1: GO: Molecular Function [Display Chart]
7 input genes in category / 68 annotations before applied cutoff / 18661 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0005114
|
type II transforming growth factor beta receptor binding
|
|
1.809E-9
|
1.230E-7
|
5.908E-7
|
1.230E-7
|
3
|
8
|
2
|
GO:0050431
|
transforming growth factor beta binding
|
|
2.631E-8
|
8.946E-7
|
4.297E-6
|
1.789E-6
|
3
|
18
|
3
|
GO:0005160
|
transforming growth factor beta receptor binding
|
|
7.511E-7
|
1.702E-5
|
8.179E-5
|
5.107E-5
|
3
|
53
|
4
|
GO:0005024
|
transforming growth factor beta-activated receptor activity
|
|
5.420E-6
|
6.375E-5
|
3.062E-4
|
3.686E-4
|
2
|
10
|
5
|
GO:0034713
|
type I transforming growth factor beta receptor binding
|
|
5.420E-6
|
6.375E-5
|
3.062E-4
|
3.686E-4
|
2
|
10
|
6
|
GO:0019955
|
cytokine binding
|
|
5.625E-6
|
6.375E-5
|
3.062E-4
|
3.825E-4
|
3
|
103
|
7
|
GO:0019838
|
growth factor binding
|
|
1.477E-5
|
1.434E-4
|
6.891E-4
|
1.004E-3
|
3
|
142
|
8
|
GO:0004675
|
transmembrane receptor protein serine/threonine kinase activity
|
|
3.316E-5
|
2.819E-4
|
1.354E-3
|
2.255E-3
|
2
|
24
|
9
|
GO:0005126
|
cytokine receptor binding
|
|
1.229E-4
|
9.283E-4
|
4.460E-3
|
8.355E-3
|
3
|
289
|
10
|
GO:0004674
|
protein serine/threonine kinase activity
|
|
4.595E-4
|
3.005E-3
|
1.444E-2
|
3.125E-2
|
3
|
452
|
11
|
GO:0019199
|
transmembrane receptor protein kinase activity
|
|
4.861E-4
|
3.005E-3
|
1.444E-2
|
3.306E-2
|
2
|
91
|
12
|
GO:0002135
|
CTP binding
|
|
7.501E-4
|
4.251E-3
|
2.042E-2
|
5.101E-2
|
1
|
2
|
13
|
GO:0017098
|
sulfonylurea receptor binding
|
|
1.125E-3
|
5.542E-3
|
2.662E-2
|
7.650E-2
|
1
|
3
|
14
|
GO:0005025
|
transforming growth factor beta receptor activity, type I
|
|
1.500E-3
|
5.542E-3
|
2.662E-2
|
1.020E-1
|
1
|
4
|
15
|
GO:0034714
|
type III transforming growth factor beta receptor binding
|
|
1.500E-3
|
5.542E-3
|
2.662E-2
|
1.020E-1
|
1
|
4
|
16
|
GO:0032551
|
pyrimidine ribonucleoside binding
|
|
1.500E-3
|
5.542E-3
|
2.662E-2
|
1.020E-1
|
1
|
4
|
17
|
GO:0032564
|
dATP binding
|
|
1.500E-3
|
5.542E-3
|
2.662E-2
|
1.020E-1
|
1
|
4
|
18
|
GO:0002134
|
UTP binding
|
|
1.500E-3
|
5.542E-3
|
2.662E-2
|
1.020E-1
|
1
|
4
|
19
|
GO:0030911
|
TPR domain binding
|
|
1.874E-3
|
5.542E-3
|
2.662E-2
|
1.275E-1
|
1
|
5
|
20
|
GO:0032558
|
adenyl deoxyribonucleotide binding
|
|
1.874E-3
|
5.542E-3
|
2.662E-2
|
1.275E-1
|
1
|
5
|
21
|
GO:0051022
|
Rho GDP-dissociation inhibitor binding
|
|
1.874E-3
|
5.542E-3
|
2.662E-2
|
1.275E-1
|
1
|
5
|
22
|
GO:0001884
|
pyrimidine nucleoside binding
|
|
1.874E-3
|
5.542E-3
|
2.662E-2
|
1.275E-1
|
1
|
5
|
23
|
GO:0032557
|
pyrimidine ribonucleotide binding
|
|
1.874E-3
|
5.542E-3
|
2.662E-2
|
1.275E-1
|
1
|
5
|
24
|
GO:0032554
|
purine deoxyribonucleotide binding
|
|
2.249E-3
|
6.117E-3
|
2.939E-2
|
1.529E-1
|
1
|
6
|
25
|
GO:0051021
|
GDP-dissociation inhibitor binding
|
|
2.249E-3
|
6.117E-3
|
2.939E-2
|
1.529E-1
|
1
|
6
|
26
|
GO:0005534
|
galactose binding
|
|
2.623E-3
|
6.861E-3
|
3.296E-2
|
1.784E-1
|
1
|
7
|
27
|
GO:0032552
|
deoxyribonucleotide binding
|
|
2.998E-3
|
7.549E-3
|
3.627E-2
|
2.038E-1
|
1
|
8
|
28
|
GO:0098748
|
endocytic adaptor activity
|
|
3.372E-3
|
7.906E-3
|
3.798E-2
|
2.293E-1
|
1
|
9
|
29
|
GO:0035615
|
clathrin adaptor activity
|
|
3.372E-3
|
7.906E-3
|
3.798E-2
|
2.293E-1
|
1
|
9
|
30
|
GO:0005072
|
transforming growth factor beta receptor, cytoplasmic mediator activity
|
|
3.746E-3
|
8.216E-3
|
3.947E-2
|
2.547E-1
|
1
|
10
|
31
|
GO:0030235
|
nitric-oxide synthase regulator activity
|
|
3.746E-3
|
8.216E-3
|
3.947E-2
|
2.547E-1
|
1
|
10
|
32
|
GO:0036122
|
BMP binding
|
|
4.120E-3
|
8.239E-3
|
3.958E-2
|
2.801E-1
|
1
|
11
|
33
|
GO:0070411
|
I-SMAD binding
|
|
4.120E-3
|
8.239E-3
|
3.958E-2
|
2.801E-1
|
1
|
11
|
34
|
GO:0019103
|
pyrimidine nucleotide binding
|
|
4.120E-3
|
8.239E-3
|
3.958E-2
|
2.801E-1
|
1
|
11
|
35
|
GO:0048185
|
activin binding
|
|
4.867E-3
|
9.456E-3
|
4.543E-2
|
3.310E-1
|
1
|
13
|
36
|
GO:0048156
|
tau protein binding
|
|
5.241E-3
|
9.899E-3
|
4.756E-2
|
3.564E-1
|
1
|
14
|
37
|
GO:0023026
|
MHC class II protein complex binding
|
|
5.987E-3
|
1.100E-2
|
5.286E-2
|
4.071E-1
|
1
|
16
|
38
|
GO:0023023
|
MHC protein complex binding
|
|
7.107E-3
|
1.272E-2
|
6.109E-2
|
4.832E-1
|
1
|
19
|
39
|
GO:0097472
|
cyclin-dependent protein kinase activity
|
|
1.306E-2
|
2.220E-2
|
1.066E-1
|
8.879E-1
|
1
|
35
|
40
|
GO:0004693
|
cyclin-dependent protein serine/threonine kinase activity
|
|
1.306E-2
|
2.220E-2
|
1.066E-1
|
8.879E-1
|
1
|
35
|
41
|
GO:0005048
|
signal sequence binding
|
|
1.565E-2
|
2.596E-2
|
1.247E-1
|
1.000E0
|
1
|
42
|
42
|
GO:0030276
|
clathrin binding
|
|
2.450E-2
|
3.967E-2
|
1.906E-1
|
1.000E0
|
1
|
66
|
43
|
GO:0046332
|
SMAD binding
|
|
2.853E-2
|
4.512E-2
|
2.168E-1
|
1.000E0
|
1
|
77
|
44
|
GO:0048029
|
monosaccharide binding
|
|
2.963E-2
|
4.579E-2
|
2.200E-1
|
1.000E0
|
1
|
80
|
Show 39 more annotations
|
2: GO: Biological Process [Display Chart]
7 input genes in category / 523 annotations before applied cutoff / 18623 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0060393
|
regulation of pathway-restricted SMAD protein phosphorylation
|
|
3.619E-9
|
7.830E-7
|
5.354E-6
|
1.893E-6
|
4
|
61
|
2
|
GO:0060389
|
pathway-restricted SMAD protein phosphorylation
|
|
4.404E-9
|
7.830E-7
|
5.354E-6
|
2.304E-6
|
4
|
64
|
3
|
GO:0030512
|
negative regulation of transforming growth factor beta receptor signaling pathway
|
|
5.989E-9
|
7.830E-7
|
5.354E-6
|
3.132E-6
|
4
|
69
|
4
|
GO:1903845
|
negative regulation of cellular response to transforming growth factor beta stimulus
|
|
5.989E-9
|
7.830E-7
|
5.354E-6
|
3.132E-6
|
4
|
69
|
5
|
GO:0017015
|
regulation of transforming growth factor beta receptor signaling pathway
|
|
3.296E-8
|
2.873E-6
|
1.965E-5
|
1.724E-5
|
4
|
105
|
6
|
GO:1903844
|
regulation of cellular response to transforming growth factor beta stimulus
|
|
3.296E-8
|
2.873E-6
|
1.965E-5
|
1.724E-5
|
4
|
105
|
7
|
GO:0090101
|
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
|
|
3.978E-8
|
2.972E-6
|
2.032E-5
|
2.081E-5
|
4
|
110
|
8
|
GO:0090288
|
negative regulation of cellular response to growth factor stimulus
|
|
9.089E-8
|
5.942E-6
|
4.063E-5
|
4.754E-5
|
4
|
135
|
9
|
GO:0070483
|
detection of hypoxia
|
|
1.211E-7
|
7.038E-6
|
4.812E-5
|
6.334E-5
|
2
|
2
|
10
|
GO:0007179
|
transforming growth factor beta receptor signaling pathway
|
|
3.154E-7
|
1.650E-5
|
1.128E-4
|
1.650E-4
|
4
|
184
|
11
|
GO:0010862
|
positive regulation of pathway-restricted SMAD protein phosphorylation
|
|
5.947E-7
|
2.828E-5
|
1.933E-4
|
3.110E-4
|
3
|
49
|
12
|
GO:0090092
|
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
|
|
6.689E-7
|
2.915E-5
|
1.993E-4
|
3.498E-4
|
4
|
222
|
13
|
GO:0071560
|
cellular response to transforming growth factor beta stimulus
|
|
7.706E-7
|
3.032E-5
|
2.073E-4
|
4.030E-4
|
4
|
230
|
14
|
GO:0071559
|
response to transforming growth factor beta
|
|
8.115E-7
|
3.032E-5
|
2.073E-4
|
4.244E-4
|
4
|
233
|
15
|
GO:0090287
|
regulation of cellular response to growth factor stimulus
|
|
1.182E-6
|
3.957E-5
|
2.705E-4
|
6.181E-4
|
4
|
256
|
16
|
GO:0003032
|
detection of oxygen
|
|
1.210E-6
|
3.957E-5
|
2.705E-4
|
6.331E-4
|
2
|
5
|
17
|
GO:0060485
|
mesenchyme development
|
|
1.336E-6
|
4.111E-5
|
2.811E-4
|
6.988E-4
|
4
|
264
|
18
|
GO:0010717
|
regulation of epithelial to mesenchymal transition
|
|
1.761E-6
|
5.117E-5
|
3.499E-4
|
9.210E-4
|
3
|
70
|
19
|
GO:0060840
|
artery development
|
|
3.767E-6
|
9.907E-5
|
6.774E-4
|
1.970E-3
|
3
|
90
|
20
|
GO:0007178
|
transmembrane receptor protein serine/threonine kinase signaling pathway
