Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc93_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 18 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004222 metalloendopeptidase activity 1.405E-18 2.529E-17 8.840E-17 2.529E-17 8 113
2 GO:0008237 metallopeptidase activity 9.139E-17 8.225E-16 2.875E-15 1.645E-15 8 188
3 GO:0004175 endopeptidase activity 1.218E-13 7.310E-13 2.555E-12 2.193E-12 8 457
4 GO:0017124 SH3 domain binding 6.319E-10 2.843E-9 9.938E-9 1.137E-8 5 123
5 GO:0005178 integrin binding 1.154E-7 4.154E-7 1.452E-6 2.077E-6 4 121
6 GO:0050839 cell adhesion molecule binding 1.014E-6 3.041E-6 1.063E-5 1.825E-5 4 208
7 GO:0005138 interleukin-6 receptor binding 2.998E-3 7.708E-3 2.694E-2
5.396E-2
 1 7
8 GO:0005112 Notch binding 8.544E-3 1.922E-2
6.719E-2
1.538E-1
 1 20
9 GO:0043236 laminin binding 1.364E-2 2.728E-2
9.534E-2
2.455E-1
 1 32
10 GO:0050840 extracellular matrix binding 2.376E-2 4.277E-2
1.495E-1
4.277E-1
 1 56
11 GO:0005080 protein kinase C binding 2.628E-2 4.300E-2
1.503E-1
4.730E-1
 1 62
12 GO:0005518 collagen binding 3.046E-2 4.569E-2
1.597E-1
5.483E-1
 1 72
Show 7 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 293 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis 4.843E-7 8.682E-5 5.434E-4 1.419E-4 2 3
2 GO:0006509 membrane protein ectodomain proteolysis 5.926E-7 8.682E-5 5.434E-4 1.736E-4 3 42
3 GO:0033619 membrane protein proteolysis 1.351E-6 1.319E-4 8.257E-4 3.958E-4 3 55
4 GO:0007229 integrin-mediated signaling pathway 7.069E-6 5.178E-4 3.241E-3 2.071E-3 3 95
5 GO:0033627 cell adhesion mediated by integrin 2.118E-4 1.241E-2
7.770E-2
6.207E-2
 2 52
6 GO:0000768 syncytium formation by plasma membrane fusion 2.729E-4 1.303E-2
8.155E-2
7.997E-2
 2 59
7 GO:0006949 syncytium formation 3.113E-4 1.303E-2
8.155E-2
9.120E-2
 2 63
8 GO:0034241 positive regulation of macrophage fusion 1.288E-3 3.871E-2
2.423E-1
3.775E-1
 1 3
9 GO:0044691 tooth eruption 1.288E-3 3.871E-2
2.423E-1
3.775E-1
 1 3
10 GO:0034239 regulation of macrophage fusion 1.717E-3 3.871E-2
2.423E-1
5.032E-1
 1 4
11 GO:0033023 mast cell homeostasis 1.717E-3 3.871E-2
2.423E-1
5.032E-1
 1 4
12 GO:0033024 mast cell apoptotic process 1.717E-3 3.871E-2
2.423E-1
5.032E-1
 1 4
13 GO:0033025 regulation of mast cell apoptotic process 1.717E-3 3.871E-2
2.423E-1
5.032E-1
 1 4
14 GO:0034238 macrophage fusion 2.146E-3 4.192E-2
2.624E-1
6.289E-1
 1 5
15 GO:0035624 receptor transactivation 2.146E-3 4.192E-2
2.624E-1
6.289E-1
 1 5
16 GO:0007179 transforming growth factor beta receptor signaling pathway 2.614E-3 4.535E-2
2.838E-1
7.660E-1
 2 184
17 GO:0007160 cell-matrix adhesion 3.263E-3 4.535E-2
2.838E-1
9.561E-1
 2 206
18 GO:0051547 regulation of keratinocyte migration 3.432E-3 4.535E-2
2.838E-1
1.000E0
 1 8
19 GO:0051549 positive regulation of keratinocyte migration 3.432E-3 4.535E-2
2.838E-1
1.000E0
 1 8
20 GO:0042117 monocyte activation 3.432E-3 4.535E-2
2.838E-1
1.000E0
 1 8
21 GO:0071374 cellular response to parathyroid hormone stimulus 3.860E-3 4.535E-2
2.838E-1
1.000E0
 1 9
22 GO:0071560 cellular response to transforming growth factor beta stimulus 4.049E-3 4.535E-2
2.838E-1
1.000E0
 2 230
23 GO:0071559 response to transforming growth factor beta 4.153E-3 4.535E-2
2.838E-1
1.000E0
 2 233
24 GO:0010820 positive regulation of T cell chemotaxis 4.716E-3 4.535E-2
2.838E-1
1.000E0
 1 11
25 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 4.716E-3 4.535E-2
2.838E-1
1.000E0
 1 11
26 GO:0007162 negative regulation of cell adhesion 4.765E-3 4.535E-2
2.838E-1
1.000E0
 2 250
27 GO:0008406 gonad development 4.802E-3 4.535E-2
2.838E-1
1.000E0
 2 251
28 GO:0003007 heart morphogenesis 4.839E-3 4.535E-2
2.838E-1
1.000E0
 2 252
29 GO:0045137 development of primary sexual characteristics 4.990E-3 4.535E-2
2.838E-1
1.000E0
 2 256
30 GO:1900121 negative regulation of receptor binding 5.144E-3 4.535E-2
2.838E-1
1.000E0
 1 12
31 GO:0034612 response to tumor necrosis factor 5.416E-3 4.535E-2
2.838E-1
1.000E0
 2 267
32 GO:0071107 response to parathyroid hormone 5.572E-3 4.535E-2
2.838E-1
1.000E0
 1 13
33 GO:0001542 ovulation from ovarian follicle 5.572E-3 4.535E-2
2.838E-1
1.000E0
 1 13
34 GO:0051546 keratinocyte migration 5.572E-3 4.535E-2
2.838E-1
1.000E0
 1 13
35 GO:0033631 cell-cell adhesion mediated by integrin 5.572E-3 4.535E-2
2.838E-1
1.000E0
 1 13
36 GO:0010819 regulation of T cell chemotaxis 5.572E-3 4.535E-2
2.838E-1
1.000E0
 1 13
37 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 6.427E-3 4.856E-2
3.040E-1
1.000E0
 1 15
38 GO:0060347 heart trabecula formation 6.427E-3 4.856E-2
3.040E-1
1.000E0
 1 15
39 GO:0007220 Notch receptor processing 6.854E-3 4.856E-2
3.040E-1
1.000E0
 1 16
40 GO:0007548 sex differentiation 7.193E-3 4.856E-2
3.040E-1
1.000E0
 2 309
41 GO:0031293 membrane protein intracellular domain proteolysis 7.281E-3 4.856E-2
3.040E-1
1.000E0
 1 17
42 GO:1900120 regulation of receptor binding 7.281E-3 4.856E-2
3.040E-1
1.000E0
 1 17
43 GO:0002467 germinal center formation 7.281E-3 4.856E-2
3.040E-1
1.000E0
 1 17
44 GO:0035313 wound healing, spreading of epidermal cells 7.708E-3 4.856E-2
3.040E-1
1.000E0
 1 18
45 GO:0010042 response to manganese ion 7.708E-3 4.856E-2
3.040E-1
1.000E0
 1 18
46 GO:0033630 positive regulation of cell adhesion mediated by integrin 7.708E-3 4.856E-2
3.040E-1
1.000E0
 1 18
47 GO:0031589 cell-substrate adhesion 7.790E-3 4.856E-2
3.040E-1
1.000E0
 2 322
48 GO:0010818 T cell chemotaxis 8.134E-3 4.864E-2
3.044E-1
1.000E0
 1 19
49 GO:0071380 cellular response to prostaglandin E stimulus 8.134E-3 4.864E-2
3.044E-1
1.000E0
 1 19
50 GO:0032496 response to lipopolysaccharide 8.751E-3 4.876E-2
3.052E-1
1.000E0
 2 342
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 24 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005912 adherens junction 8.284E-4 1.988E-2
7.508E-2
 1.988E-2 3 484
2 GO:0009897 external side of plasma membrane 6.920E-3 4.844E-2
1.829E-1
