|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
11877444
|
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.
|
Pubmed
|
2.939E-14
|
4.762E-11
|
3.794E-10
|
4.762E-11
|
5
|
20
|
2
|
9702189
|
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
|
Pubmed
|
1.015E-12
|
8.224E-10
|
6.553E-9
|
1.645E-9
|
4
|
9
|
3
|
21258344
|
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.
|
Pubmed
|
2.306E-12
|
1.245E-9
|
9.923E-9
|
3.736E-9
|
5
|
45
|
4
|
9139820
|
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
|
Pubmed
|
3.080E-11
|
1.248E-8
|
9.940E-8
|
4.990E-8
|
3
|
3
|
5
|
27773593
|
FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.
|
Pubmed
|
3.896E-11
|
1.262E-8
|
1.006E-7
|
6.312E-8
|
4
|
20
|
6
|
19596656
|
Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.
|
Pubmed
|
4.812E-11
|
1.299E-8
|
1.035E-7
|
7.795E-8
|
4
|
21
|
7
|
9139821
|
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
|
Pubmed
|
1.232E-10
|
2.851E-8
|
2.272E-7
|
1.996E-7
|
3
|
4
|
8
|
15729358
|
Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.
|
Pubmed
|
3.079E-10
|
6.235E-8
|
4.968E-7
|
4.988E-7
|
3
|
5
|
9
|
15604093
|
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
|
Pubmed
|
5.974E-10
|
9.974E-8
|
7.947E-7
|
9.678E-7
|
5
|
133
|
10
|
10640275
|
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
|
Pubmed
|
6.157E-10
|
9.974E-8
|
7.947E-7
|
9.974E-7
|
3
|
6
|
11
|
23770565
|
Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.
|
Pubmed
|
1.077E-9
|
1.454E-7
|
1.159E-6
|
1.745E-6
|
3
|
7
|
12
|
17956988
|
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
|
Pubmed
|
1.077E-9
|
1.454E-7
|
1.159E-6
|
1.745E-6
|
3
|
7
|
13
|
11430826
|
Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
|
Pubmed
|
1.723E-9
|
1.861E-7
|
1.483E-6
|
2.792E-6
|
3
|
8
|
14
|
20935208
|
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.
|
Pubmed
|
1.723E-9
|
1.861E-7
|
1.483E-6
|
2.792E-6
|
3
|
8
|
15
|
10049357
|
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.
|
Pubmed
|
1.723E-9
|
1.861E-7
|
1.483E-6
|
2.792E-6
|
3
|
8
|
16
|
10944117
|
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.
|
Pubmed
|
2.584E-9
|
2.204E-7
|
1.756E-6
|
4.187E-6
|
3
|
9
|
17
|
12007404
|
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.
|
Pubmed
|
2.584E-9
|
2.204E-7
|
1.756E-6
|
4.187E-6
|
3
|
9
|
18
|
19244234
|
Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1.
|
Pubmed
|
2.584E-9
|
2.204E-7
|
1.756E-6
|
4.187E-6
|
3
|
9
|
19
|
24821727
|
Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression.
|
Pubmed
|
2.584E-9
|
2.204E-7
|
1.756E-6
|
4.187E-6
|
3
|
9
|
20
|
11931768
|
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.
|
Pubmed
|
3.691E-9
|
2.848E-7
|
2.269E-6
|
5.980E-6
|
3
|
10
|
21
|
15001550
|
Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.
|
Pubmed
|
3.691E-9
|
2.848E-7
|
2.269E-6
|
5.980E-6
|
3
|
10
|
22
|
16469706
|
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
|
Pubmed
|
8.793E-9
|
6.474E-7
|
5.159E-6
|
1.424E-5
|
3
|
13
|
23
|
12590135
|
The histone deacetylase 9 gene encodes multiple protein isoforms.
|
Pubmed
|
1.119E-8
|
7.658E-7
|
6.102E-6
|
1.813E-5
|
3
|
14
|
24
|
28611094
|
Agonist-specific protein interactomes of glucocorticoid and androgen receptor as revealed by proximity mapping.
|
Pubmed
|
1.135E-8
|
7.658E-7
|
6.102E-6
|
1.838E-5
|
4
|
78
|
25
|
18660489
|
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
|
Pubmed
|
1.424E-8
|
9.225E-7
|
7.350E-6
|
2.306E-5
|
5
|
250
|
26
|
11102443
|
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
|
Pubmed
|
1.721E-8
|
1.032E-6
|
8.226E-6
|
2.787E-5
|
3
|
16
|
27
|
11013263
|
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.
|
Pubmed
|
1.721E-8
|
1.032E-6
|
8.226E-6
|
2.787E-5
|
3
|
16
|
28
|
23752268
|
The functional interactome landscape of the human histone deacetylase family.
|
Pubmed
|
2.835E-8
|
1.640E-6
|
1.307E-5
|
4.593E-5
|
5
|
287
|
29
|
15572661
|
Negative modulation of androgen receptor transcriptional activity by Daxx.
|
Pubmed
|
5.434E-8
|
2.934E-6
|
2.338E-5
|
8.803E-5
|
3
|
23
|
30
|
19737349
|
Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.
|
Pubmed
|
5.434E-8
|
2.934E-6
|
2.338E-5
|
8.803E-5
|
3
|
23
|
31
|
20956564
|
The mammalian Sin3 proteins are required for muscle development and sarcomere specification.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
32
|
19299558
|
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
33
|
27733359
|
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
34
|
10077563
|
Unique forms of human and mouse nuclear receptor corepressor SMRT.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
35
|
26166430
|
Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
36
|
22944139
|
Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
37
|
27780928
|
SIN3A and SIN3B differentially regulate breast cancer metastasis.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
38
|
21131350
|
Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.
|
Pubmed
|
1.069E-7
|
4.559E-6
|
3.633E-5
|
1.733E-4
|
2
|
2
|
39
|
26593974
|
Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
|
Pubmed
|
1.244E-7
|
5.167E-6
|
4.117E-5
|
2.015E-4
|
3
|
30
|
40
|
22476904
|
Sin3 interacts with Foxk1 and regulates myogenic progenitors.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
41
|
22337871
|
Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
42
|
10406466
|
The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
43
|
11113190
|
Oligomerization of ETO is obligatory for corepressor interaction.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
44
|
21518914
|
EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
45
|
12904255
|
ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
46
|
12011091
|
RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
47
|
18052923
|
The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
48
|
19098224
|
Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
49
|
22101514
|
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|
50
|
15016838
|
Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.
|
Pubmed
|
3.208E-7
|
8.808E-6
|
7.018E-5
|
5.197E-4
|
2
|
3
|