|
|
3.788E-6
|
9.907E-5
|
6.774E-4
|
1.981E-3
|
4
|
343
|
21
|
GO:0090100
|
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
|
|
5.997E-6
|
1.462E-4
|
1.000E-3
|
3.136E-3
|
3
|
105
|
22
|
GO:0042307
|
positive regulation of protein import into nucleus
|
|
6.170E-6
|
1.462E-4
|
1.000E-3
|
3.227E-3
|
3
|
106
|
23
|
GO:0060394
|
negative regulation of pathway-restricted SMAD protein phosphorylation
|
|
6.650E-6
|
1.462E-4
|
1.000E-3
|
3.478E-3
|
2
|
11
|
24
|
GO:1904591
|
positive regulation of protein import
|
|
6.711E-6
|
1.462E-4
|
1.000E-3
|
3.510E-3
|
3
|
109
|
25
|
GO:0060391
|
positive regulation of SMAD protein signal transduction
|
|
7.979E-6
|
1.669E-4
|
1.141E-3
|
4.173E-3
|
2
|
12
|
26
|
GO:0001837
|
epithelial to mesenchymal transition
|
|
8.305E-6
|
1.671E-4
|
1.142E-3
|
4.344E-3
|
3
|
117
|
27
|
GO:0046824
|
positive regulation of nucleocytoplasmic transport
|
|
1.088E-5
|
2.103E-4
|
1.438E-3
|
5.690E-3
|
3
|
128
|
28
|
GO:0050680
|
negative regulation of epithelial cell proliferation
|
|
1.140E-5
|
2.103E-4
|
1.438E-3
|
5.961E-3
|
3
|
130
|
29
|
GO:2000736
|
regulation of stem cell differentiation
|
|
1.166E-5
|
2.103E-4
|
1.438E-3
|
6.100E-3
|
3
|
131
|
30
|
GO:1900182
|
positive regulation of protein localization to nucleus
|
|
1.364E-5
|
2.377E-4
|
1.625E-3
|
7.131E-3
|
3
|
138
|
31
|
GO:0060390
|
regulation of SMAD protein signal transduction
|
|
1.450E-5
|
2.446E-4
|
1.672E-3
|
7.582E-3
|
2
|
16
|
32
|
GO:0003272
|
endocardial cushion formation
|
|
1.848E-5
|
3.020E-4
|
2.065E-3
|
9.663E-3
|
2
|
18
|
33
|
GO:0060491
|
regulation of cell projection assembly
|
|
2.730E-5
|
4.326E-4
|
2.958E-3
|
1.428E-2
|
3
|
174
|
34
|
GO:0014031
|
mesenchymal cell development
|
|
3.332E-5
|
5.041E-4
|
3.447E-3
|
1.742E-2
|
3
|
186
|
35
|
GO:0042306
|
regulation of protein import into nucleus
|
|
3.440E-5
|
5.041E-4
|
3.447E-3
|
1.799E-2
|
3
|
188
|
36
|
GO:0003203
|
endocardial cushion morphogenesis
|
|
3.618E-5
|
5.041E-4
|
3.447E-3
|
1.892E-2
|
2
|
25
|
37
|
GO:0048864
|
stem cell development
|
|
3.663E-5
|
5.041E-4
|
3.447E-3
|
1.916E-2
|
3
|
192
|
38
|
GO:1904589
|
regulation of protein import
|
|
3.663E-5
|
5.041E-4
|
3.447E-3
|
1.916E-2
|
3
|
192
|
39
|
GO:0048762
|
mesenchymal cell differentiation
|
|
4.137E-5
|
5.533E-4
|
3.783E-3
|
2.164E-2
|
3
|
200
|
40
|
GO:0060317
|
cardiac epithelial to mesenchymal transition
|
|
4.232E-5
|
5.533E-4
|
3.783E-3
|
2.213E-2
|
2
|
27
|
41
|
GO:0032967
|
positive regulation of collagen biosynthetic process
|
|
4.893E-5
|
6.242E-4
|
4.268E-3
|
2.559E-2
|
2
|
29
|
42
|
GO:0051491
|
positive regulation of filopodium assembly
|
|
5.242E-5
|
6.376E-4
|
4.359E-3
|
2.741E-2
|
2
|
30
|
43
|
GO:0010714
|
positive regulation of collagen metabolic process
|
|
5.242E-5
|
6.376E-4
|
4.359E-3
|
2.741E-2
|
2
|
30
|
44
|
GO:0001937
|
negative regulation of endothelial cell proliferation
|
|
6.359E-5
|
7.537E-4
|
5.154E-3
|
3.326E-2
|
2
|
33
|
45
|
GO:0043627
|
response to estrogen
|
|
6.604E-5
|
7.537E-4
|
5.154E-3
|
3.454E-2
|
3
|
234
|
46
|
GO:1900180
|
regulation of protein localization to nucleus
|
|
6.689E-5
|
7.537E-4
|
5.154E-3
|
3.498E-2
|
3
|
235
|
47
|
GO:0046822
|
regulation of nucleocytoplasmic transport
|
|
6.774E-5
|
7.537E-4
|
5.154E-3
|
3.543E-2
|
3
|
236
|
48
|
GO:0003007
|
heart morphogenesis
|
|
8.232E-5
|
8.970E-4
|
6.133E-3
|
4.305E-2
|
3
|
252
|
49
|
GO:0003197
|
endocardial cushion development
|
|
8.459E-5
|
9.029E-4
|
6.174E-3
|
4.424E-2
|
2
|
38
|
50
|
GO:0032965
|
regulation of collagen biosynthetic process
|
|
9.382E-5
|
9.814E-4
|
6.711E-3
|
4.907E-2
|
2
|
40
|
Show 45 more annotations
|
3: GO: Cellular Component [Display Chart]
7 input genes in category / 83 annotations before applied cutoff / 19061 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0070022
|
transforming growth factor beta receptor complex
|
|
6.934E-7
|
5.755E-5
|
2.879E-4
|
5.755E-5
|
2
|
4
|
2
|
GO:1902554
|
serine/threonine protein kinase complex
|
|
3.694E-4
|
8.708E-3
|
4.356E-2
|
3.066E-2
|
2
|
81
|
3
|
GO:1902911
|
protein kinase complex
|
|
4.764E-4
|
8.708E-3
|
4.356E-2
|
3.954E-2
|
2
|
92
|
4
|
GO:0060205
|
cytoplasmic vesicle lumen
|
|
6.082E-4
|
8.708E-3
|
4.356E-2
|
5.048E-2
|
2
|
104
|
5
|
GO:0031983
|
vesicle lumen
|
|
6.557E-4
|
8.708E-3
|
4.356E-2
|
5.442E-2
|
2
|
108
|
6
|
GO:0097226
|
sperm mitochondrial sheath
|
|
7.344E-4
|
8.708E-3
|
4.356E-2
|
6.095E-2
|
1
|
2
|
7
|
GO:0072563
|
endothelial microparticle
|
|
7.344E-4
|
8.708E-3
|
4.356E-2
|
6.095E-2
|
1
|
2
|
8
|
GO:0097524
|
sperm plasma membrane
|
|
1.468E-3
|
1.523E-2
|
7.620E-2
|
1.219E-1
|
1
|
4
|
9
|
GO:0098802
|
plasma membrane receptor complex
|
|
1.805E-3
|
1.665E-2
|
8.328E-2
|
1.498E-1
|
2
|
180
|
10
|
GO:0016323
|
basolateral plasma membrane
|
|
3.285E-3
|
2.467E-2
|
1.234E-1
|
2.726E-1
|
2
|
244
|
11
|
GO:0061695
|
transferase complex, transferring phosphorus-containing groups
|
|
3.285E-3
|
2.467E-2
|
1.234E-1
|
2.726E-1
|
2
|
244
|
12
|
GO:0030139
|
endocytic vesicle
|
|
3.862E-3
|
2.467E-2
|
1.234E-1
|
3.205E-1
|
2
|
265
|
13
|
GO:0036020
|
endolysosome membrane
|
|
4.399E-3
|
2.467E-2
|
1.234E-1
|
3.651E-1
|
1
|
12
|
14
|
GO:0032797
|
SMN complex
|
|
4.765E-3
|
2.467E-2
|
1.234E-1
|
3.955E-1
|
1
|
13
|
15
|
GO:0030122
|
AP-2 adaptor complex
|
|
4.765E-3
|
2.467E-2
|
1.234E-1
|
3.955E-1
|
1
|
13
|
16
|
GO:0030128
|
clathrin coat of endocytic vesicle
|
|
5.131E-3
|
2.467E-2
|
1.234E-1
|
4.259E-1
|
1
|
14
|
17
|
GO:0016324
|
apical plasma membrane
|
|
6.101E-3
|
2.467E-2
|
1.234E-1
|
5.064E-1
|
2
|
335
|
18
|
GO:0034719
|
SMN-Sm protein complex
|
|
6.227E-3
|
2.467E-2
|
1.234E-1
|
5.169E-1
|
1
|
17
|
19
|
GO:0036019
|
endolysosome
|
|
6.227E-3
|
2.467E-2
|
1.234E-1
|
5.169E-1
|
1
|
17
|
20
|
GO:0071682
|
endocytic vesicle lumen
|
|
6.227E-3
|
2.467E-2
|
1.234E-1
|
5.169E-1
|
1
|
17
|
21
|
GO:0043235
|
receptor complex
|
|
6.243E-3
|
2.467E-2
|
1.234E-1
|
5.182E-1
|
2
|
339
|
22
|
GO:0030132
|
clathrin coat of coated pit
|
|
6.958E-3
|
2.625E-2
|
1.313E-1
|
5.775E-1
|
1
|
19
|
23
|
GO:0030125
|
clathrin vesicle coat
|
|
9.146E-3
|
3.301E-2
|
1.651E-1
|
7.592E-1
|
1
|
25
|
24
|
GO:0045177
|
apical part of cell
|
|
9.803E-3
|
3.390E-2
|
1.696E-1
|
8.136E-1
|
2
|
428
|
25
|
GO:0031012
|
extracellular matrix
|
|
1.052E-2
|
3.493E-2
|
1.747E-1
|
8.732E-1
|
2
|
444
|
26
|
GO:0030131
|
clathrin adaptor complex
|
|
1.097E-2
|
3.501E-2
|
1.751E-1
|
9.103E-1
|
1
|
30
|
Show 21 more annotations
|
4: Human Phenotype [Display Chart]
3 input genes in category / 361 annotations before applied cutoff / 4707 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
HP:0030872
|
Abnormal cardiac ventricular function
|
|
1.199E-6
|
2.083E-4
|
1.347E-3
|
4.328E-4
|
3
|
51
|
2
|
HP:0004944
|
Dilatation of the cerebral artery
|
|
1.684E-6
|
2.083E-4
|
1.347E-3
|
6.081E-4
|
3
|
57
|
3
|
HP:0000965
|
Cutis marmorata
|
|
2.634E-6
|
2.083E-4
|
1.347E-3
|
9.510E-4
|
3
|
66
|
4
|
HP:0002138
|
Subarachnoid hemorrhage
|
|
2.758E-6
|
2.083E-4
|
1.347E-3
|
9.956E-4
|
3
|
67
|
5
|
HP:0012703
|
Abnormality of the subarachnoid space
|
|
2.885E-6
|
2.083E-4
|
1.347E-3
|
1.042E-3
|
3
|
68
|
6
|
HP:0002326
|
Transient ischemic attack
|
|
5.892E-6
|
3.545E-4
|
2.293E-3
|
2.127E-3
|
3
|
86
|
7
|
HP:0001342
|
Cerebral hemorrhage
|
|
1.312E-5
|
5.439E-4
|
3.518E-3
|
4.737E-3
|
3
|
112
|
8
|
HP:0002140
|
Ischemic stroke
|
|
1.874E-5
|
5.439E-4
|
3.518E-3
|
6.765E-3
|
3
|
126
|
9
|
HP:0012180
|
Cystic medial necrosis
|
|
2.109E-5
|
5.439E-4
|
3.518E-3
|
7.615E-3
|
2
|
13
|
10
|
HP:0012763
|
Paroxysmal dyspnea
|
|
2.109E-5
|
5.439E-4
|
3.518E-3
|
7.615E-3
|
2
|
13
|
11
|
HP:0004954