1.661E-1
 2 310
3 GO:0005925 focal adhesion 1.094E-2 4.844E-2
1.829E-1
2.625E-1
 2 393
4 GO:0005924 cell-substrate adherens junction 1.120E-2 4.844E-2
1.829E-1
2.689E-1
 2 398
5 GO:0030055 cell-substrate junction 1.148E-2 4.844E-2
1.829E-1
2.754E-1
 2 403
6 GO:0031233 intrinsic component of external side of plasma membrane 1.211E-2 4.844E-2
1.829E-1
2.906E-1
 1 29
Show 1 more annotation

4: Human Phenotype [Display Chart] 3 input genes in category / 48 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 451 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0010627 enlarged tricuspid valve 2.557E-12 5.766E-10 3.857E-9 1.153E-9 4 7
2 MP:0010618 enlarged mitral valve 2.557E-12 5.766E-10 3.857E-9 1.153E-9 4 7
3 MP:0002624 abnormal tricuspid valve morphology 6.845E-12 1.029E-9 6.884E-9 3.087E-9 5 35
4 MP:0010629 thick tricuspid valve 1.533E-11 1.728E-9 1.156E-8 6.914E-9 4 10
5 MP:0000286 abnormal mitral valve morphology 5.465E-11 4.929E-9 3.298E-8 2.465E-8 5 52
6 MP:0002748 abnormal pulmonary valve morphology 1.358E-10 1.021E-8 6.831E-8 6.127E-8 5 62
7 MP:0010428 abnormal heart right ventricle outflow tract morphology 2.357E-10 1.518E-8 1.016E-7 1.063E-7 5 69
8 MP:0002747 abnormal aortic valve morphology 6.074E-10 3.044E-8 2.036E-7 2.740E-7 5 83
9 MP:0010429 abnormal heart left ventricle outflow tract morphology 6.074E-10 3.044E-8 2.036E-7 2.740E-7 5 83
10 MP:0002745 abnormal atrioventricular valve morphology 1.345E-9 6.067E-8 4.059E-7 6.067E-7 5 97
11 MP:0010435 abnormal heart atrium and ventricle connection 1.652E-9 6.775E-8 4.532E-7 7.452E-7 5 101
12 MP:0010224 abnormal heart ventricle outflow tract morphology 2.669E-9 1.003E-7 6.711E-7 1.204E-6 5 111
13 MP:0002746 abnormal semilunar valve morphology 2.922E-9 1.014E-7 6.782E-7 1.318E-6 5 113
14 MP:0011090 perinatal lethality, incomplete penetrance 7.080E-9 2.281E-7 1.526E-6 3.193E-6 6 332
15 MP:0000285 abnormal heart valve morphology 4.825E-8 1.451E-6 9.704E-6 2.176E-5 5 197
16 MP:0003920 abnormal heart right ventricle morphology 5.205E-8 1.467E-6 9.815E-6 2.347E-5 5 200
17 MP:0001302 eyelids open at birth 1.750E-7 4.642E-6 3.106E-5 7.892E-5 4 89
18 MP:0010402 ventricular septal defect 2.904E-7 7.277E-6 4.868E-5 1.310E-4 5 282
19 MP:0003921 abnormal heart left ventricle morphology 7.929E-7 1.882E-5 1.259E-4 3.576E-4 5 345
20 MP:0000281 abnormal interventricular septum morphology 1.298E-6 2.928E-5 1.959E-4 5.855E-4 5 381
21 MP:0000284 double outlet right ventricle 2.533E-6 5.372E-5 3.594E-4 1.142E-3 4 173
22 MP:0006113 abnormal heart septum morphology 2.621E-6 5.372E-5 3.594E-4 1.182E-3 5 439
23 MP:0010426 abnormal heart and great artery attachment 1.079E-5 2.093E-4 1.400E-3 4.867E-3 4 249
24 MP:0010425 abnormal heart and great vessel attachment 1.114E-5 2.093E-4 1.400E-3 5.024E-3 4 251
25 MP:0001340 abnormal eyelid morphology 1.340E-5 2.418E-4 1.618E-3 6.046E-3 4 263
26 MP:0010605 thick pulmonary valve cusps 1.758E-5 3.050E-4 2.040E-3 7.930E-3 2 10
27 MP:0003711 pathological neovascularization 2.799E-5 4.676E-4 3.128E-3 1.262E-2 3 98
28 MP:0010620 thick mitral valve 3.045E-5 4.904E-4 3.281E-3 1.373E-2 2 13
29 MP:0010593 thick aortic valve cusps 5.302E-5 8.245E-4 5.516E-3 2.391E-2 2 17
30 MP:0006117 aortic valve stenosis 7.400E-5 1.077E-3 7.202E-3 3.337E-2 2 20
31 MP:0010448 heart left ventricle outflow tract stenosis 7.400E-5 1.077E-3 7.202E-3 3.337E-2 2 20
32 MP:0009660 abnormal induced retinal neovascularization 9.844E-5 1.387E-3 9.281E-3 4.440E-2 2 23
33 MP:0010601 thick pulmonary valve 1.074E-4 1.467E-3 9.815E-3 4.842E-2 2 24
34 MP:0000293 absent myocardial trabeculae 1.167E-4 1.547E-3 1.035E-2
5.261E-2
 2 25
35 MP:0011648 thick heart valve cusps 1.263E-4 1.628E-3 1.089E-2
5.698E-2
 2 26
36 MP:0010602 abnormal pulmonary valve cusp morphology 1.468E-4 1.790E-3 1.197E-2
6.622E-2
 2 28
37 MP:0010594 thick aortic valve 1.468E-4 1.790E-3 1.197E-2
6.622E-2
 2 28
38 MP:0010595 abnormal aortic valve cusp morphology 3.172E-4 3.765E-3 2.519E-2
1.431E-1
 2 41
39 MP:0008852 retinal neovascularization 3.656E-4 4.228E-3 2.828E-2
1.649E-1
 2 44
40 MP:0010423 heart right ventricle aneurysm 6.760E-4 7.622E-3
5.099E-2
3.049E-1
 1 1
41 MP:0011929 abnormal aortic valve flow 1.352E-3 1.418E-2
9.484E-2
6.096E-1
 1 2
42 MP:0011303 absent kidney papilla 1.352E-3 1.418E-2
9.484E-2
6.096E-1
 1 2
43 MP:0011927 abnormal cardiac valve flow 1.352E-3 1.418E-2
9.484E-2
6.096E-1
 1 2
44 MP:0004285 absent Descemet membrane 2.027E-3 2.071E-2
1.386E-1
9.141E-1
 1 3
45 MP:0000249 abnormal blood vessel physiology 2.066E-3 2.071E-2
1.386E-1
9.320E-1
 3 421
46 MP:0003447 decreased tumor growth/size 2.605E-3 2.487E-2
1.664E-1
1.000E0
 2 118
47 MP:0011491 ureteropelvic junction obstruction 2.702E-3 2.487E-2
1.664E-1
1.000E0
 1 4
48 MP:0010455 aortopulmonary window 2.702E-3 2.487E-2
1.664E-1
1.000E0
 1 4
49 MP:0010421 ventricular aneurysm 2.702E-3 2.487E-2
1.664E-1
1.000E0
 1 4
50 MP:0001316 corneal scarring 3.376E-3 2.835E-2
1.897E-1
1.000E0
 1 5
Show 45 more annotations

6: Domain [Display Chart] 8 input genes in category / 40 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR002870 Peptidase M12B N InterPro 1.637E-22 1.169E-21 5.002E-21 6.547E-21 8 39
2 PF01562 Pep M12B propep Pfam 1.637E-22 1.169E-21 5.002E-21 6.547E-21 8 39
3 PF01421 Reprolysin Pfam 2.046E-22 1.169E-21 5.002E-21 8.184E-21 8 40
4 PS00427 DISINTEGRIN 1 PROSITE 2.046E-22 1.169E-21 5.002E-21 8.184E-21 8 40
5 PS50215 ADAM MEPRO PROSITE 2.046E-22 1.169E-21 5.002E-21 8.184E-21 8 40
6 IPR001590 Peptidase M12B InterPro 2.046E-22 1.169E-21 5.002E-21 8.184E-21 8 40
7 PS50214 DISINTEGRIN 2 PROSITE 2.046E-22 1.169E-21 5.002E-21 8.184E-21 8 40
8 IPR001762 Disintegrin dom InterPro 2.542E-22 1.271E-21 5.438E-21 1.017E-20 8 41
9 4.10.70.10 - Gene3D 3.860E-21 1.716E-20 7.340E-20 1.544E-19 7 20
10 PF00200 Disintegrin Pfam 5.790E-21 2.105E-20 9.008E-20 2.316E-19 7 21
11 SM00050 DISIN SMART 5.790E-21 2.105E-20 9.008E-20 2.316E-19 7 21
