Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc94_46, positive side

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1: GO: Molecular Function [Display Chart] 46 input genes in category / 116 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0018169 ribosomal S6-glutamic acid ligase activity 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
2 GO:0070735 protein-glycine ligase activity 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
3 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
4 GO:0070736 protein-glycine ligase activity, initiating 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
5 GO:0043774 coenzyme F420-2 alpha-glutamyl ligase activity 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
6 GO:0070738 tubulin-glycine ligase activity 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
7 GO:0070737 protein-glycine ligase activity, elongating 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
8 GO:0043773 coenzyme F420-0 gamma-glutamyl ligase activity 9.872E-71 1.431E-69 7.637E-69 1.145E-68 40 242
9 GO:0070740 tubulin-glutamic acid ligase activity 1.688E-70 2.175E-69 1.160E-68 1.958E-68 40 245
10 GO:0070739 protein-glutamic acid ligase activity 2.403E-70 2.788E-69 1.487E-68 2.788E-68 40 247
11 GO:0016881 acid-amino acid ligase activity 1.344E-69 1.418E-68 7.564E-68 1.560E-67 40 257
12 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3.805E-67 3.678E-66 1.962E-65 4.414E-65 40 293
13 GO:0016874 ligase activity 9.530E-61 8.504E-60 4.537E-59 1.106E-58 40 415
14 GO:0004842 ubiquitin-protein transferase activity 2.070E-51 1.715E-50 9.152E-50 2.402E-49 36 414
15 GO:0019787 ubiquitin-like protein transferase activity 2.190E-50 1.693E-49 9.035E-49 2.540E-48 36 441
16 GO:0061630 ubiquitin protein ligase activity 3.381E-31 2.451E-30 1.308E-29 3.922E-29 22 212
17 GO:0061659 ubiquitin-like protein ligase activity 5.765E-31 3.933E-30 2.099E-29 6.687E-29 22 217
18 GO:0031624 ubiquitin conjugating enzyme binding 1.255E-6 8.086E-6 4.314E-5 1.455E-4 4 33
19 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1.796E-6 1.097E-5 5.851E-5 2.084E-4 4 36
20 GO:0031625 ubiquitin protein ligase binding 4.365E-6 2.531E-5 1.351E-4 5.063E-4 7 273
21 GO:0044389 ubiquitin-like protein ligase binding 4.802E-6 2.653E-5 1.415E-4 5.571E-4 7 277
22 GO:0071535 RING-like zinc finger domain binding 3.556E-5 1.875E-4 1.000E-3 4.124E-3 2 4
23 GO:0051219 phosphoprotein binding 4.033E-5 2.034E-4 1.085E-3 4.679E-3 4 78
24 GO:0032184 SUMO polymer binding 8.861E-5 4.283E-4 2.285E-3 1.028E-2 2 6
25 GO:0050681 androgen receptor binding 1.399E-4 6.493E-4 3.464E-3 1.623E-2 3 41
26 GO:1990381 ubiquitin-specific protease binding 3.862E-4 1.723E-3 9.193E-3 4.480E-2 2 12
27 GO:0032183 SUMO binding 6.116E-4 2.627E-3 1.402E-2
7.094E-2
 2 15
28 GO:0002039 p53 binding 7.422E-4 3.075E-3 1.640E-2
8.609E-2
 3 72
29 GO:1990841 promoter-specific chromatin binding 7.896E-4 3.159E-3 1.685E-2
9.160E-2
 2 17
30 GO:0001784 phosphotyrosine residue binding 8.869E-4 3.430E-3 1.830E-2
1.029E-1
 2 18
31 GO:0003713 transcription coactivator activity 9.611E-4 3.597E-3 1.919E-2
1.115E-1
 5 310
32 GO:0035258 steroid hormone receptor binding 1.373E-3 4.975E-3 2.654E-2
1.592E-1
 3 89
33 GO:0045309 protein phosphorylated amino acid binding 2.157E-3 7.583E-3 4.046E-2
2.502E-1
 2 28
34 GO:0005164 tumor necrosis factor receptor binding 2.990E-3 1.020E-2
5.442E-2
3.468E-1
 2 33
35 GO:0032182 ubiquitin-like protein binding 3.775E-3 1.251E-2
6.675E-2
4.379E-1
 3 127
36 GO:0005135 interleukin-3 receptor binding 4.924E-3 1.587E-2
8.465E-2
5.712E-1
 1 2
37 GO:0032813 tumor necrosis factor receptor superfamily binding 6.754E-3 2.118E-2
1.130E-1
7.835E-1
 2 50
38 GO:0035257 nuclear hormone receptor binding 7.293E-3 2.139E-2
1.141E-1
8.459E-1
 3 161
39 GO:0035851 Krueppel-associated box domain binding 7.377E-3 2.139E-2
1.141E-1
8.558E-1
 1 3
40 GO:0005128 erythropoietin receptor binding 7.377E-3 2.139E-2
1.141E-1
8.558E-1
 1 3
41 GO:0019788 NEDD8 transferase activity 9.825E-3 2.590E-2
1.382E-1
1.000E0
 1 4
42 GO:0033142 progesterone receptor binding 9.825E-3 2.590E-2
1.382E-1
1.000E0
 1 4
43 GO:1904288 BAT3 complex binding 9.825E-3 2.590E-2
1.382E-1
1.000E0
 1 4
44 GO:0034056 estrogen response element binding 9.825E-3 2.590E-2
1.382E-1
1.000E0
 1 4
45 GO:0051427 hormone receptor binding 1.034E-2 2.665E-2
1.422E-1
1.000E0
 3 183
46 GO:0070087 chromo shadow domain binding 1.470E-2 3.707E-2
1.978E-1
1.000E0
 1 6
47 GO:0046332 SMAD binding 1.547E-2 3.818E-2
2.037E-1
1.000E0
 2 77
48 GO:0051087 chaperone binding 1.742E-2 4.210E-2