|
Dilatation of the descending aortic
|
|
2.109E-5
|
5.439E-4
|
3.518E-3
|
7.615E-3
|
2
|
13
|
12
|
HP:0012499
|
Descending aortic dissection
|
|
2.109E-5
|
5.439E-4
|
3.518E-3
|
7.615E-3
|
2
|
13
|
13
|
HP:0004959
|
Descending thoracic aorta aneurysm
|
|
2.109E-5
|
5.439E-4
|
3.518E-3
|
7.615E-3
|
2
|
13
|
14
|
HP:0200146
|
Mucoid extracellular matrix accumulation
|
|
2.109E-5
|
5.439E-4
|
3.518E-3
|
7.615E-3
|
2
|
13
|
15
|
HP:0002617
|
Dilatation
|
|
2.361E-5
|
5.552E-4
|
3.591E-3
|
8.522E-3
|
3
|
136
|
16
|
HP:0012163
|
Carotid artery dilatation
|
|
2.461E-5
|
5.552E-4
|
3.591E-3
|
8.883E-3
|
2
|
14
|
17
|
HP:0002105
|
Hemoptysis
|
|
4.079E-5
|
8.662E-4
|
5.602E-3
|
1.473E-2
|
3
|
163
|
18
|
HP:0100775
|
Dural ectasia
|
|
4.621E-5
|
8.779E-4
|
5.678E-3
|
1.668E-2
|
2
|
19
|
19
|
HP:0004933
|
Ascending aortic dissection
|
|
4.621E-5
|
8.779E-4
|
5.678E-3
|
1.668E-2
|
2
|
19
|
20
|
HP:0002170
|
Intracranial hemorrhage
|
|
5.411E-5
|
9.487E-4
|
6.136E-3
|
1.953E-2
|
3
|
179
|
21
|
HP:0010303
|
Abnormal spinal meningeal morphology
|
|
5.673E-5
|
9.487E-4
|
6.136E-3
|
2.048E-2
|
2
|
21
|
22
|
HP:0002637
|
Cerebral ischemia
|
|
5.977E-5
|
9.487E-4
|
6.136E-3
|
2.158E-2
|
3
|
185
|
23
|
HP:0005162
|
Left ventricular dysfunction
|
|
6.239E-5
|
9.487E-4
|
6.136E-3
|
2.252E-2
|
2
|
22
|
24
|
HP:0005116
|
Arterial tortuosity
|
|
6.833E-5
|
9.487E-4
|
6.136E-3
|
2.467E-2
|
2
|
23
|
25
|
HP:0012727
|
Thoracic aortic aneurysm
|
|
6.833E-5
|
9.487E-4
|
6.136E-3
|
2.467E-2
|
2
|
23
|
26
|
HP:0002631
|
Dilatation of ascending aorta
|
|
6.833E-5
|
9.487E-4
|
6.136E-3
|
2.467E-2
|
2
|
23
|
27
|
HP:0004948
|
Vascular tortuosity
|
|
8.773E-5
|
1.173E-3
|
7.586E-3
|
3.167E-2
|
2
|
26
|
28
|
HP:0009145
|
Abnormal cerebral artery morphology
|
|
9.403E-5
|
1.212E-3
|
7.841E-3
|
3.395E-2
|
3
|
215
|
29
|
HP:0004950
|
Peripheral arterial stenosis
|
|
1.096E-4
|
1.364E-3
|
8.820E-3
|
3.955E-2
|
2
|
29
|
30
|
HP:0004953
|
Dilatation of abdominal aorta
|
|
1.513E-4
|
1.820E-3
|
1.177E-2
|
5.461E-2
|
2
|
34
|
31
|
HP:0100545
|
Arterial stenosis
|
|
1.686E-4
|
1.902E-3
|
1.230E-2
|
6.088E-2
|
3
|
261
|
32
|
HP:0005114
|
Abnormalities of the peripheral arteries
|
|
1.686E-4
|
1.902E-3
|
1.230E-2
|
6.088E-2
|
3
|
261
|
33
|
HP:0011106
|
Hypovolemia
|
|
2.319E-4
|
2.508E-3
|
1.622E-2
|
8.371E-2
|
2
|
42
|
34
|
HP:0005112
|
Abdominal aortic aneurysm
|
|
2.432E-4
|
2.508E-3
|
1.622E-2
|
8.778E-2
|
2
|
43
|
35
|
HP:0011104
|
Abnormality of blood volume homeostasis
|
|
2.432E-4
|
2.508E-3
|
1.622E-2
|
8.778E-2
|
2
|
43
|
36
|
HP:0001933
|
Subcutaneous hemorrhage
|
|
2.539E-4
|
2.546E-3
|
1.647E-2
|
9.166E-2
|
3
|
299
|
37
|
HP:0005120
|
Abnormal cardiac atrium morphology
|
|
2.643E-4
|
2.578E-3
|
1.668E-2
|
9.540E-2
|
3
|
303
|
38
|
HP:0000577
|
Exotropia
|
|
3.706E-4
|
3.520E-3
|
2.277E-2
|
1.338E-1
|
2
|
53
|
39
|
HP:0002647
|
Aortic dissection
|
|
4.442E-4
|
4.112E-3
|
2.659E-2
|
1.604E-1
|
2
|
58
|
40
|
HP:0001297
|
Stroke
|
|
4.627E-4
|
4.176E-3
|
2.701E-2
|
1.671E-1
|
3
|
365
|
41
|
HP:0005344
|
Abnormal carotid artery morphology
|
|
4.755E-4
|
4.187E-3
|
2.708E-2
|
1.717E-1
|
2
|
60
|
42
|
HP:0005111
|
Dilatation of the ascending aorta
|
|
5.079E-4
|
4.365E-3
|
2.823E-2
|
1.833E-1
|
2
|
62
|
43
|
HP:0011029
|
Internal hemorrhage
|
|
5.348E-4
|
4.490E-3
|
2.904E-2
|
1.931E-1
|
3
|
383
|
44
|
HP:0006830
|
Severe neonatal hypotonia in males
|
|
6.373E-4
|
5.229E-3
|
3.382E-2
|
2.301E-1
|
1
|
1
|
45
|
HP:0000592
|
Blue sclerae
|
|
7.241E-4
|
5.809E-3
|
3.757E-2
|
2.614E-1
|
2
|
74
|
46
|
HP:0004942
|
Aortic aneurysm
|
|
7.841E-4
|
6.154E-3
|
3.980E-2
|
2.831E-1
|
2
|
77
|
47
|
HP:0001647
|
Bicuspid aortic valve
|
|
8.678E-4
|
6.393E-3
|
4.135E-2
|
3.133E-1
|
2
|
81
|
48
|
HP:0031567
|
Abnormal aortic valve cusp morphology
|
|
8.678E-4
|
6.393E-3
|
4.135E-2
|
3.133E-1
|
2
|
81
|
49
|
HP:0001659
|
Aortic regurgitation
|
|
8.678E-4
|
6.393E-3
|
4.135E-2
|
3.133E-1
|
2
|
81
|
50
|
HP:0001634
|
Mitral valve prolapse
|
|
9.782E-4
|
6.916E-3
|
4.473E-2
|
3.531E-1
|
2
|
86
|
Show 45 more annotations
|
5: Mouse Phenotype [Display Chart]
6 input genes in category / 281 annotations before applied cutoff / 10355 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
MP:0001719
|
absent vitelline blood vessels
|
|
7.782E-6
|
2.157E-3
|
1.341E-2
|
2.187E-3
|
3
|
77
|
2
|
MP:0005243
|
hemothorax
|
|
1.535E-5
|
2.157E-3
|
1.341E-2
|
4.314E-3
|
2
|
11
|
3
|
MP:0010856
|
dilated respiratory conducting tubes
|
|
6.430E-5
|
6.023E-3
|
3.745E-2
|
1.807E-2
|
2
|
22
|
4
|
MP:0003229
|
abnormal vitelline vasculature morphology
|
|
2.335E-4
|
1.641E-2
|
1.020E-1
|
6.562E-2
|
3
|
240
|
5
|
MP:0004178
|
neck telangiectases
|
|
5.794E-4
|
2.035E-2
|
1.265E-1
|
1.628E-1
|
1
|
1
|
6
|
MP:0004177
|
tail telangiectases
|
|
5.794E-4
|
2.035E-2
|
1.265E-1
|
1.628E-1
|
1
|
1
|
7
|
MP:0003609
|
small scrotum
|
|
5.794E-4
|
2.035E-2
|
1.265E-1
|
1.628E-1
|
1
|
1
|
8
|
MP:0004176
|
ear telangiectases
|
|
5.794E-4
|
2.035E-2
|
1.265E-1
|
1.628E-1
|
1
|
1
|
9
|
MP:0001634
|
internal hemorrhage
|
|
6.920E-4
|
2.161E-2
|
1.343E-1
|
1.944E-1
|
3
|
347
|
10
|
MP:0002295
|
abnormal pulmonary circulation
|
|
8.883E-4
|
2.459E-2
|
1.529E-1
|
2.496E-1
|
2
|
81
|
11
|
MP:0010531
|
gastrointestinal arteriovenous malformation
|
|
1.159E-3
|
2.459E-2
|
1.529E-1
|
3.256E-1
|
1
|
2
|
12
|
MP:0000260
|
abnormal angiogenesis
|
|
1.251E-3
|
2.459E-2
|
1.529E-1
|
3.517E-1
|
3
|
425
|
13
|
MP:0004391
|
abnormal respiratory conducting tube morphology
|
|
1.350E-3
|
2.459E-2
|
1.529E-1
|
3.795E-1
|
2
|
100
|
14
|
MP:0001429
|
dehydration
|
|
1.350E-3
|
2.459E-2
|
1.529E-1
|
3.795E-1
|
2
|
100
|
15
|
MP:0004950
|
abnormal brain vasculature morphology
|
|
1.350E-3
|
2.459E-2
|
1.529E-1
|
3.795E-1
|
2
|
100
|
16
|
MP:0014012
|
abnormal cranial blood vasculature morphology
|
|
1.432E-3
|
2.459E-2
|
1.529E-1
|
4.024E-1
|
2
|
103
|
17
|
MP:0005592
|
abnormal vascular smooth muscle morphology
|
|
1.488E-3
|
2.459E-2
|
1.529E-1
|
4.180E-1
|
2
|
105
|
18
|
MP:0003641
|
small lung
|
|
1.970E-3
|
3.012E-2
|
1.873E-1
|
5.536E-1
|
2
|
121
|
19
|
MP:0009889
|
persistence of medial edge epithelium during palatal shelf fusion
|
|
2.316E-3
|
3.012E-2
|
1.873E-1
|
6.508E-1
|
1
|
4
|
20
|
MP:0013139
|
moribund
|
|
2.316E-3
|
3.012E-2
|
1.873E-1
|
6.508E-1
|
1
|
4
|
21
|
MP:0005312
|
pericardial effusion
|
|
2.590E-3
|
3.012E-2
|
1.873E-1
|
7.279E-1
|
2
|
139
|
22
|
MP:0011575
|
dilated aorta bulb
|
|
2.894E-3
|
3.012E-2
|
1.873E-1
|
8.133E-1
|
1
|
5
|
23
|
MP:0012732
|
abnormal perineural vascular plexus morphology
|
|
2.894E-3
|
3.012E-2
|
1.873E-1
|
8.133E-1
|
1
|
5
|
24
|
MP:0003752
|
increased oral papilloma incidence
|
|
2.894E-3
|
3.012E-2
|
1.873E-1
|
8.133E-1
|
1
|
5
|
25
|
MP:0010530
|
cerebral arteriovenous malformation
|
|
2.894E-3
|
3.012E-2
|
1.873E-1
|
8.133E-1
|
1
|
5
|
26
|
MP:0000265
|
atretic vasculature
|
|
2.894E-3
|
3.012E-2
|
1.873E-1
|
8.133E-1
|
1
|
5
|
27
|
MP:0030356
|
premature lambdoid suture closure
|
|
2.894E-3
|
3.012E-2
|
1.873E-1
|
8.133E-1
|
1
|
5
|
28
|
MP:0012501
|
abnormal pericardial cavity morphology
|
|
3.089E-3
|
3.100E-2
|
1.927E-1
|
8.680E-1
|
2
|
152
|
29
|
MP:0000767
|
abnormal smooth muscle morphology
|
|
3.210E-3
|
3.110E-2
|
1.934E-1
|
9.020E-1
|
2
|
155
|
30
|
MP:0030350
|
premature coronal suture closure
|
|
3.472E-3
|
3.252E-2
|
2.022E-1
|
9.757E-1
|
1
|
6
|
31
|
MP:0001176
|
abnormal lung development
|
|
3.673E-3
|
3.329E-2
|
2.070E-1
|
1.000E0
|
2
|
166
|
32
|
MP:0004175
|
telangiectases
|
|
4.050E-3
|
3.347E-2
|
2.081E-1
|
1.000E0
|
1
|
7
|
33
|
MP:0005299
|
abnormal eye posterior chamber morphology
|
|
4.050E-3
|
3.347E-2
|