12 IPR006586 ADAM Cys-rich InterPro 4.420E-20 1.360E-19 5.819E-19 1.768E-18 7 27
13 SM00608 ACR SMART 4.420E-20 1.360E-19 5.819E-19 1.768E-18 7 27
14 IPR024079 MetalloPept cat dom InterPro 8.557E-20 2.282E-19 9.763E-19 3.423E-18 8 81
15 3.40.390.10 - Gene3D 8.557E-20 2.282E-19 9.763E-19 3.423E-18 8 81
16 PS00142 ZINC PROTEASE PROSITE 4.187E-19 1.047E-18 4.478E-18 1.675E-17 8 98
17 PF08516 ADAM CR Pfam 8.652E-18 2.036E-17 8.710E-17 3.461E-16 6 18
18 IPR018358 Disintegrin CS InterPro 1.271E-14 2.823E-14 1.208E-13 5.082E-13 5 16
19 IPR013032 EGF-like CS InterPro 7.635E-13 1.607E-12 6.877E-12 3.054E-11 7 262
20 IPR013111 EGF extracell InterPro 1.579E-11 3.008E-11 1.287E-10 6.317E-10 5 60
21 PF07974 EGF 2 Pfam 1.579E-11 3.008E-11 1.287E-10 6.317E-10 5 60
22 PS50026 EGF 3 PROSITE 1.028E-10 1.869E-10 7.998E-10 4.112E-9 6 236
23 IPR000742 EGF-like dom InterPro 1.456E-10 2.533E-10 1.084E-9 5.825E-9 6 250
24 PS00022 EGF 1 PROSITE 1.680E-10 2.801E-10 1.198E-9 6.721E-9 6 256
25 PS01186 EGF 2 PROSITE 2.117E-10 3.388E-10 1.450E-9 8.470E-9 6 266
26 PS00546 CYSTEINE SWITCH PROSITE 1.373E-9 2.112E-9 9.035E-9 5.491E-8 4 41
27 IPR001818 Pept M10 metallopeptidase InterPro 1.672E-9 2.477E-9 1.060E-8 6.689E-8 4 43
28 SM00181 EGF SMART 1.652E-6 2.359E-6 1.009E-5 6.606E-5 4 236
29 IPR013274 Pept M12B ADAM-TS1 InterPro 4.270E-4 5.176E-4 2.215E-3 1.708E-2 1 1
30 IPR033596 ADAM19 InterPro 4.270E-4 5.176E-4 2.215E-3 1.708E-2 1 1
31 IPR033605 ADAM15 InterPro 4.270E-4 5.176E-4 2.215E-3 1.708E-2 1 1
32 IPR032029 ADAM17 MPD InterPro 4.270E-4 5.176E-4 2.215E-3 1.708E-2 1 1
33 PF16698 ADAM17 MPD Pfam 4.270E-4 5.176E-4 2.215E-3 1.708E-2 1 1
34 PF05986 ADAM spacer1 Pfam 9.781E-3 1.118E-2 4.783E-2
3.912E-1
 1 23
35 IPR010294 ADAM spacer1 InterPro 9.781E-3 1.118E-2 4.783E-2
3.912E-1
 1 23
36 IPR013273 Peptidase M12B ADAM-TS InterPro 1.020E-2 1.134E-2 4.851E-2
4.082E-1
 1 24
37 PF00090 TSP 1 Pfam 2.659E-2 2.743E-2
1.173E-1
1.000E0
 1 63
38 SM00209 TSP1 SMART 2.743E-2 2.743E-2
1.173E-1
1.000E0
 1 65
39 PS50092 TSP1 PROSITE 2.743E-2 2.743E-2
1.173E-1
1.000E0
 1 65
40 IPR000884 TSP1 rpt InterPro 2.743E-2 2.743E-2
1.173E-1
1.000E0
 1 65
Show 35 more annotations

7: Pathway [Display Chart] 8 input genes in category / 50 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 1.587E-14 7.935E-13 3.570E-12 7.935E-13 8 238
2 1270257 Degradation of the extracellular matrix BioSystems: REACTOME 4.226E-7 1.056E-5 4.753E-5 2.113E-5 4 112
3 1270244 Extracellular matrix organization BioSystems: REACTOME 2.087E-5 3.479E-4 1.565E-3 1.044E-3 4 298
4 1270259 Collagen degradation BioSystems: REACTOME 2.926E-4 3.657E-3 1.646E-2 1.463E-2 2 41
5 P00003 Alzheimer disease-amyloid secretase pathway PantherDB 7.365E-4 7.365E-3 3.313E-2 3.682E-2 2 65
6 1268885 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant BioSystems: REACTOME 4.490E-3 3.207E-2
1.443E-1
2.245E-1
 1 7
7 1268884 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant BioSystems: REACTOME 4.490E-3 3.207E-2
1.443E-1
2.245E-1
 1 7
8 1269635 Release of Hh-Np from the secreting cell BioSystems: REACTOME 5.130E-3 3.207E-2
1.443E-1
2.565E-1
 1 8
9 1269459 Regulated proteolysis of p75NTR BioSystems: REACTOME 6.409E-3 3.429E-2
1.543E-1
3.205E-1
 1 10
10 PW:0000233 tumor necrosis factor mediated signaling Pathway Ontology 7.687E-3 3.429E-2
1.543E-1
3.844E-1
 1 12
11 M16173 Presenilin action in Notch and Wnt signaling MSigDB C2 BIOCARTA (v6.0) 8.963E-3 3.429E-2
1.543E-1
4.482E-1
 1 14
12 1268887 Constitutive Signaling by NOTCH1 HD Domain Mutants BioSystems: REACTOME 9.601E-3 3.429E-2
1.543E-1
4.800E-1
 1 15
13 1268886 Signaling by NOTCH1 HD Domain Mutants in Cancer BioSystems: REACTOME 9.601E-3 3.429E-2
1.543E-1
4.800E-1
 1 15
14 1270349 LGI-ADAM interactions BioSystems: REACTOME 9.601E-3 3.429E-2
1.543E-1
4.800E-1
 1 15
15 M7552 Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy MSigDB C2 BIOCARTA (v6.0) 1.151E-2 3.837E-2
1.726E-1
5.756E-1
 1 18
16 1269327 Growth hormone receptor signaling BioSystems: REACTOME 1.596E-2 4.693E-2
2.111E-1
7.978E-1
 1 25
17 1269499 Nuclear signaling by ERBB4 BioSystems: REACTOME 1.596E-2 4.693E-2
2.111E-1
7.978E-1
 1 25
18 1269536 Activated NOTCH1 Transmits Signal to the Nucleus BioSystems: REACTOME 1.975E-2 4.903E-2
2.206E-1
9.876E-1
 1 31
19 138064 Syndecan-4-mediated signaling events BioSystems: Pathway Interaction Database 1.975E-2 4.903E-2
2.206E-1
9.876E-1
 1 31
20 137991 ErbB4 signaling events BioSystems: Pathway Interaction Database 2.038E-2 4.903E-2
2.206E-1
1.000E0
 1 32
21 1269380 Signaling by EGFR BioSystems: REACTOME 2.157E-2 4.903E-2
2.206E-1
1.000E0
 2 367
22 PW:0000204 Notch signaling Pathway Ontology 2.228E-2 4.903E-2
2.206E-1
1.000E0
 1 35
23 1383054 Defective B3GALTL causes Peters-plus syndrome (PpS) BioSystems: REACTOME 2.354E-2 4.903E-2
2.206E-1
1.000E0
 1 37
24 P00045 Notch signaling pathway PantherDB 2.354E-2 4.903E-2
2.206E-1
1.000E0
 1 37
25 1268735 O-glycosylation of TSR domain-containing proteins BioSystems: REACTOME 2.479E-2 4.959E-2
2.231E-1
1.000E0
 1 39
26 1269496 Signaling by ERBB4 BioSystems: REACTOME 2.731E-2 4.988E-2
2.244E-1
1.000E0
 1 43
27 1269646 TNF signaling BioSystems: REACTOME 2.731E-2 4.988E-2
2.244E-1
1.000E0
 1 43
28 138053 TNF receptor signaling pathway BioSystems: Pathway Interaction Database 2.793E-2 4.988E-2
2.244E-1
1.000E0
 1 44
Show 23 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 1289 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15936750 Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2. Pubmed 8.271E-20 1.066E-16 8.251E-16 1.066E-16 5 5
2 15907280 Abundance of ADAM-8, -9, -10, -12, -15 and -17 and ADAMTS-1 in mouse uterus during the oestrous cycle. Pubmed 1.737E-18 1.119E-15 8.663E-15 2.239E-15 5 7
3 10527948 Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Pubmed 4.631E-18 1.492E-15 1.155E-14 5.969E-15 5 8
