Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc98_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 30 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 2.754E-5 8.263E-4 3.301E-3 8.263E-4 4 365
2 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 7.540E-4 4.592E-3 1.835E-2 2.262E-2 3 357
3 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 8.969E-4 4.592E-3 1.835E-2 2.691E-2 3 379
4 GO:0000987 proximal promoter sequence-specific DNA binding 1.034E-3 4.592E-3 1.835E-2 3.101E-2 3 398
5 GO:0004637 phosphoribosylamine-glycine ligase activity 1.071E-3 4.592E-3 1.835E-2 3.214E-2 1 2
6 GO:0004905 type I interferon receptor activity 1.071E-3 4.592E-3 1.835E-2 3.214E-2 1 2
7 GO:0019962 type I interferon binding 1.071E-3 4.592E-3 1.835E-2 3.214E-2 1 2
8 GO:0019961 interferon binding 1.607E-3 6.026E-3 2.407E-2 4.821E-2 1 3
9 GO:0004904 interferon receptor activity 2.677E-3 8.923E-3 3.565E-2
8.030E-2
 1 5
10 GO:0001047 core promoter binding 3.298E-3 9.895E-3 3.953E-2
9.895E-2
 2 164
11 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 8.023E-3 2.188E-2
8.742E-2
2.407E-1
 2 259
12 GO:0005132 type I interferon receptor binding 9.075E-3 2.269E-2
9.063E-2
2.722E-1
 1 17
Show 7 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 438 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060337 type I interferon signaling pathway 1.362E-24 3.396E-22 2.262E-21 5.965E-22 10 81
2 GO:0071357 cellular response to type I interferon 1.551E-24 3.396E-22 2.262E-21 6.793E-22 10 82
3 GO:0034340 response to type I interferon 2.567E-24 3.748E-22 2.496E-21 1.124E-21 10 86
4 GO:0060333 interferon-gamma-mediated signaling pathway 6.000E-18 6.570E-16 4.376E-15 2.628E-15 8 85
5 GO:0071346 cellular response to interferon-gamma 3.703E-16 3.244E-14 2.161E-13 1.622E-13 8 140
6 GO:0034341 response to interferon-gamma 1.285E-15 9.377E-14 6.246E-13 5.626E-13 8 163
7 GO:0042089 cytokine biosynthetic process 1.297E-11 7.858E-10 5.234E-9 5.683E-9 6 120
8 GO:0042107 cytokine metabolic process 1.435E-11 7.858E-10 5.234E-9 6.286E-9 6 122
9 GO:0045351 type I interferon biosynthetic process 5.705E-11 2.777E-9 1.849E-8 2.499E-8 4 15
10 GO:0032728 positive regulation of interferon-beta production 1.496E-9 6.554E-8 4.366E-7 6.554E-7 4 32
11 GO:0032606 type I interferon production 2.405E-9 9.575E-8 6.377E-7 1.053E-6 5 119
12 GO:0060338 regulation of type I interferon-mediated signaling pathway 3.795E-9 1.385E-7 9.227E-7 1.662E-6 4 40
13 GO:0051607 defense response to virus 7.375E-9 2.485E-7 1.655E-6 3.230E-6 6 343
14 GO:0032648 regulation of interferon-beta production 8.064E-9 2.523E-7 1.680E-6 3.532E-6 4 48
15 GO:0032608 interferon-beta production 9.539E-9 2.785E-7 1.855E-6 4.178E-6 4 50
16 GO:0045088 regulation of innate immune response 1.257E-8 3.440E-7 2.291E-6 5.505E-6 6 375
17 GO:0001819 positive regulation of cytokine production 2.401E-8 6.187E-7 4.121E-6 1.052E-5 6 418
18 GO:0009615 response to virus 2.764E-8 6.726E-7 4.480E-6 1.211E-5 6 428
19 GO:0032481 positive regulation of type I interferon production 4.237E-8 9.768E-7 6.506E-6 1.856E-5 4 72
20 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway 2.595E-7 5.683E-6 3.785E-5 1.137E-4 2 2
21 GO:0032479 regulation of type I interferon production 3.018E-7 6.295E-6 4.193E-5 1.322E-4 4 117
22 GO:0002224 toll-like receptor signaling pathway 3.812E-7 7.590E-6 5.055E-5 1.670E-4 4 124
23 GO:0001959 regulation of cytokine-mediated signaling pathway 6.754E-7 1.286E-5 8.566E-5 2.958E-4 4 143
24 GO:0060759 regulation of response to cytokine stimulus 7.962E-7 1.453E-5 9.678E-5 3.487E-4 4 149
25 GO:0002221 pattern recognition receptor signaling pathway 1.168E-6 2.047E-5 1.363E-4 5.117E-4 4 164
26 GO:0034121 regulation of toll-like receptor signaling pathway 2.575E-6 4.338E-5 2.890E-4 1.128E-3 3 53
27 GO:0002758 innate immune response-activating signal transduction 6.053E-6 9.819E-5 6.540E-4 2.651E-3 4 248
28 GO:0002218 activation of innate immune response 6.864E-6 1.074E-4 7.151E-4 3.006E-3 4 256
29 GO:1902105 regulation of leukocyte differentiation 9.109E-6 1.317E-4 8.774E-4 3.990E-3 4 275
30 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 9.109E-6 1.317E-4 8.774E-4 3.990E-3 4 275
31 GO:0039530 MDA-5 signaling pathway 9.324E-6 1.317E-4 8.774E-4 4.084E-3 2 9
32 GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1.165E-5 1.595E-4 1.062E-3 5.103E-3 2 10
33 GO:0045089 positive regulation of innate immune response 1.371E-5 1.819E-4 1.212E-3 6.003E-3 4 305
34 GO:0002286 T cell activation involved in immune response 1.601E-5 2.062E-4 1.374E-3 7.012E-3 3 97
35 GO:0002829 negative regulation of type 2 immune response 1.708E-5 2.078E-4 1.384E-3 7.481E-3 2 12
36 GO:0071888 macrophage apoptotic process 1.708E-5 2.078E-4 1.384E-3 7.481E-3 2 12
37 GO:0042035 regulation of cytokine biosynthetic process 2.210E-5 2.616E-4 1.742E-3 9.679E-3 3 108
38 GO:0002698 negative regulation of immune effector process 2.737E-5 3.155E-4 2.101E-3 1.199E-2 3 116
39 GO:1903706 regulation of hemopoiesis 2.929E-5 3.289E-4 2.191E-3 1.283E-2 4 370
40 GO:0032727 positive regulation of interferon-alpha production 3.952E-5 4.328E-4 2.883E-3 1.731E-2 2 18
41 GO:0002250 adaptive immune response 4.052E-5 4.329E-4 2.883E-3 1.775E-2 4 402
42 GO:0045580 regulation of T cell differentiation 4.213E-5 4.393E-4 2.926E-3 1.845E-2 3 134
43 GO:0002683 negative regulation of immune system process 4.809E-5 4.883E-4 3.252E-3 2.106E-2 4 420
44 GO:0032656 regulation of interleukin-13 production 4.905E-5 4.883E-4 3.252E-3 2.149E-2 2 20
45 GO:0002819 regulation of adaptive immune response 5.114E-5 4.884E-4 3.253E-3 2.240E-2 3 143
46 GO:0031349 positive regulation of defense response 5.129E-5 4.884E-4 3.253E-3 2.247E-2 4 427
47 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 5.420E-5 5.051E-4 3.364E-3 2.374E-2 2 21
48 GO:0032647 regulation of interferon-alpha production 5.961E-5 5.328E-4 3.549E-3 2.611E-2 2 22
49 GO:0032616 interleukin-13 production 5.961E-5 5.328E-4 3.549E-3 2.611E-2 2 22
50 GO:0006925 inflammatory cell apoptotic process 6.526E-5 5.605E-4 3.733E-3 2.859E-2 2 23
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 10 input genes in category / 13 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 6 input genes in category / 256 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 9 input genes in category / 444 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002418 increased susceptibility to viral infection 1.734E-12 7.699E-10 5.139E-9 7.699E-10 7 133
2 MP:0020185 altered susceptibility to viral infection 1.552E-11 3.446E-9 2.300E-8 6.893E-9 7 181
3 MP:0008563 decreased interferon-alpha secretion 3.302E-9 4.065E-7 2.713E-6 1.466E-6 4 25
4 MP:0008565 decreased interferon-beta secretion 3.901E-9 4.065E-7 2.713E-6 1.732E-6 4 26
