Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc97_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 47 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031755 Edg-2 lysophosphatidic acid receptor binding 1.071E-3 1.446E-2
6.416E-2
5.036E-2
 1 2
2 GO:0031753 endothelial differentiation G protein-coupled receptor binding 1.071E-3 1.446E-2
6.416E-2
5.036E-2
 1 2
3 GO:0003779 actin binding 1.142E-3 1.446E-2
6.416E-2
5.368E-2
 3 412
4 GO:0034988 Fc-gamma receptor I complex binding 1.607E-3 1.446E-2
6.416E-2
7.552E-2
 1 3
5 GO:0019808 polyamine binding 1.607E-3 1.446E-2
6.416E-2
7.552E-2
 1 3
6 GO:0031852 mu-type opioid receptor binding 2.142E-3 1.446E-2
6.416E-2
1.007E-1
 1 4
7 GO:0051015 actin filament binding 2.153E-3 1.446E-2
6.416E-2
1.012E-1
 2 132
8 GO:0031628 opioid receptor binding 4.814E-3 2.828E-2
1.255E-1
2.262E-1
 1 9
9 GO:0017160 Ral GTPase binding 6.946E-3 3.627E-2
1.610E-1
3.265E-1
 1 13
10 GO:0031005 filamin binding 8.543E-3 3.875E-2
1.720E-1
4.015E-1
 1 16
11 GO:0001664 G protein-coupled receptor binding 9.069E-3 3.875E-2
1.720E-1
4.263E-1
 2 276
12 GO:0030506 ankyrin binding 1.120E-2 4.386E-2
1.947E-1
5.264E-1
 1 21
Show 7 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 257 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034329 cell junction assembly 1.385E-4 3.560E-2
2.181E-1
 3.560E-2 3 200
2 GO:0034330 cell junction organization 2.935E-4 3.771E-2
2.311E-1
7.542E-2
 3 258
3 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 6.866E-4 4.598E-2
2.818E-1
1.765E-1
 2 74
4 GO:0031532 actin cytoskeleton reorganization 1.013E-3 4.598E-2
2.818E-1
2.605E-1
 2 90
5 GO:0032507 maintenance of protein location in cell 1.128E-3 4.598E-2
2.818E-1
2.900E-1
 2 95
6 GO:0045185 maintenance of protein location 1.402E-3 4.598E-2
2.818E-1
3.603E-1
 2 106
7 GO:0051651 maintenance of location in cell 1.455E-3 4.598E-2
2.818E-1
3.738E-1
 2 108
8 GO:0055011 atrial cardiac muscle cell differentiation 1.610E-3 4.598E-2
2.818E-1
4.138E-1
 1 3
9 GO:0055014 atrial cardiac muscle cell development 1.610E-3 4.598E-2
2.818E-1
4.138E-1
 1 3
Show 4 more annotations

3: GO: Cellular Component [Display Chart] 10 input genes in category / 56 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005912 adherens junction 7.325E-10 4.102E-8 1.892E-7 4.102E-8 7 484
2 GO:0005925 focal adhesion 1.448E-8 2.356E-7 1.086E-6 8.111E-7 6 393
3 GO:0005924 cell-substrate adherens junction 1.562E-8 2.356E-7 1.086E-6 8.747E-7 6 398
4 GO:0030055 cell-substrate junction 1.683E-8 2.356E-7 1.086E-6 9.423E-7 6 403
5 GO:0015629 actin cytoskeleton 2.161E-6 2.420E-5 1.116E-4 1.210E-4 5 476
6 GO:0032432 actin filament bundle 6.344E-6 5.921E-5 2.730E-4 3.552E-4 3 73
7 GO:0030018 Z disc 2.758E-5 2.206E-4 1.017E-3 1.544E-3 3 119
8 GO:0031674 I band 4.021E-5 2.814E-4 1.298E-3 2.252E-3 3 135
9 GO:0030017 sarcomere 1.255E-4 7.812E-4 3.602E-3 7.031E-3 3 198
10 GO:0044449 contractile fiber part 1.602E-4 8.728E-4 4.025E-3 8.970E-3 3 215
11 GO:0030016 myofibril 1.714E-4 8.728E-4 4.025E-3 9.600E-3 3 220
12 GO:0043292 contractile fiber 2.057E-4 9.598E-4 4.426E-3 1.152E-2 3 234
13 GO:0005938 cell cortex 2.999E-4 1.292E-3 5.957E-3 1.679E-2 3 266
14 GO:0001725 stress fiber 5.378E-4 1.887E-3 8.703E-3 3.012E-2 2 67
15 GO:0097517 contractile actin filament bundle 5.378E-4 1.887E-3 8.703E-3 3.012E-2 2 67
16 GO:0099568 cytoplasmic region 5.392E-4 1.887E-3 8.703E-3 3.020E-2 3 325
17 GO:0042641 actomyosin 7.098E-4 2.338E-3 1.078E-2 3.975E-2 2 77
18 GO:0031523 Myb complex 1.573E-3 4.894E-3 2.257E-2
8.810E-2
 1 3
19 GO:0005903 brush border 1.974E-3 5.818E-3 2.683E-2
1.105E-1
 2 129
20 GO:0098862 cluster of actin-based cell projections 3.593E-3 1.006E-2 4.640E-2
2.012E-1
 2 175
21 GO:0097440 apical dendrite 9.406E-3 2.508E-2
1.157E-1
5.267E-1
 1 18
22 GO:0043034 costamere 1.097E-2 2.791E-2
1.287E-1
6.141E-1
 1 21
23 GO:0031430 M band 1.200E-2 2.923E-2
1.348E-1
6.722E-1
 1 23
24 GO:0031941 filamentous actin 1.408E-2 3.255E-2
1.501E-1
7.884E-1
 1 27
25 GO:0035869 ciliary transition zone 1.511E-2 3.255E-2
1.501E-1
8.464E-1
 1 29
26 GO:0097546 ciliary base 1.511E-2 3.255E-2
1.501E-1
8.464E-1
 1 29
27 GO:0005911 cell-cell junction 1.922E-2 3.985E-2
1.838E-1
1.000E0
 2 418
28 GO:0032391 photoreceptor connecting cilium 2.079E-2 4.159E-2
1.918E-1
1.000E0
 1 40
29 GO:0031672 A band 2.234E-2 4.313E-2
1.989E-1
1.000E0
 1 43
30 GO:0032154 cleavage furrow 2.542E-2 4.592E-2
2.117E-1
1.000E0
 1 49
31 GO:0097610 cell surface furrow 2.542E-2 4.592E-2
2.117E-1
1.000E0
 1 49
Show 26 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 1126 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004232 Accessory carpal bones 1.896E-6 1.067E-3 8.117E-3 2.135E-3 2 2
2 HP:0008127 Bipartite calcaneus 1.896E-6 1.067E-3 8.117E-3 2.135E-3 2 2
3 HP:0003304 Spondylolysis 1.892E-5 7.101E-3
5.400E-2
 2.130E-2 2 5
4 HP:0009651 Broad phalanges of the thumb 3.968E-5 1.117E-2
8.493E-2
 4.468E-2 2 7
5 HP:0002990 Fibular aplasia 1.243E-4 2.537E-2
1.929E-1
1.399E-1
 2 12
6 HP:0009836 Broad distal phalanx of finger 1.711E-4 2.537E-2
1.929E-1
1.926E-1
 2 14
7 HP:0000774 Narrow chest 2.165E-4 2.537E-2
1.929E-1
2.438E-1
 3 89
8 HP:0002986 Radial bowing 2.253E-4 2.537E-2
1.929E-1
2.537E-1
 2 16
9 HP:0045008 Abnormal shape of the radius 2.253E-4 2.537E-2
1.929E-1
2.537E-1
 2 16
10 HP:0002949 Fused cervical vertebrae 2.253E-4 2.537E-2
1.929E-1
2.537E-1
 2 16
11 HP:0011815 Cephalocele 2.972E-4 2.788E-2
2.120E-1
3.346E-1
 3 99
12 HP:0002084 Encephalocele 2.972E-4 2.788E-2
2.120E-1
3.346E-1
 3 99
13 HP:0000283 Broad face 3.557E-4 2.801E-2
2.130E-1
4.005E-1
 2 20
14 HP:0003956 Bowed forearm bones 3.928E-4 2.801E-2
2.130E-1
4.423E-1
 2 21
15 HP:0005257 Thoracic hypoplasia 4.060E-4 2.801E-2
2.130E-1
4.571E-1
 3 110
16 HP:0008515 Aplasia/Hypoplasia of the vertebrae 4.726E-4 2.801E-2
2.130E-1
5.322E-1
 2 23