4 17344430 Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19. Pubmed 4.631E-18 1.492E-15 1.155E-14 5.969E-15 5 8
5 14993236 Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. Pubmed 3.948E-15 1.018E-12 7.877E-12 5.089E-12 4 5
6 15280379 ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. Pubmed 2.763E-14 5.936E-12 4.594E-11 3.562E-11 4 7
7 15063736 Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. Pubmed 3.057E-12 5.629E-10 4.356E-9 3.940E-9 4 19
8 7566181 A metalloprotease-disintegrin participating in myoblast fusion. Pubmed 6.031E-12 8.638E-10 6.685E-9 7.775E-9 3 3
9 19253070 ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study. Pubmed 6.031E-12 8.638E-10 6.685E-9 7.775E-9 3 3
10 16079176 Selective modulation of integrin-mediated cell migration by distinct ADAM family members. Pubmed 2.412E-11 2.827E-9 2.188E-8 3.110E-8 3 4
11 12615925 The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. Pubmed 2.412E-11 2.827E-9 2.188E-8 3.110E-8 3 4
12 19574220 Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9. Pubmed 6.030E-11 5.552E-9 4.297E-8 7.773E-8 3 5
13 17072319 ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Pubmed 6.030E-11 5.552E-9 4.297E-8 7.773E-8 3 5
14 24103556 Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Pubmed 6.030E-11 5.552E-9 4.297E-8 7.773E-8 3 5
15 10531379 Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. Pubmed 3.376E-10 2.720E-8 2.105E-7 4.352E-7 3 8
16 12777399 Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. Pubmed 3.376E-10 2.720E-8 2.105E-7 4.352E-7 3 8
17 19054571 Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Pubmed 2.442E-8 1.852E-6 1.433E-5 3.148E-5 3 30
18 23645517 Molecular profiling of ADAM12 and ADAM17 genes in human malignant melanoma. Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
19 23910172 Molecular implication of ADAM-15 and -17 in intrauterine adhesions. Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
20 9806848 Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
21 16495931 Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
22 26242473 ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function. Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
23 21501859 Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics. Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
24 21240579 ADAM12 and ADAM17 gene expression in laser-capture microdissected and non-microdissected breast tumors. Pubmed 3.839E-8 2.062E-6 1.596E-5 4.949E-5 2 2
25 24006456 Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Pubmed 8.498E-8 3.374E-6 2.611E-5 1.095E-4 4 228
26 19278423 The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
27 19003995 UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
28 12535668 Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
29 9016778 Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
30 19581512 Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
31 16806063 Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
32 19213735 ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
33 23429442 High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
34 24998958 Differential expression of ADAM (a disintegrin and metalloproteinase) genes between human first trimester villous and extravillous trophoblast cells. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
35 25795784 The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
36 27554339 ADAM9 silencing inhibits breast tumor cells transmigration through blood and lymphatic endothelial cells. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
37 9461614 Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
38 9622634 Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
39 8146185 A family of cellular proteins related to snake venom disintegrins. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
40 18393804 Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
41 17107962 Proteolytic processing of delta-like 1 by ADAM proteases. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
42 19564338 Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
43 15358598 ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
44 10523497 Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. Pubmed 1.152E-7 3.374E-6 2.611E-5 1.484E-4 2 3
45 9920899 Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. Pubmed 2.303E-7 6.597E-6 5.105E-5 2.969E-4 2 4
46 14516789 Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Pubmed 5.756E-7 1.546E-5 1.196E-4 7.420E-4 2 6
47 11882657 Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. Pubmed 5.756E-7 1.546E-5 1.196E-4 7.420E-4 2 6
48 23354118 Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Pubmed 5.756E-7 1.546E-5 1.196E-4 7.420E-4 2 6
49 12058067 Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Pubmed 8.058E-7 2.077E-5 1.608E-4 1.039E-3 2 7
50 14673146 Essential role for ADAM19 in cardiovascular morphogenesis. Pubmed 8.058E-7 2.077E-5 1.608E-4 1.039E-3 2 7
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 124 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SH3D19 SH3D19 interactions 4.063E-11 5.038E-9 2.721E-8 5.038E-9 4 17
2 int:MAD2L2 MAD2L2 interactions 2.153E-6 1.335E-4 7.211E-4 2.670E-4 3 61
3 int:SH3GL2 SH3GL2 interactions 3.269E-6 1.351E-4 7.298E-4 4.053E-4 3 70
4 int:SH3PXD2A SH3PXD2A interactions 8.485E-6 2.630E-4 1.421E-3 1.052E-3 3 96
5 int:ADAM32 ADAM32 interactions 4.500E-5 1.116E-3 6.028E-3 5.580E-3 2 23
6 int:FURIN FURIN interactions 1.181E-4 2.440E-3 1.318E-2 1.464E-2 2 37
7 int:TNFSF11 TNFSF11 interactions 1.382E-4 2.448E-3 1.322E-2 1.714E-2 2 40
8 int:INSL5 INSL5 interactions 2.434E-4 3.773E-3 2.038E-2 3.018E-2 2 53
9 int:SNX9 SNX9 interactions 3.122E-4 4.301E-3 2.323E-2 3.871E-2 2 60
10 int:PACSIN3 PACSIN3 interactions 3.664E-4 4.544E-3 2.454E-2 4.544E-2 2 65
11 int:MAD2L1 MAD2L1 interactions 5.971E-4 6.170E-3 3.333E-2
7.404E-2
 2 83
12 int:SH3GLB1 SH3GLB1 interactions 5.971E-4 6.170E-3 3.333E-2