2.081E-1
|
1.000E0
|
1
|
7
|
34
|
MP:0002669
|
abnormal scrotum morphology
|
|
4.050E-3
|
3.347E-2
|
2.081E-1
|
1.000E0
|
1
|
7
|
35
|
MP:0004881
|
abnormal lung size
|
|
4.590E-3
|
3.514E-2
|
2.185E-1
|
1.000E0
|
2
|
186
|
36
|
MP:0010949
|
decreased Clara cell number
|
|
4.628E-3
|
3.514E-2
|
2.185E-1
|
1.000E0
|
1
|
8
|
37
|
MP:0011902
|
increased hematopoietic stem cell proliferation
|
|
4.628E-3
|
3.514E-2
|
2.185E-1
|
1.000E0
|
1
|
8
|
38
|
MP:0003115
|
abnormal respiratory system development
|
|
4.835E-3
|
3.575E-2
|
2.223E-1
|
1.000E0
|
2
|
191
|
39
|
MP:0005023
|
abnormal wound healing
|
|
5.446E-3
|
3.924E-2
|
2.440E-1
|
1.000E0
|
2
|
203
|
40
|
MP:0030006
|
decreased retinal apoptosis
|
|
5.782E-3
|
3.963E-2
|
2.464E-1
|
1.000E0
|
1
|
10
|
41
|
MP:0010661
|
ascending aorta aneurysm
|
|
5.782E-3
|
3.963E-2
|
2.464E-1
|
1.000E0
|
1
|
10
|
42
|
MP:0002052
|
decreased tumor incidence
|
|
6.147E-3
|
4.113E-2
|
2.557E-1
|
1.000E0
|
2
|
216
|
43
|
MP:0002270
|
abnormal pulmonary alveolus morphology
|
|
6.484E-3
|
4.188E-2
|
2.604E-1
|
1.000E0
|
2
|
222
|
44
|
MP:0000164
|
abnormal cartilage development
|
|
6.656E-3
|
4.188E-2
|
2.604E-1
|
1.000E0
|
2
|
225
|
45
|
MP:0010658
|
thoracic aorta aneurysm
|
|
6.935E-3
|
4.188E-2
|
2.604E-1
|
1.000E0
|
1
|
12
|
46
|
MP:0009874
|
abnormal interdigital cell death
|
|
6.935E-3
|
4.188E-2
|
2.604E-1
|
1.000E0
|
1
|
12
|
47
|
MP:0001718
|
abnormal visceral yolk sac morphology
|
|
7.005E-3
|
4.188E-2
|
2.604E-1
|
1.000E0
|
2
|
231
|
48
|
MP:0002726
|
abnormal pulmonary vein morphology
|
|
7.511E-3
|
4.221E-2
|
2.624E-1
|
1.000E0
|
1
|
13
|
49
|
MP:0004044
|
aortic dissection
|
|
7.511E-3
|
4.221E-2
|
2.624E-1
|
1.000E0
|
1
|
13
|
50
|
MP:0010996
|
increased aorta wall thickness
|
|
7.511E-3
|
4.221E-2
|
2.624E-1
|
1.000E0
|
1
|
13
|
Show 45 more annotations
|
6: Domain [Display Chart]
7 input genes in category / 81 annotations before applied cutoff / 18735 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
IPR015618
|
TGFB3
|
InterPro
|
3.736E-4
|
9.308E-3
|
4.633E-2
|
3.026E-2
|
1
|
1
|
2
|
2.60.40.1150
|
-
|
Gene3D
|
7.471E-4
|
9.308E-3
|
4.633E-2
|
6.052E-2
|
1
|
2
|
3
|
IPR013037
|
Clathrin b-adaptin app Ig-like
|
InterPro
|
7.471E-4
|
9.308E-3
|
4.633E-2
|
6.052E-2
|
1
|
2
|
4
|
IPR016342
|
AP complex bsu 1 2 4
|
InterPro
|
1.121E-3
|
9.308E-3
|
4.633E-2
|
9.076E-2
|
1
|
3
|
5
|
PF09066
|
B2-adapt-app C
|
Pfam
|
1.121E-3
|
9.308E-3
|
4.633E-2
|
9.076E-2
|
1
|
3
|
6
|
IPR019805
|
Heat shock protein 90 CS
|
InterPro
|
1.121E-3
|
9.308E-3
|
4.633E-2
|
9.076E-2
|
1
|
3
|
7
|
IPR016319
|
TGF-beta
|
InterPro
|
1.121E-3
|
9.308E-3
|
4.633E-2
|
9.076E-2
|
1
|
3
|
8
|
IPR020575
|
Hsp90 N
|
InterPro
|
1.494E-3
|
9.308E-3
|
4.633E-2
|
1.210E-1
|
1
|
4
|
9
|
SM01020
|
B2-adapt-app C
|
SMART
|
1.494E-3
|
9.308E-3
|
4.633E-2
|
1.210E-1
|
1
|
4
|
10
|
IPR015151
|
B-adaptin app sub C
|
InterPro
|
1.494E-3
|
9.308E-3
|
4.633E-2
|
1.210E-1
|
1
|
4
|
11
|
PF00183
|
HSP90
|
Pfam
|
1.494E-3
|
9.308E-3
|
4.633E-2
|
1.210E-1
|
1
|
4
|
12
|
PS00298
|
HSP90
|
PROSITE
|
1.494E-3
|
9.308E-3
|
4.633E-2
|
1.210E-1
|
1
|
4
|
13
|
IPR001404
|
Hsp90 fam
|
InterPro
|
1.494E-3
|
9.308E-3
|
4.633E-2
|
1.210E-1
|
1
|
4
|
14
|
IPR026739
|
AP beta
|
InterPro
|
1.867E-3
|
1.058E-2
|
5.268E-2
|
1.512E-1
|
1
|
5
|
15
|
3.30.310.10
|
-
|
Gene3D
|
2.240E-3
|
1.058E-2
|
5.268E-2
|
1.814E-1
|
1
|
6
|
16
|
IPR012295
|
Beta2 adaptin/TBP C dom
|
InterPro
|
2.240E-3
|
1.058E-2
|
5.268E-2
|
1.814E-1
|
1
|
6
|
17
|
PS51256
|
GS
|
PROSITE
|
2.613E-3
|
1.058E-2
|
5.268E-2
|
2.116E-1
|
1
|
7
|
18
|
IPR003605
|
GS dom
|
InterPro
|
2.613E-3
|
1.058E-2
|
5.268E-2
|
2.116E-1
|
1
|
7
|
19
|
PF08515
|
TGF beta GS
|
Pfam
|
2.613E-3
|
1.058E-2
|
5.268E-2
|
2.116E-1
|
1
|
7
|
20
|
SM00467
|
GS
|
SMART
|
2.613E-3
|
1.058E-2
|
5.268E-2
|
2.116E-1
|
1
|
7
|
21
|
IPR009028
|
Coatomer/calthrin app sub C
|
InterPro
|
2.986E-3
|
1.133E-2
|
5.642E-2
|
2.418E-1
|
1
|
8
|
22
|
IPR008152
|
Clathrin a/b/g-adaptin app Ig
|
InterPro
|
3.358E-3
|
1.133E-2
|
5.642E-2
|
2.720E-1
|
1
|
9
|
23
|
SM00809
|
Alpha adaptinC2
|
SMART
|
3.358E-3
|
1.133E-2
|
5.642E-2
|
2.720E-1
|
1
|
9
|
24
|
PF02883
|
Alpha adaptinC2
|
Pfam
|
3.358E-3
|
1.133E-2
|
5.642E-2
|
2.720E-1
|
1
|
9
|
25
|
IPR000472
|
Activin recp
|
InterPro
|
3.731E-3
|
1.162E-2
|
5.786E-2
|
3.022E-1
|
1
|
10
|
26
|
PF01064
|
Activin recp
|
Pfam
|
3.731E-3
|
1.162E-2
|
5.786E-2
|
3.022E-1
|
1
|
10
|
27
|
IPR013041
|
Coatomer/clathrin app Ig-like
|
InterPro
|
4.476E-3
|
1.295E-2
|
6.445E-2
|
3.625E-1
|
1
|
12
|
28
|
IPR000333
|
TGFB receptor
|
InterPro
|
4.476E-3
|
1.295E-2
|
6.445E-2
|
3.625E-1
|
1
|
12
|
29
|
PF01602
|
Adaptin N
|
Pfam
|
5.592E-3
|
1.466E-2
|
7.299E-2
|
4.529E-1
|
1
|
15
|
30
|
IPR002553
|
Clathrin/coatomer adapt-like N
|
InterPro
|
5.592E-3
|
1.466E-2
|
7.299E-2
|
4.529E-1
|
1
|
15
|
31
|
IPR001507
|
ZP dom
|
InterPro
|
6.335E-3
|
1.466E-2
|
7.299E-2
|
5.132E-1
|
1
|
17
|
32
|
PF00100
|
Zona pellucida
|
Pfam
|
6.335E-3
|
1.466E-2
|
7.299E-2
|
5.132E-1
|
1
|
17
|
33
|
PF02984
|
Cyclin C
|
Pfam
|
6.335E-3
|
1.466E-2
|
7.299E-2
|
5.132E-1
|
1
|
17
|
34
|
IPR004367
|
Cyclin C-dom
|
InterPro
|
6.335E-3
|
1.466E-2
|
7.299E-2
|
5.132E-1
|
1
|
17
|
35
|
SM01332
|
Cyclin C
|
SMART
|
6.335E-3
|
1.466E-2
|
7.299E-2
|
5.132E-1
|
1
|
17
|
36
|
SM00387
|
HATPase c
|
SMART
|
6.707E-3
|
1.509E-2
|
7.512E-2
|
5.433E-1
|
1
|
18
|
37
|
PF02518
|
HATPase c
|
Pfam
|
7.079E-3
|
1.550E-2
|
7.714E-2
|
5.734E-1
|
1
|
19
|
38
|
3.30.565.10
|
-
|
Gene3D
|
7.821E-3
|
1.667E-2
|
8.299E-2
|
6.335E-1
|
1
|
21
|
39
|
IPR003594
|
HATPase C
|
InterPro
|
8.192E-3
|
1.701E-2
|
8.470E-2
|
6.636E-1
|
1
|
22
|
40
|
PS00292
|
CYCLINS
|
PROSITE
|
1.042E-2
|
2.009E-2
|
1.000E-1
|
8.437E-1
|
1
|
28
|
41
|
IPR001111
|
TGF-b N
|
InterPro
|
1.042E-2
|
2.009E-2
|
1.000E-1
|
8.437E-1
|
1
|
28
|
42
|
PF00688
|
TGFb propeptide
|
Pfam
|
1.042E-2
|
2.009E-2
|
1.000E-1
|
8.437E-1
|
1
|
28
|
43
|
IPR015615
|
TGF-beta-rel
|
InterPro
|
1.190E-2
|
2.141E-2
|
1.066E-1
|
9.637E-1
|
1
|
32
|
44
|
IPR017948
|
TGFb CS
|
InterPro
|
1.190E-2
|
2.141E-2
|
1.066E-1
|
9.637E-1
|
1
|
32
|
45
|
PF00134
|
Cyclin N
|
Pfam
|
1.227E-2
|
2.141E-2
|
1.066E-1
|
9.936E-1
|
1
|
33
|
46
|
IPR006671
|
Cyclin N
|
InterPro
|
1.227E-2
|
2.141E-2
|
1.066E-1
|
9.936E-1
|
1
|
33
|
47
|
IPR020568
|
Ribosomal S5 D2-typ fold
|
InterPro
|
1.301E-2
|
2.141E-2
|
1.066E-1
|
1.000E0
|
1
|
35
|
48
|
PS00250
|
TGF BETA 1
|
PROSITE
|
1.374E-2
|
2.141E-2
|
1.066E-1
|
1.000E0
|
1
|
37
|
49
|
IPR001839
|
TGF-b C
|
InterPro
|
1.374E-2
|
2.141E-2
|
1.066E-1
|
1.000E0
|
1
|
37
|
50
|
PF00019
|
TGF beta
|
Pfam
|
1.374E-2
|
2.141E-2
|
1.066E-1
|
1.000E0
|
1
|
37
|
Show 45 more annotations
|
7: Pathway [Display Chart]
7 input genes in category / 208 annotations before applied cutoff / 12450 genes in category
|
8: Pubmed [Display Chart]
7 input genes in category / 2867 annotations before applied cutoff / 38193 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
1326540
|
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
|
Pubmed
|
3.769E-11
|
1.081E-7
|
9.227E-7
|
1.081E-7
|
3
|
5
|
2
|
9872992
|
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
|
Pubmed
|
6.216E-10
|
5.940E-7
|
5.072E-6
|
1.782E-6
|
3
|
11
|
3
|
17168649
|
A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.
|
Pubmed
|
6.216E-10
|
5.940E-7
|
5.072E-6
|
1.782E-6
|
3
|
11
|
4
|
22560297
|
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
|
Pubmed
|
1.222E-8
|
8.755E-6
|
7.476E-5
|
3.502E-5
|
4
|
167
|
5
|
29065449
|
Chronic Venous Insufficiency: Transforming Growth Factor-β Isoforms and Soluble Endoglin Concentration in Different States of Wound Healing.
