Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc99_29, positive side

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1: GO: Molecular Function [Display Chart] 29 input genes in category / 161 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003684 damaged DNA binding 5.619E-14 9.046E-12 5.122E-11 9.046E-12 8 65
2 GO:0042162 telomeric DNA binding 1.041E-9 8.381E-8 4.745E-7 1.676E-7 5 31
3 GO:0008094 DNA-dependent ATPase activity 5.635E-9 3.024E-7 1.712E-6 9.072E-7 6 93
4 GO:0004003 ATP-dependent DNA helicase activity 9.239E-9 3.719E-7 2.105E-6 1.487E-6 5 47
5 GO:0003678 DNA helicase activity 4.880E-8 1.571E-6 8.896E-6 7.856E-6 5 65
6 GO:0003909 DNA ligase activity 1.176E-7 3.156E-6 1.787E-5 1.893E-5 3 7
7 GO:0003691 double-stranded telomeric DNA binding 1.880E-7 4.323E-6 2.448E-5 3.026E-5 3 8
8 GO:0016886 ligase activity, forming phosphoric ester bonds 4.020E-7 8.090E-6 4.580E-5 6.472E-5 3 10
9 GO:0070035 purine NTP-dependent helicase activity 7.535E-7 1.213E-5 6.869E-5 1.213E-4 5 112
10 GO:0008026 ATP-dependent helicase activity 7.535E-7 1.213E-5 6.869E-5 1.213E-4 5 112
11 GO:0004386 helicase activity 6.230E-6 9.119E-5 5.163E-4 1.003E-3 5 172
12 GO:0042623 ATPase activity, coupled 1.019E-5 1.367E-4 7.742E-4 1.641E-3 6 332
13 GO:0003697 single-stranded DNA binding 1.942E-5 2.405E-4 1.362E-3 3.127E-3 4 104
14 GO:0008022 protein C-terminus binding 2.237E-5 2.496E-4 1.413E-3 3.602E-3 5 224
15 GO:0051575 5'-deoxyribose-5-phosphate lyase activity 2.325E-5 2.496E-4 1.413E-3 3.744E-3 2 5
16 GO:0003910 DNA ligase (ATP) activity 3.484E-5 3.401E-4 1.926E-3 5.610E-3 2 6
17 GO:0016874 ligase activity 3.591E-5 3.401E-4 1.926E-3 5.782E-3 6 415
18 GO:0016887 ATPase activity 5.366E-5 4.800E-4 2.718E-3 8.640E-3 6 446
19 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 6.492E-5 5.501E-4 3.114E-3 1.045E-2 2 8
20 GO:0043047 single-stranded telomeric DNA binding 1.041E-4 8.382E-4 4.746E-3 1.676E-2 2 10
21 GO:0098847 sequence-specific single stranded DNA binding 1.524E-4 1.169E-3 6.616E-3 2.454E-2 2 12
22 GO:0004527 exonuclease activity 2.752E-4 2.014E-3 1.140E-2 4.430E-2 3 82
23 GO:0035258 steroid hormone receptor binding 3.503E-4 2.452E-3 1.388E-2
5.640E-2
 3 89
24 GO:0004536 deoxyribonuclease activity 6.342E-4 4.254E-3 2.409E-2
1.021E-1
 3 109
25 GO:0042826 histone deacetylase binding 7.226E-4 4.586E-3 2.596E-2
1.163E-1
 3 114
26 GO:0003950 NAD+ ADP-ribosyltransferase activity 7.405E-4 4.586E-3 2.596E-2
1.192E-1
 2 26
27 GO:0047485 protein N-terminus binding 7.793E-4 4.647E-3 2.631E-2
1.255E-1
 3 117
28 GO:0097162 MADS box domain binding 1.554E-3 7.582E-3 4.293E-2
2.502E-1
 1 1
29 GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity 1.554E-3 7.582E-3 4.293E-2
2.502E-1
 1 1
30 GO:0035730 S-nitrosoglutathione binding 1.554E-3 7.582E-3 4.293E-2
2.502E-1
 1 1
31 GO:1990404 protein ADP-ribosylase activity 1.554E-3 7.582E-3 4.293E-2
2.502E-1
 1 1
32 GO:0070975 FHA domain binding 1.554E-3 7.582E-3 4.293E-2
2.502E-1
 1 1
33 GO:0035731 dinitrosyl-iron complex binding 1.554E-3 7.582E-3 4.293E-2
2.502E-1
 1 1
34 GO:0035257 nuclear hormone receptor binding 1.953E-3 9.250E-3
5.237E-2
3.145E-1
 3 161
35 GO:0030331 estrogen receptor binding 2.414E-3 1.110E-2
6.287E-2
3.886E-1
 2 47
36 GO:0051427 hormone receptor binding 2.810E-3 1.250E-2
7.078E-2
4.524E-1
 3 183
37 GO:0008408 3'-5' exonuclease activity 2.947E-3 1.250E-2
7.078E-2
4.744E-1
 2 52
38 GO:0008967 phosphoglycolate phosphatase activity 3.106E-3 1.250E-2
7.078E-2
5.000E-1
 1 2
39 GO:0046403 polynucleotide 3'-phosphatase activity 3.106E-3 1.250E-2
7.078E-2
5.000E-1
 1 2
40 GO:0035402 histone kinase activity (H3-T11 specific) 3.106E-3 1.250E-2
7.078E-2
5.000E-1
 1 2
41 GO:0016763 transferase activity, transferring pentosyl groups 3.409E-3 1.339E-2
7.579E-2
5.489E-1
 2 56
42 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor 4.655E-3 1.595E-2
9.028E-2
7.495E-1
 1 3
43 GO:0070026 nitric oxide binding 4.655E-3 1.595E-2
9.028E-2
7.495E-1
 1 3
44 GO:0004882 androgen receptor activity 4.655E-3 1.595E-2
9.028E-2
7.495E-1
 1 3
45 GO:0061731 ribonucleoside-diphosphate reductase activity 4.655E-3 1.595E-2
9.028E-2
7.495E-1
 1 3
46 GO:0010484 H3 histone acetyltransferase activity 4.655E-3 1.595E-2
9.028E-2
7.495E-1
 1 3
47 GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 4.655E-3 1.595E-2
9.028E-2
7.495E-1
 1 3
48 GO:0004518 nuclease activity 5.331E-3 1.752E-2
9.918E-2
8.582E-1
 3 230
49 GO:0018169 ribosomal S6-glutamic acid ligase activity 6.136E-3 1.752E-2
9.918E-2
9.880E-1
 3 242
50 GO:0070735 protein-glycine ligase activity 6.136E-3 1.752E-2
9.918E-2
9.880E-1
 3 242
Show 45 more annotations

2: GO: Biological Process [Display Chart] 29 input genes in category / 1023 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006302 double-strand break repair 3.542E-29 3.623E-26 2.721E-25 3.623E-26 18 196
2 GO:0006310 DNA recombination 1.166E-22 5.963E-20 4.477E-19 1.193E-19 16 267
3 GO:0006303 double-strand break repair via nonhomologous end joining 2.568E-20 8.756E-18 6.574E-17 2.627E-17 11 69
4 GO:0000726 non-recombinational repair 8.013E-20 2.049E-17 1.539E-16 8.197E-17 11 76
5 GO:0000724 double-strand break repair via homologous recombination 1.086E-16 2.070E-14 1.554E-13 1.111E-13 10 93
6 GO:0000725 recombinational repair 1.214E-16 2.070E-14 1.554E-13 1.242E-13 10 94
7 GO:0000723 telomere maintenance 7.381E-15 1.079E-12 8.099E-12 7.550E-12 10 140
8 GO:0032200 telomere organization 1.823E-14 2.332E-12 1.751E-11 1.865E-11 10 153
9 GO:0006260 DNA replication 5.469E-14 6.217E-12 4.668E-11 5.595E-11 12 346
10 GO:0000732 strand displacement 1.849E-12 1.892E-10 1.421E-9 1.892E-9 6 26
11 GO:0051053 negative regulation of DNA metabolic process 6.363E-12 5.918E-10 4.443E-9 6.510E-9 8 115
12 GO:0060249 anatomical structure homeostasis 1.010E-11 8.612E-10 6.466E-9 1.033E-8 11 402
13 GO:0000731 DNA synthesis involved in DNA repair 1.875E-11 1.406E-9 1.056E-8 1.918E-8 7 75
14 GO:0032508 DNA duplex unwinding 2.063E-11 1.406E-9 1.056E-8 2.111E-8 7 76
15 GO:0071897 DNA biosynthetic process 2.134E-11 1.406E-9 1.056E-8 2.183E-8 9 211
16 GO:0006261 DNA-dependent DNA replication 2.199E-11 1.406E-9 1.056E-8 2.250E-8 8 134
17 GO:0032392 DNA geometric change 3.265E-11 1.965E-9 1.475E-8 3.340E-8 7 81
18 GO:0006266 DNA ligation 7.291E-11 4.144E-9 3.111E-8 7.459E-8 5 19
19 GO:0031570 DNA integrity checkpoint 1.117E-10 5.896E-9 4.427E-8 1.143E-7 8 164
20 GO:0051052 regulation of DNA metabolic process 1.153E-10 5.896E-9 4.427E-8 1.179E-7 10 368
21 GO:0000729 DNA double-strand break processing 1.273E-10 6.008E-9 4.511E-8 1.302E-7 5 21
22 GO:1901796 regulation of signal transduction by p53 class mediator 1.292E-10 6.008E-9 4.511E-8 1.322E-7 8 167
23 GO:0072331 signal transduction by p53 class mediator 1.525E-10 6.783E-9 5.093E-8 1.560E-7 9 263
24 GO:0032205 negative regulation of telomere maintenance 4.094E-10 1.745E-8 1.310E-7 4.188E-7 5 26
25 GO:0033044 regulation of chromosome organization 5.039E-10 2.062E-8 1.548E-7 5.155E-7 9 301
26 GO:0032204 regulation of telomere maintenance 8.410E-10 3.309E-8 2.484E-7 8.603E-7 6 68
27 GO:0022616 DNA strand elongation 1.052E-9 3.985E-8 2.992E-7 1.076E-6 5 31
28 GO:0000075 cell cycle checkpoint 1.885E-9 6.886E-8 5.170E-7 1.928E-6 8 234
29 GO:0000077 DNA damage checkpoint 3.089E-9 1.090E-7 8.182E-7 3.160E-6 7 154
30 GO:0032785 negative regulation of DNA-templated transcription, elongation 3.357E-9 1.145E-7 8.595E-7 3.434E-6 4 13
31 GO:0010212 response to ionizing radiation 3.534E-9 1.166E-7 8.757E-7 3.616E-6 7 157
32 GO:0006284 base-excision repair 6.629E-9 2.119E-7 1.591E-6 6.781E-6 5 44
33 GO:0006312 mitotic recombination 7.449E-9 2.309E-7 1.734E-6 7.621E-6 5 45
34 GO:0018205 peptidyl-lysine modification 1.052E-8 3.166E-7 2.377E-6 1.077E-5 9 426
35 GO:0016233 telomere capping 1.285E-8 3.756E-7 2.820E-6 1.315E-5 5 50
36 GO:0031860 telomeric 3' overhang formation 1.357E-8 3.855E-7 2.894E-6 1.388E-5 3 4
37 GO:2001251 negative regulation of chromosome organization 2.281E-8 6.307E-7 4.736E-6 2.334E-5 6 117
38 GO:0045786 negative regulation of cell cycle 3.168E-8 8.527E-7 6.403E-6 3.240E-5 9 484
39 GO:0045930 negative regulation of mitotic cell cycle 4.261E-8 1.118E-6 8.393E-6 4.359E-5 7 225
40 GO:0016925 protein sumoylation 6.678E-8 1.708E-6 1.282E-5 6.831E-5 6 140
41 GO:2001020 regulation of response to DNA damage stimulus 1.271E-7 3.171E-6 2.381E-5 1.300E-4 6 156
42 GO:0006282 regulation of DNA repair 1.325E-7 3.227E-6 2.423E-5 1.355E-4 5 79
43 GO:0010165 response to X-ray 1.880E-7 4.473E-6 3.359E-5 1.924E-4 4 33
44 GO:0071103 DNA conformation change 2.137E-7 4.967E-6 3.730E-5 2.186E-4 7 285
45 GO:1903900 regulation of viral life cycle 2.594E-7 5.898E-6 4.428E-5 2.654E-4 6 176
46 GO:0071481 cellular response to X-ray 2.834E-7 6.302E-6 4.732E-5 2.899E-4 3 9
47 GO:0097193 intrinsic apoptotic signaling pathway 3.092E-7 6.730E-6 5.053E-5 3.163E-4 7 301
48 GO:0031572 G2 DNA damage checkpoint 3.374E-7 7.190E-6 5.399E-5 3.451E-4 4 38