7.404E-2
 2 83
13 int:A2M A2M interactions 1.263E-3 1.200E-2
6.483E-2
1.566E-1
 2 121
14 int:ADAM28 ADAM28 interactions 1.355E-3 1.200E-2
6.483E-2
1.680E-1
 1 3
15 int:YES1 YES1 interactions 1.478E-3 1.222E-2
6.599E-2
1.833E-1
 2 131
16 int:SYNGAP1 SYNGAP1 interactions 1.757E-3 1.318E-2
7.118E-2
2.179E-1
 2 143
17 int:PLA2G12B PLA2G12B interactions 1.807E-3 1.318E-2
7.118E-2
2.240E-1
 1 4
18 int:LGI1 LGI1 interactions 2.258E-3 1.555E-2
8.401E-2
2.800E-1
 1 5
19 int:SNX30 SNX30 interactions 2.709E-3 1.768E-2
9.549E-2
3.359E-1
 1 6
20 int:NAPSA NAPSA interactions 3.160E-3 1.781E-2
9.619E-2
3.918E-1
 1 7
21 int:DCHS1 DCHS1 interactions 3.160E-3 1.781E-2
9.619E-2
3.918E-1
 1 7
22 int:FSTL3 FSTL3 interactions 3.160E-3 1.781E-2
9.619E-2
3.918E-1
 1 7
23 int:USP17L9P USP17L9P interactions 4.061E-3 2.098E-2
1.133E-1
5.035E-1
 1 9
24 int:LRRC3 LRRC3 interactions 4.061E-3 2.098E-2
1.133E-1
5.035E-1
 1 9
25 int:ADAM19 ADAM19 interactions 4.511E-3 2.168E-2
1.171E-1
5.594E-1
 1 10
26 int:LYN LYN interactions 4.545E-3 2.168E-2
1.171E-1
5.636E-1
 2 232
27 int:IFNA8 IFNA8 interactions 5.411E-3 2.271E-2
1.227E-1
6.710E-1
 1 12
28 int:SDK2 SDK2 interactions 5.411E-3 2.271E-2
1.227E-1
6.710E-1
 1 12
29 int:CER1 CER1 interactions 5.861E-3 2.271E-2
1.227E-1
7.267E-1
 1 13
30 int:CLPSL1 CLPSL1 interactions 5.861E-3 2.271E-2
1.227E-1
7.267E-1
 1 13
31 int:VEGFD VEGFD interactions 5.861E-3 2.271E-2
1.227E-1
7.267E-1
 1 13
32 int:HPX HPX interactions 5.861E-3 2.271E-2
1.227E-1
7.267E-1
 1 13
33 int:ADAM12 ADAM12 interactions 6.310E-3 2.371E-2
1.281E-1
7.825E-1
 1 14
34 int:TNF TNF interactions 6.691E-3 2.395E-2
1.294E-1
8.297E-1
 2 283
35 int:ADAM22 ADAM22 interactions 6.760E-3 2.395E-2
1.294E-1
8.382E-1
 1 15
36 int:IFNA5 IFNA5 interactions 7.658E-3 2.566E-2
1.386E-1
9.496E-1
 1 17
37 int:SNX33 SNX33 interactions 7.658E-3 2.566E-2
1.386E-1
9.496E-1
 1 17
38 int:TGFA TGFA interactions 8.107E-3 2.578E-2
1.392E-1
1.000E0
 1 18
39 int:ACAN ACAN interactions 8.107E-3 2.578E-2
1.392E-1
1.000E0
 1 18
40 int:IGFBP5 IGFBP5 interactions 9.452E-3 2.740E-2
1.480E-1
1.000E0
 1 21
41 int:KLK2 KLK2 interactions 9.452E-3 2.740E-2
1.480E-1
1.000E0
 1 21
42 int:MAPK1 MAPK1 interactions 9.593E-3 2.740E-2
1.480E-1
1.000E0
 2 341
43 int:SP4 SP4 interactions 9.901E-3 2.740E-2
1.480E-1
1.000E0
 1 22
44 int:EGF EGF interactions 1.035E-2 2.740E-2
1.480E-1
1.000E0
 1 23
45 int:GPHA2 GPHA2 interactions 1.035E-2 2.740E-2
1.480E-1
1.000E0
 1 23
46 int:ADAMTS1 ADAMTS1 interactions 1.080E-2 2.740E-2
1.480E-1
1.000E0
 1 24
47 int:IGFBP1 IGFBP1 interactions 1.124E-2 2.740E-2
1.480E-1
1.000E0
 1 25
48 int:ITGA3 ITGA3 interactions 1.169E-2 2.740E-2
1.480E-1
1.000E0
 1 26
49 int:PRSS50 PRSS50 interactions 1.169E-2 2.740E-2
1.480E-1
1.000E0
 1 26
50 int:PTK6 PTK6 interactions 1.214E-2 2.740E-2
1.480E-1
1.000E0
 1 27
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21q21.2 21q21.2 1.845E-3 8.295E-3 2.254E-2 1.476E-2 1 8
2 7q21 7q21 2.997E-3 8.295E-3 2.254E-2 2.397E-2 1 13
3 8p11.22 8p11.22 3.227E-3 8.295E-3 2.254E-2 2.582E-2 1 14
4 2p25 2p25 4.147E-3 8.295E-3 2.254E-2 3.318E-2 1 18
5 8p21.2 8p21.2 6.215E-3 9.945E-3 2.703E-2 4.972E-2 1 27
6 5q33.3 5q33.3 8.280E-3 1.104E-2 3.000E-2
6.624E-2
 1 36
7 10q26.3 10q26.3 1.240E-2 1.417E-2 3.851E-2
9.918E-2
 1 54
8 1q21.3 1q21.3 2.692E-2 2.692E-2
7.315E-2
2.153E-1
 1 118
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 57 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 47 ADAM metallopeptidase domain containing genenames.org 5.427E-20 1.628E-19 2.985E-19 1.628E-19 7 27
2 50 ADAM metallopeptidases with thrombospondin type 1 motif genenames.org 8.326E-3 1.249E-2 2.290E-2 2.498E-2 1 19

13: Coexpression [Display Chart] 8 input genes in category / 1086 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18044827-Table2 Human Breast Bergamaschi08 278genes GeneSigDB 3.101E-16 3.368E-13 2.549E-12 3.368E-13 8 270
2 18435859-Table2 Mouse Breast Piechocki08 73genes GeneSigDB 5.949E-7 3.230E-4 2.445E-3 6.460E-4 3 52
3 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 5.717E-6 2.069E-3 1.566E-2 6.208E-3 4 398
4 M6757 Genes down-regulated in splenic CD 33D1+ dendritic cells versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.200E-5 5.972E-3 4.520E-2 2.389E-2 3 172
5 M3893 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 7.496E-3
5.673E-2
 3.748E-2 3 200
6 17575140-Table1 Human Prostate Verona07 41genes GeneSigDB 6.552E-5 1.186E-2
8.975E-2
7.116E-2
 2 36
7 19286929-SuppTable2e Mouse Lung Rangasamy09 57genes GeneSigDB 1.484E-4 2.287E-2
1.731E-1
1.611E-1
 2 54
8 18308945-Table2 Human StemCell Huang08 60genes MSCs GeneSigDB 1.833E-4 2.287E-2
1.731E-1
1.991E-1
 2 60
9 19137020-SuppTable2a Human StemCell Fukuzawa09 114genes GeneSigDB 1.895E-4 2.287E-2
1.731E-1
2.058E-1
 2 61
10 18435859-ShorterGeneList Mouse Breast Piechocki08 558genes GeneSigDB 2.244E-4 2.437E-2
1.844E-1
2.437E-1
 3 376
11 M2799 Genes down-regulated in primary keratinocytes from RB1 [Gene ID=5925] skin specific knockout mice. MSigDB C6: Oncogenic Signatures (v6.0) 8.064E-4 3.361E-2
2.544E-1
8.757E-1
 2 126
12 17206280-TableS1C Mouse Breast Park07 173genes GeneSigDB 8.580E-4 3.361E-2
2.544E-1
9.318E-1
 2 130
13 M463 Genes down-regulated in CD4 [GeneID=920] T cells: control versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 9.939E-4 3.361E-2
2.544E-1
1.000E0
 2 140
14 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.008E-3 3.361E-2
2.544E-1
1.000E0
 2 141
15 M2774 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of ALK [Gene ID=238] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.022E-3 3.361E-2
2.544E-1
1.000E0
 2 142
16 15260889-TableS2b Human Breast Dairkee04 202genes GeneSigDB 1.037E-3 3.361E-2
2.544E-1
1.000E0
 2 143
17 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.065E-3 3.361E-2
2.544E-1
1.000E0
 2 145
18 M8786 Genes up-regulated in peritoneal macrophages: untreated versus poly(IC). MSigDB C7: Immunologic Signatures (v6.0) 1.095E-3 3.361E-2
