Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc89_17, positive side

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1: GO: Molecular Function [Display Chart] 16 input genes in category / 126 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030552 cAMP binding 1.494E-6 1.882E-4 1.020E-3 1.882E-4 3 27
2 GO:0030551 cyclic nucleotide binding 5.404E-6 3.405E-4 1.844E-3 6.809E-4 3 41
3 GO:0005131 growth hormone receptor binding 1.032E-5 4.333E-4 2.348E-3 1.300E-3 2 6
4 GO:0031730 CCR5 chemokine receptor binding 1.444E-5 4.548E-4 2.464E-3 1.819E-3 2 7
5 GO:0031625 ubiquitin protein ligase binding 7.099E-5 1.352E-3 7.325E-3 8.945E-3 4 273
6 GO:0001664 G protein-coupled receptor binding 7.407E-5 1.352E-3 7.325E-3 9.333E-3 4 276
7 GO:0044389 ubiquitin-like protein ligase binding 7.512E-5 1.352E-3 7.325E-3 9.465E-3 4 277
8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1.576E-4 2.483E-3 1.345E-2 1.986E-2 2 22
9 GO:0019903 protein phosphatase binding 2.247E-4 3.145E-3 1.704E-2 2.831E-2 3 142
10 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2.956E-4 3.618E-3 1.960E-2 3.725E-2 2 30
11 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3.159E-4 3.618E-3 1.960E-2 3.980E-2 2 31
12 GO:0048020 CCR chemokine receptor binding 4.511E-4 4.533E-3 2.456E-2
5.683E-2
 2 37
13 GO:0051427 hormone receptor binding 4.729E-4 4.533E-3 2.456E-2
5.958E-2
 3 183
14 GO:0019902 phosphatase binding 5.037E-4 4.533E-3 2.456E-2
6.347E-2
 3 187
15 GO:0050839 cell adhesion molecule binding 6.867E-4 5.495E-3 2.977E-2
8.653E-2
 3 208
16 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6.978E-4 5.495E-3 2.977E-2
8.793E-2
 2 46
17 GO:0042379 chemokine receptor binding 1.185E-3 8.783E-3 4.758E-2
1.493E-1
 2 60
18 GO:0005080 protein kinase C binding 1.265E-3 8.854E-3 4.796E-2
1.594E-1
 2 62
19 GO:0019962 type I interferon binding 1.714E-3 1.015E-2
5.500E-2
2.160E-1
 1 2
20 GO:0004905 type I interferon receptor activity 1.714E-3 1.015E-2
5.500E-2
2.160E-1
 1 2
21 GO:0035403 histone kinase activity (H3-T6 specific) 1.714E-3 1.015E-2
5.500E-2
2.160E-1
 1 2
22 GO:0005126 cytokine receptor binding 1.773E-3 1.015E-2
5.500E-2
2.234E-1
 3 289
23 GO:0030369 ICAM-3 receptor activity 2.570E-3 1.349E-2
7.310E-2
3.238E-1
 1 3
24 GO:0019961 interferon binding 2.570E-3 1.349E-2
7.310E-2
3.238E-1
 1 3
25 GO:0008081 phosphoric diester hydrolase activity 3.122E-3 1.574E-2
8.526E-2
3.934E-1
 2 98
26 GO:0019955 cytokine binding 3.442E-3 1.668E-2
9.037E-2
4.337E-1
 2 103
27 GO:0019784 NEDD8-specific protease activity 4.280E-3 1.740E-2
9.425E-2
5.393E-1
 1 5
28 GO:0019960 C-X3-C chemokine binding 4.280E-3 1.740E-2
9.425E-2
5.393E-1
 1 5
29 GO:0098639 collagen binding involved in cell-matrix adhesion 4.280E-3 1.740E-2
9.425E-2
5.393E-1
 1 5
30 GO:0004904 interferon receptor activity 4.280E-3 1.740E-2
9.425E-2
5.393E-1
 1 5
31 GO:0042015 interleukin-20 binding 4.280E-3 1.740E-2
9.425E-2
5.393E-1
 1 5
32 GO:0098634 cell-matrix adhesion mediator activity 5.134E-3 1.920E-2
1.040E-1
6.469E-1
 1 6
33 GO:0031698 beta-2 adrenergic receptor binding 5.134E-3 1.920E-2
1.040E-1
6.469E-1
 1 6
34 GO:0044325 ion channel binding 5.181E-3 1.920E-2
1.040E-1
6.528E-1
 2 127
35 GO:0042578 phosphoric ester hydrolase activity 5.407E-3 1.946E-2
1.054E-1
6.812E-1
 3 429
36 GO:0035184 histone threonine kinase activity 5.987E-3 2.096E-2
1.135E-1
7.544E-1
 1 7
37 GO:0008603 cAMP-dependent protein kinase regulator activity 6.840E-3 2.329E-2
1.262E-1
8.618E-1
 1 8
38 GO:0043023 ribosomal large subunit binding 7.692E-3 2.485E-2
1.346E-1
9.692E-1
 1 9
39 GO:0004862 cAMP-dependent protein kinase inhibitor activity 7.692E-3 2.485E-2
1.346E-1
9.692E-1
 1 9
40 GO:0031702 type 1 angiotensin receptor binding 8.543E-3 2.691E-2
1.458E-1
1.000E0
 1 10
41 GO:0004698 calcium-dependent protein kinase C activity 9.394E-3 2.887E-2
1.564E-1
1.000E0
 1 11
42 GO:0031701 angiotensin receptor binding 1.024E-2 3.041E-2
1.647E-1
1.000E0
 1 12
43 GO:0004713 protein tyrosine kinase activity 1.038E-2 3.041E-2
1.647E-1
1.000E0
 2 182
44 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding 1.194E-2 3.420E-2
1.853E-1
1.000E0
 1 14
45 GO:0034236 protein kinase A catalytic subunit binding 1.279E-2 3.581E-2
1.940E-1
1.000E0
 1 15
46 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1.448E-2 3.967E-2
2.149E-1
1.000E0
 1 17
47 GO:0098631 cell adhesion mediator activity 1.533E-2 4.024E-2
2.180E-1
1.000E0
 1 18
48 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1.533E-2 4.024E-2
2.180E-1
1.000E0
 1 18
49 GO:0010857 calcium-dependent protein kinase activity 1.617E-2 4.076E-2
2.208E-1
1.000E0
 1 19
50 GO:0035173 histone kinase activity 1.617E-2 4.076E-2
2.208E-1
1.000E0
 1 19
Show 45 more annotations

2: GO: Biological Process [Display Chart] 16 input genes in category / 1009 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060338 regulation of type I interferon-mediated signaling pathway 3.259E-8 3.288E-5 2.464E-4 3.288E-5 4 40
2 GO:0060337 type I interferon signaling pathway 5.808E-7 1.243E-4 9.319E-4 5.861E-4 4 81
3 GO:0071357 cellular response to type I interferon 6.103E-7 1.243E-4 9.319E-4 6.158E-4 4 82
4 GO:1901898 negative regulation of relaxation of cardiac muscle 6.920E-7 1.243E-4 9.319E-4 6.983E-4 2 2
5 GO:1901078 negative regulation of relaxation of muscle 6.920E-7 1.243E-4 9.319E-4 6.983E-4 2 2
6 GO:0034340 response to type I interferon 7.394E-7 1.243E-4 9.319E-4 7.461E-4 4 86
7 GO:0045765 regulation of angiogenesis 1.299E-6 1.873E-4 1.404E-3 1.311E-3 5 239
8 GO:0001525 angiogenesis 1.500E-6 1.892E-4 1.418E-3 1.514E-3 6 464
9 GO:0042493 response to drug 1.849E-6 2.073E-4 1.554E-3 1.866E-3 6 481
10 GO:1901342 regulation of vasculature development 2.119E-6 2.138E-4 1.602E-3 2.138E-3 5 264
11 GO:0001959 regulation of cytokine-mediated signaling pathway 5.647E-6 5.180E-4 3.882E-3 5.698E-3 4 143
12 GO:0060759 regulation of response to cytokine stimulus 6.647E-6 5.589E-4 4.188E-3 6.706E-3 4 149
13 GO:0043542 endothelial cell migration 9.716E-6 7.541E-4 5.652E-3 9.803E-3 4 164
14 GO:0045088 regulation of innate immune response 1.173E-5 8.452E-4 6.334E-3 1.183E-2 5 375
15 GO:1901897 regulation of relaxation of cardiac muscle 1.932E-5 1.300E-3 9.739E-3 1.949E-2 2 8
16 GO:0071404 cellular response to low-density lipoprotein particle stimulus 3.102E-5 1.956E-3 1.466E-2 3.130E-2 2 10
17 GO:1901077 regulation of relaxation of muscle 3.789E-5 2.228E-3 1.670E-2 3.823E-2 2 11
18 GO:0010631 epithelial cell migration 3.993E-5 2.228E-3 1.670E-2 4.029E-2 4 235
19 GO:0090132 epithelium migration 4.195E-5 2.228E-3 1.670E-2 4.233E-2 4 238
20 GO:0090130 tissue migration 4.623E-5 2.332E-3 1.748E-2 4.665E-2 4 244
21 GO:0071402 cellular response to lipoprotein particle stimulus 5.368E-5 2.579E-3 1.933E-2
5.417E-2
 2 13
22 GO:0031623 receptor internalization 5.648E-5 2.591E-3 1.942E-2
5.699E-2
 3 89
23 GO:0030593 neutrophil chemotaxis 6.236E-5 2.632E-3 1.972E-2
6.292E-2
 3 92
24 GO:0071872 cellular response to epinephrine stimulus 6.260E-5 2.632E-3 1.972E-2
6.316E-2
 2 14
25 GO:0070252 actin-mediated cell contraction 8.482E-5 3.389E-3 2.540E-2
8.558E-2
 3 102
26 GO:1990266 neutrophil migration 8.732E-5 3.389E-3 2.540E-2
8.811E-2
 3 103
27 GO:0009166 nucleotide catabolic process 9.780E-5 3.571E-3 2.676E-2
9.868E-2
 3 107
28 GO:0055119 relaxation of cardiac muscle 1.050E-4 3.571E-3 2.676E-2
1.060E-1
 2 18
29 GO:0071871 response to epinephrine 1.050E-4 3.571E-3 2.676E-2
1.060E-1
 2 18
30 GO:0071621 granulocyte chemotaxis 1.062E-4 3.571E-3 2.676E-2
1.071E-1
 3 110
31 GO:0006198 cAMP catabolic process 1.303E-4 4.123E-3 3.090E-2
1.315E-1
 2 20
32 GO:1901292 nucleoside phosphate catabolic process 1.308E-4 4.123E-3 3.090E-2
1.319E-1
 3 118
33 GO:0055094 response to lipoprotein particle 1.440E-4 4.144E-3 3.106E-2
1.452E-1
 2 21
34 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1.440E-4 4.144E-3 3.106E-2
1.452E-1
 2 21
35 GO:0097530 granulocyte migration 1.479E-4 4.144E-3 3.106E-2
1.492E-1
 3 123
36 GO:0001704 formation of primary germ layer 1.479E-4 4.144E-3 3.106E-2
1.492E-1
 3 123
37 GO:0030048 actin filament-based movement 1.551E-4 4.202E-3 3.149E-2
1.565E-1
 3 125
38 GO:0060330 regulation of response to interferon-gamma 1.583E-4 4.202E-3 3.149E-2
1.597E-1
 2 22
39 GO:0009214 cyclic nucleotide catabolic process 1.733E-4 4.482E-3 3.359E-2
1.748E-1
 2 23
40 GO:0001667 ameboidal-type cell migration 1.806E-4 4.555E-3 3.414E-2
1.822E-1
 4 347
41 GO:0045766 positive regulation of angiogenesis 1.863E-4 4.585E-3 3.436E-2
1.880E-1
 3 133
42 GO:1904018 positive regulation of vasculature development 2.604E-4 6.146E-3 4.606E-2