49 GO:0050792 regulation of viral process 3.948E-7 8.242E-6 6.188E-5 4.038E-4 6 189
50 GO:0000012 single strand break repair 4.044E-7 8.275E-6 6.213E-5 4.137E-4 3 10
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 29 input genes in category / 66 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000781 chromosome, telomeric region 4.465E-20 2.947E-18 1.407E-17 2.947E-18 13 162
2 GO:0000784 nuclear chromosome, telomeric region 3.895E-17 1.285E-15 6.137E-15 2.571E-15 11 133
3 GO:0098687 chromosomal region 8.997E-16 1.979E-14 9.450E-14 5.938E-14 13 344
4 GO:0030870 Mre11 complex 6.466E-11 1.067E-9 5.094E-9 4.267E-9 4 6
5 GO:0035861 site of double-strand break 1.715E-7 2.263E-6 1.081E-5 1.132E-5 4 33
6 GO:0070419 nonhomologous end joining complex 2.643E-7 2.908E-6 1.388E-5 1.745E-5 3 9
7 GO:0000794 condensed nuclear chromosome 3.315E-7 3.126E-6 1.492E-5 2.188E-5 5 97
8 GO:0000793 condensed chromosome 6.052E-7 4.946E-6 2.362E-5 3.995E-5 6 208
9 GO:1990391 DNA repair complex 6.745E-7 4.946E-6 2.362E-5 4.452E-5 4 46
10 GO:0000782 telomere cap complex 8.963E-7 5.378E-6 2.568E-5 5.916E-5 3 13
11 GO:0000783 nuclear telomere cap complex 8.963E-7 5.378E-6 2.568E-5 5.916E-5 3 13
12 GO:0031436 BRCA1-BARD1 complex 2.235E-6 1.229E-5 5.869E-5 1.475E-4 2 2
13 GO:0005657 replication fork 3.099E-6 1.573E-5 7.512E-5 2.045E-4 4 67
14 GO:0043564 Ku70:Ku80 complex 6.699E-6 3.158E-5 1.508E-4 4.421E-4 2 3
15 GO:0032021 NELF complex 1.338E-5 5.889E-5 2.812E-4 8.834E-4 2 4
16 GO:0070531 BRCA1-A complex 4.671E-5 1.927E-4 9.200E-4 3.083E-3 2 7
17 GO:0008023 transcription elongation factor complex 5.915E-5 2.296E-4 1.096E-3 3.904E-3 3 50
18 GO:0032993 protein-DNA complex 1.618E-4 5.934E-4 2.833E-3 1.068E-2 4 183
19 GO:0016605 PML body 4.502E-4 1.564E-3 7.467E-3 2.971E-2 3 99
20 GO:0000785 chromatin 7.627E-4 2.517E-3 1.202E-2
5.034E-2
 5 487
21 GO:0033593 BRCA2-MAGE-D1 complex 1.521E-3 4.782E-3 2.283E-2
1.004E-1
 1 1
22 GO:0000152 nuclear ubiquitin ligase complex 1.853E-3 5.559E-3 2.654E-2
1.223E-1
 2 42
23 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) 3.041E-3 8.027E-3 3.833E-2
2.007E-1
 1 2
24 GO:0032044 DSIF complex 3.041E-3 8.027E-3 3.833E-2
2.007E-1
 1 2
25 GO:0097057 TRAF2-GSTP1 complex 3.041E-3 8.027E-3 3.833E-2
2.007E-1
 1 2
26 GO:0005971 ribonucleoside-diphosphate reductase complex 4.558E-3 1.157E-2
5.524E-2
3.008E-1
 1 3
27 GO:0016234 inclusion body 5.641E-3 1.379E-2
6.583E-2
3.723E-1
 2 74
28 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex 6.072E-3 1.431E-2
6.834E-2
4.008E-1
 1 4
29 GO:0000151 ubiquitin ligase complex 8.144E-3 1.854E-2
8.850E-2
5.375E-1
 3 274
30 GO:0070187 shelterin complex 1.060E-2 2.333E-2
1.114E-1
6.998E-1
 1 7
31 GO:0000931 gamma-tubulin large complex 1.211E-2 2.497E-2
1.192E-1
7.992E-1
 1 8
32 GO:0008274 gamma-tubulin ring complex 1.211E-2 2.497E-2
1.192E-1
7.992E-1
 1 8
33 GO:0000790 nuclear chromatin 1.282E-2 2.564E-2
1.224E-1
8.463E-1
 3 324
34 GO:0016604 nuclear body 1.748E-2 3.320E-2
1.585E-1
1.000E0
 3 364
35 GO:0005667 transcription factor complex 1.799E-2 3.320E-2
1.585E-1
1.000E0
 3 368
36 GO:0042405 nuclear inclusion body 1.811E-2 3.320E-2
1.585E-1
1.000E0
 1 12
37 GO:0044450 microtubule organizing center part 2.093E-2 3.664E-2
1.750E-1
1.000E0
 2 147
38 GO:0000800 lateral element 2.110E-2 3.664E-2
1.750E-1
1.000E0
 1 14
39 GO:0005662 DNA replication factor A complex 2.408E-2 4.074E-2
1.945E-1
1.000E0
 1 16
40 GO:0000930 gamma-tubulin complex 3.001E-2 4.948E-2
2.362E-1
1.000E0
 1 20
41 GO:0001673 male germ cell nucleus 3.148E-2 4.948E-2
2.362E-1
1.000E0
 1 21
42 GO:0045120 pronucleus 3.148E-2 4.948E-2
2.362E-1
1.000E0
 1 21
Show 37 more annotations

4: Human Phenotype [Display Chart] 11 input genes in category / 1049 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0040012 Chromosome breakage 3.786E-8 2.821E-5 2.125E-4 3.971E-5 4 17
2 HP:0003220 Abnormality of chromosome stability 5.378E-8 2.821E-5 2.125E-4 5.641E-5 5 51
3 HP:0030358 Non-small cell lung carcinoma 3.308E-7 8.675E-5 6.535E-4 3.470E-4 3 7
4 HP:0030078 Lung adenocarcinoma 3.308E-7 8.675E-5 6.535E-4 3.470E-4 3 7
5 HP:0012125 Prostate cancer 4.922E-7 8.753E-5 6.594E-4 5.163E-4 4 31
6 HP:0002916 Abnormality of chromosome segregation 5.007E-7 8.753E-5 6.594E-4 5.252E-4 5 79
7 HP:0030406 Primary peritoneal carcinoma 1.130E-6 1.693E-4 1.275E-3 1.185E-3 3 10
8 HP:0008711 Benign prostatic hyperplasia 1.551E-6 2.034E-4 1.532E-3 1.627E-3 3 11
9 HP:0000017 Nocturia 2.682E-6 3.126E-4 2.355E-3 2.814E-3 3 13
10 HP:0007716 Uveal melanoma 3.409E-6 3.576E-4 2.694E-3 3.576E-3 3 14
11 HP:0003148 Elevated serum acid phosphatase 6.345E-6 6.051E-4 4.558E-3 6.656E-3 3 17
12 HP:0012056 Cutaneous melanoma 1.060E-5 9.263E-4 6.978E-3 1.112E-2 3 20
13 HP:0004356 Abnormality of lysosomal metabolism 1.235E-5 9.963E-4 7.505E-3 1.295E-2 3 21
14 HP:0010997 Chromosomal breakage induced by ionizing radiation 1.488E-5 1.115E-3 8.398E-3 1.561E-2 2 3
15 HP:0011027 Abnormality of the fallopian tube 1.872E-5 1.309E-3 9.861E-3 1.963E-2 3 24
16 HP:0100518 Dysuria 2.398E-5 1.572E-3 1.184E-2 2.516E-2 3 26
17 HP:0100787 Prostate neoplasm 3.407E-5 2.102E-3 1.584E-2 3.573E-2 4 88
18 HP:0000957 Cafe-au-lait spot 5.214E-5 3.038E-3 2.289E-2
5.469E-2
 4 98
19 HP:0002573 Hematochezia 6.502E-5 3.497E-3 2.634E-2
6.821E-2
 3 36
20 HP:0003002 Breast carcinoma 6.845E-5 3.497E-3 2.634E-2
7.180E-2
 5 214
21 HP:0010623 Tumours of the breast 7.000E-5 3.497E-3 2.634E-2
7.343E-2
 5 215
22 HP:0100013 Neoplasm of the breast 7.990E-5 3.810E-3 2.870E-2
8.382E-2
 5 221
23 HP:0005521 Disseminated intravascular coagulation 1.114E-4 4.868E-3 3.667E-2
1.168E-1
 3 43
24 HP:0000016 Urinary retention 1.114E-4 4.868E-3 3.667E-2
1.168E-1
 3 43
25 HP:0100590 Rectal fistula 1.277E-4 5.360E-3 4.038E-2
1.340E-1
 3 45
26 HP:0100819 Intestinal fistula 1.456E-4 5.874E-3 4.425E-2
1.527E-1
 3 47
27 HP:0008775 Abnormality of the prostate 1.625E-4 6.088E-3 4.586E-2
1.705E-1
 4 131
28 HP:0002894 Neoplasm of the pancreas 1.625E-4 6.088E-3 4.586E-2
1.705E-1
 4 131
29 HP:0100615 Ovarian neoplasm 2.045E-4 7.299E-3
5.498E-2
2.146E-1
 4 139
30 HP:0006000 Ureteral obstruction 2.087E-4 7.299E-3
5.498E-2
2.190E-1
 3 53
31 HP:0003221 Chromosomal breakage induced by crosslinking agents 2.212E-4 7.485E-3
5.639E-2
2.320E-1
 2 10
32 HP:0006740 Transitional cell carcinoma of the bladder 2.332E-4 7.644E-3
5.758E-2
2.446E-1
 3 55
33 HP:0025085 Bloody diarrhea 2.594E-4 8.092E-3
6.096E-2
2.721E-1
 3 57
34 HP:0000137 Abnormality of the ovary 2.683E-4 8.092E-3
6.096E-2
2.814E-1
 5 285
35 HP:0000571 Hypometric saccades 2.700E-4 8.092E-3
6.096E-2
2.832E-1
 2 11
36 HP:0010614 Fibroma 2.819E-4 8.213E-3
6.187E-2
2.957E-1
 5 288
37 HP:0012316 Fibrous tissue neoplasm 2.912E-4 8.256E-3
6.219E-2
3.055E-1
 5 290
38 HP:0001034 Hypermelanotic macule 3.355E-4 9.260E-3
6.976E-2
3.519E-1
 4 158
39 HP:0100526 Neoplasm of the lung 3.521E-4 9.470E-3
7.134E-2
3.693E-1
 4 160
40 HP:0002607 Bowel incontinence 3.833E-4 1.005E-2
7.572E-2
4.021E-1
 3 65
41 HP:0100606 Neoplasm of the respiratory system 3.962E-4 1.013E-2
7.630E-2
4.157E-1
 4 165
42 HP:0004430 Severe combined immunodeficiency 4.055E-4 1.013E-2
7.630E-2
4.254E-1
 4 166
43 HP:0012700 Abnormal large intestine physiology 4.772E-4 1.107E-2
8.343E-2
5.006E-1
 3 70
44 HP:0002756 Pathologic fracture 4.772E-4 1.107E-2
8.343E-2
5.006E-1
 3 70
45 HP:0002861 Melanoma 4.856E-4 1.107E-2
8.343E-2
5.094E-1
 4 174
46 HP:0005387 Combined immunodeficiency 4.856E-4 1.107E-2
8.343E-2
5.094E-1
 4 174
47 HP:0012733 Macule 5.411E-4 1.208E-2
9.098E-2
5.676E-1
 4 179
48 HP:0009778 Short thumb 6.082E-4 1.329E-2
1.001E-1
6.380E-1
 3 76
49 HP:0030448 Soft tissue sarcoma 6.831E-4 1.462E-2
1.102E-1
7.166E-1
 5 348
50 HP:0007824 Total ophthalmoplegia 7.444E-4 1.562E-2
1.177E-1
7.809E-1
 2 18
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 27 input genes in category / 1136 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004028 chromosome breakage 5.264E-22 5.979E-19 4.552E-18 5.979E-19 13 72
2 MP:0010094 abnormal chromosome stability 7.223E-21 4.103E-18 3.123E-17 8.205E-18 14 121
3 MP:0008866 chromosomal instability 5.462E-19 2.068E-16 1.575E-15 6.205E-16 13 119
4 MP:0003992 increased mortality induced by ionizing radiation 2.099E-17 5.960E-15 4.538E-14 2.384E-14 10 50
5 MP:0020149 abnormal mortality induced by ionizing radiation 3.966E-17 8.542E-15 6.503E-14 4.505E-14 10 53
6 MP:0004227 increased cellular sensitivity to ionizing radiation 4.512E-17 8.542E-15 6.503E-14 5.125E-14 11 82
7 MP:0012734 abnormal response to radiation 7.210E-17 1.170E-14 8.907E-14 8.190E-14 10 56
8 MP:0008058 abnormal DNA repair 5.619E-15 7.978E-13 6.074E-12 6.383E-12 11 125
9 MP:0008943 increased sensitivity to induced cell death 8.346E-15 1.053E-12 8.020E-12 9.481E-12 12 182
10 MP:0001658 increased mortality induced by gamma-irradiation 1.529E-14 1.737E-12 1.322E-11 1.737E-11 8 35
11 MP:0008942 abnormal induced cell death 4.816E-13 4.973E-11 3.786E-10 5.471E-10 12 255