2.246E-1
1.000E0
 2 82
49 GO:0031386 protein tag 1.955E-2 4.629E-2
2.470E-1
1.000E0
 1 8
Show 44 more annotations

2: GO: Biological Process [Display Chart] 46 input genes in category / 948 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051865 protein autoubiquitination 5.948E-13 3.908E-10 2.905E-9 5.639E-10 8 53
2 GO:0000209 protein polyubiquitination 8.245E-13 3.908E-10 2.905E-9 7.816E-10 12 254
3 GO:0010498 proteasomal protein catabolic process 1.785E-11 5.639E-9 4.191E-8 1.692E-8 13 422
4 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 2.211E-9 5.241E-7 3.895E-6 2.096E-6 11 393
5 GO:0051090 regulation of DNA-binding transcription factor activity 3.394E-8 6.435E-6 4.783E-5 3.218E-5 10 395
6 GO:0051091 positive regulation of DNA-binding transcription factor activity 1.444E-7 2.281E-5 1.696E-4 1.369E-4 8 247
7 GO:0010390 histone monoubiquitination 2.787E-7 3.774E-5 2.805E-4 2.642E-4 4 23
8 GO:1902186 regulation of viral release from host cell 1.114E-6 1.320E-4 9.807E-4 1.056E-3 4 32
9 GO:0019076 viral release from host cell 1.811E-6 1.907E-4 1.418E-3 1.717E-3 4 36
10 GO:0035518 histone H2A monoubiquitination 3.055E-6 2.659E-4 1.976E-3 2.896E-3 3 12
11 GO:0016574 histone ubiquitination 3.085E-6 2.659E-4 1.976E-3 2.925E-3 4 41
12 GO:0036353 histone H2A-K119 monoubiquitination 5.969E-6 4.715E-4 3.505E-3 5.659E-3 2 2
13 GO:1902187 negative regulation of viral release from host cell 9.361E-6 6.373E-4 4.737E-3 8.874E-3 3 17
14 GO:0006513 protein monoubiquitination 9.412E-6 6.373E-4 4.737E-3 8.922E-3 4 54
15 GO:0033522 histone H2A ubiquitination 1.329E-5 8.401E-4 6.244E-3 1.260E-2 3 19
16 GO:0051092 positive regulation of NF-kappaB transcription factor activity 2.391E-5 1.333E-3 9.910E-3 2.267E-2 5 140
17 GO:0016925 protein sumoylation 2.391E-5 1.333E-3 9.910E-3 2.267E-2 5 140
18 GO:0032897 negative regulation of viral transcription 2.753E-5 1.450E-3 1.077E-2 2.610E-2 3 24
19 GO:0045732 positive regulation of protein catabolic process 4.853E-5 2.422E-3 1.800E-2 4.601E-2 6 268
20 GO:0009896 positive regulation of catabolic process 6.458E-5 3.061E-3 2.275E-2
6.123E-2
 7 414
21 GO:1903320 regulation of protein modification by small protein conjugation or removal 7.514E-5 3.346E-3 2.487E-2
7.123E-2
 6 290
22 GO:1903901 negative regulation of viral life cycle 7.765E-5 3.346E-3 2.487E-2
7.361E-2
 4 92
23 GO:0048525 negative regulation of viral process 8.800E-5 3.627E-3 2.696E-2
8.342E-2
 4 95
24 GO:1901800 positive regulation of proteasomal protein catabolic process 9.543E-5 3.769E-3 2.801E-2
9.046E-2
 4 97
25 GO:0031398 positive regulation of protein ubiquitination 9.987E-5 3.787E-3 2.814E-2
9.467E-2
 5 189
26 GO:1903364 positive regulation of cellular protein catabolic process 1.129E-4 4.117E-3 3.060E-2
1.070E-1
 5 194
27 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 1.496E-4 5.251E-3 3.903E-2
1.418E-1
 5 206
28 GO:0070534 protein K63-linked ubiquitination 1.861E-4 6.301E-3 4.683E-2
1.764E-1
 3 45
29 GO:0035372 protein localization to microtubule 2.125E-4 6.834E-3
5.079E-2
2.015E-1
 2 9
30 GO:0031331 positive regulation of cellular catabolic process 2.163E-4 6.834E-3
5.079E-2
2.050E-1
 6 352
31 GO:0070936 protein K48-linked ubiquitination 2.400E-4 7.338E-3
5.454E-2
2.275E-1
 3 49
32 GO:0046782 regulation of viral transcription 4.591E-4 1.360E-2
1.011E-1
4.353E-1
 3 61
33 GO:0031396 regulation of protein ubiquitination 4.947E-4 1.421E-2
1.056E-1
4.690E-1
 5 267
34 GO:0042176 regulation of protein catabolic process 5.138E-4 1.433E-2
1.065E-1
4.871E-1
 6 414
35 GO:0030521 androgen receptor signaling pathway 5.534E-4 1.499E-2
1.114E-1
5.246E-1
 3 65
36 GO:1903362 regulation of cellular protein catabolic process 6.862E-4 1.807E-2
1.343E-1
6.506E-1
 5 287
37 GO:0071383 cellular response to steroid hormone stimulus 7.192E-4 1.843E-2
1.369E-1
6.818E-1
 5 290
38 GO:0043901 negative regulation of multi-organism process 7.422E-4 1.852E-2
1.376E-1
7.036E-1
 4 166
39 GO:0030522 intracellular receptor signaling pathway 8.251E-4 2.006E-2
1.491E-1
7.822E-1
 5 299
40 GO:1903900 regulation of viral life cycle 9.231E-4 2.188E-2
1.626E-1
8.751E-1
 4 176
41 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 1.003E-3 2.320E-2
1.724E-1
9.512E-1
 4 180
42 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 1.129E-3 2.507E-2
1.863E-1
1.000E0
 3 83
43 GO:0061136 regulation of proteasomal protein catabolic process 1.202E-3 2.507E-2
1.863E-1
1.000E0
 4 189
44 GO:0050792 regulation of viral process 1.202E-3 2.507E-2
1.863E-1
1.000E0
 4 189
45 GO:0060333 interferon-gamma-mediated signaling pathway 1.209E-3 2.507E-2