17 HP:0006488 Bowing of the arm 4.726E-4 2.801E-2
2.130E-1
5.322E-1
 2 23
18 HP:0008417 Vertebral hypoplasia 4.726E-4 2.801E-2
2.130E-1
5.322E-1
 2 23
19 HP:0009617 Abnormality of the distal phalanx of the thumb 4.726E-4 2.801E-2
2.130E-1
5.322E-1
 2 23
20 HP:0006493 Aplasia/hypoplasia involving bones of the lower limbs 5.374E-4 2.864E-2
2.178E-1
6.052E-1
 4 308
21 HP:0008368 Tarsal synostosis 5.596E-4 2.864E-2
2.178E-1
6.301E-1
 2 25
22 HP:0005792 Short humerus 5.596E-4 2.864E-2
2.178E-1
6.301E-1
 2 25
23 HP:0006507 Aplasia/hypoplasia of the humerus 6.538E-4 3.201E-2
2.434E-1
7.362E-1
 2 27
24 HP:0008364 Abnormality of the calcaneus 7.552E-4 3.339E-2
2.539E-1
8.504E-1
 2 29
25 HP:0009140 Synostosis involving bones of the feet 8.086E-4 3.339E-2
2.539E-1
9.104E-1
 2 30
26 HP:0009138 Synostosis involving bones of the lower limbs 8.086E-4 3.339E-2
2.539E-1
9.104E-1
 2 30
27 HP:0011877 Increased mean platelet volume 8.086E-4 3.339E-2
2.539E-1
9.104E-1
 2 30
28 HP:0003310 Abnormality of the odontoid process 8.637E-4 3.339E-2
2.539E-1
9.725E-1
 2 31
29 HP:0002777 Tracheal stenosis 8.637E-4 3.339E-2
2.539E-1
9.725E-1
 2 31
30 HP:0011876 Abnormal platelet volume 9.793E-4 3.339E-2
2.539E-1
1.000E0
 2 33
31 HP:0003826 Stillbirth 9.793E-4 3.339E-2
2.539E-1
1.000E0
 2 33
32 HP:0009702 Carpal synostosis 9.793E-4 3.339E-2
2.539E-1
1.000E0
 2 33
33 HP:0002982 Tibial bowing 1.369E-3 3.339E-2
2.539E-1
1.000E0
 2 39
34 HP:0009603 Deviation of the thumb 1.440E-3 3.339E-2
2.539E-1
1.000E0
 2 40
35 HP:0011580 Short chordae tendineae of the mitral valve 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
36 HP:0011245 Abnormality of superior crus of antihelix 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
37 HP:0005446 Obtuse angle of mandible 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
38 HP:0006692 Short chordae tendineae of the tricuspid valve 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
39 HP:0008087 Nonossified fifth metatarsal 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
40 HP:0006408 Distal tapering femur 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
41 HP:0031442 Abnormal tricuspid chordae tendinae morphology 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
42 HP:0004592 Thoracic platyspondyly 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
43 HP:0003994 Dislocated wrist 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
44 HP:0001782 Bulbous tips of toes 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
45 HP:0004632 Cervical segmentation defect 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
46 HP:0011246 Underdeveloped superior crus of antihelix 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
47 HP:0005090 Lateral femoral bowing 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
48 HP:0030330 Multinucleated giant chondrocytes in epiphyseal cartilage 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
49 HP:0010560 Undulate clavicles 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
50 HP:0006060 Tombstone-shaped proximal phalanges 1.487E-3 3.339E-2
2.539E-1
1.000E0
 1 1
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 461 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 10 input genes in category / 67 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00557 IG FLMN SMART 1.312E-8 2.416E-7 1.157E-6 8.787E-7 3 10
2 IPR001298 Filamin/ABP280 rpt InterPro 1.803E-8 2.416E-7 1.157E-6 1.208E-6 3 11
3 IPR017868 Filamin/ABP280 repeat-like InterPro 1.803E-8 2.416E-7 1.157E-6 1.208E-6 3 11
4 PF00630 Filamin Pfam 1.803E-8 2.416E-7 1.157E-6 1.208E-6 3 11
5 PS50194 FILAMIN REPEAT PROSITE 1.803E-8 2.416E-7 1.157E-6 1.208E-6 3 11
6 PS00020 ACTININ 2 PROSITE 1.929E-7 1.615E-6 7.735E-6 1.292E-5 3 23
7 PS00019 ACTININ 1 PROSITE 1.929E-7 1.615E-6 7.735E-6 1.292E-5 3 23
8 IPR001589 Actinin actin-bd CS InterPro 1.929E-7 1.615E-6 7.735E-6 1.292E-5 3 23
9 SM00033 CH SMART 4.701E-6 3.499E-5 1.676E-4 3.150E-4 3 65
10 PF00307 CH Pfam 5.883E-6 3.729E-5 1.786E-4 3.941E-4 3 70
11 1.10.418.10 - Gene3D 6.141E-6 3.729E-5 1.786E-4 4.114E-4 3 71
12 PS50021 CH PROSITE 6.678E-6 3.729E-5 1.786E-4 4.475E-4 3 73
13 IPR001715 CH-domain InterPro 7.247E-6 3.735E-5 1.789E-4 4.855E-4 3 75
14 IPR014756 Ig E-set InterPro 1.938E-5 9.277E-5 4.443E-4 1.299E-3 3 104
15 IPR029874 FLNB InterPro 5.338E-4 1.675E-3 8.020E-3 3.576E-2 1 1
16 IPR032461 FLN C InterPro 5.338E-4 1.675E-3 8.020E-3 3.576E-2 1 1
17 IPR030642 NPHP1 InterPro 5.338E-4 1.675E-3 8.020E-3 3.576E-2 1 1
18 IPR030522 SH2B3 InterPro 5.338E-4 1.675E-3 8.020E-3 3.576E-2 1 1
19 IPR028559 FLN A InterPro 5.338E-4 1.675E-3 8.020E-3 3.576E-2 1 1
20 PF00412 LIM Pfam 5.902E-4 1.675E-3 8.020E-3 3.954E-2 2 69
21 2.10.110.10 - Gene3D 6.074E-4 1.675E-3 8.020E-3 4.069E-2 2 70
22 PS50023 LIM DOMAIN 2 PROSITE 6.248E-4 1.675E-3 8.020E-3 4.186E-2 2 71
23 PS00478 LIM DOMAIN 1 PROSITE 6.248E-4 1.675E-3 8.020E-3 4.186E-2 2 71
24 IPR001781 Znf LIM InterPro 6.248E-4 1.675E-3 8.020E-3 4.186E-2 2 71
25 SM00132 LIM SMART 6.248E-4 1.675E-3 8.020E-3 4.186E-2 2 71
26 IPR028412 Ral InterPro 1.067E-3 2.750E-3 1.317E-2
7.151E-2
 1 2
27 PF08916 Phe ZIP Pfam 1.601E-3 3.698E-3 1.771E-2
1.072E-1
 1 3
28 IPR030523 SH2B InterPro 1.601E-3 3.698E-3 1.771E-2
1.072E-1
 1 3
29 IPR015012 Phe ZIP InterPro 1.601E-3 3.698E-3 1.771E-2
1.072E-1
 1 3
30 PF09727 CortBP2 Pfam 2.134E-3 4.611E-3 2.208E-2
1.429E-1
 1 4
31 IPR019131 Cortactin-binding p2 N InterPro 2.134E-3 4.611E-3 2.208E-2
1.429E-1
 1 4
32 IPR000308 14-3-3 InterPro 4.263E-3 8.925E-3 4.275E-2
2.856E-1
 1 8
33 PF07562 NCD3G Pfam 6.919E-3 1.363E-2
6.530E-2
4.636E-1
 1 13
34 IPR011500 GPCR 3 9-Cys dom InterPro 6.919E-3 1.363E-2
6.530E-2
4.636E-1
 1 13
35 IPR017979 GPCR 3 CS InterPro 7.449E-3 1.426E-2
6.830E-2
4.991E-1
 1 14
36 IPR000337 GPCR 3 InterPro 1.116E-2 1.864E-2
8.927E-2
7.474E-1
 1 21
37 PS50259 G PROTEIN RECEP F3 4 PROSITE 1.168E-2 1.864E-2
