ToppGene analysis for Page/Chei Rank Ratio in cancer vs normal network




POSITIVE SIDE ANNOTATION *
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NEGATIVE SIDE ANNOTATION
RatioPageRank+ (158 genes) 5: Mouse Phenotype:abnormal bone marrow cell morphology/development
7: Pathway:Cell Cycle
11: Transcription Factor Binding Site:TMTCGCGANR UNKNOWN
13: Coexpression:Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils.
14: Coexpression Atlas:Mouse Lung E14.5 Epithelial top 500
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RatioPageRank- (158 genes) 1: GO: Molecular Function:aminoacyl-tRNA ligase activity
2: GO: Biological Process:translation
3: GO: Cellular Component:focal adhesion
7: Pathway:tRNA Aminoacylation
9: Interaction:FBXO6 interactions
10: Cytoband:22q11.21
11: Transcription Factor Binding Site:V$E2F Q6
13: Coexpression:Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h.
14: Coexpression Atlas:JC iEC top-relative-expression-ranked 2500 k-means-cluster#5
18: Disease:Shprintzen syndrome
RatioCheiRank+ (83 genes) 1: GO: Molecular Function:RNA polymerase II transcription factor activity, sequence-specific DNA binding
2: GO: Biological Process:muscle structure development
3: GO: Cellular Component:chromosomal part
5: Mouse Phenotype:abnormal leukopoiesis
7: Pathway:TGF-beta Receptor Signaling Pathway
9: Interaction:EP300 interactions
13: Coexpression:Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples.
14: Coexpression Atlas:fetal replicating Top 500 All
16: MicroRNA:TTTGTAG,MIR-520D:MSigDB
18: Disease:B-Cell Lymphomas
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RatioCheiRank- (105 genes) 1: GO: Molecular Function:transcription regulatory region DNA binding
2: GO: Biological Process:negative regulation of transcription from RNA polymerase II promoter
3: GO: Cellular Component:chromatin
5: Mouse Phenotype:abnormal bone marrow cell morphology/development
7: Pathway:Transcriptional misregulation in cancer
9: Interaction:EP300 interactions
13: Coexpression:Genes regulated by NF-kB in response to TNF [GeneID=7124].
14: Coexpression Atlas:endothelial Top 500 All
16: MicroRNA:miR-93:PicTar
18: Disease:Leukemogenesis