2.627E-1
 3 149
43 GO:0018108 peptidyl-tyrosine phosphorylation 2.688E-4 6.146E-3 4.606E-2
2.712E-1
 4 385
44 GO:0050900 leukocyte migration 2.714E-4 6.146E-3 4.606E-2
2.739E-1
 4 386
45 GO:0018212 peptidyl-tyrosine modification 2.741E-4 6.146E-3 4.606E-2
2.766E-1
 4 387
46 GO:0090075 relaxation of muscle 2.968E-4 6.511E-3 4.880E-2
2.995E-1
 2 30
47 GO:0086004 regulation of cardiac muscle cell contraction 3.172E-4 6.809E-3
5.103E-2
3.200E-1
 2 31
48 GO:0071870 cellular response to catecholamine stimulus 3.381E-4 7.108E-3
5.327E-2
3.412E-1
 2 32
49 GO:0043112 receptor metabolic process 3.514E-4 7.118E-3
5.334E-2
3.545E-1
 3 165
50 GO:0071868 cellular response to monoamine stimulus 3.598E-4 7.118E-3
5.334E-2
3.630E-1
 2 33
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 17 input genes in category / 121 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098636 protein complex involved in cell adhesion 3.209E-4 1.660E-2
8.924E-2
 3.883E-2 2 30
2 GO:0008305 integrin complex 3.209E-4 1.660E-2
8.924E-2
 3.883E-2 2 30
3 GO:0005891 voltage-gated calcium channel complex 6.015E-4 1.660E-2
8.924E-2
7.278E-2
 2 41
4 GO:0005912 adherens junction 7.512E-4 1.660E-2
8.924E-2
9.090E-2
 4 484
5 GO:0031594 neuromuscular junction 1.285E-3 1.660E-2
8.924E-2
1.555E-1
 2 60
6 GO:0034704 calcium channel complex 1.416E-3 1.660E-2
8.924E-2
1.714E-1
 2 63
7 GO:0005913 cell-cell adherens junction 1.647E-3 1.660E-2
8.924E-2
1.993E-1
 2 68
8 GO:0034665 integrin alpha1-beta1 complex 1.783E-3 1.660E-2
8.924E-2
2.157E-1
 1 2
9 GO:0034677 integrin alpha7-beta1 complex 1.783E-3 1.660E-2
8.924E-2
2.157E-1
 1 2
10 GO:0034667 integrin alpha3-beta1 complex 1.783E-3 1.660E-2
8.924E-2
2.157E-1
 1 2
11 GO:0034687 integrin alphaL-beta2 complex 1.783E-3 1.660E-2
8.924E-2
2.157E-1
 1 2
12 GO:0034681 integrin alpha11-beta1 complex 1.783E-3 1.660E-2
8.924E-2
2.157E-1
 1 2
13 GO:0034680 integrin alpha10-beta1 complex 1.783E-3 1.660E-2
8.924E-2
2.157E-1
 1 2
14 GO:0034678 integrin alpha8-beta1 complex 2.673E-3 2.022E-2
1.087E-1
3.235E-1
 1 3
15 GO:0034679 integrin alpha9-beta1 complex 2.673E-3 2.022E-2
1.087E-1
3.235E-1
 1 3
16 GO:0034666 integrin alpha2-beta1 complex 2.673E-3 2.022E-2
1.087E-1
3.235E-1
 1 3
17 GO:0045121 membrane raft 3.257E-3 2.189E-2
1.177E-1
3.941E-1
 3 343
18 GO:0098857 membrane microdomain 3.257E-3 2.189E-2
1.177E-1
3.941E-1
 3 343
19 GO:0033269 internode region of axon 3.563E-3 2.269E-2
1.220E-1
4.311E-1
 1 4
20 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 4.018E-3 2.431E-2
1.307E-1
4.862E-1
 2 107
21 GO:0005638 lamin filament 4.452E-3 2.565E-2
1.379E-1
5.387E-1
 1 5
22 GO:0071438 invadopodium membrane 5.340E-3 2.937E-2
1.579E-1
6.461E-1
 1 6
23 GO:0005911 cell-cell junction 5.664E-3 2.980E-2
1.602E-1
6.854E-1
 3 418
24 GO:0043219 lateral loop 6.227E-3 3.140E-2
1.688E-1
7.535E-1
 1 7
25 GO:0005952 cAMP-dependent protein kinase complex 7.114E-3 3.356E-2
1.805E-1
8.608E-1
 1 8
26 GO:0043197 dendritic spine 7.842E-3 3.356E-2
1.805E-1
9.489E-1
 2 151
27 GO:0019897 extrinsic component of plasma membrane 7.943E-3 3.356E-2
1.805E-1
9.611E-1
 2 152
28 GO:0035748 myelin sheath abaxonal region 8.000E-3 3.356E-2
1.805E-1
9.680E-1
 1 9
29 GO:0044309 neuron spine 8.044E-3 3.356E-2
1.805E-1
9.733E-1
 2 153
30 GO:0031588 nucleotide-activated protein kinase complex 8.885E-3 3.468E-2
1.865E-1
1.000E0
 1 10
31 GO:0030056 hemidesmosome 8.885E-3 3.468E-2
1.865E-1
1.000E0
 1 10
32 GO:0009898 cytoplasmic side of plasma membrane 9.738E-3 3.682E-2
1.980E-1
1.000E0
 2 169
33 GO:0034703 cation channel complex 1.053E-2 3.725E-2
2.003E-1
1.000E0
 2 176
34 GO:0071437 invadopodium 1.065E-2 3.725E-2
2.003E-1
1.000E0
 1 12
35 GO:0098802 plasma membrane receptor complex 1.099E-2 3.725E-2
2.003E-1
1.000E0
 2 180
36 GO:0098562 cytoplasmic side of membrane 1.146E-2 3.725E-2
2.003E-1
1.000E0
 2 184
37 GO:0005652 nuclear lamina 1.154E-2 3.725E-2
2.003E-1
1.000E0
 1 13
38 GO:0030027 lamellipodium 1.170E-2 3.725E-2
2.003E-1
1.000E0
 2 186
39 GO:0043220 Schmidt-Lanterman incisure 1.330E-2 4.126E-2
2.219E-1
1.000E0
 1 15
40 GO:0043209 myelin sheath 1.369E-2 4.141E-2
2.227E-1
1.000E0
 2 202
41 GO:0043218 compact myelin 1.682E-2 4.963E-2
2.669E-1
1.000E0
 1 19
Show 36 more annotations

4: Human Phenotype [Display Chart] 10 input genes in category / 784 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008497 Congenital craniofacial dysostosis 4.063E-6 3.185E-3 2.307E-2 3.185E-3 2 2
2 HP:0005305 Cerebral venous thrombosis 5.604E-5 1.189E-2
8.612E-2
 4.394E-2 3 38
3 HP:0010940 Aplasia/Hypoplasia of the nasal bone 6.067E-5 1.189E-2
8.612E-2
 4.756E-2 2 6
4 HP:0004646 Hypoplasia of the nasal bone 6.067E-5 1.189E-2
8.612E-2
 4.756E-2 2 6
5 HP:0010939 Abnormality of the nasal bone 1.130E-4 1.476E-2
1.069E-1
8.859E-2
 2 8
6 HP:0008450 Narrow vertebral interpedicular distance 1.130E-4 1.476E-2
1.069E-1
8.859E-2
 2 8
7 HP:0005453 Absent/hypoplastic paranasal sinuses 1.451E-4 1.625E-2
1.177E-1
1.138E-1
 2 9
8 HP:0002297 Red hair 1.812E-4 1.734E-2
1.256E-1
1.420E-1
 2 10
9 HP:0003528 Elevated calcitonin 2.212E-4 1.734E-2
1.256E-1
1.734E-1
 2 11
10 HP:0010937 Abnormality of the nasal skeleton 2.212E-4 1.734E-2
1.256E-1
1.734E-1
 2 11
11 HP:0008438 Vertebral arch anomaly 2.651E-4 1.888E-2
1.367E-1
2.079E-1
 2 12
12 HP:0000852 Pseudohypoparathyroidism 3.130E-4 1.888E-2
1.367E-1
2.454E-1
 2 13
13 HP:0002738 Hypoplastic frontal sinuses 3.130E-4 1.888E-2
1.367E-1
2.454E-1
 2 13
14 HP:0002286 Fair hair 5.432E-4 2.839E-2
2.056E-1
4.259E-1
 2 17
15 HP:0003165 Elevated circulating parathyroid hormone level 5.432E-4 2.839E-2
2.056E-1
4.259E-1
 2 17
16 HP:0003502 Mild short stature 6.815E-4 3.294E-2
2.386E-1
5.343E-1
 2 19
17 HP:0009145 Abnormal cerebral artery morphology 7.152E-4 3.294E-2
2.386E-1
5.608E-1
 4 215
18 HP:0004439 Craniofacial dysostosis 7.564E-4 3.294E-2
2.386E-1
5.930E-1
 2 20
19 HP:0011274 Recurrent mycobacterial infections 9.175E-4 3.747E-2
2.714E-1
7.193E-1
 2 22
20 HP:0008515 Aplasia/Hypoplasia of the vertebrae 1.004E-3 3.747E-2
2.714E-1
7.869E-1
 2 23
21 HP:0008417 Vertebral hypoplasia 1.004E-3 3.747E-2
2.714E-1
7.869E-1
 2 23
22 HP:0003416 Spinal canal stenosis 1.600E-3 4.535E-2
3.284E-1
1.000E0
 2 29
23 HP:0000635 Blue irides 1.600E-3 4.535E-2
3.284E-1
1.000E0
 2 29
24 HP:0100659 Abnormality of the cerebral vasculature 1.795E-3 4.535E-2
3.284E-1
1.000E0
 5 482
25 HP:0100530 Abnormality of calcium-phosphate metabolism 1.828E-3 4.535E-2
3.284E-1
1.000E0
 2 31
26 HP:0010655 Epiphyseal stippling 2.071E-3 4.535E-2
3.284E-1
1.000E0
 2 33
27 HP:0005756 Neonatal epiphyseal stippling 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
28 HP:0030355 Abnormal serum interferon-gamma level 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
29 HP:0011112 Abnormality of serum cytokine level 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
30 HP:0030354 Abnormal serum interferon level 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
31 HP:0045082 Decreased body mass index 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
32 HP:0008225 Thyroid follicular hyperplasia 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
33 HP:0011111 Abnormality of immune serum protein physiology 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
34 HP:0006691 Pulmonic valve myxoma 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
35 HP:0045081 Abnormality of body mass index 2.124E-3 4.535E-2
3.284E-1
1.000E0
 1 1
36 HP:0004418 Thrombophlebitis 2.143E-3 4.535E-2
3.284E-1
1.000E0
 3 130
37 HP:0004936 Venous thrombosis 2.143E-3 4.535E-2
3.284E-1
1.000E0
 3 130
38 HP:0002905 Hyperphosphatemia 2.198E-3 4.535E-2
3.284E-1
1.000E0
 2 34
39 HP:0002832 Calcific stippling 2.463E-3 4.951E-2
3.586E-1
1.000E0
 2 36
Show 34 more annotations

5: Mouse Phenotype [Display Chart] 14 input genes in category / 1186 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003077 abnormal cell cycle 2.509E-6 2.975E-3 2.278E-2 2.975E-3 6 332
2 MP:0020174 abnormal IgG level 8.633E-6 5.119E-3 3.919E-2 1.024E-2 6 411
3 MP:0010639 altered tumor pathology 3.137E-5 9.817E-3
7.516E-2
 3.720E-2 5 299
4 MP:0000858 altered metastatic potential 3.311E-5 9.817E-3
7.516E-2
 3.927E-2 4 145
5 MP:0005070 impaired natural killer cell mediated cytotoxicity 5.810E-5 1.203E-2
9.209E-2
6.891E-2
 3 58
6 MP:0008567 decreased interferon-gamma secretion 6.609E-5 1.203E-2
9.209E-2
7.838E-2
 4 173
7 MP:0011719 abnormal natural killer cell mediated cytotoxicity 7.099E-5 1.203E-2
9.209E-2
8.420E-2
 3 62
8 MP:0011074 abnormal macrophage nitric oxide production 9.272E-5 1.375E-2