5 MP:0008557 abnormal interferon-alpha secretion 4.578E-9 4.065E-7 2.713E-6 2.032E-6 4 27
6 MP:0002406 increased susceptibility to infection 9.191E-9 6.754E-7 4.508E-6 4.081E-6 7 449
7 MP:0008558 abnormal interferon-beta secretion 1.065E-8 6.754E-7 4.508E-6 4.728E-6 4 33
8 MP:0008555 abnormal interferon secretion 6.458E-8 3.584E-6 2.392E-5 2.867E-5 6 320
9 MP:0002412 increased susceptibility to bacterial infection 1.158E-6 5.711E-5 3.812E-4 5.140E-4 5 262
10 MP:0008548 abnormal circulating interferon level 1.355E-6 6.014E-5 4.014E-4 6.014E-4 4 108
11 MP:0008750 abnormal interferon level 3.026E-6 1.221E-4 8.151E-4 1.343E-3 4 132
12 MP:0010210 abnormal circulating cytokine level 3.838E-6 1.370E-4 9.142E-4 1.704E-3 5 334
13 MP:0020186 altered susceptibility to bacterial infection 4.011E-6 1.370E-4 9.142E-4 1.781E-3 5 337
14 MP:0008713 abnormal cytokine level 1.465E-5 4.645E-4 3.100E-3 6.503E-3 5 439
15 MP:0008835 abnormal intercellular signaling peptide or protein level 1.689E-5 4.998E-4 3.336E-3 7.497E-3 5 452
16 MP:0004795 decreased anti-nuclear antigen antibody level 3.011E-5 8.356E-4 5.577E-3 1.337E-2 2 10
17 MP:0000702 enlarged lymph nodes 3.566E-5 9.314E-4 6.216E-3 1.583E-2 4 246
18 MP:0001191 abnormal skin condition 4.990E-5 1.231E-3 8.215E-3 2.216E-2 4 268
19 MP:0008124 decreased plasmacytoid dendritic cell number 8.008E-5 1.871E-3 1.249E-2 3.555E-2 2 16
20 MP:0000701 abnormal lymph node size 8.486E-5 1.884E-3 1.257E-2 3.768E-2 4 307
21 MP:0003726 decreased autoantibody level 1.266E-4 2.607E-3 1.740E-2
5.619E-2
 2 20
22 MP:0002460 decreased immunoglobulin level 1.292E-4 2.607E-3 1.740E-2
5.735E-2
 4 342
23 MP:0008550 abnormal circulating interferon-beta level 1.537E-4 2.909E-3 1.941E-2
6.826E-2
 2 22
24 MP:0001806 decreased IgM level 1.572E-4 2.909E-3 1.941E-2
6.981E-2
 3 131
25 MP:0013701 abnormal mature B cell number 1.752E-4 3.112E-3 2.077E-2
7.780E-2
 4 370
26 MP:0008123 abnormal plasmacytoid dendritic cell number 2.885E-4 4.926E-3 3.288E-2
1.281E-1
 2 30
27 MP:0002339 abnormal lymph node morphology 3.073E-4 5.053E-3 3.373E-2
1.364E-1
 4 428
28 MP:0004242 abnormal plasmacytoid dendritic cell morphology 3.286E-4 5.211E-3 3.478E-2
1.459E-1
 2 32
29 MP:0003132 increased pre-B cell number 3.937E-4 5.826E-3 3.889E-2
1.748E-1
 2 35
30 MP:0008590 abnormal circulating interleukin-10 level 3.937E-4 5.826E-3 3.889E-2
1.748E-1
 2 35
31 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality 4.894E-4 7.009E-3 4.678E-2
2.173E-1
 2 39
32 MP:0008568 abnormal interleukin secretion 5.363E-4 7.442E-3 4.967E-2
2.381E-1
 4 495
33 MP:0008658 decreased interleukin-1 beta secretion 5.679E-4 7.640E-3
5.099E-2
2.521E-1
 2 42
34 MP:0020180 abnormal IgM level 9.656E-4 1.235E-2
8.244E-2
4.287E-1
 3 243
35 MP:0004977 increased B-1 B cell number 9.737E-4 1.235E-2
8.244E-2
4.323E-1
 2 55
36 MP:0005070 impaired natural killer cell mediated cytotoxicity 1.082E-3 1.335E-2
8.910E-2
4.806E-1
 2 58
37 MP:0001805 decreased IgG level 1.188E-3 1.426E-2
9.515E-2
5.275E-1
 3 261
38 MP:0011719 abnormal natural killer cell mediated cytotoxicity 1.236E-3 1.444E-2
9.638E-2
5.488E-1
 2 62
39 MP:0008559 abnormal interferon-gamma secretion 1.411E-3 1.607E-2
1.072E-1
6.266E-1
 3 277
40 MP:0008211 decreased mature B cell number 1.486E-3 1.650E-2
1.101E-1
6.598E-1
 3 282
41 MP:0001802 arrested B cell differentiation 1.663E-3 1.758E-2
1.173E-1
7.384E-1
 2 72
42 MP:0008476 increased spleen red pulp amount 1.663E-3 1.758E-2
1.173E-1
7.384E-1
 2 72
43 MP:0008071 absent B cells 1.709E-3 1.765E-2
1.178E-1
7.589E-1
 2 73
44 MP:0008096 abnormal plasma cell number 1.900E-3 1.917E-2
1.279E-1
8.434E-1
 2 77
45 MP:0008127 decreased dendritic cell number 1.949E-3 1.923E-2
1.283E-1
8.652E-1
 2 78
46 MP:0005014 increased B cell number 2.355E-3 2.261E-2
1.509E-1
1.000E0
 3 331
47 MP:0000223 decreased monocyte cell number 2.529E-3 2.261E-2
1.509E-1
1.000E0
 2 89
48 MP:0008656 abnormal interleukin-1 beta secretion 2.529E-3 2.261E-2
1.509E-1
1.000E0
 2 89
49 MP:0008608 increased circulating interleukin-13 level 2.605E-3 2.261E-2
1.509E-1
1.000E0
 1 3
50 MP:0013531 abnormal periderm development 2.605E-3 2.261E-2
1.509E-1
1.000E0
 1 3
Show 45 more annotations

6: Domain [Display Chart] 10 input genes in category / 32 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00605 IRF Pfam 1.077E-27 5.746E-27 2.332E-26 3.447E-26 8 9
2 SM00348 IRF SMART 1.077E-27 5.746E-27 2.332E-26 3.447E-26 8 9
3 IPR001346 Interferon reg fact DNA-bd dom InterPro 1.077E-27 5.746E-27 2.332E-26 3.447E-26 8 9
4 IPR019817 Interferon reg fac CS InterPro 1.077E-27 5.746E-27 2.332E-26 3.447E-26 8 9
5 PS00601 IRF 1 PROSITE 1.077E-27 5.746E-27 2.332E-26 3.447E-26 8 9
6 PS51507 IRF 2 PROSITE 1.077E-27 5.746E-27 2.332E-26 3.447E-26 8 9
7 PF10401 IRF-3 Pfam 2.449E-20 8.708E-20 3.534E-19 7.837E-19 6 7
8 SM01243 IRF-3 SMART 2.449E-20 8.708E-20 3.534E-19 7.837E-19 6 7
9 IPR019471 Interferon reg factor-3 InterPro 2.449E-20 8.708E-20 3.534E-19 7.837E-19 6 7
10 IPR017855 SMAD dom-like InterPro 2.797E-17 8.137E-17 3.302E-16 8.951E-16 6 16
11 2.60.200.10 - Gene3D 2.797E-17 8.137E-17 3.302E-16 8.951E-16 6 16
12 1.10.10.10 - Gene3D 1.304E-14 3.476E-14 1.411E-13 4.172E-13 8 218
13 IPR011991 WHTH DNA-bd dom InterPro 3.142E-14 7.734E-14 3.139E-13 1.005E-12 8 243
14 IPR008984 SMAD FHA domain InterPro 7.064E-14 1.615E-13 6.553E-13 2.261E-12 6 52
15 IPR017431 IRF1/IRF2 InterPro 2.564E-7 5.470E-7 2.220E-6 8.206E-6 2 2
16 IPR031218 IRF2 InterPro 5.338E-4 9.489E-4 3.851E-3 1.708E-2 1 1
17 IPR016669 Interferon alpha/beta rcpt-1 InterPro 5.338E-4 9.489E-4 3.851E-3 1.708E-2 1 1
18 IPR031215 IRF1 InterPro 5.338E-4 9.489E-4 3.851E-3 1.708E-2 1 1
19 PF09294 Interfer-bind Pfam 5.326E-3 8.522E-3 3.459E-2
1.704E-1
 1 10
20 IPR015373 Interferon/interleukin rcp dom InterPro 5.326E-3 8.522E-3 3.459E-2
1.704E-1
 1 10
21 IPR001187 Tissue factor InterPro 6.388E-3 9.292E-3 3.771E-2
2.044E-1
 1 12
22 PF01108 Tissue fac Pfam 6.388E-3 9.292E-3 3.771E-2
2.044E-1
 1 12
23 PF00143 Interferon Pfam 9.039E-3 1.113E-2 4.515E-2
2.893E-1
 1 17
24 PS00252 INTERFERON A B D PROSITE 9.039E-3 1.113E-2 4.515E-2
2.893E-1
 1 17
25 SM00076 IFabd SMART 9.039E-3 1.113E-2 4.515E-2
2.893E-1
 1 17
26 IPR000471 Interferon alpha/beta/delta InterPro 9.039E-3 1.113E-2 4.515E-2
2.893E-1
 1 17
27 1.20.1250.10 - Gene3D 2.638E-2 3.074E-2
1.248E-1
8.440E-1
 1 50
28 IPR012351 4 helix cytokine core InterPro 2.690E-2 3.074E-2
1.248E-1
8.607E-1
 1 51
29 IPR009079 4 helix cytokine-like core InterPro 3.881E-2 4.283E-2
1.738E-1
1.000E0
 1 74
Show 24 more annotations

7: Pathway [Display Chart] 10 input genes in category / 67 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269312 Interferon alpha/beta signaling BioSystems: REACTOME 1.384E-23 9.273E-22 4.441E-21 9.273E-22 10 69