1.863E-1
1.000E0
 3 85
46 GO:0002643 regulation of tolerance induction 1.217E-3 2.507E-2
1.863E-1
1.000E0
 2 21
47 GO:0007389 pattern specification process 1.300E-3 2.623E-2
1.949E-1
1.000E0
 6 495
48 GO:0046597 negative regulation of viral entry into host cell 1.461E-3 2.886E-2
2.145E-1
1.000E0
 2 23
49 GO:0044033 multi-organism metabolic process 1.679E-3 3.249E-2
2.415E-1
1.000E0
 4 207
50 GO:0060765 regulation of androgen receptor signaling pathway 1.727E-3 3.274E-2
2.434E-1
1.000E0
 2 25
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 46 input genes in category / 116 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000151 ubiquitin ligase complex 1.835E-15 2.129E-13 1.136E-12 2.129E-13 14 274
2 GO:0000152 nuclear ubiquitin ligase complex 5.207E-8 3.020E-6 1.611E-5 6.040E-6 5 42
3 GO:0035102 PRC1 complex 2.850E-6 1.102E-4 5.879E-4 3.306E-4 3 12
4 GO:0031519 PcG protein complex 4.114E-6 1.193E-4 6.364E-4 4.772E-4 4 45
5 GO:0016604 nuclear body 2.465E-5 5.718E-4 3.051E-3 2.859E-3 7 364
6 GO:0000836 Hrd1p ubiquitin ligase complex 5.671E-5 9.458E-4 5.046E-3 6.579E-3 2 5
7 GO:0000792 heterochromatin 5.707E-5 9.458E-4 5.046E-3 6.620E-3 4 87
8 GO:0000835 ER ubiquitin ligase complex 8.494E-5 1.232E-3 6.571E-3 9.853E-3 2 6
9 GO:0001739 sex chromatin 1.187E-4 1.416E-3 7.555E-3 1.377E-2 2 7
10 GO:0000791 euchromatin 1.221E-4 1.416E-3 7.555E-3 1.416E-2 3 40
11 GO:0005720 nuclear heterochromatin 1.414E-4 1.491E-3 7.953E-3 1.640E-2 3 42
12 GO:0036513 Derlin-1 retrotranslocation complex 3.091E-4 2.758E-3 1.471E-2 3.585E-2 2 11
13 GO:0035631 CD40 receptor complex 3.091E-4 2.758E-3 1.471E-2 3.585E-2 2 11
14 GO:0000153 cytoplasmic ubiquitin ligase complex 5.864E-4 4.859E-3 2.592E-2
6.802E-2
 2 15
15 GO:0016607 nuclear speck 1.385E-3 1.071E-2
5.715E-2
1.607E-1
 4 201
16 GO:0005719 nuclear euchromatin 2.374E-3 1.647E-2
8.785E-2
2.754E-1
 2 30
17 GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex 2.413E-3 1.647E-2
8.785E-2
2.799E-1
 1 1
18 GO:0000803 sex chromosome 2.699E-3 1.739E-2
9.279E-2
3.131E-1
 2 32
19 GO:0033768 SUMO-targeted ubiquitin ligase complex 4.821E-3 2.796E-2
1.492E-1
5.592E-1
 1 2
20 GO:0043224 nuclear SCF ubiquitin ligase complex 4.821E-3 2.796E-2
1.492E-1
5.592E-1
 1 2
21 GO:0000785 chromatin 6.173E-3 3.410E-2
1.819E-1
7.161E-1
 5 487
22 GO:0000790 nuclear chromatin 7.629E-3 4.022E-2
2.146E-1
8.849E-1
 4 324
Show 17 more annotations

4: Human Phenotype [Display Chart] 10 input genes in category / 243 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 36 input genes in category / 812 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005004 abnormal lymphocyte anergy 8.310E-6 6.748E-3 4.910E-2 6.748E-3 3 12
2 MP:0008687 increased interleukin-2 secretion 3.973E-5 1.613E-2
1.174E-1
 3.226E-2 4 56
3 MP:0008747 abnormal T cell anergy 1.747E-4 4.730E-2
3.442E-1
1.419E-1
 2 6

6: Domain [Display Chart] 46 input genes in category / 207 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001841 Znf RING InterPro 1.322E-79 2.737E-77 1.618E-76 2.737E-77 45 326
2 PS50089 ZF RING 2 PROSITE 2.773E-78 2.870E-76 1.697E-75 5.739E-76 44 298
3 SM00184 RING SMART 8.343E-78 5.757E-76 3.403E-75 1.727E-75 44 305
4 PS00518 ZF RING 1 PROSITE 9.772E-76 5.057E-74 2.990E-73 2.023E-73 43 291
5 PF00097 zf-C3HC4 Pfam 3.415E-75 1.414E-73 8.360E-73 7.070E-73 41 223
6 IPR013083 Znf RING/FYVE/PHD InterPro 1.645E-69 5.674E-68 3.354E-67 3.404E-67 44 459
7 3.30.40.10 - Gene3D 3.930E-67 1.162E-65 6.871E-65 8.135E-65 43 449
8 IPR018957 Znf C3HC4 RING-type InterPro 1.865E-53 4.827E-52 2.854E-51 3.861E-51 31 172
9 IPR017907 Znf RING CS InterPro 4.386E-47 1.009E-45 5.964E-45 9.078E-45 28 163
10 SM00336 BBOX SMART 6.404E-22 1.326E-20 7.838E-20 1.326E-19 13 69
11 4.10.45.10 - Gene3D 9.596E-22 1.806E-20 1.068E-19 1.986E-19 13 71
12 PF00643 zf-B box Pfam 1.169E-21 2.017E-20 1.192E-19 2.420E-19 13 72
13 PS50119 ZF BBOX PROSITE 5.128E-21 8.166E-20 4.828E-19 1.062E-18 13 80
14 IPR000315 Znf B-box InterPro 6.099E-21 9.017E-20 5.331E-19 1.262E-18 13 81
15 PF13639 zf-RING 2 Pfam 3.012E-19 4.157E-18 2.458E-17 6.236E-17 11 52
16 SM00502 BBC SMART 4.411E-18 5.371E-17 3.175E-16 9.131E-16 8 15
17 IPR003649 Bbox C InterPro 4.411E-18 5.371E-17 3.175E-16 9.131E-16 8 15
18 PS51262 COS PROSITE 1.552E-8 1.690E-7 9.994E-7 3.212E-6 4 12
19 IPR017903 COS domain InterPro 1.552E-8 1.690E-7 9.994E-7 3.212E-6 4 12
20 PF13445 zf-RING UBOX Pfam 1.882E-8 1.855E-7 1.097E-6 3.895E-6 5 34
21 IPR027370 Znf-RING LisH InterPro 1.882E-8 1.855E-7 1.097E-6 3.895E-6 5 34
22 SM00449 SPRY SMART 6.794E-8 6.393E-7 3.780E-6 1.406E-5 6 87
