49
3 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 8.862E-43 4.248E-40 3.334E-39 1.274E-39 17 61
4 GO:0060395 SMAD protein signal transduction 1.672E-42 6.011E-40 4.718E-39 2.404E-39 17 63
5 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7.126E-42 2.049E-39 1.608E-38 1.025E-38 18 105
6 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1.174E-35 2.813E-33 2.208E-32 1.688E-32 18 222
7 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 3.809E-32 7.826E-30 6.142E-29 5.478E-29 18 343
8 GO:0030509 BMP signaling pathway 9.215E-22 1.656E-19 1.300E-18 1.325E-18 12 151
9 GO:0071772 response to BMP 2.565E-21 3.688E-19 2.894E-18 3.688E-18 12 164
10 GO:0071773 cellular response to BMP stimulus 2.565E-21 3.688E-19 2.894E-18 3.688E-18 12 164
11 GO:0007179 transforming growth factor beta receptor signaling pathway 3.135E-12 4.098E-10 3.216E-9 4.508E-9 8 184
12 GO:0051216 cartilage development 5.434E-12 6.512E-10 5.111E-9 7.815E-9 8 197
13 GO:0071560 cellular response to transforming growth factor beta stimulus 1.885E-11 2.086E-9 1.637E-8 2.711E-8 8 230
14 GO:0071559 response to transforming growth factor beta 2.092E-11 2.149E-9 1.686E-8 3.008E-8 8 233
15 GO:0061035 regulation of cartilage development 2.818E-11 2.702E-9 2.121E-8 4.053E-8 6 66
16 GO:0061448 connective tissue development 6.031E-11 5.421E-9 4.254E-8 8.673E-8 8 266
17 GO:0022602 ovulation cycle process 6.484E-10 5.485E-8 4.305E-7 9.324E-7 6 110
18 GO:0001503 ossification 1.657E-9 1.324E-7 1.039E-6 2.382E-6 8 404
19 GO:0042698 ovulation cycle 2.561E-9 1.938E-7 1.521E-6 3.683E-6 6 138
20 GO:0010717 regulation of epithelial to mesenchymal transition 5.352E-9 3.848E-7 3.020E-6 7.696E-6 5 70
21 GO:0046882 negative regulation of follicle-stimulating hormone secretion 7.572E-9 5.185E-7 4.070E-6 1.089E-5 3 5
22 GO:0060317 cardiac epithelial to mesenchymal transition 1.057E-8 6.910E-7 5.423E-6 1.520E-5 4 27
23 GO:0050678 regulation of epithelial cell proliferation 1.195E-8 7.473E-7 5.865E-6 1.719E-5 7 323
24 GO:0061036 positive regulation of cartilage development 1.891E-8 1.133E-6 8.892E-6 2.719E-5 4 31
25 GO:0046881 positive regulation of follicle-stimulating hormone secretion 2.647E-8 1.523E-6 1.195E-5 3.807E-5 3 7
26 GO:0045778 positive regulation of ossification 3.110E-8 1.720E-6 1.350E-5 4.472E-5 5 99
27 GO:0032278 positive regulation of gonadotropin secretion 4.233E-8 2.254E-6 1.769E-5 6.087E-5 3 8
28 GO:0050673 epithelial cell proliferation 4.444E-8 2.282E-6 1.791E-5 6.390E-5 7 391
29 GO:0046880 regulation of follicle-stimulating hormone secretion 6.346E-8 3.042E-6 2.387E-5 9.125E-5 3 9
30 GO:0032277 negative regulation of gonadotropin secretion 6.346E-8 3.042E-6 2.387E-5 9.125E-5 3 9
31 GO:0001837 epithelial to mesenchymal transition 7.208E-8 3.344E-6 2.624E-5 1.037E-4 5 117
32 GO:0008585 female gonad development 1.045E-7 4.626E-6 3.631E-5 1.503E-4 5 126
33 GO:0032924 activin receptor signaling pathway 1.062E-7 4.626E-6 3.631E-5 1.527E-4 4 47
34 GO:0050680 negative regulation of epithelial cell proliferation 1.222E-7 4.936E-6 3.874E-5 1.757E-4 5 130
35 GO:0046884 follicle-stimulating hormone secretion 1.245E-7 4.936E-6 3.874E-5 1.790E-4 3 11
36 GO:2000736 regulation of stem cell differentiation 1.270E-7 4.936E-6 3.874E-5 1.826E-4 5 131
37 GO:0046545 development of primary female sexual characteristics 1.270E-7 4.936E-6 3.874E-5 1.826E-4 5 131
38 GO:0046660 female sex differentiation 2.182E-7 8.257E-6 6.481E-5 3.138E-4 5 146
39 GO:0044060 regulation of endocrine process 2.337E-7 8.616E-6 6.763E-5 3.360E-4 4 57
40 GO:0032276 regulation of gonadotropin secretion 2.741E-7 9.855E-6 7.735E-5 3.942E-4 3 14
41 GO:0060986 endocrine hormone secretion 2.880E-7 1.010E-5 7.927E-5 4.141E-4 4 60
42 GO:0007548 sex differentiation 3.120E-7 1.068E-5 8.384E-5 4.487E-4 6 309
43 GO:0032274 gonadotropin secretion 6.131E-7 2.050E-5 1.609E-4 8.816E-4 3 18
44 GO:0001541 ovarian follicle development 6.738E-7 2.202E-5 1.728E-4 9.689E-4 4 74
45 GO:0014031 mesenchymal cell development 7.261E-7 2.275E-5 1.785E-4 1.044E-3 5 186
46 GO:0045683 negative regulation of epidermis development 7.276E-7 2.275E-5 1.785E-4 1.046E-3 3 19
47 GO:0030308 negative regulation of cell growth 8.067E-7 2.468E-5 1.937E-4 1.160E-3 5 190
48 GO:0048511 rhythmic process 8.409E-7 2.493E-5 1.957E-4 1.209E-3 6 366
49 GO:0048864 stem cell development 8.495E-7 2.493E-5 1.957E-4 1.222E-3 5 192
50 GO:0048762 mesenchymal cell differentiation 1.039E-6 2.989E-5 2.346E-4 1.494E-3 5 200
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043511 inhibin complex 7.071E-10 1.980E-8 7.775E-8 1.980E-8 3 3
2 GO:0043513 inhibin B complex 8.423E-7 7.861E-6 3.087E-5 2.358E-5 2 2
3 GO:0043512 inhibin A complex 8.423E-7 7.861E-6 3.087E-5 2.358E-5 2 2
4 GO:0034673 inhibin-betaglycan-ActRII complex 2.525E-6 1.768E-5 6.942E-5 7.071E-5 2 3
5 GO:0043509 activin A complex 9.443E-4 4.407E-3 1.731E-2 2.644E-2 1 1
6 GO:0048180 activin complex 9.443E-4 4.407E-3 1.731E-2 2.644E-2 1 1
7 GO:0031093 platelet alpha granule lumen 1.214E-3 4.857E-3 1.907E-2 3.400E-2 2 55
8 GO:0070724 BMP receptor complex 1.888E-3 6.607E-3 2.595E-2
5.286E-2
 1 2
9 GO:0031091 platelet alpha granule 2.244E-3 6.981E-3 2.741E-2
6.283E-2
 2 75
10 GO:0034774 secretory granule lumen 2.871E-3 8.038E-3 3.156E-2
8.038E-2
 2 85
11 GO:0060205 cytoplasmic vesicle lumen 4.261E-3 1.070E-2 4.203E-2
1.193E-1
 2 104
12 GO:0031983 vesicle lumen 4.587E-3 1.070E-2 4.203E-2
1.284E-1
 2 108
13 GO:0031012 extracellular matrix 7.896E-3 1.701E-2
6.679E-2
2.211E-1
 3 444
Show 8 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 1259 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000912 Sprengel anomaly 7.286E-6 8.666E-4 6.686E-3 9.173E-3 3 25
2 HP:0009378 Triangular shaped phalanges of the 5th finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
3 HP:0009850 Triangular shaped middle phalanges of the hand 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
4 HP:0009182 Triangular shaped middle phalanx of the 5th finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
5 HP:0009152 Abnormality of the epiphyses of the 5th finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
6 HP:0010578 Bracket epiphyses 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
7 HP:0010258 Bracket epiphyses of the middle phalanges of the hand 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
8 HP:0009372 Type A2 brachydactyly 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
9 HP:0009514 Bracket epiphysis of the middle phalanx of the 2nd finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
10 HP:0008096 Medially deviated second toe 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
11 HP:0004224 Abnormality of the epiphysis of the middle phalanx of the 5th finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
12 HP:0010229 Bracket epiphyses of the phalanges of the hand 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
13 HP:0009489 Bracket epiphyses of the 2nd finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
14 HP:0010326 Deviation of the 2nd toe 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
15 HP:0010038 Short 2nd metacarpal 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
16 HP:0009575 Triangular shaped middle phalanx of the 2nd finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
17 HP:0009383 Bracket epiphyses of the 5th finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
18 HP:0009204 Bracket epiphysis of the middle phalanx of the 5th finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
19 HP:0004602 Cervical C2/C3 vertebral fusion 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
20 HP:0009911 Abnormal temporal bone morphology 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
21 HP:0009500 Abnormality of the epiphysis of the middle phalanx of the 2nd finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
22 HP:0009546 Triangular shaped phalanges of the 2nd finger 1.514E-5 8.666E-4 6.686E-3 1.906E-2 2 4
23 HP:0006263 Abnormality of the epiphyses of the 2nd finger 2.522E-5 1.176E-3 9.072E-3 3.175E-2 2 5
