Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc91_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 48 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035258 steroid hormone receptor binding 1.657E-11 7.952E-10 3.546E-9 7.952E-10 6 89
2 GO:0035257 nuclear hormone receptor binding 6.131E-10 1.472E-8 6.561E-8 2.943E-8 6 161
3 GO:0046965 retinoid X receptor binding 1.028E-9 1.594E-8 7.105E-8 4.936E-8 4 22
4 GO:0051427 hormone receptor binding 1.328E-9 1.594E-8 7.105E-8 6.374E-8 6 183
5 GO:0003714 transcription corepressor activity 5.965E-9 5.726E-8 2.553E-7 2.863E-7 6 235
6 GO:0042974 retinoic acid receptor binding 3.474E-8 2.779E-7 1.239E-6 1.667E-6 4 51
7 GO:0035259 glucocorticoid receptor binding 2.543E-7 1.744E-6 7.775E-6 1.221E-5 3 19
8 GO:0016922 nuclear receptor binding 6.021E-7 3.613E-6 1.611E-5 2.890E-5 3 25
9 GO:0050681 androgen receptor binding 2.773E-6 1.400E-5 6.240E-5 1.331E-4 3 41
10 GO:0004407 histone deacetylase activity 2.985E-6 1.400E-5 6.240E-5 1.433E-4 3 42
11 GO:0033558 protein deacetylase activity 3.207E-6 1.400E-5 6.240E-5 1.540E-4 3 43
12 GO:0030331 estrogen receptor binding 4.207E-6 1.683E-5 7.504E-5 2.020E-4 3 47
13 GO:0019213 deacetylase activity 1.024E-5 3.780E-5 1.685E-4 4.914E-4 3 63
14 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.996E-5 1.027E-4 4.580E-4 1.438E-3 3 90
15 GO:0003713 transcription coactivator activity 4.745E-5 1.518E-4 6.770E-4 2.277E-3 4 310
16 GO:0042826 histone deacetylase binding 6.073E-5 1.822E-4 8.124E-4 2.915E-3 3 114
17 GO:0042975 peroxisome proliferator activated receptor binding 7.610E-5 2.149E-4 9.580E-4 3.653E-3 2 19
18 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.319E-4 3.517E-4 1.568E-3 6.331E-3 3 148
19 GO:0046966 thyroid hormone receptor binding 2.060E-4 5.203E-4 2.320E-3 9.886E-3 2 31
20 GO:0001102 RNA polymerase II activating transcription factor binding 3.105E-4 7.452E-4 3.323E-3 1.490E-2 2 38
21 GO:0033613 activating transcription factor binding 8.010E-4 1.831E-3 8.164E-3 3.845E-2 2 61
22 GO:0001078 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific 2.761E-3 6.025E-3 2.686E-2
1.325E-1
2 114
23 GO:0001085 RNA polymerase II transcription factor binding 2.955E-3 6.166E-3 2.750E-2
1.418E-1
2 118
24 GO:0035033 histone deacetylase regulator activity 3.479E-3 6.957E-3 3.102E-2
1.670E-1
1 5
25 GO:0001206 distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific 6.254E-3 1.155E-2
5.148E-2
3.002E-1
1 9
26 GO:0048495 Roundabout binding 6.254E-3 1.155E-2
5.148E-2
3.002E-1
1 9
27 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 6.875E-3 1.191E-2
5.309E-2
3.300E-1
2 182
28 GO:0008140 cAMP response element binding protein binding 6.946E-3 1.191E-2
5.309E-2
3.334E-1
1 10
29 GO:0070411 I-SMAD binding 7.638E-3 1.264E-2
5.637E-2
3.666E-1
1 11
30 GO:0005112 Notch binding 1.385E-2 2.216E-2
9.879E-2
6.647E-1
1 20
31 GO:0001103 RNA polymerase II repressing transcription factor binding 1.934E-2 2.994E-2
1.335E-1
9.282E-1
1 28
32 GO:0001205 distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific 2.071E-2 3.106E-2
1.385E-1
9.939E-1
1 30
33 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 2.581E-2 3.754E-2
1.674E-1
1.000E0
2 365
Show 28 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 434 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006476 protein deacetylation 5.020E-9 9.753E-7 6.487E-6 2.178E-6 5 100
2 GO:0035601 protein deacylation 6.426E-9 9.753E-7 6.487E-6 2.789E-6 5 105
3 GO:0098732 macromolecule deacylation 6.742E-9 9.753E-7 6.487E-6 2.926E-6 5 106
4 GO:0016575 histone deacetylation 3.076E-7 2.775E-5 1.845E-4 1.335E-4 4 87
5 GO:0009755 hormone-mediated signaling pathway 3.196E-7 2.775E-5 1.845E-4 1.387E-4 5 229
6 GO:0042593 glucose homeostasis 5.995E-7 3.717E-5 2.472E-4 2.602E-4 5 260
7 GO:0033500 carbohydrate homeostasis 5.995E-7 3.717E-5 2.472E-4 2.602E-4 5 260
8 GO:0030522 intracellular receptor signaling pathway 1.195E-6 6.483E-5 4.312E-4 5.186E-4 5 299
9 GO:0030518 intracellular steroid hormone receptor signaling pathway 1.849E-6 8.915E-5 5.930E-4 8.023E-4 4 136
10 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 6.737E-6 2.699E-4 1.795E-3 2.924E-3 2 6
11 GO:0043401 steroid hormone mediated signaling pathway 6.840E-6 2.699E-4 1.795E-3 2.969E-3 4 189
12 GO:0060968 regulation of gene silencing 7.608E-6 2.751E-4 1.830E-3 3.302E-3 3 57
13 GO:0016570 histone modification 8.552E-6 2.855E-4 1.899E-3 3.711E-3 5 447
14 GO:0016569 covalent chromatin modification 1.004E-5 3.112E-4 2.070E-3 4.357E-3 5 462
15 GO:0030521 androgen receptor signaling pathway 1.132E-5 3.275E-4 2.179E-3 4.913E-3 3 65
16 GO:0060965 negative regulation of gene silencing by miRNA 1.257E-5 3.408E-4 2.267E-3 5.453E-3 2 8
17 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 1.615E-5 4.123E-4 2.742E-3 7.009E-3 2 9
18 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2.018E-5 4.379E-4 2.913E-3 8.758E-3 2 10
19 GO:0060149 negative regulation of posttranscriptional gene silencing 2.018E-5 4.379E-4 2.913E-3 8.758E-3 2 10
20 GO:0060967 negative regulation of gene silencing by RNA 2.018E-5 4.379E-4 2.913E-3 8.758E-3 2 10
21 GO:0071383 cellular response to steroid hormone stimulus 3.686E-5 7.618E-4 5.067E-3 1.600E-2 4 290
22 GO:0060969 negative regulation of gene silencing 7.641E-5 1.507E-3 1.003E-2 3.316E-2 2 19
23 GO:0048511 rhythmic process 9.118E-5 1.721E-3 1.144E-2 3.957E-2 4 366
24 GO:0060964 regulation of gene silencing by miRNA 1.129E-4 1.959E-3 1.303E-2 4.899E-2 2 23
25 GO:0090312 positive regulation of protein deacetylation 1.129E-4 1.959E-3 1.303E-2 4.899E-2 2 23