2.544E-1
1.000E0
 2 147
19 M2689 Genes down-regulated in C57MG cells (mammary epithelium) by over-expression of WNT1 [Gene ID=7471] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.460E-3 3.361E-2
2.544E-1
1.000E0
 2 170
20 M8175 Genes down-regulated in HEK293 cells expressing mutant NOD2 [GeneID=64127]: untreated versus muramyl dipeptide [PubChem=11620162] for 2h. MSigDB C7: Immunologic Signatures (v6.0) 1.725E-3 3.361E-2
2.544E-1
1.000E0
 2 185
21 M4961 Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.914E-3 3.361E-2
2.544E-1
1.000E0
 2 195
22 M4943 Genes up-regulated in comparison of B cells versus myeloid dendritic cells (mDC). MSigDB C7: Immunologic Signatures (v6.0) 1.914E-3 3.361E-2
2.544E-1
1.000E0
 2 195
23 M3077 Genes down-regulated in comparison of healthy CD4 [GeneID=920] T cells versus healthy CD19 [GeneID=920] B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 3.361E-2
2.544E-1
1.000E0
 2 196
24 M4954 Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 versus monocytes from influenza vaccinee at day 7. MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 3.361E-2
2.544E-1
1.000E0
 2 196
25 M4936 Genes up-regulated in comparison of B cells versus monocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 3.361E-2
2.544E-1
1.000E0
 2 196
26 M8610 Genes up-regulated in bone marrow-derived dendritic cells CSF2 [GeneID=1437] versus CSF2 [GeneID=1437] and low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v6.0) 1.953E-3 3.361E-2
2.544E-1
1.000E0
 2 197
27 M7666 Genes up-regulated in ex vivo follicular dendritic cells: peripheral lymph node versus Peyers patch. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.361E-2
2.544E-1
1.000E0
 2 198
28 M8676 Genes up-regulated in monocytes (24h): M. tuberculosis 19 kDa lipopeptide versus M. tuberculosis 19 kDa lipopeptide and muramyl dipeptide [PubChem=11620162]. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.361E-2
2.544E-1
1.000E0
 2 198
29 M8860 Genes up-regulated in lymphoid primed multipotent progenitors versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
30 M8672 Genes up-regulated in monocytes (6h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
31 M8399 Genes up-regulated in brain: microglia versus dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
32 M6507 Genes down-regulated in monocyte-derived dendritic cells: LGALS1 [GeneID=3956] versus vehicle. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
33 M8612 Genes down-regulated in bone marrow-derived dendritic cells: unstimulated versus low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
34 M8686 Genes down-regulated in monocytes (6h): muramyl dipeptide [PubChem=11620162] versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
35 M3627 Genes up-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after treatment with trichostatin A (TSA) [PubChem=5562]. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
36 M5001 Genes down-regulated in comparison of plasmacytoid dendritic cells (pDC) from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.361E-2
2.544E-1
1.000E0
 2 199
37 M8070 Genes down-regulated in thymic implants from fetal versus those from adult bone marrow. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
38 M7824 Genes down-regulated in common dendritic cells versus those cultured and untreated. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
39 M8327 Genes down-regulated in BCL6 [GeneID=604] high follicular helper T cells versus naïve T CD4 [GeneID=920] cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
40 M5915 Genes encoding components of apical junction complex. MSigDB H: Hallmark Gene Sets (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
41 M4297 Genes up-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] low T cells at. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
42 M6954 Genes down-regulated in plasmacytoit dendritic cells (4h): untreated versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
43 M8310 Genes up-regulated in naïve T cells: CD4 [GeneID=920] versus NK. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
44 M3847 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
45 M8290 Genes up-regulated in spleen B lymphocytes: wildtype versus lupus susceptibility locus Sle2c1. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
46 M9886 Genes up-regulated in CD4 [GeneID=920] T cells: unstimulated versus activated. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
47 M6477 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
48 M3913 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
49 M6432 Genes up-regulated in NKT cells versus B1 B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
50 M7522 Genes down-regulated in double positive thymocytes stimulated by anti-CD3: wildtype versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.361E-2
2.544E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 578 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney adult Mesangium Meis k2 1000 kidney adult Mesangium Meis k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.225E-6 2.442E-3 1.694E-2 2.442E-3 4 348
2 gudmap kidney P0 JuxtaGlom Ren1 k2 1000 kidney P0 JuxtaGlom Ren1 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.227E-5 6.436E-3 4.465E-2 1.287E-2 3 163
3 gudmap dev gonad e11.5 F ReproVasc Flk k3 500 dev gonad e11.5 F ReproVasc Flk k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.370E-4 2.640E-2
1.832E-1
7.920E-2
 2 49

15: Computational [Display Chart] 8 input genes in category / 72 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13268 MODULE 210 Genes in the cancer module 210. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.079E-6 7.767E-5 3.776E-4 7.767E-5 3 28
2 M19072 MODULE 562 MMPs. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.159E-4 4.171E-3 2.028E-2 8.342E-3 2 21