24 HP:0010010 Abnormality of the 2nd metacarpal 2.522E-5 1.176E-3 9.072E-3 3.175E-2 2 5
25 HP:0010036 Aplasia/Hypoplasia of the 2nd metacarpal 2.522E-5 1.176E-3 9.072E-3 3.175E-2 2 5
26 HP:0010244 Abnormality of the epiphyses of the middle phalanges of the hand 2.522E-5 1.176E-3 9.072E-3 3.175E-2 2 5
27 HP:0010319 Abnormality of the 2nd toe 2.522E-5 1.176E-3 9.072E-3 3.175E-2 2 5
28 HP:0009464 Ulnar deviation of the 2nd finger 3.779E-5 1.699E-3 1.311E-2 4.758E-2 2 6
29 HP:0009467 Radial deviation of the 2nd finger 5.286E-5 2.219E-3 1.712E-2
6.656E-2
 2 7
30 HP:0010194 Aplasia/Hypoplasia of the middle phalanges of the toes 5.286E-5 2.219E-3 1.712E-2
6.656E-2
 2 7
31 HP:0005988 Congenital muscular torticollis 7.043E-5 2.860E-3 2.207E-2
8.867E-2
 2 8
32 HP:0100240 Synostosis of joints 8.093E-5 3.164E-3 2.441E-2
1.019E-1
 4 160
33 HP:0002105 Hemoptysis 8.705E-5 3.164E-3 2.441E-2
1.096E-1
 4 163
34 HP:0009568 Aplasia/Hypoplasia of the middle phalanx of the 2nd finger 9.047E-5 3.164E-3 2.441E-2
1.139E-1
 2 9
35 HP:0009543 Abnormality of the middle phalanx of the 2nd finger 9.047E-5 3.164E-3 2.441E-2
1.139E-1
 2 9
36 HP:0009468 Deviation of the 2nd finger 9.047E-5 3.164E-3 2.441E-2
1.139E-1
 2 9
37 HP:0002948 Vertebral fusion 1.108E-4 3.648E-3 2.814E-2
1.395E-1
 3 61
38 HP:0003468 Abnormal vertebral morphology 1.129E-4 3.648E-3 2.814E-2
1.422E-1
 5 357
39 HP:0009552 Aplasia/Hypoplasia of the phalanges of the 2nd finger 1.130E-4 3.648E-3 2.814E-2
1.423E-1
 2 10
40 HP:0005640 Abnormal vertebral segmentation and fusion 1.380E-4 4.136E-3 3.191E-2
1.737E-1
 2 11
41 HP:0006264 Aplasia/Hypoplasia of the 2nd finger 1.380E-4 4.136E-3 3.191E-2
1.737E-1
 2 11
42 HP:0009536 Short 2nd finger 1.380E-4 4.136E-3 3.191E-2
1.737E-1
 2 11
43 HP:0009541 Abnormality of the phalanges of the 2nd finger 1.954E-4 5.466E-3 4.217E-2
2.460E-1
 2 13
44 HP:0007633 Bilateral microphthalmos 1.954E-4 5.466E-3 4.217E-2
2.460E-1
 2 13
45 HP:0010183 Abnormality of the middle phalanges of the toes 1.954E-4 5.466E-3 4.217E-2
2.460E-1
 2 13
46 HP:0002949 Fused cervical vertebrae 2.998E-4 8.205E-3
6.331E-2
3.774E-1
 2 16
47 HP:0006501 Aplasia/Hypoplasia of the radius 3.087E-4 8.269E-3
6.380E-2
3.887E-1
 3 86
48 HP:0000944 Abnormality of the metaphysis 4.115E-4 1.077E-2
8.306E-2
5.181E-1
 4 243
49 HP:0010109 Short hallux 4.261E-4 1.077E-2
8.306E-2
5.365E-1
 2 19
50 HP:0000782 Abnormality of the scapula 4.275E-4 1.077E-2
8.306E-2
5.383E-1
 3 96
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 17 input genes in category / 1252 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000550 abnormal forelimb morphology 2.794E-8 3.498E-5 2.697E-4 3.498E-5 7 219
2 MP:0004855 increased ovary weight 1.281E-7 8.021E-5 6.184E-4 1.604E-4 3 7
3 MP:0004805 absent oocytes 1.976E-7 8.245E-5 6.357E-4 2.474E-4 4 33
4 MP:0003967 abnormal follicle stimulating hormone level 3.144E-7 9.840E-5 7.587E-4 3.936E-4 5 94
5 MP:0009209 abnormal internal female genitalia morphology 4.212E-7 1.055E-4 8.131E-4 5.273E-4 8 494
6 MP:0001750 increased circulating follicle stimulating hormone level 7.776E-7 1.400E-4 1.080E-3 9.736E-4 4 46
7 MP:0003361 abnormal circulating gonadotropin level 7.892E-7 1.400E-4 1.080E-3 9.881E-4 5 113
8 MP:0005296 abnormal humerus morphology 9.790E-7 1.400E-4 1.080E-3 1.226E-3 5 118
9 MP:0005131 increased follicle stimulating hormone level 1.007E-6 1.400E-4 1.080E-3 1.260E-3 4 49
10 MP:0003854 abnormal forelimb stylopod morphology 1.203E-6 1.471E-4 1.134E-3 1.506E-3 5 123
11 MP:0009433 polyovular ovarian follicle 1.323E-6 1.471E-4 1.134E-3 1.657E-3 3 14
12 MP:0003855 abnormal forelimb zeugopod morphology 1.410E-6 1.471E-4 1.134E-3 1.765E-3 5 127
13 MP:0002016 ovary cysts 1.611E-6 1.551E-4 1.196E-3 2.016E-3 4 55
14 MP:0004359 short ulna 2.141E-6 1.787E-4 1.378E-3 2.680E-3 4 59
15 MP:0030900 decreased ulna size 2.141E-6 1.787E-4 1.378E-3 2.680E-3 4 59
16 MP:0005110 absent talus 2.537E-6 1.985E-4 1.531E-3 3.176E-3 2 2
17 MP:0004354 absent deltoid tuberosity 3.504E-6 2.487E-4 1.918E-3 4.387E-3 3 19
18 MP:0003362 increased circulating gonadotropin level 3.576E-6 2.487E-4 1.918E-3 4.477E-3 4 67
19 MP:0004601 abnormal vertebral spinous process morphology 4.800E-6 3.163E-4 2.439E-3 6.010E-3 3 21
20 MP:0000111 cleft palate 6.189E-6 3.549E-4 2.736E-3 7.748E-3 6 308
21 MP:0000454 abnormal jaw morphology 7.282E-6 3.549E-4 2.736E-3 9.118E-3 7 498
22 MP:0002209 decreased germ cell number 7.282E-6 3.549E-4 2.736E-3 9.118E-3 7 498
23 MP:0004832 enlarged ovary 7.283E-6 3.549E-4 2.736E-3 9.118E-3 3 24
24 MP:0003346 abnormal pectoral muscle morphology 7.603E-6 3.549E-4 2.736E-3 9.520E-3 2 3
25 MP:0004602 abnormal vertebral articular process morphology 7.603E-6 3.549E-4 2.736E-3 9.520E-3 2 3
26 MP:0020152 abnormal oocyte number 7.654E-6 3.549E-4 2.736E-3 9.582E-3 4 81
27 MP:0005431 decreased oocyte number 7.654E-6 3.549E-4 2.736E-3 9.582E-3 4 81
28 MP:0001126 abnormal ovary morphology 8.581E-6 3.837E-4 2.958E-3 1.074E-2 6 326
29 MP:0005116 abnormal circulating pituitary hormone level 9.948E-6 4.295E-4 3.311E-3 1.245E-2 5 189
30 MP:0003755 abnormal palate morphology 1.092E-5 4.558E-4 3.514E-3 1.367E-2 6 340
31 MP:0001935 decreased litter size 1.187E-5 4.795E-4 3.697E-3 1.486E-2 6 345
32 MP:0001933 abnormal litter size 1.398E-5 5.470E-4 4.217E-3 1.750E-2 6 355
33 MP:0003856 abnormal hindlimb stylopod morphology 1.442E-5 5.470E-4 4.218E-3 1.805E-2 5 204
34 MP:0013324 abnormal female reproductive gland morphology 1.563E-5 5.755E-4 4.437E-3 1.957E-2 6 362
35 MP:0005108 abnormal ulna morphology 1.770E-5 6.152E-4 4.743E-3 2.216E-2 4 100
36 MP:0004353 abnormal deltoid tuberosity morphology 1.770E-5 6.152E-4 4.743E-3 2.216E-2 3 32
37 MP:0001131 abnormal ovarian follicle morphology 1.818E-5 6.152E-4 4.743E-3 2.276E-2 5 214
38 MP:0003965 abnormal pituitary hormone level 2.219E-5 7.310E-4 5.636E-3 2.778E-2 5 223
39 MP:0006280 abnormal digit development 2.759E-5 8.667E-4 6.683E-3 3.454E-2 3 37
40 MP:0002679 abnormal corpus luteum morphology 2.769E-5 8.667E-4 6.683E-3 3.467E-2 4 112
41 MP:0001125 abnormal oocyte morphology 3.073E-5 9.384E-4 7.235E-3 3.847E-2 4 115
42 MP:0005117 increased circulating pituitary hormone level 3.289E-5 9.804E-4 7.559E-3 4.118E-2 4 117
43 MP:0006361 abnormal female germ cell morphology 3.753E-5 1.093E-3 8.426E-3 4.699E-2 4 121
44 MP:0000564 syndactyly 4.132E-5 1.176E-3 9.066E-3
5.174E-2
 4 124
45 MP:0004854 abnormal ovary weight 4.356E-5 1.212E-3 9.343E-3
5.453E-2
 3 43
46 MP:0004599 abnormal vertebral arch morphology 5.764E-5 1.536E-3 1.184E-2
7.217E-2
 4 135
47 MP:0003973 increased pituitary hormone level 5.764E-5 1.536E-3 1.184E-2
7.217E-2
 4 135
48 MP:0000556 abnormal hindlimb morphology 6.358E-5 1.658E-3 1.279E-2
7.960E-2
 6 464
49 MP:0004508 abnormal pectoral girdle bone morphology 6.722E-5 1.683E-3 1.298E-2
8.415E-2
 5 281
50 MP:0000150 abnormal rib morphology 6.722E-5 1.683E-3 1.298E-2
8.415E-2
 5 281
Show 45 more annotations

6: Domain [Display Chart] 18 input genes in category / 28 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR015615 TGF-beta-rel InterPro 8.446E-49 1.182E-47 4.644E-47 2.365E-47 17 32
2 IPR017948 TGFb CS InterPro 8.446E-49 1.182E-47 4.644E-47 2.365E-47 17 32
3 PF00019 TGF beta Pfam 2.374E-47 9.496E-47 3.729E-46 6.647E-46 17 37
4 SM00204 TGFB SMART 2.374E-47 9.496E-47 3.729E-46 6.647E-46 17 37
5 PS00250 TGF BETA 1 PROSITE 2.374E-47 9.496E-47 3.729E-46 6.647E-46 17 37
6 PS51362 TGF BETA 2 PROSITE 2.374E-47 9.496E-47 3.729E-46 6.647E-46 17 37
7 IPR001839 TGF-b C InterPro 2.374E-47 9.496E-47 3.729E-46 6.647E-46 17 37
8 IPR029034 Cystine-knot cytokine InterPro 5.024E-42 1.563E-41 6.139E-41 1.407E-40 17 67
9 2.10.90.10 - Gene3D 5.024E-42 1.563E-41 6.139E-41 1.407E-40 17 67
10 IPR001111 TGF-b N InterPro 1.634E-38 4.159E-38 1.633E-37 4.575E-37 14 28
11 PF00688 TGFb propeptide Pfam 1.634E-38 4.159E-38 1.633E-37 4.575E-37 14 28
12 IPR002405 Inhibin asu InterPro 8.535E-30 1.991E-29 7.821E-29 2.390E-28 10 13
13 IPR016319 TGF-beta InterPro 2.614E-6 5.630E-6 2.211E-5 7.319E-5 2 3