1.052E-1
1.100E-1
 2 11
9 MP:0001272 increased metastatic potential 1.885E-4 2.227E-2
1.705E-1
2.235E-1
 3 86
10 MP:0008030 abnormal Cajal-Retzius cell morphology 2.015E-4 2.227E-2
1.705E-1
2.390E-1
 2 16
11 MP:0002406 increased susceptibility to infection 2.167E-4 2.227E-2
1.705E-1
2.571E-1
 5 449
12 MP:0013151 abnormal incidence of induced tumors 2.743E-4 2.227E-2
1.705E-1
3.254E-1
 4 250
13 MP:0008588 abnormal circulating interleukin level 2.828E-4 2.227E-2
1.705E-1
3.354E-1
 4 252
14 MP:0002606 increased basophil cell number 2.865E-4 2.227E-2
1.705E-1
3.398E-1
 2 19
15 MP:0013554 abnormal apocrine gland morphology 3.004E-4 2.227E-2
1.705E-1
3.563E-1
 4 256
16 MP:0000627 abnormal mammary gland morphology 3.004E-4 2.227E-2
1.705E-1
3.563E-1
 4 256
17 MP:0001805 decreased IgG level 3.234E-4 2.240E-2
1.715E-1
3.836E-1
 4 261
18 MP:0010766 abnormal NK cell physiology 3.400E-4 2.240E-2
1.715E-1
4.032E-1
 3 105
19 MP:0008559 abnormal interferon-gamma secretion 4.058E-4 2.533E-2
1.939E-1
4.813E-1
 4 277
20 MP:0008874 decreased physiological sensitivity to xenobiotic 4.643E-4 2.753E-2
2.108E-1
5.507E-1
 4 287
21 MP:0001852 conjunctivitis 5.003E-4 2.793E-2
2.138E-1
5.933E-1
 2 25
22 MP:0008751 abnormal interleukin level 5.220E-4 2.793E-2
2.138E-1
6.191E-1
 4 296
23 MP:0010963 abnormal compact bone volume 5.416E-4 2.793E-2
2.138E-1
6.423E-1
 2 26
24 MP:0004499 increased incidence of tumors by chemical induction 6.360E-4 3.078E-2
2.357E-1
7.543E-1
 3 130
25 MP:0001243 abnormal dermal layer morphology 6.650E-4 3.078E-2
2.357E-1
7.887E-1
 3 132
26 MP:0002418 increased susceptibility to viral infection 6.798E-4 3.078E-2
2.357E-1
8.063E-1
 3 133
27 MP:0008555 abnormal interferon secretion 7.008E-4 3.078E-2
2.357E-1
8.312E-1
 4 320
28 MP:0001212 skin lesions 7.570E-4 3.139E-2
2.403E-1
8.978E-1
 3 138
29 MP:0006410 abnormal common myeloid progenitor cell morphology 7.894E-4 3.139E-2
2.403E-1
9.362E-1
 3 140
30 MP:0008039 increased NK T cell number 8.227E-4 3.139E-2
2.403E-1
9.757E-1
 2 32
31 MP:0010210 abnormal circulating cytokine level 8.233E-4 3.139E-2
2.403E-1
9.764E-1
 4 334
32 MP:0008558 abnormal interferon-beta secretion 8.751E-4 3.139E-2
2.403E-1
1.000E0
 2 33
33 MP:0000792 abnormal cortical marginal zone morphology 8.751E-4 3.139E-2
2.403E-1
1.000E0
 2 33
34 MP:0002460 decreased immunoglobulin level 8.998E-4 3.139E-2
2.403E-1
1.000E0
 4 342
35 MP:0020154 impaired humoral immune response 9.846E-4 3.274E-2
2.507E-1
1.000E0
 2 35
36 MP:0000414 alopecia 1.022E-3 3.274E-2
2.507E-1
1.000E0
 3 153
37 MP:0004947 skin inflammation 1.022E-3 3.274E-2
2.507E-1
1.000E0
 3 153
38 MP:0020176 abnormal IgG2a level 1.163E-3 3.511E-2
2.688E-1
1.000E0
 3 160
39 MP:0002021 increased incidence of induced tumors 1.293E-3 3.511E-2
2.688E-1
1.000E0
 3 166
40 MP:0010293 increased integument system tumor incidence 1.316E-3 3.511E-2
2.688E-1
1.000E0
 3 167
41 MP:0003957 abnormal nitric oxide homeostasis 1.351E-3 3.511E-2
2.688E-1
1.000E0
 2 41
42 MP:0000479 abnormal enterocyte morphology 1.351E-3 3.511E-2
2.688E-1
1.000E0
 2 41
43 MP:0005516 increased liver regeneration 1.352E-3 3.511E-2
2.688E-1
1.000E0
 1 1
44 MP:0013579 increased adrenal gland apoptosis 1.352E-3 3.511E-2
2.688E-1
1.000E0
 1 1
45 MP:0001911 abnormal cerebrospinal fluid production 1.352E-3 3.511E-2
2.688E-1
1.000E0
 1 1
46 MP:0000934 abnormal telencephalon development 1.362E-3 3.511E-2
2.688E-1
1.000E0
 3 169
47 MP:0005463 abnormal CD4-positive, alpha-beta T cell physiology 1.433E-3 3.615E-2
2.768E-1
1.000E0
 3 172
48 MP:0003667 increased hemangiosarcoma incidence 1.555E-3 3.708E-2
2.839E-1
1.000E0
 2 44
49 MP:0001849 ear inflammation 1.555E-3 3.708E-2
2.839E-1
1.000E0
 2 44
50 MP:0004720 abnormal platelet morphology 1.583E-3 3.708E-2
2.839E-1
1.000E0
 4 398
Show 45 more annotations

6: Domain [Display Chart] 17 input genes in category / 193 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR016251 Tyr kinase non-rcpt Jak/Tyk2 InterPro 4.645E-6 3.832E-4 2.239E-3 8.965E-4 2 4
2 IPR014836 Integrin bsu cyt dom InterPro 1.160E-5 3.832E-4 2.239E-3 2.239E-3 2 6
3 PF08725 Integrin b cyt Pfam 1.160E-5 3.832E-4 2.239E-3 2.239E-3 2 6
4 SM01241 Integrin b cyt SMART 1.160E-5 3.832E-4 2.239E-3 2.239E-3 2 6
5 IPR012896 Integrin bsu tail InterPro 1.623E-5 3.832E-4 2.239E-3 3.133E-3 2 7
6 PF07965 Integrin B tail Pfam 1.623E-5 3.832E-4 2.239E-3 3.133E-3 2 7
7 SM01242 Integrin B tail SMART 1.623E-5 3.832E-4 2.239E-3 3.133E-3 2 7
8 IPR002369 Integrin bsu VWA InterPro 2.163E-5 3.832E-4 2.239E-3 4.175E-3 2 8
9 PF00362 Integrin beta Pfam 2.163E-5 3.832E-4 2.239E-3 4.175E-3 2 8
10 SM00187 INB SMART 2.163E-5 3.832E-4 2.239E-3 4.175E-3 2 8
11 PS00243 INTEGRIN BETA PROSITE 2.779E-5 3.832E-4 2.239E-3 5.364E-3 2 9
12 PF17205 PSI integrin Pfam 2.779E-5 3.832E-4 2.239E-3 5.364E-3 2 9
13 IPR033760 Integin beta N InterPro 2.779E-5 3.832E-4 2.239E-3 5.364E-3 2 9
14 IPR015812 Integrin bsu InterPro 2.779E-5 3.832E-4 2.239E-3 5.364E-3 2 9
15 SM00252 SH2 SMART 1.261E-4 1.351E-3 7.896E-3 2.434E-2 3 110
16 PS50001 SH2 PROSITE 1.296E-4 1.351E-3 7.896E-3 2.500E-2 3 111
17 IPR023088 PDEase InterPro 1.313E-4 1.351E-3 7.896E-3 2.535E-2 2 19
18 IPR000980 SH2 InterPro 1.330E-4 1.351E-3 7.896E-3 2.568E-2 3 112
19 3.30.505.10 - Gene3D 1.330E-4 1.351E-3 7.896E-3 2.568E-2 3 112
20 IPR023174 PDEase CS InterPro 1.611E-4 1.413E-3 8.257E-3 3.109E-2 2 21
21 PF00233 PDEase I Pfam 1.611E-4 1.413E-3 8.257E-3 3.109E-2 2 21
22 PS00126 PDEASE I PROSITE 1.611E-4 1.413E-3 8.257E-3 3.109E-2 2 21
23 1.10.1300.10 - Gene3D 1.771E-4 1.486E-3 8.683E-3 3.418E-2 2 22
24 IPR002073 PDEase catalytic dom InterPro 1.939E-4 1.559E-3 9.109E-3 3.742E-2 2 23
25 IPR003607 HD/PDEase dom InterPro 2.114E-4 1.569E-3 9.168E-3 4.080E-2 2 24
26 SM00471 HDc SMART 2.114E-4 1.569E-3 9.168E-3 4.080E-2 2 24
27 IPR032695 Integrin dom InterPro 2.297E-4 1.642E-3 9.591E-3 4.432E-2 2 25
28 IPR016201 PSI InterPro 7.169E-4 3.800E-3 2.220E-2
1.384E-1
 2 44
29 SM00423 PSI SMART 7.835E-4 3.800E-3 2.220E-2
1.512E-1
 2 46
30 IPR000299 FERM domain InterPro 8.888E-4 3.800E-3 2.220E-2
1.715E-1
 2 49
31 IPR019748 FERM central InterPro 8.888E-4 3.800E-3 2.220E-2
1.715E-1
 2 49
32 IPR015439 Integrin bsu-2 InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
33 IPR016045 Tyr kinase non-rcpt TYK2 N InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
34 IPR030298 OTUB1 InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
35 IPR020776 Tyr kinase non-rcpt Jak1 InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
36 IPR022752 STAT1 TAZ2-bd C InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
37 PF01912 eIF-6 Pfam 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
38 PF12162 STAT1 TAZ2bind Pfam 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
39 IPR032646 Tp73 InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
40 SM00654 eIF6 SMART 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
41 IPR027071 Integrin beta-1 InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
42 IPR002769 eIF6 InterPro 9.074E-4 3.800E-3 2.220E-2
1.751E-1
 1 1
43 PS00660 FERM 1 PROSITE 9.253E-4 3.800E-3 2.220E-2
1.786E-1
 2 50
44 IPR019749 Band 41 domain InterPro 9.253E-4 3.800E-3 2.220E-2
1.786E-1
 2 50
45 PS00661 FERM 2 PROSITE 9.253E-4 3.800E-3 2.220E-2
1.786E-1
 2 50
46 SM00295 B41 SMART 9.253E-4 3.800E-3 2.220E-2
1.786E-1
 2 50
47 PS50057 FERM 3 PROSITE 9.253E-4 3.800E-3 2.220E-2
1.786E-1
 2 50
48 IPR008967 p53-like TF DNA-bd InterPro 1.039E-3 4.179E-3 2.441E-2
2.006E-1
 2 53
49 PF07974 EGF 2 Pfam 1.330E-3 5.133E-3 2.999E-2
2.567E-1
 2 60
50 IPR013111 EGF extracell InterPro 1.330E-3 5.133E-3 2.999E-2
2.567E-1
 2 60
Show 45 more annotations

7: Pathway [Display Chart] 16 input genes in category / 530 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 144181 Leishmaniasis BioSystems: KEGG 2.505E-8 7.085E-6 4.854E-5 1.328E-5 5 73
2 1269313 Regulation of IFNA signaling BioSystems: REACTOME 2.674E-8 7.085E-6 4.854E-5 1.417E-5 4 26
3 M19336 Type I Interferon (alpha/beta IFN) Pathway MSigDB C2 BIOCARTA (v6.0) 1.456E-7 2.572E-5 1.762E-4 7.717E-5 3 9
4 1470923 Interleukin-4 and 13 signaling BioSystems: REACTOME 2.375E-7 3.027E-5 2.074E-4 1.259E-4 5 114
5 1269325 Interleukin-6 signaling BioSystems: REACTOME 2.856E-7 3.027E-5 2.074E-4 1.513E-4 3 11
6 213306 Measles BioSystems: KEGG 5.323E-7 4.702E-5 3.221E-4 2.821E-4 5 134
7 M8066 IL22 Soluble Receptor Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.654E-7 7.309E-5 5.008E-4 5.117E-4 3 16
8 1269312 Interferon alpha/beta signaling BioSystems: REACTOME 1.495E-6 9.119E-5 6.247E-4 7.926E-4 4 69