26 GO:0060147 regulation of posttranscriptional gene silencing 1.448E-4 2.328E-3 1.548E-2
6.285E-2
2 26
27 GO:0060966 regulation of gene silencing by RNA 1.448E-4 2.328E-3 1.548E-2
6.285E-2
2 26
28 GO:0035196 production of miRNAs involved in gene silencing by miRNA 2.068E-4 3.190E-3 2.122E-2
8.975E-2
2 31
29 GO:0070918 production of small RNA involved in gene silencing by RNA 2.205E-4 3.190E-3 2.122E-2
9.569E-2
2 32
30 GO:0031050 dsRNA processing 2.205E-4 3.190E-3 2.122E-2
9.569E-2
2 32
31 GO:0090311 regulation of protein deacetylation 3.632E-4 5.085E-3 3.382E-2
1.576E-1
2 41
32 GO:0007623 circadian rhythm 3.930E-4 5.331E-3 3.546E-2
1.706E-1
3 214
33 GO:0071359 cellular response to dsRNA 5.193E-4 6.629E-3 4.409E-2
2.254E-1
2 49
34 GO:0045599 negative regulation of fat cell differentiation 5.193E-4 6.629E-3 4.409E-2
2.254E-1
2 49
35 GO:0008406 gonad development 6.261E-4 7.213E-3 4.798E-2
2.717E-1
3 251
36 GO:0035195 gene silencing by miRNA 6.542E-4 7.213E-3 4.798E-2
2.839E-1
2 55
37 GO:0016458 gene silencing 6.631E-4 7.213E-3 4.798E-2
2.878E-1
3 256
38 GO:0045137 development of primary sexual characteristics 6.631E-4 7.213E-3 4.798E-2
2.878E-1
3 256
39 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter 6.981E-4 7.213E-3 4.798E-2
3.030E-1
1 1
40 GO:1901675 negative regulation of histone H3-K27 acetylation 6.981E-4 7.213E-3 4.798E-2
3.030E-1
1 1
41 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter 6.981E-4 7.213E-3 4.798E-2
3.030E-1
1 1
42 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle 6.981E-4 7.213E-3 4.798E-2
3.030E-1
1 1
43 GO:0040029 regulation of gene expression, epigenetic 7.331E-4 7.258E-3 4.828E-2
3.182E-1
3 265
44 GO:0016441 posttranscriptional gene silencing 7.526E-4 7.258E-3 4.828E-2
3.266E-1
2 59
45 GO:0035194 posttranscriptional gene silencing by RNA 7.526E-4 7.258E-3 4.828E-2
3.266E-1
2 59
46 GO:0032922 circadian regulation of gene expression 8.308E-4 7.838E-3
5.213E-2
3.606E-1
2 62
47 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 8.850E-4 8.172E-3
5.436E-2
3.841E-1
2 64
48 GO:0043966 histone H3 acetylation 9.409E-4 8.507E-3
5.658E-2
4.083E-1
2 66
49 GO:0043620 regulation of DNA-templated transcription in response to stress 1.058E-3 9.368E-3
6.231E-2
4.590E-1
2 70
50 GO:0007548 sex differentiation 1.144E-3 9.926E-3
6.602E-2
4.963E-1
3 309
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 35 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000118 histone deacetylase complex 4.230E-10 1.480E-8 6.139E-8 1.480E-8 5 63
2 GO:0016580 Sin3 complex 8.982E-8 1.572E-6 6.518E-6 3.144E-6 3 14
3 GO:0070822 Sin3-type complex 1.676E-7 1.662E-6 6.891E-6 5.866E-6 3 17
4 GO:0017053 transcriptional repressor complex 1.899E-7 1.662E-6 6.891E-6 6.647E-6 4 79
5 GO:0000790 nuclear chromatin 1.583E-6 1.108E-5 4.596E-5 5.542E-5 5 324
6 GO:0000785 chromatin 1.159E-5 6.758E-5 2.802E-4 4.055E-4 5 487
7 GO:0005667 transcription factor complex 8.514E-5 4.257E-4 1.765E-3 2.980E-3 4 368
8 GO:0030849 autosome 1.364E-3 5.303E-3 2.199E-2 4.773E-2 1 2
9 GO:0000806 Y chromosome 1.364E-3 5.303E-3 2.199E-2 4.773E-2 1 2
10 GO:0016363 nuclear matrix 2.253E-3 7.887E-3 3.271E-2
7.887E-2
2 105
11 GO:0034399 nuclear periphery 3.690E-3 1.174E-2 4.869E-2
1.292E-1
2 135
12 GO:0000805 X chromosome 5.444E-3 1.588E-2
6.585E-2
1.905E-1
1 8
13 GO:0001741 XY body 1.154E-2 3.106E-2
1.288E-1
4.038E-1
1 17
Show 8 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 221 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 11 input genes in category / 338 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 13 input genes in category / 71 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF15784 GPS2 interact Pfam 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
2 IPR013194 HDAC interact dom InterPro 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
3 SM00761 HDAC interact SMART 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
4 IPR031557 N-CoR GPS2 interact InterPro 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
5 PF08295 Sin3 corepress Pfam 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
6 IPR031693 Sin3 C InterPro 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
7 PF16879 Sin3a C Pfam 4.445E-7 4.508E-6 2.185E-5 3.156E-5 2 2
8 IPR017884 SANT dom InterPro 6.724E-7 5.967E-6 2.892E-5 4.774E-5 3 26
9 PS51293 SANT PROSITE 8.465E-7 6.678E-6 3.237E-5 6.010E-5 3 28
10 1.20.1160.11 - Gene3D 1.333E-6 7.280E-6 3.528E-5 9.463E-5 2 3
11 PF02671 PAH Pfam 1.333E-6 7.280E-6 3.528E-5 9.463E-5 2 3
12 PS51477 PAH PROSITE 1.333E-6 7.280E-6 3.528E-5 9.463E-5 2 3
13 IPR003822 PAH InterPro 1.333E-6 7.280E-6 3.528E-5 9.463E-5 2 3
14 PF00249 Myb DNA-binding Pfam 1.686E-6 8.553E-6 4.145E-5 1.197E-4 3 35
15 PS50090 MYB LIKE PROSITE 2.171E-6 1.028E-5 4.981E-5 1.541E-4 3 38
16 SM00717 SANT SMART 5.020E-6 2.228E-5 1.080E-4 3.564E-4 3 50
17 IPR001005 SANT/Myb InterPro 5.656E-6 2.362E-5 1.145E-4 4.016E-4 3 52
18 PF15690 NRIP1 repr 4 Pfam 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
19 IPR026638 NCOA6 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
20 PF12489 ARA70 Pfam 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
21 IPR022174 ARA70 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
22 PF15688 NRIP1 repr 2 Pfam 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
23 IPR032715 NCOA6 nucleic acid-bd InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
24 IPR031408 NRIP1 RD4 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
25 IPR026649 NRIP1 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
26 IPR031407 NRIP1 RD3 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