8.927E-2
7.828E-1
 1 22
38 PS00981 G PROTEIN RECEP F3 3 PROSITE 1.168E-2 1.864E-2
8.927E-2
7.828E-1
 1 22
39 PF00003 7tm 3 Pfam 1.168E-2 1.864E-2
8.927E-2
7.828E-1
 1 22
40 PS00980 G PROTEIN RECEP F3 2 PROSITE 1.168E-2 1.864E-2
8.927E-2
7.828E-1
 1 22
41 IPR017978 GPCR 3 C InterPro 1.168E-2 1.864E-2
8.927E-2
7.828E-1
 1 22
42 PS00979 G PROTEIN RECEP F3 1 PROSITE 1.168E-2 1.864E-2
8.927E-2
7.828E-1
 1 22
43 PS51421 RAS PROSITE 1.853E-2 2.852E-2
1.366E-1
1.000E0
 1 35
44 IPR001828 ANF lig-bd rcpt InterPro 1.958E-2 2.852E-2
1.366E-1
1.000E0
 1 37
45 PF01094 ANF receptor Pfam 1.958E-2 2.852E-2
1.366E-1
1.000E0
 1 37
46 IPR020849 Small GTPase Ras InterPro 1.958E-2 2.852E-2
1.366E-1
1.000E0
 1 37
47 IPR028082 Peripla BP I InterPro 2.063E-2 2.941E-2
1.408E-1
1.000E0
 1 39
Show 42 more annotations

7: Pathway [Display Chart] 9 input genes in category / 62 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270237 Cell-extracellular matrix interactions BioSystems: REACTOME 1.456E-7 9.027E-6 4.254E-5 9.027E-6 3 16
2 375172 Salmonella infection BioSystems: KEGG 2.594E-5 5.943E-4 2.801E-3 1.608E-3 3 86
3 1270232 Cell junction organization BioSystems: REACTOME 2.876E-5 5.943E-4 2.801E-3 1.783E-3 3 89
4 1270231 Cell-Cell communication BioSystems: REACTOME 9.767E-5 1.514E-3 7.134E-3 6.056E-3 3 134
5 M16801 Genes related to regulation of the actin cytoskeleton MSigDB C2 BIOCARTA (v6.0) 2.730E-4 2.956E-3 1.393E-2 1.693E-2 2 35
6 83067 Focal adhesion BioSystems: KEGG 3.147E-4 2.956E-3 1.393E-2 1.951E-2 3 199
7 782000 Proteoglycans in cancer BioSystems: KEGG 3.337E-4 2.956E-3 1.393E-2 2.069E-2 3 203
8 83048 MAPK signaling pathway BioSystems: KEGG 6.510E-4 5.045E-3 2.378E-2 4.036E-2 3 255
9 P00034 Integrin signalling pathway PantherDB 6.052E-3 4.169E-2
1.965E-1
3.752E-1
 2 167
10 1269351 GP1b-IX-V activation signalling BioSystems: REACTOME 7.208E-3 4.469E-2
2.106E-1
4.469E-1
 1 10
Show 5 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 1704 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12006559 Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. Pubmed 1.184E-14 2.018E-11 1.618E-10 2.018E-11 4 5
2 12393796 Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Pubmed 1.292E-11 5.506E-9 4.415E-8 2.202E-8 3 3
3 11252955 Filamins as integrators of cell mechanics and signalling. Pubmed 1.292E-11 5.506E-9 4.415E-8 2.202E-8 3 3
4 11153914 Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family. Pubmed 1.292E-11 5.506E-9 4.415E-8 2.202E-8 3 3
5 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Pubmed 3.355E-11 1.143E-8 9.167E-8 5.716E-8 6 285
6 22802962 Structural interaction and functional regulation of polycystin-2 by filamin. Pubmed 5.169E-11 1.258E-8 1.009E-7 8.808E-8 3 4
7 11739414 The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. Pubmed 5.169E-11 1.258E-8 1.009E-7 8.808E-8 3 4
8 17360453 Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Pubmed 1.292E-10 2.446E-8 1.962E-7 2.202E-7 3 5
9 19366992 HIV infection of T cells: actin-in and actin-out. Pubmed 1.292E-10 2.446E-8 1.962E-7 2.202E-7 3 5
10 18157088 Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. Pubmed 2.388E-10 4.003E-8 3.209E-7 4.069E-7 4 41
11 12679033 Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Pubmed 2.584E-10 4.003E-8 3.209E-7 4.403E-7 3 6
12 16076904 The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins. Pubmed 4.521E-10 5.926E-8 4.752E-7 7.704E-7 3 7
13 17145501 MEKK4 signaling regulates filamin expression and neuronal migration. Pubmed 4.521E-10 5.926E-8 4.752E-7 7.704E-7 3 7
14 11807098 Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. Pubmed 1.085E-9 1.320E-7 1.059E-6 1.848E-6 3 9
15 12119179 Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. Pubmed 1.052E-8 1.196E-6 9.587E-6 1.793E-5 3 18
16 18487259 Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method. Pubmed 1.985E-8 2.114E-6 1.695E-5 3.383E-5 3 22
17 15509752 Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
18 17635842 Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
19 7689010 Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
20 11163396 Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
21 15657061 High affinity interaction with filamin A protects against calcium-sensing receptor degradation. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
22 24469451 A novel structural unit in the N-terminal region of filamins. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
23 11390379 Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
24 27206800 Signaling regulation and role of filamin A cleavage in Ca2+-stimulated migration of androgen receptor-deficient prostate cancer cells. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
25 21325628 Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
26 9694715 A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
27 12525170 The limits of promiscuity: isoform-specific dimerization of filamins. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
28 27872158 Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
29 10679933 Filamin isogene expression during mouse myogenesis. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
30 11336782 Structural and functional aspects of filamins. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
31 12496242 A new member of the LIM protein family binds to filamin B and localizes at stress fibers. Pubmed 6.170E-8 3.392E-6 2.719E-5 1.051E-4 2 2
32 11102480 Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
33 11390380 Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
34 9412467 Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
35 15837785 Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
36 11038172 Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
37 16291724 CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