9 PW:0000368 Non-STAT, JAK dependent Pathway Ontology 1.548E-6 9.119E-5 6.247E-4 8.207E-4 2 2
10 217173 Influenza A BioSystems: KEGG 1.887E-6 1.000E-4 6.851E-4 1.000E-3 5 173
11 137929 IL27-mediated signaling events BioSystems: Pathway Interaction Database 4.447E-6 2.038E-4 1.396E-3 2.357E-3 3 26
12 1339142 Interleukin-6 family signaling BioSystems: REACTOME 4.999E-6 2.038E-4 1.396E-3 2.650E-3 3 27
13 1269591 DARPP-32 events BioSystems: REACTOME 4.999E-6 2.038E-4 1.396E-3 2.650E-3 3 27
14 PW:0000209 JAK-STAT signaling Pathway Ontology 6.235E-6 2.360E-4 1.617E-3 3.305E-3 3 29
15 M1909 EGF Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 7.658E-6 2.706E-4 1.854E-3 4.059E-3 3 31
16 M2529 PDGF Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 8.444E-6 2.797E-4 1.916E-3 4.475E-3 3 32
17 169642 Toxoplasmosis BioSystems: KEGG 1.077E-5 3.356E-4 2.299E-3 5.706E-3 4 113
18 169350 Signaling events mediated by TCPTP BioSystems: Pathway Interaction Database 1.212E-5 3.568E-4 2.444E-3 6.422E-3 3 36
19 193147 Osteoclast differentiation BioSystems: KEGG 1.874E-5 5.119E-4 3.507E-3 9.934E-3 4 130
20 173973 Hepatitis C BioSystems: KEGG 1.932E-5 5.119E-4 3.507E-3 1.024E-2 4 131
21 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 2.083E-5 5.257E-4 3.601E-3 1.104E-2 3 43
22 PW:0000543 protein kinase A (PKA) signaling Pathway Ontology 2.728E-5 6.461E-4 4.427E-3 1.446E-2 3 47
23 694606 Hepatitis B BioSystems: KEGG 2.804E-5 6.461E-4 4.427E-3 1.486E-2 4 144
24 M17580 Interleukin 13 (IL-13) Pathway MSigDB C2 BIOCARTA (v6.0) 3.240E-5 7.154E-4 4.901E-3 1.717E-2 2 7
25 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 3.704E-5 7.825E-4 5.361E-3 1.963E-2 3 52
26 83077 Jak-STAT signaling pathway BioSystems: KEGG 3.839E-5 7.825E-4 5.361E-3 2.035E-2 4 156
27 122191 NOD-like receptor signaling pathway BioSystems: KEGG 5.373E-5 1.050E-3 7.191E-3 2.847E-2 4 170
28 1269505 MAPK1 (ERK2) activation BioSystems: REACTOME 5.545E-5 1.050E-3 7.191E-3 2.939E-2 2 9
29 1269504 MAPK3 (ERK1) activation BioSystems: REACTOME 6.927E-5 1.224E-3 8.383E-3 3.671E-2 2 10
30 M4170 Interferon gamma pathway. MSigDB C2 BIOCARTA (v6.0) 6.927E-5 1.224E-3 8.383E-3 3.671E-2 2 10
31 377873 Herpes simplex infection BioSystems: KEGG 7.469E-5 1.277E-3 8.749E-3 3.959E-2 4 185
32 M4956 Monocyte and its Surface Molecules MSigDB C2 BIOCARTA (v6.0) 8.459E-5 1.359E-3 9.308E-3 4.483E-2 2 11
33 M1469 Adhesion and Diapedesis of Lymphocytes MSigDB C2 BIOCARTA (v6.0) 8.459E-5 1.359E-3 9.308E-3 4.483E-2 2 11
34 83105 Pathways in cancer BioSystems: KEGG 1.025E-4 1.591E-3 1.090E-2
5.433E-2
 5 395
35 1269311 Interferon Signaling BioSystems: REACTOME 1.051E-4 1.591E-3 1.090E-2
5.568E-2
 4 202
36 M19829 Attenuation of GPCR Signaling MSigDB C2 BIOCARTA (v6.0) 1.198E-4 1.749E-3 1.198E-2
6.349E-2
 2 13
37 868086 Rap1 signaling pathway BioSystems: KEGG 1.221E-4 1.749E-3 1.198E-2
6.471E-2
 4 210
38 1269315 Regulation of IFNG signaling BioSystems: REACTOME 1.396E-4 1.948E-3 1.334E-2
7.401E-2
 2 14
39 1269584 Opioid Signalling BioSystems: REACTOME 1.613E-4 2.192E-3 1.502E-2
8.549E-2
 3 85
40 P00038 JAK/STAT signaling pathway PantherDB 1.839E-4 2.436E-3 1.669E-2
9.746E-2
 2 16
41 552665 Morphine addiction BioSystems: KEGG 1.975E-4 2.508E-3 1.718E-2
1.047E-1
 3 91
42 1458885 Th1 and Th2 cell differentiation BioSystems: KEGG 2.040E-4 2.508E-3 1.718E-2
1.081E-1
 3 92
43 M3952 Cells and Molecules involved in local acute inflammatory response MSigDB C2 BIOCARTA (v6.0) 2.082E-4 2.508E-3 1.718E-2
1.104E-1
 2 17
44 M6778 IL-10 Anti-inflammatory Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 2.082E-4 2.508E-3 1.718E-2
1.104E-1
 2 17
45 138021 Paxillin-dependent events mediated by a4b1 BioSystems: Pathway Interaction Database 2.614E-4 3.079E-3 2.110E-2
1.386E-1
 2 19
46 1339143 IL-6-type cytokine receptor ligand interactions BioSystems: REACTOME 2.903E-4 3.344E-3 2.291E-2
1.538E-1
 2 20
47 1469482 Th17 cell differentiation BioSystems: KEGG 3.186E-4 3.593E-3 2.461E-2
1.689E-1
 3 107
48 M8731 Aspirin Blocks Signaling Pathway Involved in Platelet Activation MSigDB C2 BIOCARTA (v6.0) 3.524E-4 3.662E-3 2.509E-2
1.868E-1
 2 22
49 M5489 IL 6 signaling pathway MSigDB C2 BIOCARTA (v6.0) 3.524E-4 3.662E-3 2.509E-2
1.868E-1
 2 22
50 M3873 Apoptotic Signaling in Response to DNA Damage MSigDB C2 BIOCARTA (v6.0) 3.524E-4 3.662E-3 2.509E-2
1.868E-1
 2 22
Show 45 more annotations

8: Pubmed [Display Chart] 17 input genes in category / 7221 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20065083 A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α. Pubmed 3.378E-12 2.032E-8 1.923E-7 2.439E-8 4 9
2 12960323 The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex. Pubmed 5.629E-12 2.032E-8 1.923E-7 4.065E-8 4 10
3 19434718 Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Pubmed 1.915E-11 4.609E-8 4.361E-7 1.383E-7 4 13
4 8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Pubmed 7.324E-11 1.322E-7 1.251E-6 5.289E-7 3 3
5 7579387 Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. Pubmed 7.320E-10 1.057E-6 1.000E-5 5.286E-6 3 5
6 10954736 A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Pubmed 2.561E-9 3.082E-6 2.916E-5 1.849E-5 3 7
7 7657660 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. Pubmed 4.096E-9 4.225E-6 3.998E-5 2.958E-5 3 8
8 12817007 Activation of protein kinase C delta by IFN-gamma. Pubmed 6.142E-9 4.928E-6 4.663E-5 4.435E-5 3 9
9 9484840 Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains. Pubmed 6.142E-9 4.928E-6 4.663E-5 4.435E-5 3 9
10 16751369 Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. Pubmed 8.772E-9 5.758E-6 5.449E-5 6.334E-5 3 10
11 7690989 A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Pubmed 8.772E-9 5.758E-6 5.449E-5 6.334E-5 3 10
12 15322115 Protein kinase Cdelta regulates apoptosis via activation of STAT1. Pubmed 1.206E-8 6.698E-6 6.337E-5 8.707E-5 3 11
13 7543024 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Pubmed 1.206E-8 6.698E-6 6.337E-5 8.707E-5 3 11
14 10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Pubmed 1.607E-8 7.737E-6 7.321E-5 1.161E-4 3 12
15 12637327 Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells. Pubmed 1.607E-8 7.737E-6 7.321E-5 1.161E-4 3 12
16 7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Pubmed 2.089E-8 9.427E-6 8.920E-5 1.508E-4 3 13
17 20503287 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Pubmed 2.431E-8 9.938E-6 9.403E-5 1.755E-4 5 204
18 19258923 Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pubmed 2.491E-8 9.938E-6 9.403E-5 1.799E-4 5 205
19 17703412 Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Pubmed 2.615E-8 9.938E-6 9.403E-5 1.888E-4 5 207
20 11839738 Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. Pubmed 3.321E-8 1.199E-5 1.135E-4 2.398E-4 3 15
21 20588308 Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Pubmed 7.008E-8 2.410E-5 2.280E-4 5.060E-4 4 91
22 11694501 TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. Pubmed 8.310E-8 2.728E-5 2.581E-4 6.001E-4 3 20
23 19730683 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Pubmed 9.849E-8 2.927E-5 2.770E-4 7.112E-4 4 99
24 11294897 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Pubmed 1.674E-7 2.927E-5 2.770E-4 1.209E-3 3 25
25 11914080 The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
26 23043190 PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
27 17088426 PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
28 14617019 Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
29 1386289 A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
30 16239216 JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
31 17719638 The context of HLA-DR/CD18 complex in the plasma membrane governs HLA-DR-derived signals in activated monocytes. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
32 8702790 Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
33 8608597 Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
34 21949722 Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
35 26763073 Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
36 17686504 Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signaling. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
37 7589562 Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
38 12183834 Decreased stroma adhesion capacity of CD34+ progenitor cells from mobilized peripheral blood is not lineage- or stage-specific and is associated with low beta 1 and beta 2 integrin expression. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
39 16000408 Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