12 MP:0010288 increased gland tumor incidence 2.311E-12 2.188E-10 1.666E-9 2.625E-9 12 291
13 MP:0002024 increased T cell derived lymphoma incidence 2.950E-12 2.578E-10 1.963E-9 3.352E-9 9 104
14 MP:0010365 increased thymus tumor incidence 3.222E-12 2.614E-10 1.990E-9 3.660E-9 9 105
15 MP:0004045 abnormal cell cycle checkpoint function 3.547E-12 2.686E-10 2.045E-9 4.029E-9 8 66
16 MP:0012431 increased lymphoma incidence 1.500E-11 1.065E-9 8.106E-9 1.704E-8 11 255
17 MP:0002007 increased cellular sensitivity to gamma-irradiation 6.572E-11 4.392E-9 3.343E-8 7.466E-8 7 55
18 MP:0010296 increased hemolymphoid system tumor incidence 1.037E-10 6.542E-9 4.981E-8 1.178E-7 11 305
19 MP:0004030 induced chromosome breakage 4.177E-9 2.497E-7 1.901E-6 4.745E-6 5 25
20 MP:0001883 increased mammary adenocarcinoma incidence 5.748E-9 3.265E-7 2.486E-6 6.530E-6 6 57
21 MP:0004024 aneuploidy 1.417E-8 7.664E-7 5.835E-6 1.609E-5 6 66
22 MP:0004029 spontaneous chromosome breakage 1.563E-8 8.073E-7 6.146E-6 1.776E-5 5 32
23 MP:0002018 increased malignant tumor incidence 2.618E-8 1.293E-6 9.845E-6 2.974E-5 10 393
24 MP:0004023 abnormal chromosome number 8.132E-8 3.849E-6 2.930E-5 9.238E-5 6 88
25 MP:0003077 abnormal cell cycle 9.045E-8 4.110E-6 3.129E-5 1.027E-4 9 332
26 MP:0004816 abnormal class switch recombination 1.134E-7 4.954E-6 3.771E-5 1.288E-4 6 93
27 MP:0020148 abnormal sensitivity to induced morbidity/mortality 1.232E-7 5.183E-6 3.946E-5 1.399E-4 10 463
28 MP:0010293 increased integument system tumor incidence 1.693E-7 6.871E-6 5.231E-5 1.924E-4 7 167
29 MP:0010299 increased mammary gland tumor incidence 1.859E-7 7.282E-6 5.544E-5 2.112E-4 6 101
30 MP:0010948 abnormal double-strand DNA break repair 2.147E-7 8.128E-6 6.188E-5 2.438E-4 5 53
31 MP:0009308 increased adenocarcinoma incidence 2.720E-7 9.968E-6 7.588E-5 3.090E-4 7 179
32 MP:0003111 abnormal cell nucleus morphology 4.538E-7 1.611E-5 1.227E-4 5.156E-4 7 193
33 MP:0002364 abnormal thymus size 8.780E-7 3.022E-5 2.301E-4 9.974E-4 9 434
34 MP:0011092 embryonic lethality, complete penetrance 1.211E-6 4.046E-5 3.080E-4 1.376E-3 9 451
35 MP:0003702 abnormal chromosome morphology 1.714E-6 5.563E-5 4.235E-4 1.947E-3 5 80
36 MP:0001935 decreased litter size 1.785E-6 5.633E-5 4.288E-4 2.028E-3 8 345
37 MP:0002144 abnormal B cell differentiation 1.864E-6 5.723E-5 4.357E-4 2.118E-3 8 347
38 MP:0001933 abnormal litter size 2.211E-6 6.611E-5 5.033E-4 2.512E-3 8 355
39 MP:0008021 increased blastoma incidence 3.835E-6 1.117E-4 8.503E-4 4.356E-3 4 42
40 MP:0002009 preneoplasia 5.646E-6 1.587E-4 1.208E-3 6.414E-3 3 14
41 MP:0002407 abnormal double-negative T cell morphology 5.727E-6 1.587E-4 1.208E-3 6.505E-3 6 181
42 MP:0008209 decreased pre-B cell number 6.899E-6 1.866E-4 1.421E-3 7.837E-3 5 106
43 MP:0009850 embryonic lethality between implantation and placentation 1.217E-5 3.189E-4 2.428E-3 1.383E-2 8 447
44 MP:0002038 increased carcinoma incidence 1.235E-5 3.189E-4 2.428E-3 1.403E-2 7 317
45 MP:0004500 increased incidence of tumors by ionizing radiation induction 1.490E-5 3.761E-4 2.864E-3 1.693E-2 3 19
46 MP:0030927 decreased telomere length 2.038E-5 5.033E-4 3.832E-3 2.315E-2 3 21
47 MP:0002403 abnormal pre-B cell morphology 2.085E-5 5.040E-4 3.837E-3 2.369E-2 5 133
48 MP:0000706 small thymus 3.133E-5 7.414E-4 5.644E-3 3.559E-2 7 366
49 MP:0013554 abnormal apocrine gland morphology 4.118E-5 9.357E-4 7.123E-3 4.679E-2 6 256
50 MP:0000627 abnormal mammary gland morphology 4.118E-5 9.357E-4 7.123E-3 4.679E-2 6 256
Show 45 more annotations

6: Domain [Display Chart] 29 input genes in category / 283 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS50172 BRCT PROSITE 1.752E-17 4.923E-15 3.064E-14 4.959E-15 8 26
2 IPR001357 BRCT dom InterPro 3.479E-17 4.923E-15 3.064E-14 9.845E-15 8 28
3 PF00533 BRCT Pfam 4.838E-16 4.564E-14 2.841E-13 1.369E-13 7 19
4 SM00292 BRCT SMART 1.632E-15 1.155E-13 7.189E-13 4.620E-13 7 22
5 3.40.50.10190 - Gene3D 2.344E-15 1.327E-13 8.258E-13 6.634E-13 7 23
6 PF00498 FHA Pfam 1.415E-7 6.673E-6 4.154E-5 4.004E-5 4 31
7 IPR000253 FHA dom InterPro 2.635E-7 9.320E-6 5.801E-5 7.456E-5 4 36
8 2.60.200.20 - Gene3D 2.635E-7 9.320E-6 5.801E-5 7.456E-5 4 36
9 IPR008984 SMAD FHA domain InterPro 1.190E-6 3.743E-5 2.330E-4 3.369E-4 4 52
10 PF02735 Ku Pfam 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
11 IPR005161 Ku N InterPro 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
12 IPR006164 Ku70/Ku80 beta-barrel dom InterPro 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
13 SM00559 Ku78 SMART 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
14 PF03731 Ku N Pfam 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
15 1.10.1600.10 - Gene3D 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
16 PF03730 Ku C Pfam 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
17 IPR005160 Ku C InterPro 2.314E-6 3.851E-5 2.397E-4 6.547E-4 2 2
18 2.20.140.10 - Gene3D 6.934E-6 9.344E-5 5.816E-4 1.962E-3 2 3
19 PF02877 PARP reg Pfam 6.934E-6 9.344E-5 5.816E-4 1.962E-3 2 3
20 PF05406 WGR Pfam 6.934E-6 9.344E-5 5.816E-4 1.962E-3 2 3
21 SM00773 WGR SMART 6.934E-6 9.344E-5 5.816E-4 1.962E-3 2 3
22 SM00240 FHA SMART 1.064E-5 1.369E-4 8.522E-4 3.012E-3 3 28
23 PS51060 PARP ALPHA HD PROSITE 1.385E-5 1.568E-4 9.762E-4 3.921E-3 2 4
24 IPR004102 Poly(ADP-ribose)pol reg dom InterPro 1.385E-5 1.568E-4 9.762E-4 3.921E-3 2 4
25 1.20.142.10 - Gene3D 1.385E-5 1.568E-4 9.762E-4 3.921E-3 2 4
26 PS50006 FHA DOMAIN PROSITE 1.456E-5 1.585E-4 9.863E-4 4.120E-3 3 31
27 2.40.290.10 - Gene3D 2.307E-5 2.251E-4 1.401E-3 6.528E-3 2 5
28 IPR016194 SPOC-like C dom InterPro 2.307E-5 2.251E-4 1.401E-3 6.528E-3 2 5
29 PF16589 BRCT 2 Pfam 2.307E-5 2.251E-4 1.401E-3 6.528E-3 2 5
30 PF00644 PARP Pfam 3.101E-4 2.660E-3 1.655E-2
8.777E-2
 2 17
31 3.90.228.10 - Gene3D 3.101E-4 2.660E-3 1.655E-2
8.777E-2
 2 17
32 IPR012317 Poly(ADP-ribose)pol cat dom InterPro 3.101E-4 2.660E-3 1.655E-2
8.777E-2
 2 17
33 PS51059 PARP CATALYTIC PROSITE 3.101E-4 2.660E-3 1.655E-2
8.777E-2
 2 17
34 IPR014722 Rib L2 dom2 InterPro 3.486E-4 2.818E-3 1.754E-2
9.864E-2
 2 18
35 2.30.30.30 - Gene3D 3.486E-4 2.818E-3 1.754E-2
9.864E-2
 2 18
36 IPR008893 WGR domain InterPro 6.252E-4 3.877E-3 2.413E-2
1.769E-1
 2 24
37 IPR012982 PADR1 InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
38 PF04057 Rep-A N Pfam 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
39 SM01344 NUC194 SMART 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
40 IPR015525 BRCA2 InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
41 IPR031657 REPA OB 2 InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
42 IPR031099 BRCA1-associated InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
43 PF09104 BRCA-2 OB3 Pfam 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
44 PF04423 Rad50 zn hook Pfam 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
45 IPR013908 DNA-repair Nbs1 C InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
46 PF12820 BRCT assoc Pfam 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
47 IPR015187 BRCA2 OB 1 InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
48 PF03439 Spt5-NGN Pfam 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
49 IPR025994 BRCA1 serine dom InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
50 IPR017071 TF Spt5 InterPro 1.548E-3 3.877E-3 2.413E-2
4.381E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 26 input genes in category / 240 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1309095 DNA Double-Strand Break Repair BioSystems: REACTOME 2.233E-26 5.359E-24 3.248E-23 5.359E-24 17 169
2 1270350 DNA Repair BioSystems: REACTOME 1.469E-21 1.763E-19 1.068E-18 3.525E-19 17 319
3 1309099 Homology Directed Repair BioSystems: REACTOME 2.291E-21 1.833E-19 1.111E-18 5.500E-19 14 140
4 1309110 Nonhomologous End-Joining (NHEJ) BioSystems: REACTOME 5.636E-19 3.382E-17 2.049E-16 1.353E-16 11 70
5 137959 BARD1 signaling events BioSystems: Pathway Interaction Database 4.569E-16 2.193E-14 1.329E-13 1.097E-13 8 29
6 1309100 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) BioSystems: REACTOME 9.971E-16 3.988E-14 2.417E-13 2.393E-13 11 134
7 1269754 G2/M DNA damage checkpoint BioSystems: REACTOME 2.205E-15 7.559E-14 4.581E-13 5.291E-13 10 96
8 1309101 Processing of DNA double-strand break ends BioSystems: REACTOME 3.034E-15 9.103E-14 5.517E-13 7.283E-13 10 99
9 1309104 Presynaptic phase of homologous DNA pairing and strand exchange BioSystems: REACTOME 8.071E-15 2.152E-13 1.304E-12 1.937E-12 8 40
10 1309103 Homologous DNA Pairing and Strand Exchange BioSystems: REACTOME 1.516E-14 3.639E-13 2.205E-12 3.639E-12 8 43
11 1309109 HDR through MMEJ (alt-NHEJ) BioSystems: REACTOME 2.045E-14 4.461E-13 2.704E-12 4.908E-12 6 11
12 1309102 HDR through Homologous Recombination (HRR) BioSystems: REACTOME 8.453E-13 1.578E-11 9.564E-11 2.029E-10 8 69
13 1269753 G2/M Checkpoints BioSystems: REACTOME 8.548E-13 1.578E-11 9.564E-11 2.052E-10 10 172