14 IPR015617 Growth differentiation fac-9 InterPro 9.608E-4 1.416E-3 5.560E-3 2.690E-2 1 1
15 IPR003939 TGFb1 InterPro 9.608E-4 1.416E-3 5.560E-3 2.690E-2 1 1
16 IPR015923 BMP-15 InterPro 9.608E-4 1.416E-3 5.560E-3 2.690E-2 1 1
17 IPR017175 Inhibin asu subgr InterPro 9.608E-4 1.416E-3 5.560E-3 2.690E-2 1 1
18 IPR000491 Inhibin betaA InterPro 9.608E-4 1.416E-3 5.560E-3 2.690E-2 1 1
19 IPR003940 TGFb2 InterPro 9.608E-4 1.416E-3 5.560E-3 2.690E-2 1 1
20 IPR017197 BMP3/BMP3B InterPro 1.921E-3 2.561E-3 1.006E-2
5.378E-2
 1 2
21 IPR000381 Inhibin betaB InterPro 1.921E-3 2.561E-3 1.006E-2
5.378E-2
 1 2
22 IPR001318 Inhibin betaC InterPro 2.880E-3 3.665E-3 1.439E-2
8.063E-2
 1 3
23 IPR017977 ZP dom CS InterPro 9.569E-3 1.165E-2 4.575E-2
2.679E-1
 1 10
24 PS51034 ZP 2 PROSITE 1.337E-2 1.498E-2
5.881E-2
3.744E-1
 1 14
25 PS00682 ZP 1 PROSITE 1.337E-2 1.498E-2
5.881E-2
3.744E-1
 1 14
26 SM00241 ZP SMART 1.432E-2 1.542E-2
6.056E-2
4.010E-1
 1 15
27 IPR001507 ZP dom InterPro 1.622E-2 1.622E-2
6.368E-2
4.540E-1
 1 17
28 PF00100 Zona pellucida Pfam 1.622E-2 1.622E-2
6.368E-2
4.540E-1
 1 17
Show 23 more annotations

7: Pathway [Display Chart] 18 input genes in category / 106 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00052 TGF-beta signaling pathway PantherDB 2.167E-30 2.297E-28 1.205E-27 2.297E-28 15 91
2 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 3.786E-26 2.007E-24 1.053E-23 4.013E-24 17 344
3 83064 TGF-beta signaling pathway BioSystems: KEGG 8.631E-16 3.050E-14 1.600E-13 9.149E-14 9 84
4 749777 Hippo signaling pathway BioSystems: KEGG 1.097E-9 2.907E-8 1.525E-7 1.163E-7 7 154
5 M17400 ALK in cardiac myocytes MSigDB C2 BIOCARTA (v6.0) 1.458E-9 3.092E-8 1.622E-7 1.546E-7 5 37
6 1270252 Molecules associated with elastic fibres BioSystems: REACTOME 9.391E-8 1.659E-6 8.703E-6 9.955E-6 4 31
7 1270251 Elastic fibre formation BioSystems: REACTOME 3.308E-7 5.009E-6 2.627E-5 3.506E-5 4 42
8 1268754 Glycoprotein hormones BioSystems: REACTOME 5.538E-7 7.337E-6 3.849E-5 5.870E-5 3 12
9 1268753 Peptide hormone biosynthesis BioSystems: REACTOME 9.146E-7 1.077E-5 5.650E-5 9.694E-5 3 14
10 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 1.468E-6 1.556E-5 8.160E-5 1.556E-4 6 270
11 M18215 Role of Tob in T-cell activation MSigDB C2 BIOCARTA (v6.0) 3.321E-6 3.200E-5 1.678E-4 3.520E-4 3 21
12 M11420 CTCF: First Multivalent Nuclear Factor MSigDB C2 BIOCARTA (v6.0) 4.414E-6 3.899E-5 2.045E-4 4.679E-4 3 23
13 137968 ALK1 signaling events BioSystems: Pathway Interaction Database 5.040E-6 4.109E-5 2.155E-4 5.342E-4 3 24
14 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 6.462E-6 4.893E-5 2.566E-4 6.850E-4 3 26
15 1269622 Antagonism of Activin by Follistatin BioSystems: REACTOME 1.183E-5 8.357E-5 4.383E-4 1.254E-3 2 4
16 1269621 Signaling by Activin BioSystems: REACTOME 1.526E-4 1.011E-3 5.301E-3 1.617E-2 2 13
17 M9367 Erythrocyte Differentiation Pathway MSigDB C2 BIOCARTA (v6.0) 2.050E-4 1.207E-3 6.333E-3 2.173E-2 2 15
18 M11736 Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. MSigDB C2 BIOCARTA (v6.0) 2.050E-4 1.207E-3 6.333E-3 2.173E-2 2 15
19 1268746 Peptide hormone metabolism BioSystems: REACTOME 2.847E-4 1.588E-3 8.332E-3 3.018E-2 3 91
20 M18933 TGF beta signaling pathway MSigDB C2 BIOCARTA (v6.0) 3.327E-4 1.763E-3 9.250E-3 3.527E-2 2 19
21 M648 Cell Cycle: G1/S Check Point MSigDB C2 BIOCARTA (v6.0) 7.299E-4 3.459E-3 1.815E-2
7.736E-2
 2 28
22 1270244 Extracellular matrix organization BioSystems: REACTOME 7.549E-4 3.459E-3 1.815E-2
8.002E-2
 4 298
23 M6910 Cytokines and Inflammatory Response MSigDB C2 BIOCARTA (v6.0) 7.832E-4 3.459E-3 1.815E-2
8.302E-2
 2 29
24 M4047 Selective expression of chemokine receptors during T-cell polarization MSigDB C2 BIOCARTA (v6.0) 7.832E-4 3.459E-3 1.815E-2
8.302E-2
 2 29
25 M12095 Signal transduction through IL1R MSigDB C2 BIOCARTA (v6.0) 1.015E-3 4.304E-3 2.258E-2
1.076E-1
 2 33
26 M862 p38 MAPK Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.491E-3 6.077E-3 3.188E-2
1.580E-1
 2 40
27 152665 Malaria BioSystems: KEGG 2.230E-3 8.756E-3 4.593E-2
2.364E-1
 2 49
28 790011 Ovarian steroidogenesis BioSystems: KEGG 2.321E-3 8.787E-3 4.609E-2
2.460E-1
 2 50
29 138024 TGF-beta receptor signaling BioSystems: Pathway Interaction Database 2.414E-3 8.823E-3 4.628E-2
2.559E-1
 2 51
30 1268901 TGFBR2 MSI Frameshift Mutants in Cancer BioSystems: REACTOME 2.890E-3 9.881E-3
5.183E-2
3.063E-1
 1 2
31 1269136 Influenza Virus Induced Apoptosis BioSystems: REACTOME 2.890E-3 9.881E-3
5.183E-2
3.063E-1
 1 2
32 1270256 ECM proteoglycans BioSystems: REACTOME 3.006E-3 9.958E-3
5.223E-2
3.186E-1
 2 57
33 83106 Colorectal cancer BioSystems: KEGG 3.325E-3 1.068E-2
5.603E-2
3.525E-1
 2 60
34 83108 Pancreatic cancer BioSystems: KEGG 3.774E-3 1.146E-2
6.010E-2
4.001E-1
 2 64
35 83107 Renal cell carcinoma BioSystems: KEGG 3.891E-3 1.146E-2
6.010E-2
4.124E-1
 2 65
36 842771 Inflammatory bowel disease (IBD) BioSystems: KEGG 3.891E-3 1.146E-2
6.010E-2
4.124E-1
 2 65
37 83116 Chronic myeloid leukemia BioSystems: KEGG 4.625E-3 1.325E-2
6.950E-2
4.902E-1
 2 71
38 144181 Leishmaniasis BioSystems: KEGG 4.883E-3 1.362E-2
7.144E-2
5.176E-1
 2 73
39 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 6.269E-3 1.690E-2
8.864E-2
6.645E-1
 2 83
40 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 6.868E-3 1.690E-2
8.864E-2
7.280E-1
 2 87
41 1268902 TGFBR2 Kinase Domain Mutants in Cancer BioSystems: REACTOME 7.209E-3 1.690E-2
8.864E-2
7.642E-1
 1 5
42 PW:0000330 Bone morphogenetic proteins signaling Pathway Ontology 7.209E-3 1.690E-2
8.864E-2
7.642E-1
 1 5
43 1268904 TGFBR1 LBD Mutants in Cancer BioSystems: REACTOME 7.209E-3 1.690E-2
8.864E-2
7.642E-1
 1 5
44 1268900 Loss of Function of TGFBR2 in Cancer BioSystems: REACTOME 7.209E-3 1.690E-2
8.864E-2
7.642E-1
 1 5
45 200309 Rheumatoid arthritis BioSystems: KEGG 7.334E-3 1.690E-2
8.864E-2
7.774E-1
 2 90
46 121494 Dilated cardiomyopathy BioSystems: KEGG 7.334E-3 1.690E-2
8.864E-2
7.774E-1
 2 90
47 167324 Amoebiasis BioSystems: KEGG 8.307E-3 1.874E-2
9.828E-2
8.806E-1
 2 96
48 1268898 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 8.645E-3 1.907E-2
1.000E-1
9.164E-1
 1 6
49 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 8.815E-3 1.907E-2
1.000E-1
9.344E-1
 2 99
50 147809 Chagas disease (American trypanosomiasis) BioSystems: KEGG 9.336E-3 1.979E-2
1.038E-1
9.896E-1
 2 102
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 9121 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15342483 TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Pubmed 2.321E-45 2.117E-41 2.053E-40 2.117E-41 16 53
2 20734064 A large-scale candidate gene association study of age at menarche and age at natural menopause. Pubmed 4.072E-36 1.857E-32 1.800E-31 3.714E-32 17 275
3 22560297 Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Pubmed 1.114E-27 3.388E-24 3.285E-23 1.016E-23 13 167
4 22847922 Regulation of the ovarian reserve by members of the transforming growth factor beta family. Pubmed 1.169E-24 2.667E-21 2.585E-20 1.067E-20 8 14
5 23303681 Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis. Pubmed 3.015E-20 5.500E-17 5.332E-16 2.750E-16 6 7
6 22682244 Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Pubmed 1.734E-19 2.637E-16 2.556E-15 1.582E-15 9 99
7 12666204 Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Pubmed 9.858E-19 1.284E-15 1.245E-14 8.991E-15 8 60
8 1373953 Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua. Pubmed 1.265E-17 1.443E-14 1.399E-13 1.154E-13 5 5
9 27465829 Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling. Pubmed 2.656E-16 2.692E-13 2.610E-12 2.423E-12 5 7
10 20359476 Genetic evidence that SOST inhibits WNT signaling in the limb. Pubmed 3.010E-14 2.745E-11 2.662E-10 2.745E-10 6 44
11 29031500 Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Pubmed 1.094E-13 9.069E-11 8.793E-10 9.976E-10 8 246
12 10844590 The family of bone morphogenetic proteins. Pubmed 1.725E-13 1.211E-10 1.174E-9 1.574E-9 4 5
13 10746731 Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Pubmed 1.725E-13 1.211E-10 1.174E-9 1.574E-9 4 5