40 23703473 Aspirin enhances IFN-α-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
41 16415171 Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
42 11931654 beta1 and beta2 integrins activate different signalling pathways in monocytes. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
43 7490523 Cytokine receptor signalling through two novel families of transducer molecules: Janus kinases, and signal transducers and activators of transcription. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
44 15003452 Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
45 10982844 Regulation of STAT1 nuclear export by Jak1. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
46 21665150 Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. Pubmed 1.865E-7 2.927E-5 2.770E-4 1.347E-3 2 2
47 26193702 Type III Interferon Induces Distinct SOCS1 Expression Pattern that Contributes to Delayed but Prolonged Activation of Jak/STAT Signaling Pathway: Implications for Treatment Non-Response in HCV Patients. Pubmed 5.593E-7 4.986E-5 4.718E-4 4.038E-3 2 3
48 25156366 Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. Pubmed 5.593E-7 4.986E-5 4.718E-4 4.038E-3 2 3
49 20183869 Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain. Pubmed 5.593E-7 4.986E-5 4.718E-4 4.038E-3 2 3
50 10388537 Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction. Pubmed 5.593E-7 4.986E-5 4.718E-4 4.038E-3 2 3
Show 45 more annotations

9: Interaction [Display Chart] 17 input genes in category / 1200 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RACK1 RACK1 interactions 1.178E-23 1.414E-20 1.084E-19 1.414E-20 14 263
2 int:IFNAR2 IFNAR2 interactions 3.634E-12 2.181E-9 1.672E-8 4.361E-9 5 18
3 int:STAT2 STAT2 interactions 1.787E-7 7.146E-5 5.479E-4 2.144E-4 4 54
4 int:TYK2 TYK2 interactions 2.427E-6 7.053E-4 5.408E-3 2.912E-3 4 103
5 int:CSF2RB CSF2RB interactions 2.939E-6 7.053E-4 5.408E-3 3.526E-3 3 30
6 int:PLAUR PLAUR interactions 3.768E-6 7.151E-4 5.483E-3 4.521E-3 4 115
7 int:PRKCB PRKCB interactions 4.767E-6 7.151E-4 5.483E-3 5.720E-3 4 122
8 int:JAK1 JAK1 interactions 4.767E-6 7.151E-4 5.483E-3 5.720E-3 4 122
9 int:ELP2 ELP2 interactions 6.077E-6 8.103E-4 6.213E-3 7.293E-3 3 38
10 int:IL6ST IL6ST interactions 7.666E-6 9.199E-4 7.053E-3 9.199E-3 3 41
11 int:PTK2 PTK2 interactions 1.538E-5 1.598E-3 1.225E-2 1.846E-2 4 164
12 int:YAP1 YAP1 interactions 1.711E-5 1.598E-3 1.225E-2 2.054E-2 5 360
13 int:PRKCD PRKCD interactions 1.731E-5 1.598E-3 1.225E-2 2.078E-2 4 169
14 int:PTPRC PTPRC interactions 2.084E-5 1.786E-3 1.370E-2 2.501E-2 3 57
15 int:NMRK2 NMRK2 interactions 2.422E-5 1.817E-3 1.393E-2 2.906E-2 2 8
16 int:JAKMIP1 JAKMIP1 interactions 2.422E-5 1.817E-3 1.393E-2 2.906E-2 2 8
17 int:EIF2AK2 EIF2AK2 interactions 2.858E-5 2.017E-3 1.547E-2 3.429E-2 4 192
18 int:STAT1 STAT1 interactions 3.908E-5 2.606E-3 1.998E-2 4.690E-2 4 208
19 int:ICAM4 ICAM4 interactions 5.696E-5 3.598E-3 2.759E-2
6.836E-2
 2 12
20 int:PRKCE PRKCE interactions 7.417E-5 4.279E-3 3.281E-2
8.900E-2
 3 87
21 int:SOCS5 SOCS5 interactions 7.845E-5 4.279E-3 3.281E-2
9.414E-2
 2 14
22 int:CABLES1 CABLES1 interactions 7.845E-5 4.279E-3 3.281E-2
9.414E-2
 2 14
23 int:PDE4B PDE4B interactions 9.047E-5 4.720E-3 3.619E-2
1.086E-1
 2 15
24 int:PRKACA PRKACA interactions 1.291E-4 6.456E-3 4.950E-2
1.549E-1
 4 283
25 int:PDGFRB PDGFRB interactions 1.530E-4 7.345E-3
5.632E-2
1.836E-1
 3 111
26 int:STAT3 STAT3 interactions 1.658E-4 7.652E-3
5.868E-2
1.990E-1
 4 302
27 int:SMAD2 SMAD2 interactions 1.744E-4 7.751E-3
5.943E-2
2.093E-1
 4 306
28 int:SYK SYK interactions 2.909E-4 1.240E-2
9.505E-2
3.491E-1
 3 138
29 int:RANBP9 RANBP9 interactions 3.099E-4 1.240E-2
9.505E-2
3.719E-1
 3 141
30 int:CRKL CRKL interactions 3.099E-4 1.240E-2
9.505E-2
3.719E-1
 3 141
31 int:PPP1CA PPP1CA interactions 3.601E-4 1.394E-2
1.069E-1
4.322E-1
 4 370
32 int:IL2RB IL2RB interactions 4.233E-4 1.499E-2
1.149E-1
5.079E-1
 2 32
33 int:IL27RA IL27RA interactions 4.233E-4 1.499E-2
1.149E-1
5.079E-1
 2 32
34 int:ECT2 ECT2 interactions 4.247E-4 1.499E-2
1.149E-1
5.097E-1
 3 157
35 int:IFNGR1 IFNGR1 interactions 4.782E-4 1.594E-2
1.222E-1
5.738E-1
 2 34
36 int:CYTH2 CYTH2 interactions 4.782E-4 1.594E-2
1.222E-1
5.738E-1
 2 34
37 int:NFKBIA NFKBIA interactions 5.176E-4 1.679E-2
1.287E-1
6.212E-1
 3 168
38 int:IL2RG IL2RG interactions 5.364E-4 1.694E-2
1.299E-1
6.437E-1
 2 36
39 int:CCR1 CCR1 interactions 5.667E-4 1.744E-2
1.337E-1
6.801E-1
 2 37
40 int:TNFRSF1A TNFRSF1A interactions 5.928E-4 1.750E-2
1.342E-1
7.114E-1
 3 176
41 int:IRF9 IRF9 interactions 5.979E-4 1.750E-2
1.342E-1
7.175E-1
 2 38
42 int:DTX3L DTX3L interactions 6.299E-4 1.800E-2
1.380E-1
7.558E-1
 2 39
43 int:IFNAR1 IFNAR1 interactions 6.626E-4 1.849E-2
1.418E-1
7.952E-1
 2 40
44 int:AKAP1 AKAP1 interactions 6.962E-4 1.899E-2
1.456E-1
8.355E-1
 2 41
45 int:CD82 CD82 interactions 7.658E-4 2.042E-2
1.566E-1
9.190E-1
 2 43
46 int:CCR5 CCR5 interactions 8.387E-4 2.188E-2
1.678E-1
1.000E0
 2 45
47 int:PDE4D PDE4D interactions 8.763E-4 2.237E-2
1.716E-1
1.000E0
 2 46
48 int:GHR GHR interactions 9.540E-4 2.385E-2
1.829E-1
1.000E0
 2 48
49 int:RNF19B RNF19B interactions 9.940E-4 2.386E-2
1.829E-1
1.000E0
 2 49
50 int:IL4R IL4R interactions 9.940E-4 2.386E-2
1.829E-1
1.000E0
 2 49
Show 45 more annotations

10: Cytoband [Display Chart] 17 input genes in category / 17 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 13q12.3-q13 13q12.3-q13 4.905E-4 8.334E-3 2.867E-2 8.338E-3 1 1
2 1p32.3-p31.3 1p32.3-p31.3 9.807E-4 8.334E-3 2.867E-2 1.667E-2 1 2
3 17q23-q24 17q23-q24 1.471E-3 8.334E-3 2.867E-2 2.500E-2 1 3
4 5q12 5q12 2.939E-3 1.248E-2 4.294E-2 4.997E-2 1 6
5 10p11.2 10p11.2 3.917E-3 1.248E-2 4.294E-2
6.660E-2
 1 8
6 18p11.2 18p11.2 4.406E-3 1.248E-2 4.294E-2
7.490E-2
 1 9
7 7q31.2 7q31.2 5.871E-3 1.385E-2 4.764E-2
9.980E-2
 1 12
8 1p36.3 1p36.3 6.846E-3 1.385E-2 4.764E-2
1.164E-1
 1 14
9 2q32.2 2q32.2 7.333E-3 1.385E-2 4.764E-2
1.247E-1
 1 15
10 10p11.21 10p11.21 9.280E-3 1.578E-2
5.426E-2
1.578E-1
 1 19
11 1p31 1p31 1.171E-2 1.796E-2
6.178E-2
1.991E-1
 1 24
12 20q12 20q12 1.268E-2 1.796E-2
6.178E-2
2.155E-1
 1 26
13 21q22.11 21q22.11 3.094E-2 3.930E-2
1.352E-1
5.259E-1
 1 64
14 11q13.1 11q13.1 3.237E-2 3.930E-2
1.352E-1
5.502E-1
 1 67
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 89 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 13 input genes in category / 16 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1159 Integrin beta subunits genenames.org 1.692E-5 2.707E-4 9.152E-4 2.707E-4 2 9
2 681 Phosphodiesterases genenames.org 1.289E-4 1.031E-3 3.487E-3 2.063E-3 2 24
3 1293 Minor histocompatibility antigens|FERM domain containing genenames.org 5.663E-4 3.020E-3 1.021E-2 9.060E-3 2 50
4 599 CD molecules|Interferon receptors genenames.org 3.568E-3 1.427E-2 4.825E-2
5.709E-2
 1 5
5 835 C2 domain containing protein kinases genenames.org 7.124E-3 2.280E-2
7.707E-2
1.140E-1
 1 10
6 669 OTU domain containing genenames.org 1.208E-2 3.222E-2
1.089E-1
1.933E-1
 1 17
7 813 Fibronectin type III domain containing|Protein tyrosine phosphatases, receptor type genenames.org 1.491E-2 3.407E-2
1.152E-1
2.385E-1
 1 21
8 473 Cyclins genenames.org 2.053E-2 4.106E-2
1.388E-1
3.285E-1
 1 29
9 492 Complement system|Sushi domain containing genenames.org 2.543E-2 4.521E-2
1.528E-1
4.068E-1
 1 36
10 471 CD molecules|Tumor necrosis factor superfamily genenames.org 3.116E-2 4.986E-2
1.686E-1
4.986E-1
 2 394
Show 5 more annotations

13: Coexpression [Display Chart] 17 input genes in category / 2508 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15626 Genes up-regulated during prostate cancer progression in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.727E-7 5.494E-4 4.618E-3 9.347E-4 3 20
2 M11234 Genes down-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.680E-7 5.494E-4 4.618E-3 1.174E-3 5 225
3 17571080-SuppTable2b Human Leukemia Sun07 283genes GeneSigDB 6.572E-7 5.494E-4 4.618E-3 1.648E-3 5 241
4 M11685 Top 50 down-regulated markers for the diffused large B-cell lymphoma (DLBCL) that distinguished between cured and fatal/refractory clinical outcomes. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.587E-6 2.575E-3 2.164E-2 1.150E-2 3 45
5 M8129 Genes down-regulated in AGS cells (gastric adenocarcinoma): control versus H. pylori LPS. MSigDB C7: Immunologic Signatures (v6.0) 5.134E-6 2.575E-3 2.164E-2 1.288E-2 4 162
6 20036005-Table3 Human Leukemia Tavolaro10 56genes GeneSigDB 7.121E-6 2.961E-3 2.489E-2 1.786E-2 3 52
7 M5295 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 1.158E-5 2.961E-3 2.489E-2 2.903E-2 4 199
