| COMMUNITY ID AND NAME |
TOPPGENE ANNOTATION |
| cc100_4(Polycystin_2)+ (4 genes) |
none |
| cc101_8(DNA_methyltransferase)+ (8 genes) |
2: GO: Biological Process:peptidyl-lysine modification
9: Interaction:DNMT3A interactions
|
| cc102_6(Myogenesis)+ (6 genes) |
1: GO: Molecular Function:E-box binding
7: Pathway:CDO in myogenesis
9: Interaction:ID3 interactions
12: Gene Family:Basic helix-loop-helix proteins
13: Coexpression:Human StemCell Fukuzawa09 114genes
|
| cc103_8(Heterotrimeric_G_protein)+ (8 genes) |
1: GO: Molecular Function:G-protein beta/gamma-subunit complex binding
2: GO: Biological Process:adenylate cyclase-modulating G protein-coupled receptor signaling pathway
3: GO: Cellular Component:heterotrimeric G-protein complex
6: Domain:G alpha
7: Pathway:S1P4 pathway
9: Interaction:TSHR interactions
|
| cc105_4(Heterochromatin_protein_1)+ (4 genes) |
none |
| cc106_5(AP-1_transcription_factor)+ (5 genes) |
none |
| cc107_13(Aldosterone)+ (13 genes) |
2: GO: Biological Process:regulation of systemic arterial blood pressure by hormone
7: Pathway:Renin-angiotensin system
9: Interaction:AGT interactions
|
| cc108_15(Retromer)+ (15 genes) |
1: GO: Molecular Function:phosphatidylinositol binding
2: GO: Biological Process:endosomal transport
3: GO: Cellular Component:endosomal part
6: Domain:PX
7: Pathway:Endocytosis
12: Gene Family:Sorting nexins
|
| cc109_13(Insulin-like_growth_factor)+ (13 genes) |
1: GO: Molecular Function:insulin-like growth factor binding
6: Domain:Growth fac rcpt
7: Pathway:Genes encoding structural ECM glycoproteins
9: Interaction:IGF1 interactions
|
| cc10_9(Adapter_molecule_crk)+ (9 genes) |
7: Pathway:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
9: Interaction:CRK interactions
|
| cc110_8(C-type_lectin)+ (8 genes) |
1: GO: Molecular Function:carbohydrate binding
6: Domain:C TYPE LECTIN 1
|
| cc111_30(Adherens_junction)+ (30 genes) |
1: GO: Molecular Function:alpha-catenin binding
2: GO: Biological Process:cell-cell junction organization
3: GO: Cellular Component:cell-cell junction
6: Domain:Cadherin CS
7: Pathway:Adherens junctions interactions
9: Interaction:CTNNA3 interactions
18: Disease:Hereditary Diffuse Gastric Cancer
|
| cc112_10(KH_domain)+ (10 genes) |
6: Domain:KH 1
|
| cc113_5(Ubiquitin-activating_enzyme)+ (5 genes) |
none |
| cc114_9(Holliday_junction)+ (9 genes) |
2: GO: Biological Process:DNA recombination
7: Pathway:Resolution of D-loop Structures through Holliday Junction Intermediates
13: Coexpression:Genes involved in DNA repair, compiled manually by the authors.
|
| cc115_32(CARD_domain)+ (32 genes) |
1: GO: Molecular Function:CARD domain binding
2: GO: Biological Process:activation of innate immune response
3: GO: Cellular Component:inflammasome complex
5: Mouse Phenotype:abnormal interleukin secretion
6: Domain:-
7: Pathway:NOD-like receptor signaling pathway
9: Interaction:NLRC4 interactions
12: Gene Family:Caspase recruitment domain containing
13: Coexpression:Human Bone Lu07 301genes
|
| cc117_21(Actinin)+ (21 genes) |
1: GO: Molecular Function:structural constituent of muscle
2: GO: Biological Process:myofibril assembly
3: GO: Cellular Component:sarcomere
4: Human Phenotype:Lipoatrophy
7: Pathway:Striated Muscle Contraction
9: Interaction:TTN interactions
13: Coexpression:Human EmbryonicStemCell Xu09 622genes
14: Coexpression Atlas:geo heart top-relative-expression-ranked 500
18: Disease:LEFT VENTRICULAR NONCOMPACTION 8
|
| cc118_6(BAZ1A)+ (6 genes) |
none |
| cc119_10(Alpha_collagen)+ (10 genes) |
2: GO: Biological Process:extracellular matrix organization
3: GO: Cellular Component:extracellular matrix
13: Coexpression:Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis.
16: MicroRNA: Functional MTI
|
| cc11_16(G_protein-gated_ion_channel)+ (16 genes) |
1: GO: Molecular Function:inward rectifier potassium channel activity
2: GO: Biological Process:potassium ion import
3: GO: Cellular Component:voltage-gated potassium channel complex
6: Domain:IRK
7: Pathway:Inwardly rectifying K+ channels
12: Gene Family:Potassium voltage-gated channel subfamily J
|
| cc121_4(Vascular_endothelial_growth_factor)+ (4 genes) |
none |
| cc123_5(P21)+ (5 genes) |
3: GO: Cellular Component:Cul4-RING E3 ubiquitin ligase complex
|
| cc124_13(Amyloid_beta)+ (13 genes) |
2: GO: Biological Process:amyloid-beta metabolic process
9: Interaction:PSEN1 interactions
|
| cc125_19(MAPKKK)+ (19 genes) |
1: GO: Molecular Function:MAP kinase kinase kinase activity
2: GO: Biological Process:activation of MAPKK activity
6: Domain:PROTEIN KINASE ATP
7: Pathway:MAPKinase Signaling Pathway
9: Interaction:MAP2K7 interactions
12: Gene Family:Mitogen-activated protein kinase kinase kinases
13: Coexpression:Human Manning02 624genes ProteinKinases
|
| cc127_6(Myosin)+ (6 genes) |
3: GO: Cellular Component:actin cytoskeleton
|
| cc128_7(G_protein-coupled_receptor)+ (7 genes) |
none |
| cc129_4(Anti-neutrophil_cytoplasmic_antibody)+ (4 genes) |
none |
| cc12_21(Keratin)+ (21 genes) |
2: GO: Biological Process:intermediate filament cytoskeleton organization
3: GO: Cellular Component:intermediate filament
4: Human Phenotype:Follicular hyperkeratosis
6: Domain:IF
7: Pathway:Keratinization
9: Interaction:EPS15 interactions
10: Cytoband: 12q13.13
12: Gene Family:Keratins, type II
13: Coexpression:Human Breast Marella09 30genes
14: Coexpression Atlas:Progenitor-Cell-Biology-Consortium reference BronchioEpithel top-relative-expression-ranked 100
18: Disease:Dystrophia unguium
|
| cc130_26(C2_domain)+ (26 genes) |
1: GO: Molecular Function:calcium-dependent phospholipid binding
2: GO: Biological Process:synaptic vesicle exocytosis
3: GO: Cellular Component:presynapse
6: Domain:C2 dom
12: Gene Family:C2 domain containing|Calpains
|
| cc131_7(Dishevelled)+ (7 genes) |
7: Pathway:Wnt signaling pathway