14 83046 Homologous recombination BioSystems: KEGG 1.539E-12 2.638E-11 1.598E-10 3.693E-10 7 41
15 1309098 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks BioSystems: REACTOME 1.889E-12 3.023E-11 1.832E-10 4.534E-10 8 76
16 1309096 DNA Double Strand Break Response BioSystems: REACTOME 2.105E-12 3.158E-11 1.914E-10 5.053E-10 8 77
17 M9703 Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility MSigDB C2 BIOCARTA (v6.0) 2.369E-12 3.344E-11 2.027E-10 5.685E-10 6 21
18 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 2.997E-12 3.996E-11 2.422E-10 7.193E-10 12 374
19 1269742 Cell Cycle Checkpoints BioSystems: REACTOME 4.731E-12 5.975E-11 3.621E-10 1.135E-9 10 204
20 1309107 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BioSystems: REACTOME 1.282E-11 1.538E-10 9.319E-10 3.076E-9 6 27
21 83047 Non-homologous end-joining BioSystems: KEGG 3.361E-11 3.841E-10 2.328E-9 8.066E-9 5 13
22 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 5.154E-11 5.623E-10 3.408E-9 1.237E-8 7 66
23 1309106 Resolution of D-loop Structures through Holliday Junction Intermediates BioSystems: REACTOME 6.950E-11 7.252E-10 4.395E-9 1.668E-8 6 35
24 1309105 Resolution of D-Loop Structures BioSystems: REACTOME 8.329E-11 8.329E-10 5.047E-9 1.999E-8 6 36
25 1309108 HDR through Single Strand Annealing (SSA) BioSystems: REACTOME 1.177E-10 1.130E-9 6.848E-9 2.825E-8 6 38
26 M10628 ATM Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 4.009E-10 3.701E-9 2.243E-8 9.622E-8 5 20
27 1383080 Regulation of TP53 Activity through Phosphorylation BioSystems: REACTOME 6.047E-10 5.375E-9 3.257E-8 1.451E-7 7 93
28 1269865 Meiosis BioSystems: REACTOME 4.112E-9 3.525E-8 2.136E-7 9.869E-7 7 122
29 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 6.357E-9 5.261E-8 3.188E-7 1.526E-6 6 72
30 PW:0000202 homologous recombination of double-strand break repair Pathway Ontology 8.086E-9 6.469E-8 3.920E-7 1.941E-6 3 3
31 1269273 IRF3-mediated induction of type I IFN BioSystems: REACTOME 1.055E-8 8.166E-8 4.949E-7 2.531E-6 4 13
32 1269866 Meiotic recombination BioSystems: REACTOME 2.309E-8 1.732E-7 1.050E-6 5.542E-6 6 89
33 1269272 STING mediated induction of host immune responses BioSystems: REACTOME 2.674E-8 1.944E-7 1.178E-6 6.416E-6 4 16
34 1383076 Regulation of TP53 Activity BioSystems: REACTOME 2.964E-8 2.092E-7 1.268E-6 7.113E-6 7 162
35 1268743 SUMO E3 ligases SUMOylate target proteins BioSystems: REACTOME 5.906E-8 4.050E-7 2.454E-6 1.417E-5 6 104
36 1268738 SUMOylation BioSystems: REACTOME 8.268E-8 5.512E-7 3.340E-6 1.984E-5 6 110
37 138085 Coregulation of Androgen receptor activity BioSystems: Pathway Interaction Database 1.028E-7 6.667E-7 4.040E-6 2.467E-5 5 57
38 1309097 Sensing of DNA Double Strand Breaks BioSystems: REACTOME 1.610E-7 1.017E-6 6.164E-6 3.865E-5 3 6
39 1270359 Resolution of Abasic Sites (AP sites) BioSystems: REACTOME 9.418E-7 5.651E-6 3.424E-5 2.260E-4 4 37
40 1270351 Base Excision Repair BioSystems: REACTOME 9.418E-7 5.651E-6 3.424E-5 2.260E-4 4 37
41 1269268 Cytosolic sensors of pathogen-associated DNA BioSystems: REACTOME 1.178E-5 6.896E-5 4.179E-4 2.828E-3 4 69
42 1269058 HIV Life Cycle BioSystems: REACTOME 1.447E-5 8.269E-5 5.011E-4 3.473E-3 5 154
43 M8560 Cell Cycle: G2/M Checkpoint MSigDB C2 BIOCARTA (v6.0) 1.590E-5 8.671E-5 5.254E-4 3.815E-3 3 24
44 1270364 Resolution of AP sites via the multiple-nucleotide patch replacement pathway BioSystems: REACTOME 1.590E-5 8.671E-5 5.254E-4 3.815E-3 3 24
45 1269078 Abortive elongation of HIV-1 transcript in the absence of Tat BioSystems: REACTOME 1.804E-5 9.621E-5 5.830E-4 4.329E-3 3 25
46 1268744 SUMOylation of DNA damage response and repair proteins BioSystems: REACTOME 1.919E-5 1.001E-4 6.068E-4 4.606E-3 4 78
47 1270429 DNA Damage/Telomere Stress Induced Senescence BioSystems: REACTOME 2.122E-5 1.084E-4 6.567E-4 5.093E-3 4 80
48 1309112 Global Genome Nucleotide Excision Repair (GG-NER) BioSystems: REACTOME 2.698E-5 1.349E-4 8.173E-4 6.474E-3 4 85
49 83043 Base excision repair BioSystems: KEGG 4.232E-5 2.073E-4 1.256E-3 1.016E-2 3 33
50 1269683 Formation of the Early Elongation Complex BioSystems: REACTOME 5.063E-5 2.382E-4 1.444E-3 1.215E-2 3 35
Show 45 more annotations

8: Pubmed [Display Chart] 29 input genes in category / 11949 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 8.201E-24 9.799E-20 9.765E-19 9.799E-20 11 68
2 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 1.899E-23 1.135E-19 1.131E-18 2.270E-19 11 73
3 20610542 Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. Pubmed 9.776E-23 3.894E-19 3.880E-18 1.168E-18 9 27
4 19064572 Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Pubmed 1.980E-21 5.915E-18 5.894E-17 2.366E-17 12 170
5 19690177 Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. Pubmed 2.984E-19 7.131E-16 7.106E-15 3.565E-15 8 31
6 27637333 Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. Pubmed 5.298E-19 1.055E-15 1.052E-14 6.331E-15 11 178
7 20644561 A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. Pubmed 2.561E-18 3.973E-15 3.960E-14 3.060E-14 9 75
8 19135898 Purification of proteins associated with specific genomic Loci. Pubmed 2.904E-18 3.973E-15 3.960E-14 3.470E-14 9 76
9 15100233 The human Rap1 protein complex and modulation of telomere length. Pubmed 3.083E-18 3.973E-15 3.960E-14 3.684E-14 6 8
10 23329831 Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. Pubmed 3.325E-18 3.973E-15 3.960E-14 3.973E-14 7 19
11 28192407 TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Pubmed 1.385E-17 1.505E-14 1.500E-13 1.655E-13 10 152
12 10608806 Substrate specificities and identification of putative substrates of ATM kinase family members. Pubmed 3.163E-17 3.149E-14 3.138E-13 3.779E-13 7 25
13 19536092 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. Pubmed 4.551E-17 4.046E-14 4.033E-13 5.439E-13 8 55
14 12607005 MDC1 is a mediator of the mammalian DNA damage checkpoint. Pubmed 5.080E-17 4.046E-14 4.033E-13 6.070E-13 6 11
15 19584272 Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. Pubmed 5.080E-17 4.046E-14 4.033E-13 6.070E-13 6 11
16 19394292 Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Pubmed 6.599E-17 4.928E-14 4.911E-13 7.885E-13 9 106
17 16391231 Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Pubmed 1.015E-16 7.137E-14 7.113E-13 1.213E-12 6 12
18 20813000 Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. Pubmed 1.725E-16 1.145E-13 1.141E-12 2.061E-12 7 31
19 19714462 Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. Pubmed 2.799E-16 1.761E-13 1.754E-12 3.345E-12 7 33
20 19661379 Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Pubmed 5.492E-16 3.125E-13 3.114E-12 6.562E-12 6 15
21 20232390 Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. Pubmed 5.492E-16 3.125E-13 3.114E-12 6.562E-12 6 15
22 19116388 A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. Pubmed 6.733E-16 3.657E-13 3.644E-12 8.045E-12 7 37
23 24332808 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Pubmed 7.098E-16 3.688E-13 3.675E-12 8.482E-12 11 340
24 20453000 A Large-scale genetic association study of esophageal adenocarcinoma risk. Pubmed 1.008E-15 4.834E-13 4.817E-12 1.204E-11 11 351
25 19181665 Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation. Pubmed 1.052E-15 4.834E-13 4.817E-12 1.257E-11 5 6
26 18001824 RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Pubmed 1.052E-15 4.834E-13 4.817E-12 1.257E-11 5 6
27 18950845 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. Pubmed 2.597E-15 1.149E-12 1.145E-11 3.103E-11 8 89
28 16794079 A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Pubmed 3.680E-15 1.418E-12 1.413E-11 4.397E-11 5 7
29 18001825 RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Pubmed 3.680E-15 1.418E-12 1.413E-11 4.397E-11 5 7
30 23115235 The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. Pubmed 3.680E-15 1.418E-12 1.413E-11 4.397E-11 5 7
31 11504724 Redistribution of BRCA1 among four different protein complexes following replication blockage. Pubmed 3.680E-15 1.418E-12 1.413E-11 4.397E-11 5 7
32 19074885 Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Pubmed 8.227E-15 3.072E-12 3.062E-11 9.831E-11 9 179
33 15456891 Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Pubmed 9.807E-15 3.551E-12 3.539E-11 1.172E-10 5 8
34 20731661 Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer. Pubmed 2.512E-14 8.828E-12 8.797E-11 3.001E-10 6 26
35 19303849 A role of DNA-PK for the metabolic gene regulation in response to insulin. Pubmed 4.409E-14 1.505E-11 1.500E-10 5.268E-10 5 10
36 18406329 FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Pubmed 8.078E-14 2.540E-11 2.531E-10 9.652E-10 5 11
37 15758953 Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Pubmed 8.078E-14 2.540E-11 2.531E-10 9.652E-10 5 11
38 15383534 Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. Pubmed 8.078E-14 2.540E-11 2.531E-10 9.652E-10 5 11
39 15140983 Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. Pubmed 1.384E-13 4.241E-11 4.226E-10 1.654E-9 5 12