27 PF15687 NRIP1 repr 1 Pfam 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
28 PF15689 NRIP1 repr 3 Pfam 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
29 IPR031405 NRIP1 RD1 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
30 IPR031406 NRIP1 RD2 InterPro 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
31 PF13820 Nucleic acid bd Pfam 6.939E-4 1.589E-3 7.703E-3 4.927E-2 1 1
32 1.10.10.60 - Gene3D 8.718E-4 1.934E-3 9.375E-3
6.190E-2
3 283
33 IPR009057 Homeodomain-like InterPro 1.382E-3 2.736E-3 1.326E-2
9.814E-2
3 332
34 1.20.5.370 - Gene3D 1.387E-3 2.736E-3 1.326E-2
9.850E-2
1 2
35 IPR017305 Tgfb1i1/Leupaxin InterPro 1.387E-3 2.736E-3 1.326E-2
9.850E-2
1 2
36 IPR014751 XRCC4 C InterPro 1.387E-3 2.736E-3 1.326E-2
9.850E-2
1 2
37 IPR024786 TORC InterPro 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
38 IPR024783 TORC N InterPro 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
39 IPR024785 TORC C InterPro 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
40 PF12884 TORC N Pfam 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
41 PF12886 TORC C Pfam 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
42 PF12885 TORC M Pfam 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
43 IPR024784 TORC M InterPro 2.080E-3 3.435E-3 1.665E-2
1.477E-1
1 3
44 PS50097 BTB PROSITE 5.315E-3 8.576E-3 4.157E-2
3.773E-1
2 160
45 SM00225 BTB SMART 6.679E-3 1.054E-2
5.107E-2
4.742E-1
2 180
46 IPR000210 BTB/POZ dom InterPro 7.042E-3 1.087E-2
5.268E-2
5.000E-1
2 185
47 IPR011333 SKP1/BTB/POZ InterPro 7.339E-3 1.109E-2
5.374E-2
5.211E-1
2 189
48 3.40.50.800 - Gene3D 7.608E-3 1.125E-2
5.455E-2
5.402E-1
1 11
49 SM01189 ELM2 SMART 8.986E-3 1.181E-2
5.727E-2
6.380E-1
1 13
50 PF03131 bZIP Maf Pfam 8.986E-3 1.181E-2
5.727E-2
6.380E-1
1 13
Show 45 more annotations

7: Pathway [Display Chart] 11 input genes in category / 78 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270029 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BioSystems: REACTOME 4.489E-8 3.502E-6 1.730E-5 3.502E-6 5 127
2 138085 Coregulation of Androgen receptor activity BioSystems: Pathway Interaction Database 1.272E-7 4.961E-6 2.451E-5 9.922E-6 4 57
3 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 2.311E-7 6.010E-6 2.969E-5 1.803E-5 4 66
4 1269871 Circadian Clock BioSystems: REACTOME 3.109E-7 6.063E-6 2.995E-5 2.425E-5 4 71
5 M14449 METS affect on Macrophage Differentiation MSigDB C2 BIOCARTA (v6.0) 4.157E-7 6.485E-6 3.204E-5 3.242E-5 3 18
6 1270010 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 1.393E-6 1.811E-5 8.945E-5 1.086E-4 5 253
7 1269873 RORA activates gene expression BioSystems: REACTOME 1.661E-6 1.851E-5 9.143E-5 1.295E-4 3 28
8 P00029 Huntington disease PantherDB 2.838E-6 2.767E-5 1.367E-4 2.213E-4 4 123
9 1268841 Transcriptional activation of mitochondrial biogenesis BioSystems: REACTOME 7.135E-6 6.184E-5 3.055E-4 5.566E-4 3 45
10 1269872 BMAL1:CLOCK,NPAS2 activates circadian gene expression BioSystems: REACTOME 8.685E-6 6.774E-5 3.347E-4 6.774E-4 3 48
11 1268839 Mitochondrial biogenesis BioSystems: REACTOME 1.242E-5 8.806E-5 4.350E-4 9.686E-4 3 54
12 M2404 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) MSigDB C2 BIOCARTA (v6.0) 1.542E-5 1.002E-4 4.951E-4 1.203E-3 3 58
13 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 3.622E-5 2.173E-4 1.074E-3 2.825E-3 3 77
14 1270345 Transcriptional regulation of white adipocyte differentiation BioSystems: REACTOME 5.405E-5 3.011E-4 1.488E-3 4.216E-3 3 88
15 1270436 HDACs deacetylate histones BioSystems: REACTOME 6.583E-5 3.423E-4 1.691E-3 5.134E-3 3 94
16 1269529 Downregulation of SMAD2/3:SMAD4 transcriptional activity BioSystems: REACTOME 1.778E-4 8.665E-4 4.281E-3 1.386E-2 2 23
17 138039 Retinoic acid receptors-mediated signaling BioSystems: Pathway Interaction Database 2.106E-4 9.661E-4 4.773E-3 1.642E-2 2 25
18 M2499 CARM1 and Regulation of the Estrogen Receptor MSigDB C2 BIOCARTA (v6.0) 4.156E-4 1.801E-3 8.898E-3 3.242E-2 2 35
19 137912 Hedgehog signaling events mediated by Gli proteins BioSystems: Pathway Interaction Database 6.579E-4 2.701E-3 1.334E-2
5.132E-2
2 44
20 1269527 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer BioSystems: REACTOME 7.191E-4 2.776E-3 1.371E-2
5.609E-2
2 46
21 169347 Notch-mediated HES/HEY network BioSystems: Pathway Interaction Database 7.830E-4 2.776E-3 1.371E-2
6.107E-2
2 48
22 1269537 NOTCH1 Intracellular Domain Regulates Transcription BioSystems: REACTOME 7.830E-4 2.776E-3 1.371E-2
6.107E-2
2 48
23 1268890 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer BioSystems: REACTOME 1.142E-3 3.181E-3 1.572E-2
8.907E-2
2 58
24 1268891 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants BioSystems: REACTOME 1.142E-3 3.181E-3 1.572E-2
8.907E-2
2 58
25 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 1.142E-3 3.181E-3 1.572E-2
8.907E-2
2 58
26 1268889 Constitutive Signaling by NOTCH1 PEST Domain Mutants BioSystems: REACTOME 1.142E-3 3.181E-3 1.572E-2
8.907E-2
2 58
27 1268888 Signaling by NOTCH1 PEST Domain Mutants in Cancer BioSystems: REACTOME 1.142E-3 3.181E-3 1.572E-2
8.907E-2
2 58
28 1268883 Signaling by NOTCH1 in Cancer BioSystems: REACTOME 1.142E-3 3.181E-3 1.572E-2
8.907E-2
2 58
29 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 1.476E-3 3.970E-3 1.961E-2
1.151E-1
2 66
30 1270433 Chromatin organization BioSystems: REACTOME 1.608E-3 4.045E-3 1.998E-2
1.254E-1
3 279
31 1270434 Chromatin modifying enzymes BioSystems: REACTOME 1.608E-3 4.045E-3 1.998E-2
1.254E-1
3 279
32 1269535 Signaling by NOTCH1 BioSystems: REACTOME 1.852E-3 4.513E-3 2.230E-2
1.444E-1