9: Interaction:DVL1 interactions
|
| cc132_11(Kruppel-like_factors)+ (11 genes) |
12: Gene Family:Zinc fingers C2H2-type|Kruppel like factors
|
| cc133_10(Thyroid_hormones)+ (10 genes) |
5: Mouse Phenotype:abnormal thyroid-stimulating hormone level
18: Disease:Congenital Hypothyroidism
|
| cc135_32(SH2_SH3_domain)+ (32 genes) |
1: GO: Molecular Function:signaling adaptor activity
2: GO: Biological Process:actin filament organization
3: GO: Cellular Component:cell leading edge
6: Domain:SH2
7: Pathway:PDGFR-beta signaling pathway
9: Interaction:DOK1 interactions
12: Gene Family:SH2 domain containing
|
| cc136_9(Survival_of_motor_neuron)+ (9 genes) |
2: GO: Biological Process:spliceosomal snRNP assembly
3: GO: Cellular Component:Gemini of coiled bodies
7: Pathway:snRNP Assembly
9: Interaction:GEMIN8 interactions
|
| cc137_9(Glycosylphosphatidylinositol)+ (9 genes) |
none |
| cc138_8(Fibronectin_type_III_domain)+ (8 genes) |
1: GO: Molecular Function:protein tyrosine phosphatase activity
2: GO: Biological Process:peptidyl-tyrosine dephosphorylation
6: Domain:PTPc
9: Interaction:PTPRS interactions
12: Gene Family:Fibronectin type III domain containing|Protein tyrosine phosphatases, receptor type
|
| cc139_46(Cell_cycle)+ (46 genes) |
2: GO: Biological Process:G1/S transition of mitotic cell cycle
7: Pathway:Cell cycle
9: Interaction:CDK1 interactions
13: Coexpression:Human Breast Wood10 71genes CellCyle
14: Coexpression Atlas:alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3
16: MicroRNA: Functional MTI
18: Disease:Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
| cc13_187(Immune_system)+ (187 genes) |
1: GO: Molecular Function:cytokine activity
2: GO: Biological Process:leukocyte proliferation
3: GO: Cellular Component:external side of plasma membrane
4: Human Phenotype:Abnormal immunological laboratory finding
5: Mouse Phenotype:abnormal IgG level
6: Domain:IG LIKE
7: Pathway:Cytokine-cytokine receptor interaction
9: Interaction:CD9 interactions
12: Gene Family:CD molecules|Tumor necrosis factor superfamily
13: Coexpression:Human Zola07 426genes CellDifferentiationMarkers
14: Coexpression Atlas:lymph node
18: Disease:Eczema
|
| cc140_4(Very_long_chain_fatty_acid)+ (4 genes) |
none |
| cc141_11(Somatic_hypermutation)+ (11 genes) |
1: GO: Molecular Function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
2: GO: Biological Process:cytidine deamination
3: GO: Cellular Component:P-body
6: Domain:CYT DCMP DEAMINASES 1
12: Gene Family:Apolipoprotein B mRNA editing enzyme catalytic subunits
|
| cc143_18(Peroxisome)+ (18 genes) |
2: GO: Biological Process:peroxisome organization
3: GO: Cellular Component:microbody part
4: Human Phenotype:Very long chain fatty acid accumulation
7: Pathway:Peroxisome
9: Interaction:PEX19 interactions
12: Gene Family:Peroxins
13: Coexpression:Genes involve in metabolism of bile acids and salts.
18: Disease:Zellweger Syndrome
|
| cc144_28(AP-1_transcription_factor)+ (28 genes) |
1: GO: Molecular Function:DNA-binding transcription activator activity, RNA polymerase II-specific
2: GO: Biological Process:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
3: GO: Cellular Component:transcription factor complex
6: Domain:BRLZ
7: Pathway: Apoptosis signaling pathway
9: Interaction:CEBPG interactions
12: Gene Family:Basic leucine zipper proteins
13: Coexpression:Human EmbryonicStemCell Thomas08 113genes
14: Coexpression Atlas:Loop of Henle (LH)
|
| cc145_4(Monooxygenase)+ (4 genes) |
none |
| cc147_5(Synuclein)+ (5 genes) |
18: Disease:Lewy Body Disease
|
| cc148_11(Semaphorin)+ (11 genes) |
1: GO: Molecular Function:semaphorin receptor activity
2: GO: Biological Process:semaphorin-plexin signaling pathway
3: GO: Cellular Component:semaphorin receptor complex
6: Domain:Semap dom
7: Pathway:Axon guidance
12: Gene Family:Plexins
|
| cc14_4(Muscarinic_acetylcholine_receptor)+ (4 genes) |
none |
| cc150_13(Non-homologous_end_joining)+ (13 genes) |
6: Domain:BRCT
7: Pathway:Non-homologous end-joining
13: Coexpression:Genes involved in DNA replication, compiled manually by the authors.
|
| cc153_5(Diglyceride)+ (5 genes) |
none |
| cc154_14(Ubiquitin-conjugating_enzyme)+ (14 genes) |
1: GO: Molecular Function:ubiquitin conjugating enzyme activity
2: GO: Biological Process:protein polyubiquitination
3: GO: Cellular Component:ubiquitin conjugating enzyme complex
6: Domain:UQ con
7: Pathway: Ubiquitin proteasome pathway
9: Interaction:MKRN3 interactions
12: Gene Family:Ubiquitin conjugating enzymes E2
13: Coexpression:Human Liver Sakai08 86genes
|
| cc155_11(Elastase)+ (11 genes) |
6: Domain:TRYPSIN SER
|
| cc156_5(Estrone_sulfate)+ (5 genes) |
none |
| cc157_4(Cyclin-dependent_kinase_inhibitor_protein)+ (4 genes) |
none |
| cc158_4(Acid_phosphatase)+ (4 genes) |
none |
| cc15_9(Spectrin)+ (9 genes) |
1: GO: Molecular Function:structural constituent of cytoskeleton
2: GO: Biological Process:actin filament capping
3: GO: Cellular Component:spectrin
6: Domain:Spectrin
7: Pathway:Interaction between L1 and Ankyrins
9: Interaction:SPTAN1 interactions
12: Gene Family:Pleckstrin homology domain containing|Spectrins
|
| cc161_7(UTP11L)+ (7 genes) |
2: GO: Biological Process:rRNA processing
3: GO: Cellular Component:small-subunit processome
7: Pathway:rRNA modification in the nucleus and cytosol
|
| cc162_17(SMAD)+ (17 genes) |
1: GO: Molecular Function:transforming growth factor beta receptor, cytoplasmic mediator activity
2: GO: Biological Process:transmembrane receptor protein serine/threonine kinase signaling pathway
3: GO: Cellular Component:SMAD protein complex
6: Domain:SMAD dom Dwarfin-type
7: Pathway:TGF-beta signaling pathway
9: Interaction:SMAD6 interactions
12: Gene Family:SMAD family
13: Coexpression:Genes up-regulated in response to TGFB1 [GeneID=7040].