|
Pubmed
|
2.879E-8
|
1.179E-5
|
1.007E-4
|
8.255E-5
|
2
|
2
|
6
|
18257072
|
Tissue-specific expression of Cre recombinase from the Tgfb3 locus.
|
Pubmed
|
2.879E-8
|
1.179E-5
|
1.007E-4
|
8.255E-5
|
2
|
2
|
7
|
18156205
|
Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3.
|
Pubmed
|
2.879E-8
|
1.179E-5
|
1.007E-4
|
8.255E-5
|
2
|
2
|
8
|
10433915
|
Pathogenesis of cleft palate in TGF-beta3 knockout mice.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
9
|
11850637
|
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
10
|
21423151
|
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
11
|
21465483
|
Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
12
|
12429842
|
Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
13
|
18243111
|
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
14
|
21170488
|
The role of the TGF-β coreceptor endoglin in cancer.
|
Pubmed
|
8.637E-8
|
1.681E-5
|
1.436E-4
|
2.476E-4
|
2
|
3
|
15
|
15342483
|
TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.
|
Pubmed
|
8.796E-8
|
1.681E-5
|
1.436E-4
|
2.522E-4
|
3
|
53
|
16
|
22848678
|
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation.
|
Pubmed
|
1.727E-7
|
2.358E-5
|
2.014E-4
|
4.952E-4
|
2
|
4
|
17
|
28633389
|
Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling.
|
Pubmed
|
1.727E-7
|
2.358E-5
|
2.014E-4
|
4.952E-4
|
2
|
4
|
18
|
23548068
|
Variation in endoglin pathway genes is associated with preeclampsia: a case-control candidate gene association study.
|
Pubmed
|
1.727E-7
|
2.358E-5
|
2.014E-4
|
4.952E-4
|
2
|
4
|
19
|
18974388
|
S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology.
|
Pubmed
|
1.727E-7
|
2.358E-5
|
2.014E-4
|
4.952E-4
|
2
|
4
|
20
|
23103542
|
Differential response of epithelial stem cell populations in hair follicles to TGF-β signaling.
|
Pubmed
|
1.727E-7
|
2.358E-5
|
2.014E-4
|
4.952E-4
|
2
|
4
|
21
|
28662367
|
Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis.
|
Pubmed
|
1.727E-7
|
2.358E-5
|
2.014E-4
|
4.952E-4
|
2
|
4
|
22
|
18591668
|
Critical regulation of TGFbeta signaling by Hsp90.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
23
|
12607775
|
Transforming growth factors beta1, beta2 and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
24
|
1333888
|
TGF beta signals through a heteromeric protein kinase receptor complex.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
25
|
12838410
|
Reduced programmed cell death in the retina and defects in lens and cornea of Tgfbeta2(-/-) Tgfbeta3(-/-) double-deficient mice.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
26
|
20856203
|
Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
27
|
12060054
|
Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
28
|
15702480
|
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
29
|
12015308
|
Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II.
|
Pubmed
|
2.879E-7
|
2.846E-5
|
2.430E-4
|
8.253E-4
|
2
|
5
|
30
|
19299629
|
Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
31
|
11157754
|
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
32
|
15020715
|
HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
33
|
9856985
|
Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
34
|
20042635
|
ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
35
|
19736306
|
Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
36
|
20301312
|
Loeys-Dietz Syndrome
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
37
|
26680585
|
ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
38
|
7852346
|
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
39
|
24474796
|
Thymocyte apoptosis drives the intrathymic generation of regulatory T cells.
|
Pubmed
|
4.318E-7
|
3.174E-5
|
2.710E-4
|
1.238E-3
|
2
|
6
|
40
|
17634193
|
Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction.
|
Pubmed
|
6.044E-7
|
3.851E-5
|
3.288E-4
|
1.733E-3
|
2
|
7
|
41
|
10757800
|
STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.
|
Pubmed
|
6.044E-7
|
3.851E-5
|
3.288E-4
|
1.733E-3
|
2
|
7
|
42
|
15761148
|
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.
|
Pubmed
|
6.044E-7
|
3.851E-5
|
3.288E-4
|
1.733E-3
|
2
|
7
|
43
|
24760528
|
Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-β expression in the lungs of female BALB/c mice.
|
Pubmed
|
6.044E-7
|
3.851E-5
|
3.288E-4
|
1.733E-3
|
2
|
7
|
44
|
19757385
|
TGFbeta3 is expressed in differentiating muscle of the embryonic mouse tongue.
|
Pubmed
|
6.044E-7
|
3.851E-5
|
3.288E-4
|
1.733E-3
|
2
|
7
|
45
|
18945958
|
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.
|
Pubmed
|
6.044E-7
|
3.851E-5
|
3.288E-4
|
1.733E-3
|
2
|
7
|
46
|
20603020
|
TGF-beta signaling specifies axons during brain development.
|
Pubmed
|
8.058E-7
|
4.915E-5
|
4.197E-4
|
2.310E-3
|
2
|
8
|
47
|
23868260
|
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
|
Pubmed
|
8.058E-7
|
4.915E-5
|
4.197E-4
|
2.310E-3
|
2
|
8
|
48
|
14729481
|
Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.
|
Pubmed
|
1.036E-6
|
6.188E-5
|
5.283E-4
|
2.970E-3
|
2
|
9
|
49
|
20346356
|
TGFbeta signaling in male germ cells regulates gonocyte quiescence and fertility in mice.
|
Pubmed
|
1.295E-6
|
7.139E-5
|
6.095E-4
|
3.712E-3
|
2
|
10
|
50
|
17314099
|
NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.
|
Pubmed
|
1.295E-6
|
7.139E-5
|
6.095E-4
|
3.712E-3
|
2
|
10
|
Show 45 more annotations
|
9: Interaction [Display Chart]
7 input genes in category / 1158 annotations before applied cutoff / 17703 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
int:TGFBR2
|
TGFBR2 interactions
|
|
1.967E-16
|
2.278E-13
|
1.739E-12
|
2.278E-13
|
7
|
104
|
2
|
int:TGFBR1
|
TGFBR1 interactions
|
|
1.298E-11
|
7.514E-9
|
5.735E-8
|
1.503E-8
|
6
|
199
|
3
|
int:ACVRL1
|
ACVRL1 interactions
|
|
1.079E-10
|
4.166E-8
|
3.179E-7
|
1.250E-7
|
4
|
25
|
4
|
int:TGFB3
|
TGFB3 interactions
|
|
1.719E-8
|
4.977E-6
|
3.798E-5
|
1.991E-5
|
3
|
15
|
5
|
int:ENG
|
ENG interactions
|
|
3.081E-8
|
7.061E-6
|
5.389E-5
|
3.568E-5
|
3
|
18
|
6
|
int:TGFB2
|
TGFB2 interactions
|
|
3.658E-8
|
7.061E-6
|
5.389E-5
|
4.236E-5
|
3
|
19
|
7
|
int:KLHL1
|
KLHL1 interactions
|
|
2.009E-6
|
2.908E-4
|
2.219E-3
|
2.326E-3
|
2
|
6
|
8
|
int:AMHR2
|
AMHR2 interactions
|
|
2.009E-6
|
2.908E-4
|
2.219E-3
|
2.326E-3
|
2
|
6
|
9
|
int:ACVR1
|
ACVR1 interactions
|
|
4.683E-6
|
6.025E-4
|
4.599E-3
|
5.423E-3
|
3
|
92
|
10
|
int:ENC1
|
ENC1 interactions
|
|
1.604E-5
|
1.691E-3
|
1.291E-2
|
1.857E-2
|
2
|
16
|
11
|
int:EPHA2
|
EPHA2 interactions
|
|
1.801E-5
|
1.691E-3
|
1.291E-2
|
2.086E-2
|
3
|
144
|
12
|
int:PPP6C
|
PPP6C interactions
|
|
1.995E-5
|
1.691E-3
|
1.291E-2
|
2.310E-2
|
3
|
149
|
13
|
int:FBXO34
|
FBXO34 interactions
|
|
2.044E-5
|
1.691E-3
|
1.291E-2
|
2.367E-2
|
2
|
18
|
14
|
int:TSSK1B
|
TSSK1B interactions
|
|
2.044E-5
|
1.691E-3
|
1.291E-2
|
2.367E-2
|
2
|
18
|
15
|
int:STK35
|
STK35 interactions
|
|
2.804E-5
|
2.165E-3
|
1.652E-2
|
3.248E-2
|
2
|
21
|
16
|
int:NUAK2
|
NUAK2 interactions
|
|
3.377E-5
|
2.444E-3
|
1.866E-2
|
3.911E-2
|
2
|
23
|
17
|
int:PREB
|
PREB interactions
|
|
4.682E-5
|
3.189E-3
|
2.434E-2
|
5.422E-2
|
2
|
27
|
18
|
int:LARP4B
|
LARP4B interactions
|
|
5.041E-5
|
3.243E-3
|
2.475E-2
|
5.838E-2
|
2
|
28
|
19
|
int:CDK14
|
CDK14 interactions
|
|
5.799E-5
|
3.535E-3
|
2.698E-2
|
6.716E-2
|
2
|
30
|
20
|
int:TGFBR3
|
TGFBR3 interactions
|
|
6.610E-5
|
3.827E-3
|
2.921E-2
|
7.654E-2
|
2
|
32
|
21
|
int:NEK8
|
NEK8 interactions
|
|
7.474E-5
|
4.121E-3
|
3.145E-2
|
8.654E-2
|
2
|
34
|
22
|
int:CKS2
|
CKS2 interactions
|
|
8.390E-5
|
4.416E-3
|
3.370E-2
|
9.715E-2
|
2
|
36
|
23
|
int:FBXL12
|
FBXL12 interactions
|
|
1.201E-4
|
6.046E-3
|
4.615E-2
|
1.391E-1
|
2
|
43
|
24
|
int:ITK
|
ITK interactions
|
|
1.376E-4
|
6.638E-3
|
5.066E-2
|
1.593E-1
|
2
|
46
|
25
|
int:SMAD6
|
SMAD6 interactions
|
|
1.829E-4
|
8.459E-3
|
6.456E-2
|
2.118E-1
|
2
|
53
|
26
|
int:CKS1B
|
CKS1B interactions
|
|
1.899E-4
|
8.459E-3
|
6.456E-2
|
2.199E-1
|
2
|
54
|
27
|
int:ACVR2B
|
ACVR2B interactions
|
|
2.043E-4
|
8.762E-3
|
6.688E-2
|
2.366E-1
|
2
|
56
|
28
|
int:SCRIB
|
SCRIB interactions
|
|
3.195E-4
|
1.322E-2
|
1.009E-1
|
3.700E-1
|
2
|
70
|
29
|
int:BMPR2
|
BMPR2 interactions
|
|
3.381E-4
|
1.350E-2
|
1.030E-1
|
3.915E-1
|
2
|
72
|
30
|
int:SMURF1
|
SMURF1 interactions
|
|
3.913E-4
|
1.482E-2
|
1.131E-1
|
4.531E-1
|
3
|
406
|
31
|
int:PDPK1
|
PDPK1 interactions
|
|
3.967E-4
|
1.482E-2
|
1.131E-1
|
4.594E-1
|
2
|
78
|
32
|
int:CDK7
|
CDK7 interactions
|
|
4.934E-4
|
1.786E-2
|
1.363E-1
|
5.714E-1
|
2
|
87
|
33
|
int:DAB2
|
DAB2 interactions
|
|
5.163E-4
|
1.798E-2
|
1.372E-1
|
5.979E-1
|
2
|
89
|
34
|
int:TTC1
|
TTC1 interactions
|
|
5.279E-4
|
1.798E-2
|
1.372E-1
|
6.113E-1
|
2
|
90
|
35
|
int:VCAM1
|
VCAM1 interactions
|
|
5.501E-4
|
1.820E-2
|
1.389E-1
|
6.370E-1
|
3
|
456
|
36
|
int:RPAP3
|
RPAP3 interactions
|
|
5.880E-4
|
1.891E-2
|
1.444E-1
|
6.809E-1
|
2
|
95
|
37
|
int:TAB2
|
TAB2 interactions
|
|
6.643E-4
|
2.079E-2
|
1.587E-1
|
7.693E-1
|
2
|
101
|
38
|
int:SMAD7
|
SMAD7 interactions
|
|
7.591E-4
|
2.081E-2
|
1.588E-1
|
8.790E-1
|
2
|
108
|
39
|
int:STRAP
|
STRAP interactions
|
|
7.591E-4
|
2.081E-2
|
1.588E-1
|
8.790E-1
|
2
|
108
|
40
|
int:TRIM73
|
TRIM73 interactions
|
|
7.907E-4
|
2.081E-2
|
1.588E-1
|
9.156E-1
|
1
|
2
|
41
|
int:RRH
|
RRH interactions
|
|
7.907E-4
|
2.081E-2
|
1.588E-1