38 18829455 Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
39 12704190 The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
40 21524097 Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
41 22174152 GPIbα regulates platelet size by controlling the subcellular localization of filamin. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
42 28175289 Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
43 12055638 Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone. Pubmed 1.851E-7 7.334E-6 5.881E-5 3.154E-4 2 3
44 28378594 Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations. Pubmed 2.899E-7 1.123E-5 9.001E-5 4.940E-4 4 236
45 17360532 Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. Pubmed 3.701E-7 1.314E-5 1.053E-4 6.306E-4 2 4
46 20554076 The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin. Pubmed 3.701E-7 1.314E-5 1.053E-4 6.306E-4 2 4
47 16355270 Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation. Pubmed 3.701E-7 1.314E-5 1.053E-4 6.306E-4 2 4
48 9437013 Interaction of presenilins with the filamin family of actin-binding proteins. Pubmed 3.701E-7 1.314E-5 1.053E-4 6.306E-4 2 4
49 10051605 The small GTPase RalA targets filamin to induce filopodia. Pubmed 6.167E-7 2.061E-5 1.652E-4 1.051E-3 2 5
50 8088838 Comparative mapping of the actin-binding protein 280 genes in human and mouse. Pubmed 6.167E-7 2.061E-5 1.652E-4 1.051E-3 2 5
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 712 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FLNA FLNA interactions 5.560E-13 3.959E-10 2.829E-9 3.959E-10 8 328
2 int:FLNB FLNB interactions 1.428E-11 5.083E-9 3.633E-8 1.017E-8 6 116
3 int:ITGB6 ITGB6 interactions 1.088E-8 2.583E-6 1.846E-5 7.749E-6 3 9
4 int:OTUD1 OTUD1 interactions 2.137E-8 3.803E-6 2.718E-5 1.521E-5 3 11
5 int:FBLIM1 FBLIM1 interactions 2.848E-8 4.055E-6 2.898E-5 2.028E-5 3 12
6 int:HSPB7 HSPB7 interactions 5.885E-8 6.983E-6 4.990E-5 4.190E-5 3 15
7 int:TRIM55 TRIM55 interactions 1.463E-7 1.488E-5 1.063E-4 1.042E-4 4 93
8 int:NPHP1 NPHP1 interactions 4.661E-7 4.148E-5 2.964E-4 3.319E-4 4 124
9 int:CARD8 CARD8 interactions 2.827E-6 1.702E-4 1.217E-3 2.013E-3 3 52
10 int:RAB8B RAB8B interactions 2.827E-6 1.702E-4 1.217E-3 2.013E-3 3 52
11 int:MAP2K4 MAP2K4 interactions 2.827E-6 1.702E-4 1.217E-3 2.013E-3 3 52
12 int:FILIP1 FILIP1 interactions 2.869E-6 1.702E-4 1.217E-3 2.043E-3 2 5
13 int:NPHP4 NPHP4 interactions 5.389E-6 2.951E-4 2.109E-3 3.837E-3 4 229
14 int:RALA RALA interactions 7.907E-6 3.976E-4 2.841E-3 5.630E-3 3 73
15 int:MCM5 MCM5 interactions 8.377E-6 3.976E-4 2.841E-3 5.965E-3 4 256
16 int:PSEN2 PSEN2 interactions 9.288E-6 4.133E-4 2.954E-3 6.613E-3 3 77
17 int:TES TES interactions 1.334E-5 5.586E-4 3.991E-3 9.496E-3 4 288
18 int:IQCB1 IQCB1 interactions 1.970E-5 7.792E-4 5.568E-3 1.403E-2 4 318
19 int:SH2B3 SH2B3 interactions 2.233E-5 8.367E-4 5.979E-3 1.590E-2 2 13
20 int:CASR CASR interactions 3.004E-5 9.709E-4 6.938E-3 2.139E-2 2 15
21 int:MYOT MYOT interactions 3.004E-5 9.709E-4 6.938E-3 2.139E-2 2 15
22 int:FLNC FLNC interactions 3.100E-5 9.709E-4 6.938E-3 2.207E-2 3 115
23 int:MYH9 MYH9 interactions 3.136E-5 9.709E-4 6.938E-3 2.233E-2 4 358
24 int:GP1BA GP1BA interactions 3.888E-5 1.154E-3 8.243E-3 2.768E-2 2 17
25 int:MYOZ1 MYOZ1 interactions 4.373E-5 1.245E-3 8.900E-3 3.114E-2 2 18
26 int:ITGB1 ITGB1 interactions 4.787E-5 1.311E-3 9.367E-3 3.408E-2 3 133
27 int:SYNPO2 SYNPO2 interactions 5.427E-5 1.431E-3 1.023E-2 3.864E-2 2 20
28 int:KCND2 KCND2 interactions 7.220E-5 1.836E-3 1.312E-2
5.141E-2
 2 23
29 int:GNG12 GNG12 interactions 1.239E-4 3.041E-3 2.173E-2
8.820E-2
 2 30
30 int:DYNC1H1 DYNC1H1 interactions 1.297E-4 3.079E-3 2.200E-2
9.236E-2
 3 186
31 int:CAMKK2 CAMKK2 interactions 1.502E-4 3.450E-3 2.466E-2
1.070E-1
 2 33
32 int:FURIN FURIN interactions 1.893E-4 4.211E-3 3.009E-2
1.348E-1
 2 37
33 int:ASB2 ASB2 interactions 1.997E-4 4.309E-3 3.079E-2
1.422E-1
 2 38
34 int:RASSF5 RASSF5 interactions 2.807E-4 5.646E-3 4.034E-2
1.998E-1
 2 45
35 int:DCTN3 DCTN3 interactions 2.807E-4 5.646E-3 4.034E-2
1.998E-1
 2 45
36 int:ABCE1 ABCE1 interactions 2.855E-4 5.646E-3 4.034E-2
2.032E-1
 3 243
37 int:ARFGEF2 ARFGEF2 interactions 3.063E-4 5.894E-3 4.212E-2
2.181E-1
 2 47
38 int:SAP30BP SAP30BP interactions 3.330E-4 6.239E-3 4.458E-2
2.371E-1
 2 49
39 int:LIMA1 LIMA1 interactions 3.723E-4 6.424E-3 4.591E-2
2.651E-1
 3 266
40 int:CAPZA2 CAPZA2 interactions 3.847E-4 6.424E-3 4.591E-2
2.739E-1
 3 269
41 int:RNF123 RNF123 interactions 3.897E-4 6.424E-3 4.591E-2
2.775E-1
 2 53
42 int:BASP1 BASP1 interactions 3.897E-4 6.424E-3 4.591E-2
2.775E-1
 2 53
43 int:CDC73 CDC73 interactions 3.974E-4 6.424E-3 4.591E-2
2.830E-1
 3 272
44 int:PLEKHO1 PLEKHO1 interactions 4.046E-4 6.424E-3 4.591E-2
2.881E-1
 2 54
45 int:SPDL1 SPDL1 interactions 4.060E-4 6.424E-3 4.591E-2
2.891E-1
 3 274
46 int:PRKCA PRKCA interactions 4.417E-4 6.837E-3 4.886E-2
3.145E-1
 3 282
47 int:ITGB3 ITGB3 interactions 4.995E-4 7.567E-3
5.408E-2
3.557E-1
 2 60
48 int:ITGB5 ITGB5 interactions 5.163E-4 7.658E-3
5.473E-2
3.676E-1
 2 61
49 int:NMD3 NMD3 interactions 6.413E-4 9.133E-3
6.526E-2
4.566E-1
 2 68
50 int:TXNL1 TXNL1 interactions 6.413E-4 9.133E-3
6.526E-2
4.566E-1
 2 68
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q32-q35 7q32-q35 2.885E-4 2.885E-3 8.450E-3 2.885E-3 1 1
2 7p15-p13 7p15-p13 8.653E-4 4.327E-3 1.267E-2 8.653E-3 1 3
3 2q12.2 2q12.2 2.882E-3 7.924E-3 2.321E-2 2.882E-2 1 10
4 3q13 3q13 3.169E-3 7.924E-3 2.321E-2 3.169E-2 1 11
5 6q14.1 6q14.1 7.190E-3 1.198E-2 3.510E-2
7.190E-2
 1 25
6 12q24 12q24 7.190E-3 1.198E-2 3.510E-2
7.190E-2
 1 25
7 3p14.3 3p14.3 8.623E-3 1.232E-2 3.608E-2
8.623E-2
 1 30
8 2q13 2q13 2.030E-2 2.318E-2
6.790E-2
2.030E-1
 1 71
9 1p36.21 1p36.21 2.087E-2 2.318E-2
6.790E-2
2.087E-1
 1 73
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 83 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1218 LIM domain containing genenames.org 1.027E-4 5.137E-4 1.173E-3 5.137E-4 2 59