2 1269311 Interferon Signaling BioSystems: REACTOME 1.012E-18 3.389E-17 1.623E-16 6.779E-17 10 202
3 1269314 Interferon gamma signaling BioSystems: REACTOME 3.464E-16 7.736E-15 3.705E-14 2.321E-14 8 94
4 1269262 TRAF6 mediated IRF7 activation BioSystems: REACTOME 3.252E-11 5.447E-10 2.609E-9 2.179E-9 5 35
5 173973 Hepatitis C BioSystems: KEGG 2.454E-10 3.289E-9 1.575E-8 1.644E-8 6 131
6 1269259 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways BioSystems: REACTOME 3.042E-9 3.397E-8 1.627E-7 2.038E-7 5 84
7 213306 Measles BioSystems: KEGG 3.235E-8 3.096E-7 1.483E-6 2.167E-6 5 134
8 1269377 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 7.166E-8 6.001E-7 2.874E-6 4.801E-6 5 157
9 122191 NOD-like receptor signaling pathway BioSystems: KEGG 1.067E-7 7.804E-7 3.738E-6 7.150E-6 5 170
10 217173 Influenza A BioSystems: KEGG 1.165E-7 7.804E-7 3.738E-6 7.804E-6 5 173
11 377873 Herpes simplex infection BioSystems: KEGG 1.628E-7 9.919E-7 4.750E-6 1.091E-5 5 185
12 83076 Toll-like receptor signaling pathway BioSystems: KEGG 9.284E-7 5.184E-6 2.483E-5 6.220E-5 4 104
13 694606 Hepatitis B BioSystems: KEGG 3.415E-6 1.760E-5 8.430E-5 2.288E-4 4 144
14 125137 Cytosolic DNA-sensing pathway BioSystems: KEGG 1.515E-5 7.252E-5 3.473E-4 1.015E-3 3 64
15 117292 RIG-I-like receptor signaling pathway BioSystems: KEGG 1.986E-5 8.728E-5 4.180E-4 1.331E-3 3 70
16 M19336 Type I Interferon (alpha/beta IFN) Pathway MSigDB C2 BIOCARTA (v6.0) 2.084E-5 8.728E-5 4.180E-4 1.396E-3 2 9
17 218111 Pertussis BioSystems: KEGG 2.544E-5 1.003E-4 4.802E-4 1.704E-3 3 76
18 M2602 Bone Remodelling MSigDB C2 BIOCARTA (v6.0) 5.257E-5 1.957E-4 9.372E-4 3.522E-3 2 14
19 1269260 TRAF3-dependent IRF activation pathway BioSystems: REACTOME 6.927E-5 2.443E-4 1.170E-3 4.641E-3 2 16
20 1269222 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon BioSystems: REACTOME 8.824E-5 2.956E-4 1.416E-3 5.912E-3 2 18
21 1269313 Regulation of IFNA signaling BioSystems: REACTOME 1.868E-4 5.960E-4 2.854E-3 1.251E-2 2 26
22 83077 Jak-STAT signaling pathway BioSystems: KEGG 2.171E-4 6.611E-4 3.166E-3 1.455E-2 3 156
23 138040 IFN-gamma pathway BioSystems: Pathway Interaction Database 4.456E-4 1.277E-3 6.118E-3 2.986E-2 2 40
24 658418 Viral carcinogenesis BioSystems: KEGG 4.576E-4 1.277E-3 6.118E-3 3.066E-2 3 201
25 1269268 Cytosolic sensors of pathogen-associated DNA BioSystems: REACTOME 1.324E-3 3.548E-3 1.699E-2
8.869E-2
 2 69
26 1269220 MyD88-independent TLR3/TLR4 cascade BioSystems: REACTOME 2.702E-3 6.466E-3 3.097E-2
1.810E-1
 2 99
27 1269221 TRIF-mediated TLR3/TLR4 signaling BioSystems: REACTOME 2.702E-3 6.466E-3 3.097E-2
1.810E-1
 2 99
28 1269219 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 2.702E-3 6.466E-3 3.097E-2
1.810E-1
 2 99
29 1269236 Activated TLR4 signalling BioSystems: REACTOME 3.626E-3 8.378E-3 4.013E-2
2.430E-1
 2 115
30 1269270 IRF3 mediated activation of type 1 IFN BioSystems: REACTOME 4.010E-3 8.956E-3 4.289E-2
2.687E-1
 1 5
31 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 4.336E-3 9.372E-3 4.488E-2
2.905E-1
 2 126
32 193147 Osteoclast differentiation BioSystems: KEGG 4.609E-3 9.496E-3 4.548E-2
3.088E-1
 2 130
33 1269275 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production BioSystems: REACTOME 4.811E-3 9.496E-3 4.548E-2
3.223E-1
 1 6
34 83079 Natural killer cell mediated cytotoxicity BioSystems: KEGG 4.819E-3 9.496E-3 4.548E-2
3.229E-1
 2 133
35 1269204 Toll-Like Receptors Cascades BioSystems: REACTOME 6.329E-3 1.212E-2
5.802E-2
4.240E-1
 2 153
36 1269232 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling BioSystems: REACTOME 9.600E-3 1.787E-2
8.557E-2
6.432E-1
 1 12
37 1269273 IRF3-mediated induction of type I IFN BioSystems: REACTOME 1.040E-2 1.833E-2
8.779E-2
6.966E-1
 1 13
38 1269276 DEx/H-box helicases activate type I IFN and inflammatory cytokines production BioSystems: REACTOME 1.040E-2 1.833E-2
8.779E-2
6.966E-1
 1 13
39 1269277 Regulation of innate immune responses to cytosolic DNA BioSystems: REACTOME 1.199E-2 2.059E-2
9.863E-2
8.032E-1
 1 15
40 1269272 STING mediated induction of host immune responses BioSystems: REACTOME 1.278E-2 2.141E-2
1.025E-1
8.564E-1
 1 16
41 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 1.880E-2 3.072E-2
1.471E-1
1.000E0
 2 270
42 1269269 ZBP1(DAI) mediated induction of type I IFNs BioSystems: REACTOME 1.991E-2 3.176E-2
1.521E-1
1.000E0
 1 25
43 137936 IL12 signaling mediated by STAT4 BioSystems: Pathway Interaction Database 2.227E-2 3.470E-2
1.662E-1
1.000E0
 1 28
44 1269264 Negative regulators of RIG-I/MDA5 signaling BioSystems: REACTOME 2.855E-2 4.348E-2
2.082E-1
1.000E0
 1 36
45 692234 PI3K-Akt signaling pathway BioSystems: KEGG 2.927E-2 4.357E-2
2.087E-1
1.000E0
 2 342
46 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 3.402E-2 4.955E-2
2.373E-1
1.000E0
 1 43
Show 41 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 3237 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22366192 The role of Irf6 in tooth epithelial invagination. Pubmed 1.965E-25 6.361E-22 5.508E-21 6.361E-22 8 23
2 17121613 Mapping of nine porcine interferon regulatory factor genes. Pubmed 4.092E-21 6.624E-18 5.736E-17 1.325E-17 6 9
3 29576451 IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Pubmed 1.887E-18 2.036E-15 1.763E-14 6.107E-15 6 20
4 15800576 IRF-7 is the master regulator of type-I interferon-dependent immune responses. Pubmed 9.374E-17 6.069E-14 5.256E-13 3.034E-13 5 10
5 20637660 Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Pubmed 9.374E-17 6.069E-14 5.256E-13 3.034E-13 5 10
6 23903655 Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Pubmed 1.718E-16 9.271E-14 8.028E-13 5.563E-13 5 11
7 21903422 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Pubmed 3.656E-16 1.691E-13 1.464E-12 1.183E-12 8 283
8 29117564 An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses. Pubmed 1.184E-14 3.834E-12 3.320E-11 3.834E-11 4 5
9 10364426 Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens. Pubmed 1.184E-14 3.834E-12 3.320E-11 3.834E-11 4 5
10 9865487 Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. Pubmed 1.184E-14 3.834E-12 3.320E-11 3.834E-11 4 5
11 20083668 Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. Pubmed 8.288E-14 2.236E-11 1.936E-10 2.683E-10 4 7
12 22252317 Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression. Pubmed 8.288E-14 2.236E-11 1.936E-10 2.683E-10 4 7
13 20422028 Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. Pubmed 1.657E-13 4.127E-11 3.574E-10 5.365E-10 4 8
14 19798431 Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. Pubmed 4.971E-13 1.073E-10 9.290E-10 1.609E-9 4 10
15 20980339 Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway. Pubmed 4.971E-13 1.073E-10 9.290E-10 1.609E-9 4 10
16 22896628 MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7. Pubmed 7.811E-13 1.580E-10 1.368E-9 2.528E-9 4 11