14 14973287 HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Pubmed 1.207E-12 7.864E-10 7.625E-9 1.101E-8 4 7
15 14736745 The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Pubmed 4.343E-12 2.476E-9 2.400E-8 3.961E-8 4 9
16 1460021 Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. Pubmed 4.343E-12 2.476E-9 2.400E-8 3.961E-8 4 9
17 12651901 Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. Pubmed 7.236E-12 3.883E-9 3.764E-8 6.600E-8 4 10
18 23342175 Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. Pubmed 1.705E-11 8.638E-9 8.375E-8 1.555E-7 4 12
19 15963767 Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Pubmed 2.934E-11 1.409E-8 1.366E-7 2.676E-7 5 51
20 17881772 Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression. Pubmed 6.260E-11 2.055E-8 1.993E-7 5.710E-7 4 16
21 10320815 A novel role of activin in inflammation and repair. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
22 16621788 Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
23 18927237 Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
24 16423381 Inhibin/activin subunits beta-A (-betaA) and beta-B (-betaB) are differentially localised in normal, hyperplastic and malignant human endometrial tissue. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
25 3345731 Inhibin: definition and nomenclature, including related substances. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
26 18423626 High serum concentration of total inhibin in polycystic ovary syndrome. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
27 15374731 Serum inhibin A, inhibin B, pro-alphaC, and activin A levels in women with idiopathic premature ovarian failure. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
28 8606941 Implication of inhibin and related proteins in fetal development. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
29 15205401 Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
30 11344232 Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
31 12456957 The role of activin a in regulation of hemopoiesis. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
32 8606007 Strong induction of activin expression after injury suggests an important role of activin in wound repair. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
33 8330535 Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
34 17272393 Inhibin A and B in vitro bioactivities are modified by their degree of glycosylation and their affinities to betaglycan. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
35 17999987 Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
36 3754442 Structure of two human ovarian inhibins. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
37 2575216 Activin B: precursor sequences, genomic structure and in vitro activities. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
38 17071781 Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouse. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
39 7885473 Functional analysis of activins during mammalian development. Pubmed 8.789E-11 2.055E-8 1.993E-7 8.016E-7 3 3
40 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 1.011E-10 2.304E-8 2.234E-7 9.218E-7 7 331
41 28126904 Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic. Pubmed 1.332E-10 2.963E-8 2.873E-7 1.215E-6 4 19
42 21529351 Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
43 9482661 Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
44 17401695 Bone formation zones in heterotopic ossifications: histologic findings and increased expression of bone morphogenetic protein 2 and transforming growth factors beta2 and beta3. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
45 24599287 Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
46 18600473 Regulation of melanin synthesis by the TGF-beta family in B16 melanoma cells. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
47 20630504 A variant in the fibrillin-3 gene is associated with TGF-β and inhibin B levels in women with polycystic ovary syndrome. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
48 10092230 Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
49 11134153 Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
50 7720655 Gonadotropin-dependent and gonadotropin-independent development of inhibin subunit messenger ribonucleic acid levels in the mouse ovary. Pubmed 3.514E-10 6.048E-8 5.864E-7 3.206E-6 3 4
Show 45 more annotations

9: Interaction [Display Chart] 17 input genes in category / 399 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ACVR2A ACVR2A interactions 1.775E-17 7.080E-15 4.650E-14 7.080E-15 8 44
2 int:ENG ENG interactions 5.344E-15 1.066E-12 7.002E-12 2.132E-12 6 18
3 int:ACVR2B ACVR2B interactions 9.160E-12 1.218E-9 8.001E-9 3.655E-9 6 56
4 int:CHRDL2 CHRDL2 interactions 4.063E-11 3.487E-9 2.290E-8 1.621E-8 4 8
5 int:BMPR2 BMPR2 interactions 4.370E-11 3.487E-9 2.290E-8 1.744E-8 6 72
6 int:TGFBR3 TGFBR3 interactions 8.475E-11 5.636E-9 3.701E-8 3.381E-8 5 32
7 int:ACVR1 ACVR1 interactions 1.973E-10 1.125E-8 7.387E-8 7.873E-8 6 92
8 int:INHA INHA interactions 2.866E-10 1.430E-8 9.388E-8 1.144E-7 4 12
9 int:INHBA INHBA interactions 1.374E-9 6.092E-8 4.001E-7 5.483E-7 4 17
10 int:TGFB2 TGFB2 interactions 2.235E-9 8.918E-8 5.857E-7 8.918E-7 4 19
11 int:BMPR1B BMPR1B interactions 7.089E-9 2.571E-7 1.689E-6 2.828E-6 5 75
12 int:HTRA1 HTRA1 interactions 2.651E-8 8.814E-7 5.789E-6 1.058E-5 4 34
13 int:BMPR1A BMPR1A interactions 6.720E-8 2.062E-6 1.354E-5 2.681E-5 5 117
14 int:TDGF1 TDGF1 interactions 8.462E-8 2.412E-6 1.584E-5 3.376E-5 4 45
15 int:FST FST interactions 2.091E-7 5.562E-6 3.653E-5 8.344E-5 3 13
16 int:INHBB INHBB interactions 3.323E-7 8.286E-6 5.442E-5 1.326E-4 3 15
17 int:BMP2 BMP2 interactions 1.120E-6 2.629E-5 1.726E-4 4.469E-4 3 22
18 int:ACVRL1 ACVRL1 interactions 1.670E-6 3.701E-5 2.431E-4 6.662E-4 3 25
19 int:NOG NOG interactions 8.665E-6 1.820E-4 1.195E-3 3.457E-3 2 5
20 int:ACVR1B ACVR1B interactions 1.239E-5 2.468E-4 1.621E-3 4.942E-3 3 48
21 int:ACVR1C ACVR1C interactions 1.299E-5 2.468E-4 1.621E-3 5.183E-3 2 6
22 int:INHBC INHBC interactions 1.818E-5 3.153E-4 2.071E-3 7.252E-3 2 7
23 int:BMP15 BMP15 interactions 1.818E-5 3.153E-4 2.071E-3 7.252E-3 2 7
24 int:FMOD FMOD interactions 3.112E-5 4.967E-4 3.262E-3 1.242E-2 2 9
25 int:NREP NREP interactions 3.112E-5 4.967E-4 3.262E-3 1.242E-2 2 9
26 int:PZP PZP interactions 5.696E-5 8.742E-4 5.741E-3 2.273E-2 2 12
27 int:IGSF1 IGSF1 interactions 6.728E-5 9.725E-4 6.387E-3 2.685E-2 2 13
28 int:TGFB1 TGFB1 interactions 6.824E-5 9.725E-4 6.387E-3 2.723E-2 4 240
29 int:LTBP3 LTBP3 interactions 9.047E-5 1.203E-3 7.902E-3 3.610E-2 2 15
30 int:TGFB3 TGFB3 interactions 9.047E-5 1.203E-3 7.902E-3 3.610E-2 2 15
31 int:TGFBR2 TGFBR2 interactions 1.261E-4 1.624E-3 1.066E-2
5.033E-2
 3 104
32 int:CCN2 CCN2 interactions 2.170E-4 2.706E-3 1.777E-2
8.658E-2
 2 23
33 int:DCN DCN interactions 5.364E-4 6.486E-3 4.259E-2
2.140E-1
 2 36
34 int:FNTA FNTA interactions 8.018E-4 9.141E-3
6.003E-2
3.199E-1
 2 44
35 int:COL2A1 COL2A1 interactions 8.018E-4 9.141E-3
6.003E-2
3.199E-1
 2 44
36 int:TGFBR1 TGFBR1 interactions 8.470E-4 9.388E-3
6.165E-2
3.380E-1
 3 199
37 int:SIAE SIAE interactions 1.251E-3 1.349E-2
8.859E-2
4.991E-1
 2 55
38 int:GDF9 GDF9 interactions 1.343E-3 1.410E-2
9.260E-2
5.358E-1
 2 57
39 int:HECTD1 HECTD1 interactions 1.638E-3 1.676E-2
1.100E-1
6.535E-1
 2 63
40 int:HJV HJV interactions 1.920E-3 1.915E-2
1.258E-1
7.660E-1
 1 2
41 int:VASN VASN interactions 2.133E-3 2.075E-2
1.363E-1
8.509E-1
 2 72
42 int:GREM1 GREM1 interactions 2.878E-3 2.610E-2
1.714E-1
1.000E0
 1 3
43 int:GREM2 GREM2 interactions 2.878E-3 2.610E-2
1.714E-1
1.000E0
 1 3
44 int:MGP MGP interactions 2.878E-3 2.610E-2
1.714E-1
1.000E0
 1 3
45 int:DEFA1 DEFA1 interactions 3.165E-3 2.806E-2
1.843E-1
1.000E0
 2 88
46 int:SDC2 SDC2 interactions 3.527E-3 3.060E-2
2.009E-1
1.000E0
 2 93
47 int:C4orf48 C4orf48 interactions 3.836E-3 3.189E-2
2.094E-1
1.000E0
 1 4
48 int:BMPER BMPER interactions 3.836E-3 3.189E-2
2.094E-1
1.000E0
 1 4
