ToppGene analysis for Page/Chei Rank Ratio in cancer vs normal network
POSITIVE SIDE
ANNOTATION
*
*
NEGATIVE SIDE
ANNOTATION
RatioPageRank+
(
158 genes
)
5: Mouse Phenotype:
abnormal bone marrow cell morphology/development
7: Pathway:
Cell Cycle
11: Transcription Factor Binding Site:
TMTCGCGANR UNKNOWN
13: Coexpression:
Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils.
14: Coexpression Atlas:
Mouse Lung E14.5 Epithelial top 500
*
*
RatioPageRank-
(
158 genes
)
1: GO: Molecular Function:
aminoacyl-tRNA ligase activity
2: GO: Biological Process:
translation
3: GO: Cellular Component:
focal adhesion
7: Pathway:
tRNA Aminoacylation
9: Interaction:
FBXO6 interactions
10: Cytoband:
22q11.21
11: Transcription Factor Binding Site:
V$E2F Q6
13: Coexpression:
Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h.
14: Coexpression Atlas:
JC iEC top-relative-expression-ranked 2500 k-means-cluster#5
18: Disease:
Shprintzen syndrome
RatioCheiRank+
(
83 genes
)
1: GO: Molecular Function:
RNA polymerase II transcription factor activity, sequence-specific DNA binding
2: GO: Biological Process:
muscle structure development
3: GO: Cellular Component:
chromosomal part
5: Mouse Phenotype:
abnormal leukopoiesis
7: Pathway:
TGF-beta Receptor Signaling Pathway
9: Interaction:
EP300 interactions
13: Coexpression:
Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples.
14: Coexpression Atlas:
fetal replicating Top 500 All
16: MicroRNA:
TTTGTAG,MIR-520D:MSigDB
18: Disease:
B-Cell Lymphomas
*
*
RatioCheiRank-
(
105 genes
)
1: GO: Molecular Function:
transcription regulatory region DNA binding
2: GO: Biological Process:
negative regulation of transcription from RNA polymerase II promoter
3: GO: Cellular Component:
chromatin
5: Mouse Phenotype:
abnormal bone marrow cell morphology/development
7: Pathway:
Transcriptional misregulation in cancer
9: Interaction:
EP300 interactions
13: Coexpression:
Genes regulated by NF-kB in response to TNF [GeneID=7124].
14: Coexpression Atlas:
endothelial Top 500 All
16: MicroRNA:
miR-93:PicTar
18: Disease:
Leukemogenesis