3 M19173 MODULE 280 Metal ion (zinc) binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.410E-4 1.298E-2
6.311E-2
 3.895E-2 2 45

16: MicroRNA [Display Chart] 8 input genes in category / 352 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-23a-3p:Functional MTI Functional MTI miRTarbase 2.237E-6 7.874E-4 5.073E-3 7.874E-4 3 249
2 hsa-miR-662:mirSVR lowEffct hsa-miR-662:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.296E-5 1.601E-3 1.031E-2 4.563E-3 3 448
3 hsa-miR-5580-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.364E-5 1.601E-3 1.031E-2 4.803E-3 2 51
4 hsa-miR-130a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.072E-5 6.485E-3 4.178E-2 3.193E-2 2 131
5 hsa-miR-23c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.211E-5 6.485E-3 4.178E-2 3.242E-2 2 132
6 hsa-miR-451b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.189E-4 6.978E-3 4.495E-2 4.187E-2 2 150
7 hsa-miR-33a-5p:Functional MTI Functional MTI miRTarbase 1.693E-4 8.512E-3
5.484E-2
5.959E-2
 2 179
8 hsa-miR-1909*:mirSVR highEffct hsa-miR-1909*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.578E-4 2.015E-2
1.298E-1
1.612E-1
 2 295
9 hsa-miR-23b-3p:Functional MTI Functional MTI miRTarbase 5.448E-4 2.131E-2
1.373E-1
1.918E-1
 2 322
10 hsa-miR-4520-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.963E-4 2.675E-2
1.723E-1
3.507E-1
 1 9
11 hsa-miR-4296:mirSVR highEffct hsa-miR-4296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.025E-3 2.675E-2
1.723E-1
3.609E-1
 2 443
12 hsa-miR-4265:mirSVR highEffct hsa-miR-4265:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.048E-3 2.675E-2
1.723E-1
3.690E-1
 2 448
13 hsa-miR-591:mirSVR highEffct hsa-miR-591:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.053E-3 2.675E-2
1.723E-1
3.706E-1
 2 449
14 hsa-miR-4322:mirSVR highEffct hsa-miR-4322:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.152E-3 2.675E-2
1.723E-1
4.056E-1
 2 470
15 hsa-miR-210:mirSVR lowEffct hsa-miR-210:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 1.246E-3 2.675E-2
1.723E-1
4.387E-1
 2 489
16 hsa-miR-661:mirSVR highEffct hsa-miR-661:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.261E-3 2.675E-2
1.723E-1
4.440E-1
 2 492
17 hsa-miR-518b:mirSVR lowEffct hsa-miR-518b:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.292E-3 2.675E-2
1.723E-1
4.548E-1
 2 498
18 hsa-miR-6854-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.992E-3 3.895E-2
2.509E-1
7.011E-1
 1 18
19 hsa-miR-126-3p.1:TargetScan hsa-miR-126-3p.1 TargetScan 2.655E-3 4.918E-2
3.169E-1
9.345E-1
 1 24
Show 14 more annotations

17: Drug [Display Chart] 8 input genes in category / 3361 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000351065 bu-b Stitch 8.270E-9 2.780E-5 2.417E-4 2.780E-5 4 77
2 CID000002299 AC1L1DD6 Stitch 2.491E-7 2.950E-4 2.566E-3 8.373E-4 4 179
3 2930 DN Etilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 3.369E-7 2.950E-4 2.566E-3 1.132E-3 4 193
4 6244 UP Hexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.511E-7 2.950E-4 2.566E-3 1.180E-3 4 195
5 CID003035404 Tapi Stitch 2.288E-6 1.538E-3 1.338E-2 7.689E-3 3 80
6 ctd:D014284 Triiodothyronine CTD 1.292E-5 6.984E-3
6.074E-2
 4.343E-2 4 483
7 CID005288446 AC1NRBJE Stitch 1.579E-5 6.984E-3
6.074E-2
5.307E-2
 3 152
8 6427 UP STOCK1N-35215; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.706E-5 6.984E-3
6.074E-2
9.095E-2
 3 182
9 5936 UP H-7 dihydrochloride; Up 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.274E-5 6.984E-3
6.074E-2
1.100E-1
 3 194
10 6059 DN Karakoline [39089-30-0]; Down 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.325E-5 6.984E-3
6.074E-2
1.117E-1
 3 195
11 4139 UP Nadolol [42200-33-9]; Up 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.325E-5 6.984E-3
6.074E-2
1.117E-1
 3 195
12 6428 UP C75; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.480E-5 6.984E-3
6.074E-2
1.170E-1
 3 198
13 5598 UP ICI 182,780; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.480E-5 6.984E-3
6.074E-2
1.170E-1
 3 198
14 6055 UP Myosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.480E-5 6.984E-3
6.074E-2
1.170E-1
 3 198
15 3574 DN Piperacetazine [3819-00-9]; Down 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.532E-5 6.984E-3
6.074E-2
1.187E-1
 3 199
16 3544 UP Meprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 3.532E-5 6.984E-3
6.074E-2
1.187E-1
 3 199
17 2989 DN Benzthiazide [91-33-8]; Down 200; 9.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 3.532E-5 6.984E-3
6.074E-2
1.187E-1
 3 199
18 CID000001318 1,10-phenanthroline Stitch 8.469E-5 1.581E-2
1.375E-1
2.847E-1
 3 267
19 ctd:D005944 Glucosamine CTD 1.356E-4 1.769E-2
1.539E-1
4.559E-1
 3 313
20 CID000024403 TSPP Stitch 1.697E-4 1.769E-2
1.539E-1
5.703E-1
 2 57
21 CID000119031 marimastat Stitch 2.417E-4 1.769E-2
1.539E-1
8.124E-1
 2 68
22 CID000005430 thiabendazole Stitch 3.020E-4 1.769E-2
1.539E-1
1.000E0
 2 76
23 CID010126803 hydroxamate deriv., 61 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
24 CID006914621 IK682 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
25 CID010150046 hydroxamate deriv., 67 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
26 CID009862812 hydroxamate deriv., 4 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
27 CID010172010 hydroxamate deriv., 52 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
28 CID009861547 2oi0 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
29 CID010194440 methyl (1S,2S)-1-[3-[(3,4-dichlorophenyl)methoxy]phenyl]-2-(hydroxycarbamoyl)cyclopropanecarboxylate Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
30 CID010236267 methyl (1R,2S)-2-(hydroxycarbamoyl)-1-(3-methoxyphenyl)cyclopropane-1-carboxylate Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
31 CID000041320 nM Dda Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
32 CID010215513 hydroxamate deriv., 60 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