49 int:DPT DPT interactions 4.793E-3 3.903E-2
2.563E-1
1.000E0
 1 5
50 int:GDF3 GDF3 interactions 5.749E-3 4.248E-2
2.790E-1
1.000E0
 1 6
Show 45 more annotations

10: Cytoband [Display Chart] 17 input genes in category / 16 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10q11.22 10q11.22 4.345E-4 3.924E-3 1.327E-2 6.952E-3 2 63
2 1p35-p32 1p35-p32 4.905E-4 3.924E-3 1.327E-2 7.847E-3 1 1
3 2q33-q36 2q33-q36 1.471E-3 5.883E-3 1.989E-2 2.353E-2 1 3
4 7p15-p13 7p15-p13 1.471E-3 5.883E-3 1.989E-2 2.353E-2 1 3
5 1p33-p32 1p33-p32 4.894E-3 1.566E-2
5.295E-2
7.831E-2
 1 10
6 20p12 20p12 6.846E-3 1.826E-2
6.172E-2
1.095E-1
 1 14
7 Xp11.2 Xp11.2 1.025E-2 2.148E-2
7.261E-2
1.640E-1
 1 21
8 12p13.1 12p13.1 1.074E-2 2.148E-2
7.261E-2
1.718E-1
 1 22
9 20q11.2 20q11.2 1.316E-2 2.340E-2
7.911E-2
2.106E-1
 1 27
10 6p12.1 6p12.1 1.607E-2 2.571E-2
8.691E-2
2.571E-1
 1 33
11 8q22.1 8q22.1 2.137E-2 3.108E-2
1.051E-1
3.419E-1
 1 44
12 19q13.1 19q13.1 2.664E-2 3.279E-2
1.109E-1
4.263E-1
 1 55
13 12q13.2 12q13.2 2.664E-2 3.279E-2
1.109E-1
4.263E-1
 1 55
14 5q31.1 5q31.1 3.141E-2 3.452E-2
1.167E-1
5.026E-1
 1 65
15 1q41 1q41 3.237E-2 3.452E-2
1.167E-1
5.178E-1
 1 67
16 19p12 19p12 4.419E-2 4.419E-2
1.494E-1
7.070E-1
 1 92
Show 11 more annotations

11: Transcription Factor Binding Site [Display Chart] 13 input genes in category / 128 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 14 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 542 Endogenous ligands genenames.org 1.605E-21 4.816E-21 8.829E-21 4.816E-21 12 237
2 455 Bone morphogenetic proteins|Endogenous ligands genenames.org 7.215E-11 1.082E-10 1.984E-10 2.165E-10 4 11
3 570 Proteoglycans|Structural maintenance of chromosomes proteins|Cohesin complex genenames.org 5.375E-3 5.375E-3 9.854E-3 1.612E-2 1 7

13: Coexpression [Display Chart] 18 input genes in category / 1657 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortTGF-betaFamilyMembers Human Immune Kong10 33genes ImmPort TGF-betaFamilyMembers GeneSigDB 4.813E-50 7.975E-47 6.372E-46 7.975E-47 17 33
2 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 5.486E-29 4.545E-26 3.632E-25 9.091E-26 17 433
3 19802007-SuppTable2 Human StemCell Novakova10 89genes CommonCytokines GeneSigDB 7.598E-25 4.197E-22 3.353E-21 1.259E-21 11 63
4 17823238-TableS4a Mouse EmbryonicStemCell Soh07 224genes A GeneSigDB 1.738E-14 7.199E-12 5.752E-11 2.880E-11 9 212
5 17823238-TableS4b Human EmbryonicStemCell Soh07 224genes B GeneSigDB 2.434E-14 8.066E-12 6.445E-11 4.033E-11 9 220
6 15696083-Table1 Human Lung Wang05 64genes GeneSigDB 3.093E-12 8.541E-10 6.825E-9 5.125E-9 6 57
7 17823238-TableS7a Human EmbryonicStemCell Soh07 27genes A GeneSigDB 1.859E-9 4.400E-7 3.516E-6 3.080E-6 4 22
8 20035976-Figure1D Human Prostate Furusato10 52genes LowGradeTumorEpithelialCells GeneSigDB 3.210E-9 4.835E-7 3.864E-6 5.319E-6 4 25
9 20035976-Figure1C Human Prostate Furusato10 52genes LowGradeTAStromalCells GeneSigDB 3.210E-9 4.835E-7 3.864E-6 5.319E-6 4 25
10 20035976-Figure1A Human Prostate Furusato10 52genes HighGradeTAStromalCells GeneSigDB 3.210E-9 4.835E-7 3.864E-6 5.319E-6 4 25
11 20035976-Figure1B Human Prostate Furusato10 52genes HighGradeTumorEpithelialCells GeneSigDB 3.210E-9 4.835E-7 3.864E-6 5.319E-6 4 25
12 11982591-Table1 Human Immune Frenkel 73genes GeneSigDB 1.793E-7 2.476E-5 1.978E-4 2.971E-4 4 66
13 16509772-TableS1 Human StemCell Coller06 136genes GeneSigDB 5.739E-7 7.315E-5 5.845E-4 9.510E-4 4 88
14 15950496-Table3b Human Leukemia Gebauer05 34genes GeneSigDB 2.330E-6 2.758E-4 2.204E-3 3.861E-3 3 34
15 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 3.784E-6 3.973E-4 3.175E-3 6.271E-3 4 141
16 20458058-TableS3b Human HeadandNeck Thurlow10 42genes GeneSigDB 3.836E-6 3.973E-4 3.175E-3 6.357E-3 3 40
17 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 4.229E-6 4.111E-4 3.285E-3 7.008E-3 4 145
18 M2782 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 [Gene ID=648] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 4.466E-6 4.111E-4 3.285E-3 7.400E-3 4 147
19 M2502 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.249E-6 5.450E-4 4.355E-3 1.036E-2 4 160
20 16585153-Table1 Mouse Skin Hagendoorn06 54genes GeneSigDB 8.531E-6 7.068E-4 5.648E-3 1.414E-2 3 52
21 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.437E-5 1.086E-3 8.679E-3 2.381E-2 5 425
22 M7258 Genes down-regulated in thymocytes: cortical versus medullary sources. MSigDB C7: Immunologic Signatures (v6.0) 1.478E-5 1.086E-3 8.679E-3 2.450E-2 4 199
23 M5950 Genes up-regulated during transplant rejection. MSigDB H: Hallmark Gene Sets (v6.0) 1.508E-5 1.086E-3 8.679E-3 2.498E-2 4 200
24 M1809 Genes important for cumulus expansion, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.051E-5 1.416E-3 1.132E-2 3.399E-2 2 9
25 16699793-Table2 Human pancreas Miyake06 72genes GeneSigDB 2.186E-5 1.449E-3 1.158E-2 3.622E-2 3 71
26 19224407-Table4 Human StemCell Menicanin09 13genes GeneSigDB 3.755E-5 2.393E-3 1.912E-2
6.223E-2
 2 12
27 19802007-Table2 Human StemCell Novakova10 21genes GeneSigDB 5.966E-5 3.484E-3 2.784E-2
9.886E-2
 2 15
28 15548695-Table2 Human Prostate Haudenschild04 18genes GeneSigDB 5.966E-5 3.484E-3 2.784E-2
9.886E-2
 2 15
29 M2352 Transcripts (mRNA molecules) rapidly degraded upon interaction with KHSRP [GeneID=8570]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.098E-5 3.484E-3 2.784E-2
1.010E-1
 3 100
30 17178894-Table1 Human Breast Fan06 104genes GeneSigDB 6.660E-5 3.678E-3 2.939E-2
1.104E-1
 3 103
31 M2223 Genes up-regulated in osteoblasts from wild type male mice compared to those with AR [GeneID=367] knockout. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.721E-5 4.127E-3 3.297E-2
1.279E-1
 2 17
32 17440099-Table3 Human StemCell Tsai07 19genes GeneSigDB 9.699E-5 5.022E-3 4.013E-2
1.607E-1
 2 19
33 M16756 Genes down-regulated in primary keratinocytes at 6 h after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.190E-4 5.975E-3 4.774E-2
1.972E-1
 2 21
34 M5813 Genes down-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] in SK-Hep-1 cells (hepatocellular carcinoma). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.432E-4 6.980E-3
5.578E-2
2.373E-1
 2 23
35 11965276-Table1 Human Sarcoma Nielsen02 36genes GeneSigDB 1.837E-4 8.699E-3
6.951E-2
3.045E-1
 2 26
36 M1538 Genes down-regulated in U2-OS Tet-On cells (osteosarcoma) after induction of ESX1 [GeneID=80712] expression. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.455E-4 1.119E-2
8.943E-2
4.068E-1
 2 30
37 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v6.0) 2.499E-4 1.119E-2
8.943E-2
4.141E-1
 3 161
38 14977634-Figure8b Rat Viral Sparmann04 52genes GeneSigDB 2.623E-4 1.144E-2
9.138E-2
4.346E-1
 2 31
39 M308 Genes up-regulated in response to both single dose and fractionated radiation that were common to all three cell lines studied. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.796E-4 1.188E-2
9.493E-2
4.634E-1
 2 32
40 15656974-Table1 Human Viral Jamshidi-Parsian05 42genes GeneSigDB 3.160E-4 1.309E-2
1.046E-1
5.236E-1
 2 34
41 M2771 Genes down-regulated during late stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 3.816E-4 1.542E-2
1.232E-1
6.324E-1
 3 186
42 M2787 Genes up-regulated upon knockdown of PTEN [Gene ID=5728] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 3.999E-4 1.578E-2
1.261E-1
6.627E-1
 3 189
43 M10480 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes down-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.164E-4 1.605E-2
1.282E-1
6.900E-1
 2 39
44 M3712 Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with poly(I:C) (TLR3 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 1.634E-2
1.306E-1
7.818E-1
 3 200
45 M5939 Genes involved in p53 pathways and networks. MSigDB H: Hallmark Gene Sets (v6.0) 4.718E-4 1.634E-2
1.306E-1
7.818E-1
 3 200
46 M9053 Genes up-regulated in Ly6C monocytes: high versus low. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 1.634E-2
1.306E-1
7.818E-1
 3 200
47 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v6.0) 4.718E-4 1.634E-2
1.306E-1
7.818E-1
 3 200