17 25774715 The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Pubmed 1.692E-12 3.222E-10 2.790E-9 5.477E-9 4 13
18 24362933 Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Pubmed 2.368E-12 4.259E-10 3.688E-9 7.666E-9 4 14
19 19858727 Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1. Pubmed 1.292E-11 1.819E-9 1.575E-8 4.184E-8 3 3
20 7768900 Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. Pubmed 1.292E-11 1.819E-9 1.575E-8 4.184E-8 3 3
21 19426920 Expression of interferon regulatory factor 1, 3, and 7 in primary Sjögren syndrome. Pubmed 1.292E-11 1.819E-9 1.575E-8 4.184E-8 3 3
22 10524230 Interferon regulatory factors: the next generation. Pubmed 1.292E-11 1.819E-9 1.575E-8 4.184E-8 3 3
23 27841872 IAP antagonists induce anti-tumor immunity in multiple myeloma. Pubmed 1.292E-11 1.819E-9 1.575E-8 4.184E-8 3 3
24 20331378 Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Pubmed 4.935E-11 5.577E-9 4.830E-8 1.598E-7 5 112
25 17273999 Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Pubmed 5.169E-11 5.577E-9 4.830E-8 1.673E-7 3 4
26 2111015 An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Pubmed 5.169E-11 5.577E-9 4.830E-8 1.673E-7 3 4
27 23975864 Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors. Pubmed 5.169E-11 5.577E-9 4.830E-8 1.673E-7 3 4
28 22379089 West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. Pubmed 5.169E-11 5.577E-9 4.830E-8 1.673E-7 3 4
29 7843405 Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene. Pubmed 5.169E-11 5.577E-9 4.830E-8 1.673E-7 3 4
30 23440417 IRF7-dependent IFN-β production in response to RANKL promotes medullary thymic epithelial cell development. Pubmed 5.169E-11 5.577E-9 4.830E-8 1.673E-7 3 4
31 24014876 IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock. Pubmed 1.292E-10 1.195E-8 1.035E-7 4.183E-7 3 5
32 8550813 Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells. Pubmed 1.292E-10 1.195E-8 1.035E-7 4.183E-7 3 5
33 21266535 IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension. Pubmed 1.292E-10 1.195E-8 1.035E-7 4.183E-7 3 5
34 18955028 Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1. Pubmed 1.292E-10 1.195E-8 1.035E-7 4.183E-7 3 5
35 12799427 Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. Pubmed 1.292E-10 1.195E-8 1.035E-7 4.183E-7 3 5
36 15919906 Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
37 24391507 STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
38 11114377 CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
39 26468541 Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
40 21085181 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
41 23863621 Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
42 11859135 Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
43 22042864 Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription. Pubmed 2.584E-10 1.945E-8 1.684E-7 8.364E-7 3 6
44 23499490 Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death. Pubmed 4.521E-10 3.114E-8 2.696E-7 1.463E-6 3 7
45 23300459 IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. Pubmed 4.521E-10 3.114E-8 2.696E-7 1.463E-6 3 7
46 27565347 Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Pubmed 4.521E-10 3.114E-8 2.696E-7 1.463E-6 3 7
47 27129230 The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene. Pubmed 4.521E-10 3.114E-8 2.696E-7 1.463E-6 3 7
48 26059829 Differential effects of IFN-β on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells. Pubmed 7.233E-10 4.502E-8 3.899E-7 2.341E-6 3 8
49 28100675 Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA. Pubmed 7.233E-10 4.502E-8 3.899E-7 2.341E-6 3 8
50 23770228 Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans. Pubmed 7.233E-10 4.502E-8 3.899E-7 2.341E-6 3 8
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 272 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:IRF8 IRF8 interactions 1.398E-12 3.801E-10 2.351E-9 3.801E-10 5 27
2 int:IRF1 IRF1 interactions 1.267E-8 1.722E-6 1.065E-5 3.445E-6 4 51
3 int:IFNAR2 IFNAR2 interactions 1.054E-7 9.560E-6 5.913E-5 2.868E-5 3 18
4 int:IRF2 IRF2 interactions 7.696E-7 3.753E-5 2.321E-4 2.093E-4 3 34
5 int:TRAF6 TRAF6 interactions 8.278E-7 3.753E-5 2.321E-4 2.252E-4 5 364
6 int:RELA RELA interactions 8.278E-7 3.753E-5 2.321E-4 2.252E-4 5 364
7 int:PRDM1 PRDM1 interactions 1.084E-6 4.211E-5 2.604E-4 2.948E-4 3 38
8 int:SPI1 SPI1 interactions 4.150E-6 1.364E-4 8.438E-4 1.129E-3 3 59
9 int:NFKB1 NFKB1 interactions 4.514E-6 1.364E-4 8.438E-4 1.228E-3 4 219
10 int:IRF6 IRF6 interactions 6.022E-6 1.638E-4 1.013E-3 1.638E-3 2 7
11 int:SOCS1 SOCS1 interactions 1.123E-5 2.698E-4 1.668E-3 3.054E-3 3 82
12 int:IFNA2 IFNA2 interactions 1.289E-5 2.698E-4 1.668E-3 3.507E-3 2 10
13 int:TLX2 TLX2 interactions 1.289E-5 2.698E-4 1.668E-3 3.507E-3 2 10
14 int:IFNA1 IFNA1 interactions 1.890E-5 3.672E-4 2.271E-3 5.140E-3 2 12
15 int:TRIM21 TRIM21 interactions 2.361E-5 4.280E-4 2.647E-3 6.421E-3 3 105
16 int:HOXB8 HOXB8 interactions 3.888E-5 6.610E-4 4.088E-3 1.058E-2 2 17
17 int:KAT2A KAT2A interactions 4.575E-5 7.173E-4 4.436E-3 1.244E-2 3 131
18 int:CREBBP CREBBP interactions 4.747E-5 7.173E-4 4.436E-3 1.291E-2 4 398
19 int:TICAM2 TICAM2 interactions 5.997E-5 8.585E-4 5.309E-3 1.631E-2 2 21
20 int:TBK1 TBK1 interactions 6.320E-5 8.596E-4 5.316E-3 1.719E-2 3 146
21 int:EMX1 EMX1 interactions 7.220E-5 8.927E-4 5.521E-3 1.964E-2 2 23
22 int:MAFB MAFB interactions 7.220E-5 8.927E-4 5.521E-3 1.964E-2 2 23
23 int:DEAF1 DEAF1 interactions 1.000E-4 1.183E-3 7.318E-3 2.721E-2 2 27
24 int:IRF4 IRF4 interactions 1.239E-4 1.404E-3 8.683E-3 3.370E-2 2 30
25 int:IRF2BP1 IRF2BP1 interactions 1.596E-4 1.599E-3 9.889E-3 4.340E-2 2 34
26 int:TLK2 TLK2 interactions 1.596E-4 1.599E-3 9.889E-3 4.340E-2 2 34
27 int:TOP1 TOP1 interactions 1.632E-4 1.599E-3 9.889E-3 4.438E-2 3 201
28 int:IRF5 IRF5 interactions 1.692E-4 1.599E-3 9.889E-3 4.602E-2 2 35
29 int:KAT2B KAT2B interactions 1.705E-4 1.599E-3 9.889E-3 4.637E-2 3 204
30 int:STAT1 STAT1 interactions 1.805E-4 1.637E-3 1.012E-2 4.910E-2 3 208
31 int:IRF9 IRF9 interactions 1.997E-4 1.752E-3 1.084E-2
5.432E-2
 2 38
32 int:IFNAR1 IFNAR1 interactions 2.215E-4 1.882E-3 1.164E-2
6.024E-2
 2 40
33 int:TICAM1 TICAM1 interactions 3.195E-4 2.633E-3 1.629E-2
8.690E-2
 2 48
34 int:TLX3 TLX3 interactions 3.608E-4 2.804E-3 1.734E-2
9.814E-2
 2 51
35 int:IRF7 IRF7 interactions 3.608E-4 2.804E-3 1.734E-2
9.814E-2
 2 51
36 int:CBL CBL interactions 3.931E-4 2.970E-3 1.837E-2
1.069E-1
 3 271
37 int:STAT2 STAT2 interactions 4.046E-4 2.974E-3 1.840E-2
1.100E-1
 2 54
38 int:TANK TANK interactions 4.197E-4 3.004E-3 1.858E-2
1.142E-1
 2 55
39 int:TRMT2A TRMT2A interactions 4.508E-4 3.144E-3 1.945E-2
1.226E-1
 2 57
40 int:STAT6 STAT6 interactions 7.388E-4 5.024E-3 3.107E-2