8 M5046 Genes up-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-acute infection versus splenic primary CD8 effector T cells at day 8 post-chronic infection. MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 2.961E-3 2.489E-2 2.961E-2 4 200
9 M3440 Genes down-regulated in comparison of intrathymic T progenitor cells (ITTP) versus CD4 [GeneID=920] thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 2.961E-3 2.489E-2 2.961E-2 4 200
10 M5950 Genes up-regulated during transplant rejection. MSigDB H: Hallmark Gene Sets (v6.0) 1.181E-5 2.961E-3 2.489E-2 2.961E-2 4 200
11 18381418-Table1 Mouse Prostate Ouyang08 121genes GeneSigDB 3.135E-5 7.025E-3
5.904E-2
7.863E-2
 3 85
12 M19695 Genes up-regulated in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.361E-5 7.025E-3
5.904E-2
8.430E-2
 3 87
13 16269079-TableS4 Human StemCell Cui05 113genes GeneSigDB 6.065E-5 1.170E-2
9.835E-2
1.521E-1
 3 106
14 20460173-ImmPortNaturalKillerCellCytotoxicity Human Immune Kong10 135genes ImmPort NaturalKillerCellCytotoxicity GeneSigDB 1.014E-4 1.711E-2
1.438E-1
2.543E-1
 3 126
15 19014521-TableS6b Human Breast Reyal08 159genes GeneSigDB 1.836E-4 1.711E-2
1.438E-1
4.605E-1
 3 154
16 19755675-TableS6 Human Leukemia Li09 419genes GeneSigDB 1.926E-4 1.711E-2
1.438E-1
4.830E-1
 4 410
17 M15047 The 'NPM1 signature 3': genes down-regulated in pediatric AML (acute myeloid leukemia) with mutated NPM1 [GeneID=4869] compared to the AML cases with intact NPM1 and MLL [GeneID=4297]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.132E-4 1.711E-2
1.438E-1
5.347E-1
 3 162
18 M6329 Genes up-regulated in untreated spleen: DUSP1 [GeneID=1843] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 2.132E-4 1.711E-2
1.438E-1
5.347E-1
 3 162
19 M3732 Genes down-regulated in response to UVB radiation in HFK cells (keratinocytes) immortalized by overexpression of HPV E6 and E7 viral oncogenes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.333E-4 1.711E-2
1.438E-1
5.852E-1
 2 31
20 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.394E-4 1.711E-2
1.438E-1
6.004E-1
 4 434
21 15471956-Table2 Human Leukemia Sasaki05 192genes GeneSigDB 2.414E-4 1.711E-2
1.438E-1
6.055E-1
 3 169
22 M15588 Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 16 days after transduction. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.675E-4 1.711E-2
1.438E-1
6.709E-1
 3 175
23 M6703 Genes down-regulated in endothelial cells: interferon beta versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.675E-4 1.711E-2
1.438E-1
6.709E-1
 3 175
24 M7637 Genes down-regulated in memory CD8 T cells: 3' versus 4'. MSigDB C7: Immunologic Signatures (v6.0) 2.720E-4 1.711E-2
1.438E-1
6.823E-1
 3 176
25 M15171 Genes up-regulated in adult T-cell leukemia (ATL) cells compared to T lymphocytes from healthy controls. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.720E-4 1.711E-2
1.438E-1
6.823E-1
 3 176
26 M6323 Genes up-regulated in spleen from DUSP1 [GeneID=1843] knockout: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.720E-4 1.711E-2
1.438E-1
6.823E-1
 3 176
27 M8898 Genes down-regulated in CD4 [GeneID=920] versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.812E-4 1.711E-2
1.438E-1
7.053E-1
 3 178
28 17213807-Table1 Human StemCell Shi07 38genes GeneSigDB 2.981E-4 1.711E-2
1.438E-1
7.475E-1
 2 35
29 M377 Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v6.0) 3.099E-4 1.711E-2
1.438E-1
7.773E-1
 3 184
30 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 3.217E-4 1.711E-2
1.438E-1
8.068E-1
 4 469
31 18544678-Table1 Human Lymphoma Rimsza08 37genes GeneSigDB 3.333E-4 1.711E-2
1.438E-1
8.360E-1
 2 37
32 M2816 Genes up-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 3.511E-4 1.711E-2
1.438E-1
8.806E-1
 3 192
33 15479729-Table1 Human Lymphoma Guedez05 40genes GeneSigDB 3.517E-4 1.711E-2
1.438E-1
8.821E-1
 2 38
34 M4296 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 18 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h. MSigDB C7: Immunologic Signatures (v6.0) 3.730E-4 1.711E-2
1.438E-1
9.354E-1
 3 196
35 M4174 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 3.842E-4 1.711E-2
1.438E-1
9.636E-1
 3 198
36 M4189 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 3.842E-4 1.711E-2
1.438E-1
9.636E-1
 3 198
37 M5490 Up-regulated by induction of exogenous BRCA1 in EcR-293 cells MSigDB C2: CGP Curated Gene Sets (v6.0) 3.842E-4 1.711E-2
1.438E-1
9.636E-1
 3 198
38 M4187 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 3.842E-4 1.711E-2
1.438E-1
9.636E-1
 3 198
39 M5960 Genes up-regulated in livers: SOCS3 [GeneID=9021] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 3.899E-4 1.711E-2
1.438E-1
9.779E-1
 3 199
40 M9322 Genes up-regulated in marginal zone B cells versus day 7 plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 3.899E-4 1.711E-2
1.438E-1
9.779E-1
 3 199
41 M3454 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
42 M4075 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
43 M5530 Genes up-regulated in comparison of neutrophils versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
44 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
45 M7177 Genes down-regulated in B lymphocytes from cord blood: naïve versus transitional CR2 [GeneID=1380]. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
46 M5368 Genes down-regulated in comparison of untreated macrophages versus macrophages treated with LPS (TLR4 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
47 M9313 Genes up-regulated in follicular B cells versus day 40 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
48 M7174 Genes down-regulated in transitional B lymphocytes: CR2 [GeneID=1380] low versus CR2 [GeneID=1380] high. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
49 M6062 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (6h) versus IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
50 M4349 Genes up-regulated in comparison of lung tissue from wild type mice versus that from TLR4 [GeneID=7099] deficient animals. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.711E-2
1.438E-1
9.923E-1
 3 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 17 input genes in category / 1482 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingKidney e15.5 Endothelial cells 1000 k1 DevelopingKidney e15.5 Endothelial cells emap-29965 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.691E-6 3.122E-3 2.460E-2 3.987E-3 5 303
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/mature natural killer cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/mature natural killer cell Tabula Muris Consortium 7.807E-6 3.122E-3 2.460E-2 1.157E-2 4 170
3 GSM538297 500 NK cells, NK.DAP12-.Sp, NK1.1+ CD3-, Spleen, avg-3 Immgen.org, GSE15907 1.065E-5 3.122E-3 2.460E-2 1.579E-2 5 402
4 GSM605814 500 NK cells, NK.49H+.Sp, NK1.1+ Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 1.078E-5 3.122E-3 2.460E-2 1.598E-2 5 403
5 GSM605817 500 NK cells, NK.49H-.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 1.214E-5 3.122E-3 2.460E-2 1.799E-2 5 413
6 Lung Development Lungmap - Mouse FluidigmC1 Immune Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Immune Overall Top 500 Genes 1.286E-5 3.122E-3 2.460E-2 1.906E-2 5 418
7 DevelopingKidney e15.5 Endothelial cells emap-29977 k5 1000 DevelopingKidney e15.5 Endothelial cells emap-29977 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.475E-5 3.122E-3 2.460E-2 2.186E-2 5 430
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Pelvis Wilms Renal cell carcinoma/Kidney Normal-Pelvis Wilms T12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Pelvis Wilms Renal cell carcinoma/Kidney Normal-Pelvis Wilms T12 Adult, Development, and Cancer types 3.106E-5 5.754E-3 4.533E-2 4.603E-2 3 80
9 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/macrophage Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/macrophage Tabula Muris Consortium 3.858E-5 6.352E-3
5.005E-2
5.717E-2
 3 86
10 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/B cell Tabula Muris Consortium 7.002E-5 1.038E-2
8.175E-2
1.038E-1
 3 105
11 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells C PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells C PND01-03 Top 200 Genes 1.399E-4 1.823E-2
1.437E-1
2.074E-1
 4 356
12 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells C Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells C Top 200 Genes 1.476E-4 1.823E-2
1.437E-1
2.188E-1
 4 361