48 M8760 Genes silenced in HCT116 cells (colon cancer) by methylation of CpG islands in their promoters. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.832E-4 1.634E-2
1.306E-1
8.007E-1
 2 42
49 16495925-Table3 Human Breast Lombaerts06 43genes TGBFb GeneSigDB 4.832E-4 1.634E-2
1.306E-1
8.007E-1
 2 42
50 M9802 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 1 h time point that were not down-regulated at the previous time point, 30 min. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.393E-4 2.119E-2
1.693E-1
1.000E0
 3 222
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 1447 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Arv EB-LF 500 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 PCBC 8.003E-8 1.158E-4 9.096E-4 1.158E-4 7 499
2 Arv EB-LF 500 K2 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 k-means-cluster#2 PCBC 1.613E-6 1.055E-3 8.286E-3 2.335E-3 5 256
3 ratio EB vs SC 500 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 k-means-cluster#5 PCBC 2.187E-6 1.055E-3 8.286E-3 3.165E-3 4 116
4 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.070E-6 2.472E-3 1.941E-2 1.168E-2 5 356
5 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.988E-6 2.472E-3 1.941E-2 1.301E-2 5 364
6 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.025E-5 2.472E-3 1.941E-2 1.483E-2 5 374
7 Arv EB-LF 1000 K4 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 2.147E-5 4.439E-3 3.487E-2 3.107E-2 5 436
8 PCBC ratio EB vs SC 500 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 PCBC 4.097E-5 7.400E-3
5.813E-2
5.929E-2
 5 499
9 gudmap developingGonad e14.5 epididymis 1000 k4 DevelopingGonad e14.5 epididymis emap-29141 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.968E-5 7.400E-3
5.813E-2
7.188E-2
 4 256
10 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.114E-5 7.400E-3
5.813E-2
7.400E-2
 3 89
11 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.423E-4 1.786E-2
1.403E-1
2.058E-1
 4 336
12 gudmap dev gonad e12.5 M InterstitTestis Sma k2 500 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.577E-4 1.786E-2
1.403E-1
2.283E-1
 3 130
13 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.894E-4 1.786E-2
1.403E-1
2.740E-1
 4 362
14 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Testicular Germ Cell Tumor/4/2 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Testicular Germ Cell Tumor/4/2 TCGA-Testes 1.963E-4 1.786E-2
1.403E-1
2.841E-1
 3 140
15 gudmap developingKidney e13.5 podocyte cells 500 k1 DevelopingKidney e13.5 podocyte cells emap-27773 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.047E-4 1.786E-2
1.403E-1
2.962E-1
 3 142
16 gudmap dev gonad e12.5 F VasAssMesen MafB k2 100 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.063E-4 1.786E-2
1.403E-1
2.985E-1
 2 26
17 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.123E-4 1.786E-2
1.403E-1
3.073E-1
 4 373
18 gudmap dev gonad e13.5 M InterstitFLeydig MafB 200 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.222E-4 1.786E-2
1.403E-1
3.215E-1
 3 146
19 Facebase RNAseq e9.5 Olfactory Placode 2500 K5 FacebaseRNAseq e9.5 Olfactory Placode top-relative-expression-ranked 2500 k-means-cluster#5 FaceBase_RNAseq 2.542E-4 1.862E-2
1.462E-1
3.678E-1
 4 391
20 gudmap developingGonad e16.5 testes 100 k4 DevelopingGonad e16.5 testes emap-8444 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.573E-4 1.862E-2
1.462E-1
3.723E-1
 2 29
21 Sample Type by Project: Shred 1/TCGA-Thryoid/Thyroid Papillary Carcinoma/Classical/4/0 Sample Type by Project: Shred 1/TCGA-Thryoid/Thyroid Papillary Carcinoma/Classical/4/0 TCGA-Thryoid 3.127E-4 2.003E-2
1.573E-1
4.525E-1
 3 164
22 gudmap dev gonad e12.5 M InterstitLeydig MafB k2 500 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.183E-4 2.003E-2
1.573E-1
4.606E-1
 3 165
23 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup6/Calb1/Calb1,Rorb,Il1rapl2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup6/Calb1/Calb1,Rorb,Il1rapl2 BrainMap 3.183E-4 2.003E-2
1.573E-1
4.606E-1
 3 165
24 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k3 100 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.547E-4 2.093E-2
1.644E-1
5.132E-1
 2 34
25 gudmap developingGonad e14.5 epididymis 500 k4 DevelopingGonad e14.5 epididymis emap-29141 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.782E-4 2.093E-2
1.644E-1
5.473E-1
 3 175
26 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 500 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.242E-4 2.093E-2
1.644E-1
6.138E-1
 3 182
27 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg6 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg6 BrainMap 4.380E-4 2.093E-2
1.644E-1
6.338E-1
 3 184
28 gudmap developingGonad e14.5 testes 200 k2 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.436E-4 2.093E-2
1.644E-1
6.419E-1
 2 38
29 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma /Diffuse Malignant/4 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma /Diffuse Malignant/4 TCGA-Mesothelium 4.450E-4 2.093E-2
1.644E-1
6.439E-1
 3 185
30 PCBC ratio EB bone marrow vs EB blastocyst cfr-2X-p05 EB bone marrow vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.520E-4 2.093E-2
1.644E-1
6.540E-1
 4 455
31 gudmap dev gonad e12.5 F VasAssMesen MafB k1 200 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.673E-4 2.093E-2
1.644E-1
6.763E-1
 2 39
32 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3 BrainMap 4.884E-4 2.093E-2
1.644E-1
7.067E-1
 3 191
33 gudmap dev gonad e12.5 M InterstitTestis Sma k4 1000 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.884E-4 2.093E-2
1.644E-1
7.067E-1
 3 191
34 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k2 200 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.917E-4 2.093E-2
1.644E-1
7.115E-1
 2 40
35 gudmap developingGonad e18.5 testes 100 k3 DevelopingGonad e18.5 testes emap-11164 k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.167E-4 2.136E-2
1.678E-1
7.476E-1
 2 41
36 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.349E-4 2.552E-2
2.004E-1
9.187E-1
 3 209
37 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup2/Fezf2/Fezf2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup2/Fezf2/Fezf2 BrainMap 6.791E-4 2.589E-2
2.034E-1
9.827E-1
 2 47
38 gudmap developingGonad e16.5 testes 1000 k5 DevelopingGonad e16.5 testes emap-8444 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.800E-4 2.589E-2
2.034E-1
9.840E-1
 3 214
39 gudmap developingGonad P2 ovary 500 k1 DevelopingGonad P2 ovary emap-30224 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.381E-4 2.739E-2
2.151E-1
1.000E0
 2 49
40 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney NephrogenicRest Wilms PT-U/Kidney NephrogenicRest Wilms PT10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney NephrogenicRest Wilms PT-U/Kidney NephrogenicRest Wilms PT10 Adult, Development, and Cancer types 7.994E-4 2.863E-2
2.249E-1
1.000E0
 2 51
41 gudmap dev gonad e11.5 F GonMes Sma k3 200 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.310E-4 2.863E-2
2.249E-1
1.000E0
 2 52
42 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k1 200 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.310E-4 2.863E-2
2.249E-1
1.000E0
 2 52
43 gudmap dev gonad e12.5 F SupCellPrec Sry k2 200 dev gonad e12.5 F SupCellPrec Sry k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.293E-4 3.127E-2
2.456E-1
1.000E0
 2 55
44 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 500 k1 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.978E-4 3.281E-2
2.577E-1
1.000E0
 2 57
45 gudmap developingKidney e13.5 podocyte cells 1000 k3 DevelopingKidney e13.5 podocyte cells emap-27773 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.066E-3 3.362E-2
2.640E-1
1.000E0
 3 250
46 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup6/Pvalb/Pvalb,Chrm2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup6/Pvalb/Pvalb,Chrm2 BrainMap 1.069E-3 3.362E-2
2.640E-1
1.000E0
 2 59
47 gudmap dev gonad e12.5 M gudmap devVasTestis Flk k1 1000 dev gonad e12.5 M DevVasTestis Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.105E-3 3.402E-2