23 IPR003877 SPRY dom InterPro 1.082E-7 9.174E-7 5.424E-6 2.239E-5 6 94
24 PF00622 SPRY Pfam 1.082E-7 9.174E-7 5.424E-6 2.239E-5 6 94
25 IPR001870 B30.2/SPRY InterPro 1.152E-7 9.174E-7 5.424E-6 2.385E-5 6 95
26 PS50188 B302 SPRY PROSITE 1.152E-7 9.174E-7 5.424E-6 2.385E-5 6 95
27 IPR003879 Butyrophylin InterPro 7.664E-7 5.876E-6 3.474E-5 1.586E-4 5 70
28 SM00589 PRY SMART 5.718E-6 4.081E-5 2.413E-4 1.184E-3 4 48
29 IPR006574 PRY InterPro 5.718E-6 4.081E-5 2.413E-4 1.184E-3 4 48
30 IPR013320 ConA-like dom InterPro 1.510E-5 9.142E-5 5.405E-4 3.126E-3 6 219
31 PS51506 CBL PTB PROSITE 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
32 IPR014741 Adaptor Cbl EF hand-like InterPro 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
33 PF02762 Cbl N3 Pfam 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
34 1.20.930.20 - Gene3D 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
35 IPR024159 Cbl PTB InterPro 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
36 IPR014742 Adaptor Cbl SH2-like InterPro 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
37 IPR024162 Adaptor Cbl InterPro 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
38 IPR003153 Adaptor Cbl N hlx InterPro 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
39 PF02262 Cbl N Pfam 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
40 PF02761 Cbl N2 Pfam 1.767E-5 9.142E-5 5.405E-4 3.657E-3 2 3
41 IPR008974 TRAF-like InterPro 2.704E-5 1.365E-4 8.072E-4 5.598E-3 3 24
42 IPR020457 Znf B-box chordata InterPro 3.528E-5 1.739E-4 1.028E-3 7.302E-3 2 4
43 PS00633 BROMODOMAIN 1 PROSITE 1.015E-4 4.887E-4 2.889E-3 2.101E-2 3 37
44 IPR032443 RAWUL InterPro 1.229E-4 5.653E-4 3.342E-3 2.544E-2 2 7
45 PF16207 RAWUL Pfam 1.229E-4 5.653E-4 3.342E-3 2.544E-2 2 7
46 PS50014 BROMODOMAIN 2 PROSITE 1.383E-4 6.156E-4 3.640E-3 2.863E-2 3 41
47 IPR001487 Bromodomain InterPro 1.487E-4 6.156E-4 3.640E-3 3.078E-2 3 42
48 SM00297 BROMO SMART 1.487E-4 6.156E-4 3.640E-3 3.078E-2 3 42
49 1.20.920.10 - Gene3D 1.487E-4 6.156E-4 3.640E-3 3.078E-2 3 42
50 PF13765 PRY Pfam 1.487E-4 6.156E-4 3.640E-3 3.078E-2 3 42
Show 45 more annotations

7: Pathway [Display Chart] 42 input genes in category / 258 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269193 Antigen processing: Ubiquitination & Proteasome degradation BioSystems: REACTOME 6.330E-17 1.633E-14 1.001E-13 1.633E-14 17 314
2 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 1.293E-15 1.667E-13 1.022E-12 3.335E-13 17 376
3 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 2.038E-11 1.753E-9 1.075E-8 5.258E-9 10 137
4 1269314 Interferon gamma signaling BioSystems: REACTOME 1.503E-5 9.697E-4 5.946E-3 3.879E-3 5 94
5 P04392 P53 pathway feedback loops 1 PantherDB 2.308E-4 1.101E-2
6.753E-2
5.955E-2
 2 7
6 1427863 Ovarian tumor domain proteases BioSystems: REACTOME 2.561E-4 1.101E-2
6.753E-2
6.608E-2
 3 37
7 1339112 SUMOylation of RNA binding proteins BioSystems: REACTOME 5.556E-4 1.802E-2
1.105E-1
1.433E-1
 3 48
8 1269311 Interferon Signaling BioSystems: REACTOME 5.588E-4 1.802E-2
1.105E-1
1.442E-1
 5 202
9 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 9.682E-4 2.626E-2
1.610E-1
2.498E-1
 3 58
10 138067 p53 pathway BioSystems: Pathway Interaction Database 1.018E-3 2.626E-2
1.610E-1
2.626E-1
 3 59
11 PW:0000718 p53 signaling pathway Pathway Ontology 1.294E-3 3.035E-2
1.861E-1
3.338E-1
 2 16
12 1268744 SUMOylation of DNA damage response and repair proteins BioSystems: REACTOME 2.278E-3 4.880E-2
2.993E-1
5.878E-1
 3 78
13 1268724 ER Quality Control Compartment (ERQC) BioSystems: REACTOME 2.459E-3 4.880E-2
2.993E-1
6.344E-1
 2 22
14 1269529 Downregulation of SMAD2/3:SMAD4 transcriptional activity BioSystems: REACTOME 2.687E-3 4.952E-2
3.037E-1
6.933E-1
 2 23
Show 9 more annotations

8: Pubmed [Display Chart] 46 input genes in category / 3992 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19549727 Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Pubmed 3.641E-44 1.453E-40 1.289E-39 1.453E-40 23 147
2 22493164 Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Pubmed 1.297E-42 2.590E-39 2.297E-38 5.179E-39 21 105
3 19690564 A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Pubmed 1.921E-41 2.556E-38 2.267E-37 7.667E-38 21 118
4 28786561 Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. Pubmed 4.958E-26 4.948E-23 4.388E-22 1.979E-22 15 138
5 11331580 The tripartite motif family identifies cell compartments. Pubmed 4.770E-24 3.216E-21 2.852E-20 1.904E-20 11 40
6 23105109 Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. Pubmed 4.959E-24 3.216E-21 2.852E-20 1.980E-20 12 63