|
| cc163_6(Adenosine_deaminase)+ (6 genes) |
none |
| cc166_10(Hemoglobin)+ (10 genes) |
1: GO: Molecular Function:oxygen carrier activity
2: GO: Biological Process:oxygen transport
3: GO: Cellular Component:hemoglobin complex
6: Domain:Globin
12: Gene Family:Hemoglobin subunits
13: Coexpression:Human Leukemia Yang09 42genes
14: Coexpression Atlas:Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/mid-fetal
18: Disease:Beta thalassemia trait
|
| cc168_7(Regulator_of_G_protein_signaling)+ (7 genes) |
1: GO: Molecular Function:GTPase regulator activity
6: Domain:RGS
7: Pathway: Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
12: Gene Family:Regulators of G-protein signaling
|
| cc169_12(Pseudohypoaldosteronism)+ (12 genes) |
2: GO: Biological Process:cGMP biosynthetic process
4: Human Phenotype:Pseudohypoaldosteronism
18: Disease:Pseudohypoaldosteronism
|
| cc16_14(Lipoprotein)+ (14 genes) |
1: GO: Molecular Function:cholesterol transporter activity
2: GO: Biological Process:plasma lipoprotein particle organization
3: GO: Cellular Component:plasma lipoprotein particle
4: Human Phenotype:Xanthomatosis
5: Mouse Phenotype:abnormal circulating HDL cholesterol level
7: Pathway:lipoprotein metabolic
9: Interaction:APOA1 interactions
12: Gene Family:Apolipoproteins
13: Coexpression:Human MesenchymalStemCells Yamamoto08 83genes
18: Disease:LDL cholesterol
|
| cc170_18(Kinetochore)+ (18 genes) |
1: GO: Molecular Function:Ran GTPase binding
2: GO: Biological Process:NLS-bearing protein import into nucleus
3: GO: Cellular Component:nuclear envelope
6: Domain:ARM-like
7: Pathway:Role of Ran in mitotic spindle regulation
9: Interaction:RAN interactions
12: Gene Family:Armadillo repeat containing|Importins
|
| cc171_8(Glucocorticoid_receptor)+ (8 genes) |
1: GO: Molecular Function:transcription coactivator activity
9: Interaction:NR1I3 interactions
|
| cc172_14(Calcium_channel)+ (14 genes) |
1: GO: Molecular Function:divalent inorganic cation transmembrane transporter activity
2: GO: Biological Process:multicellular organismal signaling
3: GO: Cellular Component:calcium channel complex
7: Pathway:Cardiac conduction
9: Interaction:CACNB3 interactions
12: Gene Family:Calcium voltage-gated channel subunits
13: Coexpression:Mouse Breast VanHouten07 49genes
|
| cc173_16(Integrin)+ (16 genes) |
none |
| cc174_19(Syntaxin)+ (19 genes) |
1: GO: Molecular Function:SNAP receptor activity
2: GO: Biological Process:vesicle fusion
3: GO: Cellular Component:SNARE complex
6: Domain:t SNARE
7: Pathway:SNARE interactions in vesicular transport
9: Interaction:STX7 interactions
12: Gene Family:Syntaxins
|
| cc176_7(Core_binding_factor)+ (7 genes) |
none |
| cc178_9(T-box)+ (9 genes) |
6: Domain:TF T-box CS
12: Gene Family:T-boxes
|
| cc179_4(Knockout_mouse)+ (4 genes) |
none |
| cc17_12(Matrix_metalloproteinase)+ (12 genes) |
1: GO: Molecular Function:metalloendopeptidase activity
2: GO: Biological Process:extracellular matrix disassembly
3: GO: Cellular Component:extracellular matrix
7: Pathway:Activation of Matrix Metalloproteinases
9: Interaction:MMP14 interactions
13: Coexpression:Human Lymphoma Tome05 357genes
14: Coexpression Atlas:Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1
18: Disease:Corneal pannus
|
| cc180_4(Regulator_of_G_protein_signaling)+ (4 genes) |
none |
| cc181_12(ETS_transcription_factor_family)+ (12 genes) |
1: GO: Molecular Function:transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
6: Domain:ETS DOMAIN 1
12: Gene Family:ETS transcription factor family
|
| cc182_12(SOX_gene_family)+ (12 genes) |
2: GO: Biological Process:stem cell differentiation
6: Domain:HMG box
7: Pathway:Deactivation of the beta-catenin transactivating complex
9: Interaction:SOX5 interactions
12: Gene Family:SRY-boxes
14: Coexpression Atlas:6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s11 intermediate neurons Subtype intermediate neurons s11 Top 100 Genes
|
| cc185_40(MAPKK)+ (40 genes) |
1: GO: Molecular Function:protein serine/threonine kinase activity
2: GO: Biological Process:regulation of MAP kinase activity
6: Domain:Ser/Thr kinase AS
7: Pathway:MAPK signaling pathway
9: Interaction:MAP3K4 interactions
12: Gene Family:Mitogen-activated protein kinase kinases
13: Coexpression:Human Manning02 624genes ProteinKinases
|
| cc188_9(Gs_alpha_subunit)+ (9 genes) |
2: GO: Biological Process:receptor internalization
7: Pathway:Calcitonin-like ligand receptors
9: Interaction:CALCRL interactions
|
| cc189_14(Histone_methyltransferase)+ (14 genes) |
1: GO: Molecular Function:histone methyltransferase activity
2: GO: Biological Process:histone modification
3: GO: Cellular Component:histone methyltransferase complex
9: Interaction:KMT2A interactions
|
| cc18_8(Syndecan)+ (8 genes) |
none |
| cc190_21(Major_histocompatibility_complex)+ (21 genes) |
1: GO: Molecular Function:antigen binding
2: GO: Biological Process:antigen processing and presentation
3: GO: Cellular Component:MHC protein complex
6: Domain:MHC I/II-like Ag-recog
7: Pathway:Antigen processing and presentation
9: Interaction:B2M interactions
10: Cytoband: 6p21.3
12: Gene Family:Histocompatibility complex|C1-set domain containing
13: Coexpression:Human Immune Kong10 148genes ImmPort AntigenProcessingandPresentation
14: Coexpression Atlas:Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Tumour Wilms MNP RCC2
18: Disease:Celiac Disease
|
| cc191_5(Mitochondrial_fission)+ (5 genes) |
none |
| cc192_7(GATA_transcription_factor)+ (7 genes) |
1: GO: Molecular Function:RNA polymerase II transcription factor binding
6: Domain:ZnF GATA
12: Gene Family:GATA zinc finger domain containing
|
| cc193_4(Cofilin)+ (4 genes) |
none |
| cc194_18(Rhodopsin-like_receptors)+ (18 genes) |
none |
| cc195_11(RNA_polymerase_II)+ (11 genes) |
1: GO: Molecular Function:RNA polymerase II activity
2: GO: Biological Process:positive regulation of viral transcription
3: GO: Cellular Component:RNA polymerase II, core complex
7: Pathway:Abortive elongation of HIV-1 transcript in the absence of Tat
9: Interaction:POLR2C interactions
12: Gene Family:RNA polymerase subunits
13: Coexpression:Genes involved in DNA repair.