2.672E-1
1.000E0
 2 60
48 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 250 M-vs-F DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 M-vs-F top274 274 Gudmap Mouse MOE430.2 1.142E-3 3.442E-2
2.704E-1
1.000E0
 3 256
49 gudmap developingGonad e16.5 testes 200 k5 DevelopingGonad e16.5 testes emap-8444 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.179E-3 3.483E-2
2.736E-1
1.000E0
 2 62
50 gudmap developingGonad P2 testes 200 k4 DevelopingGonad P2 testes emap-30171 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.217E-3 3.523E-2
2.767E-1
1.000E0
 2 63
Show 45 more annotations

15: Computational [Display Chart] 10 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4082 MODULE 234 Bone remodeling. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.720E-5 4.476E-4 1.869E-3 6.193E-4 3 54
2 M7888 MODULE 433 Cytokines and GFs. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.487E-5 4.476E-4 1.869E-3 8.952E-4 3 61
3 M17631 MODULE 382 Peptide hormones. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.331E-4 3.997E-3 1.669E-2 1.199E-2 2 28
4 M2175 MODULE 129 Signaling. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.098E-3 9.880E-3 4.125E-2 3.952E-2 3 219
5 M14443 MODULE 147 GPCR. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.792E-3 3.450E-2
1.440E-1
1.725E-1
 2 107
6 M12600 MODULE 195 Breast cancer expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.876E-3 3.694E-2
1.542E-1
3.195E-1
 2 147
7 M10197 MODULE 92 Secreted signaling molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.110E-3 3.694E-2
1.542E-1
3.280E-1
 2 149
8 M16406 MODULE 356 Genes in the cancer module 356. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.229E-3 3.694E-2
1.542E-1
3.322E-1
 2 150
9 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.234E-3 3.694E-2
1.542E-1
3.324E-1
 3 464
Show 4 more annotations

16: MicroRNA [Display Chart] 18 input genes in category / 547 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-422a:Non-Functional MTI Non-Functional MTI miRTarbase 5.768E-5 2.160E-2
1.487E-1
 3.155E-2 2 45
2 hsa-miR-3690:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.135E-4 2.160E-2
1.487E-1
6.208E-2
 2 63
3 hsa-miR-4284:mirSVR highEffct hsa-miR-4284:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.168E-4 2.160E-2
1.487E-1
1.186E-1
 3 477
4 hsa-miR-7155-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.318E-4 2.160E-2
1.487E-1
1.268E-1
 2 90
5 hsa-miR-939:PITA hsa-miR-939:PITA TOP PITA 2.318E-4 2.160E-2
1.487E-1
1.268E-1
 2 90
6 hsa-miR-1233:PITA hsa-miR-1233:PITA TOP PITA 2.370E-4 2.160E-2
1.487E-1
1.296E-1
 2 91
7 hsa-miR-1471:mirSVR lowEffct hsa-miR-1471:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.918E-4 2.280E-2
1.569E-1
1.596E-1
 2 101
8 hsa-miR-1298-5p:TargetScan hsa-miR-1298-5p TargetScan 4.252E-4 2.762E-2
1.901E-1
2.326E-1
 2 122
9 hsa-miR-193a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 4.678E-4 2.762E-2
1.901E-1
2.559E-1
 2 128
10 hsa-miR-1275:PITA hsa-miR-1275:PITA TOP PITA 5.048E-4 2.762E-2
1.901E-1
2.762E-1
 2 133
11 hsa-miR-6826-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.018E-4 2.927E-2
2.014E-1
3.839E-1
 2 157
12 hsa-miR-378a-3p:TargetScan hsa-miR-378a-3p TargetScan 7.377E-4 2.927E-2
2.014E-1
4.035E-1
 2 161
13 hsa-miR-3127-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.652E-4 2.927E-2
2.014E-1
4.186E-1
 2 164
14 hsa-miR-1260:PITA hsa-miR-1260:PITA TOP PITA 7.745E-4 2.927E-2
2.014E-1
4.236E-1
 2 165
15 hsa-miR-136*:mirSVR highEffct hsa-miR-136*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.026E-4 2.927E-2
2.014E-1
4.390E-1
 2 168
16 hsa-miR-6756-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.405E-4 3.215E-2
2.213E-1
5.144E-1
 2 182
17 hsa-miR-382-3p:TargetScan hsa-miR-382-3p TargetScan 1.067E-3 3.342E-2
2.301E-1
5.837E-1
 2 194
18 TTTGCAG,MIR-518A-2:MSigDB TTTGCAG,MIR-518A-2:MSigDB MSigDB 1.100E-3 3.342E-2
2.301E-1
6.016E-1
 2 197
19 hsa-miR-144-3p:Functional MTI Functional MTI miRTarbase 1.248E-3 3.593E-2
2.473E-1
6.826E-1
 2 210
20 hsa-miR-142-5p:Functional MTI Functional MTI miRTarbase 1.430E-3 3.910E-2
2.691E-1
7.821E-1
 2 225
21 hsa-miR-874-3p:TargetScan hsa-miR-874-3p TargetScan 1.610E-3 3.957E-2
2.723E-1
8.809E-1
 2 239
22 hsa-miR-452-5p:TargetScan hsa-miR-452-5p TargetScan 1.664E-3 3.957E-2
2.723E-1
9.101E-1
 2 243
23 hsa-miR-892c-3p:TargetScan hsa-miR-892c-3p TargetScan 1.664E-3 3.957E-2
2.723E-1
9.101E-1
 2 243
24 hsa-miR-329-3p:TargetScan hsa-miR-329-3p TargetScan 1.886E-3 4.029E-2
2.773E-1
1.000E0
 2 259
25 hsa-miR-362-3p:TargetScan hsa-miR-362-3p TargetScan 1.886E-3 4.029E-2
2.773E-1
1.000E0
 2 259
26 hsa-miR-29b-3p:Functional MTI Functional MTI miRTarbase 1.915E-3 4.029E-2
2.773E-1
1.000E0
 2 261
27 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 2.245E-3 4.127E-2
2.841E-1
1.000E0
 2 283
28 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 2.245E-3 4.127E-2
2.841E-1
1.000E0
 2 283
29 TGCACTG,MIR-152:MSigDB TGCACTG,MIR-152:MSigDB MSigDB 2.339E-3 4.127E-2
2.841E-1
1.000E0
 2 289
30 TGCACTG,MIR-148B:MSigDB TGCACTG,MIR-148B:MSigDB MSigDB 2.339E-3 4.127E-2
2.841E-1
1.000E0
 2 289
31 TGCACTG,MIR-148A:MSigDB TGCACTG,MIR-148A:MSigDB MSigDB 2.339E-3 4.127E-2
2.841E-1
1.000E0
 2 289
32 hsa-miR-454*:mirSVR highEffct hsa-miR-454*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.667E-3 4.339E-2
2.986E-1
1.000E0
 2 309
33 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 2.718E-3 4.339E-2
2.986E-1
1.000E0
 2 312
34 hsa-miR-369-5p:Functional MTI Functional MTI miRTarbase 2.738E-3 4.339E-2
2.986E-1
1.000E0
 1 11
35 hsa-miR-548ah-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.838E-3 4.339E-2
2.986E-1
1.000E0
 2 319
36 hsa-miR-3609:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.856E-3 4.339E-2
2.986E-1
1.000E0
 2 320
37 hsa-miR-212-5p:TargetScan hsa-miR-212-5p TargetScan 2.961E-3 4.378E-2
3.013E-1
1.000E0
 2 326
38 hsa-miR-578:PITA hsa-miR-578:PITA TOP PITA 3.160E-3 4.457E-2
3.068E-1
1.000E0
 2 337
39 hsa-miR-324-3p:Functional MTI Functional MTI miRTarbase 3.178E-3 4.457E-2
3.068E-1
1.000E0
 2 338
40 GCGCCTT,MIR-525:MSigDB GCGCCTT,MIR-525:MSigDB MSigDB 3.483E-3 4.647E-2
3.198E-1
1.000E0
 1 14
41 GCGCCTT,MIR-524:MSigDB GCGCCTT,MIR-524:MSigDB MSigDB 3.483E-3 4.647E-2
3.198E-1
1.000E0
 1 14
42 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 3.811E-3 4.763E-2
3.278E-1
1.000E0
 2 371
43 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 3.811E-3 4.763E-2
3.278E-1
1.000E0
 2 371
44 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 3.831E-3 4.763E-2
3.278E-1
1.000E0
 2 372
Show 39 more annotations

17: Drug [Display Chart] 18 input genes in category / 4716 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005289552 alpha-D-glucose 1-phosphate 6-vanadate Stitch 5.801E-18 2.736E-14 2.472E-13 2.736E-14 9 88
2 CID000452221 AC1L9Q5W Stitch 1.157E-12 2.728E-9 2.465E-8 5.456E-9 7 106
3 ctd:D014260 Triclosan CTD 8.933E-11 1.404E-7 1.269E-6 4.213E-7 6 97
4 CID005318997 icariin Stitch 6.759E-10 7.969E-7 7.200E-6 3.187E-6 5 57
5 CID000003054 NSC19448 Stitch 9.177E-10 8.656E-7 7.821E-6 4.328E-6 7 273
6 CID000024441 calcium phosphate Stitch 1.212E-9 9.526E-7 8.608E-6 5.715E-6 6 149
7 CID000014781 hydroxyapatite Stitch 2.778E-9 1.872E-6 1.691E-5 1.310E-5 6 171
8 CID004369448 delta-(l-alpha-aminoadipoyl)-l-cysteinyl-glycine Stitch 1.639E-8 9.660E-6 8.729E-5 7.728E-5 6 230
9 CID000005293 AC1L1K15 Stitch 2.985E-8 1.564E-5 1.414E-4 1.408E-4 5 120
10 CID000114819 testosterone buciclate Stitch 3.442E-8 1.623E-5 1.467E-4 1.623E-4 3 9
11 ctd:D015034 Zinc Oxide CTD 1.120E-7 4.803E-5 4.340E-4 5.283E-4 6 318
12 CID000002795 detigon Stitch 1.859E-7 7.304E-5 6.600E-4 8.765E-4 3 15
13 CID004620597 Bmps Stitch 2.260E-7 8.198E-5 7.408E-4 1.066E-3 4 69
14 ctd:C027118 didecyldimethylammonium CTD 3.951E-7 1.331E-4 1.202E-3 1.863E-3 3 19
15 CID000104904 ecgonine methyl ester Stitch 6.912E-7 2.173E-4 1.964E-3 3.260E-3 4 91
16 CID000003379 AC1L1FSW Stitch 1.188E-6 3.295E-4 2.977E-3 5.602E-3 3 27