2.009E-1
 2 73
41 int:MYD88 MYD88 interactions 8.864E-4 5.881E-3 3.637E-2
2.411E-1
 2 80
42 int:GSX1 GSX1 interactions 1.129E-3 7.315E-3 4.524E-2
3.072E-1
 1 2
43 int:IRF3 IRF3 interactions 1.221E-3 7.723E-3 4.777E-2
3.321E-1
 2 94
44 int:MAVS MAVS interactions 1.408E-3 8.702E-3
5.382E-2
3.829E-1
 2 101
45 int:PIAS4 PIAS4 interactions 1.549E-3 9.362E-3
5.790E-2
4.213E-1
 2 106
46 int:TEX36 TEX36 interactions 1.694E-3 1.002E-2
6.194E-2
4.607E-1
 1 3
47 int:USP4 USP4 interactions 1.758E-3 1.017E-2
6.291E-2
4.781E-1
 2 113
48 int:HCFC1 HCFC1 interactions 1.914E-3 1.085E-2
6.709E-2
5.207E-1
 2 118
49 int:UBE2I UBE2I interactions 2.013E-3 1.118E-2
6.912E-2
5.476E-1
 3 476
50 int:IFNW1 IFNW1 interactions 2.258E-3 1.181E-2
7.304E-2
6.141E-1
 1 4
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p25-p23 6p25-p23 2.885E-4 9.617E-4 2.817E-3 2.885E-3 1 1
2 1q32.3-q41 1q32.3-q41 2.885E-4 9.617E-4 2.817E-3 2.885E-3 1 1
3 4q34.1-q35.1 4q34.1-q35.1 2.885E-4 9.617E-4 2.817E-3 2.885E-3 1 1
4 19q13.3-q13.4 19q13.3-q13.4 3.745E-3 9.362E-3 2.742E-2 3.745E-2 1 13
5 9p22 9p22 7.190E-3 1.438E-2 4.212E-2
7.190E-2
 1 25
6 16q24.1 16q24.1 1.034E-2 1.723E-2
5.047E-2
1.034E-1
 1 36
7 21q22.11 21q22.11 1.831E-2 2.325E-2
6.809E-2
1.831E-1
 1 64
8 5q31.1 5q31.1 1.860E-2 2.325E-2
6.809E-2
1.860E-1
 1 65
9 11p15.5 11p15.5 3.605E-2 4.005E-2
1.173E-1
3.605E-1
 1 127
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 43 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$STAT5B 01 V$STAT5B 01 8.729E-7 1.914E-5 8.328E-5 3.754E-5 4 202
2 V$STAT5A 01 V$STAT5A 01 8.904E-7 1.914E-5 8.328E-5 3.829E-5 4 203
3 TTCYNRGAA V$STAT5B 01 TTCYNRGAA V$STAT5B 01 1.916E-4 2.747E-3 1.195E-2 8.240E-3 3 266
4 V$ISRE 01 V$ISRE 01 3.545E-3 2.581E-2
1.123E-1
1.524E-1
 2 188
5 V$IRF Q6 V$IRF Q6 3.545E-3 2.581E-2
1.123E-1
1.524E-1
 2 188
6 V$NFAT Q6 V$NFAT Q6 3.771E-3 2.581E-2
1.123E-1
1.622E-1
 2 194
7 V$STAT Q6 V$STAT Q6 4.202E-3 2.581E-2
1.123E-1
1.807E-1
 2 205
Show 2 more annotations

12: Gene Family [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 599 CD molecules|Interferon receptors genenames.org 5.496E-4 1.099E-3 1.649E-3 1.099E-3 1 5
2 598 Interferons genenames.org 3.515E-3 3.515E-3 5.272E-3 7.029E-3 1 32

13: Coexpression [Display Chart] 10 input genes in category / 1715 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7982 Prmary innate immune response genes induced in 293T cells (embryonic kidney) by overexpression of STING (TMEM173) [GeneID=340061]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.554E-16 4.380E-13 3.515E-12 4.380E-13 5 8
2 19802007-SuppTable1 Human StemCell Novakova10 89genes Interferons/Receptors GeneSigDB 4.898E-14 4.200E-11 3.371E-10 8.400E-11 6 60
3 16270046-SuppTable1 Human Lymphoma Martinez-Delgado05 135genes GeneSigDB 1.564E-12 8.941E-10 7.175E-9 2.682E-9 6 105
4 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v6.0) 7.896E-11 3.386E-8 2.717E-7 1.354E-7 6 200
5 M3347 Genes down-regulated in comparison of dendritic cells (DC) before and 4 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v6.0) 1.089E-8 2.736E-6 2.196E-5 1.868E-5 5 199
6 M9020 Genes down-regulated in lymphoid primed multipotent progenitors: wildtype versus LYL1 [GeneID=4066] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.117E-8 2.736E-6 2.196E-5 1.916E-5 5 200
7 M7652 Genes up-regulated in healthy CD4 [GeneID=920] T cells: germ free versus specific pathogen free. MSigDB C7: Immunologic Signatures (v6.0) 1.117E-8 2.736E-6 2.196E-5 1.916E-5 5 200
8 M1990 Selected genes with immunologic function which were reciprocally changed in evasion and tolerogenic tumor models. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.111E-8 3.620E-6 2.905E-5 3.620E-5 3 14
9 19802007-Table1 Human StemCell Novakova10 22genes GeneSigDB 2.111E-8 3.620E-6 2.905E-5 3.620E-5 3 14
10 M6318 Genes up-regulated in Jurkat cells (T lymphocyte) by IFN1@, and IFNB1 [GeneID=3438;3456] but not by overexpression of a constitutively active form of IRF3 [GeneID=3661]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.111E-8 3.620E-6 2.905E-5 3.620E-5 3 14
11 M3283 Genes up-regulated by tamoxifen [PubChem=5376] in HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [GeneID=1489078]). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.728E-8 7.371E-6 5.915E-5 8.109E-5 3 18
12 M5911 Genes up-regulated in response to alpha interferon proteins. MSigDB H: Hallmark Gene Sets (v6.0) 5.979E-8 8.545E-6 6.857E-5 1.025E-4 4 97
13 M3559 Interferon-inducible genes up-regulated in A549 cells (lung cancer) infected with a respiratory syncytial virus (RSV) that had its NS1 [GeneID=1494468] gene knocked down by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.025E-7 1.352E-5 1.085E-4 1.758E-4 3 23
14 19014521-TableS6b Human Breast Reyal08 159genes GeneSigDB 3.842E-7 4.707E-5 3.777E-4 6.590E-4 4 154
15 19286929-SuppTable2i Mouse Lung Rangasamy09 248genes GeneSigDB 5.444E-7 6.224E-5 4.995E-4 9.336E-4 4 168
16 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 7.763E-7 6.245E-5 5.012E-4 1.331E-3 5 469
17 M6082 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (2h) versus untreated (2h). MSigDB C7: Immunologic Signatures (v6.0) 1.008E-6 6.245E-5 5.012E-4 1.728E-3 4 196
18 16479007-Table3 Human StemCell Jaitin06 49genes GeneSigDB 1.060E-6 6.245E-5 5.012E-4 1.818E-3 3 49
19 M9568 Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.071E-6 6.245E-5 5.012E-4 1.836E-3 4 199
20 M7642 Genes down-regulated in memory CD8 T cells: 1' versus 3'. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
21 M8971 Genes down-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
22 M9030 Genes up-regulated in KLRG1- SELL low [GeneID=10219;6402] T reg: CD69- [GeneID=969] versus CD69+ [GeneID=969]. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
23 M9586 Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
24 M9576 Genes down-regulated in T reg: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
25 M9572 Genes up-regulated in cells from peripheral lymph nodes: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
26 M8967 Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
27 M8969 Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
28 M3350 Genes down-regulated in comparison of dendritic cells (DC) before and 16 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
29 M3861 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
30 M7320 Genes up-regulated in HMC-1 (mast leukemia) cells: incubated with the peptide ALL1 and then treated with Cl-IB-MECA [PubChem=3035850] versus stimulation by T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 6.245E-5 5.012E-4 1.874E-3 4 200
31 M1099 Genes up-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) upon serum deprivation for 22 hr in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.352E-6 7.482E-5 6.004E-4 2.319E-3 4 211