|
| cc198_6(Exosome_complex)+ (6 genes) |
1: GO: Molecular Function:exoribonuclease activity
2: GO: Biological Process:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
3: GO: Cellular Component:nuclear exosome (RNase complex)
6: Domain:-
7: Pathway:mRNA decay by 3' to 5' exoribonuclease
9: Interaction:DIS3L interactions
12: Gene Family:Exosome complex
|
| cc19_4(Integrin)+ (4 genes) |
none |
| cc1_4(Interleukin-5_receptor)+ (4 genes) |
none |
| cc201_6(Centrosome)+ (6 genes) |
none |
| cc202_7(DCP1A)+ (7 genes) |
none |
| cc203_12(Chloride_channel)+ (12 genes) |
1: GO: Molecular Function:chloride channel activity
2: GO: Biological Process:chloride transport
6: Domain:CBS
|
| cc207_6(Neuropeptide_Y_receptor)+ (6 genes) |
2: GO: Biological Process:neuropeptide signaling pathway
7: Pathway:Peptide ligand-binding receptors
9: Interaction:PYY interactions
|
| cc208_6(Notch_2)+ (6 genes) |
none |
| cc209_6(WW_domain)+ (6 genes) |
6: Domain:WW
|
| cc212_7(FUS)+ (7 genes) |
none |
| cc214_4(Glutamate_receptor-interacting_protein)+ (4 genes) |
none |
| cc215_13(Serine_arginine-rich_splicing_factor_1)+ (13 genes) |
9: Interaction:SRSF1 interactions
|
| cc216_18(AAA_proteins)+ (18 genes) |
1: GO: Molecular Function:ATPase activity
2: GO: Biological Process:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
3: GO: Cellular Component:proteasome regulatory particle, base subcomplex
6: Domain:AAA
7: Pathway:Synthesis of DNA
9: Interaction:CCDC74B interactions
12: Gene Family:AAA ATPases
13: Coexpression:Human Immune Kong10 148genes ImmPort AntigenProcessingandPresentation
|
| cc217_6(Signal_peptide)+ (6 genes) |
none |
| cc218_9(Fibroblast_growth_factor)+ (9 genes) |
1: GO: Molecular Function:1-phosphatidylinositol-3-kinase activity
2: GO: Biological Process:phosphatidylinositol-3-phosphate biosynthetic process
7: Pathway:Signaling by FGFR in disease
9: Interaction:FGFR2 interactions
|
| cc219_7(SR_protein)+ (7 genes) |
2: GO: Biological Process:termination of RNA polymerase II transcription
6: Domain:RRM 1
7: Pathway:mRNA 3'-end processing
9: Interaction:SREK1 interactions
12: Gene Family:RNA binding motif containing|Serine and arginine rich splicing factors
|
| cc21_34(Coagulation)+ (34 genes) |
1: GO: Molecular Function:serine-type endopeptidase activity
2: GO: Biological Process:blood coagulation
3: GO: Cellular Component:platelet alpha granule
4: Human Phenotype:Abnormality of the common coagulation pathway
5: Mouse Phenotype:abnormal blood coagulation
6: Domain:Gla
7: Pathway:Complement and coagulation cascades
9: Interaction:F2 interactions
12: Gene Family:Gla domain containing
13: Coexpression:Liver selective genes
14: Coexpression Atlas:liver
18: Disease:Thrombophilia
|
| cc221_8(RNA_polymerase_II)+ (8 genes) |
none |
| cc222_13(Interleukin)+ (13 genes) |
1: GO: Molecular Function:cytokine receptor activity
7: Pathway:Cytokine-cytokine receptor interaction
12: Gene Family:Fibronectin type III domain containing|Interleukin receptors
13: Coexpression:Human Immune Kong10 308genes ImmPort CytokineReceptors
|
| cc223_8(Janus_kinase_2)+ (8 genes) |
2: GO: Biological Process:myeloid cell differentiation
6: Domain:-
7: Pathway:Cytokine-cytokine receptor interaction
|
| cc224_9(Macrophage)+ (9 genes) |
none |
| cc225_5(Rap1)+ (5 genes) |
none |
| cc227_10(Type_I_cytokine_receptor)+ (10 genes) |
1: GO: Molecular Function:cytokine receptor activity
6: Domain:FN3
7: Pathway:Jak-STAT signaling pathway
9: Interaction:JAK1 interactions
12: Gene Family:Fibronectin type III domain containing|Interleukin receptors
13: Coexpression:Human Immune Kong10 308genes ImmPort CytokineReceptors
|
| cc228_7(Cholecystokinin_receptor)+ (7 genes) |
7: Pathway:G alpha (q) signalling events
|
| cc22_4(Corticotropin-releasing_factor_family)+ (4 genes) |
none |
| cc231_4(Neuraminidase)+ (4 genes) |
none |
| cc236_8(EVH1_domain)+ (8 genes) |
6: Domain:WH1
|
| cc239_5(Autophagosome)+ (5 genes) |
none |
| cc23_13(Base_excision_repair)+ (13 genes) |
1: GO: Molecular Function:damaged DNA binding
2: GO: Biological Process:base-excision repair
4: Human Phenotype:Endometrial carcinoma
5: Mouse Phenotype:abnormal DNA repair
7: Pathway:DNA Repair
9: Interaction:PCNA interactions
13: Coexpression:Genes involved in DNA repair, compiled manually by the authors.
18: Disease:Adenoma of large intestine
|
| cc241_7(Limb-girdle_muscular_dystrophy)+ (7 genes) |
5: Mouse Phenotype:centrally nucleated skeletal muscle fibers
18: Disease:Muscle biopsy shows dystrophic changes
|
| cc242_6(Pentraxins)+ (6 genes) |
6: Domain:PENTAXIN
|
| cc243_11(Origin_recognition_complex)+ (11 genes) |
1: GO: Molecular Function:DNA helicase activity
2: GO: Biological Process:DNA replication initiation
3: GO: Cellular Component:MCM complex
6: Domain:MCM CS
7: Pathway:Activation of ATR in response to replication stress
9: Interaction:CDC7 interactions
11: Transcription Factor Binding Site:V$E2F1 Q6
12: Gene Family:MCM family
13: Coexpression:Human Stomach Bonelli10 61genes
14: Coexpression Atlas:alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3
|
| cc244_6(Phosphatidylinositol_5-phosphate)+ (6 genes) |
none |
| cc245_13(ATPase)+ (13 genes) |
1: GO: Molecular Function:ATPase activity, coupled to transmembrane movement of substances
6: Domain:ATPase P-typ cyto domN
7: Pathway:Ion channel transport
|
| cc246_4(RAF_kinase)+ (4 genes) |
none |
| cc249_7(Pseudohypoparathyroidism)+ (7 genes) |
none |
| cc24_5(Small_Maf)+ (5 genes) |
6: Domain:bZIP Maf
9: Interaction:MAFG interactions
12: Gene Family:Basic leucine zipper proteins
|
| cc250_11(Nucleotide_excision_repair)+ (11 genes) |
1: GO: Molecular Function:RNA polymerase II CTD heptapeptide repeat kinase activity
2: GO: Biological Process:nucleotide-excision repair, preincision complex assembly
3: GO: Cellular Component:transcription factor TFIIH holo complex
4: Human Phenotype:Freckling
7: Pathway:Nucleotide excision repair
9: Interaction:GTF2H2 interactions
12: Gene Family:Lysine acetyltransferases|General transcription factors
13: Coexpression:Genes involved in DNA repair, compiled manually by the authors.
18: Disease:Trichothiodystrophy Syndromes
|
| cc251_6(Suppressor_of_cytokine_signalling)+ (6 genes) |
1: GO: Molecular Function:protein kinase inhibitor activity
2: GO: Biological Process:negative regulation of JAK-STAT cascade
6: Domain:SOCS
7: Pathway:Prolactin signaling pathway
9: Interaction:GHR interactions
12: Gene Family:SH2 domain containing|Suppressors of cytokine signaling
|
| cc252_16(Complement_system)+ (16 genes) |
1: GO: Molecular Function:complement binding
2: GO: Biological Process:complement activation
4: Human Phenotype:Hemolytic-uremic syndrome
5: Mouse Phenotype:abnormal complement pathway
6: Domain:Sushi
7: Pathway:Complement and coagulation cascades
9: Interaction:C3 interactions
12: Gene Family:Complement system|Sushi domain containing
13: Coexpression:Genes encoding components of blood coagulation system; also up-regulated in platelets.