40 19064565 Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk. Pubmed 2.248E-13 6.403E-11 6.381E-10 2.686E-9 5 13
41 10426999 Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
42 18678890 MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
43 20224574 A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
44 15377652 MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
45 11070027 DNA-Dependent protein kinase is not required for efficient lentivirus integration. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
46 15653682 DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
47 17700070 Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
48 19383352 Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
49 18411308 Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
50 15180989 Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. Pubmed 2.679E-13 6.403E-11 6.381E-10 3.202E-9 4 4
Show 45 more annotations

9: Interaction [Display Chart] 29 input genes in category / 2504 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NBN NBN interactions 1.266E-22 3.170E-19 2.664E-18 3.170E-19 13 98
2 int:XRCC5 XRCC5 interactions 3.801E-20 4.759E-17 3.999E-16 9.517E-17 15 278
3 int:H2AFX H2AFX interactions 1.627E-19 1.358E-16 1.141E-15 4.074E-16 15 306
4 int:MRE11 MRE11 interactions 1.310E-18 7.826E-16 6.576E-15 3.280E-15 12 137
5 int:ATM ATM interactions 1.563E-18 7.826E-16 6.576E-15 3.913E-15 13 197
6 int:PARP1 PARP1 interactions 3.748E-18 1.559E-15 1.310E-14 9.384E-15 14 286
7 int:MSH2 MSH2 interactions 4.358E-18 1.559E-15 1.310E-14 1.091E-14 12 151
8 int:MSH6 MSH6 interactions 5.906E-18 1.849E-15 1.553E-14 1.479E-14 11 105
9 int:XRCC6 XRCC6 interactions 3.050E-17 8.485E-15 7.130E-14 7.636E-14 14 332
10 int:TP53BP1 TP53BP1 interactions 8.024E-16 2.009E-13 1.688E-12 2.009E-12 11 162
11 int:RPA2 RPA2 interactions 3.847E-15 8.756E-13 7.358E-12 9.632E-12 14 470
12 int:NFATC2 NFATC2 interactions 4.756E-15 9.924E-13 8.339E-12 1.191E-11 11 190
13 int:BARD1 BARD1 interactions 7.913E-15 1.487E-12 1.250E-11 1.981E-11 12 280
14 int:RPA1 RPA1 interactions 8.315E-15 1.487E-12 1.250E-11 2.082E-11 14 497
15 int:MDC1 MDC1 interactions 9.918E-15 1.656E-12 1.391E-11 2.484E-11 11 203
16 int:BLM BLM interactions 1.217E-14 1.905E-12 1.601E-11 3.048E-11 10 140
17 int:SUMO2 SUMO2 interactions 1.779E-14 2.621E-12 2.203E-11 4.456E-11 11 214
18 int:WRN WRN interactions 2.082E-14 2.896E-12 2.434E-11 5.213E-11 8 55
19 int:PCNA PCNA interactions 3.906E-14 5.148E-12 4.326E-11 9.781E-11 12 320
20 int:RNF8 RNF8 interactions 1.409E-13 1.717E-11 1.443E-10 3.527E-10 8 69
21 int:DCLRE1C DCLRE1C interactions 1.440E-13 1.717E-11 1.443E-10 3.606E-10 7 37
22 int:RAD50 RAD50 interactions 2.498E-13 2.843E-11 2.389E-10 6.255E-10 9 123
23 int:CHEK2 CHEK2 interactions 2.691E-13 2.929E-11 2.462E-10 6.738E-10 9 124
24 int:XRCC1 XRCC1 interactions 2.824E-13 2.947E-11 2.476E-10 7.072E-10 8 75
25 int:TOP1 TOP1 interactions 4.722E-13 4.730E-11 3.974E-10 1.182E-9 10 201
26 int:PRKDC PRKDC interactions 5.622E-13 5.414E-11 4.550E-10 1.408E-9 11 293
27 int:RFC1 RFC1 interactions 7.229E-13 6.704E-11 5.633E-10 1.810E-9 8 84
28 int:RECQL5 RECQL5 interactions 2.784E-12 2.489E-10 2.092E-9 6.970E-9 7 55
29 int:NKX2-1 NKX2-1 interactions 6.522E-12 5.631E-10 4.732E-9 1.633E-8 9 176
30 int:TOPBP1 TOPBP1 interactions 9.446E-12 7.884E-10 6.625E-9 2.365E-8 7 65
31 int:RBBP8 RBBP8 interactions 1.618E-11 1.266E-9 1.064E-8 4.051E-8 7 70
32 int:CHD1L CHD1L interactions 1.618E-11 1.266E-9 1.064E-8 4.051E-8 7 70
33 int:RPA3 RPA3 interactions 2.031E-11 1.541E-9 1.295E-8 5.086E-8 11 408
34 int:LIG3 LIG3 interactions 2.192E-11 1.614E-9 1.356E-8 5.488E-8 7 73
35 int:ATRX ATRX interactions 3.220E-11 2.304E-9 1.936E-8 8.064E-8 7 77
36 int:RAD51 RAD51 interactions 5.534E-11 3.850E-9 3.235E-8 1.386E-7 8 143
37 int:BRIP1 BRIP1 interactions 6.506E-11 4.403E-9 3.700E-8 1.629E-7 6 43
38 int:CHEK1 CHEK1 interactions 1.233E-10 8.127E-9 6.829E-8 3.088E-7 8 158
39 int:TERF2 TERF2 interactions 2.901E-10 1.863E-8 1.565E-7 7.265E-7 9 269
40 int:BRCA2 BRCA2 interactions 3.380E-10 2.116E-8 1.778E-7 8.462E-7 7 107
41 int:ATR ATR interactions 9.576E-10 5.849E-8 4.915E-7 2.398E-6 7 124
42 int:PNKP PNKP interactions 1.037E-9 6.181E-8 5.194E-7 2.596E-6 6 67
43 int:ILF2 ILF2 interactions 1.105E-9 6.435E-8 5.407E-7 2.767E-6 9 313
44 int:CHAF1A CHAF1A interactions 1.486E-9 8.455E-8 7.105E-7 3.720E-6 8 216
45 int:RFC2 RFC2 interactions 1.614E-9 8.982E-8 7.548E-7 4.042E-6 6 72
46 int:MACROD1 MACROD1 interactions 1.886E-9 1.026E-7 8.625E-7 4.722E-6 5 33
47 int:POU2F1 POU2F1 interactions 2.073E-9 1.105E-7 9.282E-7 5.192E-6 6 75
48 int:APLF APLF interactions 2.985E-9 1.557E-7 1.309E-6 7.475E-6 5 36
49 int:MLH1 MLH1 interactions 4.176E-9 2.134E-7 1.793E-6 1.046E-5 7 153
50 int:TERF2IP TERF2IP interactions 4.781E-9 2.394E-7 2.012E-6 1.197E-5 7 156
Show 45 more annotations

10: Cytoband [Display Chart] 29 input genes in category / 28 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q15-q21 15q15-q21 3.343E-3 3.115E-2
1.223E-1
9.359E-2
 1 4
2 1q41-q42 1q41-q42 5.010E-3 3.115E-2
1.223E-1
1.403E-1
 1 6
3 8q11 8q11 5.010E-3 3.115E-2
1.223E-1
1.403E-1
 1 6
4 2q34-q35 2q34-q35 5.843E-3 3.115E-2
1.223E-1
1.636E-1
 1 7
5 14q11.2-q12 14q11.2-q12 6.675E-3 3.115E-2
1.223E-1
1.869E-1
 1 8
6 3p24 3p24 6.675E-3 3.115E-2
1.223E-1
1.869E-1
 1 8
7 8q21 8q21 9.996E-3 3.998E-2
1.570E-1
2.799E-1
 1 12
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 18 input genes in category / 95 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 17 input genes in category / 19 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1336 BRCA1 C complex genenames.org 2.606E-12 4.951E-11 1.756E-10 4.951E-11 4 5
2 1344 BRCA1 C complex|MRN complex genenames.org 6.776E-10 6.437E-9 2.284E-8 1.287E-8 3 3
3 1335 Fanconi anemia complementation groups|DNA helicases|BRCA1 B complex genenames.org 4.925E-6 3.119E-5 1.107E-4 9.358E-5 2 4
4 684 Poly(ADP-ribose) polymerases genenames.org 1.108E-4 5.265E-4 1.868E-3 2.106E-3 2 17
5 548 Fanconi anemia complementation groups genenames.org 1.546E-4 5.875E-4 2.084E-3 2.937E-3 2 20
6 94 Zinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases genenames.org 1.868E-3 5.915E-3 2.099E-2 3.549E-2 1 2
7 1050 Topoisomerases genenames.org 5.594E-3 1.181E-2 4.190E-2
1.063E-1
 1 6
8 1334 Shelterin complex genenames.org 5.594E-3 1.181E-2 4.190E-2
1.063E-1
 1 6
9 1328 BRCA1 A complex genenames.org 5.594E-3 1.181E-2 4.190E-2
1.063E-1
 1 6
10 26 Zinc fingers genenames.org 1.393E-2 2.643E-2
9.377E-2
2.647E-1
 1 15
11 1167 INO80 complex |DNA helicases genenames.org 1.577E-2 2.643E-2
9.377E-2
2.997E-1
 1 17
12 1269 Nucleotide excision repair genenames.org 1.669E-2 2.643E-2
9.377E-2
3.172E-1
 1 18
13 567 Glutathione S-transferases genenames.org 2.311E-2 3.378E-2
1.199E-1
4.392E-1
 1 25
14 58 Ring finger proteins|Tripartite motif containing genenames.org 2.666E-2 3.390E-2
1.203E-1
5.065E-1
 2 275
15 473 Cyclins genenames.org 2.677E-2 3.390E-2
1.203E-1
5.085E-1
 1 29
16 780 RNA binding motif containing|Tudor domain containing genenames.org 3.403E-2 4.041E-2
1.434E-1
6.466E-1
 1 37
Show 11 more annotations

13: Coexpression [Display Chart] 29 input genes in category / 2644 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.955E-23 1.046E-19 8.843E-19 1.046E-19 15 230
2 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.189E-21 1.571E-18 1.329E-17 3.143E-18 12 101
3 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 3.226E-14 2.843E-11 2.404E-10 8.528E-11 10 200
4 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.392E-13 4.225E-10 3.574E-9 1.690E-9 7 58
5 17150101-TableS1h Human Breast Troester06 364genes up DOX-MCF7 GeneSigDB 1.516E-9 6.693E-7 5.661E-6 4.009E-6 8 282
6 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.519E-9 6.693E-7 5.661E-6 4.016E-6 9 423
7 M5839 Proteins that regulate activity of PRKDC [GeneID=5591]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.690E-9 1.016E-6 8.594E-6 7.113E-6 4 15
8 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.878E-9 2.273E-6 1.923E-5 1.819E-5 8 342
9 M4495 Substrates of PRKDC [GeneID=5591]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.507E-9 2.793E-6 2.362E-5 2.514E-5 4 20
10 M15305 Genes constituting the BRCA-centered network (BCN). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.270E-7 8.645E-5 7.312E-4 8.645E-4 5 117
11 19695104-AF2 Human Breast Lin09 128genes GeneSigDB 1.626E-6 3.825E-4 3.235E-3 4.299E-3 4 69
12 20103679-ST3-B Human Breast Wood10 416genes GeneSigDB 1.736E-6 3.825E-4 3.235E-3 4.590E-3 6 302
13 M18811 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.961E-6 3.988E-4 3.373E-3 5.185E-3 5 168
14 19695104-AF1-5 Human Breast Lin09 24genes GeneSigDB 2.319E-6 4.380E-4 3.704E-3 6.132E-3 3 21
15 15277230-Table4 Human Thyroid Morrison04 24genes GeneSigDB 2.683E-6 4.546E-4 3.845E-3 7.094E-3 3 22
16 M2993 Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.751E-6 4.546E-4 3.845E-3 7.274E-3 5 180