32 18245496-SuppTable3 Human Prostate Wallace08 86genes GeneSigDB 2.504E-6 1.342E-4 1.077E-3 4.294E-3 3 65
33 M3652 Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.709E-6 1.927E-4 1.547E-3 6.360E-3 3 74
34 M5897 Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. MSigDB H: Hallmark Gene Sets (v6.0) 6.046E-6 3.050E-4 2.447E-3 1.037E-2 3 87
35 M13453 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.760E-6 4.783E-4 3.838E-3 1.674E-2 3 102
36 16585964-SuppTable9 Mouse Lung not cancer Thimmulappa06 14genes GeneSigDB 1.107E-5 5.224E-4 4.192E-3 1.899E-2 2 12
37 M5487 Hepatic graft versus host disease (GVHD), day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.127E-5 5.224E-4 4.192E-3 1.933E-2 3 107
38 18547747-Table1 Human Leukemia Mollinedo08 117genes GeneSigDB 1.474E-5 6.651E-4 5.337E-3 2.527E-2 3 117
39 M6162 Genes up-regulated by growing HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [GeneID=1489078]) in extracellular matrix (ECM). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.279E-5 1.002E-3 8.041E-3 3.908E-2 2 17
40 M8244 Genes changed in INA-6 cells (multiple myeloma, MM) by re-addition of IL6 [GeneID=3569] after its initial withdrawal for 12h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.744E-5 1.108E-3 8.892E-3 4.706E-2 3 144
41 M13095 Genes up-regulated specifically in human thymus. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.181E-5 1.108E-3 8.892E-3
5.456E-2
 2 20
42 12747878-Table2 Human Breast Huang03 176genes LNmetastasis GeneSigDB 3.353E-5 1.108E-3 8.892E-3
5.751E-2
 3 154
43 M1221 Genes up-regulated in IEC-18 cells (intestinal epithelial cells) which avoided anoikis (a form of apoptosis) after detachment. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.617E-5 1.108E-3 8.892E-3
7.918E-2
 2 24
44 M6882 Genes up-regulated in monocytes after HCMV infection: untreated versus Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v6.0) 4.826E-5 1.108E-3 8.892E-3
8.276E-2
 3 174
45 12594241-Table5 Human Lymphoma deVos03 25genes GeneSigDB 5.017E-5 1.108E-3 8.892E-3
8.605E-2
 2 25
46 16269622-Table2 Mouse StemCell Biswas06 31genes GeneSigDB 5.017E-5 1.108E-3 8.892E-3
8.605E-2
 2 25
47 16585964-SuppTable3 Mouse Lung not cancer Thimmulappa06 31genes GeneSigDB 5.017E-5 1.108E-3 8.892E-3
8.605E-2
 2 25
48 M8187 Genes down-regulated in B lymphocytes after immunization with: monophosphoryl lipid A versus imiquimod [PubChem=13982876]. MSigDB C7: Immunologic Signatures (v6.0) 5.078E-5 1.108E-3 8.892E-3
8.708E-2
 3 177
49 M7537 Genes up-regulated in double positive thymocytes with ELK1 [GeneID=2002] knockout: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v6.0) 6.568E-5 1.108E-3 8.892E-3
1.126E-1
 3 193
50 M4284 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h. MSigDB C7: Immunologic Signatures (v6.0) 6.670E-5 1.108E-3 8.892E-3
1.144E-1
 3 194
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 771 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM854297 500 Plasmacytoid, DC.pDC.8+.MLN, B220-FITC CD45-APC CD11c-eFluor780 GR1-PE CD8-eFlu, Lymph Node, avg-2 Immgen.org, GSE15907 1.434E-5 6.955E-3
5.025E-2
 1.106E-2 4 410
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/macrophage Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/macrophage Tabula Muris Consortium 4.540E-5 6.955E-3
5.025E-2
 3.500E-2 3 181
3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F7 Adult, Development, and Cancer types 4.846E-5 6.955E-3
5.025E-2
 3.736E-2 3 185
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal VHL RCC Wilms tumour/Kidney Normal VHL RCC T16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal VHL RCC Wilms tumour/Kidney Normal VHL RCC T16 Adult, Development, and Cancer types 4.924E-5 6.955E-3
5.025E-2
 3.796E-2 3 186
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal-Medulla Wilms EN-B/Kidney Normal-Medulla Wilms EN16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal-Medulla Wilms EN-B/Kidney Normal-Medulla Wilms EN16 Adult, Development, and Cancer types 5.164E-5 6.955E-3
5.025E-2
 3.982E-2 3 189
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasmacytoid DC/Kidney Normal VHL RCC Plasmacytoid DC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasmacytoid DC/Kidney Normal VHL RCC Plasmacytoid DC Adult, Development, and Cancer types 5.412E-5 6.955E-3
5.025E-2
 4.173E-2 3 192
7 Lungmap Mouse Lung PND3 Myeloid Subtype Myeloid-B(1) Lungmap Mouse Lung PND3 Myeloid Subtype Myeloid-B(1) Lungmap CCHMC 6.576E-5 7.243E-3
5.234E-2
5.070E-2
 3 205
8 gudmap kidney adult Mesangium Meis k4 1000 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.301E-4 1.253E-2
9.057E-2
1.003E-1
 3 258
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Private/Kidney NephrogenicRest Wilms Private/Kidney NephrogenicRest Wilms IN12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Private/Kidney NephrogenicRest Wilms Private/Kidney NephrogenicRest Wilms IN12 Adult, Development, and Cancer types 2.138E-4 1.654E-2
1.195E-1
1.649E-1
 2 54
10 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Dendritic Cell Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Dendritic Cell Top 200 Genes 2.688E-4 1.654E-2
1.195E-1
2.072E-1
 3 330
11 10X Human 8K PBMC Dendritic Subtype Dendritic-CST3 HLA-DRA HLA-DRB1 Top 200 Genes 10X Human 8K PBMC Dendritic Subtype Dendritic-CST3 HLA-DRA HLA-DRB1 Top 200 Genes 3.851E-4 1.654E-2
1.195E-1
2.969E-1
 3 373
12 10X Human 8K PBMC B cells Subtype B cells-S100A8, LYZ, S100A9 Top 200 Genes 10X Human 8K PBMC B cells Subtype B cells-S100A8, LYZ, S100A9 Top 200 Genes 3.851E-4 1.654E-2
1.195E-1
2.969E-1
 3 373
13 10X Human 8K PBMC Dendritic Subtype Dendritic-CST3 HLA-DRA HLA-DRB1 .1 Top 200 Genes 10X Human 8K PBMC Dendritic Subtype Dendritic-CST3 HLA-DRA HLA-DRB1 .1 Top 200 Genes 3.851E-4 1.654E-2
1.195E-1
2.969E-1
 3 373
14 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-2 (S100A8, LYZ, S100A9) Top 200 Genes 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-2 (S100A8, LYZ, S100A9) Top 200 Genes 3.851E-4 1.654E-2
1.195E-1
2.969E-1
 3 373
15 10X Human 68K PBMC CD4+ T Helper2 Subtype CD4+ T Helper2-CD4+ T Helper2 c6 Top 200 Genes 10X Human 68K PBMC CD4+ T Helper2 Subtype CD4+ T Helper2-CD4+ T Helper2 c6 Top 200 Genes 3.881E-4 1.654E-2
1.195E-1
2.993E-1
 3 374
16 10X Human 8K PBMC B cell Subtype B cell-CD79A HLA-DRA CD79B Top 200 Genes 10X Human 8K PBMC B cell Subtype B cell-CD79A HLA-DRA CD79B Top 200 Genes 3.912E-4 1.654E-2
1.195E-1
3.016E-1
 3 375
17 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-1 (GZMB, LILRA4, PTGDS) Top 200 Genes 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-1 (GZMB, LILRA4, PTGDS) Top 200 Genes 4.004E-4 1.654E-2
1.195E-1
3.087E-1
 3 378