2 279 Calcium sensing receptors genenames.org 5.496E-4 1.374E-3 3.137E-3 2.748E-3 1 2
3 389 RAS type GTPase family genenames.org 8.491E-3 1.415E-2 3.231E-2 4.246E-2 1 31
4 741 SH2 domain containing genenames.org 2.745E-2 3.432E-2
7.836E-2
1.373E-1
 1 101

13: Coexpression [Display Chart] 10 input genes in category / 1123 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14673169-TableA1-1 Human Breast Hendricks04 71genes BRG1 up GeneSigDB 1.347E-6 8.941E-4 6.796E-3 1.512E-3 3 53
2 M15057 Genes up-regulated in ALAB cells (breast cancer) upon reintroduction of SMARCA4 [GeneID=6597] expressed off adenoviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.592E-6 8.941E-4 6.796E-3 1.788E-3 3 56
3 M3415 Genes up-regulated in comparison of microglia cells 6 h after stimulation with IFNG [GeneID=3458] versus microglia cells 24 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 2.506E-2
1.905E-1
8.200E-2
 3 200
4 M9128 Genes up-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.925E-5 2.506E-2
1.905E-1
1.002E-1
 3 214
5 16597596-TableS3-3 Human Leukemia Wilson06 50genes DifferentialClusterC2 GeneSigDB 1.366E-4 3.069E-2
2.333E-1
1.534E-1
 2 41
6 M12895 Genes down-regulated in basal-like breast cancer cell lines as compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.037E-4 3.812E-2
2.898E-1
2.287E-1
 2 50
7 15342375-Table2 Human Prostate Ashida04 63genes GeneSigDB 2.839E-4 4.555E-2
3.462E-1
3.188E-1
 2 59
Show 2 more annotations

14: Coexpression Atlas [Display Chart] 10 input genes in category / 858 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/2 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/2 TCGA-Stomach 4.141E-5 4.360E-3 3.197E-2 3.553E-2 3 156
2 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 1000 k3 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.383E-5 4.360E-3 3.197E-2 3.761E-2 3 159
3 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Overall Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Overall Top 200 Genes 6.237E-5 4.360E-3 3.197E-2
5.351E-2
 3 179
4 gudmap kidney adult JuxtaGlom Ren1 Captopr k4 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.237E-5 4.360E-3 3.197E-2
5.351E-2
 3 179
5 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Overall Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Overall Top 200 Genes 6.446E-5 4.360E-3 3.197E-2
5.531E-2
 3 181
6 Kidney10XCellRanger Six2KI P0 Stroma Stroma Overall Top 200 Genes Kidney10XCellRanger Six2KI P0 Stroma Stroma Overall Top 200 Genes 6.660E-5 4.360E-3 3.197E-2
5.715E-2
 3 183
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney NephrogenicRest Wilms MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney NephrogenicRest Wilms MNP2 Adult, Development, and Cancer types 7.216E-5 4.360E-3 3.197E-2
6.191E-2
 3 188
8 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/basal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/basal cell Tabula Muris Consortium 7.446E-5 4.360E-3 3.197E-2
6.389E-2
 3 190
9 gudmap developingLowerUrinaryTract P1 bladder B 1000 k1 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.681E-5 4.360E-3 3.197E-2
6.591E-2
 3 192
10 Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma2-C4-KC1 Top 200 Genes Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma2-C4-KC1 Top 200 Genes 7.921E-5 4.360E-3 3.197E-2
6.797E-2
 3 194
11 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma1-C6-KC2 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma1-C6-KC2 Top 200 Genes 8.800E-5 4.360E-3 3.197E-2
7.551E-2
 3 201
12 Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma1-C7-KC4 Top 200 Genes Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma1-C7-KC4 Top 200 Genes 8.800E-5 4.360E-3 3.197E-2
7.551E-2
 3 201
13 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma3-C4-KC4 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma3-C4-KC4 Top 200 Genes 9.062E-5 4.360E-3 3.197E-2
7.776E-2
 3 203
14 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma2-C2-KC2 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma2-C2-KC2 Top 200 Genes 9.062E-5 4.360E-3 3.197E-2
7.776E-2
 3 203
15 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma1-C3-KC2 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma1-C3-KC2 Top 200 Genes 9.195E-5 4.360E-3 3.197E-2
7.890E-2
 3 204
16 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC2 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC2 Top 200 Genes 9.330E-5 4.360E-3 3.197E-2
8.005E-2
 3 205
17 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.740E-5 4.360E-3 3.197E-2
8.357E-2
 3 208
18 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC4 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC4 Top 200 Genes 1.002E-4 4.360E-3 3.197E-2
8.598E-2
 3 210
19 Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma1-C6-KC4 Top 200 Genes Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma1-C6-KC4 Top 200 Genes 1.016E-4 4.360E-3 3.197E-2
8.720E-2
 3 211
20 Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma2-C3-KC1 Top 200 Genes Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma2-C3-KC1 Top 200 Genes 1.016E-4 4.360E-3 3.197E-2
8.720E-2
 3 211
21 Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma2-C6-KC1 Top 200 Genes Kidney10XCellRanger Six2KI P0 Stroma Stroma Subtype P0-Six2KI-Stroma2-C6-KC1 Top 200 Genes 1.213E-4 4.956E-3 3.634E-2
1.041E-1
 3 224
22 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.543E-4 6.019E-3 4.413E-2
1.324E-1
 3 243
23 Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C9-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C9-KC7 Top 200 Genes 1.698E-4 6.335E-3 4.645E-2
1.457E-1
 3 251
24 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC4 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC4 Top 200 Genes 1.800E-4 6.383E-3 4.680E-2