7 29643511 Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Pubmed 5.638E-24 3.216E-21 2.852E-20 2.251E-20 13 95
8 21143188 Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Pubmed 2.646E-15 1.320E-12 1.171E-11 1.056E-11 7 28
9 24722188 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Pubmed 4.136E-11 1.835E-8 1.627E-7 1.651E-7 10 400
10 12096914 Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. Pubmed 1.635E-9 6.527E-7 5.789E-6 6.527E-6 3 3
11 23077300 TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. Pubmed 5.564E-9 1.863E-6 1.653E-5 2.221E-5 4 18
12 21531907 Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Pubmed 6.534E-9 1.863E-6 1.653E-5 2.608E-5 3 4
13 27832544 In Vitro Assay to Study Histone Ubiquitination During Transcriptional Regulation. Pubmed 6.534E-9 1.863E-6 1.653E-5 2.608E-5 3 4
14 16751658 Role of Bmi1 in H2A ubiquitylation and Hox gene silencing. Pubmed 6.534E-9 1.863E-6 1.653E-5 2.608E-5 3 4
15 25590999 The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Pubmed 1.085E-8 2.708E-6 2.402E-5 4.333E-5 4 21
16 18248090 TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Pubmed 1.085E-8 2.708E-6 2.402E-5 4.333E-5 4 21
17 16710298 Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. Pubmed 1.632E-8 3.429E-6 3.042E-5 6.516E-5 3 5
18 10022127 TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. Pubmed 1.632E-8 3.429E-6 3.042E-5 6.516E-5 3 5
19 12167161 MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. Pubmed 1.632E-8 3.429E-6 3.042E-5 6.516E-5 3 5
20 25470042 TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Pubmed 5.703E-8 1.084E-5 9.615E-5 2.277E-4 3 7
21 20800574 Regulation of the Polycomb protein RING1B ubiquitination by USP7. Pubmed 5.703E-8 1.084E-5 9.615E-5 2.277E-4 3 7
22 20864041 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Pubmed 6.459E-8 1.172E-5 1.039E-4 2.578E-4 4 32
23 22907436 Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation. Pubmed 9.117E-8 1.516E-5 1.345E-4 3.640E-4 3 8
24 23086935 Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. Pubmed 9.117E-8 1.516E-5 1.345E-4 3.640E-4 3 8
25 27107014 An inter-species protein-protein interaction network across vast evolutionary distance. Pubmed 1.057E-7 1.688E-5 1.497E-4 4.220E-4 8 483
26 22902369 BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer. Pubmed 1.366E-7 2.020E-5 1.792E-4 5.455E-4 3 9
27 27154519 Long noncoding RNA uc.338 promotes cell proliferation through association with BMI1 in hepatocellular carcinoma. Pubmed 1.366E-7 2.020E-5 1.792E-4 5.455E-4 3 9
28 12183370 Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Pubmed 2.680E-7 3.688E-5 3.271E-4 1.070E-3 3 11
29 28073915 UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119. Pubmed 2.680E-7 3.688E-5 3.271E-4 1.070E-3 3 11
30 15009096 Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. Pubmed 3.162E-7 4.207E-5 3.731E-4 1.262E-3 4 47
31 19636380 Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. Pubmed 3.570E-7 4.597E-5 4.077E-4 1.425E-3 3 12
32 27647897 BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin. Pubmed 4.637E-7 5.784E-5 5.130E-4 1.851E-3 3 13
33 27626314 The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer. Pubmed 5.896E-7 7.133E-5 6.326E-4 2.354E-3 3 14
34 20601937 Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. Pubmed 7.364E-7 8.646E-5 7.669E-4 2.940E-3 3 15
35 12167701 The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Pubmed 9.056E-7 9.770E-5 8.666E-4 3.615E-3 3 16
36 12589020 Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Pubmed 9.056E-7 9.770E-5 8.666E-4 3.615E-3 3 16
37 15386022 Role of histone H2A ubiquitination in Polycomb silencing. Pubmed 9.056E-7 9.770E-5 8.666E-4 3.615E-3 3 16
38 21903422 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Pubmed 1.146E-6 1.089E-4 9.663E-4 4.576E-3 6 283
39 19412891 Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
40 19835843 Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
41 22123502 Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
42 25843776 The Bmi-1 helix-turn and ring finger domains are required for Bmi-1 antagonism of (-) epigallocatechin-3-gallate suppression of skin cancer cell survival. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
43 18037880 Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
44 22562112 Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
45 22499591 Polycomb function during oogenesis is required for mouse embryonic development. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
46 26578590 RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