13 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Top 200 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Top 200 1.726E-4 1.962E-2
1.546E-1
2.558E-1
 4 376
14 Sample Type by Project: Shred 1/TCGA-Head and Neck/Head and Neck Carcinoma/Squamous Cell Carcinoma/2/0 Sample Type by Project: Shred 1/TCGA-Head and Neck/Head and Neck Carcinoma/Squamous Cell Carcinoma/2/0 TCGA-Head and Neck 1.937E-4 1.962E-2
1.546E-1
2.870E-1
 3 148
15 GSM538291 500 NK cells, NK.b2m-.Sp, NK1.1+ TCRb-, Spleen, avg-3 Immgen.org, GSE15907 1.986E-4 1.962E-2
1.546E-1
2.943E-1
 4 390
16 GSM538315 500 NK cells, NK.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.382E-4 2.175E-2
1.714E-1
3.530E-1
 4 409
17 GSM538303 500 NK cells, NK.H+.MCMV7.Sp, NK1.1+ TCRb- Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 2.495E-4 2.175E-2
1.714E-1
3.698E-1
 4 414
18 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k2 1000 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.813E-4 2.316E-2
1.824E-1
4.168E-1
 3 168
19 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/macrophage Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/macrophage Tabula Muris Consortium 3.673E-4 2.865E-2
2.257E-1
5.443E-1
 3 184
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC/Kidney Tumour VHL RCC MNP PapRCC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC/Kidney Tumour VHL RCC MNP PapRCC Adult, Development, and Cancer types 4.160E-4 3.082E-2
2.428E-1
6.164E-1
 3 192
21 gudmap kidney adult RenMedVasc Tie2 k3 200 kidney adult RenMedVasc Tie2 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.117E-4 4.926E-2
3.881E-1
1.000E0
 2 51
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Tumour VHL RCC Fetus other/Kidney Tumour VHL RCC F2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Tumour VHL RCC Fetus other/Kidney Tumour VHL RCC F2 Adult, Development, and Cancer types 7.788E-4 4.926E-2
3.881E-1
1.000E0
 1 1
23 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Biphasic/3/1 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Biphasic/3/1 TCGA-Mesothelium 7.788E-4 4.926E-2
3.881E-1
1.000E0
 1 1
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Private/Kidney NephrogenicRest Wilms Private/Kidney NephrogenicRest Wilms IN12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Private/Kidney NephrogenicRest Wilms Private/Kidney NephrogenicRest Wilms IN12 Adult, Development, and Cancer types 7.977E-4 4.926E-2
3.881E-1
1.000E0
 2 54
Show 19 more annotations

15: Computational [Display Chart] 15 input genes in category / 149 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 17 input genes in category / 650 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-7:PITA hsa-miR-7:PITA TOP PITA 2.123E-5 7.652E-3
5.399E-2
 1.380E-2 3 231
2 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 4.349E-5 7.652E-3
5.399E-2
 2.827E-2 3 294
3 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 7.107E-5 7.652E-3
5.399E-2
 4.619E-2 3 347
4 hsa-miR-30d-5p:Functional MTI Functional MTI miRTarbase 8.455E-5 7.652E-3
5.399E-2
5.496E-2
 3 368
5 hsa-miR-1261:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.549E-5 7.652E-3
5.399E-2
5.557E-2
 2 58
6 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 9.588E-5 7.652E-3
5.399E-2
6.232E-2
 3 384
7 hsa-miR-7-5p:TargetScan hsa-miR-7-5p TargetScan 1.122E-4 7.652E-3
5.399E-2
7.292E-2
 3 405
8 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 1.214E-4 7.652E-3
5.399E-2
7.891E-2
 3 416
9 hsa-miR-6126:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.247E-4 7.652E-3
5.399E-2
8.105E-2
 2 70
10 hsa-miR-1279:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.470E-4 7.652E-3
5.399E-2
9.557E-2
 2 76
11 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.509E-4 7.652E-3
5.399E-2
9.810E-2
 2 77
12 hsa-miR-372-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.643E-4 7.652E-3
5.399E-2
1.068E-1
 3 461
13 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 1.850E-4 7.652E-3
5.399E-2
1.202E-1
 3 480
14 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 1.884E-4 7.652E-3
5.399E-2
1.224E-1
 3 483
15 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 1.884E-4 7.652E-3
5.399E-2
1.224E-1
 3 483
16 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 1.884E-4 7.652E-3
5.399E-2
1.224E-1
 3 483
17 hsa-miR-6730-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.202E-4 8.108E-3
5.720E-2
1.431E-1
 2 93
18 hsa-miR-4735-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.346E-4 8.108E-3
5.720E-2
1.525E-1
 2 96
19 hsa-miR-223-3p:Functional MTI Functional MTI miRTarbase 2.445E-4 8.108E-3
5.720E-2
1.589E-1
 2 98
20 hsa-miR-542-5p:mirSVR highEffct hsa-miR-542-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.495E-4 8.108E-3
5.720E-2
1.622E-1
 2 99
21 hsa-miR-18b-5p:Functional MTI Functional MTI miRTarbase 3.422E-4 1.059E-2
7.473E-2
2.224E-1
 2 116
22 hsa-miR-3910:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.722E-4 1.076E-2
7.588E-2
2.419E-1
 2 121
23 hsa-miR-548at-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.971E-4 1.076E-2
7.588E-2
2.581E-1
 2 125
24 hsa-miR-668-3p:TargetScan hsa-miR-668-3p TargetScan 3.971E-4 1.076E-2
7.588E-2
2.581E-1
 2 125
25 hsa-miR-605-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-4 1.088E-2
7.677E-2
2.964E-1
 2 134
26 TGTATGA,MIR-485-3P:MSigDB TGTATGA,MIR-485-3P:MSigDB MSigDB 4.628E-4 1.088E-2
7.677E-2
3.008E-1
 2 135
27 hsa-miR-525-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-4 1.088E-2
7.677E-2
3.143E-1
 2 138
28 hsa-miR-599:PITA hsa-miR-599:PITA TOP PITA 4.835E-4 1.088E-2
7.677E-2
3.143E-1
 2 138
29 hsa-miR-588:PITA hsa-miR-588:PITA TOP PITA 5.046E-4 1.088E-2
7.677E-2
3.280E-1
 2 141
30 hsa-miR-520a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.046E-4 1.088E-2
7.677E-2
3.280E-1
 2 141
31 hsa-miR-3180-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.190E-4 1.088E-2
7.677E-2
3.373E-1
 2 143
32 GTCTTCC,MIR-7:MSigDB GTCTTCC,MIR-7:MSigDB MSigDB 6.090E-4 1.231E-2
8.681E-2
3.959E-1
 2 155
33 hsa-miR-7158-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.247E-4 1.231E-2
8.681E-2
4.061E-1
 2 157
34 GTGCCAT,MIR-183:MSigDB GTGCCAT,MIR-183:MSigDB MSigDB 6.895E-4 1.318E-2
9.299E-2
4.482E-1
 2 165
35 hsa-miR-205-5p:Functional MTI Functional MTI miRTarbase 8.374E-4 1.555E-2
1.097E-1
5.443E-1
 2 182
36 GTATTAT,MIR-369-3P:MSigDB GTATTAT,MIR-369-3P:MSigDB MSigDB 9.118E-4 1.646E-2
1.161E-1
5.927E-1
 2 190
37 hsa-miR-146a-5p:Functional MTI Functional MTI miRTarbase 1.029E-3 1.808E-2
1.276E-1
6.690E-1
 2 202
38 hsa-miR-5590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.132E-3 1.937E-2
1.366E-1
7.360E-1
 2 212
39 TAGCTTT,MIR-9:MSigDB TAGCTTT,MIR-9:MSigDB MSigDB 1.274E-3 2.069E-2
1.460E-1
8.278E-1
 2 225
40 hsa-miR-142-5p:Functional MTI Functional MTI miRTarbase 1.274E-3 2.069E-2
1.460E-1
8.278E-1
 2 225
41 hsa-miR-1279:PITA hsa-miR-1279:PITA TOP PITA 1.423E-3 2.256E-2
1.591E-1
9.248E-1
 2 238
42 hsa-miR-569:PITA hsa-miR-569:PITA TOP PITA 1.470E-3 2.275E-2
1.605E-1
9.557E-1
 2 242
43 hsa-miR-542-3p:TargetScan hsa-miR-542-3p TargetScan 1.668E-3 2.342E-2
1.652E-1
1.000E0
 2 258
44 hsa-miR-548n:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.693E-3 2.342E-2
1.652E-1
1.000E0
 2 260
45 hsa-miR-18a-5p:Functional MTI Functional MTI miRTarbase 1.719E-3 2.342E-2
1.652E-1
1.000E0
 2 262
46 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 1.745E-3 2.342E-2
1.652E-1
1.000E0
 2 264
47 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 1.771E-3 2.342E-2
1.652E-1
1.000E0
 2 266
48 hsa-miR-548t-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.811E-3 2.342E-2
1.652E-1
1.000E0
 2 269
49 hsa-miR-548az-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.811E-3 2.342E-2
1.652E-1
1.000E0
 2 269
50 hsa-miR-93-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.811E-3 2.342E-2
1.652E-1
1.000E0
 2 269
Show 45 more annotations

17: Drug [Display Chart] 17 input genes in category / 5531 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000061671 vanadyl Stitch 2.128E-11 1.177E-7 1.082E-6 1.177E-7 8 307
2 CID000004813 AC1L1J0H Stitch 5.768E-11 1.595E-7 1.467E-6 3.190E-7 7 197
3 CID000003591 AC1L1G9T Stitch 1.384E-8 1.975E-5 1.816E-4 7.654E-5 7 433
4 CID000061672 orthovanadate Stitch 1.428E-8 1.975E-5 1.816E-4 7.901E-5 7 435
5 CID005362399 bemoradan Stitch 1.913E-8 2.116E-5 1.946E-4 1.058E-4 3 8
6 CID000027107 Ta 2 Stitch 1.549E-7 6.884E-5 6.330E-4 8.570E-4 3 15
7 CID000003501 Go6976 Stitch 2.156E-7 6.884E-5 6.330E-4 1.192E-3 5 190
8 CID000131100 Org 9935 Stitch 2.314E-7 6.884E-5 6.330E-4 1.280E-3 3 17
9 CID000003541 AC1MBZ1C Stitch 2.406E-7 6.884E-5 6.330E-4 1.330E-3 6 387