1.544E-1
 3 256
25 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma1-C4-KC4 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma1-C4-KC4 Top 200 Genes 1.927E-4 6.383E-3 4.680E-2
1.654E-1
 3 262
26 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma3-C4-KC2 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma3-C4-KC2 Top 200 Genes 2.060E-4 6.383E-3 4.680E-2
1.768E-1
 3 268
27 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC2 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC2 Top 200 Genes 2.083E-4 6.383E-3 4.680E-2
1.787E-1
 3 269
28 Kidney10XCellRanger Six2KI P0 Stroma Stroma Top 200 Kidney10XCellRanger Six2KI P0 Stroma Stroma Top 200 2.083E-4 6.383E-3 4.680E-2
1.787E-1
 3 269
29 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C9-KC4 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C9-KC4 Top 200 Genes 2.223E-4 6.576E-3 4.822E-2
1.907E-1
 3 275
30 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Col3a1 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Col3a1 Top 200 Genes 2.599E-4 7.407E-3
5.431E-2
2.230E-1
 3 290
31 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Cnn1 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Cnn1 Top 200 Genes 2.679E-4 7.407E-3
5.431E-2
2.298E-1
 3 293
32 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma2-C2-KC4 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma2-C2-KC4 Top 200 Genes 2.871E-4 7.407E-3
5.431E-2
2.463E-1
 3 300
33 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC7 Top 200 Genes 3.014E-4 7.407E-3
5.431E-2
2.586E-1
 3 305
34 BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5 Thalamus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5 Thalamus Top 200 Genes BrainMap 3.043E-4 7.407E-3
5.431E-2
2.611E-1
 3 306
35 BrainMap BrainAtlas - Mouse McCarroll Mural.Acta2.Rgs5.Acta2,Rgs5 Mural.Acta2.Rgs5.Acta2,Rgs5 Subtype Mural.Acta2.Rgs5.Acta2,Rgs5. Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Acta2.Rgs5.Acta2,Rgs5 Mural.Acta2.Rgs5.Acta2,Rgs5 Subtype Mural.Acta2.Rgs5.Acta2,Rgs5. Top 200 Genes BrainMap 3.161E-4 7.407E-3
5.431E-2
2.712E-1
 3 310
36 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.191E-4 7.407E-3
5.431E-2
2.738E-1
 3 311
37 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma2-C2-KC10 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma2-C2-KC10 Top 200 Genes 3.534E-4 7.407E-3
5.431E-2
3.032E-1
 3 322
38 BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5.Cnn1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5.Cnn1 Top 200 Genes BrainMap 3.598E-4 7.407E-3
5.431E-2
3.087E-1
 3 324
39 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/1 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/1 TCGA-Prostate 3.634E-4 7.407E-3
5.431E-2
3.118E-1
 2 63
40 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.730E-4 7.407E-3
5.431E-2
3.200E-1
 3 328
41 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Dendritic Cell Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Dendritic Cell Top 200 Genes 3.797E-4 7.407E-3
5.431E-2
3.258E-1
 3 330
42 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC7 Top 200 Genes 3.865E-4 7.407E-3
5.431E-2
3.316E-1
 3 332
43 Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma3-C4-KC10 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Stroma Stroma Subtype P0-Six2TGC Tsc1-Stroma3-C4-KC10 Top 200 Genes 3.865E-4 7.407E-3
5.431E-2
3.316E-1
 3 332
44 Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C9-KC4 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C9-KC4 Top 200 Genes 3.968E-4 7.407E-3
5.431E-2
3.405E-1
 3 335
45 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.003E-4 7.407E-3
5.431E-2
3.434E-1
 3 336
46 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.073E-4 7.407E-3
5.431E-2
3.495E-1
 3 338
47 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC8 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC8 Top 200 Genes 4.108E-4 7.407E-3
5.431E-2
3.525E-1
 3 339
48 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma1-C3-KC8 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma1-C3-KC8 Top 200 Genes 4.144E-4 7.407E-3
5.431E-2
3.555E-1
 3 340
49 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC8 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma3-C6-KC8 Top 200 Genes 4.325E-4 7.573E-3
5.553E-2
3.711E-1
 3 345
50 BM Top 100 - heart ventricle BM Top 100 - heart ventricle Body Map 4.615E-4 7.910E-3
5.800E-2
3.960E-1
 2 71
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 40 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14260 MODULE 524 Actin cytoskeleton binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.336E-6 3.932E-5 1.682E-4 5.344E-5 3 30
2 M2119 MODULE 419 Genes in the cancer module 419. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.966E-6 3.932E-5 1.682E-4 7.865E-5 3 34
3 M12699 MODULE 202 Genes in the cancer module 202. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.080E-4 2.773E-3 1.186E-2 8.319E-3 2 28
4 M9199 MODULE 3 Genes in the cancer module 3. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.715E-3 2.715E-2
1.162E-1
1.086E-1
 3 385

16: MicroRNA [Display Chart] 10 input genes in category / 323 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-764:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-6 1.713E-3 1.089E-2 1.713E-3 3 258
2 hsa-miR-518e:mirSVR lowEffct hsa-miR-518e:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.009E-5 3.244E-3 2.062E-2 6.488E-3 3 403
3 hsa-miR-2277:mirSVR highEffct hsa-miR-2277:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.324E-4 1.389E-2
8.832E-2
 4.278E-2 2 125
4 hsa-miR-640:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.450E-4 1.389E-2
8.832E-2
1.114E-1
 2 202
5 ACTGCCT,MIR-34B:MSigDB ACTGCCT,MIR-34B:MSigDB MSigDB 3.552E-4 1.389E-2
8.832E-2
1.147E-1
 2 205
6 hsa-miR-3663-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.978E-4 1.389E-2