17 CID000005416 krypton Stitch 1.188E-6 3.295E-4 2.977E-3 5.602E-3 3 27
18 CID009858940 SB-505124 Stitch 1.330E-6 3.484E-4 3.148E-3 6.271E-3 3 28
19 CID003371862 AC1MONCM Stitch 1.646E-6 3.882E-4 3.508E-3 7.764E-3 3 30
20 CID005288255 Fr180204 Stitch 1.646E-6 3.882E-4 3.508E-3 7.764E-3 3 30
21 CID000006238 17-hydroxyprogesterone Stitch 2.311E-6 5.190E-4 4.690E-3 1.090E-2 4 123
22 CID000115239 SC-58125 Stitch 3.407E-6 6.963E-4 6.292E-3 1.607E-2 3 38
23 CID006332294 AC1O3MMZ Stitch 3.516E-6 6.963E-4 6.292E-3 1.658E-2 2 4
24 CID000002807 AC1L1EIK Stitch 3.987E-6 6.963E-4 6.292E-3 1.880E-2 3 40
25 ctd:C007997 25-hydroxycholesterol CTD 3.987E-6 6.963E-4 6.292E-3 1.880E-2 3 40
26 CID000004654 p-fluorophenylalanine Stitch 3.987E-6 6.963E-4 6.292E-3 1.880E-2 3 40
27 CID000123854 bis(sulfosuccinimidyl) suberate Stitch 3.987E-6 6.963E-4 6.292E-3 1.880E-2 3 40
28 CID000073965 MW 1 Stitch 5.226E-6 8.655E-4 7.820E-3 2.464E-2 4 151
29 CID000042615 Etilamide Stitch 5.333E-6 8.655E-4 7.820E-3 2.515E-2 3 44
30 ctd:C060540 polyhexamethyleneguanidine CTD 5.506E-6 8.655E-4 7.820E-3 2.596E-2 4 153
31 CID006449937 Dr 27 Stitch 5.857E-6 8.911E-4 8.052E-3 2.762E-2 2 5
32 CID000005409 AC1L1KAK Stitch 6.107E-6 9.000E-4 8.133E-3 2.880E-2 3 46
33 CID000092877 androstan-3-ol Stitch 6.573E-6 9.394E-4 8.488E-3 3.100E-2 4 160
34 CID000062924 Fluticaps Stitch 7.401E-6 1.027E-3 9.276E-3 3.490E-2 3 49
35 CID000451379 Ossirene Stitch 7.870E-6 1.060E-3 9.582E-3 3.711E-2 3 50
36 CID000067050 rhodizonic acid Stitch 8.355E-6 1.094E-3 9.889E-3 3.940E-2 4 170
37 ctd:C540596 1,2,5,6-tetrabromocyclooctane CTD 8.782E-6 1.119E-3 1.011E-2 4.142E-2 2 6
38 ctd:D015025 Zearalenone CTD 1.034E-5 1.271E-3 1.148E-2 4.878E-2 5 392
39 CID000057782 lisofylline Stitch 1.051E-5 1.271E-3 1.148E-2 4.955E-2 3 55
40 1231 DN 15d-PGJ2; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.094E-5 1.289E-3 1.165E-2
5.158E-2
 4 182
41 CID011957435 azafagomine Stitch 1.171E-5 1.293E-3 1.169E-2
5.521E-2
 3 57
42 CID000003026 di-n-butyl phthalate Stitch 1.171E-5 1.293E-3 1.169E-2
5.521E-2
 3 57
43 5420 UP Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.217E-5 1.293E-3 1.169E-2
5.739E-2
 4 187
44 CID000012733 CEES Stitch 1.234E-5 1.293E-3 1.169E-2
5.820E-2
 3 58
45 CID005288578 hydron;propane-1,3-diol Stitch 1.234E-5 1.293E-3 1.169E-2
5.820E-2
 3 58
46 CID005282188 miocamycin Stitch 1.299E-5 1.332E-3 1.204E-2
6.128E-2
 3 59
47 CID003348131 2-ketobenzothiazole 23 Stitch 1.367E-5 1.372E-3 1.240E-2
6.448E-2
 3 60
48 5665 DN Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.406E-5 1.382E-3 1.249E-2
6.633E-2
 4 194
49 CID000002193 AC1Q6O8T Stitch 1.494E-5 1.409E-3 1.273E-2
7.046E-2
 4 197
50 CID000449193 roflumilast Stitch 1.510E-5 1.409E-3 1.273E-2
7.119E-2
 3 62
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 1138 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3278509 Spinal fusion DisGeNET Curated 3.328E-8 3.787E-5 2.884E-4 3.787E-5 4 33
2 C0747102 Ovarian failure DisGeNET BeFree 7.400E-8 4.210E-5 3.206E-4 8.421E-5 4 40
3 cv:C3150968 Microphthalmia, isolated, with coloboma 6 Clinical Variations 1.036E-6 2.947E-4 2.244E-3 1.179E-3 2 2
4 C3150968 MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 6 DisGeNET Curated 1.036E-6 2.947E-4 2.244E-3 1.179E-3 2 2
5 C1862147 Medially deviated second toe DisGeNET Curated 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
6 C4024552 Triangular shaped middle phalanx of the 5th finger DisGeNET Curated 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
7 cv:C1832702 Brachydactyly type A2 Clinical Variations 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
8 C4024283 Triangular shaped middle phalanx of the 2nd finger DisGeNET Curated 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
9 OMIN:112600 BRACHYDACTYLY, TYPE A2; BDA2 OMIM 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
10 C4024536 Bracket epiphysis of the middle phalanx of the 5th finger DisGeNET Curated 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
11 C4024318 Bracket epiphysis of the middle phalanx of the 2nd finger DisGeNET Curated 3.106E-6 3.213E-4 2.447E-3 3.534E-3 2 3
12 C1867131 Broad hallux DisGeNET Curated 3.445E-6 3.267E-4 2.488E-3 3.921E-3 3 29
13 C1862144 Hypoplastic/aplastic middle phalanx (2nd finger) DisGeNET Curated 6.207E-6 4.155E-4 3.164E-3 7.064E-3 2 4
14 C1832702 BRACHYDACTYLY, TYPE A2 DisGeNET Curated 6.207E-6 4.155E-4 3.164E-3 7.064E-3 2 4
15 C1861689 KLIPPEL-FEIL SYNDROME, AUTOSOMAL DOMINANT DisGeNET Curated 6.207E-6 4.155E-4 3.164E-3 7.064E-3 2 4
16 C0022738 Klippel-Feil Syndrome DisGeNET Curated 6.207E-6 4.155E-4 3.164E-3 7.064E-3 2 4
17 C1834034 Absent/hypoplastic middle phalanx of 5th finger DisGeNET Curated 6.207E-6 4.155E-4 3.164E-3 7.064E-3 2 4
18 C4023976 Aplasia/Hypoplasia of the middle phalanges of the toes DisGeNET Curated 1.034E-5 5.603E-4 4.266E-3 1.177E-2 2 5
19 C0175700 Multiple synostosis syndrome DisGeNET Curated 1.034E-5 5.603E-4 4.266E-3 1.177E-2 2 5
20 C1844709 Second finger clinodactyly DisGeNET Curated 1.034E-5 5.603E-4 4.266E-3 1.177E-2 2 5
21 C1844891 Ulnar angulation of the index finger DisGeNET Curated 1.034E-5 5.603E-4 4.266E-3 1.177E-2 2 5
22 C0025322 Premature Menopause DisGeNET Curated 1.197E-5 6.192E-4 4.715E-3 1.362E-2 4 141
23 C1862142 Short index finger DisGeNET Curated 1.550E-5 7.669E-4 5.840E-3 1.764E-2 2 6
24 C0022548 Keloid DisGeNET Curated 2.172E-5 1.030E-3 7.841E-3 2.471E-2 4 164
25 C0085215 Ovarian Failure, Premature DisGeNET Curated 2.501E-5 1.138E-3 8.669E-3 2.846E-2 4 170
26 C1845877 Microphthalmia, Isolated, with Coloboma 1 DisGeNET Curated 3.713E-5 1.565E-3 1.192E-2 4.225E-2 2 9
27 C4025663 Abnormality of the tibia DisGeNET Curated 3.713E-5 1.565E-3 1.192E-2 4.225E-2 2 9
28 C0232939 Primary physiologic amenorrhea DisGeNET Curated 4.212E-5 1.712E-3 1.304E-2 4.794E-2 3 66
29 C4025662 Abnormality of the ulna DisGeNET Curated 4.638E-5 1.820E-3 1.386E-2
5.278E-2
 2 10
30 C0431122 Atypical meningioma DisGeNET BeFree 5.666E-5 2.149E-3 1.637E-2
6.447E-2
 2 11
31 C1859726 ARTERIAL TORTUOSITY SYNDROME DisGeNET Curated 6.795E-5 2.274E-3 1.732E-2
7.732E-2
 2 12
32 C0153687 Secondary malignant neoplasm of skin DisGeNET BeFree 6.795E-5 2.274E-3 1.732E-2
7.732E-2
 2 12
33 C0342549 Familial Testotoxicosis DisGeNET Curated 6.795E-5 2.274E-3 1.732E-2
7.732E-2
 2 12
34 C0429468 Anovulatory DisGeNET BeFree 6.795E-5 2.274E-3 1.732E-2
7.732E-2
 2 12
35 C4021790 Abnormality of the skeletal system DisGeNET Curated 7.495E-5 2.342E-3 1.783E-2
8.529E-2
 3 80
36 C0220620 Gastrointestinal Carcinoid Tumor DisGeNET BeFree 7.733E-5 2.342E-3 1.783E-2
8.800E-2
 4 227
37 C1834060 Short middle phalanx of the 5th finger DisGeNET Curated 8.025E-5 2.342E-3 1.783E-2
9.132E-2
 2 13
38 C2697932 Loeys-Dietz Syndrome DisGeNET Curated 8.025E-5 2.342E-3 1.783E-2
9.132E-2
 2 13
39 C0029899 Otosclerosis DisGeNET Curated 8.025E-5 2.342E-3 1.783E-2
9.132E-2
 2 13
40 C0158266 Intervertebral Disc Degeneration DisGeNET Curated 8.981E-5 2.535E-3 1.930E-2
1.022E-1
 3 85
41 C0750929 Arnold-Chiari Malformation, Type I DisGeNET Curated 9.357E-5 2.535E-3 1.930E-2
1.065E-1
 2 14
42 C1401084 Ovarian Insufficiency DisGeNET BeFree 9.357E-5 2.535E-3 1.930E-2
1.065E-1
 2 14
43 C0032460 Polycystic Ovary Syndrome DisGeNET Curated 1.029E-4 2.722E-3 2.073E-2
1.171E-1
 5 480
44 C0152171 Idiopathic pulmonary hypertension DisGeNET BeFree 1.137E-4 2.940E-3 2.239E-2
1.294E-1
 3 92
45 C1865992 Short hallux DisGeNET Curated 1.232E-4 3.116E-3 2.373E-2
1.402E-1
 2 16
46 C0595921 Intraocular pressure disorder DisGeNET BeFree 1.330E-4 3.291E-3 2.506E-2
1.514E-1
 3 97
47 C0268351 Cutis Laxa, Autosomal Recessive, Type I DisGeNET Curated 1.396E-4 3.309E-3 2.520E-2
1.588E-1
 2 17
48 C0267818 Bile duct proliferation DisGeNET Curated 1.396E-4 3.309E-3 2.520E-2
1.588E-1
 2 17
49 C3203102 Idiopathic pulmonary arterial hypertension DisGeNET Curated 1.691E-4 3.928E-3 2.991E-2
1.925E-1
 4 278
50 C3811653 Experimental Organism Basal Cell Carcinoma DisGeNET BeFree 1.886E-4 4.102E-3 3.123E-2
2.146E-1
 4 286
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