47 17157253 The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
48 11060235 Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
49 26788540 Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
50 19494812 Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Pubmed 1.419E-6 1.089E-4 9.663E-4 5.665E-3 2 2
Show 45 more annotations

9: Interaction [Display Chart] 46 input genes in category / 4026 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:UBE2D2 UBE2D2 interactions 1.958E-59 7.882E-56 6.997E-55 7.882E-56 37 280
2 int:UBE2D3 UBE2D3 interactions 1.692E-55 3.407E-52 3.024E-51 6.813E-52 34 229
3 int:UBE2D1 UBE2D1 interactions 2.293E-51 3.078E-48 2.732E-47 9.233E-48 33 257
4 int:UBE2E1 UBE2E1 interactions 9.846E-36 9.910E-33 8.798E-32 3.964E-32 22 129
5 int:UBE2D4 UBE2D4 interactions 3.688E-34 2.970E-31 2.637E-30 1.485E-30 20 97
6 int:UBE2U UBE2U interactions 9.963E-33 6.685E-30 5.935E-29 4.011E-29 18 69
7 int:UBE2K UBE2K interactions 4.569E-27 2.628E-24 2.333E-23 1.839E-23 17 104
8 int:UBE2E2 UBE2E2 interactions 6.503E-23 3.273E-20 2.905E-19 2.618E-19 14 78
9 int:UBE2N UBE2N interactions 1.360E-22 6.085E-20 5.402E-19 5.477E-19 18 232
10 int:UBE2E3 UBE2E3 interactions 6.626E-19 2.667E-16 2.368E-15 2.667E-15 13 108
11 int:UBE2W UBE2W interactions 4.143E-15 1.516E-12 1.346E-11 1.668E-11 10 76
12 int:UBE2L3 UBE2L3 interactions 1.403E-14 4.708E-12 4.180E-11 5.650E-11 12 172
13 int:UBE2H UBE2H interactions 1.032E-10 3.194E-8 2.836E-7 4.153E-7 8 94
14 int:UBE2I UBE2I interactions 1.479E-10 4.252E-8 3.775E-7 5.953E-7 13 476
15 int:USP2 USP2 interactions 3.682E-10 9.882E-8 8.773E-7 1.482E-6 8 110
16 int:OTUB2 OTUB2 interactions 9.213E-10 2.318E-7 2.058E-6 3.709E-6 6 41
17 int:USP7 USP7 interactions 1.109E-9 2.626E-7 2.331E-6 4.464E-6 11 350
18 int:TBK1 TBK1 interactions 3.533E-9 7.903E-7 7.016E-6 1.423E-5 8 146
19 int:JOSD1 JOSD1 interactions 5.979E-9 1.267E-6 1.125E-5 2.407E-5 5 26
20 int:TRIM8 TRIM8 interactions 7.208E-9 1.451E-6 1.288E-5 2.902E-5 6 57
21 int:UBE2J1 UBE2J1 interactions 5.821E-8 1.116E-5 9.908E-5 2.344E-4 5 40
22 int:PCBP2-OT1 PCBP2-OT1 interactions 6.556E-8 1.200E-5 1.065E-4 2.639E-4 3 4
23 int:UBE2V1 UBE2V1 interactions 1.160E-7 2.031E-5 1.803E-4 4.670E-4 6 90
24 int:AR AR interactions 1.426E-7 2.393E-5 2.124E-4 5.743E-4 9 329
25 int:TRIM27 TRIM27 interactions 1.621E-7 2.610E-5 2.318E-4 6.526E-4 9 334
26 int:ZFP42 ZFP42 interactions 1.875E-7 2.879E-5 2.556E-4 7.548E-4 4 20
27 int:UBE2L6 UBE2L6 interactions 1.931E-7 2.879E-5 2.556E-4 7.774E-4 6 98
28 int:TNFAIP3 TNFAIP3 interactions 2.598E-7 3.735E-5 3.316E-4 1.046E-3 6 103
29 int:YY2 YY2 interactions 3.266E-7 4.534E-5 4.025E-4 1.315E-3 3 6
30 int:TRAF2 TRAF2 interactions 3.429E-7 4.601E-5 4.085E-4 1.380E-3 9 365
31 int:IQCN IQCN interactions 5.054E-7 6.563E-5 5.827E-4 2.035E-3 5 61
32 int:MNAT1 MNAT1 interactions 6.963E-7 8.760E-5 7.777E-4 2.803E-3 5 65
33 int:UBE2C UBE2C interactions 7.519E-7 8.903E-5 7.904E-4 3.027E-3 5 66
34 int:TRAF5 TRAF5 interactions 7.519E-7 8.903E-5 7.904E-4 3.027E-3 5 66
35 int:NKD2 NKD2 interactions 7.803E-7 8.976E-5 7.969E-4 3.142E-3 4 28
36 int:YOD1 YOD1 interactions 1.040E-6 1.164E-4 1.033E-3 4.189E-3 4 30
37 int:AXIN1 AXIN1 interactions 1.124E-6 1.223E-4 1.086E-3 4.527E-3 6 132
38 int:ZNF785 ZNF785 interactions 1.247E-6 1.321E-4 1.173E-3 5.019E-3 5 73
39 int:ZIM2 ZIM2 interactions 1.364E-6 1.373E-4 1.219E-3 5.492E-3 3 9
40 int:MAGEE2 MAGEE2 interactions 1.364E-6 1.373E-4 1.219E-3 5.492E-3 3 9
41 int:EPN3 EPN3 interactions 1.545E-6 1.517E-4 1.347E-3 6.219E-3 4 33
42 int:ZNF740 ZNF740 interactions 1.945E-6 1.865E-4 1.655E-3 7.832E-3 3 10
43 int:TRAIP TRAIP interactions 2.474E-6 2.214E-4 1.965E-3 9.962E-3 4 37
44 int:HERPUD1 HERPUD1 interactions 2.474E-6 2.214E-4 1.965E-3 9.962E-3 4 37
45 int:DCUN1D5 DCUN1D5 interactions 2.474E-6 2.214E-4 1.965E-3 9.962E-3 4 37
46 int:TRIM28 TRIM28 interactions 2.739E-6 2.397E-4 2.128E-3 1.103E-2 8 347
47 int:DTX3L DTX3L interactions 3.070E-6 2.630E-4 2.335E-3 1.236E-2 4 39
48 int:IQSEC1 IQSEC1 interactions 3.405E-6 2.797E-4 2.483E-3 1.371E-2 4 40
49 int:UBE2T UBE2T interactions 3.405E-6 2.797E-4 2.483E-3 1.371E-2 4 40
50 int:PSMD3 PSMD3 interactions 3.573E-6 2.867E-4 2.546E-3 1.439E-2 6 161
Show 45 more annotations

10: Cytoband [Display Chart] 46 input genes in category / 44 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq22.3 Xq22.3 9.408E-4 1.945E-2
8.506E-2
 4.140E-2 2 34
2 Xq13-q21 Xq13-q21 1.327E-3 1.945E-2
8.506E-2
5.839E-2
 1 1
3 5q23.3-q31.1 5q23.3-q31.1 1.327E-3 1.945E-2
8.506E-2
5.839E-2
 1 1