17 15374877-Table2 Human StemCell Manalo05 108genes GeneSigDB 3.097E-6 4.817E-4 4.074E-3 8.188E-3 4 81
18 19190334-Table2 Human Breast Burga09 25genes GeneSigDB 3.997E-6 5.871E-4 4.965E-3 1.057E-2 3 25
19 M3940 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 4.605E-6 6.088E-4 5.149E-3 1.218E-2 5 200
20 M3197 Genes down-regulated in comparison of IgD- peripheral blood B cells versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 4.605E-6 6.088E-4 5.149E-3 1.218E-2 5 200
21 15741219-Table3 Human StemCell Roth05 33genes GeneSigDB 9.418E-6 1.186E-3 1.003E-2 2.490E-2 3 33
22 M15150 Genes up-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.231E-5 1.480E-3 1.251E-2 3.255E-2 6 425
23 M6244 Genes with a high basal transcription state in undifferentiated embryonic carcinoma cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.268E-5 2.608E-3 2.205E-2
5.997E-2
 2 6
24 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.209E-5 3.527E-3 2.983E-2
8.486E-2
 5 299
25 16699793-Table1 Human pancreas Miyake06 52genes GeneSigDB 3.335E-5 3.527E-3 2.983E-2
8.818E-2
 3 50
26 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 3.553E-5 3.613E-3 3.056E-2
9.394E-2
 4 150
27 19695104-AF1-3 Human Breast Lin09 10genes GeneSigDB 4.228E-5 4.140E-3 3.501E-2
1.118E-1
 2 8
28 18221536-Table1 Human Breast Roll08 64genes GeneSigDB 4.445E-5 4.198E-3 3.550E-2
1.175E-1
 3 55
29 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.704E-5 4.289E-3 3.628E-2
1.244E-1
 5 324
30 M2942 Genes down-regulated in gamma delta intraepithelial lymphocytes from colon: control versus colitis induced by dextran sulfate sodium (DSS). MSigDB C7: Immunologic Signatures (v6.0) 5.789E-5 5.013E-3 4.240E-2
1.531E-1
 4 170
31 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.067E-5 5.013E-3 4.240E-2
1.604E-1
 3 61
32 M4493 Genes whose promoters were bound by E2F1 and E2F4 [GeneID=1869;1874] in the primary fibroblasts WI-38, by ChIP on chip assay. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.067E-5 5.013E-3 4.240E-2
1.604E-1
 3 61
33 M5354 Genes required for proliferation of DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.479E-5 5.039E-3 4.262E-2
1.713E-1
 4 175
34 M3456 Genes identified by ChIP within the high-affinity group of MYC [GeneID=4609] targets. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.544E-5 5.039E-3 4.262E-2
1.995E-1
 4 182
35 M1859 Genes down-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.951E-5 5.039E-3 4.262E-2
2.102E-1
 5 362
36 16585155-TableS1 Human Colon Watanabe06 214genes GeneSigDB 9.279E-5 5.039E-3 4.262E-2
2.453E-1
 4 192
37 17313671-SuppTable1e Human Leukemia Li07 12genes DNARepair GeneSigDB 9.934E-5 5.039E-3 4.262E-2
2.627E-1
 2 12
38 19855078-TableS5 Human Leukemia Stumpel09 75genes GeneSigDB 9.962E-5 5.039E-3 4.262E-2
2.634E-1
 3 72
39 M9193 Genes down-regulated in normal bone marrow plasma cells (BMPC) compared to polyclonal plasmablasts (PPC) that also distinguished multiple myeloma (MM) samples by expression of levels of TACI [GeneID=23495]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.038E-4 5.039E-3 4.262E-2
2.744E-1
 3 73
40 M6406 Genes up-regulated in monocytes: untreated versus M. tuberculosis 19 kDa lipopeptide (12h). MSigDB C7: Immunologic Signatures (v6.0) 1.045E-4 5.039E-3 4.262E-2
2.763E-1
 4 198
41 M4704 Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
42 M3168 Genes up-regulated in comparison of germinal center B cells versus naive B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
43 M4868 Genes up-regulated in comparison of NKT cells versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
44 M4529 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
45 M9419 Genes up-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
46 M6003 Genes down-regulated in macrophages with SOCS3 [GeneID=9021]: untreated versus IL6 [GeneID=3569] for 400min. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
47 M8768 Genes down-regulated in dendritic cells with knockout of NLRP10 [GeneID=338322]: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
48 M6837 Genes down-regulated in CD4 [GeneID=920] T cells from lymph nodes: naïve versus day 7 after immunization. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
49 M7376 Genes down-regulated in the activated CD4 [GeneID=920] T cells (48h): control versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
50 M4626 Genes up-regulated in comparison of untreated CD25+ T effector cells at day 10 versus untreated CD25- T cells at day 10. MSigDB C7: Immunologic Signatures (v6.0) 1.086E-4 5.039E-3 4.262E-2
2.872E-1
 4 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 29 input genes in category / 1359 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e11.5 M PrimGermCell Oct k2 1000 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.713E-8 5.046E-5 3.932E-4 5.046E-5 7 258
2 gudmap dev gonad e13.5 F MeioticGermCell Oct k2 1000 dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.642E-7 2.475E-4 1.928E-3 4.950E-4 7 361
3 gudmap dev gonad e13.5 F MeioticGermCell Oct 500 dev gonad e13.5 F MeioticGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.615E-7 2.543E-4 1.982E-3 7.630E-4 7 385
4 gudmap dev gonad e12.5 M GermCellTestis Oct k2 1000 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.162E-6 3.947E-4 3.076E-3 1.579E-3 6 266
5 GSM538352 500 B cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.020E-5 1.859E-3 1.448E-2 1.386E-2 6 388
6 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.161E-5 1.859E-3 1.448E-2 1.578E-2 6 397
7 gudmap dev gonad e12.5 F GermCellOvary Oct 500 dev gonad e12.5 F GermCellOvary Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.319E-5 1.859E-3 1.448E-2 1.792E-2 6 406
8 gudmap dev gonad e12.5 F GermCellOvary Oct k3 500 dev gonad e12.5 F GermCellOvary Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.515E-5 1.859E-3 1.448E-2 2.059E-2 4 114
9 GSM538350 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.555E-5 1.859E-3 1.448E-2 2.114E-2 6 418
10 GSM538348 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.576E-5 1.859E-3 1.448E-2 2.142E-2 6 419
11 GSM538355 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.641E-5 1.859E-3 1.448E-2 2.231E-2 6 422
12 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.641E-5 1.859E-3 1.448E-2 2.231E-2 6 422
13 gudmap dev gonad e11.5 F PrimGermCell Oct k3 1000 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.767E-5 2.892E-3 2.254E-2 3.760E-2 6 463
14 gudmap dev gonad e13.5 F MeioticGermCell Oct k2 500 dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.686E-5 4.549E-3 3.545E-2
6.369E-2
 4 152
15 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 1000 K2 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 5.098E-5 4.619E-3 3.599E-2
6.928E-2
 5 311
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Normal fetal kidney MNP RCC2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Normal fetal kidney MNP RCC2 Adult, Development, and Cancer types 9.841E-5 8.358E-3
6.513E-2
1.337E-1
 4 184
17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Adult, Development, and Cancer types 1.183E-4 9.221E-3
7.185E-2
1.608E-1
 4 193
18 GSM538418 500 B cells, proB.FrBC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-1 Immgen.org, GSE15907 1.263E-4 9.221E-3
7.185E-2
1.716E-1
 5 377
19 gudmap dev gonad e12.5 M GermCellTestis Oct 500 dev gonad e12.5 M GermCellTestis Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.427E-4 9.221E-3
7.185E-2
1.940E-1
 5 387
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK7 Adult, Development, and Cancer types 1.443E-4 9.221E-3
7.185E-2
1.962E-1
 3 77
21 GSM538340 500 B cells, preB.FrD.FL, AA4.1+ IgM- CD19+ CD43- CD24+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.570E-4 9.221E-3
7.185E-2
2.134E-1
 5 395
22 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 1.646E-4 9.221E-3
7.185E-2
2.237E-1
 5 399
23 GSM538345 500 B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.646E-4 9.221E-3
7.185E-2
2.237E-1
 5 399
24 GSM538358 500 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.665E-4 9.221E-3
7.185E-2
2.263E-1
 5 400
25 GSM399450 500 B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2 Immgen.org, GSE15907 1.704E-4 9.221E-3
7.185E-2
2.316E-1
 5 402
26 GSM538343 500 B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R+, Bone marrow, avg-1 Immgen.org, GSE15907 1.764E-4 9.221E-3
7.185E-2
2.397E-1
 5 405
27 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 1.847E-4 9.295E-3
7.243E-2
2.510E-1
 5 409
28 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.932E-4 9.377E-3
7.307E-2
2.626E-1
 5 413
29 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 2.020E-4 9.462E-3
7.373E-2
2.746E-1
 5 417
30 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 2.089E-4 9.462E-3
7.373E-2
2.839E-1
 5 420
31 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal VHL RCC Junk/Kidney Normal VHL RCC IN17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal VHL RCC Junk/Kidney Normal VHL RCC IN17 Adult, Development, and Cancer types 2.946E-4 1.291E-2