|
9.156E-1
|
1
|
2
|
42
|
int:STYK1
|
STYK1 interactions
|
|
7.907E-4
|
2.081E-2
|
1.588E-1
|
9.156E-1
|
1
|
2
|
43
|
int:ISX
|
ISX interactions
|
|
7.907E-4
|
2.081E-2
|
1.588E-1
|
9.156E-1
|
1
|
2
|
44
|
int:STK32B
|
STK32B interactions
|
|
7.907E-4
|
2.081E-2
|
1.588E-1
|
9.156E-1
|
1
|
2
|
45
|
int:CDC25C
|
CDC25C interactions
|
|
8.305E-4
|
2.137E-2
|
1.631E-1
|
9.618E-1
|
2
|
113
|
46
|
int:BMPR1A
|
BMPR1A interactions
|
|
8.900E-4
|
2.230E-2
|
1.702E-1
|
1.000E0
|
2
|
117
|
47
|
int:SOCS6
|
SOCS6 interactions
|
|
9.051E-4
|
2.230E-2
|
1.702E-1
|
1.000E0
|
2
|
118
|
48
|
int:AP2B1
|
AP2B1 interactions
|
|
9.514E-4
|
2.289E-2
|
1.747E-1
|
1.000E0
|
2
|
121
|
49
|
int:PAK1
|
PAK1 interactions
|
|
9.829E-4
|
2.289E-2
|
1.747E-1
|
1.000E0
|
2
|
123
|
50
|
int:ATR
|
ATR interactions
|
|
9.988E-4
|
2.289E-2
|
1.747E-1
|
1.000E0
|
2
|
124
|
Show 45 more annotations
|
10: Cytoband [Display Chart]
7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
17q11.2-q12
|
17q11.2-q12
|
|
1.413E-3
|
7.769E-3
|
2.014E-2
|
9.891E-3
|
1
|
7
|
2
|
14q24
|
14q24
|
|
2.220E-3
|
7.769E-3
|
2.014E-2
|
1.554E-2
|
1
|
11
|
3
|
9q22
|
9q22
|
|
3.831E-3
|
8.939E-3
|
2.318E-2
|
2.682E-2
|
1
|
19
|
4
|
12p12.3
|
12p12.3
|
|
6.445E-3
|
9.023E-3
|
2.340E-2
|
4.512E-2
|
1
|
32
|
5
|
15q22.2
|
15q22.2
|
|
6.445E-3
|
9.023E-3
|
2.340E-2
|
4.512E-2
|
1
|
32
|
6
|
9q34.11
|
9q34.11
|
|
1.186E-2
|
1.383E-2
|
3.586E-2
|
8.299E-2
|
1
|
59
|
7
|
14q32.33
|
14q32.33
|
|
4.728E-2
|
4.728E-2
|
1.226E-1
|
3.310E-1
|
1
|
239
|
Show 2 more annotations
|
11: Transcription Factor Binding Site [Display Chart]
5 input genes in category / 75 annotations before applied cutoff / 9770 genes in category
|
12: Gene Family [Display Chart]
6 input genes in category / 6 annotations before applied cutoff / 18194 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
586
|
Heat shock 90kDa proteins
|
genenames.org
|
1.648E-3
|
6.920E-3
|
1.695E-2
|
9.888E-3
|
1
|
5
|
2
|
345
|
Type 1 receptor serine/threonine kinases|CD molecules
|
genenames.org
|
2.307E-3
|
6.920E-3
|
1.695E-2
|
1.384E-2
|
1
|
7
|
3
|
473
|
Cyclins
|
genenames.org
|
9.527E-3
|
1.905E-2
|
4.668E-2
|
5.716E-2
|
1
|
29
|
|
13: Coexpression [Display Chart]
7 input genes in category / 1235 annotations before applied cutoff / 23137 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
M4011
|
Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.858E-7
|
2.295E-4
|
1.766E-3
|
2.295E-4
|
4
|
200
|
2
|
16585153-Table1
|
Mouse Skin Hagendoorn06 54genes
|
GeneSigDB
|
3.724E-7
|
2.299E-4
|
1.770E-3
|
4.599E-4
|
3
|
52
|
3
|
15073102-Table1d
|
Human Breast Glinsky04 14genes survival
|
GeneSigDB
|
4.310E-6
|
1.277E-3
|
9.830E-3
|
5.323E-3
|
2
|
11
|
4
|
15073102-Table1c
|
Human Breast Glinsky04 12genes survival
|
GeneSigDB
|
4.310E-6
|
1.277E-3
|
9.830E-3
|
5.323E-3
|
2
|
11
|
5
|
M208
|
Genes up-regulated in DLD-1 cells (colon cancer) in response to hypoxia; might not be direct targets of HIF1A [GeneID=3091].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
5.171E-6
|
1.277E-3
|
9.830E-3
|
6.386E-3
|
2
|
12
|
6
|
M12112
|
Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.221E-5
|
2.486E-3
|
1.913E-2
|
1.507E-2
|
3
|
165
|
7
|
M11701
|
Selected genes up-regulated during invasion of lymphatic vessels during metastasis.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.487E-5
|
2.486E-3
|
1.913E-2
|
1.836E-2
|
2
|
20
|
8
|
11823860-SuppTable2
|
Human Breast van'tVeer02 231genes PoorPrognosisSignature
|
GeneSigDB
|
1.610E-5
|
2.486E-3
|
1.913E-2
|
1.989E-2
|
3
|
181
|
9
|
M5431
|
Genes down-regulated in comparison of mast cells versus macrophages.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
2.139E-5
|
2.935E-3
|
2.259E-2
|
2.641E-2
|
3
|
199
|
10
|
20156340-GENIUS-ERposHER2neg signature
|
Human Breast HaibeKains10 229genes GENIUS ERposHER2neg
|
GeneSigDB
|
2.886E-5
|
3.240E-3
|
2.494E-2
|
3.564E-2
|
3
|
220
|
11
|
18698033-tableS1-AURKA
|
Human Breast Desmedt08 229genes AURKA Module
|
GeneSigDB
|
2.886E-5
|
3.240E-3
|
2.494E-2
|
3.564E-2
|
3
|
220
|
12
|
17295094-GeneList
|
Human Breast VandenEynden07 269genes-hypoxia angiogenesis
|
GeneSigDB
|
4.914E-5
|
5.057E-3
|
3.892E-2
|
6.068E-2
|
3
|
263
|
13
|
M1249
|
Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.717E-5
|
6.213E-3
|
4.782E-2
|
8.295E-2
|
2
|
42
|
14
|
18778486-TableS3
|
Human Breast Karlsson08 46genes
|
GeneSigDB
|
7.043E-5
|
6.213E-3
|
4.782E-2
|
8.698E-2
|
2
|
43
|
15
|
11823860-Figure2
|
Human Breast van'tVeer02 70genes Mammaprint
|
GeneSigDB
|
1.073E-4
|
7.149E-3
|
5.503E-2
|
1.325E-1
|
2
|
53
|
16
|
18794116-Table1
|
Mouse Lymphoma Clasper08 56genes
|
GeneSigDB
|
1.114E-4
|
7.149E-3
|
5.503E-2
|
1.376E-1
|
2
|
54
|
17
|
M5896
|
Genes up-regulated in response to TGFB1 [GeneID=7040].
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
1.114E-4
|
7.149E-3
|
5.503E-2
|
1.376E-1
|
2
|
54
|
18
|
M14693
|
The optimal set of 70 prognostic markers predicting poor breast cancer clinical outcome (defined as developing metastases with 5 years).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.156E-4
|
7.149E-3
|
5.503E-2
|
1.428E-1
|
2
|
55
|
19
|
17069664-SuppTable2
|
Human Breast Nuyten06 70genes hypoxia
|
GeneSigDB
|
1.156E-4
|
7.149E-3
|
5.503E-2
|
1.428E-1
|
2
|
55
|
20
|
M500
|
Genes whose expression is significantly and positively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.199E-4
|
7.149E-3
|
5.503E-2
|
1.481E-1
|
2
|
56
|
21
|
17210682-Table2b
|
Human Colon Grade07 101genes
|
GeneSigDB
|
1.287E-4
|
7.149E-3
|
5.503E-2
|
1.589E-1
|
2
|
58
|
22
|
17899371-GeneTable4
|
Human Breast Lauss08 374genes
|
GeneSigDB
|
1.290E-4
|
7.149E-3
|
5.503E-2
|
1.593E-1
|
3
|
364
|
23
|
20165955-Table2
|
Human Liver Simon10 81genes
|
GeneSigDB
|
1.331E-4
|
7.149E-3
|
5.503E-2
|
1.644E-1
|
2
|
59
|
24
|
M3274
|
Top up-regulated marker genes for medulloblastoma classification: desmoplastic vs classic morphology.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.471E-4
|
7.569E-3
|
5.826E-2
|
1.817E-1
|
2
|
62
|
25
|
16533762-Table1
|
Human Uterine Matsumura06 67genes
|
GeneSigDB
|
1.668E-4
|
8.238E-3
|
6.340E-2
|
2.059E-1
|
2
|
66
|
26
|
16513839-Table3
|
Human Prostate Nanni06 70genes
|
GeneSigDB
|
1.770E-4
|
8.409E-3
|
6.472E-2
|
2.186E-1
|
2
|
68
|
27
|
M170
|
Genes down-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.154E-4
|
9.767E-3
|
7.517E-2
|
2.661E-1
|
2
|
75
|
28
|
16488994-SuppTable1b
|
Mouse Lung Lu06 856genes Array MEO430Av2
|
GeneSigDB
|
2.304E-4
|
9.767E-3
|
7.517E-2
|
2.846E-1
|
3
|
443
|
29
|
19699293-TableS3
|
Human Breast Bienkowska09 103genes
|
GeneSigDB
|
2.391E-4
|
9.767E-3
|
7.517E-2
|
2.953E-1
|
2
|
79
|
30
|
16488994-SuppTable1a
|
Mouse Lung Lu06 856genes Array MG U74Av2
|
GeneSigDB
|
2.398E-4
|
9.767E-3
|
7.517E-2
|
2.961E-1
|
3
|
449
|
31
|
M1395
|
Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Pre-BI stage.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.452E-4
|
9.767E-3
|
7.517E-2
|
3.028E-1
|
2
|
80
|
32
|
17284527-Table2
|
Human Lypmhoma Leval07 96genes
|
GeneSigDB
|
2.703E-4
|
1.043E-2
|
8.029E-2
|
3.338E-1
|
2
|
84
|
33
|
18199535-SuppTable3
|
Human StemCell Amundson08 138genes
|
GeneSigDB
|
6.069E-4
|
2.210E-2
|
1.701E-1
|
7.496E-1
|
2
|
126
|
34
|
16611997-Table2
|
Mouse StemCell Affar06 131genes
|
GeneSigDB
|
6.166E-4
|
2.210E-2
|
1.701E-1
|
7.614E-1
|
2
|
127
|
35
|
M13537
|
Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.262E-4
|
2.210E-2
|
1.701E-1
|
7.734E-1
|
2
|
128
|
36
|
M2902
|
Genes up-regulated in epithelial prostate cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene.
|
MSigDB C6: Oncogenic Signatures (v6.0)
|
7.484E-4
|
2.534E-2
|
1.950E-1
|
9.242E-1
|
2
|
140
|
37
|
18427120-DataS5
|
Human Breast Crawford08 187genes
|
GeneSigDB
|
7.590E-4
|
2.534E-2
|
1.950E-1
|
9.374E-1
|
2
|
141
|
38
|
M11513
|
Genes down-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
9.043E-4
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
154
|
39
|
M13108
|
Genes down-regulated in Wilm's tumor samples compared to fetal kidney.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.012E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
163
|
40
|
M8949
|
Genes up-regulated in T conv cells from aged PPARG [GeneID=5468] knockout: visceral adipose tissue versus lymph node.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.024E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
164
|
41
|
M6817
|
Genes up-regulated in dendritic cells: untreated versus anti-FcgRIIB.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.100E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
170
|
42
|
20368555-TS-2
|
Human Breast Barry10 205genes
|
GeneSigDB
|
1.178E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
176
|
43
|
M3456
|
Genes identified by ChIP within the high-affinity group of MYC [GeneID=4609] targets.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.259E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
182
|
44
|
M2812
|
Genes down-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi.
|
MSigDB C6: Oncogenic Signatures (v6.0)
|
1.329E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
187
|
45
|
M7943
|
Genes up-regulated in macrophages (12h): IFNG, TNF [GeneID=3458;7124] and rosiglitazone [PubChem=77999] versus rosiglitazone [PubChem=77999] and IL4 [GeneID=3565].