18 10X Human 8K PBMC B cells Subtype B cells-GZMB, LILRA4, PTGDS Top 200 Genes 10X Human 8K PBMC B cells Subtype B cells-GZMB, LILRA4, PTGDS Top 200 Genes 4.035E-4 1.654E-2
1.195E-1
3.111E-1
 3 379
19 10X Human 8K PBMC Dendritic Subtype Dendritic-LILRA4, LRRC26, IL3RA Top 200 Genes 10X Human 8K PBMC Dendritic Subtype Dendritic-LILRA4, LRRC26, IL3RA Top 200 Genes 4.161E-4 1.654E-2
1.195E-1
3.209E-1
 3 383
20 10X Human 8K PBMC Dendritic Subtype Dendritic-CPVL IRF8 LYZ B Top 200 Genes 10X Human 8K PBMC Dendritic Subtype Dendritic-CPVL IRF8 LYZ B Top 200 Genes 4.290E-4 1.654E-2
1.195E-1
3.308E-1
 3 387
21 GSM854299 500 Plasmacytoid, DC.pDC.8+.SLN, B220-FITC CD45-APC CD11c-eFluor780 GR1-PE CD8-eFlu, Lymph Node, avg-3 Immgen.org, GSE15907 5.262E-4 1.883E-2
1.361E-1
4.057E-1
 3 415
22 Lung Development Lungmap - Mouse FluidigmC1 Immune Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Immune Overall Top 500 Genes 5.374E-4 1.883E-2
1.361E-1
4.143E-1
 3 418
23 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/5/1 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/5/1 TCGA-Testes 9.502E-4 3.185E-2
2.302E-1
7.326E-1
 2 114
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell 2/Kidney NephrogenicRest Wilms NK cell 2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell 2/Kidney NephrogenicRest Wilms NK cell 2 Adult, Development, and Cancer types 1.214E-3 3.900E-2
2.818E-1
9.361E-1
 2 129
25 gudmap kidney adult CortVasc Tie2 k4 1000 kidney adult CortVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.387E-3 4.114E-2
2.973E-1
1.000E0
 2 138
26 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Cervical Squamous Cell Carcinoma/4/1 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Cervical Squamous Cell Carcinoma/4/1 TCGA-Cervix 1.387E-3 4.114E-2
2.973E-1
1.000E0
 2 138
27 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/7 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/7 TCGA-Breast 1.530E-3 4.369E-2
3.157E-1
1.000E0
 2 145
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R21 Adult, Development, and Cancer types 1.813E-3 4.991E-2
3.606E-1
1.000E0
 2 158
Show 23 more annotations

15: Computational [Display Chart] 9 input genes in category / 62 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7315 MODULE 119 Genes in the cancer module 119. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.280E-4 1.414E-2
6.663E-2
 1.414E-2 3 144

16: MicroRNA [Display Chart] 10 input genes in category / 254 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 6.095E-4 3.925E-2
2.401E-1
1.548E-1
 2 269
2 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 7.269E-4 3.925E-2
2.401E-1
1.846E-1
 2 294
3 hsa-miR-125a-3p:Functional MTI Functional MTI miRTarbase 8.074E-4 3.925E-2
2.401E-1
2.051E-1
 2 310
4 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 1.310E-3 3.925E-2
2.401E-1
3.328E-1
 2 396
5 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 1.310E-3 3.925E-2
2.401E-1
3.328E-1
 2 396
6 hsa-miR-4323:mirSVR highEffct hsa-miR-4323:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.437E-3 3.925E-2
2.401E-1
3.650E-1
 2 415
7 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 1.534E-3 3.925E-2
2.401E-1
3.897E-1
 2 429
8 hsa-miR-4316:mirSVR highEffct hsa-miR-4316:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.555E-3 3.925E-2
2.401E-1
3.951E-1
 2 432
9 hsa-miR-302d-3p:Functional MTI Functional MTI miRTarbase 1.760E-3 3.925E-2
2.401E-1
4.471E-1
 2 460
10 hsa-miR-770-5p:mirSVR highEffct hsa-miR-770-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.813E-3 3.925E-2
2.401E-1
4.605E-1
 2 467
11 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 1.914E-3 3.925E-2
2.401E-1
4.861E-1
 2 480
12 hsa-miR-302c-3p.2:TargetScan hsa-miR-302c-3p.2 TargetScan 2.009E-3 3.925E-2
2.401E-1
5.103E-1
 2 492
13 hsa-miR-520f-3p:TargetScan hsa-miR-520f-3p TargetScan 2.009E-3 3.925E-2
2.401E-1
5.103E-1
 2 492
Show 8 more annotations

17: Drug [Display Chart] 10 input genes in category / 2946 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005288597 AC1NRBRB Stitch 3.546E-21 1.045E-17 8.948E-17 1.045E-17 8 43
2 CID000159603 resiquimod Stitch 1.438E-17 2.119E-14 1.815E-13 4.237E-14 8 115
3 CID000057697 pemirolast Stitch 7.682E-16 7.543E-13 6.461E-12 2.263E-12 7 83
4 CID000042963 HIDA Stitch 9.920E-15 7.306E-12 6.258E-11 2.923E-11 6 46
5 CID011979623 ridostin Stitch 3.110E-12 1.832E-9 1.569E-8 9.161E-9 6 116
6 CID000107918 oligoadenylate Stitch 1.967E-11 9.657E-9 8.272E-8 5.794E-8 6 157
7 CID000032744 polyinosinic-polycytidylic acid Stitch 8.173E-10 3.440E-7 2.946E-6 2.408E-6 6 291
8 CID000003447 gabexate mesilate Stitch 9.874E-10 3.636E-7 3.114E-6 2.909E-6 5 122
9 CID005288092 peptidomimetic inhibitor Stitch 9.451E-9 3.094E-6 2.650E-5 2.784E-5 5 191
10 ctd:C008435 methyldithiocarbamate CTD 3.687E-8 1.086E-5 9.304E-5 1.086E-4 4 85
11 CID005351568 imidazoquinoline Stitch 7.409E-8 1.984E-5 1.700E-4 2.183E-4 4 101
12 ctd:C540383 INCB018424 CTD 3.274E-7 8.028E-5 6.877E-4 9.646E-4 3 33
13 CID000004261 MS-275 Stitch 3.543E-7 8.028E-5 6.877E-4 1.044E-3 4 149
14 CID000213546 poly(I-C Stitch 6.149E-7 1.294E-4 1.108E-3 1.812E-3 4 171
15 5306 UP Propofol [2078-54-8]; Up 200; 22.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.549E-7 1.483E-4 1.270E-3 2.224E-3 4 180
16 CID000123964 ASA404 Stitch 1.399E-6 2.577E-4 2.207E-3 4.123E-3 3 53
17 CID000454710 Lps2 Stitch 1.841E-6 3.165E-4 2.711E-3 5.424E-3 3 58
18 CID000446871 AC1L9K70 Stitch 1.937E-6 3.165E-4 2.711E-3 5.707E-3 4 228
19 CID000060737 loxoribine Stitch 2.041E-6 3.165E-4 2.711E-3 6.013E-3 3 60
20 CID000000797 poly I Stitch 2.839E-6 4.181E-4 3.582E-3 8.363E-3 4 251
21 CID000002245 doyle Stitch 6.503E-6 9.122E-4 7.814E-3 1.916E-2 3 88
22 CID000003154 Cosopt Stitch 9.548E-6 1.279E-3 1.095E-2 2.813E-2 4 341
23 CID000409844 5H-purin-2-amine Stitch 1.014E-5 1.299E-3 1.113E-2 2.988E-2 3 102
24 CID000092807 AC1Q6A7C Stitch 1.136E-5 1.394E-3 1.194E-2 3.347E-2 2 12
25 CID000024141 NPRO Stitch 1.566E-5 1.774E-3 1.519E-2 4.612E-2 2 14
26 ctd:C518299 BIX 01294 CTD 1.566E-5 1.774E-3 1.519E-2 4.612E-2 2 14
27 CID000057469 imiquimod Stitch 2.198E-5 2.398E-3 2.054E-2
6.475E-2
 3 132
28 CID000071618 Nyco Stitch 2.630E-5 2.767E-3 2.370E-2
7.747E-2
 2 18
29 CID000015979 pristane Stitch 3.350E-5 3.404E-3 2.915E-2
9.870E-2
 3 152
30 CID004369451 T1 d Stitch 3.905E-5 3.662E-3 3.137E-2
1.150E-1
 3 160
31 CID000344265 DNA methyltransferase inhibitor Stitch 3.905E-5 3.662E-3 3.137E-2
1.150E-1
 3 160
32 1297 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Up 3.978E-5 3.662E-3 3.137E-2
1.172E-1
 3 161
33 CID004444603 HMPV Stitch 5.148E-5 4.460E-3 3.821E-2
1.517E-1
 2 25
34 ctd:D003606 Dacarbazine CTD 5.148E-5 4.460E-3 3.821E-2
1.517E-1
 2 25
35 6205 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.731E-5 4.824E-3 4.132E-2