1.006E-1
4.003E-1
 3 98
32 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes 3.282E-4 1.394E-2
1.086E-1
4.460E-1
 4 252
33 gudmap dev gonad e11.5 F PrimGermCell Oct k2 1000 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.508E-4 1.442E-2
1.124E-1
4.767E-1
 3 104
34 gudmap dev gonad e12.5 M GermCellTestis Oct k1 500 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.608E-4 1.442E-2
1.124E-1
4.903E-1
 3 105
35 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 4.015E-4 1.559E-2
1.215E-1
5.456E-1
 5 484
36 Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ MultiLin Top 200 Genes Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ MultiLin Top 200 Genes 6.412E-4 2.421E-2
1.886E-1
8.714E-1
 4 301
37 gudmap kidney P3 CapMes Crym k4 1000 kidney P3 CapMes Crym k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.781E-4 2.858E-2
2.227E-1
1.000E0
 4 317
38 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Mgp/Endothelial Tip.Dcn.Mgp/Hippocampus BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Mgp/Endothelial Tip.Dcn.Mgp/Hippocampus BrainMap 9.427E-4 3.372E-2
2.627E-1
1.000E0
 3 146
39 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes 9.877E-4 3.442E-2
2.682E-1
1.000E0
 4 338
40 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/early fetal/IMM e Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/early fetal/IMM e Fetal, Development 1.329E-3 4.404E-2
3.431E-1
1.000E0
 1 1
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour VHL RCC R U/Kidney Tumour VHL RCC R15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour VHL RCC R U/Kidney Tumour VHL RCC R15 Adult, Development, and Cancer types 1.329E-3 4.404E-2
3.431E-1
1.000E0
 1 1
42 gudmap dev gonad e11.5 M PrimGermCell Oct 500 dev gonad e11.5 M PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.464E-3 4.625E-2
3.604E-1
1.000E0
 4 376
43 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.464E-3 4.625E-2
3.604E-1
1.000E0
 4 376
44 GSM538207 500 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 1.521E-3 4.699E-2
3.662E-1
1.000E0
 4 380
45 gudmap dev gonad e11.5 F PrimGermCell Oct 500 dev gonad e11.5 F PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.611E-3 4.866E-2
3.792E-1
1.000E0
 4 386
46 gudmap dev gonad e13.5 M GermCell Oct 500 dev gonad e13.5 M GermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.769E-3 4.884E-2
3.805E-1
1.000E0
 4 396
47 GSM791108 500 Stem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2 Immgen.org, GSE15907 1.852E-3 4.884E-2
3.805E-1
1.000E0
 4 401
48 GSM791105 500 Stem Cells, SC.MDP.BM, Sca1- Flt3+ MCSFR+ cKithi, Bone marrow, avg-3 Immgen.org, GSE15907 1.869E-3 4.884E-2
3.805E-1
1.000E0
 4 402
49 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Top 200 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Top 200 1.973E-3 4.884E-2
3.805E-1
1.000E0
 4 408
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma Adult, Development, and Cancer types 2.008E-3 4.884E-2
3.805E-1
1.000E0
 3 190
Show 45 more annotations

15: Computational [Display Chart] 27 input genes in category / 184 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.247E-4 1.648E-2
9.549E-2
 2.295E-2 6 303
2 M15222 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.895E-4 1.648E-2
9.549E-2
 3.486E-2 5 205
3 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.714E-4 1.648E-2
9.549E-2
6.833E-2
 5 237
4 M5047 MORF DDB1 Neighborhood of DDB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.011E-4 1.648E-2
9.549E-2
7.380E-2
 5 241
5 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.098E-4 1.648E-2
9.549E-2
9.380E-2
 6 393
6 M3665 MORF CDC10 Neighborhood of CDC10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.373E-4 1.648E-2
9.549E-2
9.887E-2
 4 143
7 M19935 MORF CDC16 Neighborhood of CDC16 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.525E-4 2.504E-2
1.451E-1
1.753E-1
 3 73
8 M5038 MORF BECN1 Neighborhood of BECN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.427E-3 3.693E-2
2.140E-1
4.466E-1
 3 101
9 M1104 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.496E-3 3.693E-2
2.140E-1
4.594E-1
 3 102
10 M6308 GNF2 RPA1 Neighborhood of RPA1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.523E-3 3.693E-2
2.140E-1
4.642E-1
 2 28
11 M16797 MODULE 318 Genes in the cancer module 318. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.523E-3 3.693E-2
2.140E-1
4.642E-1
 2 28
12 M19951 GNF2 BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.523E-3 3.693E-2
2.140E-1
4.642E-1
 2 28
13 M1964 MORF PRKAG1 Neighborhood of PRKAG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.609E-3 3.693E-2
2.140E-1
4.801E-1
 4 219
14 M11605 MODULE 229 Genes in the cancer module 229. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.088E-3 3.993E-2
2.314E-1
5.683E-1
 2 31
15 M7126 MORF TERF2IP Neighborhood of TERF2IP MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.255E-3 3.993E-2
2.314E-1
5.990E-1
 3 112
16 M10327 MODULE 451 Genes in the cancer module 451. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.495E-3 4.019E-2
2.329E-1
6.431E-1
 2 33
17 M7493 MORF PHB Neighborhood of PHB MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.238E-3 4.587E-2
2.658E-1
7.798E-1
 3 123
18 M7191 MORF DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.961E-3 4.943E-2
2.864E-1
9.129E-1
 4 262
19 M18354 GNF2 NS Neighborhood of NS MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.104E-3 4.943E-2
2.864E-1
9.391E-1
 2 40
Show 14 more annotations

16: MicroRNA [Display Chart] 29 input genes in category / 721 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-505-3p:Functional MTI Functional MTI miRTarbase 1.976E-6 1.424E-3 1.020E-2 1.424E-3 4 223
2 hsa-miR-4307:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.357E-5 4.893E-3 3.502E-2 9.785E-3 3 114
3 hsa-miR-361-5p:Functional MTI Functional MTI miRTarbase 3.734E-5 8.975E-3
6.425E-2
 2.692E-2 3 160
4 hsa-miR-31-5p:Functional MTI Functional MTI miRTarbase 1.013E-4 1.825E-2
1.307E-1
7.301E-2
 3 224
5 hsa-miR-100-5p:Functional MTI Functional MTI miRTarbase 1.416E-4 2.042E-2
1.462E-1
1.021E-1
 3 251
6 hsa-miR-99b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.883E-4 2.263E-2
1.620E-1
1.358E-1
 2 50
7 hsa-miR-671-3p:mirSVR highEffct hsa-miR-671-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.186E-4 3.282E-2
2.349E-1
2.297E-1
 2 65
8 hsa-miR-29b-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.240E-4 3.821E-2
2.735E-1
3.057E-1
 2 75
9 hsa-miR-142-3p:Functional MTI Functional MTI miRTarbase 5.102E-4 3.902E-2
2.793E-1
3.678E-1
 3 389
10 hsa-miR-149-5p:Functional MTI Functional MTI miRTarbase 5.412E-4 3.902E-2
2.793E-1
3.902E-1
 3 397
11 hsa-miR-2114*:mirSVR highEffct hsa-miR-2114*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.775E-4 3.951E-2
2.829E-1
4.885E-1
 3 429
12 hsa-miR-323b-5p:mirSVR highEffct hsa-miR-323b-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.030E-4 3.951E-2
2.829E-1
5.789E-1
 3 455
13 hsa-miR-3186-5p:mirSVR highEffct hsa-miR-3186-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.280E-4 3.951E-2
2.829E-1
5.970E-1
 2 105
14 hsa-miR-139-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.280E-4 3.951E-2
2.829E-1
5.970E-1
 2 105
15 hsa-miR-1914*:mirSVR highEffct hsa-miR-1914*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.200E-4 3.951E-2
2.829E-1
6.633E-1
 3 477
16 hsa-miR-3925-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.026E-3 3.951E-2
2.829E-1
7.398E-1
 2 117
17 hsa-miR-4419b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.035E-3 3.951E-2
2.829E-1
7.464E-1
 3 497
18 hsa-miR-4478:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.041E-3 3.951E-2
2.829E-1
7.508E-1
 3 498
19 hsa-miR-3929:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.041E-3 3.951E-2
2.829E-1
7.508E-1
 3 498
20 hsa-miR-577:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.245E-3 4.487E-2
3.212E-1
8.974E-1
 2 129
21 hsa-miR-3180-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.525E-3 4.587E-2
3.283E-1
1.000E0
 2 143
22 hsa-miR-5584-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.525E-3 4.587E-2
3.283E-1
1.000E0
 2 143
23 hsa-miR-33a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.589E-3 4.587E-2
3.283E-1
1.000E0
 2 146
24 hsa-miR-8054:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.654E-3 4.587E-2
3.283E-1
1.000E0
 2 149
25 hsa-miR-548av-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.654E-3 4.587E-2
3.283E-1
1.000E0
 2 149
26 hsa-miR-548k:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.654E-3 4.587E-2
3.283E-1
1.000E0
 2 149
27 hsa-miR-23a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.788E-3 4.603E-2
3.295E-1
1.000E0
 2 155
28 hsa-miR-23b-5p:Functional MTI Functional MTI miRTarbase 1.788E-3 4.603E-2
3.295E-1
1.000E0
 2 155
Show 23 more annotations

17: Drug [Display Chart] 29 input genes in category / 6882 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C408982 CPG-oligonucleotide CTD 5.679E-29 3.908E-25 3.679E-24 3.908E-25 17 184