8.832E-2
1.285E-1
 2 217
7 hsa-miR-31-5p:Functional MTI Functional MTI miRTarbase 4.237E-4 1.389E-2
8.832E-2
1.369E-1
 2 224
8 hsa-miR-6131:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.313E-4 1.389E-2
8.832E-2
1.393E-1
 2 226
9 hsa-miR-1236-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.981E-4 1.389E-2
8.832E-2
1.609E-1
 2 243
10 hsa-miR-455-3p.2:TargetScan hsa-miR-455-3p.2 TargetScan 5.187E-4 1.389E-2
8.832E-2
1.675E-1
 2 248
11 hsa-miR-5006-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.654E-4 1.389E-2
8.832E-2
1.826E-1
 2 259
12 hsa-miR-4755-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.741E-4 1.389E-2
8.832E-2
1.854E-1
 2 261
13 hsa-miR-1224-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.741E-4 1.389E-2
8.832E-2
1.854E-1
 2 261
14 hsa-miR-3934-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.460E-4 1.389E-2
8.832E-2
2.087E-1
 2 277
15 hsa-miR-6790-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.693E-4 1.389E-2
8.832E-2
2.162E-1
 2 282
16 hsa-miR-6821-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.883E-4 1.389E-2
8.832E-2
2.223E-1
 2 286
17 hsa-miR-125a-3p:Functional MTI Functional MTI miRTarbase 8.074E-4 1.534E-2
9.751E-2
2.608E-1
 2 310
18 hsa-miR-378a-5p:Functional MTI Functional MTI miRTarbase 1.246E-3 2.183E-2
1.388E-1
4.023E-1
 2 386
19 hsa-miR-4286:mirSVR highEffct hsa-miR-4286:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.284E-3 2.183E-2
1.388E-1
4.148E-1
 2 392
20 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 1.410E-3 2.242E-2
1.425E-1
4.554E-1
 2 411
21 hsa-miR-4793-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.458E-3 2.242E-2
1.425E-1
4.708E-1
 2 418
22 hsa-miR-1915*:mirSVR highEffct hsa-miR-1915*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.768E-3 2.544E-2
1.617E-1
5.709E-1
 2 461
23 hsa-miR-7703:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-3 2.544E-2
1.617E-1
6.031E-1
 2 474
24 hsa-miR-508-5p:Functional MTI Functional MTI miRTarbase 1.890E-3 2.544E-2
1.617E-1
6.106E-1
 2 477
25 hsa-miR-3199:mirSVR highEffct hsa-miR-3199:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.969E-3 2.544E-2
1.617E-1
6.360E-1
 2 487
26 hsa-miR-563:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.731E-3 4.629E-2
2.942E-1
1.000E0
 1 27
27 hsa-miR-380-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.869E-3 4.629E-2
2.942E-1
1.000E0
 1 28
Show 22 more annotations

17: Drug [Display Chart] 10 input genes in category / 1543 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000023039 Alstonine hydrochloride Stitch 1.492E-5 2.303E-2
1.823E-1
 2.303E-2 3 116
2 1122 UP cytochalasin B; Up 200; 20.8uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 4.928E-5 2.815E-2
2.229E-1
7.604E-2
 3 173
3 CID000128038 AC1L2T2K Stitch 5.575E-5 2.815E-2
2.229E-1
8.603E-2
 2 26
4 CID000211218 40-a Stitch 7.456E-5 2.815E-2
2.229E-1
1.150E-1
 2 30
5 CID000007576 d-dm Stitch 1.140E-4 2.815E-2
2.229E-1
1.758E-1
 2 37
6 CID000446307 Re-Y Stitch 1.203E-4 2.815E-2
2.229E-1
1.856E-1
 2 38
7 CID000004673 pamidronate Stitch 2.007E-4 2.815E-2
2.229E-1
3.096E-1
 2 49
8 CID000001324 (S)-1,2-Diolein Stitch 2.090E-4 2.815E-2
2.229E-1
3.225E-1
 2 50
9 CID000007813 p-toluidine Stitch 4.219E-4 2.815E-2
2.229E-1
6.509E-1
 2 71
10 CID000159724 SN 4094 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
11 CID000159953 SN-6324 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
12 CID006332031 NSC-59270 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
13 CID003016672 dbfA Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
14 CID000081034 Direct Red 46 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
15 CID000162077 Sn 6113 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
16 CID000091539 Pigment Yellow 17 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
17 CID000479653 hexahydrocolupulone Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
18 CID000150136 SN 6053 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
19 CID000167953 Sn 6132 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
20 CID000125712 SN-18071 Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
21 DB01012 Cinacalcet Drug Bank 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
22 CID000008543 W3366A Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
23 CID003013896 1,3,3-trimethylcyclohexene Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
24 CID000071123 gitaloxin Stitch 4.378E-4 2.815E-2
2.229E-1
6.755E-1
 1 1
25 CID000001281 hemi-BABIM Stitch 4.706E-4 2.825E-2
2.237E-1
7.262E-1
 2 75
26 ctd:C540355 1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one CTD 4.760E-4 2.825E-2
2.237E-1
7.345E-1
 3 373
27 CID000123811 Grgds Stitch 5.761E-4 3.292E-2
2.607E-1
8.889E-1
 2 83
28 CID000023981 europium Stitch 6.327E-4 3.487E-2
2.761E-1
9.763E-1
 2 87
29 CID000002088 alendronate Stitch 6.769E-4 3.601E-2
2.852E-1
1.000E0
 2 90
30 CID000069100 2,3-dimethylhydroquinone Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
31 CID000138115 tetrakis(trimethylsilyl)silane Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
32 CID010171263 2-mercaptoglutarate Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
33 CID005491931 4-heptadecyl-7-hydroxycoumarin Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
34 CID000078346 5-carboxypyrimidine Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
35 CID000132768 Sn 6131 Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
36 CID000002862 desglucocheirotoxin Stitch 8.754E-4 3.752E-2
2.971E-1
1.000E0
 1 2
37 ctd:C436740 N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine CTD 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
38 CID006478913 pochonin D Stitch 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
39 CID000146450 SN 6570 Stitch 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