18: Disease:Atypical Hemolytic Uremic Syndrome
|
| cc254_11(Chaperone)+ (11 genes) |
1: GO: Molecular Function:unfolded protein binding
9: Interaction:FLCN interactions
|
| cc255_5(Wnt_signaling_pathway)+ (5 genes) |
none |
| cc256_10(Kallikrein)+ (10 genes) |
12: Gene Family:Kallikreins|Proteases, serine
|
| cc259_11(Proprotein_convertase)+ (11 genes) |
1: GO: Molecular Function:serine-type peptidase activity
2: GO: Biological Process:peptide hormone processing
6: Domain:SUBTILASE ASP
7: Pathway: Alzheimer disease-amyloid secretase pathway
9: Interaction:PMCH interactions
12: Gene Family:Proprotein convertase subtilisin/kexin family
|
| cc260_9(Endoplasmic_reticulum)+ (9 genes) |
3: GO: Cellular Component:integral component of endoplasmic reticulum membrane
7: Pathway:Antigen Presentation: Folding, assembly and peptide loading of class I MHC
|
| cc261_4(RANK)+ (4 genes) |
none |
| cc262_4(Experimental_autoimmune_encephalomyelitis)+ (4 genes) |
none |
| cc263_10(S100_protein)+ (10 genes) |
1: GO: Molecular Function:RAGE receptor binding
6: Domain:S 100
7: Pathway:Genes encoding secreted soluble factors
10: Cytoband: 1q21
12: Gene Family:S100 calcium binding proteins|EF-hand domain containing
13: Coexpression:Human Immune Kong10 544genes ImmPort Antimicrobials
18: Disease:EPIDERMAL DIFFERENTIATION COMPLEX
|
| cc264_7(Amelogenesis_imperfecta)+ (7 genes) |
2: GO: Biological Process:odontogenesis
|
| cc265_6(Protein_phosphatase_1)+ (6 genes) |
1: GO: Molecular Function:phosphatase regulator activity
12: Gene Family:Protein phosphatase 1 regulatory subunits
|
| cc268_19(Aquaporin)+ (19 genes) |
1: GO: Molecular Function:water transmembrane transporter activity
2: GO: Biological Process:water transport
5: Mouse Phenotype:decreased urine osmolality
6: Domain:MIP CS
7: Pathway:Passive transport by Aquaporins
12: Gene Family:Aquaporins
|
| cc269_5(SCF_complex)+ (5 genes) |
none |
| cc270_4(Lipoxin)+ (4 genes) |
none |
| cc271_8(Tyrosine_kinase)+ (8 genes) |
none |
| cc273_4(Neurotensin_receptor)+ (4 genes) |
none |
| cc274_5(High-mobility_group)+ (5 genes) |
none |
| cc275_13(Metaphase)+ (13 genes) |
2: GO: Biological Process:sister chromatid cohesion
3: GO: Cellular Component:condensed chromosome, centromeric region
5: Mouse Phenotype:abnormal chromosome number
7: Pathway:Separation of Sister Chromatids
9: Interaction:BUB1 interactions
13: Coexpression:Human Sarcoma Chibon10 67genes genomeComplexityPredictor
14: Coexpression Atlas:Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/common lymphoid progenitor
|
| cc277_7(Protein_isoform)+ (7 genes) |
none |
| cc27_7(NADPH_oxidase)+ (7 genes) |
1: GO: Molecular Function:superoxide-generating NADPH oxidase activity
2: GO: Biological Process:superoxide anion generation
3: GO: Cellular Component:NADPH oxidase complex
6: Domain:FAD-bd 8
7: Pathway:RHO GTPases Activate NADPH Oxidases
|
| cc280_6(Protein_dimer)+ (6 genes) |
none |
| cc281_10(MST4)+ (10 genes) |
9: Interaction:STK25 interactions
12: Gene Family:STRIPAK complex
|
| cc282_16(Glutathione_peroxidase)+ (16 genes) |
1: GO: Molecular Function:antioxidant activity
2: GO: Biological Process:cellular oxidant detoxification
13: Coexpression:Genes known to modulate ROS or whose expression changes in response to ROS
|
| cc283_6(Mef2)+ (6 genes) |
none |
| cc286_4(Histone_H3)+ (4 genes) |
none |
| cc287_4(Chromosome_12_(human))+ (4 genes) |
none |
| cc288_8(Heterogeneous_ribonucleoprotein_particle)+ (8 genes) |
1: GO: Molecular Function:mRNA 3'-UTR binding
2: GO: Biological Process:mRNA splicing, via spliceosome
6: Domain:RRM 1
7: Pathway:mRNA Splicing - Major Pathway
9: Interaction:KHDRBS2 interactions
12: Gene Family:RNA binding motif containing
|
| cc289_4(Cubam)+ (4 genes) |
none |
| cc291_5(Exocyst)+ (5 genes) |
7: Pathway:VxPx cargo-targeting to cilium
9: Interaction:EXOC6B interactions
12: Gene Family:Exocyst complex
|
| cc292_4(Caveolae)+ (4 genes) |
none |
| cc295_4(Anaphylatoxin)+ (4 genes) |
none |
| cc296_4(WAVE_regulatory_complex)+ (4 genes) |
none |
| cc297_5(Angelman_syndrome)+ (5 genes) |
18: Disease:Angelman Syndrome
|
| cc299_7(Phosphatidylinositol_4_5-bisphosphate)+ (7 genes) |
2: GO: Biological Process:inositol phosphate metabolic process
7: Pathway:Inositol phosphate metabolism
|
| cc29_6(Hsp20)+ (6 genes) |
none |
| cc2_4(CCDC113)+ (4 genes) |
none |
| cc302_4(Creatine_kinase)+ (4 genes) |
none |
| cc303_4(Casein_kinase_2)+ (4 genes) |
none |
| cc306_6(VEGFR1)+ (6 genes) |
none |
| cc307_4(Chondrogenesis)+ (4 genes) |
none |
| cc308_10(TRPC)+ (10 genes) |
9: Interaction:TRPC6 interactions
|
| cc311_6(Growth_hormone)+ (6 genes) |
none |
| cc313_11(EIF2)+ (11 genes) |
1: GO: Molecular Function:translation initiation factor activity
2: GO: Biological Process:translational initiation
7: Pathway:Recycling of eIF2:GDP
9: Interaction:EIF2S1 interactions
18: Disease:Childhood Ataxia with Central Nervous System Hypomyelinization
|
| cc314_4(Arylsulfatase)+ (4 genes) |
none |
| cc317_5(Ammonia_transporter)+ (5 genes) |
1: GO: Molecular Function:ammonium transmembrane transporter activity
2: GO: Biological Process:nitrogen utilization
6: Domain:RhesusRHD
|
| cc319_4(Glycine_cleavage_system)+ (4 genes) |
none |
| cc31_32(Potassium_channel)+ (32 genes) |
1: GO: Molecular Function:potassium channel activity
2: GO: Biological Process:potassium ion transmembrane transport
3: GO: Cellular Component:voltage-gated potassium channel complex
6: Domain:VG K chnl
7: Pathway:Potassium Channels
9: Interaction:KCNA3 interactions
12: Gene Family:Potassium voltage-gated channels
13: Coexpression:Human EmbryonicStemCell Xu09 85genes
18: Disease:Long QT Syndrome
|
| cc321_6(Cilium)+ (6 genes) |
none |
| cc323_6(Iron_response_element)+ (6 genes) |
2: GO: Biological Process:iron ion homeostasis
18: Disease:Iron Overload
|
| cc324_14(SWI_SNF)+ (14 genes) |
1: GO: Molecular Function:transcription coactivator activity
2: GO: Biological Process:chromatin remodeling
3: GO: Cellular Component:SWI/SNF complex
7: Pathway:RMTs methylate histone arginines
9: Interaction:DPF3 interactions
18: Disease:Coffin-Siris syndrome
|
| cc325_5(Eukaryotic_initiation_factor_4F)+ (5 genes) |
2: GO: Biological Process:translational initiation
|
| cc329_4(Centralspindlin)+ (4 genes) |
none |
| cc32_14(Ras_subfamily)+ (14 genes) |
9: Interaction:AFDN interactions
|
| cc331_5(Ankyrin)+ (5 genes) |
none |
| cc333_4(COPII)+ (4 genes) |
none |
| cc335_17(Iron_overload)+ (16 genes) |
10: Cytoband: 1q21.1
|
| cc336_12(Fanconi_anemia)+ (12 genes) |
2: GO: Biological Process:interstrand cross-link repair
3: GO: Cellular Component:Fanconi anaemia nuclear complex
4: Human Phenotype:Pyridoxine-responsive sideroblastic anemia
5: Mouse Phenotype:induced chromosome breakage
7: Pathway:Fanconi anemia pathway
9: Interaction:FAAP20 interactions
12: Gene Family:Fanconi anemia complementation groups
13: Coexpression:Genes identified with the Fanconi anemia (FA) and the FA pathway.