2 74
33 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 2.003E-3 4.714E-3 2.329E-2
1.562E-1
2 77
34 138073 C-MYB transcription factor network BioSystems: Pathway Interaction Database 2.055E-3 4.714E-3 2.329E-2
1.603E-1
2 78
35 1269874 NR1D1 (REV-ERBA) represses gene expression BioSystems: REACTOME 2.648E-3 5.902E-3 2.916E-2
2.066E-1
1 3
36 1268838 Organelle biogenesis and maintenance BioSystems: REACTOME 2.853E-3 6.182E-3 3.054E-2
2.226E-1
3 341
37 1269739 NoRC negatively regulates rRNA expression BioSystems: REACTOME 3.896E-3 8.214E-3 4.058E-2
3.039E-1
2 108
38 1269737 Negative epigenetic regulation of rRNA expression BioSystems: REACTOME 4.111E-3 8.438E-3 4.169E-2
3.207E-1
2 111
39 1269530 Signaling by NOTCH BioSystems: REACTOME 4.257E-3 8.514E-3 4.206E-2
3.321E-1
2 113
40 946598 Thyroid hormone signaling pathway BioSystems: KEGG 4.481E-3 8.737E-3 4.317E-2
3.495E-1
2 116
41 1270030 PPARA activates gene expression BioSystems: REACTOME 5.103E-3 9.698E-3 4.791E-2
3.980E-1
2 124
42 1339139 Activation of HOX genes during differentiation BioSystems: REACTOME 5.346E-3 9.698E-3 4.791E-2
4.170E-1
2 127
43 1339140 Activation of anterior HOX genes in hindbrain development during early embryogenesis BioSystems: REACTOME 5.346E-3 9.698E-3 4.791E-2
4.170E-1
2 127
44 1269734 Epigenetic regulation of gene expression BioSystems: REACTOME 7.577E-3 1.343E-2
6.635E-2
5.910E-1
2 152
45 1269377 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 8.065E-3 1.398E-2
6.907E-2
6.291E-1
2 157
46 M18837 Map Kinase Inactivation of SMRT Corepressor MSigDB C2 BIOCARTA (v6.0) 9.680E-3 1.641E-2
8.109E-2
7.550E-1
1 11
47 523016 Transcriptional misregulation in cancer BioSystems: KEGG 1.049E-2 1.715E-2
8.474E-2
8.185E-1
2 180
48 M13404 Control of Gene Expression by Vitamin D Receptor MSigDB C2 BIOCARTA (v6.0) 1.056E-2 1.715E-2
8.474E-2
8.233E-1
1 12
49 83100 Huntington's disease BioSystems: KEGG 1.199E-2 1.909E-2
9.432E-2
9.355E-1
2 193
50 137975 RXR and RAR heterodimerization with other nuclear receptor BioSystems: Pathway Interaction Database 1.231E-2 1.920E-2
9.483E-2
9.598E-1
1 14
Show 45 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 1620 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11877444 T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. Pubmed 2.939E-14 4.762E-11 3.794E-10 4.762E-11 5 20
2 9702189 SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Pubmed 1.015E-12 8.224E-10 6.553E-9 1.645E-9 4 9
3 21258344 Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Pubmed 2.306E-12 1.245E-9 9.923E-9 3.736E-9 5 45
4 9139820 A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Pubmed 3.080E-11 1.248E-8 9.940E-8 4.990E-8 3 3
5 27773593 FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Pubmed 3.896E-11 1.262E-8 1.006E-7 6.312E-8 4 20
6 19596656 Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Pubmed 4.812E-11 1.299E-8 1.035E-7 7.795E-8 4 21
7 9139821 Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Pubmed 1.232E-10 2.851E-8 2.272E-7 1.996E-7 3 4
8 15729358 Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells. Pubmed 3.079E-10 6.235E-8 4.968E-7 4.988E-7 3 5
9 15604093 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Pubmed 5.974E-10 9.974E-8 7.947E-7 9.678E-7 5 133
10 10640275 Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Pubmed 6.157E-10 9.974E-8 7.947E-7 9.974E-7 3 6
11 23770565 Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Pubmed 1.077E-9 1.454E-7 1.159E-6 1.745E-6 3 7
12 17956988 Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Pubmed 1.077E-9 1.454E-7 1.159E-6 1.745E-6 3 7
13 11430826 Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Pubmed 1.723E-9 1.861E-7 1.483E-6 2.792E-6 3 8
14 20935208 Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. Pubmed 1.723E-9 1.861E-7 1.483E-6 2.792E-6 3 8
15 10049357 Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Pubmed 1.723E-9 1.861E-7 1.483E-6 2.792E-6 3 8
16 10944117 Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. Pubmed 2.584E-9 2.204E-7 1.756E-6 4.187E-6 3 9
17 12007404 An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Pubmed 2.584E-9 2.204E-7 1.756E-6 4.187E-6 3 9
18 19244234 Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1. Pubmed 2.584E-9 2.204E-7 1.756E-6 4.187E-6 3 9
19 24821727 Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression. Pubmed 2.584E-9 2.204E-7 1.756E-6 4.187E-6 3 9
20 11931768 The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Pubmed 3.691E-9 2.848E-7 2.269E-6 5.980E-6 3 10
21 15001550 Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Pubmed 3.691E-9 2.848E-7 2.269E-6 5.980E-6 3 10
22 16469706 Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Pubmed 8.793E-9 6.474E-7 5.159E-6 1.424E-5 3 13
23 12590135 The histone deacetylase 9 gene encodes multiple protein isoforms. Pubmed 1.119E-8 7.658E-7 6.102E-6 1.813E-5 3 14
24 28611094 Agonist-specific protein interactomes of glucocorticoid and androgen receptor as revealed by proximity mapping. Pubmed 1.135E-8 7.658E-7 6.102E-6 1.838E-5 4 78
25 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 1.424E-8 9.225E-7 7.350E-6 2.306E-5 5 250
26 11102443 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. Pubmed 1.721E-8 1.032E-6 8.226E-6 2.787E-5 3 16
27 11013263 A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. Pubmed 1.721E-8 1.032E-6 8.226E-6 2.787E-5 3 16
28 23752268 The functional interactome landscape of the human histone deacetylase family. Pubmed 2.835E-8 1.640E-6 1.307E-5 4.593E-5 5 287
29 15572661 Negative modulation of androgen receptor transcriptional activity by Daxx. Pubmed 5.434E-8 2.934E-6 2.338E-5 8.803E-5 3 23