2 CID000005192 sebacate Stitch 7.626E-27 2.624E-23 2.470E-22 5.248E-23 16 181
3 CID000004156 methyl methanesulfonate Stitch 8.516E-26 1.954E-22 1.839E-21 5.861E-22 18 364
4 CID000002538 NSC302991 Stitch 4.884E-24 8.403E-21 7.910E-20 3.361E-20 17 353
5 ctd:C547185 riccardin D CTD 8.568E-21 1.120E-17 1.054E-16 5.897E-17 11 76
6 CID000005746 mitomycin C Stitch 9.766E-21 1.120E-17 1.054E-16 6.721E-17 14 241
7 CID000003657 hydroxyurea Stitch 8.341E-19 8.200E-16 7.719E-15 5.740E-15 15 438
8 CID005278396 KU55933 Stitch 8.541E-16 7.348E-13 6.917E-12 5.878E-12 8 48
9 CID000115150 ICRF-193 Stitch 2.344E-15 1.792E-12 1.687E-11 1.613E-11 8 54
10 CID000072271 UCN-01 Stitch 2.029E-13 1.397E-10 1.315E-9 1.397E-9 9 154
11 CID000006278 1,1,1-trichloroethane Stitch 2.283E-13 1.428E-10 1.344E-9 1.571E-9 9 156
12 ctd:D002166 Camptothecin CTD 3.405E-13 1.953E-10 1.838E-9 2.343E-9 9 163
13 CID009860529 NU7026 Stitch 1.054E-12 5.579E-10 5.252E-9 7.253E-9 5 11
14 ctd:C024352 fludarabine CTD 3.059E-12 1.504E-9 1.415E-8 2.105E-8 7 71
15 CID005282473 Zinostatino Stitch 6.040E-12 2.771E-9 2.609E-8 4.157E-8 7 78
16 ctd:C477361 LAQ824 CTD 8.983E-12 3.864E-9 3.637E-8 6.182E-8 6 40
17 ctd:C030090 phosphoramide mustard CTD 1.423E-11 5.761E-9 5.423E-8 9.794E-8 6 43
18 ctd:C005246 myristicin CTD 1.898E-11 7.257E-9 6.831E-8 1.306E-7 6 45
19 CID000002210 NSC351140 Stitch 2.141E-11 7.754E-9 7.300E-8 1.473E-7 9 258
20 CID000088505 DNA-PK inhibitor Stitch 2.634E-11 9.064E-9 8.533E-8 1.813E-7 5 19
21 CID000003422 AC1L1FWE Stitch 4.137E-11 1.356E-8 1.276E-7 2.847E-7 7 102
22 ctd:C521013 veliparib CTD 5.950E-11 1.861E-8 1.752E-7 4.095E-7 5 22
23 CID000003885 beta-lapachone Stitch 1.719E-10 5.142E-8 4.841E-7 1.183E-6 6 64
24 CID000005394 temozolomide Stitch 1.960E-10 5.620E-8 5.291E-7 1.349E-6 7 127
25 ctd:D014800 Vitallium CTD 5.347E-10 1.472E-7 1.386E-6 3.680E-6 8 244
26 ctd:C531550 olaparib CTD 1.030E-9 2.726E-7 2.566E-6 7.086E-6 4 12
27 CID000001174 uracil Stitch 1.156E-9 2.946E-7 2.773E-6 7.953E-6 8 269
28 CID000160683 n-butan-2-yl-l-homocysteine Stitch 4.208E-9 1.034E-6 9.735E-6 2.896E-5 5 49
29 CID000001720 4-AN Stitch 4.929E-9 1.170E-6 1.101E-5 3.392E-5 4 17
30 CID000005955 4NQO Stitch 6.502E-9 1.492E-6 1.404E-5 4.475E-5 6 116
31 CID009859309 IC86621 Stitch 7.354E-9 1.633E-6 1.537E-5 5.061E-5 3 4
32 ctd:D010984 Platinum CTD 1.001E-8 2.152E-6 2.026E-5 6.888E-5 4 20
33 CID000006261 1-methyl-2-nitro-1-nitrosoguanidine Stitch 1.568E-8 3.269E-6 3.078E-5 1.079E-4 7 238
34 CID000257281 NSC-85245 Stitch 1.824E-8 3.693E-6 3.476E-5 1.256E-4 4 23
35 CID000068703 B led Stitch 3.072E-8 6.040E-6 5.686E-5 2.114E-4 4 26
36 ctd:C009687 wortmannin CTD 3.454E-8 6.603E-6 6.216E-5 2.377E-4 7 267
37 CID000434213 NHS-B Stitch 4.868E-8 9.044E-6 8.514E-5 3.350E-4 4 29
38 CID005289542 UV-C Stitch 4.994E-8 9.044E-6 8.514E-5 3.437E-4 6 163
39 ctd:C495818 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one CTD 6.437E-8 1.136E-5 1.069E-4 4.430E-4 4 31
40 CID000444764 2-(oxalylamino)benzoic acid Stitch 8.843E-8 1.521E-5 1.432E-4 6.086E-4 5 89
41 CID000001340 1,5-isoquinolinediol Stitch 9.463E-8 1.588E-5 1.495E-4 6.512E-4 4 34
42 ctd:C013690 styrene oxide CTD 1.067E-7 1.749E-5 1.647E-4 7.346E-4 4 35
43 CID000104799 fotemustine Stitch 1.501E-7 2.348E-5 2.210E-4 1.033E-3 4 38
44 CID000099735 4-hydroxycyclophosphamide Stitch 1.501E-7 2.348E-5 2.210E-4 1.033E-3 4 38
45 ctd:D013662 Tea CTD 1.671E-7 2.555E-5 2.406E-4 1.150E-3 4 39
46 CID005287969 flavopiridol Stitch 2.643E-7 3.954E-5 3.722E-4 1.819E-3 6 216
47 CID000444209 AC1L9FX4 Stitch 2.746E-7 4.021E-5 3.785E-4 1.890E-3 4 44
48 CID000011254 diepoxybutane Stitch 2.928E-7 4.080E-5 3.841E-4 2.015E-3 5 113
49 ctd:C016274 bromoacetate CTD 3.011E-7 4.080E-5 3.841E-4 2.072E-3 4 45
50 ctd:C086538 4-amino-1,8-naphthalimide CTD 3.015E-7 4.080E-5 3.841E-4 2.075E-3 3 11
Show 45 more annotations

18: Disease [Display Chart] 29 input genes in category / 1209 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0015625 Fanconi Anemia DisGeNET Curated 6.186E-16 7.479E-13 5.740E-12 7.479E-13 13 285
2 C0346153 Breast Cancer, Familial DisGeNET Curated 3.881E-14 2.346E-11 1.801E-10 4.692E-11 10 144
3 C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 2.795E-13 1.126E-10 8.644E-10 3.379E-10 11 252
4 C0004135 Ataxia Telangiectasia DisGeNET Curated 1.893E-12 5.721E-10 4.391E-9 2.288E-9 12 407
5 C0008626 Congenital chromosomal disease DisGeNET Curated 2.055E-11 4.968E-9 3.813E-8 2.484E-8 12 499
6 C0677776 Hereditary Breast and Ovarian Cancer Syndrome DisGeNET Curated 2.847E-10 5.737E-8 4.403E-7 3.442E-7 6 50
7 C0398791 Nijmegen Breakage Syndrome DisGeNET Curated 7.985E-10 1.379E-7 1.058E-6 9.654E-7 6 59
8 C1333600 Hereditary Malignant Neoplasm DisGeNET BeFree 1.085E-9 1.640E-7 1.259E-6 1.312E-6 6 62
9 C0007107 Malignant neoplasm of larynx DisGeNET BeFree 2.725E-9 3.661E-7 2.810E-6 3.295E-6 7 132
10 C1336076 Sporadic Breast Carcinoma DisGeNET BeFree 1.137E-8 1.374E-6 1.055E-5 1.374E-5 7 162
11 C0595989 Carcinoma of larynx DisGeNET Curated 1.653E-8 1.817E-6 1.395E-5 1.999E-5 7 171
12 C0278996 Cancer of Head and Neck DisGeNET Curated 3.461E-8 3.487E-6 2.677E-5 4.185E-5 9 426
13 C0023531 Leukoplakia DisGeNET Curated 4.576E-8 4.138E-6 3.176E-5 5.533E-5 5 56
14 C1859598 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA DisGeNET Curated 4.846E-8 4.138E-6 3.176E-5 5.859E-5 4 21
15 C1333990 Hereditary Nonpolyposis Colorectal Cancer DisGeNET Curated 5.164E-8 4.138E-6 3.176E-5 6.243E-5 6 117
16 C0023051 Laryngeal Diseases DisGeNET BeFree 5.476E-8 4.138E-6 3.176E-5 6.621E-5 5 58
17 C0007758 Cerebellar Ataxia DisGeNET Curated 5.866E-8 4.172E-6 3.202E-5 7.092E-5 9 453
18 C1858391 ATAXIA-TELANGIECTASIA-LIKE DISORDER DisGeNET BeFree 1.795E-7 1.206E-5 9.253E-5 2.170E-4 3 7
19 C0242787 Malignant neoplasm of male breast DisGeNET BeFree 9.725E-7 6.188E-5 4.749E-4 1.176E-3 4 43
20 C0043346 Xeroderma Pigmentosum DisGeNET Curated 1.141E-6 6.899E-5 5.295E-4 1.380E-3 5 106
21 C1303073 Nicolaides Baraitser syndrome DisGeNET Curated 1.456E-6 8.002E-5 6.142E-4 1.760E-3 3 13
22 C1096616 contralateral breast cancer DisGeNET BeFree 1.456E-6 8.002E-5 6.142E-4 1.760E-3 3 13
23 C0085390 Li-Fraumeni Syndrome DisGeNET Curated 1.799E-6 9.457E-5 7.259E-4 2.175E-3 4 50
24 C1854365 BREAST CANCER 3 DisGeNET Curated 2.841E-6 1.206E-4 9.256E-4 3.435E-3 3 16
25 C0948750 Salivary gland carcinoma DisGeNET BeFree 2.841E-6 1.206E-4 9.256E-4 3.435E-3 3 16
26 C0153467 Malignant tumor of peritoneum DisGeNET BeFree 2.841E-6 1.206E-4 9.256E-4 3.435E-3 3 16
27 C0238033 Carcinoma of Male Breast DisGeNET BeFree 3.059E-6 1.206E-4 9.256E-4 3.699E-3 4 57
28 cv:C0677776 BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer Clinical Variations 3.092E-6 1.206E-4 9.256E-4 3.739E-3 2 2
29 C2986662 Multifocal Breast Carcinoma DisGeNET BeFree 3.092E-6 1.206E-4 9.256E-4 3.739E-3 2 2
30 C0751416 Pelvic Cancer DisGeNET BeFree 3.092E-6 1.206E-4 9.256E-4 3.739E-3 2 2
31 C3274709 Contralateral Breast Carcinoma DisGeNET BeFree 3.092E-6 1.206E-4 9.256E-4 3.739E-3 2 2
32 C0940937 precancerous lesions DisGeNET BeFree 3.632E-6 1.372E-4 1.053E-3 4.391E-3 5 134
33 C2216702 malignant neoplasm of breast staging DisGeNET BeFree 4.898E-6 1.794E-4 1.377E-3 5.922E-3 3 19
34 C0025958 Microcephaly DisGeNET Curated 6.731E-6 2.326E-4 1.785E-3 8.138E-3 5 152
35 C0026470 Monoclonal Gammopathy of Undetermined Significance DisGeNET BeFree 6.950E-6 2.326E-4 1.785E-3 8.402E-3 5 153
36 C1332977 Childhood Leukemia DisGeNET BeFree 6.988E-6 2.326E-4 1.785E-3 8.449E-3 4 70
37 C0023452 Leukemia, Lymphocytic, Acute, L1 DisGeNET BeFree 7.119E-6 2.326E-4 1.785E-3 8.607E-3 7 420
38 C0281267 bilateral breast cancer DisGeNET BeFree 8.909E-6 2.667E-4 2.047E-3 1.077E-2 3 23
39 C0920506 Environment-Related Malignant Neoplasm DisGeNET BeFree 9.267E-6 2.667E-4 2.047E-3 1.120E-2 2 3
40 C2677792 Riddle Syndrome DisGeNET Curated 9.267E-6 2.667E-4 2.047E-3 1.120E-2 2 3
41 C1334411 Locally Metastatic Malignant Neoplasm DisGeNET BeFree 9.267E-6 2.667E-4 2.047E-3 1.120E-2 2 3
42 C1266082 Atypical medullary carcinoma DisGeNET BeFree 9.267E-6 2.667E-4 2.047E-3 1.120E-2 2 3
43 cv:C0346153 Familial cancer of breast Clinical Variations 1.017E-5 2.794E-4 2.145E-3 1.229E-2 3 24
44 OMIN:114480 BREAST CANCER OMIM 1.017E-5 2.794E-4 2.145E-3 1.229E-2 3 24
45 C3839280 High grade serous carcinoma DisGeNET BeFree 1.464E-5 3.934E-4 3.019E-3 1.770E-2 3 27
46 C0005859 Bloom Syndrome DisGeNET Curated 1.587E-5 4.171E-4 3.201E-3 1.918E-2 4 86
47 C0278689 Ovarian epithelial cancer recurrent DisGeNET BeFree 1.825E-5 4.304E-4 3.304E-3 2.206E-2 3 29
48 C2675080 Li-Fraumeni-Like Syndrome DisGeNET BeFree 1.851E-5 4.304E-4 3.304E-3 2.238E-2 2 4
49 C0423082 Hypometric saccades DisGeNET Curated 1.851E-5 4.304E-4 3.304E-3 2.238E-2 2 4
50 C1835817 FANCONI ANEMIA, COMPLEMENTATION GROUP N DisGeNET Curated 1.851E-5 4.304E-4 3.304E-3 2.238E-2 2 4
Show 45 more annotations