18: Disease:Tracheoesophageal fistula
|
| cc33_7(Cardiotrophin_1)+ (7 genes) |
1: GO: Molecular Function:cytokine receptor binding
|
| cc341_8(BAR_domain)+ (8 genes) |
6: Domain:BAR
9: Interaction:SYNJ1 interactions
12: Gene Family:N-BAR domain containing
|
| cc344_6(Chondrocyte)+ (6 genes) |
none |
| cc346_4(Hemophagocytic_lymphohistiocytosis)+ (4 genes) |
none |
| cc34_53(Apoptosis)+ (53 genes) |
1: GO: Molecular Function:proton transmembrane transporter activity
2: GO: Biological Process:positive regulation of apoptotic signaling pathway
3: GO: Cellular Component:respiratory chain
5: Mouse Phenotype:decreased apoptosis
6: Domain:BH3
7: Pathway:intrinsic apoptotic
9: Interaction:BAX interactions
12: Gene Family:Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits
13: Coexpression:Human Lung Tahir10 14genes
16: MicroRNA: Functional MTI
|
| cc350_5(Somatostatin_receptor)+ (5 genes) |
none |
| cc351_8(Thrombospondin)+ (8 genes) |
6: Domain:TSP 1
|
| cc352_7(Alcohol_dehydrogenase)+ (7 genes) |
1: GO: Molecular Function:alcohol dehydrogenase (NAD) activity
2: GO: Biological Process:ethanol oxidation
6: Domain:ADH ZINC
7: Pathway:Ethanol oxidation
10: Cytoband: 4q23
12: Gene Family:Alcohol dehydrogenases
13: Coexpression:Human Breast Laere08 205genes
18: Disease:Pharyngeal Carcinoma
|
| cc354_6(Cell_adhesion_molecule)+ (6 genes) |
none |
| cc356_4(HCN_channel)+ (4 genes) |
none |
| cc357_5(Munc-18)+ (5 genes) |
none |
| cc358_13(AKAP)+ (13 genes) |
1: GO: Molecular Function:protein kinase A binding
2: GO: Biological Process:regulation of protein kinase A signaling
6: Domain:RII binding 1
7: Pathway:protein kinase A (PKA) signaling
9: Interaction:PRKAR2A interactions
12: Gene Family:A-kinase anchoring proteins
|
| cc35_9(Short_hairpin_RNA)+ (9 genes) |
none |
| cc361_4(TATA-binding_protein)+ (4 genes) |
none |
| cc363_16(Synapsin)+ (16 genes) |
1: GO: Molecular Function:calmodulin-dependent protein kinase activity
2: GO: Biological Process:protein autophosphorylation
3: GO: Cellular Component:postsynaptic density
6: Domain:Ca/CaM-dep Ca-dep prot Kinase
7: Pathway:Ca++/ Calmodulin-dependent Protein Kinase Activation
|
| cc365_9(Octamer_transcription_factor)+ (9 genes) |
6: Domain:POU
12: Gene Family:POU class homeoboxes and pseudogenes
|
| cc366_4(Methionine_sulfoxide)+ (4 genes) |
none |
| cc367_7(Ritonavir)+ (7 genes) |
7: Pathway:statin pharmacokinetics pathway
|
| cc36_11(Muscular_dystrophy)+ (11 genes) |
3: GO: Cellular Component:glycoprotein complex
5: Mouse Phenotype:dystrophic muscle
9: Interaction:DMD interactions
18: Disease:Becker Muscular Dystrophy
|
| cc371_5(Gap_junction)+ (5 genes) |
none |
| cc373_8(SH2_domain)+ (8 genes) |
1: GO: Molecular Function:non-membrane spanning protein tyrosine kinase activity
2: GO: Biological Process:peptidyl-tyrosine autophosphorylation
3: GO: Cellular Component:extrinsic component of cytoplasmic side of plasma membrane
6: Domain:SH2
12: Gene Family:SH2 domain containing
|
| cc376_9(Tropomyosin_receptor_kinase_)+ (9 genes) |
none |
| cc378_7(Frizzled)+ (7 genes) |
1: GO: Molecular Function:Wnt-activated receptor activity
2: GO: Biological Process:non-canonical Wnt signaling pathway
6: Domain:Frizzled/SFRP
7: Pathway:Genes related to Wnt-mediated signal transduction
12: Gene Family:G protein-coupled receptors, Class F frizzled
|
| cc379_5(Zona_pellucida-like_domain)+ (5 genes) |
none |
| cc37_9(Lysophospholipid_receptor)+ (9 genes) |
none |
| cc383_6(Phosphoinositide_3-kinase)+ (6 genes) |
none |
| cc384_4(STAT_protein)+ (4 genes) |
none |
| cc386_5(Vasoactive_intestinal_peptide_receptor)+ (5 genes) |
none |
| cc389_5(Sp_KLF_family)+ (5 genes) |
6: Domain:Sp1 fam
12: Gene Family:Zinc fingers C2H2-type|Sp transcription factors
|
| cc38_24(Serotonin)+ (24 genes) |
1: GO: Molecular Function:G protein-coupled serotonin receptor activity
2: GO: Biological Process:serotonin receptor signaling pathway
3: GO: Cellular Component:dendritic spine
5: Mouse Phenotype:abnormal behavioral response to xenobiotic
6: Domain:7TM GPCR Srsx
7: Pathway:Amine ligand-binding receptors
12: Gene Family:5-hydroxytryptamine receptors, G protein-coupled
13: Coexpression:Human EmbryonicStemCell Soh07 469genes
18: Disease:Mood Disorders
|
| cc391_4(Spermatocyte)+ (4 genes) |
none |
| cc395_4(Neural_tube_defect)+ (4 genes) |
none |
| cc39_10(Basic_helix-loop-helix)+ (10 genes) |
6: Domain:-
12: Gene Family:Basic helix-loop-helix proteins
|
| cc400_5(Thymine-DNA_glycosylase)+ (5 genes) |
none |
| cc402_4(TP53)+ (4 genes) |
none |
| cc403_7(Membrane-associated_guanylate_kinase)+ (7 genes) |
2: GO: Biological Process:establishment or maintenance of epithelial cell apical/basal polarity
6: Domain:PDZ
9: Interaction:ABCA1 interactions
12: Gene Family:Membrane associated guanylate kinases|PDZ domain containing
|
| cc406_8(Vitamin_B12)+ (8 genes) |
2: GO: Biological Process:cobalamin metabolic process
7: Pathway:Cobalamin (Cbl, vitamin B12) transport and metabolism
18: Disease:Methylmalonic aciduria
|
| cc407_7(Molybdenum_cofactor)+ (7 genes) |
none |
| cc40_6(Zinc_finger)+ (6 genes) |
none |
| cc412_4(Spliceosome)+ (4 genes) |
none |
| cc413_6(ESCRT)+ (6 genes) |
2: GO: Biological Process:multivesicular body assembly
3: GO: Cellular Component:ESCRT complex
7: Pathway:Endosomal Sorting Complex Required For Transport (ESCRT)
|
| cc415_7(Mi-2_NuRD_complex)+ (7 genes) |
1: GO: Molecular Function:histone deacetylase activity
2: GO: Biological Process:histone deacetylation
3: GO: Cellular Component:CHD-type complex
7: Pathway:RNA Polymerase I Transcription Initiation