10 CID000448157 AC1L9LNU Stitch 3.207E-7 6.884E-5 6.330E-4 1.774E-3 4 80
11 CID002735893 3-cyclopentyloxy-4-methoxybenzaldehyde Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
12 DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Drug Bank 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
13 CID011168555 V11294 Analogue 5r Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
14 DB03849 Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid Drug Bank 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
15 CID006918355 T-2585.HCl Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
16 CID009999276 Np-V Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
17 CID011478659 V11294 Analogue 5p Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
18 CID011375325 V11294 Analogue 5v Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
19 CID011443760 V11294 Analogue 5b Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
20 CID006420180 M 98 Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
21 CID011249748 V11294 Analogue 5o Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
22 CID011238279 V11294 Analogue 5n Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
23 CID011179896 V11294 Analogue 5c Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
24 CID011226695 V11294 Analogue 5t Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
25 CID011433797 V11294 Analogue 5j Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
26 CID011318772 V11294 Analogue 5q Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
27 CID011456440 V11294 Analogue 5k Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
28 CID011283750 V11294 Analogue 5d Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
29 CID002779323 3-cyclopentyloxy-4-methoxybenzoic acid Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
30 CID011443441 V11294 Analogue 5e Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
31 CID011214587 V11294 Analogue 5f Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
32 CID011386897 V11294 Analogue 5a Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
33 DB03606 (S)-Rolipram Drug Bank 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
34 CID011306698 V11294 Analogue 5h Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
35 ctd:C554440 1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester CTD 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
36 CID011442865 V11294 Analogue 8a Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
37 CID011477773 V11294 Analogue 5m Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
38 DB01954 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone Drug Bank 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
39 CID011376249 V11294 Analogue 5i Stitch 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
40 DB04149 (R)-Rolipram Drug Bank 5.214E-7 6.884E-5 6.330E-4 2.884E-3 2 2
41 CID003025803 tetomilast Stitch 5.228E-7 6.884E-5 6.330E-4 2.891E-3 3 22
42 CID000193659 EW-1 Stitch 5.228E-7 6.884E-5 6.330E-4 2.891E-3 3 22
43 CID000123882 TAK-044 Stitch 7.797E-7 1.003E-4 9.222E-4 4.312E-3 3 25
44 CID000030627 Capobenic acid Stitch 9.906E-7 1.245E-4 1.145E-3 5.479E-3 3 27
45 CID000003795 WHI-P154 Stitch 1.520E-6 1.765E-4 1.623E-3 8.405E-3 3 31
46 CID000118838 1-Pyrrolidinebutanenitrile Stitch 1.563E-6 1.765E-4 1.623E-3 8.648E-3 2 3
47 CID000166560 Org 4428 Stitch 1.563E-6 1.765E-4 1.623E-3 8.648E-3 2 3
48 CID000127779 BW A78U Stitch 1.563E-6 1.765E-4 1.623E-3 8.648E-3 2 3
49 DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Drug Bank 1.563E-6 1.765E-4 1.623E-3 8.648E-3 2 3
50 CID000002061 tyrphostin 25 Stitch 1.747E-6 1.923E-4 1.768E-3 9.664E-3 4 122
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 812 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C4021651 Hypoplasia of the nasal bone DisGeNET Curated 1.036E-6 4.206E-4 3.061E-3 8.411E-4 2 2
2 C4024667 Congenital craniofacial dysostosis DisGeNET Curated 1.036E-6 4.206E-4 3.061E-3 8.411E-4 2 2
3 C0027149 Myxoma DisGeNET BeFree 1.915E-6 5.182E-4 3.771E-3 1.555E-3 3 24
4 C1868394 Elevated calcitonin DisGeNET Curated 3.106E-6 6.304E-4 4.588E-3 2.522E-3 2 3
5 C0079773 Lymphoma, T-Cell, Cutaneous DisGeNET Curated 4.209E-6 6.836E-4 4.975E-3 3.418E-3 5 247
6 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 7.493E-6 7.632E-4 5.554E-3 6.084E-3 6 497
7 C0024131 Lupus Vulgaris DisGeNET BeFree 9.045E-6 7.632E-4 5.554E-3 7.345E-3 5 289
8 C0409974 Lupus Erythematosus DisGeNET BeFree 1.016E-5 7.632E-4 5.554E-3 8.249E-3 5 296
9 C3830467 Disseminated Bacillus Calmette-Guerin infection DisGeNET BeFree 1.034E-5 7.632E-4 5.554E-3 8.396E-3 2 5
10 C1856639 Absent/hypoplastic paranasal sinuses DisGeNET Curated 1.034E-5 7.632E-4 5.554E-3 8.396E-3 2 5
11 C1832598 Narrow interpedicular space DisGeNET Curated 1.034E-5 7.632E-4 5.554E-3 8.396E-3 2 5
12 C0024138 Lupus Erythematosus, Discoid DisGeNET Curated 1.138E-5 7.699E-4 5.603E-3 9.239E-3 5 303
13 C0239803 Red hair DisGeNET Curated 1.550E-5 9.681E-4 7.045E-3 1.259E-2 2 6
14 C1863353 Hypoplastic vertebral bodies DisGeNET Curated 2.169E-5 1.174E-3 8.543E-3 1.761E-2 2 7
15 C4023438 Recurrent mycobacterial infections DisGeNET Curated 2.169E-5 1.174E-3 8.543E-3 1.761E-2 2 7
16 C4021822 Abnormality of female external genitalia DisGeNET Curated 2.890E-5 1.467E-3 1.067E-2 2.346E-2 2 8
17 C0398686 Primary immune deficiency disorder DisGeNET BeFree 6.180E-5 2.952E-3 2.148E-2
5.018E-2
 3 75
18 C3150077 Short stature, mild DisGeNET Curated 8.025E-5 3.430E-3 2.496E-2
6.516E-2
 2 13
19 C4020838 Relative short stature DisGeNET Curated 8.025E-5 3.430E-3 2.496E-2
6.516E-2
 2 13
20 C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 9.127E-5 3.453E-3 2.513E-2
7.411E-2
 5 468
21 C0857973 Increased serum parathyroid hormone DisGeNET Curated 9.357E-5 3.453E-3 2.513E-2
7.598E-2
 2 14
22 C0553706 SERUM PHOSPHATE ELEVATED DisGeNET Curated 9.357E-5 3.453E-3 2.513E-2
7.598E-2
 2 14
23 C4023616 Abnormality of immune system physiology DisGeNET Curated 1.232E-4 4.169E-3 3.034E-2
1.001E-1
 2 16
24 C1861329 Spinal canal stenosis DisGeNET Curated 1.232E-4 4.169E-3 3.034E-2
1.001E-1
 2 16
25 C0578626 blue iris (physical finding) DisGeNET Curated 1.396E-4 4.359E-3 3.172E-2
1.133E-1
 2 17
26 C0220659 Acrodysostosis DisGeNET Curated 1.396E-4 4.359E-3 3.172E-2
1.133E-1
 2 17
27 C0151945 Thrombosis of cerebral veins DisGeNET Curated 1.569E-4 4.719E-3 3.435E-2
1.274E-1
 2 18
28 C0276226 Herpes encephalitis DisGeNET Curated 1.753E-4 5.083E-3 3.699E-2
1.423E-1
 2 19
29 C3887645 Job Syndrome DisGeNET Curated 2.150E-4 5.819E-3 4.235E-2
1.746E-1
 2 21
30 C1849020 Short metatarsal DisGeNET Curated 2.150E-4 5.819E-3 4.235E-2
1.746E-1
 2 21
31 C0085681 Hyperphosphatemia (disorder) DisGeNET Curated 2.363E-4 5.997E-3 4.364E-2
1.919E-1
 2 22
32 C0853087 Nail abnormality DisGeNET Curated 2.363E-4 5.997E-3 4.364E-2
1.919E-1
 2 22
33 C1840087 Radial ray hypoplasia DisGeNET Curated 2.587E-4 6.027E-3 4.386E-2
2.101E-1
 2 23
34 C1862132 Short ulnae DisGeNET Curated 2.820E-4 6.027E-3 4.386E-2
2.290E-1
 2 24
35 C1860614 ULNAR HYPOPLASIA DisGeNET Curated 2.820E-4 6.027E-3 4.386E-2
2.290E-1
 2 24
36 C1865037 Cone-shaped epiphyses DisGeNET Curated 2.820E-4 6.027E-3 4.386E-2
2.290E-1
 2 24
37 C0033806 Pseudohypoparathyroidism DisGeNET Curated 2.820E-4 6.027E-3 4.386E-2
2.290E-1
 2 24
38 C0685381 Congenital hypoplasia of radius DisGeNET Curated 2.820E-4 6.027E-3 4.386E-2
2.290E-1
 2 24
39 C0027339 Nail Diseases DisGeNET Curated 3.580E-4 7.090E-3
5.160E-2
2.907E-1
 2 27
40 C0009663 Condylomata Acuminata DisGeNET BeFree 3.580E-4 7.090E-3
5.160E-2
2.907E-1
 2 27
41 C0151740 Intracranial Hypertension DisGeNET Curated 3.580E-4 7.090E-3
5.160E-2
2.907E-1
 2 27
42 C1859126 Stippled epiphyses DisGeNET Curated 3.853E-4 7.450E-3
5.421E-2
3.129E-1
 2 28
43 C0023492 Leukemia, T-Cell DisGeNET Curated 4.299E-4 8.119E-3
5.908E-2
3.491E-1
 4 355
44 C2752147 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C DisGeNET Curated 4.429E-4 8.173E-3
5.948E-2
3.596E-1
 2 30
45 C1836195 Hypoplastic toes DisGeNET Curated 4.731E-4 8.270E-3
6.019E-2
3.842E-1
 2 31
46 C1839326 Abnormally-shaped vertebrae DisGeNET Curated 4.731E-4 8.270E-3
6.019E-2
3.842E-1
 2 31
47 C0877165 Short phalanx of finger DisGeNET Curated 5.044E-4 8.270E-3
6.019E-2
4.095E-1
 2 32
48 C0001815 Primary Myelofibrosis DisGeNET Curated 6.125E-4 8.270E-3
6.019E-2
4.973E-1
 3 163
49 C0006413 Burkitt Lymphoma DisGeNET Curated 6.131E-4 8.270E-3
6.019E-2
4.979E-1
 4 390
50 C0545053 Advanced bone age DisGeNET Curated 6.390E-4 8.270E-3
6.019E-2
5.189E-1
 2 36
Show 45 more annotations