1.688E-1
 3 182
36 5019 UP Dehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.311E-5 4.892E-3 4.190E-2
1.859E-1
 3 188
37 2627 UP Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.615E-5 4.892E-3 4.190E-2
1.949E-1
 3 191
38 4367 UP (1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.615E-5 4.892E-3 4.190E-2
1.949E-1
 3 191
39 4410 DN Captopril [62571-86-2]; Down 200; 17.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 6.823E-5 4.892E-3 4.190E-2
2.010E-1
 3 193
40 6325 DN Molsidomine [25717-80-0]; Down 200; 16.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.252E-5 4.892E-3 4.190E-2
2.136E-1
 3 197
41 7505 DN 16-phenyl tetranor Prostaglandin E2; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.362E-5 4.892E-3 4.190E-2
2.169E-1
 3 198
42 3235 UP Chlormezanone [80-77-3]; Up 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.362E-5 4.892E-3 4.190E-2
2.169E-1
 3 198
43 6296 UP Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.362E-5 4.892E-3 4.190E-2
2.169E-1
 3 198
44 CID011979660 poly rI:rC Stitch 7.456E-5 4.892E-3 4.190E-2
2.196E-1
 2 30
45 5449 UP Tubocurarine chloride pentahydrate (+) [6989-98-6]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.473E-5 4.892E-3 4.190E-2
2.201E-1
 3 199
46 ctd:C510788 N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine CTD 8.497E-5 5.442E-3 4.661E-2
2.503E-1
 2 32
47 CID000428410 NSC237521 Stitch 8.891E-5 5.573E-3 4.773E-2
2.619E-1
 3 211
48 CID004631220 AC1NDT8D Stitch 9.606E-5 5.896E-3
5.050E-2
2.830E-1
 2 34
49 CID000005475 tilorone Stitch 1.019E-4 6.124E-3
5.246E-2
3.001E-1
 2 35
50 CID000125053 S-TDCM Stitch 1.472E-4 8.670E-3
7.427E-2
4.335E-1
 2 42
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 447 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0036220 Kaposi Sarcoma DisGeNET Curated 7.082E-7 1.844E-4 1.232E-3 3.166E-4 5 323
2 C0266999 Vesicular Stomatitis DisGeNET Curated 8.249E-7 1.844E-4 1.232E-3 3.687E-4 4 131
3 C0524910 Hepatitis C, Chronic DisGeNET Curated 1.331E-6 1.983E-4 1.325E-3 5.948E-4 5 367
4 C0024266 Lymphocytic Choriomeningitis DisGeNET BeFree 3.470E-6 3.102E-4 2.072E-3 1.551E-3 3 51
5 C0153014 Non-arthropod borne lymphocytic choriomeningitis DisGeNET BeFree 3.470E-6 3.102E-4 2.072E-3 1.551E-3 3 51
6 C0862030 B Lymphoblastic Leukemia/Lymphoma DisGeNET BeFree 5.134E-6 3.768E-4 2.517E-3 2.295E-3 2 6
7 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 5.900E-6 3.768E-4 2.517E-3 2.637E-3 5 497
8 C0023474 Leukemia, Myeloid, Chronic-Phase DisGeNET BeFree 1.029E-5 5.634E-4 3.764E-3 4.599E-3 3 73
9 C1402315 Vascular lesions DisGeNET BeFree 1.256E-5 5.634E-4 3.764E-3 5.616E-3 3 78
10 C0007113 Rectal Carcinoma DisGeNET BeFree 1.260E-5 5.634E-4 3.764E-3 5.634E-3 4 260
11 C1096184 West Nile viral infection DisGeNET BeFree 1.408E-5 5.721E-4 3.822E-3 6.293E-3 3 81
12 C1319860 Sendai virus infection DisGeNET BeFree 1.880E-5 7.001E-4 4.677E-3 8.401E-3 2 11
13 C0035112 Reoviridae Infections DisGeNET BeFree 3.583E-5 1.232E-3 8.232E-3 1.602E-2 2 15
14 C1861453 Pseudohyperkalemia Cardiff DisGeNET Curated 5.547E-5 1.771E-3 1.183E-2 2.480E-2 3 128
15 C0035613 Rift Valley Fever DisGeNET BeFree 6.474E-5 1.929E-3 1.289E-2 2.894E-2 2 20
16 C1292753 Primary Effusion Lymphoma DisGeNET BeFree 9.618E-5 2.577E-3 1.722E-2 4.299E-2 3 154
17 C0276138 Viral myocarditis DisGeNET BeFree 1.020E-4 2.577E-3 1.722E-2 4.562E-2 2 25
18 C1306759 Eosinophilic disorder DisGeNET BeFree 1.038E-4 2.577E-3 1.722E-2 4.639E-2 3 158
19 C0014457 Eosinophilia DisGeNET Curated 1.478E-4 3.476E-3 2.322E-2
6.604E-2
 3 178
20 C0376544 Hematopoietic Neoplasms DisGeNET BeFree 1.764E-4 3.943E-3 2.634E-2
7.886E-2
 3 189
21 C0155877 Allergic asthma DisGeNET BeFree 1.994E-4 4.244E-3 2.835E-2
8.913E-2
 3 197
22 C1298180 Single tumor DisGeNET BeFree 3.651E-4 6.896E-3 4.607E-2
1.632E-1
 2 47
23 C0030499 Parasitic Diseases DisGeNET BeFree 4.133E-4 6.896E-3 4.607E-2
1.847E-1
 2 50
24 C4016741 IMMUNODEFICIENCY 32B DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
25 cv:C0175697 Van der Woude syndrome Clinical Variations 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
26 C4225294 HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 7 DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
27 OMIN:119500 POPLITEAL PTERYGIUM SYNDROME; PPS OMIM 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
28 C1837213 OROFACIAL CLEFT 6, SUSCEPTIBILITY TO DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
29 cv:C1837213 Orofacial cleft 6, susceptibility to Clinical Variations 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
30 C4024212 Pyramidal skinfold extending from the base to the top of the nails DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
31 C4225358 IMMUNODEFICIENCY 39 DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
32 cv:C0265259 Popliteal pterygium syndrome Clinical Variations 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
33 OMIN:119300 VAN DER WOUDE SYNDROME; VWS OMIM 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
34 C4021392 Fibrous syngnathia DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
35 cv:CN178080 Autosomal dominant CD11C+/CD1C+ dendritic cell deficiency Clinical Variations 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
36 C0037650 Somatoform Disorder DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
37 cv:C2673265 Skin/hair/eye pigmentation, variation in, 8 Clinical Variations 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
38 OMIN:608864 OROFACIAL CLEFT 6, SUSCEPTIBILITY TO; OFC6 OMIM 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
39 C3808589 IMMUNODEFICIENCY 32A DisGeNET Curated 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
40 cv:CN178081 Monocyte and dendritic cell deficiency, autosomal recessive Clinical Variations 6.171E-4 6.896E-3 4.607E-2
2.758E-1
 1 1
41 C0040034 Thrombocytopenia DisGeNET Curated 6.845E-4 7.462E-3 4.985E-2
3.060E-1
 3 300
42 C0033999 Pterygium DisGeNET Curated 7.865E-4 8.371E-3
5.593E-2
3.516E-1
 2 69
43 C0282687 Hemorrhagic Fever, Ebola DisGeNET BeFree 8.326E-4 8.655E-3
5.782E-2
3.722E-1
 2 71
44 C0024301 Lymphoma, Follicular DisGeNET Curated 1.062E-3 1.021E-2
6.824E-2
4.747E-1
 3 349
45 C0026918 Mycobacterium Infections DisGeNET Curated 1.219E-3 1.021E-2
6.824E-2
5.447E-1
 2 86
46 C0343537 Specific viral infections DisGeNET BeFree 1.234E-3 1.021E-2
6.824E-2
5.515E-1
 1 2
47 C1861544 Lower lip pits DisGeNET Curated 1.234E-3 1.021E-2
6.824E-2
5.515E-1
 1 2
48 C3810471 Intercrural pterygium DisGeNET Curated 1.234E-3 1.021E-2
6.824E-2
5.515E-1
 1 2
49 C0751378 Neurologic Signs DisGeNET BeFree 1.234E-3 1.021E-2
6.824E-2
5.515E-1
 1 2
50 C0343208 Essential mixed cryoglobulinemia DisGeNET BeFree 1.234E-3 1.021E-2
6.824E-2
5.515E-1
 1 2
Show 45 more annotations