33 CID005288615 1zxc Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
34 CID010237300 hydroxamate deriv., 57 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
35 CID011674794 CHEMBL272890 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
36 CID010236529 hydroxamate deriv., 66 Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
37 CID010151045 methyl 2-(hydroxycarbamoyl)-1-[[4-[(2-methyl-4-quinolyl)methoxy]phenyl]methyl]cyclopropanecarboxylate Stitch 3.502E-4 1.769E-2
1.539E-1
1.000E0
 1 1
38 CID000003045 didox Stitch 3.601E-4 1.769E-2
1.539E-1
1.000E0
 2 83
39 CID000003498 AC1L1G2K Stitch 3.689E-4 1.769E-2
1.539E-1
1.000E0
 2 84
40 CID005327338 inhibitor 49 Stitch 7.004E-4 1.769E-2
1.539E-1
1.000E0
 1 2
41 CID000004162 methyprylon Stitch 7.004E-4 1.769E-2
1.539E-1
1.000E0
 1 2
42 CID000072542 echinosporin Stitch 7.004E-4 1.769E-2
1.539E-1
1.000E0
 1 2
43 CID006102708 4-NH Stitch 7.004E-4 1.769E-2
1.539E-1
1.000E0
 1 2
44 CID000007219 indene Stitch 7.507E-4 1.769E-2
1.539E-1
1.000E0
 2 120
45 CID005494437 O-NO Stitch 7.885E-4 1.769E-2
1.539E-1
1.000E0
 2 123
46 CID000115098 trypanothione disulfide Stitch 1.019E-3 1.769E-2
1.539E-1
1.000E0
 2 140
47 CID000216470 GW3333 Stitch 1.050E-3 1.769E-2
1.539E-1
1.000E0
 1 3
48 ctd:C499807 (2R, 3S)-2-(((4-(2-butynyloxy)phenyl)sulfonyl)amino)-N,3-dihydroxybutanamide CTD 1.050E-3 1.769E-2
1.539E-1
1.000E0
 1 3
49 CID000001266 1ld8 Stitch 1.050E-3 1.769E-2
1.539E-1
1.000E0
 1 3
50 ctd:C484302 apratastat CTD 1.050E-3 1.769E-2
1.539E-1
1.000E0
 1 3
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 163 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1368683 Epithelioma DisGeNET BeFree 3.219E-4 1.341E-2
7.610E-2
5.248E-2
 3 298
2 cv:C1423873 Cone-rod dystrophy 9 Clinical Variations 4.937E-4 1.341E-2
7.610E-2
8.047E-2
 1 1
3 C0005758 Bulla DisGeNET Curated 4.937E-4 1.341E-2
7.610E-2
8.047E-2
 1 1
4 cv:C3280501 Inflammatory skin and bowel disease, neonatal 1 Clinical Variations 4.937E-4 1.341E-2
7.610E-2
8.047E-2
 1 1
5 C1423873 CONE-ROD DYSTROPHY 9 DisGeNET Curated 4.937E-4 1.341E-2
7.610E-2
8.047E-2
 1 1
6 OMIN:612775 CONE-ROD DYSTROPHY 9; CORD9 OMIM 4.937E-4 1.341E-2
7.610E-2
8.047E-2
 1 1
7 C0085655 Polymyositis DisGeNET Curated 6.285E-4 1.464E-2
8.304E-2
1.024E-1
 2 78
8 C1835664 TYLOSIS WITH ESOPHAGEAL CANCER DisGeNET Curated 9.871E-4 2.011E-2
1.141E-1
1.609E-1
 1 2
9 C0027121 Myositis DisGeNET Curated 1.479E-3 2.679E-2
1.520E-1
2.411E-1
 2 120
10 C3887486 Interstitial lung fibrosis DisGeNET BeFree 1.654E-3 2.697E-2
1.530E-1
2.697E-1
 2 127
11 C0264732 Cardiac dilatation DisGeNET BeFree 2.959E-3 4.104E-2
2.329E-1
4.823E-1
 1 6
12 C0239295 Candidiasis of the esophagus DisGeNET BeFree 3.451E-3 4.104E-2
2.329E-1
5.626E-1
 1 7
13 C0597048 Neurogenic hypertension DisGeNET BeFree 4.435E-3 4.104E-2
2.329E-1
7.230E-1
 1 9
14 C0020636 Congenital hypoplasia DisGeNET BeFree 4.435E-3 4.104E-2
2.329E-1
7.230E-1
 1 9
15 C0340293 Anterior myocardial infarction DisGeNET BeFree 4.435E-3 4.104E-2
2.329E-1
7.230E-1
 1 9
16 C0018932 Hematochezia DisGeNET Curated 4.435E-3 4.104E-2
2.329E-1
7.230E-1
 1 9
17 C0030578 Paronychia Inflammation DisGeNET Curated 4.927E-3 4.104E-2
2.329E-1
8.031E-1
 1 10
18 C0241157 pustule DisGeNET Curated 4.927E-3 4.104E-2
2.329E-1
8.031E-1
 1 10
19 C0542346 Pimples DisGeNET Curated 4.927E-3 4.104E-2
2.329E-1
8.031E-1
 1 10
20 C1282496 Metastasis from malignant tumor of prostate DisGeNET BeFree 5.308E-3 4.104E-2
2.329E-1
8.653E-1
 2 230
21 C0858617 Posterior subcapsular cataract DisGeNET Curated 5.419E-3 4.104E-2
2.329E-1
8.832E-1
 1 11
22 C0037286 Skin Neoplasms DisGeNET Curated 5.767E-3 4.104E-2
2.329E-1
9.400E-1
 2 240
23 C0936223 Metastatic Prostate Carcinoma DisGeNET BeFree 6.050E-3 4.104E-2
2.329E-1
9.862E-1
 2 246
24 C0263537 Onychogryposis DisGeNET Curated 6.892E-3 4.104E-2
2.329E-1
1.000E0
 1 14
25 C1859541 Variable degree of villous atrophy DisGeNET Curated 7.873E-3 4.104E-2
2.329E-1
1.000E0
 1 16
26 C0554101 Villous atrophy DisGeNET Curated 7.873E-3 4.104E-2
2.329E-1
1.000E0
 1 16
27 C2677378 Duodenal villous atrophy DisGeNET Curated 7.873E-3 4.104E-2
2.329E-1
1.000E0
 1 16
28 C1833058 Small intestine biopsy shows villous atrophy DisGeNET Curated 7.873E-3 4.104E-2
2.329E-1
1.000E0
 1 16
29 C4020747 Biopsy shows villous atrophy DisGeNET Curated 7.873E-3 4.104E-2
2.329E-1
1.000E0
 1 16
30 C0267456 Villous atrophy of intestine DisGeNET Curated 7.873E-3 4.104E-2
2.329E-1
1.000E0
 1 16
31 C0339063 Cellulitis of eyelid DisGeNET Curated 8.364E-3 4.104E-2
2.329E-1
1.000E0
 1 17
32 C0278828 Stage IV Bladder Cancer AJCC v6 DisGeNET BeFree 8.854E-3 4.104E-2
2.329E-1
1.000E0
 1 18
33 C0005741 Blepharitis DisGeNET Curated 9.343E-3 4.104E-2
2.329E-1
1.000E0
 1 19
34 C0271844 Parathyroid hyperplasia DisGeNET Curated 9.343E-3 4.104E-2
2.329E-1
1.000E0
 1 19
35 C0854985 Adenocarcinoma of lung, stage I DisGeNET BeFree 9.343E-3 4.104E-2
2.329E-1
1.000E0
 1 19
36 C1456868 Diabetic foot ulcer DisGeNET BeFree 9.833E-3 4.104E-2
2.329E-1
1.000E0
 1 20
37 C0275544 Congenital infectious disease DisGeNET BeFree 9.833E-3 4.104E-2
2.329E-1
1.000E0
 1 20
38 C0683381 inflammatory joint disease DisGeNET BeFree 9.833E-3 4.104E-2
2.329E-1
1.000E0
 1 20
39 C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 9.941E-3 4.104E-2
2.329E-1
1.000E0
 2 318
40 C0333297 Chronic ulcer DisGeNET BeFree 1.032E-2 4.104E-2
2.329E-1
1.000E0
 1 21
41 C4072827 Cone/cone-rod dystrophy DisGeNET Curated 1.032E-2 4.104E-2
2.329E-1
1.000E0
 1 21
42 C1956089 Osteophyte DisGeNET BeFree 1.081E-2 4.196E-2
2.381E-1
1.000E0
 1 22
43 C0278493 Breast cancer recurrent DisGeNET BeFree 1.374E-2 4.990E-2
2.831E-1
1.000E0
 1 28
44 C1708565 Invasive Skin Melanoma DisGeNET BeFree 1.374E-2 4.990E-2
2.831E-1
1.000E0
 1 28
45 C0740457 Malignant neoplasm of kidney DisGeNET BeFree 1.378E-2 4.990E-2
2.831E-1
1.000E0
 2 377
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