30 19737349 Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Pubmed 5.434E-8 2.934E-6 2.338E-5 8.803E-5 3 23
31 20956564 The mammalian Sin3 proteins are required for muscle development and sarcomere specification. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
32 19299558 Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
33 27733359 CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
34 10077563 Unique forms of human and mouse nuclear receptor corepressor SMRT. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
35 26166430 Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
36 22944139 Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
37 27780928 SIN3A and SIN3B differentially regulate breast cancer metastasis. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
38 21131350 Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants. Pubmed 1.069E-7 4.559E-6 3.633E-5 1.733E-4 2 2
39 26593974 Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Pubmed 1.244E-7 5.167E-6 4.117E-5 2.015E-4 3 30
40 22476904 Sin3 interacts with Foxk1 and regulates myogenic progenitors. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
41 22337871 Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
42 10406466 The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
43 11113190 Oligomerization of ETO is obligatory for corepressor interaction. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
44 21518914 EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
45 12904255 ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
46 12011091 RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
47 18052923 The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
48 19098224 Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
49 22101514 The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
50 15016838 Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors. Pubmed 3.208E-7 8.808E-6 7.018E-5 5.197E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 705 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AR AR interactions 1.589E-13 1.120E-10 7.994E-10 1.120E-10 9 329
2 int:NR3C1 NR3C1 interactions 2.676E-10 9.433E-8 6.732E-7 1.887E-7 7 268
3 int:PPARG PPARG interactions 6.933E-10 1.629E-7 1.163E-6 4.888E-7 6 156
4 int:VDR VDR interactions 7.498E-9 1.321E-6 9.430E-6 5.286E-6 5 103
5 int:FOXK2 FOXK2 interactions 3.044E-8 4.293E-6 3.063E-5 2.146E-5 5 136
6 int:RXRA RXRA interactions 3.917E-8 4.602E-6 3.284E-5 2.761E-5 5 143
7 int:REST REST interactions 5.017E-8 5.053E-6 3.606E-5 3.537E-5 4 53
8 int:NR1H2 NR1H2 interactions 7.778E-8 6.855E-6 4.892E-5 5.484E-5 4 59
9 int:SAP30 SAP30 interactions 1.016E-7 7.961E-6 5.681E-5 7.165E-5 4 63
10 int:NCOR1 NCOR1 interactions 1.622E-7 1.143E-5 8.158E-5 1.143E-4 5 190
11 int:THRB THRB interactions 2.419E-7 1.550E-5 1.106E-4 1.705E-4 4 78
12 int:THRA THRA interactions 4.508E-7 2.563E-5 1.829E-4 3.178E-4 4 91
13 int:ZSCAN5A ZSCAN5A interactions 4.726E-7 2.563E-5 1.829E-4 3.332E-4 3 22
14 int:SMARCA4 SMARCA4 interactions 9.604E-7 4.713E-5 3.363E-4 6.771E-4 5 272
15 int:NR1H4 NR1H4 interactions 1.003E-6 4.713E-5 3.363E-4 7.069E-4 3 28
16 int:NR2C1 NR2C1 interactions 1.242E-6 5.149E-5 3.675E-4 8.754E-4 3 30
17 int:CBFA2T2 CBFA2T2 interactions 1.242E-6 5.149E-5 3.675E-4 8.754E-4 3 30
18 int:NR1D2 NR1D2 interactions 1.374E-6 5.382E-5 3.841E-4 9.688E-4 3 31
19 int:IRF5 IRF5 interactions 1.997E-6 7.411E-5 5.289E-4 1.408E-3 3 35
20 int:NCOR2 NCOR2 interactions 2.192E-6 7.728E-5 5.515E-4 1.546E-3 4 135
21 int:SMARCE1 SMARCE1 interactions 2.535E-6 8.221E-5 5.867E-4 1.787E-3 4 140
22 int:ZBTB7A ZBTB7A interactions 2.571E-6 8.221E-5 5.867E-4 1.813E-3 3 38
23 int:ZBTB16 ZBTB16 interactions 2.682E-6 8.221E-5 5.867E-4 1.891E-3 4 142
24 int:NR1I2 NR1I2 interactions 3.009E-6 8.838E-5 6.307E-4 2.121E-3 3 40
25 int:IRF2BP2 IRF2BP2 interactions 3.245E-6 9.151E-5 6.530E-4 2.288E-3 3 41
26 int:HDAC2 HDAC2 interactions 4.831E-6 1.310E-4 9.348E-4 3.406E-3 5 378
27 int:NR1H3 NR1H3 interactions 5.589E-6 1.459E-4 1.041E-3 3.941E-3 3 49
28 int:RARA RARA interactions 6.437E-6 1.621E-4 1.157E-3 4.538E-3 4 177
29 int:PPARD PPARD interactions 7.939E-6 1.930E-4 1.377E-3 5.597E-3 3 55
30 int:PPARA PPARA interactions 8.385E-6 1.970E-4 1.406E-3 5.911E-3 3 56
31 int:CTBP1 CTBP1 interactions 9.832E-6 2.236E-4 1.596E-3 6.931E-3 4 197
32 int:HDAC9 HDAC9 interactions 1.256E-5 2.767E-4 1.975E-3 8.855E-3 3 64
33 int:ZBTB4 ZBTB4 interactions 1.390E-5 2.970E-4 2.120E-3 9.802E-3 2 8
34 int:KDM5B KDM5B interactions 1.442E-5 2.991E-4 2.134E-3 1.017E-2 3 67
35 int:RUNX1T1 RUNX1T1 interactions 1.576E-5 3.003E-4 2.143E-3 1.111E-2 3 69
36 int:GPS2 GPS2 interactions 1.576E-5 3.003E-4 2.143E-3 1.111E-2 3 69
37 int:TBL1X TBL1X interactions 1.576E-5 3.003E-4 2.143E-3 1.111E-2 3 69
38 int:SIN3A SIN3A interactions 1.873E-5 3.475E-4 2.480E-3 1.320E-2 4 232
39 int:NFE2L2 NFE2L2 interactions 1.946E-5 3.518E-4 2.510E-3 1.372E-2 3 74
40 int:HDAC3 HDAC3 interactions 2.320E-5 4.089E-4 2.918E-3 1.636E-2 4 245
41 int:NR6A1 NR6A1 interactions 2.728E-5 4.690E-4 3.347E-3 1.923E-2 2 11
42 int:NR1D1 NR1D1 interactions 3.272E-5 5.492E-4 3.919E-3 2.307E-2 2 12
43 int:HNF4A HNF4A interactions 3.503E-5 5.743E-4 4.098E-3 2.469E-2 3 90
44 int:CEBPB CEBPB interactions 4.383E-5 6.638E-4 4.737E-3 3.090E-2 3 97
45 int:PHF23 PHF23 interactions 4.508E-5 6.638E-4 4.737E-3 3.178E-2 2 14
46 int:CCL3 CCL3 interactions 4.508E-5 6.638E-4 4.737E-3 3.178E-2 2 14
47 int:HDAC7 HDAC7 interactions 4.519E-5 6.638E-4 4.737E-3 3.186E-2 3 98
48 int:DDX20 DDX20 interactions 4.519E-5 6.638E-4 4.737E-3 3.186E-2 3 98