9: Interaction:MBD3L1 interactions
12: Gene Family:Histone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex
|
| cc418_4(Pericentriolar_material)+ (4 genes) |
none |
| cc41_14(FOX_proteins)+ (14 genes) |
6: Domain:TF fork head CS 2
9: Interaction:HOXD13 interactions
12: Gene Family:Forkhead boxes
|
| cc424_4(Tropomyosin_receptor_kinase_A)+ (4 genes) |
none |
| cc428_4(Activin_type_2_receptors)+ (4 genes) |
none |
| cc429_6(Neurofilament)+ (6 genes) |
none |
| cc42_5(Dopamine)+ (5 genes) |
none |
| cc430_4(Kinetochore)+ (4 genes) |
none |
| cc433_6(Leucine_zipper)+ (6 genes) |
none |
| cc439_5(Fatty_acid-binding_protein)+ (5 genes) |
1: GO: Molecular Function:fatty acid binding
2: GO: Biological Process:triglyceride catabolic process
6: Domain:FABP
7: Pathway:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
12: Gene Family:Fatty acid binding protein family
|
| cc43_10(Chondroitin_)+ (10 genes) |
2: GO: Biological Process:dermatan sulfate biosynthetic process
3: GO: Cellular Component:lysosomal lumen
7: Pathway:Defective CHSY1 causes TPBS
9: Interaction:TNR interactions
|
| cc446_4(Bromodomain)+ (4 genes) |
none |
| cc448_6(CAF-1)+ (6 genes) |
none |
| cc44_24(Microtubule)+ (24 genes) |
1: GO: Molecular Function:microtubule binding
2: GO: Biological Process:microtubule cytoskeleton organization
3: GO: Cellular Component:microtubule
6: Domain:GCP
7: Pathway:Recruitment of mitotic centrosome proteins and complexes
9: Interaction:DCTN1 interactions
13: Coexpression:Genes important for mitotic spindle assembly.
|
| cc451_7(Charcota-Marie-Tooth_disease)+ (7 genes) |
4: Human Phenotype:Distal sensory impairment
18: Disease:Charcot-Marie-Tooth Disease
|
| cc454_4(MuSK_protein)+ (4 genes) |
none |
| cc45_7(Von_Hippela-Lindau_tumor_suppressor)+ (7 genes) |
2: GO: Biological Process:regulation of transcription from RNA polymerase II promoter in response to hypoxia
7: Pathway:Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
9: Interaction:ELOB interactions
|
| cc463_5(Neurexin)+ (5 genes) |
none |
| cc468_4(Cathepsin_L)+ (4 genes) |
none |
| cc46_16(Eukaryotic_initiation_factor)+ (16 genes) |
1: GO: Molecular Function:translation initiation factor activity
2: GO: Biological Process:formation of translation preinitiation complex
3: GO: Cellular Component:eukaryotic 43S preinitiation complex
7: Pathway:Ribosomal scanning and start codon recognition
9: Interaction:EIF3B interactions
12: Gene Family:Eukaryotic translation initiation factor 3
14: Coexpression Atlas:Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U/Ureter Normal RCC IF-U
|
| cc47_11(Bcl-2_family)+ (11 genes) |
7: Pathway:autophagy
12: Gene Family:Autophagy related
|
| cc4_7(EED)+ (7 genes) |
none |
| cc503_4(NF-kB)+ (4 genes) |
none |
| cc507_4(Cell_growth)+ (4 genes) |
none |
| cc50_4(Hedgehog_signaling_pathway)+ (4 genes) |
none |
| cc51_6(Alpha-Melanocyte-stimulating_hormone)+ (6 genes) |
none |
| cc52_9(Claudin)+ (9 genes) |
2: GO: Biological Process:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
3: GO: Cellular Component:bicellular tight junction
6: Domain:CLAUDIN
7: Pathway:Leukocyte transendothelial migration
9: Interaction:TJP1 interactions
12: Gene Family:Claudins
|
| cc53_8(Exon_junction_complex)+ (8 genes) |
2: GO: Biological Process:mRNA export from nucleus
7: Pathway:mRNA surveillance pathway
9: Interaction:RBM8A interactions
|
| cc54_13(Neurotrophic_factors)+ (13 genes) |
7: Pathway:VEGFA-VEGFR2 Pathway
|
| cc55_6(Endoplasmic_reticulum)+ (6 genes) |
none |
| cc56_13(Biogenesis_of_lysosome-related_organelles_complex_1)+ (13 genes) |
2: GO: Biological Process:pigmentation
3: GO: Cellular Component:BLOC complex
5: Mouse Phenotype:decreased platelet dense granule number
7: Pathway:Golgi Associated Vesicle Biogenesis
9: Interaction:BLOC1S3 interactions
12: Gene Family:Biogenesis of lysosomal organelles complex 1
18: Disease:Hermanski-Pudlak Syndrome
|
| cc57_7(StAR-related_transfer_domain)+ (7 genes) |
6: Domain:START
12: Gene Family:StAR related lipid transfer domain containing
|
| cc58_19(Aldehyde_dehydrogenase)+ (19 genes) |
4: Human Phenotype:Spastic paraplegia
18: Disease:Babinski Reflex
|
| cc59_9(Suprachiasmatic_nucleus)+ (9 genes) |
2: GO: Biological Process:regulation of circadian rhythm
5: Mouse Phenotype:arrhythmic circadian behavior persistence
6: Domain:PAS 3
7: Pathway: Circadian clock system
9: Interaction:PER3 interactions
|
| cc5_19(Nuclear_receptor)+ (19 genes) |
1: GO: Molecular Function:transcription factor activity, direct ligand regulated sequence-specific DNA binding
2: GO: Biological Process:transcription initiation from RNA polymerase II promoter
6: Domain:Znf hrmn rcpt
7: Pathway:Nuclear Receptor transcription pathway
9: Interaction:RXRG interactions
12: Gene Family:Nuclear hormone receptors
13: Coexpression:Human Ovarian Rae04 209genes
|
| cc60_12(Ion_channel)+ (12 genes) |
1: GO: Molecular Function:calcium channel activity
2: GO: Biological Process:calcium ion transmembrane transport
6: Domain:Ion trans dom
7: Pathway:TRP channels
9: Interaction:AKAP5 interactions
12: Gene Family:Transient receptor potential cation channels|Ankyrin repeat domain containing
|
| cc61_14(Homeobox)+ (14 genes) |
2: GO: Biological Process:regionalization
3: GO: Cellular Component:transcription factor complex
5: Mouse Phenotype:abnormal middle ear morphology
6: Domain:PAIRED 2
12: Gene Family:PRD class homeoboxes and pseudogenes|Paired boxes
|
| cc64_4(Cannabinoid_receptor)+ (4 genes) |
none |
| cc65_5(Sirtuin)+ (5 genes) |
1: GO: Molecular Function:NAD+ binding