4 16p11.2-p11.1 16p11.2-p11.1 2.653E-3 1.945E-2
8.506E-2
1.167E-1
 1 2
5 7q32-q34 7q32-q34 2.653E-3 1.945E-2
8.506E-2
1.167E-1
 1 2
6 1q25.1-q25.2 1q25.1-q25.2 2.653E-3 1.945E-2
8.506E-2
1.167E-1
 1 2
7 3q22-q24 3q22-q24 5.298E-3 3.330E-2
1.456E-1
2.331E-1
 1 4
8 1p34-p33 1p34-p33 6.618E-3 3.640E-2
1.592E-1
2.912E-1
 1 5
9 3q13.11 3q13.11 7.937E-3 3.880E-2
1.697E-1
3.492E-1
 1 6
10 6p22 6p22 1.057E-2 4.650E-2
2.033E-1
4.650E-1
 1 8
11 14q23 14q23 1.188E-2 4.753E-2
2.078E-1
5.228E-1
 1 9
12 11p12 11p12 1.450E-2 4.909E-2
2.147E-1
6.382E-1
 1 11
13 15q21 15q21 1.450E-2 4.909E-2
2.147E-1
6.382E-1
 1 11
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 32 input genes in category / 274 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 45 input genes in category / 16 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 58 Ring finger proteins|Tripartite motif containing genenames.org 1.640E-77 2.624E-76 8.872E-76 2.624E-76 43 275
2 59 Ring finger proteins|Tripartite motif containing genenames.org 6.720E-20 5.376E-19 1.817E-18 1.075E-18 13 96
3 88 Zinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases genenames.org 1.429E-3 7.623E-3 2.577E-2 2.287E-2 3 90
4 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 7.227E-3 2.891E-2
9.773E-2
1.156E-1
 3 160
5 1056 Ring finger proteins|WD repeat domain containing|TNF receptor associated factors genenames.org 1.719E-2 4.485E-2
1.516E-1
2.750E-1
 1 7
6 61 Ring finger proteins|Polycomb group ring fingers genenames.org 1.719E-2 4.485E-2
1.516E-1
2.750E-1
 1 7
7 419 Ring finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing genenames.org 1.962E-2 4.485E-2
1.516E-1
3.139E-1
 1 8
Show 2 more annotations

13: Coexpression [Display Chart] 46 input genes in category / 2822 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.378E-5 1.902E-2
1.621E-1
1.235E-1
 7 483
2 M9041 Genes up-regulated in macrophages with knockout of HDAC3 [GeneID=8841] after LPS treatment: heterozygous versus homozygous. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-5 1.902E-2
1.621E-1
1.331E-1
 5 200
3 M7868 Genes down-regulated in CD4 [GeneID=920] T cells: untreated versus IL6 and TGFB1 [GeneID=3569;7040]. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-5 1.902E-2
1.621E-1
1.331E-1
 5 200
4 M8698 Genes up-regulated in bone marrow-derived macrophages: heterozygous versus homozygous knockout of MLL4 [GeneID=9757]. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-5 1.902E-2
1.621E-1
1.331E-1
 5 200
5 M3882 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-5 1.902E-2
1.621E-1
1.331E-1
 5 200
6 M9321 Genes down-regulated in marginal zone B cells versus day 7 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-5 1.902E-2
1.621E-1
1.331E-1
 5 200
7 M6360 Genes down-regulated in gamma delta T cells stimulated by phorbol myristate acetate and ionomycin [PubChem=4792;3733]: Vd1 versus Vd2. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-5 1.902E-2
1.621E-1
1.331E-1
 5 200
8 19336457-Table2 Human Brain Tchoghandjian09 153genes GeneSigDB 1.218E-4 4.297E-2
3.662E-1
3.438E-1
 4 128
Show 3 more annotations

14: Coexpression Atlas [Display Chart] 46 input genes in category / 1437 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 32 input genes in category / 205 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 46 input genes in category / 1466 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 1.415E-9 2.075E-6 1.633E-5 2.075E-6 7 319
2 hsa-miR-194:PITA hsa-miR-194:PITA TOP PITA 8.654E-7 6.343E-4 4.991E-3 1.269E-3 5 271
3 hsa-miR-942-5p:Non-Functional MTI Non-Functional MTI miRTarbase 8.661E-6 3.648E-3 2.870E-2 1.270E-2 4 201
4 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 1.431E-5 3.648E-3 2.870E-2 2.098E-2 5 483
5 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 1.431E-5 3.648E-3 2.870E-2 2.098E-2 5 483
6 hsa-miR-5702:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.580E-5 3.648E-3 2.870E-2 2.316E-2 3 75
7 hsa-miR-551a:mirSVR highEffct hsa-miR-551a:mirSVR conserved highEffect-0.5 MicroRNA.org 1.918E-5 3.648E-3 2.870E-2 2.812E-2 3 80
8 hsa-miR-633:Functional MTI Functional MTI miRTarbase 1.991E-5 3.648E-3 2.870E-2 2.918E-2 3 81
9 hsa-miR-586:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.012E-5 4.906E-3 3.860E-2 4.415E-2 3 93
10 ATAGGAA,MIR-202:MSigDB ATAGGAA,MIR-202:MSigDB MSigDB 3.631E-5 5.322E-3 4.188E-2
5.322E-2
 3 99
11 hsa-miR-203a-3p:Functional MTI Functional MTI miRTarbase 4.591E-5 5.756E-3 4.528E-2
6.731E-2
 4 308
12 hsa-miR-4537:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.887E-5 5.756E-3 4.528E-2
7.164E-2
 4 313