49 int:JUN JUN interactions 4.861E-5 6.995E-4 4.991E-3 3.427E-2 4 296
50 int:SKIL SKIL interactions 6.209E-5 8.754E-4 6.247E-3 4.377E-2 3 109
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20q12-q13.12 20q12-q13.12 1.125E-3 1.461E-2 4.648E-2 1.462E-2 1 3
2 20q11 20q11 2.248E-3 1.461E-2 4.648E-2 2.923E-2 1 6
3 10q11.2 10q11.2 6.358E-3 2.747E-2
8.737E-2
8.266E-2
1 17
4 12q24 12q24 9.338E-3 2.747E-2
8.737E-2
1.214E-1
1 25
5 15q24.2 15q24.2 1.231E-2 2.747E-2
8.737E-2
1.600E-1
1 33
6 21q11.2 21q11.2 1.268E-2 2.747E-2
8.737E-2
1.648E-1
1 34
7 21q22.11 21q22.11 2.374E-2 4.117E-2
1.309E-1
3.087E-1
1 64
8 14q32.31 14q32.31 2.594E-2 4.117E-2
1.309E-1
3.373E-1
1 70
9 19p13.11 19p13.11 2.850E-2 4.117E-2
1.309E-1
3.705E-1
1 77
10 7q11.21 7q11.21 3.397E-2 4.416E-2
1.404E-1
4.416E-1
1 92
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 111 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 532 GATA zinc finger domain containing|Myb/SANT domain containing genenames.org 8.103E-7 6.482E-6 1.762E-5 6.482E-6 3 53
2 1306 EMSY complex|SIN3 histone deacetylase complex genenames.org 4.562E-6 1.825E-5 4.960E-5 3.650E-5 2 9
3 1243 EMSY complex genenames.org 8.359E-6 2.229E-5 6.058E-5 6.687E-5 2 12
4 775 Myb/SANT domain containing|Trinucleotide repeat containing genenames.org 9.581E-3 1.916E-2
5.208E-2
7.664E-2
1 25
5 506 Basic leucine zipper proteins genenames.org 1.870E-2 2.993E-2
8.133E-2
1.496E-1
1 49
6 1218 LIM domain containing genenames.org 2.248E-2 2.998E-2
8.148E-2
1.799E-1
1 59
Show 1 more annotation

13: Coexpression [Display Chart] 13 input genes in category / 1257 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15154 Interaction partners of class IIa histone deacetylases (HDAC). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.030E-9 1.009E-5 7.787E-5 1.009E-5 4 44
2 M3877 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 3.645E-6 1.527E-3 1.178E-2 4.581E-3 4 200
3 M5851 Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v6.0) 3.645E-6 1.527E-3 1.178E-2 4.581E-3 4 200
4 M1358 Early prostate development genes (up-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in localized vs metastatic prostate cancers. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.598E-5 5.023E-3 3.874E-2 2.009E-2 2 11
5 17880687-Table2 Human Embryo Heim07 40genes ChangedBasallyRIP140 GeneSigDB 9.400E-5 1.788E-2
1.379E-1
1.182E-1
2 26
6 M9109 Genes up-regulated in CD4 T conv: control versus over-expression of LEF1 and FOXP3 [GeneID=51176;50943]. MSigDB C7: Immunologic Signatures (v6.0) 9.492E-5 1.788E-2
1.379E-1
1.193E-1
3 164
7 M9401 Genes up-regulated in T reg: BCL6 [GeneID=604] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.170E-4 1.788E-2
1.379E-1
1.471E-1
3 176
8 15525570-SuppTable1 Human Ovarian Rae04 209genes GeneSigDB 1.490E-4 1.788E-2
1.379E-1
1.873E-1
3 191
9 M7558 Genes up-regulated in CD11b+ cells from spleen of BALB/c mice: healthy versus bearing C26GM colon carcinoma. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.788E-2
1.379E-1
2.114E-1
3 199
10 M7219 Genes up-regulated in mouse embryonic fibroblasts (MEF): control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.788E-2
1.379E-1
2.114E-1
3 199
11 M9317 Genes up-regulated in marginal zone B cells versus day 40 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.788E-2
1.379E-1
2.114E-1
3 199
12 M8635 Genes down-regulated in bone marrow-derived dendritic cells treated with 1,3-beta-D-oligoglucan [PubChem=11375554]: low dose versus high dose. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.788E-2
1.379E-1
2.146E-1
3 200
13 M12861 Cluster d2: genes down-regulated consistently in WS1 cells (fibroblast) between 6 h and 24 h after irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.360E-4 2.282E-2
1.761E-1
2.967E-1
2 41
14 M1470 Cluster 5: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.974E-4 2.671E-2
2.060E-1
3.739E-1
2 46
Show 9 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 714 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingGonad e11.5 ovary + mesonephros k5 100 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 6.832E-5 4.878E-2
3.487E-1
4.878E-2 2 21

15: Computational [Display Chart] 8 input genes in category / 34 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 13 input genes in category / 704 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-7113-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.307E-6 2.386E-3 1.702E-2 4.440E-3 3 205
2 hsa-miR-6867-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.778E-6 2.386E-3 1.702E-2 4.772E-3 3 210
3 hsa-miR-4685-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.420E-5 2.528E-3 1.804E-2 1.000E-2 3 269
4 hsa-miR-4287:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.436E-5 2.528E-3 1.804E-2 1.011E-2 3 270
5 hsa-miR-4469:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.127E-5 2.994E-3 2.136E-2 1.497E-2 3 308
6 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 4.192E-5 4.651E-3 3.318E-2 2.951E-2 3 387
7 hsa-miR-621:mirSVR highEffct hsa-miR-621:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.624E-5 4.651E-3 3.318E-2 3.255E-2 3 400
8 hsa-miR-4300:mirSVR highEffct hsa-miR-4300:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.573E-5 4.904E-3 3.499E-2 3.924E-2 3 426
9 hsa-miR-3668:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.169E-5 5.203E-3 3.712E-2
5.047E-2
2 70
10 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 8.433E-5 5.203E-3 3.712E-2
5.937E-2
3 490
11 hsa-miR-5006-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.456E-5 5.203E-3 3.712E-2
5.953E-2
2 76