40 ctd:C558527 N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide CTD 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
41 CID000159956 SN 5754 Stitch 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
42 CID000015969 swep Stitch 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
43 CID005024764 CGP7930 Stitch 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
44 CID000069560 DMHQ Stitch 1.313E-3 4.598E-2
3.641E-1
1.000E0
 1 3
45 CID002723790 thiourea Stitch 1.362E-3 4.598E-2
3.641E-1
1.000E0
 2 128
46 CID000522237 hexahydrocannabinol Stitch 1.750E-3 4.598E-2
3.641E-1
1.000E0
 1 4
47 CID006335025 AC1O3R10 Stitch 1.750E-3 4.598E-2
3.641E-1
1.000E0
 1 4
48 CID000008661 atRal Stitch 1.750E-3 4.598E-2
3.641E-1
1.000E0
 1 4
49 ctd:D000069449 Cinacalcet Hydrochloride CTD 1.750E-3 4.598E-2
3.641E-1
1.000E0
 1 4
50 ctd:D011744 Pyrimidinones CTD 1.750E-3 4.598E-2
3.641E-1
1.000E0
 1 4
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 971 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0265609 Accessory carpal bone DisGeNET Curated 3.427E-7 1.664E-4 1.241E-3 3.328E-4 2 2
2 C1835574 Delayed coalescence of calcaneal ossification centers DisGeNET Curated 3.427E-7 1.664E-4 1.241E-3 3.328E-4 2 2
3 C0410189 Muscular Dystrophy, Emery-Dreifuss DisGeNET Curated 6.132E-7 1.985E-4 1.480E-3 5.954E-4 3 29
4 C3887527 Fused cervical vertebrae DisGeNET Curated 3.424E-6 8.018E-4 5.978E-3 3.325E-3 2 5
5 C0426790 Narrow thorax DisGeNET Curated 4.129E-6 8.018E-4 5.978E-3 4.009E-3 3 54
6 C1836186 Fibular aplasia DisGeNET Curated 5.134E-6 8.309E-4 6.195E-3 4.986E-3 2 6
7 C1859680 Broad face DisGeNET Curated 7.186E-6 8.722E-4 6.503E-3 6.977E-3 2 7
8 C0038018 Spondylolysis DisGeNET Curated 7.186E-6 8.722E-4 6.503E-3 6.977E-3 2 7
9 C1859399 Radial bowing DisGeNET Curated 2.664E-5 2.874E-3 2.143E-2 2.586E-2 2 13
10 C1832117 Short upper arms DisGeNET Curated 4.094E-5 3.465E-3 2.583E-2 3.975E-2 2 16
11 C3713420 Familial Hyperaldosteronism DisGeNET BeFree 4.094E-5 3.465E-3 2.583E-2 3.975E-2 2 16
12 C4021785 Abnormality of the metacarpal bones DisGeNET Curated 4.638E-5 3.465E-3 2.583E-2 4.504E-2 2 17
13 C0595939 Stillbirth DisGeNET Curated 4.638E-5 3.465E-3 2.583E-2 4.504E-2 2 17
14 C1837081 Tibial bowing DisGeNET Curated 6.474E-5 4.490E-3 3.348E-2
6.286E-2
 2 20
15 C1849020 Short metatarsal DisGeNET Curated 7.153E-5 4.493E-3 3.350E-2
6.945E-2
 2 21
16 C1853737 Prominent occiput DisGeNET Curated 7.865E-5 4.493E-3 3.350E-2
7.637E-2
 2 22
17 C4280652 Prominent back of the head DisGeNET Curated 7.865E-5 4.493E-3 3.350E-2
7.637E-2
 2 22
18 C1840069 Sandal gap DisGeNET Curated 9.391E-5 4.952E-3 3.692E-2
9.119E-2
 2 24
19 C0085602 Polydipsia DisGeNET Curated 1.020E-4 4.952E-3 3.692E-2
9.909E-2
 2 25
20 C0795690 Congenital omphalocele DisGeNET Curated 1.285E-4 4.952E-3 3.692E-2
1.247E-1
 2 28
21 C0426891 Broad thumbs DisGeNET Curated 1.285E-4 4.952E-3 3.692E-2
1.247E-1
 2 28
22 C0032617 Polyuria DisGeNET Curated 1.579E-4 4.952E-3 3.692E-2
1.533E-1
 2 31
23 C3714506 Meckel syndrome type 1 DisGeNET Curated 1.683E-4 4.952E-3 3.692E-2
1.634E-1
 2 32
24 C0030554 Paresthesia DisGeNET Curated 2.135E-4 4.952E-3 3.692E-2
2.073E-1
 2 36
25 C0019825 Hoarseness DisGeNET Curated 2.381E-4 4.952E-3 3.692E-2
2.312E-1
 2 38
26 C1837084 Short metacarpal DisGeNET Curated 3.198E-4 4.952E-3 3.692E-2
3.105E-1
 2 44
27 C0431904 Ulnar polydactyly of fingers DisGeNET Curated 3.651E-4 4.952E-3 3.692E-2
3.545E-1
 2 47
28 C4025814 Abnormality of the metaphyses DisGeNET Curated 3.808E-4 4.952E-3 3.692E-2
3.698E-1
 2 48
29 C1839829 Short distal phalanges DisGeNET Curated 4.133E-4 4.952E-3 3.692E-2
4.013E-1
 2 50
30 C1853241 Flat face DisGeNET Curated 4.471E-4 4.952E-3 3.692E-2
4.341E-1
 2 52
31 C0025995 Micromelia DisGeNET Curated 5.952E-4 4.952E-3 3.692E-2
5.779E-1
 2 60
32 C0850826 Localized Skin Lesion DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
33 cv:C1845902 FG syndrome 2 Clinical Variations 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
34 OMIN:108721 ATELOSTEOGENESIS, TYPE III; AOIII OMIM 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
35 C1862421 Widened distal phalanges DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
36 C1862428 Thoracic platyspondyly DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
37 C4273726 Congenital dysplasia of cardiac valve DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
38 OMIN:272460 SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME; SCT OMIM 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
39 OMIN:300244 TERMINAL OSSEOUS DYSPLASIA; TOD OMIM 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
40 C3668942 Atelosteogenesis Type 3 DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
41 C1850631 Short 3rd metacarpals DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
42 OMIN:300537 HETEROTOPIA, PERIVENTRICULAR, EHLERS-DANLOS VARIANT OMIM 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
43 C4021189 Underdeveloped superior crus of antihelix DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
44 C4025010 Coat hanger sign of ribs DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
45 cv:C0403553 Senior-Loken syndrome 1 Clinical Variations 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
46 C0265669 Congenital dislocation of knee DisGeNET BeFree 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
47 cv:C1848934 Spondylocarpotarsal synostosis syndrome Clinical Variations 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
48 C4023288 Short chordae tendineae of the mitral valve DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
49 C4025049 Distal tapering femur DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
50 C1839830 Hirsute forehead DisGeNET Curated 6.171E-4 4.952E-3 3.692E-2
5.992E-1
 1 1
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