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.429E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
194
|
46
|
M5491
|
Genes up-regulated in comparison of macrophages versus neutrophils.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.502E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
199
|
47
|
M8274
|
Genes down-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.502E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
199
|
48
|
M8444
|
Genes down-regulated in lung innate lymphoid cells versus spleen CD4 [GeneID=920] T cells.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.502E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
199
|
49
|
M3701
|
Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with LPS (TLR4 agonist) at 12 h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.502E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
2
|
199
|
50
|
12606954-table1c
|
Human Prostate Bigler03 6genes
|
GeneSigDB
|
1.512E-3
|
2.677E-2
|
2.060E-1
|
1.000E0
|
1
|
5
|
Show 45 more annotations
|
14: Coexpression Atlas [Display Chart]
7 input genes in category / 1245 annotations before applied cutoff / 21829 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-A
|
Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-A
|
Lungmap CCHMC
|
8.132E-5
|
2.476E-2
|
1.908E-1
|
1.012E-1
|
3
|
294
|
2
|
Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D
|
Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D
|
Lungmap CCHMC
|
8.465E-5
|
2.476E-2
|
1.908E-1
|
1.054E-1
|
3
|
298
|
3
|
GSM605778 500
|
gamma delta T cells, Tgd.vg1+vd6+.Th.TCRbko, TCRd+ Vg1.1+ Vd6.3+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.125E-4
|
2.476E-2
|
1.908E-1
|
1.401E-1
|
3
|
328
|
4
|
GSM476675 500
|
gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.352E-4
|
2.476E-2
|
1.908E-1
|
1.683E-1
|
3
|
349
|
5
|
GSM605784 500
|
gamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.519E-4
|
2.476E-2
|
1.908E-1
|
1.891E-1
|
3
|
363
|
6
|
GSM605781 500
|
gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.646E-4
|
2.476E-2
|
1.908E-1
|
2.049E-1
|
3
|
373
|
7
|
10X Human 8K PBMC unknown Subtype unknown-unknown Top 200 Genes
|
10X Human 8K PBMC unknown Subtype unknown-unknown Top 200 Genes
|
|
1.780E-4
|
2.476E-2
|
1.908E-1
|
2.216E-1
|
3
|
383
|
8
|
GSM605799 500
|
gamma delta T cells, Tgd.vg2-24ahi.Th.TCRbko, TCRd+ Vg2- CD24+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.964E-4
|
2.476E-2
|
1.908E-1
|
2.446E-1
|
3
|
396
|
9
|
GSM605793 500
|
gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.208E-4
|
2.476E-2
|
1.908E-1
|
2.749E-1
|
3
|
412
|
10
|
Lungmap Mouse Lung E16.5 Myofibroblast Subtype Migrating Myofibroblast
|
Lungmap Mouse Lung E16.5 Myofibroblast Subtype Migrating Myofibroblast
|
Lungmap CCHMC
|
2.288E-4
|
2.476E-2
|
1.908E-1
|
2.849E-1
|
3
|
417
|
11
|
GSM476658 500
|
gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2
|
Immgen.org, GSE15907
|
2.370E-4
|
2.476E-2
|
1.908E-1
|
2.950E-1
|
3
|
422
|
12
|
GSM476655 500
|
gamma delta T cells, Tgd.vg2+24ahi.Th, TCRd+ Vg2+ CD24+, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.386E-4
|
2.476E-2
|
1.908E-1
|
2.971E-1
|
3
|
423
|
13
|
gudmap developingKidney e14.5 whole kidney - Wnt4 KO 200 k2
|
DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#2 top-relative-expression-ranked 200
|
Gudmap Mouse MOE430.2
|
2.892E-4
|
2.533E-2
|
1.951E-1
|
3.600E-1
|
2
|
82
|
14
|
GSM476675 100
|
gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3
|
Immgen.org, GSE15907
|
3.034E-4
|
2.533E-2
|
1.951E-1
|
3.778E-1
|
2
|
84
|
15
|
GSM605793 100
|
gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3
|
Immgen.org, GSE15907
|
3.107E-4
|
2.533E-2
|
1.951E-1
|
3.868E-1
|
2
|
85
|
16
|
GSM476655 100
|
gamma delta T cells, Tgd.vg2+24ahi.Th, TCRd+ Vg2+ CD24+, Thymus, avg-3
|
Immgen.org, GSE15907
|
3.255E-4
|
2.533E-2
|
1.951E-1
|
4.052E-1
|
2
|
87
|
17
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Synpr/Synpr,Pcdh11x
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Synpr/Synpr,Pcdh11x
|
BrainMap
|
4.828E-4
|
3.468E-2
|
2.672E-1
|
6.011E-1
|
2
|
106
|
18
|
Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT9
|
Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT9
|
Adult, Development, and Cancer types
|
5.198E-4
|
3.468E-2
|
2.672E-1
|
6.471E-1
|
2
|
110
|
19
|
Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Normal-Cortex Wilms T U
|
Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Normal-Cortex Wilms T U
|
Adult, Development, and Cancer types
|
5.292E-4
|
3.468E-2
|
2.672E-1
|
6.589E-1
|
2
|
111
|
Show 14 more annotations
|
15: Computational [Display Chart]
7 input genes in category / 86 annotations before applied cutoff / 10037 genes in category
|
16: MicroRNA [Display Chart]
7 input genes in category / 358 annotations before applied cutoff / 72241 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
hsa-miR-6826-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
9.785E-5
|
1.003E-2
|
6.477E-2
|
3.503E-2
|
2
|
157
|
2
|
hsa-miR-549:PITA
|
hsa-miR-549:PITA TOP
|
PITA
|
1.107E-4
|
1.003E-2
|
6.477E-2
|
3.963E-2
|
2
|
167
|
3
|
hsa-miR-642:PITA
|
hsa-miR-642:PITA TOP
|
PITA
|
1.107E-4
|
1.003E-2
|
6.477E-2
|
3.963E-2
|
2
|
167
|
4
|
hsa-miR-619:PITA
|
hsa-miR-619:PITA TOP
|
PITA
|
1.120E-4
|
1.003E-2
|
6.477E-2
|
4.011E-2
|
2
|
168
|
5
|
hsa-miR-140-5p:PITA
|
hsa-miR-140-5p:PITA TOP
|
PITA
|
3.170E-4
|
2.246E-2
|
1.451E-1
|
1.135E-1
|
2
|
283
|
6
|
hsa-miR-1271:PITA
|
hsa-miR-1271:PITA TOP
|
PITA
|
5.003E-4
|
2.246E-2
|
1.451E-1
|
1.791E-1
|
2
|
356
|
7
|
hsa-miR-96:PITA
|
hsa-miR-96:PITA TOP
|
PITA
|
5.059E-4
|
2.246E-2
|
1.451E-1
|
1.811E-1
|
2
|
358
|
8
|
hsa-miR-101-3p:Functional MTI
|
Functional MTI
|
miRTarbase
|
6.088E-4
|
2.246E-2
|
1.451E-1
|
2.180E-1
|
2
|
393
|
9
|
hsa-let-7f-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
6.212E-4
|
2.246E-2
|
1.451E-1
|
2.224E-1
|
2
|
397
|
10
|
hsa-miR-204-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
6.274E-4
|
2.246E-2
|
1.451E-1
|
2.246E-1
|
2
|
399
|
11
|
hsa-miR-10a-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
8.426E-4
|
2.332E-2
|
1.507E-1
|
3.017E-1
|
2
|
463
|
12
|
hsa-miR-1306:mirSVR lowEffct
|
hsa-miR-1306:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
8.426E-4
|
2.332E-2
|
1.507E-1
|
3.017E-1
|
2
|
463
|
13
|
hsa-miR-539:PITA
|
hsa-miR-539:PITA TOP
|
PITA
|
9.162E-4
|
2.332E-2
|
1.507E-1
|
3.280E-1
|
2
|
483
|
14
|
hsa-miR-425*:mirSVR lowEffct
|
hsa-miR-425*:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
9.695E-4
|
2.332E-2
|
1.507E-1
|
3.471E-1
|
2
|
497
|
15
|
hsa-miR-490-3p:mirSVR highEffct
|
hsa-miR-490-3p:mirSVR conserved highEffect-0.5
|
MicroRNA.org
|
9.773E-4
|
2.332E-2
|
1.507E-1
|
3.499E-1
|
2
|
499
|
16
|
hsa-miR-1306:PITA
|
hsa-miR-1306:PITA TOP
|
PITA
|
2.227E-3
|
3.835E-2
|
2.477E-1
|
7.971E-1
|
1
|
23
|
17
|
hsa-miR-6798-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.710E-3
|
3.835E-2
|
2.477E-1
|
9.702E-1
|
1
|
28
|
18
|
hsa-miR-656-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.807E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
29
|
19
|
hsa-miR-6755-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
3.193E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
33
|
20
|
hsa-miR-1298:PITA
|
hsa-miR-1298:PITA TOP
|
PITA
|
3.290E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
34
|
21
|
hsa-miR-1228-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.352E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
45
|
22
|
hsa-miR-342-5p:PITA
|
hsa-miR-342-5p:PITA TOP
|
PITA
|
4.449E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
46
|
23
|
hsa-miR-4703-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.739E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
49
|
24
|
hsa-miR-550a-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.739E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
49
|
25
|
hsa-miR-200c-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.835E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
50
|
26
|
hsa-miR-4781-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.835E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
50
|
27
|
hsa-miR-1278:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.932E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
51
|
28
|
hsa-miR-600:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.028E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
52
|
29
|
hsa-miR-8083:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.125E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
53
|
30
|
hsa-miR-500b-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.607E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
58
|
31
|
hsa-miR-1244:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.703E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
59
|
32
|
CCAGGTT,MIR-490:MSigDB
|
CCAGGTT,MIR-490:MSigDB
|
MSigDB
|
5.992E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
62
|
33
|
hsa-miR-219a-2-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.089E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
63
|
34
|
hsa-miR-362-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.089E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
63
|
35
|
hsa-miR-3156-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.185E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
64
|
36
|
hsa-miR-4679:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.667E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
69
|
37
|
hsa-miR-5590-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.860E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
71
|
38
|
CTCAAGA,MIR-526B:MSigDB
|
CTCAAGA,MIR-526B:MSigDB
|
MSigDB
|
6.956E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
72
|
39
|
hsa-miR-4677-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.149E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
74
|
40
|
hsa-miR-499b-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.149E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
74
|
41
|
hsa-miR-374a-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.245E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
75
|
42
|
hsa-miR-6815-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.341E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
76
|
43
|
hsa-miR-6865-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.438E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
77
|
44
|
hsa-miR-379:PITA
|
hsa-miR-379:PITA TOP
|
PITA
|
7.438E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
77
|
45
|
hsa-miR-4732-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.534E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
78
|
46
|
hsa-miR-3943:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.534E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
78
|
47
|
hsa-miR-3688-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.630E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