12 hsa-miR-34a-3p:Functional MTI Functional MTI miRTarbase 9.608E-5 5.203E-3 3.712E-2
6.764E-2
2 81
13 TCTGGAC,MIR-198:MSigDB TCTGGAC,MIR-198:MSigDB MSigDB 9.608E-5 5.203E-3 3.712E-2
6.764E-2
2 81
14 hsa-miR-4802-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.187E-4 5.967E-3 4.257E-2
8.353E-2
2 90
15 hsa-miR-621:PITA hsa-miR-621:PITA TOP PITA 1.494E-4 7.014E-3
5.004E-2
1.052E-1
2 101
16 hsa-miR-6871-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.773E-4 7.070E-3
5.044E-2
1.248E-1
2 110
17 hsa-miR-1185-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.005E-4 7.070E-3
5.044E-2
1.411E-1
2 117
18 hsa-miR-6798-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.109E-4 7.070E-3
5.044E-2
1.485E-1
2 120
19 ACAGGGT,MIR-10B:MSigDB ACAGGGT,MIR-10B:MSigDB MSigDB 2.109E-4 7.070E-3
5.044E-2
1.485E-1
2 120
20 ACAGGGT,MIR-10A:MSigDB ACAGGGT,MIR-10A:MSigDB MSigDB 2.109E-4 7.070E-3
5.044E-2
1.485E-1
2 120
21 hsa-miR-1185-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.109E-4 7.070E-3
5.044E-2
1.485E-1
2 120
22 hsa-miR-198:PITA hsa-miR-198:PITA TOP PITA 3.247E-4 1.039E-2
7.414E-2
2.286E-1
2 149
23 hsa-miR-7515:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.423E-4 1.048E-2
7.475E-2
2.410E-1
2 153
24 hsa-miR-361-5p:Functional MTI Functional MTI miRTarbase 3.742E-4 1.054E-2
7.518E-2
2.634E-1
2 160
25 hsa-miR-628-3p:PITA hsa-miR-628-3p:PITA TOP PITA 3.742E-4 1.054E-2
7.518E-2
2.634E-1
2 160
26 hsa-miR-149:PITA hsa-miR-149:PITA TOP PITA 4.221E-4 1.086E-2
7.745E-2
2.972E-1
2 170
27 hsa-miR-10b:PITA hsa-miR-10b:PITA TOP PITA 4.371E-4 1.086E-2
7.745E-2
3.077E-1
2 173
28 hsa-miR-10a:PITA hsa-miR-10a:PITA TOP PITA 4.371E-4 1.086E-2
7.745E-2
3.077E-1
2 173
29 hsa-miR-532-5p:TargetScan hsa-miR-532-5p TargetScan 4.472E-4 1.086E-2
7.745E-2
3.148E-1
2 175
30 GGGACCA,MIR-133B:MSigDB GGGACCA,MIR-133B:MSigDB MSigDB 5.266E-4 1.196E-2
8.532E-2
3.707E-1
2 190
31 GGGACCA,MIR-133A:MSigDB GGGACCA,MIR-133A:MSigDB MSigDB 5.266E-4 1.196E-2
8.532E-2
3.707E-1
2 190
32 hsa-miR-220c:PITA hsa-miR-220c:PITA TOP PITA 6.064E-4 1.334E-2
9.518E-2
4.269E-1
2 204
33 hsa-miR-576-3p:PITA hsa-miR-576-3p:PITA TOP PITA 6.668E-4 1.422E-2
1.015E-1
4.694E-1
2 214
34 hsa-miR-873:PITA hsa-miR-873:PITA TOP PITA 7.364E-4 1.494E-2
1.066E-1
5.185E-1
2 225
35 hsa-miR-1205:PITA hsa-miR-1205:PITA TOP PITA 7.429E-4 1.494E-2
1.066E-1
5.230E-1
2 226
36 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 8.163E-4 1.596E-2
1.139E-1
5.747E-1
2 237
37 hsa-miR-10b-5p:TargetScan hsa-miR-10b-5p TargetScan 8.647E-4 1.602E-2
1.143E-1
6.087E-1
2 244
38 hsa-miR-10a-5p:TargetScan hsa-miR-10a-5p TargetScan 8.647E-4 1.602E-2
1.143E-1
6.087E-1
2 244
39 hsa-miR-6856-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.289E-4 1.677E-2
1.196E-1
6.540E-1
2 253
40 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 1.026E-3 1.738E-2
1.240E-1
7.221E-1
2 266
41 hsa-miR-93-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.049E-3 1.738E-2
1.240E-1
7.383E-1
2 269
42 hsa-miR-302f:PITA hsa-miR-302f:PITA TOP PITA 1.080E-3 1.738E-2
1.240E-1
7.601E-1
2 273
43 hsa-miR-624:PITA hsa-miR-624:PITA TOP PITA 1.103E-3 1.738E-2
1.240E-1
7.767E-1
2 276
44 hsa-miR-1253:PITA hsa-miR-1253:PITA TOP PITA 1.103E-3 1.738E-2
1.240E-1
7.767E-1
2 276
45 hsa-miR-4756-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.184E-3 1.738E-2
1.240E-1
8.333E-1
2 286
46 hsa-miR-1321:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.192E-3 1.738E-2
1.240E-1
8.391E-1
2 287
47 hsa-miR-4739:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.217E-3 1.738E-2
1.240E-1
8.565E-1
2 290
48 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 1.250E-3 1.738E-2
1.240E-1
8.799E-1
2 294
49 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 1.250E-3 1.738E-2
1.240E-1
8.799E-1
2 294
50 hsa-miR-4755-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.258E-3 1.738E-2
1.240E-1
8.859E-1
2 295
Show 45 more annotations

17: Drug [Display Chart] 13 input genes in category / 2290 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000508110 AC1LA6KT Stitch 1.553E-8 3.556E-5 2.956E-4 3.556E-5 4 51
2 CID000091649 hydroxyflutamide Stitch 2.702E-7 2.510E-4 2.087E-3 6.188E-4 4 103
3 CID000101525 telL Stitch 3.289E-7 2.510E-4 2.087E-3 7.531E-4 3 25
4 CID000019390 AC1L2E0P Stitch 5.003E-7 2.864E-4 2.381E-3 1.146E-3 5 307
5 CID000033584 halofenate Stitch 1.793E-6 8.212E-4 6.827E-3 4.106E-3 2 4
6 ctd:C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate CTD 2.813E-6 9.392E-4 7.808E-3 6.443E-3 4 185
7 CID000644030 DY131 Stitch 2.987E-6 9.392E-4 7.808E-3 6.841E-3 2 5
8 CID000002914 AC1L1ERB Stitch 3.714E-6 9.392E-4 7.808E-3 8.506E-3 3 55
9 ctd:C031324 tris(chloroethyl)phosphate CTD 3.923E-6 9.392E-4 7.808E-3 8.985E-3 3 56
10 CID000005410 NSC98537 Stitch 4.183E-6 9.392E-4 7.808E-3 9.580E-3 5 473
11 CID000177324 SNAG Stitch 4.597E-6 9.392E-4 7.808E-3 1.053E-2 3 59
12 CID000013766 AC1L22FJ Stitch 4.921E-6 9.392E-4 7.808E-3 1.127E-2 4 213
13 ctd:C508548 ormeloxifene CTD 8.357E-6 1.406E-3 1.169E-2 1.914E-2 2 8
14 CID005282911 13-hydroxyoctadecanoic acid Stitch 9.498E-6 1.406E-3 1.169E-2 2.175E-2 3 75
15 CID000160615 4-hydroxytestosterone Stitch 1.069E-5 1.406E-3 1.169E-2 2.448E-2 3 78
16 ctd:C011126 tetraiodothyroacetic acid CTD 1.074E-5 1.406E-3 1.169E-2 2.460E-2 2 9
17 ctd:D000450 Aldosterone CTD 1.111E-5 1.406E-3 1.169E-2 2.544E-2 3 79
18 CID000452307 A-74702 Stitch 1.154E-5 1.406E-3 1.169E-2 2.642E-2 3 80
19 CID004568637 AC1ND2OB Stitch 1.166E-5 1.406E-3 1.169E-2 2.671E-2 4 265
20 CID000004308 F-L-Leu Stitch 1.289E-5 1.476E-3 1.227E-2 2.952E-2 3 83
21 CID000063042 dexamethasone oxetanone Stitch 1.967E-5 2.145E-3 1.784E-2 4.505E-2 2 12