13 hsa-miR-300:Functional MTI Functional MTI miRTarbase 6.126E-5 5.756E-3 4.528E-2
8.981E-2
 3 118
14 hsa-miR-4492:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.282E-5 5.756E-3 4.528E-2
9.209E-2
 3 119
15 hsa-miR-4498:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.282E-5 5.756E-3 4.528E-2
9.209E-2
 3 119
16 hsa-miR-5001-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.282E-5 5.756E-3 4.528E-2
9.209E-2
 3 119
17 hsa-miR-762:Functional MTI Functional MTI miRTarbase 6.930E-5 5.976E-3 4.702E-2
1.016E-1
 3 123
18 hsa-miR-183-5p:Functional MTI Functional MTI miRTarbase 7.609E-5 6.087E-3 4.789E-2
1.116E-1
 4 351
19 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 7.949E-5 6.087E-3 4.789E-2
1.165E-1
 4 355
20 hsa-miR-496.2:TargetScan hsa-miR-496.2 TargetScan 8.546E-5 6.087E-3 4.789E-2
1.253E-1
 3 132
21 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 8.753E-5 6.087E-3 4.789E-2
1.283E-1
 4 364
22 hsa-miR-597:PITA hsa-miR-597:PITA TOP PITA 9.134E-5 6.087E-3 4.789E-2
1.339E-1
 3 135
23 hsa-miR-431*:mirSVR lowEffct hsa-miR-431*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.615E-5 6.129E-3 4.822E-2
1.410E-1
 4 373
24 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 1.075E-4 6.567E-3
5.167E-2
1.576E-1
 4 384
25 hsa-miR-629:PITA hsa-miR-629:PITA TOP PITA 1.323E-4 7.755E-3
6.102E-2
1.939E-1
 3 153
26 hsa-miR-325:mirSVR highEffct hsa-miR-325:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.474E-4 8.312E-3
6.540E-2
2.161E-1
 4 417
27 hsa-miR-646:PITA hsa-miR-646:PITA TOP PITA 1.763E-4 8.643E-3
6.800E-2
2.584E-1
 4 437
28 hsa-miR-146b-5p:PITA hsa-miR-146b-5p:PITA TOP PITA 1.835E-4 8.643E-3
6.800E-2
2.691E-1
 3 171
29 hsa-miR-146a:PITA hsa-miR-146a:PITA TOP PITA 1.835E-4 8.643E-3
6.800E-2
2.691E-1
 3 171
30 hsa-miR-491-5p:Functional MTI Functional MTI miRTarbase 1.867E-4 8.643E-3
6.800E-2
2.737E-1
 3 172
31 hsa-miR-17-3p:Functional MTI Functional MTI miRTarbase 1.899E-4 8.643E-3
6.800E-2
2.784E-1
 3 173
32 hsa-miR-548as-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.899E-4 8.643E-3
6.800E-2
2.784E-1
 3 173
33 hsa-miR-501-3p:mirSVR highEffct hsa-miR-501-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.971E-4 8.643E-3
6.800E-2
2.889E-1
 4 450
34 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 2.004E-4 8.643E-3
6.800E-2
2.939E-1
 4 452
35 hsa-miR-1911*:mirSVR highEffct hsa-miR-1911*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.108E-4 8.828E-3
6.945E-2
3.090E-1
 4 458
36 hsa-miR-495-3p:Functional MTI Functional MTI miRTarbase 2.276E-4 9.221E-3
7.255E-2
3.337E-1
 3 184
37 hsa-miR-6783-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.350E-4 9.221E-3
7.255E-2
3.445E-1
 3 186
38 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 2.499E-4 9.221E-3
7.255E-2
3.663E-1
 4 479
39 hsa-miR-187:mirSVR highEffct hsa-miR-187:mirSVR conserved highEffect-0.5 MicroRNA.org 2.501E-4 9.221E-3
7.255E-2
3.666E-1
 3 190
40 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 2.579E-4 9.221E-3
7.255E-2
3.780E-1
 4 483
41 CTTGTAT,MIR-381:MSigDB CTTGTAT,MIR-381:MSigDB MSigDB 2.579E-4 9.221E-3
7.255E-2
3.781E-1
 3 192
42 hsa-miR-1253:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.699E-4 9.265E-3
7.289E-2
3.956E-1
 3 195
43 hsa-miR-154:PITA hsa-miR-154:PITA TOP PITA 2.739E-4 9.265E-3
7.289E-2
4.016E-1
 3 196
44 hsa-miR-376c-3p:TargetScan hsa-miR-376c-3p TargetScan 2.781E-4 9.265E-3
7.289E-2
4.076E-1
 3 197
45 hsa-miR-425-5p:TargetScan hsa-miR-425-5p TargetScan 2.992E-4 9.744E-3
7.667E-2
4.387E-1
 3 202
46 AAGCAAT,MIR-137:MSigDB AAGCAAT,MIR-137:MSigDB MSigDB 3.124E-4 9.744E-3
7.667E-2
4.580E-1
 3 205
47 hsa-miR-202-5p:TargetScan hsa-miR-202-5p TargetScan 3.124E-4 9.744E-3
7.667E-2
4.580E-1
 3 205
48 hsa-miR-329:PITA hsa-miR-329:PITA TOP PITA 3.590E-4 1.067E-2
8.395E-2
5.263E-1
 3 215
49 hsa-miR-362-3p:PITA hsa-miR-362-3p:PITA TOP PITA 3.590E-4 1.067E-2
8.395E-2
5.263E-1
 3 215
50 CTGAGCC,MIR-24:MSigDB CTGAGCC,MIR-24:MSigDB MSigDB 3.639E-4 1.067E-2
8.395E-2
5.335E-1
 3 216
Show 45 more annotations

17: Drug [Display Chart] 46 input genes in category / 6950 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000005569 trifluralin Stitch 7.717E-9 5.363E-5 5.054E-4 5.363E-5 7 131
2 CID000001826 5-HIAA Stitch 2.247E-7 7.808E-4 7.358E-3 1.562E-3 6 129
3 CID006432095 Ph(2 Stitch 7.372E-6 1.708E-2
1.609E-1
5.124E-2
 4 62
4 CID000010010 homocystine Stitch 2.245E-5 3.900E-2
3.675E-1
1.560E-1
 4 82

18: Disease [Display Chart] 44 input genes in category / 557 annotations before applied cutoff / 16205 genes in category

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