79
|
48
|
hsa-miR-3529-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
8.015E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
83
|
49
|
hsa-miR-135b-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
8.015E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
83
|
50
|
hsa-miR-769-5p:PITA
|
hsa-miR-769-5p:PITA TOP
|
PITA
|
8.015E-3
|
3.835E-2
|
2.477E-1
|
1.000E0
|
1
|
83
|
Show 45 more annotations
|
17: Drug [Display Chart]
7 input genes in category / 2030 annotations before applied cutoff / 22841 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
CID000005263
|
lysosphingomyelin
|
Stitch
|
1.178E-5
|
1.003E-2
|
8.221E-2
|
2.392E-2
|
3
|
161
|
2
|
2167 DN
|
Benzocaine [94-09-7]; Down 200; 24.2uM; HL60; HT HG-U133A
|
Broad Institute CMAP Down
|
2.222E-5
|
1.003E-2
|
8.221E-2
|
4.511E-2
|
3
|
199
|
3
|
ctd:C007350
|
nitrofen
|
CTD
|
3.791E-5
|
1.003E-2
|
8.221E-2
|
7.696E-2
|
3
|
238
|
4
|
CID000002384
|
AC1L1DK5
|
Stitch
|
3.976E-5
|
1.003E-2
|
8.221E-2
|
8.071E-2
|
2
|
32
|
5
|
ctd:D014800
|
Vitallium
|
CTD
|
4.083E-5
|
1.003E-2
|
8.221E-2
|
8.289E-2
|
3
|
244
|
6
|
CID000011178
|
zinc stearate
|
Stitch
|
6.245E-5
|
1.003E-2
|
8.221E-2
|
1.268E-1
|
2
|
40
|
7
|
CID000015625
|
dioxin
|
Stitch
|
1.163E-4
|
1.003E-2
|
8.221E-2
|
2.360E-1
|
3
|
347
|
8
|
CID000124013
|
Bouin's solution
|
Stitch
|
1.509E-4
|
1.003E-2
|
8.221E-2
|
3.064E-1
|
2
|
62
|
9
|
CID000079689
|
polyoxyethylene (10
|
Stitch
|
1.558E-4
|
1.003E-2
|
8.221E-2
|
3.164E-1
|
2
|
63
|
10
|
CID000005526
|
tranexamic acid
|
Stitch
|
1.608E-4
|
1.003E-2
|
8.221E-2
|
3.265E-1
|
2
|
64
|
11
|
ctd:C000621033
|
napabucasin
|
CTD
|
1.608E-4
|
1.003E-2
|
8.221E-2
|
3.265E-1
|
2
|
64
|
12
|
CID000005372
|
NSC717865
|
Stitch
|
1.618E-4
|
1.003E-2
|
8.221E-2
|
3.285E-1
|
3
|
388
|
13
|
CID009549240
|
3 tp
|
Stitch
|
1.711E-4
|
1.003E-2
|
8.221E-2
|
3.473E-1
|
2
|
66
|
14
|
CID000065947
|
prulifloxacin
|
Stitch
|
1.925E-4
|
1.003E-2
|
8.221E-2
|
3.908E-1
|
2
|
70
|
15
|
CID000005291
|
imatinib
|
Stitch
|
2.192E-4
|
1.003E-2
|
8.221E-2
|
4.450E-1
|
3
|
430
|
16
|
CID000015967
|
azar
|
Stitch
|
2.210E-4
|
1.003E-2
|
8.221E-2
|
4.487E-1
|
2
|
75
|
17
|
ctd:D003975
|
Diazepam
|
CTD
|
2.210E-4
|
1.003E-2
|
8.221E-2
|
4.487E-1
|
2
|
75
|
18
|
CID005282473
|
Zinostatino
|
Stitch
|
2.391E-4
|
1.003E-2
|
8.221E-2
|
4.854E-1
|
2
|
78
|
19
|
ctd:C064116
|
S-(1,1,2,2-tetrafluoroethyl)cysteine
|
CTD
|
2.391E-4
|
1.003E-2
|
8.221E-2
|
4.854E-1
|
2
|
78
|
20
|
ctd:C025340
|
manganese chloride
|
CTD
|
2.640E-4
|
1.003E-2
|
8.221E-2
|
5.359E-1
|
3
|
458
|
21
|
ctd:C084656
|
paricalcitol
|
CTD
|
3.043E-4
|
1.003E-2
|
8.221E-2
|
6.178E-1
|
2
|
88
|
22
|
DB03093
|
8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
23
|
DB08557
|
2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
24
|
DB07317
|
(3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
25
|
DB03899
|
9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
26
|
DB08787
|
4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
27
|
DB06964
|
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
28
|
DB03504
|
9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
29
|
DB06961
|
5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
30
|
DB08436
|
8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
31
|
DB07495
|
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
32
|
DB08442
|
4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
33
|
DB08789
|
2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
34
|
DB07601
|
4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
35
|
DB08443
|
2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
36
|
CID000122861
|
AC1L3VEN
|
Stitch
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
37
|
DB02550
|
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
38
|
DB02359
|
9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
39
|
DB07325
|
N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
40
|
DB08786
|
4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
41
|
DB03749
|
4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
42
|
DB03809
|
9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
43
|
DB06956
|
N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
44
|
DB02840
|
4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
45
|
DB07324
|
3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
46
|
DB07100
|
4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
47
|
CID000077692
|
2h PCA
|
Stitch
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
48
|
DB08194
|
4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
49
|
DB04505
|
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
50
|
DB07319
|
6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
|
Drug Bank
|
3.065E-4
|
1.003E-2
|
8.221E-2
|
6.221E-1
|
1
|
1
|
Show 45 more annotations
|
18: Disease [Display Chart]
7 input genes in category / 458 annotations before applied cutoff / 16205 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
C4022878
|
Descending aortic dissection
|
DisGeNET Curated
|
1.245E-5
|
9.500E-4
|
6.370E-3
|
5.701E-3
|
2
|
13
|
2
|
C1836653
|
Ascending aortic dissection
|
DisGeNET Curated
|
1.245E-5
|
9.500E-4
|
6.370E-3
|
5.701E-3
|
2
|
13
|
3
|
C2674574
|
Aortic aneurysm, familial thoracic 3
|
DisGeNET Curated
|
1.245E-5
|
9.500E-4
|
6.370E-3
|
5.701E-3
|
2
|
13
|
4
|
C1836635
|
Loeys-Dietz Aortic Aneurysm Syndrome
|
DisGeNET Curated
|
1.245E-5
|
9.500E-4
|
6.370E-3
|
5.701E-3
|
2
|
13
|
5
|
C0392775
|
Cystic medial necrosis of aorta
|
DisGeNET Curated
|
1.245E-5
|
9.500E-4
|
6.370E-3
|
5.701E-3
|
2
|
13
|
6
|
C4025845
|
Abnormality of the iris
|
DisGeNET Curated
|
1.452E-5
|
9.500E-4
|
6.370E-3
|
6.650E-3
|
2
|
14
|
7
|
C0013405
|
Dyspnea, Paroxysmal
|
DisGeNET Curated
|
1.452E-5
|
9.500E-4
|
6.370E-3
|
6.650E-3
|
2
|
14
|
8
|
C0553982
|
Impaired left ventricular function
|
DisGeNET Curated
|
1.914E-5
|
1.096E-3
|
7.347E-3
|
8.765E-3
|
2
|
16
|
9
|
C0023212
|
Left-Sided Heart Failure
|
DisGeNET Curated
|
2.726E-5
|
1.387E-3
|
9.300E-3
|
1.248E-2
|
2
|
19
|
10
|
C0231807
|
Dyspnea on exertion
|
DisGeNET Curated
|
4.395E-5
|
2.013E-3
|
1.350E-2
|
2.013E-2
|
2
|
24
|
11
|
C0266122
|
Cleft uvula
|
DisGeNET Curated
|
5.585E-5
|
2.326E-3
|
1.559E-2
|
2.558E-2
|
2
|
27
|
12
|
C0334533
|
Arteriovenous hemangioma
|
DisGeNET BeFree
|
7.885E-5
|
2.551E-3
|
1.711E-2
|
3.611E-2
|
2
|
32
|
13
|
C0542514
|
Blue sclera
|
DisGeNET Curated
|
8.392E-5
|
2.551E-3
|
1.711E-2
|
3.843E-2
|
2
|
33
|
14
|
C0241240
|
Tall stature
|
DisGeNET Curated
|
8.914E-5
|
2.551E-3
|
1.711E-2
|
4.083E-2
|
2
|
34
|
15
|
C0263401
|
Cutis marmorata
|
DisGeNET Curated
|
8.914E-5
|
2.551E-3
|
1.711E-2
|
4.083E-2
|
2
|
34
|
16
|
C0008479
|
Chondrosarcoma
|
DisGeNET Curated
|
9.470E-5
|
2.551E-3
|
1.711E-2
|
4.337E-2
|
3
|
230
|
17
|
C1282496
|
Metastasis from malignant tumor of prostate
|
DisGeNET BeFree
|
9.470E-5
|
2.551E-3
|
1.711E-2
|
4.337E-2
|
3
|
230
|
18
|
C0149630
|
Bicuspid aortic valve
|
DisGeNET Curated
|
1.058E-4
|
2.648E-3
|
1.775E-2
|
4.844E-2
|
2
|
37
|
19
|
C0003504
|
Aortic Valve Insufficiency
|
DisGeNET Curated
|
1.129E-4
|
2.648E-3
|
1.775E-2
|
5.169E-2
|
3
|
244
|
20
|
C0936223
|
Metastatic Prostate Carcinoma
|
DisGeNET BeFree
|
1.156E-4
|
2.648E-3
|
1.775E-2
|
5.296E-2
|
3
|
246
|
21
|
C0039446
|
Telangiectasis
|
DisGeNET Curated
|
1.238E-4
|
2.700E-3
|
1.810E-2
|
5.669E-2
|
2
|
40
|
22
|
C0856169
|
Endothelial dysfunction
|
DisGeNET BeFree
|
1.410E-4
|
2.934E-3
|
1.968E-2
|
6.456E-2
|
3
|
263
|
23
|
C0003706
|
Arachnodactyly
|
DisGeNET Curated
|
1.863E-4
|
3.710E-3
|
2.487E-2
|
8.532E-2
|
2
|
49
|
24
|
C0008031
|
Chest Pain
|
DisGeNET Curated
|
2.436E-4
|
4.038E-3
|
2.707E-2
|
1.116E-1
|
2
|
56
|
25
|
C0158646
|
Cleft palate with cleft lip
|
DisGeNET Curated
|
2.524E-4
|
4.038E-3
|
2.707E-2
|
1.156E-1
|
2
|
57
|
26
|
C0003857
|
Congenital arteriovenous malformation
|
DisGeNET Curated
|
2.892E-4
|
4.038E-3
|
2.707E-2
|
1.324E-1
|
2
|
61
|
27
|
C0011389
|
Dental Plaque
|
DisGeNET BeFree
|
2.892E-4
|
4.038E-3
|
2.707E-2
|
1.324E-1
|
2
|
61
|
28
|
C0042133
|
Uterine Fibroids
|
DisGeNET Curated
|
3.089E-4
|
4.038E-3
|
2.707E-2
|
1.415E-1
|
3
|
343
|
29
|
C0264133
|
Acquired flat foot
|
DisGeNET Curated
|
4.142E-4
|
4.038E-3
|
2.707E-2
|
1.897E-1
|
2
|
73
|
30
|
C0016202
|
Flatfoot
|
DisGeNET Curated
|
4.142E-4
|
4.038E-3
|
2.707E-2
|
1.897E-1
|
2
|
73
|
31
|
OMIN:107970
|
ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1; ARVD1
|
OMIM
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
32
|
C0033740
|
Protozoan Infections
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
33
|
C4083047
|
MULTIPLE SELF-HEALING SQUAMOUS EPITHELIOMA, SUSCEPTIBILITY TO
|
DisGeNET Curated
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
34
|
C0684550
|
Secondary malignant neoplasm of vertebral column
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
35
|
C0264969
|
Aneurysm of celiac artery
|
DisGeNET Curated
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
36
|
OMIN:187300
|
TELANGIECTASIA, HEREDITARY HEMORRHAGIC, OF RENDU, OSLER, AND WEBER; HHT
|
OMIM
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
37
|
C4225631
|
HEREDITARY HEMORRHAGIC TELANGIECTASIA 1
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
38
|
C4023119
|
Mesenteric artery aneurysm
|
DisGeNET Curated
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
39
|
C1857692
|
Venous varicosities of celiac and mesenteric vessels
|
DisGeNET Curated
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
40
|
C0276871
|
Infection by Trypanosoma evansi
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
41
|
C3825353
|
Protozoan diseases
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
42
|
C1862511
|
ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1 (disorder)
|
DisGeNET Curated
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
43
|
cv:C0039445
|
Osler hemorrhagic telangiectasia syndrome
|
Clinical Variations
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
44
|
cv:CN182633
|
Rienhoff syndrome
|
Clinical Variations
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
45
|
C0302883
|
SMITH DISEASE
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
46
|
C4086114
|
Canine Mammary Carcinoma
|
DisGeNET BeFree
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
47
|
C0742747
|
High-output congestive heart failure
|
DisGeNET Curated
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
48
|
cv:C1862511
|
Arrhythmogenic right ventricular cardiomyopathy, type 1
|
Clinical Variations
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
49
|
cv:C0546476
|
Multiple self healing squamous epithelioma
|
Clinical Variations
|
4.320E-4
|
4.038E-3
|
2.707E-2
|
1.978E-1
|
1
|
1
|
50
|
C0162810
|
Cicatrix, Hypertrophic
|
DisGeNET BeFree
|
4.490E-4
|
4.112E-3
|
2.757E-2
|
2.056E-1
|
2
|
76
|
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