22 ctd:D000737 Androstenols CTD 2.324E-5 2.300E-3 1.912E-2
5.322E-2
2 13
23 CID006368594 AC1OC6D1 Stitch 2.537E-5 2.300E-3 1.912E-2
5.810E-2
3 104
24 CID000005098 AC1L1JLU Stitch 2.537E-5 2.300E-3 1.912E-2
5.810E-2
3 104
25 CID000000015 5 alpha-dihydrotestosterone Stitch 2.538E-5 2.300E-3 1.912E-2
5.811E-2
4 323
26 CID000007833 4-vinylcyclohexene diepoxide Stitch 2.611E-5 2.300E-3 1.912E-2
5.979E-2
3 105
27 CID000002375 bicalutamide Stitch 4.396E-5 3.729E-3 3.100E-2
1.007E-1
3 125
28 ctd:C016805 tris(1,3-dichloro-2-propyl)phosphate CTD 5.457E-5 4.463E-3 3.711E-2
1.250E-1
4 393
29 CID000001424 13-HODE Stitch 5.653E-5 4.464E-3 3.711E-2
1.295E-1
3 136
30 CID000001927 9-HODE Stitch 6.428E-5 4.907E-3 4.079E-2
1.472E-1
3 142
31 CID000482133 5'-TG-3 Stitch 9.644E-5 7.013E-3
5.830E-2
2.208E-1
2 26
32 CID009547945 DB08184 Stitch 1.040E-4 7.013E-3
5.830E-2
2.382E-1
3 167
33 CID000101989 androstenol Stitch 1.041E-4 7.013E-3
5.830E-2
2.384E-1
2 27
34 ctd:C502354 lithocholic acid acetate CTD 1.041E-4 7.013E-3
5.830E-2
2.384E-1
2 27
35 CID000446054 In-G Stitch 1.097E-4 7.175E-3
5.965E-2
2.511E-1
3 170
36 ctd:C078903 seocalcitol CTD 1.155E-4 7.347E-3
6.108E-2
2.645E-1
3 173
37 ctd:C070081 fulvestrant CTD 1.243E-4 7.502E-3
6.237E-2
2.846E-1
4 486
38 7245 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.257E-4 7.502E-3
6.237E-2
2.878E-1
3 178
39 CID000033184 azoxymethane Stitch 1.278E-4 7.502E-3
6.237E-2
2.926E-1
3 179
40 1951 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A Broad Institute CMAP Down 1.342E-4 7.683E-3
6.387E-2
3.073E-1
3 182
41 CID000021470 thalicarpine Stitch 1.469E-4 8.205E-3
6.821E-2
3.364E-1
2 32
42 7360 UP Methyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.696E-4 8.959E-3
7.448E-2
3.883E-1
3 197
43 1648 UP nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.721E-4 8.959E-3
7.448E-2
3.941E-1
3 198
44 CID000643668 discodermolide Stitch 1.760E-4 8.959E-3
7.448E-2
4.031E-1
2 35
45 CID010062716 DR-0 Stitch 1.760E-4 8.959E-3
7.448E-2
4.031E-1
2 35
46 CID000446738 1kkq Stitch 1.863E-4 9.277E-3
7.712E-2
4.267E-1
2 36
47 CID000065366 baccatin III Stitch 1.969E-4 9.595E-3
7.977E-2
4.510E-1
2 37
48 CID000130105 CV-1 Stitch 2.134E-4 1.018E-2
8.466E-2
4.888E-1
3 213
49 CID000081462 BT-B Stitch 3.144E-4 1.469E-2
1.221E-1
7.199E-1
3 243
50 CID000006326 vinylene Stitch 3.220E-4 1.475E-2
1.226E-1
7.374E-1
3 245
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 268 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0393639 Hashimoto's encephalitis DisGeNET BeFree 4.611E-5 1.236E-2
7.624E-2
1.236E-2 2 13
2 C2940786 Thyroid Hormone Resistance Syndrome DisGeNET Curated 3.285E-4 2.687E-2
1.658E-1
8.804E-2
2 34
3 C4025697 Gastrointestinal atresia DisGeNET Curated 8.022E-4 2.687E-2
1.658E-1
2.150E-1
1 1
4 cv:C2673257 Epilepsy, progressive myoclonic 3 Clinical Variations 8.022E-4 2.687E-2
1.658E-1
2.150E-1
1 1
5 C3150674 CHROMOSOME 15q24 DELETION SYNDROME DisGeNET Curated 8.022E-4 2.687E-2
1.658E-1
2.150E-1
1 1
6 C0033936 Psychoses, Alcoholic DisGeNET BeFree 8.022E-4 2.687E-2
1.658E-1
2.150E-1
1 1
7 OMIN:611726 EPILEPSY, PROGRESSIVE MYOCLONIC 3; EPM3 OMIM 8.022E-4 2.687E-2
1.658E-1
2.150E-1
1 1
8 C2673257 EPILEPSY, PROGRESSIVE MYOCLONIC 3 DisGeNET Curated 8.022E-4 2.687E-2
1.658E-1
2.150E-1
1 1
9 C0007124 Noninfiltrating Intraductal Carcinoma DisGeNET Curated 1.284E-3 2.866E-2
1.768E-1
3.440E-1
3 280
10 C2676254 Prickle1-Related Progressive Myoclonus Epilepsy with Ataxia DisGeNET Curated 1.604E-3 2.866E-2
1.768E-1
4.298E-1
1 2
11 C1096154 Kinsbourne Syndrome DisGeNET BeFree 1.604E-3 2.866E-2
1.768E-1
4.298E-1
1 2
12 C0003079 Anisocoria DisGeNET Curated 1.604E-3 2.866E-2
1.768E-1
4.298E-1
1 2
13 C4021029 Conspicuously happy disposition DisGeNET Curated 1.604E-3 2.866E-2
1.768E-1
4.298E-1
1 2
14 C0221100 Hangover from any Alcohol or Other Drugs substance DisGeNET BeFree 1.604E-3 2.866E-2
1.768E-1
4.298E-1
1 2
15 C0277873 Nasal flaring DisGeNET Curated 1.604E-3 2.866E-2
1.768E-1
4.298E-1
1 2
16 OMIN:613406 CHROMOSOME 15q24 DELETION SYNDROME OMIM 2.405E-3 3.581E-2
2.209E-1
6.445E-1
1 3
17 C0393756 Hangover from alcohol DisGeNET Curated 2.405E-3 3.581E-2
2.209E-1
6.445E-1
1 3
18 C0344263 Posterior lenticonus DisGeNET Curated 2.405E-3 3.581E-2
2.209E-1
6.445E-1
1 3
19 C1844562 Medial eyebrow flare DisGeNET Curated 3.205E-3 4.091E-2
2.524E-1
8.590E-1
1 4
20 C0796022 Lujan Fryns syndrome DisGeNET Curated 3.205E-3 4.091E-2
2.524E-1
8.590E-1
1 4
21 C0338657 Age-associated memory impairment DisGeNET BeFree 3.205E-3 4.091E-2
2.524E-1
8.590E-1
1 4
22 C0431369 Dysgenesis of corpus callosum DisGeNET Curated 4.005E-3 4.128E-2
2.547E-1
1.000E0
1 5
23 C3697269 15q24 Microdeletion DisGeNET Curated 4.005E-3 4.128E-2
2.547E-1
1.000E0
1 5
24 C0038478 Struma Ovarii DisGeNET BeFree 4.005E-3 4.128E-2
2.547E-1
1.000E0
1 5
25 C1844809 Thick nasal alae DisGeNET Curated 4.005E-3 4.128E-2
2.547E-1
1.000E0
1 5
26 C0240701 Small penis DisGeNET Curated 4.005E-3 4.128E-2
2.547E-1
1.000E0
1 5
27 C0021828 Intestinal Atresia DisGeNET Curated 4.804E-3 4.693E-2
2.895E-1
1.000E0
1 6
28 C3714948 PACHYONYCHIA CONGENITA 3 DisGeNET Curated 5.207E-3 4.693E-2
2.895E-1
1.000E0
2 137
29 C0393626 Opsoclonus-Myoclonus Syndrome DisGeNET Curated 5.603E-3 4.693E-2
2.895E-1
1.000E0
1 7
30 C3276036 High anterior hairline DisGeNET Curated 5.603E-3 4.693E-2
2.895E-1
1.000E0
1 7
31 cv:C0238463 Papillary thyroid carcinoma Clinical Variations 5.603E-3 4.693E-2
2.895E-1
1.000E0
1 7
32 C0795875 Chromosome 21 monosomy DisGeNET BeFree 5.603E-3 4.693E-2
2.895E-1
1.000E0
1 7
Show 27 more annotations