2: GO: Biological Process:protein ADP-ribosylation
6: Domain:Sirtuin
7: Pathway:Signaling events mediated by HDAC Class I
12: Gene Family:Sirtuins
13: Coexpression:Human Leukemia Bradbury05 23genes RelatedProteinsMC
|
| cc66_6(List_of_target_antigens_in_pemphigus)+ (6 genes) |
9: Interaction:COL17A1 interactions
|
| cc67_6(FYVE_domain)+ (6 genes) |
3: GO: Cellular Component:early endosome membrane
6: Domain:FYVE
12: Gene Family:Zinc fingers FYVE-type
|
| cc68_7(Shelterin)+ (7 genes) |
2: GO: Biological Process:protein localization to chromosome, telomeric region
5: Mouse Phenotype:abnormal telomere length
7: Pathway:Regulation of Telomerase
|
| cc69_5(Glutamate_transporter)+ (5 genes) |
none |
| cc6_17(Endosome)+ (17 genes) |
2: GO: Biological Process:regulation of synaptic vesicle exocytosis
3: GO: Cellular Component:presynapse
6: Domain:RAB
7: Pathway:RAB geranylgeranylation
12: Gene Family:RAB, member RAS oncogene GTPases
|
| cc71_35(Cell_migration)+ (35 genes) |
1: GO: Molecular Function:guanyl-nucleotide exchange factor activity
2: GO: Biological Process:regulation of small GTPase mediated signal transduction
6: Domain:RHO
7: Pathway:Rho GTPase cycle
9: Interaction:RAC1 interactions
12: Gene Family:Rho family GTPases
|
| cc72_4(Endocytosis)+ (4 genes) |
none |
| cc73_10(Metastasis_suppressor)+ (10 genes) |
none |
| cc75_7(ERM_protein_family)+ (7 genes) |
3: GO: Cellular Component:filopodium
9: Interaction:EZR interactions
12: Gene Family:Minor histocompatibility antigens|FERM domain containing
|
| cc76_9(Podocyte)+ (9 genes) |
none |
| cc78_6(MCF-7)+ (6 genes) |
none |
| cc79_18(Cohesin)+ (18 genes) |
1: GO: Molecular Function:protein phosphatase regulator activity
2: GO: Biological Process:regulation of phosphoprotein phosphatase activity
3: GO: Cellular Component:protein phosphatase type 2A complex
6: Domain:B56
7: Pathway:Regulation And Function Of ChREBP in Liver
9: Interaction:PPP2R1B interactions
12: Gene Family:Protein phosphatase 2 regulatory subunits
|
| cc80_9(COP9_signalosome)+ (9 genes) |
2: GO: Biological Process:protein deneddylation
3: GO: Cellular Component:COP9 signalosome
6: Domain:PINT
7: Pathway:DNA Damage Recognition in GG-NER
9: Interaction:DCAF11 interactions
12: Gene Family:COP9 signalosome
|
| cc82_11(Pocket_protein_family)+ (11 genes) |
7: Pathway:G1 Phase
|
| cc83_13(ADP_ribosylation_factor)+ (13 genes) |
1: GO: Molecular Function:GTPase activity
2: GO: Biological Process:Golgi vesicle transport
6: Domain:ARF
7: Pathway: Huntington disease
12: Gene Family:ARF GTPase family
|
| cc86_18(TGF_beta_receptor)+ (18 genes) |
1: GO: Molecular Function:transforming growth factor beta receptor binding
2: GO: Biological Process:pathway-restricted SMAD protein phosphorylation
6: Domain:TGF-beta-rel
7: Pathway: TGF-beta signaling pathway
9: Interaction:ACVR2A interactions
12: Gene Family:Endogenous ligands
13: Coexpression:Human Immune Kong10 33genes ImmPort TGF-betaFamilyMembers
|
| cc87_4(Toll-like_receptor)+ (4 genes) |
none |
| cc88_5(Sodium_channel)+ (5 genes) |
none |
| cc89_17(Receptor_for_activated_C_kinase_1)+ (17 genes) |
9: Interaction:RACK1 interactions
|
| cc8_4(Gene_conversion)+ (4 genes) |
none |
| cc90_7(TGF_beta_receptor_2)+ (7 genes) |
9: Interaction:TGFBR2 interactions
|
| cc91_13(Androgen_receptor)+ (13 genes) |
1: GO: Molecular Function:steroid hormone receptor binding
9: Interaction:AR interactions
|
| cc93_8(ADAM)+ (8 genes) |
1: GO: Molecular Function:metalloendopeptidase activity
6: Domain:Peptidase M12B N
7: Pathway:Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
12: Gene Family:ADAM metallopeptidase domain containing
13: Coexpression:Human Breast Bergamaschi08 278genes
|
| cc94_46(RING_finger_domain)+ (46 genes) |
1: GO: Molecular Function:ribosomal S6-glutamic acid ligase activity
2: GO: Biological Process:protein autoubiquitination
3: GO: Cellular Component:ubiquitin ligase complex
6: Domain:Znf RING
7: Pathway:Antigen processing: Ubiquitination & Proteasome degradation
9: Interaction:UBE2D2 interactions
12: Gene Family:Ring finger proteins|Tripartite motif containing
|
| cc95_5(Xeroderma_pigmentosum)+ (5 genes) |
7: Pathway:Formation of Incision Complex in GG-NER
9: Interaction:SPTA1 interactions
|
| cc96_9(Leukotriene)+ (9 genes) |
2: GO: Biological Process:leukotriene metabolic process
5: Mouse Phenotype:abnormal type I hypersensitivity reaction
|
| cc97_10(Filamin)+ (10 genes) |
9: Interaction:FLNA interactions
|
| cc98_10(Interferon_regulatory_factors)+ (10 genes) |
2: GO: Biological Process:type I interferon signaling pathway
5: Mouse Phenotype:increased susceptibility to viral infection
6: Domain:IRF
7: Pathway:Interferon alpha/beta signaling
9: Interaction:IRF8 interactions
13: Coexpression:Prmary innate immune response genes induced in 293T cells (embryonic kidney) by overexpression of STING (TMEM173) [GeneID=340061].
|
| cc99_29(DNA_repair)+ (29 genes) |
1: GO: Molecular Function:damaged DNA binding
2: GO: Biological Process:double-strand break repair
3: GO: Cellular Component:chromosome, telomeric region
5: Mouse Phenotype:chromosome breakage
6: Domain:BRCT
7: Pathway:DNA Double-Strand Break Repair
9: Interaction:NBN interactions
13: Coexpression:Genes involved in DNA repair, compiled manually by the authors.
18: Disease:Fanconi Anemia
|
| cc9_51(Glycolysis)+ (51 genes) |
2: GO: Biological Process:glucose metabolic process
5: Mouse Phenotype:abnormal glycogen homeostasis
7: Pathway:Glucose metabolism
13: Coexpression:Genes specifically up-regulated in pancreatic beta cells.
18: Disease:Hyperinsulinism
|